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Sample search results for: a-induced hepatocyte damage

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1 Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved with Wheat Protein Extract
 

Summary:  and CYP3A inducers following cryopreservation with DMSO (Rein- ach et al., 1999; Silva et al., 1999... . However, DMSO causes membrane damage and is toxic to hepatocytes, particularly at temperatures such as 25... Metabolic Activity of Cytochrome P450 Isoforms in Hepatocytes Cryopreserved ...

  

Source: Sarhan, Fathey - Département des Sciences Biologiques, Université du Québec à Montréal

 

Collection: Biology and Medicine

 
2 Abstract Hepatocyte transplantation has been proposed as an alternative to whole-organ transplantation to sup-
 

Summary:  cryopreservative damage. Moreover, the process of freezing and thawing hepatocytes has been found to be important... Abstract Hepatocyte transplantation has been proposed as an alternative to whole... , the technique of hepatocyte trans- plantation has recently moved into the clinic in order to reestablish ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
3 Hepatic Parenchymal Replacement in Mice by Transplanted Allogeneic Hepatocytes Is Facilitated by Bone Marrow
 

Summary:  with BMT- induced hepatocyte damage. Prolonged p21 Activation in BM-Transplanted Balb/C Mice. We next... Hepatic Parenchymal Replacement in Mice by Transplanted Allogeneic Hepatocytes Is Facilitated... . A desirable alternative therapeutic option is hepatocyte transplantation (HT), but this approach is ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
4 INTRODUCTION BIOARTIFICIAL LIVER (BAL) SUPPORT DEVICES can be
 

Summary:  to hepatocyte damage. The de- tails of this process are currently not known, but the area of study holds promise... many of the functions of the natural liver, and use hepatocytes, the parenchymal cells of the liver... hepatocyte functions in vitro is one current chal- lenge. This may be due in part to the ...

  

Source: Coger, Robin N. - Center for Biomedical Engineering Systems & Mechanical Engineering and Engineering Science Department, University of North Carolina at Charlotte

 

Collection: Biology and Medicine ; Engineering

 
5 Wheat Extracts as an Efficient Cryoprotective Agent for Primary
 

Summary:  ; Uchino et al., 1991). Hepatocytes are extremely sensitive to damage during freezing and thawing, even... Osm) compared to the NA WPE (602 mOsm) could further dehydrate the hepatocyte cells and increase damage due... . Viability (%) was obtained by subtracting LDH released by damaged ...

  

Source: Sarhan, Fathey - Département des Sciences Biologiques, Université du Québec à Montréal

 

Collection: Biology and Medicine

 
6 MOLECULAR AND CELLULAR BIOLOGY, May 2003, p. 30523066 Vol. 23, No. 9 0270-7306/03/$08.00 0 DOI: 10.1128/MCB.23.9.30523066.2003
 

Summary:  and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes Liang Qiao,1... )-induced signaling of extracellular signal- regulated kinases 1 and 2 (ERK1/2) in primary hepatocytes is a protective... ) pathways, and downstream transcription factors, in the survival response of hepatocytes. DCA caused

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
7 TISSUE ENGINEERING Volume 6, Number 5, 2000
 

Summary:  by Cultured Primary Porcine Hepatocytes KAMELIA BEHNIA, Ph.D.,1,3 SANGEETA BHATIA, M.D., Ph.D.,1,4 NED... . In this study, the ability of cultured primary porcine hepatocytes to detoxify xenobiotics has been exam- ined... - cated that porcine hepatocytes in vitro maintain many important liver-specific functions in- cluding

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
8 Patterned Co-Culture of Primary Hepatocytes and Fibroblasts Using
 

Summary:  Patterned Co-Culture of Primary Hepatocytes and Fibroblasts Using Polyelectrolyte Multilayer... capitalize on the preferential attach- ment and spreading of primary hepatocytes on SPS as opposed to PDAC... able to obtain patterned co-cultures of fibroblast and primary hepatocytes on synthetic PEM surfaces

  

Source: Lee, Ilsoon - Department of Chemical Engineering and Materials Science, Michigan State University

 

Collection: Materials Science

 
9 Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies
 

Summary:  of hepatocyte transplantation as a modality to replace damaged liver and as a vehicle to deliver genes for re... issues such as hepatocyte "streaming" and the origin in hepatocellular carcinoma. We now realize... that a single hepatocyte can potentially replace 90% of the liver. This unique ability supports ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
10 Wheat Proteins Improve Cryopreservation of Rat Hepatocytes
 

Summary:  ; cytochrome P450 Introduction Hepatocytes are extremely sensitive to damage incurred during freezing... GSH would result in increased susceptibility of cryopreserved hepatocytes to damage inflicted... ARTICLE Wheat Proteins Improve Cryopreservation of Rat Hepatocytes Me´lanie Grondin, ...

  

Source: Sarhan, Fathey - Département des Sciences Biologiques, Université du Québec à Montréal

 

Collection: Biology and Medicine

 
11 The Role of Proliferating Infected Hepatocytes on the Dynamics of an HBV-infected Liver
 

Summary:  . On the other hand, if infection significantly damages the proliferative potential of hepatocytes, then one can... The Role of Proliferating Infected Hepatocytes on the Dynamics of an HBV-infected Liver Sarah Hews... . Previous models assume that infected hepatocytes do not proliferate; however, the effect of ...

