Summary: 189
The crystal structure of rhodopsin provides significant insights
concerning structure/activity relationships in visual pigments
and related G-protein-coupled receptors. The specific
arrangement of seven-transmembrane helices is stabilized by
a series of intermolecular interactions that appear to be
conserved among Family A receptors. However, the potential
for structural and functional diversity among members of the
superfamily of seven-helical receptors presents a significant
future challenge.
Addresses
Howard Hughes Medical Institute, Laboratory of Molecular Biology and
Biochemistry, The Rockefeller University, 1230 York Avenue, New York,
NY 10021, USA; e-mail: sakmar@mail.rockefeller.edu
Current Opinion in Cell Biology 2002, 14:189­195
0955-0674/02/$ -- see front matter
© 2002 Elsevier Science Ltd. All rights reserved.
Published online 30 January 2002
DOI 10.1016/S0955-0674(02)00306-X
Abbreviation

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

Collections: Biology and Medicine