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Identification of novel genes affecting mesoderm formation and morphogenesis through an enhanced large scale
 

Summary: Identification of novel genes affecting mesoderm formation
and morphogenesis through an enhanced large scale
functional screen in Xenopus
Jun-An Chena,b
, Jana Voigta,c
, Mike Gilchrista
, Nancy Papalopulua,c
, Enrique Amayaa,b,*
a
Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge CB2 1QN, UK
b
Department of Zoology, University of Cambridge, Downing Site, Cambridge, UK
c
Department of Anatomy, University of Cambridge, Downing Site, Cambridge, UK
Received 29 July 2004; received in revised form 22 October 2004; accepted 13 November 2004
Abstract
The formation of mesoderm is an important developmental process of vertebrate embryos, which can be broken down into several steps;
mesoderm induction, patterning, morphogenesis and differentiation. Although mesoderm formation in Xenopus has been intensively studied,
much remains to be learned about the molecular events responsible for each of these steps. Furthermore, the interplay between mesoderm
induction, patterning and morphogenesis remains obscure. Here, we describe an enhanced functional screen in Xenopus designed for large-

  

Source: Amaya, Enrique - Healing Foundation Centre & Developmental Biology, Faculty of Life Sciences, University of Manchester

 

Collections: Biology and Medicine