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TheJournalofExperimentalMedicine JEM The Rockefeller University Press $8.00

Summary: TheJournalofExperimentalMedicine
JEM The Rockefeller University Press $8.00
Vol. 201, No. 1, January 3, 2005 1925 www.jem.org/cgi/doi/10.1084/jem.20041836
Toll-like receptor 9 mediates innate immune
activation by the malaria pigment hemozoin
Cevayir Coban,1,2,3 Ken J. Ishii,1,2 Taro Kawai,1,2 Hiroaki Hemmi,2
Shintaro Sato,1,2 Satoshi Uematsu,2 Masahiro Yamamoto,2
Osamu Takeuchi,1,2 Sawako Itagaki,4 Nirbhay Kumar,5
Toshihiro Horii,3,4 and Shizuo Akira1,2,3
1Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST), 2Department of Host
Defense, 3The 21st Century COE, Combined Program on Microbiology and Immunology, and 4Department of Molecular
Protozoology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
5Department of Molecular Microbiology and Immunology, Malaria Research Institute, Bloomberg School of Public Health,
Johns Hopkins University, Baltimore, MD 21205
Malaria parasites within red blood cells digest host hemoglobin into a hydrophobic heme
polymer, known as hemozoin (HZ), which is subsequently released into the blood stream and
then captured by and concentrated in the reticulo-endothelial system. Accumulating
evidence suggests that HZ is immunologically active, but the molecular mechanism(s)


Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia


Collections: Biotechnology