Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Rapid Publication Hypocretin (Orexin) Activation and
 

Summary: Rapid Publication
Hypocretin (Orexin) Activation and
Synaptic Innervation of the Locus
Coeruleus Noradrenergic System
TAMAS L. HORVATH,1* CHRISTELLE PEYRON,2 SABRINA DIANO,1
ALEXANDER IVANOV,3 GARY ASTON-JONES,3 THOMAS S. KILDUFF,2
AND ANTHONY N. VAN DEN POL2,4
1Department of Obstetrics and Gynecology, Yale University School of Medicine,
New Haven, Connecticut 06520
2Department of Biological Sciences, Stanford University, Stanford, California 94305
3Department of Psychiatry, University of Pennsylvania School of Medicine,
Philadelphia, Pennsylvania 19104
4Department of Neurosurgery, Yale University School of Medicine,
New Haven, Connecticut 06520
ABSTRACT
Hypocretin has been identified as a regulator of metabolic and endocrine systems. Several
brain regions involved in the central regulation of autonomic and endocrine processes or
attention are targets of extensive hypocretin projections. The most dense arborization of
hypocretin axons in the brainstem was detected in the locus coeruleus (LC). Multiple labeling
immunocytochemistry revealed a massive synaptic innervation of catecholaminergic LC cells

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collections: Biology and Medicine