  

Source: Kuang, Yang - Department of Mathematics and Statistics, Arizona State University

 

Collection: Mathematics

 
12 Technical Note Engineering micropatterned surfaces for the coculture of hepatocytes and
 

Summary:  Technical Note Engineering micropatterned surfaces for the coculture of hepatocytes and Kupffer... be improved by optimizing the range of hepatocyte functions that the BAL is able to perform. One means... of achieving this is to design the BAL such that it establishes communication between hepatocytes

  

Source: Coger, Robin N. - Center for Biomedical Engineering Systems & Mechanical Engineering and Engineering Science Department, University of North Carolina at Charlotte

 

Collection: Biology and Medicine ; Engineering

 
13 Effect of cellcell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and
 

Summary:  of hepatocytes and nonparenchymal cells S. N. BHATIA, U. J. BALIS, M. L. YARMUSH, AND M. TONER1 Center... are imperative for coordinated organ function. In vitro, cocultiva- tion of hepatocytes and nonparenchymal cells... has been used to preserve and modulate the hepatocyte phenotype. We summarize previous studies

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
14 R e v i e w s MOLECULARMEDICINETODAY,MARCH1997 Liver regeneration: prospects
 

Summary:  , to reconstitute these damaged livers by transplanting intact hepatocytes from another mouse or from rats... of the damaged transgenic liver, transplanted hepatocytes need to replicate 10-12 times. These experiments have... death, hepatocytes respond to direct mitogenic agentsz. ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
15 Breast CancerResearchand Treatment21: 83-93, 1992. 1992KluwerAcademicPublishers. Printedin the Netherlands'.
 

Summary:  . Louis MO 63110, USA. Key words: bone marrow cells, gene therapy, hepatocytes, recombinant retroviruses... . The liver is the other major organ under intensive investigation. Primary hepatocytes can be isolated from... shown that human hepatocytes can also be efficiently transduced with recombinant retroviruses

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
16 Cell Transplantation, Vol. 18, pp. 7988, 2009 0963-6897/09 $90.00 + .00 Printed in the USA. All rights reserved. E-ISSN 1555-3892
 

Summary:  plants to avoid damage to the availability of hepatocytes. Future work will validate this technology... .cognizantcommunication.com Wheat Proteins Enhance Stability and Function of Adhesion Molecules in Cryopreserved Hepatocytes Me... , Universite´ du Que´bec a` Montre´al, Montre´al, Que´bec H3C 3P8, Canada Cryopreserved ...

  

Source: Sarhan, Fathey - Département des Sciences Biologiques, Université du Québec à Montréal

 

Collection: Biology and Medicine

 
17 RESEARCH Open Access Tissue inhibitor of metalloproteinase 1 (TIMP-1)
 

Summary:  -enter the cell cycle and divide by mitosis, to replace the lost or damaged hepatocytes [3]. During these wound... a dramatic exacer- bation of liver damage with widespread foci of necrotic hepatocytes. Moreover, TUNEL assay... inhibiting hepatocyte death as TIMP-1 treatment prevented ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
18 Antioxidant Functionality in Hepatocytes Using the Enhanced Collagen Extracellular Matrix
 

Summary:  Antioxidant Functionality in Hepatocytes Using the Enhanced Collagen Extracellular Matrix Under... Improvement of O2 supply in bioartificial liver devices remains a critical issue in maintaining hepatocyte... tensions during prolonged incubation times. Total glutathione concentration of cultured hepatocytes

  

Source: Coger, Robin N. - Center for Biomedical Engineering Systems & Mechanical Engineering and Engineering Science Department, University of North Carolina at Charlotte

 

Collection: Biology and Medicine ; Engineering

 
19 Donor-Derived, Liver-Specific Protein Expression after Bone Marrow Transplantation
 

Summary:  mechanism to deliver a functional gene to a deficient liver. Bone marrow-derived hepatocytes are rare... to treat liver disease is unclear. We sought to quantify bone marrow-derived hepatocyte protein expression... for human alpha-1 antitrypsin (hAAT) under a hepatocyte-specific promoter were used as bone marrow donors

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
20 MOLECULAR THERAPY Vol. 5, No. 2, February 2002 Copyright The American Society of Gene Therapy
 

Summary:  -based RV. These approaches included inducing compensatory hepatocyte replication by removing or damaging... ://www.idealibrary.com on IDEAL Transduction of Hepatocytes after Neonatal Delivery of a Moloney Murine Leukemia Virus Based... hepatocytes. As newborn animals exhibit rapid growth, we evaluated the ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine


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21 Transcription Factors ETF, E2F, and SP-1 Are Involved in Cytokine-Independent Proliferation of Murine
 

Summary:  of Murine Hepatocytes Sebastian Zellmer,1 * Wolfgang Schmidt-Heck,2 * Patricio Godoy,3 * Honglei Weng,4... investigated for many years. However, the mechanisms initiating hepatocyte ``plasticity'' and priming... 72 hours of C57BL/6N mouse hepatocyte culture on collagen monolayers (CM), which display a high basal

  

Source: Timmer, Jens - Freiburger Zentrum für Datenanalyse und Modellbildung & Physikalisches Institut, Albert-Ludwigs-Universität Freiburg

 

Collection: Physics

 
22 TOXICOLOGICAL SCIENCES 84, 110119 (2005) doi:10.1093/toxsci/kfi052
 

Summary:  December 8, 2004 In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor Jared W. Allen, Salman R... , hepatocyte subpopulations are distributed along the sinusoid in zones 1 to 3, leading to prototypical... for the investigation of hepatic physiology and patho- physiology. We have established a perfused hepatocyte bioreactor

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
23 TISSUE ENGINEERING Volume 8, Number 5, 2002
 

Summary:  morphogenesis and in vitro stabilization of the hepatocyte phenotype. The next generation of cellular therapies... can be improved further by incorporating strategies for maximizing hepatocyte function. To apply... of antigen stimulation by natural flora. Thus, complement-mediated damage of xenografts rapidly causes

