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vol. 173, no. 4 the american naturalist april 2009 Evolution of Acute Infections and the
 

Summary: vol. 173, no. 4 the american naturalist april 2009
Evolution of Acute Infections and the
Invasion-Persistence Trade-Off
Aaron A. King,1,2,* Sourya Shrestha,3
Eric T. Harvill,4
and Ottar N. Bjørnstad2,5
1. Departments of Ecology and Evolutionary Biology and Mathematics, University of Michigan, Ann Arbor, Michigan 48109; 2. Fogarty
International Center, National Institutes of Health, Bethesda, Maryland 20892; 3. Applied and Interdisciplinary Mathematics Program,
University of Michigan, Ann Arbor, Michigan 48109; 4. Department of Veterinary Sciences, Penn State University, University Park,
Pennsylvania 16803; 5. Departments of Entomology and Biology, Penn State University, University Park, Pennsylvania 16803
Submitted April 7, 2008; Accepted September 16, 2008; Electronically published February 20, 2009
abstract: We seek to understand the conditions favoring the evo-
lution of acute, highly transmissible infections. Most work on the
life-history evolution of pathogens has focused on the transmission-
virulence trade-off. Here we focus on a distinct trade-off that op-
erates, even among avirulent pathogens, between a pathogen's speed
of invasion and its ability to persist in a finite host population. Other
authors have shown how this invasion-persistence trade-off can lead
to intermediate pathogen attack rates but have done so only by
imposing trade-offs between the pathogen's transmissibility and the

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine