Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network

  Advanced Search  

The genetics of HLA-associated disease Charles E Larsen1,2

Summary: The genetics of HLA-associated disease
Charles E Larsen1,2
and Chester A Alper1,3
Type 1 diabetes mellitus (T1D) remains the most intensively
studied, and thus the best paradigm, of MHC-associated
diseases. Accumulating evidence suggests that MHC
susceptibility for T1D is recessive, with susceptibility alleles
more common than protective alleles. Updated allele-level and
nucleotide sequence analysis of MHC class II T1D
susceptibility markers of conserved extended haplotypes
underscore the uncertainty surrounding the actual T1D MHC
susceptibility locus. Recent studies have established that
disease concordance in dizygotic twins is the same as that in
siblings generally, for both T1D and the MHC-associated
autoimmune disease gluten-sensitive enteropathy, leaving little
room for a differential environmental trigger. Epigenetic
mechanisms are probably involved in many MHC-associated
phenomena, including autoimmunity, and appear to be the best
explanation for incomplete penetrance.


Source: Alper, Chester A. - Immune Disease Institute, Harvard University


Collections: Biology and Medicine