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
24 Tributyltin induces apoptotic signaling in hepatocytes through pathways involving the endoplasmic reticulum and mitochondria
 

Summary:  Tributyltin induces apoptotic signaling in hepatocytes through pathways involving the endoplasmic... -n-butyltin induces pro-apoptotic signaling in rat liver hepatocytes through pathways involving the endoplasmic... hepatocytes at the nuclear level, detected by chromatin condensation and by confocal microscopy using acridine

  

Source: Sarhan, Fathey - Département des Sciences Biologiques, Université du Québec à Montréal

 

Collection: Biology and Medicine

 
25 Experimental Studies James R. Duncan, MD, PhD2
 

Summary:  . Brunt, MD Katherine P. Ponder, MD Embolization of Portal Vein Branches Induces Hepatocyte Replication... vein branches would stimulate hepatocyte replication in pigs. MATERIALS AND METHODS: The portal vein... and at computed tomography in one animal. Hepatocyte replication was determined by calculating the percentage

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
26 Nripen S. Sharma ALL RIGHTS RESERVED
 

Summary:  DIFFERENTIATION INTO HEPATOCYTES By NRIPEN S. SHARMA A Dissertation submitted to the Graduate School-New Brunswick... of Embryonic Stem Cell Differentiation into Hepatocytes By NRIPEN S. SHARMA Dissertation Director: Dr. Martin... technology to obtain hepatocyte-like cells for a number of biomedical applications. Since ...

  

Source: Rutgers University, Rutgers Center for Operations Research

 

Collection: Engineering

 
27 Gondeau C 1 To the best of their knowledge, authors have no real or perceived conflicts of interests.
 

Summary:  /RnaseL (Taguchi et al., 2004). In addition, NS5A induces the expression of IL8 which in turn negatively affects... and full length replicons, virion productive replicons, immortalised hepatocytes, fetal and adult primary... human hepatocytes. This review focuses on these different cellular models, their ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
28 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  -Associated Virus Vectors in Mouse Hepatocytes In Vivo: Cell Cycling Does Not Influence Hepatocyte Transduction... -molecular-weight concatemers in about 5% of hepatocytes. Immunohisto- chemistry and RNA in situ hybridization show... that the transgene product is made in about 5% of hepatocytes, suggesting ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
29 Basic Studies Analysis of the functional integrity of
 

Summary:  proliferate in alb-uPA/ Rag-2 or alb-uPA/NOD-SCID mice, where the alb-uPA transgene damages native hepatocytes... for cell therapy. We addressed whether human hepatocytes can recover after cryopreservation and engraft... thawing, the viability of human hepatocytes exceeded 60%. Cells attached to culture ...

  

Source: Giri, Ranjit K. - National Brain Research Centre (India)

 

Collection: Biology and Medicine

 
30 MATHEMATICAL BIOSCIENCES doi:10.3934/mbe.2009.6.283 AND ENGINEERING
 

Summary:  in HBV patients. It is well established that severe liver damage impairs hepatocyte regen- eration [31... in later stage diseases. Two aspects of hepatocyte proliferation and liver recovery from damage from HBV... pp. 283­299 THE DYNAMICS OF A DELAY MODEL OF HEPATITIS B VIRUS INFECTION WITH LOGISTIC ...

  

Source: Kuang, Yang - Department of Mathematics and Statistics, Arizona State University

 

Collection: Mathematics

 
31 Kupffer Cells Hasten Resolution of Liver Immunopathology in Mouse Models of Viral Hepatitis
 

Summary:  exclusively the hepatocyte and since liver damage during these infections is primarily a consequence... showed residual antigen reactivity in hepatocytes that appeared morphologically damaged (Figure S4... by removing apoptotic hepatocytes in a manner largely dependent on scavenger ...

  

Source: von Andrian, Ulrich H. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
32 Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4
 

Summary:  SF4 could affect TNF-a-induced apoptosis. Moreover, pTM4SF4-AS administration could pro- tect rats... Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage... treatment showed extensive liver damage and increased levels of serum ALT and AST. Decreased TM4SF4 gene

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
33 A Reverse TranscriptionPolymerase Chain Reaction Bioassay for Avian Vitellogenin mRNA
 

Summary:  , chicken embryo hepatocyte cultures are more sensitive than all other species of birds tested to the CYP1A-inducing... of vitellogenin (VTG) mRNA in avian embryo hepatocyte cultures by semiquantitative reverse transcription... concentrations of 1 nM compared with 10 nM in chicken embryo hepatocyte cultures. ...

  

Source: Moon, Thomas W. - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
34 Proc. Natl. Acad. Sci. USA Vol. 92, pp. 6210-6214, June 1995
 

Summary:  for serum urokinase concentrations, SGPT (an indicator of hepatocyte damage), and PT. Infusion of Ad... of hepatocytes in vivo (gene therapy/al antitrypsin/retroviral and adenoviral vectors) ANDRE LIEBER*, MARIE... transfer. To increase gene transfer without surgical hepatectomy, mouse hepatocytes were ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
35 Environmental Toxicology and Chemistry, Vol. 25, No. 2, pp. 496502, 2006 Printed in the USA
 

Summary:  with earlier findings that described PCB 126 as the most potent cytochrome P4501A inducer of the different PCB... FULIGINOSUS) PRIMARY HEPATOCYTES MARKUS HECKER,* MARGARET B. MURPHY, JOHN P. GIESY, and WILLIAM A. HOPKINS... -O-deethylase (EROD) in primary hepatocytes of the African brown house snake ...

  

Source: Hopkins, William A. - Department of Fisheries and Wildlife Sciences, Virginia Tech

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
36 Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for
 

Summary:  Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system... and differentiation of hepatocytes. By combining experimental data with mathematical modelling, systems biology holds... for the preparation and cultivation of primary mouse hepatocytes. To reliably monitor the dynamic induction

  

Source: Timmer, Jens - Freiburger Zentrum für Datenanalyse und Modellbildung & Physikalisches Institut, Albert-Ludwigs-Universität Freiburg

 

Collection: Physics

 
37 Zonal liver cell heterogeneity: effects of oxygen on metabolic
 

Summary:  Review Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes S. N... of hepatocytes are known to vary with position along the liver sinusoids from the portal triad to the central... of oxygen in directly or indirectly inducing differences in hepatocyte function. Partial pressure of oxygen

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
38 PI3K Inhibitors Reverse the Suppressive Actions of Insulin on CYP2E1 Expression by Activating Stress-Response Pathways
 

Summary:  Stress-Response Pathways in Primary Rat Hepatocytes JASPREET S. SIDHU, FEI LIU, SEAN M. BOYLE, and CURTIS... ) in the insulin-mediated suppression of CYP2E1 mRNA levels in hepatocytes. We investigated the dose dependence... RNA expression levels using a highly defined rat primary hepatocyte culture system. The PI3K inhibitors

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
39 Concise Review Advances in Bioartificial Liver
 

Summary:  of hepatocyte phenotype, bioreactor design, regula- tion and safety, and clinical trials. CELLULAR COMPONENT... (phase I and II pathways), and biliary excretion. The implicit assumption is that hepatocytes capable... evaluated for use in BAL. Each of these--primary hepatocytes, cell lines, and stem cells

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
40 Current Molecular Medicine 2004, 4, 753-762 753 1566-5240/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  to damage or inhibits cell death. In endotoxemia, hepatic regeneration, or TNF administration, hepatocytes... Publishers Ltd. Inflammatory Modulation of Hepatocyte Apoptosis by Nitric Oxide: In Vivo, In Vitro... NO· synthase (iNOS, NOS-2) can be either protective or damaging to the liver. We have delineated ...

  

Source: Chow, Carson C.- Laboratory of Biological Modeling, NIDDK, NIH & Department of Mathematics, University of Pittsburgh

 

Collection: Biology and Medicine ; Mathematics


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41 Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathways
 

Summary:  Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival... components could affect cell survival, we studied primary rat hepatocytes cultured on dishes coated... with collagen type 1, which was oxidized with a metal-based system. Culture of hepatocytes on oxidized collagen

  

Source: Giri, Ranjit K. - National Brain Research Centre (India)

 

Collection: Biology and Medicine

 
42 Controlling cell interactions by micropatterning in co-cultures: Hepatocytes and 3T3 fibroblasts
 

Summary:  Controlling cell interactions by micropatterning in co-cultures: Hepatocytes and 3T3 fibroblasts... Medical School, Boston, Massachusetts The repair or replacement of damaged tissues using in vitro two... or replacement of damaged tissues using Traditional co-culture systems have assessed the in- in vitro strategies

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
43 Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation
 

Summary:  Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes... hepatocytes. Methods: Primary cultured hepatocytes were prepared from SD rats. Adenoviruses and cytokines were... added 2 days and 1 h prior to the H/R insult, respectively. Hepatocytes and culture media were ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
44 Research article 1880 TheJournalofClinicalInvestigation http://www.jci.org Volume 119 Number 7 July 2009
 

Summary:  hepatocytes (10). During postnatal growth, the liver undergoes substantial changes, including gradual... polyploidization. This process gen- erates the successive appearance of tetraploid and octoploid hepatocytes with 1... (mononucleated; e.g., 4n, 8n) or 2 nuclei (binucleated; e.g., 2×2n, 2×4n). In adults, 70% of all ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
45 Contribution of Non-parenchymal Cells to the Performance of Micropatterned Hepatocytes
 

Summary:  Contribution of Non-parenchymal Cells to the Performance of Micropatterned Hepatocytes YEKATERINA S... . ZINCHENKO,1 CATHERINE R. CULBERSON,2 and ROBIN N. COGER1 ABSTRACT Hepatocytes within current bioartificial... in vivo. As recent studies suggest, the absence of controlled in- teractions between hepatocytes and non

  

Source: Coger, Robin N. - Center for Biomedical Engineering Systems & Mechanical Engineering and Engineering Science Department, University of North Carolina at Charlotte

 

Collection: Biology and Medicine ; Engineering

 
46 Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are
 

Summary:  lacking hepatocyte AHR. As one method to assess hepatocellular damage, we measured serum ALT in animals... -lox technology, we then inves- tigated the role of AHR signaling in hepatocytes or endothelial cells in mediating... venosus, whereas AHR sig- naling in hepatocytes is necessary to generate adaptive and ...

  

Source: Bradfield, Christopher A. - McArdle Laboratory for Cancer , University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
47 Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids
 

Summary:  ). To investigate whether the effect of THC on hepatocytes played a role in ConA-induced hepatitis, we cultured... . We investigated the effects of THC in a murine model of concanavalin A (ConA)-induced hepa- titis... suppression of crucial inflammatory cyto- kines in ConA-induced hepatitis. It is noteworthy ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
48 Heterotopically Transplanted Hepatocyte Survival Depends on Extracellular Matrix Components
 

Summary:  Heterotopically Transplanted Hepatocyte Survival Depends on Extracellular Matrix Components K... ABSTRACT The novel approach of tissue engineering to treat many forms of liver diseases using hepatocytes... -ECMs) to heterotopically transplanted hepatocytes allows significantly greater hepatocyte survival. We ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
49 On the role and fate of LPS-dephosphorylating activity in
 

Summary:  also tested whether exogenous intestinal AP (iAP) might protect hepatocytes from LPS-induced damage... of release from damaged hepatocytes or de novo synthesis, we studied mRNA expression in these livers using... was whether AP is able to protect the liver, and especially hepatocytes, ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
50 Cancer Res . Author manuscript Downregulation of Gadd45beta expression by hepatitis C virus leads to
 

Summary:  hepatocytes cultures to repair a UV-C damaged reporter was assayed using a host cell reactivation assay ( ,40... ). Briefly, cultures of attached primary hepatocytes were cotransfected with UV-C-damaged (15 KJ/m ) pGL2... ; Hepatitis C ; Hepatocytes ; Humans ; Liver ; Liver Neoplasms ; ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
51 Supplemental Information for "T-cadherin Modulates Hepatocyte Functions In Vitro" by Khetani et al.
 

