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Distinct developmental expression of Drosophila retinoblastoma factors
 

Summary: Distinct developmental expression of Drosophila
retinoblastoma factors
Scott A. Keller1
, Zakir Ullah1
, Martin S. Buckley, R. William Henry, David N. Arnosti*
Department of Biochemistry and Molecular Biology, Michigan State University, 413 Biochemistry, East Lansing, MI 48824-1319, USA
Received 22 October 2003; received in revised form 7 September 2004; accepted 8 September 2004
Available online 26 October 2004
Abstract
Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle and are implicated in a wide variety of human
tumors. Genetic analysis of RB mutations in humans and in model systems indicates that individual RB proteins also have distinct functions
in development. Specific target genes or mechanisms of action of individual RB proteins in developmental contexts are not well understood,
however. To better understand the developmental activities of the two RB family members in Drosophila, we have characterized endogenous
expression patterns of Rbf1 and Rbf2 proteins and transcripts in embryos and imaginal discs. These gene products are coexpressed at several
stages of development, however, spatial and temporal differences are evident, including partly complementary patterns of expression in the
embryonic central nervous system.
q 2004 Elsevier B.V. All rights reserved.
Keywords: Retinoblastoma; Drosophila; Rbf; Transcriptional repression
Retinoblastoma (RB) tumor suppressor proteins regulate
the cell cycle, differentiation, apoptosis, and growth by

  

Source: Arnosti, David N. - Department of Biochemistry and Molecular Biology, Michigan State University
Last, Robert L. - Department of Biochemistry and Molecular Biology, Michigan State University

 

Collections: Biology and Medicine