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Copyright 2009 by ASME1 INTRODUCTION

Summary: Copyright 2009 by ASME1
Transdermal drug delivery (TDD) is a promising alternative to
conventional drug delivery approaches, such as oral or injectable
routes. In comparison, the primary benefits of TDD include [1]: 1)
avoidance of first pass metabolism and other variables associated with
the GI tract such as pH changes and gastric emptying time. 2)
sustained and controlled delivery over a prolonged period of time. 3)
reduction in side effects associated with systemic toxicity. 4) improved
patient acceptance and compliance. 5) direct access to targeted or
diseased site, e.g. treatment of skin disorders. 6) ease of dose
termination in the event of any adverse reactions either systemic or
local; 7) convenient and painless administration; 8) ease of use and
reduction of overall health care treatment costs; 9) viable alternative in
circumstances where oral dosing is not possible (in unconscious or
nauseated patients).
However, human skin is a protective barrier against the loss of
excessive endogenous material such as water, and it also prevents the
access of foreign materials (chemicals and microbes). As a result, very
few drugs can be administrated transdermally due to the low


Source: Aguilar, Guillermo - Department of Mechanical Engineering, University of California at Riverside


Collections: Engineering