Summary:  1 Supplemental Information for "T-cadherin Modulates Hepatocyte Functions In Vitro" by Khetani et... al. Supplemental Figure 1. Long-term induction of hepatocyte functions upon co-cultivation with T... -specific differentiation and protein synthesis) by primary rat hepatocytes was induced upon co-cultivation with CHO cells

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
52 Experiments in Transgenic Mice Show That Hepatocytes Are the Source for Postnatal Liver Growth and Do Not Stream
 

Summary:  Experiments in Transgenic Mice Show That Hepatocytes Are the Source for Postnatal Liver Growth... '2 One hypothesis is that postnatal liver growth involves replication of mature hepatocytes, which have... % of hepatocytes in two dif- ferent transgenic lines stain blue with X-gal. In neonatal animals, singlets

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
53 Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures
 

Summary:  hepatocyte cultures Katy M.O. Goyak a , Mary C. Johnson a , Stephen C. Strom b , Curtis J. Omiecinski a... online 10 May 2008 Keywords: DNA microarray Primary human hepatocytes Interindividual variability... hepatocyte cultures from ten independent donors. Correlation between basal expression in any two ...

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University; Ullmann, G. Matthias - Lehrstuhl Biopolymere, Universität Bayreuth

 

Collection: Biology and Medicine ; Chemistry

 
54 In Vivo Correction of Murine Tyrosinemia Type I by DNA-Mediated Transposition
 

Summary:  correction of the metabolic liver disease and sec- ondary renal damage. Transposon-modified hepatocytes could... corrected FAH hepatocytes are clonally selected and stable integration events can therefore be quantified... and characterized at the molecular level. Herein, we demonstrate that SB-transposon- transfected ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
55 JOURNAL OF VIROLOGY, Jan. 2005, p. 214224 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.214224.2005
 

Summary:  .1.214­224.2005 Copyright © 2005, American Society for Microbiology. All Rights Reserved. Unrestricted Hepatocyte... portion of hepatocytes even after administration of extremely high vector doses. In order to investigate... vector dose-response remained unchanged at any dose and ultimately could transduce all the hepatocytes

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
56 Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip
 

Summary:  in radiation damage to hepatocytes after 2 Gy of radiation (3% damaged cells). 4. Discussion The closed... (hepatocytes) expressed less radiation damage due to drug treatment, when compared to the no drug control... to the target cell type and (2) hepatocytes as the ...

  

Source: Sun, Wei - Department of Mechanical Engineering and Mechanics, Drexel University

 

Collection: Engineering

 
57 In Vitro Liver Tissue Model Established from Transgenic Mice: Role of HIF-1alpha on Hypoxic Gene Expression
 

Summary:  ,2,4,5 ABSTRACT The instability of the hepatocyte phenotype in vitro has limited the ability to quantitatively... stable liver tissue in vitro by forming collagen ``sandwich'' cultures of transgenic murine hepatocytes... -type and HIF- 1a null hepatocyte cultures. We identified more than 130 genes differentially expressed under

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
58 10.1101/gad.1453606Access the most recent version at doi: 2006 20: 2648-2653Genes & Dev.
 

Summary:  This report demonstrates that quiescent hepatocytes are resistant to the DNA damage signal elicited by dysfunc... . Yet, hepatocytes survive this damage, sug- gesting that the effector pathway of the telomere DNA... ;Supplemental Data Supplemental Figure 1. Transient DNA damage response in ...

  

Source: de Lange, Titia - Laboratory for Cell Biology and Genetics, Rockefeller University

 

Collection: Biology and Medicine

 
59 CELL PRESERVATION TECHNOLOGY Volume 2, Number 4, 2004
 

Summary:  . Unfortunately, the process itself can damage the cells such that the number of vi- able cells after thawing... hepatocytes. In the current study, directional solidification is used to help improve success when cooling... hepatocytes to subzero temperatures. Specifically, by analyzing the crystallization of solutions, cell

  

Source: Coger, Robin N. - Center for Biomedical Engineering Systems & Mechanical Engineering and Engineering Science Department, University of North Carolina at Charlotte

 

Collection: Biology and Medicine ; Engineering

 
60 ANALYSIS OF HEPATITIS C VIRUS INFECTION MODELS WITH HEPATOCYTE HOMEOSTASIS
 

Summary:  ANALYSIS OF HEPATITIS C VIRUS INFECTION MODELS WITH HEPATOCYTE HOMEOSTASIS TIMOTHY C. RELUGA... virus (HCV) infection that explicitly includes proliferation of infected and uninfected hepatocytes... of the target cell population. Since it has been suggested that hepatocytes, the major cell type in the liver

  

Source: Reluga, Tim - Department of Mathematics, Pennsylvania State University

 

Collection: Mathematics


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61 H U M A N G E N E T H E R A P Y 7:2113-2121 (November 10, 1996) Mary Ann Liebert, Inc.
 

