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Cognitive Brain Research 11 (2001) 185197 www.elsevier.com/locate/bres

Summary: Cognitive Brain Research 11 (2001) 185197
Research report
Chemical network of the living human brain
Evidence of reorganization with aging
a , b
*Igor D. Grachev , A. Vania Apkarian
Departments of Radiology, Neurosurgery and Neuroscience and Physiology, SUNY Upstate Medical University, 750 E. Adams Street, IHP 4109,
Syracuse, NY 13210, USA
Department of Physiology, Northwestern University Medical School, Chicago, IL 60611, USA
Accepted 31 October 2000
We recently described the chemical network properties of the human brain using in vivo proton magnetic resonance spectroscopy ( H
MRS). In a separate study of aging we found increased concentration of chemicals in the prefrontal and sensorimotor cortices up to the
third decade of life, and subsequent decrease of chemical concentrations in the same brain regions after the third decade between young
and middle age. We anticipated that these age-dependent differences in chemical concentrations might be a reflection of the chemical
network reorganization of the brain during aging. The pattern of chemical connectivity within and across brain regions for all regional


Source: Apkarian, A. Vania - Department of Physiology, Northwestern University


Collections: Biology and Medicine