Summary: CUTTING EDGE
IMMUNOLOGY
THE
OF
JOURNAL
Cutting Edge: Dendritic Cells Copulsed with Microbial and
Helminth Antigens Undergo Modified Maturation,
Segregate the Antigens to Distinct Intracellular
Compartments, and Concurrently Induce Microbe-Specific
Th1 and Helminth-Specific Th2 Responses1
Laura Cervi,* Andrew S. MacDonald,2
* Colleen Kane,* Florence Dzierszinski,
and
Edward J. Pearce3
*
Toexaminetheabilityofdendriticcells(DC)todiscriminate
between helminth and microbial Ag and induce appropri-
ately polarized Th responses, mouse DC were copulsed
with the helminth Ag, schistosome egg Ag (SEA), along
with the bacterium Proprionebacterium acnes, Pa, and

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia
MacDonald, Andrew - Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh
Maizels, Rick - School of Biological Sciences, University of Edinburgh

Collections: Biology and Medicine; Biotechnology; Environmental Sciences and Ecology