Summary:  procedures to achieve ex vivo or in vivo transduction of hepatocytes. In vivo delivery involves injection... for the liver, induction of hepatocyte replication requires a 7 0 % partial hepatectomy or administra- tion... of a liver toxin. A n altemative method for inducing hepatocyte replication is to occlude branches

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
62 RESEARCH ARTICLE Open Access HNF1a inhibition triggers epithelial-mesenchymal
 

Summary:  Bioulac-Sage4,5 and Jessica Zucman-Rossi1,2,6* Abstract Background: Hepatocyte Nuclear Factor 1a (HNF1a... changes in gene expression using qRT-PCR and Western Blot. Results: Hepatocytes transfected with HNF1a si... . In HNF1a-inhibited cells, hepatocyte and epithelial markers were diminished and mesenchymal markers were

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
63 ALL RIGHTS RESERVED DESIGN AND ANALYSIS OF AMINO ACID SUPPLEMENTATION
 

Summary:  IN HEPATOCYTE CULTURE USING IN VITRO EXPERIMENT AND MATHEMATICAL MODELING By HONG YANG A Dissertation submitted... of Amino Acid Supplementation in Hepatocyte Culture Using in vitro Experiment and Mathematical Modeling... .D. Extracorporeal bioartificial liver (BAL) devices, involving primary hepatocytes, represent a promising ...

  

Source: Rutgers University, Rutgers Center for Operations Research

 

Collection: Engineering

 
64 Probing the Cytotoxicity of Semiconductor Quantum Dots
 

Summary:  hepatocytes as a liver model, we found that CdSe-core QDs were indeed acutely toxic under certain conditions... M) are known to reduce the viability of hepatocytes in vitro.17 Furthermore, more than 25% of the cadmium... of hepatocytes, detoxifies cadmium by se- questering it into an inert complex. Yet, the small amounts

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
65 Lipopolysaccharide Potentiates the Effect of Hepatocyte Growth Factor upon Replication
 

Summary:  Lipopolysaccharide Potentiates the Effect of Hepatocyte Growth Factor upon Replication in Lung... in vivo gene therapy, as some viral vectors only transduce dividing cells. Hepatocyte growth factor (HGF... ) increases the percentage of replicating hepatocytes to 18-fold that in normal rats, and lipopolysaccharide

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
66 letters to nature NATURE |VOL 406 |27 JULY 2000 |www.nature.com 435
 

Summary:  , dictates the species-specific pattern of CYP3A inducibility. Thus, we can generate `humanized' transgenic... Ageneisnolongerinducedinresponsetotheprototypicrodent- specific CYP3A inducers, pregnenolone-16 -carbonitrile (PCN; Fig. 1d; ref. 11) and dexamethasone... /PXR and their response elements are essential ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
67 Novel Quantitative Tools for Engineering Analysis of Hepatocyte Cultures in
 

Summary:  Novel Quantitative Tools for Engineering Analysis of Hepatocyte Cultures in Bioartificial Liver... the device is exposed to plasma from the patient, hepatocytes are prone to accumulate intracellular lipids... mathematical programming techniques to optimize the biochemical environment of hepatocyte cultures towards

  

Source: Rutgers University, Rutgers Center for Operations Research

 

Collection: Engineering

 
68 cMet Activation Allows Persistent Engraftment of Ectopically Transplanted Xenogenic Human Hepatocytes in Mice
 

Summary:  Hepatocytes in Mice K. Ohashi, L. Meuse, R. Schwall, and M.A. Kay HEPATOCYTE TRANSPLANTATION (HT) is con... - neous space) of hepatocytes has a decreased potential for complications observed with intraportal... of the human hepatocytes transplanted into two different ectopic sites in immunode- ficient mice. ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
69 J. Hemato. Ther. Hepatic oval (stem) cell expression of EDG receptors for
 

Summary:  of hepatocyte progenitors in regenerating liver. inserm-00110153,version1-7Nov2006 #12;3 Introduction... injury and human pathologic ductular reactions (1-4). Small hepatocyte-like oval cells originated from... rat hepatocytes (20). Our recent studies revealed the presence of LPA1 and LPA2 receptors

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
70 Multiple Adaptive Mechanisms to Chronic Liver Disease Revealed at Early Stages of Liver Carcinogenesis
 

Summary:  , Ribeiro FP, Souza GM, Campa A. Serum amyloid A-induced mRNA expression and release of tumor necrosis... of liver tissue. Despite stimulation of hepatocyte DNA replication, their mitotic activity was blocked... overexpressed. Increased mitotic activity of hepatocytes resulted in multiple dysplastic nodules, some of them

  

Source: Domany, Eytan - Physics of Complex Systems, Weizmann Institute of Science

 

Collection: Biology and Medicine ; Physics

 
71 Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes.
 

Summary:  ., 2001. Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes... hepatocytes. Laville N.a,b , Aït-Aïssa S.a , , Gomez, E.b and Casellas C.b , Porcher J.M.a a Unité d... Trout Hepatocytes; Cytotoxicity; EROD; Oxidative Stress. #12;3 Abstract Pharmaceuticals are ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
72 Efficient Gene Transduction to Cultured Hepatocytes by HIV-1 Derived Lentiviral Vector
 

Summary:  Efficient Gene Transduction to Cultured Hepatocytes by HIV-1 Derived Lentiviral Vector K. Ohashi, F... . Park, R.H. Schwall, and M.A. Kay HEPATOCYTE transplantation can be considered a viable and effective... of liver failure.1 However, genetic modifica- tions of hepatocytes in an ex vivo manner may further advance

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
73 Gene Therapy (1997) 4, 351360 1997 Stockton Press All rights reserved 0969-7128/97 $12.00
 

Summary:  infected with Ad.RSV-gp19K produced a native of surface MHC I molecules on hepatocytes, and surface size gp... infection compared metry. The congenic mouse strains Balb/b (H-2b MHC I with hepatocytes transduced... -stimulatory signals required for T significant amounts of any E3 proteins in hepatocytes in cell activation

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
74 Oxidoreductase HepG2 Huh7 Hepatocytes
 

Summary:  Oxidoreductase HepG2 Huh7 Hepatocytes 0 25 50 75 100 Not changed Increased Decreased * * p<0... .001 Percent Transferase HepG2 Huh7 Hepatocytes 0 25 50 75 100 * Percent Detoxification HepG2 Huh7 Hepatocytes... hepatocyte cultures, established hepatoma cell lines and liver tissues K.M. Olsavsky1, J.L. Page1, ...

