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C. R. Mecanique 330 (2002) 557562 A mathematical model to describe the change in the

Summary: C. R. Mecanique 330 (2002) 557­562
A mathematical model to describe the change in the
constitutive character of blood due to platelet
Mohan Anand, Kumbakonam R. Rajagopal
Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843, USA
Received 15 April 2002; accepted after revision 20 June 2002
Note presented by Évariste Sanchez-Palencia.
Abstract Though a minor component by volume, platelets can have a profound influence on
the flow characteristics of blood and thereby have serious consequences with regard to
cardiovascular functions. Platelets are extremely sensitive to chemical agents as well as
mechanical inputs and platelet activation is a necessary precursor to many life threatening
medical conditions such as acute myocardial infarction, most strokes, acute arterial
occlusion, venous thrombosis and pulmonary embolism. In cardiovascular devices such
as ventricular assist devices and prosthetic heart valves, high shear stresses can trigger
platelet activation. Moreover, such devices have artificial surfaces that are thrombogenic,
the thrombotic deposition contributing to the failure of the device. Thus, there is a need
to develop a mathematical model for the flow of blood that takes into account platelet
activation, no such model being available at the moment. While there has been considerable
amount of work in blood rheology, the role of platelets in the flow characteristics of


Source: Antaki, James F. - Department of Biomedical Engineering & School of Computer Science, Carnegie Mellon University


Collections: Engineering; Biology and Medicine