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Summary: Epilepsy Research 44 (2001) 129140
The epileptic process as nonlinear deterministic dynamics in
a stochastic environment: an evaluation on mesial temporal
lobe epilepsy
R.G. Andrzejak a,b,
*, G. Widman a
, K. Lehnertz a
, C. Rieke a,b
, P. David b
,
C.E. Elger a
a
Department of Epileptology, Medical Center, Uni6ersity of Bonn, Sigmund Freud Str. 25, 53105 Bonn, Germany
b
Institut fu¨r Strahlen und Kernphysik, Uni6ersity of Bonn, Bonn, Germany
Received 10 October 2000; received in revised form 15 January 2001; accepted 19 January 2001
Abstract
The theory of deterministic chaos addresses simple deterministic dynamics in which nonlinearity gives rise to
complex temporal behavior. Although biological neuronal networks such as the brain are highly complicated, a
number of studies provide growing evidence that nonlinear time series analysis of brain electrical activity in patients
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