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
75 JOURNAL OF VIROLOGY, 0022-538X/97/$04.00 0
 

Summary:  with liver damage, apoptosis, and hepatocellular DNA synthesis. While Kupffer cell depletion nearly... to a direct effect of the virus particle on the hepatocyte. Early liver toxicity as determined by serum... effect on adenovirus-mediated hepatocyte apop- tosis but did increase hepatocellular DNA synthesis

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
76 General discussion and perspectives Marcella Martignoni1, Ruben de Kanter2 and Geny Groothuis3
 

Summary:  human/rodent specific CYP3A inducers during the early phase of drug development [13]. However... be due to the increased substrate availability in the damaged slices. In fact, the viability parameters... measured, demonstrated that some degree of tissue damage was apparent in cryopreserved liver slices

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
77 ICANCERRESEARCH55. 5242-5250, November 15, 19951 The cell ofongin of hepatocellularcarcinoma (HCC) is controversial. A
 

Summary:  ras and p3-gal genes (Ras-gal) was transferred into adult rat hepatocytes in vivo, and some animals... transduction, suggesting that hepatocytes can develop into HCC or CC if sufficient genetic alterations occur... remains controversial (20â"22).Some investigators believe that the hepatocyte can develop into HCC

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
78 Target Gene Therapy for -Fetoprotein-Producing Hepatocellular Carcinoma by
 

Summary:  damage since the virus maintains the capacity to replicate in normal hepatocytes. Al- though Adv-E1Ad... -deficient adenovirus was able to rep- licate in human primary hepatocytes, we therefore designed an adenovirus carrying... the replication specific- ity in AFP-producing HCC. Replication of Adv-AFP- E1AdB in primary ...

  

Source: Marignani, Paola - Department of Biochemistry and Molecular Biology, Dalhousie University

 

Collection: Biology and Medicine

 
79 Subcellular Site of Superoxide Dismutase Expression Differentially Controls AP-1 Activity and Injury in Mouse Liver Following
 

Summary:  AMIE LANG,1 RALF M. ZWACKA,4 AND JOHN F. ENGELHARDT1-3 Acute damage following ischemia and reperfusion... - atocellular damage. In the present study, we have compared the therapeutic effects of ectopic expression... vectors for reduc- ing I/R damage in the liver. Consistent with previous obser- vations, recombinant

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
80 Bradfield; Mechanisms of Liver Carcinogenesis 1 Chris Bradfield, 262-2024
 

Summary:  or significant liver damage, why? Ploidy: Hepatocytes are unusual in that their ploidy can be quite high... . Liver Cell types. Hepatocytes (70-90% of liver mass, depending on the species) metabolize and excrete... into sinusoids or bile canaliculi. Many hepatocytes are not terminally differentiated and can ...

  

Source: Bradfield, Christopher A. - McArdle Laboratory for Cancer , University of Wisconsin at Madison

 

Collection: Biology and Medicine


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81 Dying for NF-jB? Control of cell death by transcriptional regulation of the apoptotic machinery
 

Summary:  : An essential role for NF-jB in preventing TNF-a-induced cell death. Science 1996, 274:782-784. 22. Li ZW, Chu W... : Suppression of TNF-a-induced apoptosis by NF-jB. Science 1996, 274:787-789. 26. Hatano E, Bennett BL, Manning... cells from tumor necrosis factor a- induced apoptosis. J Exp Med 1998, ...

  

Source: Burstein, Ezra - Cellular and Molecular Biology Program, University of Michigan

 

Collection: Biology and Medicine

 
82 JOURNAL OF VIROLOGY, Dec. 1996, p. 87828791 Vol. 70, No. 12 0022-538X/96/$04.00 0
 

Summary:  , American Society for Microbiology Elimination of Hepatitis C Virus RNA in Infected Human Hepatocytes... primary human hepatocytes obtained from chronic HCV-infected patients. This study demonstrates... reduced or eliminated HCV RNA from an experimental cell line and from human hepatocytes isolated from two

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
83 Downregulation of Gadd45 Beta Expression by Hepatitis C1 Virus Leads to Defective Cell Cycle Arrest2
 

Summary:  host cell reactivation assays237 The ability of primary hepatocytes cultures to repair a UV-C damaged... primary hepatocytes were cotransfected with UV-C-damaged (15 KJ/m²)240 pGL2, together with pGFP to control... and increased G2/M346 progression in the presence of DNA damage. To this ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
84 Comparative Biochemistry and Physiology Part C 137 (2004) 8193 1532-0456/04/$ -see front matter 2003 Elsevier Inc. All rights reserved.
 

Summary:  concentration for EROD induction and 0.052 nM as the EC50. PCB 126 is a potent CYP1A inducer in ovo as reported... in chick embryo hepatocytes. Embryos were injected into the air cell with 1.6 mg 3... implicate oxidative damage as a contributor to the general toxicity syndrome of many HAHs including

  

Source: Moon, Thomas W. - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
85 Molecular mechanisms of the chemopreventive effect on hepatocellular carcinoma development in
 

Summary:  that tannic acid protects mice from the tumor necrosis factor-a­induced lethal hepatitis (39). It is also... in bile regurgitation (9) and portal inflammation followed by the development of hepatocyte dysplasia... hepatocytes (17) and attenuates plasminogen activator activity in the liver of C3H hepatocellular carcinoma

  

Source: Domany, Eytan - Physics of Complex Systems, Weizmann Institute of Science

 

Collection: Biology and Medicine ; Physics

 
86 Stern, C.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In: Hepatocyte Growth Factor -Scatter Factor (HGF-SF) and the c-MET receptor. (ed. I.D. Goldberg and E. Rosen) Basel: Birkhauser Verlag. pp. 369-380.
 

Summary:  : Hepatocyte Growth Factor - Scatter Factor (HGF- SF) and the c-MET receptor. (ed. I.D. Goldberg and E. Rosen... inducing molecule in vertebrate embryos? In: Hepatocyte Growth Factor - Scatter Factor (HGF- SF) and the c... .D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In: Hepatocyte Growth

  

Source: Stern, Claudio - Department of Cell and Developmental Biology, University College London

 

Collection: Biology and Medicine

 
87 ABSTRACT RESULTS INTRODUCTION
 

Summary:  the use of lentivectors for the genetic manipulation of primary human hepatocytes in non-dividing cultures... . Infection of hepatocytes with green fluorescence protein (GFP)-expressing lentivectors (MOI=5) resulted... of assessed hepatocyte expression markers, including the phenobarbital (PB) induction response ­ a hallmark

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
88 Proc. Nail. Acad. Sci. USA Vol. 89, pp. 89-93, January 1992
 

Summary:  -antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes (gene therapy... /canine hepatocyte/autologous tnsplantation/cytomegalovirus promoter) MARK A. KAY*t, PATRICIA BALEY*, STEVEN... the deficiency of liver-specific gene products. We have previously demonstrated that transgenic mouse ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
89 ACCELERATED COMMUNICATION Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like
 

Summary:  effects, namely hepatocyte damage and infiltration of inflammatory cells. Using a triple-null mouse model... damage. In addition, the triple-null mice were protected from dioxin-in- duced liver inflammation. Loss... of toxic effects, includ- ing hepatocellular damage, thymic involution, teratogenesis, and ...

  

Source: Bradfield, Christopher A. - McArdle Laboratory for Cancer , University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
90 The FASEB Journal Research Communication T-cadherin modulates hepatocyte functions in vitro
 

Summary:  The FASEB Journal · Research Communication T-cadherin modulates hepatocyte functions in vitro... of Medicine, Brigham & Women's Hospital, Boston, Massachusetts, USA ABSTRACT Primary hepatocytes from several... functions in primary hepatocytes in vitro; however, the molecular mediators underlying this "coculture

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
91 Microfabrication of Hepatocyte/Fibroblast Co-cultures: Role of Homotypic Cell Interactions
 

Summary:  Microfabrication of Hepatocyte/Fibroblast Co-cultures: Role of Homotypic Cell Interactions S. N... " co-cultures of primary rat hepatocytes and murine 3T3-J2 fibroblasts to investigate the role... the isolation of fibroblast number as an independent variable in hepatic function. Notably, homotypic hepatocyte

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
92 Diverse Roles of Invariant Natural Killer T Cells in Liver Injury and Fibrosis Induced by Carbon Tetrachloride
 

Summary:  J 18 / mice are resistant to concanavalin A-induced and -GalCer­induced acute liver injury... by HSC-presenting lipid antigens released from damaged hepatocytes after CCl4 Fig. 6. Chronic CCl4... necrosis/apoptosis. Damaged hepatocytes release lipid antigens, which can be presented by ...

  

Source: Lian, Zhe-Xiong - School of Life Sciences, University of Science and Technology of China

 

Collection: Biology and Medicine

 
93 Expansion of Donor Hepatocytes After Recombinant Adenovirus-Induced Liver Regeneration in Mice
 

Summary:  Expansion of Donor Hepatocytes After Recombinant Adenovirus-Induced Liver Regeneration in Mice... . KAY 1,3 ally active hepatocytes migrating to the liver, where they areHepatocyte transplantation... tagged donor mouse hepatocytes, it has been deter-tion in hepatocytes causes the slow ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
94 SCOPE OF THE THESIS Liver fibrosis is characterized by the accumulation of excessive amounts of
 

Summary:  of scar tissue in the injured liver serves as a repair mechanism to allow proper healing of the damaged... tissue is disproportionate to the extent of tissue damage. In its advanced stages the disease... other cell types. Inhibition of hepatocyte proliferation, for example, may result in an impaired

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
95 Somatic Cell and Molecular Genetics, Vol. 18, No. 1, 1992, pp. 89-96 Reconstitution of Enzymatic Activity in Hepatocytes of
 

Summary:  Activity in Hepatocytes of Phenylalanine Hydroxylase-Deficient Mice Ta-Jen Liu, t'2Mark A. Kay,2'3Gretchen... control of the human CMV promoter was constructed and used to transduce hepatocytes isolated from IMH... -deficient mice. Viral-transduced hepatocytes produced dramatically higher levels of mouse PAH mRNA as compared

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
96 Oxygen Is a Factor Determining In Vitro Tissue Assembly: Effects on Attachment
 

Summary:  of Hepatocytes Avi Rotem, Mehmet Toner, Sangeeta Bhatia, Brent D. Foy, and Ronald G. Tompkins, and Surgical... Many recent studies related to the development of bioartificial liver devices have utilized hepatocytes... cultured within devices of various geometries. Because hepatocytes are anchorage-dependent cells, they need

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
97 Gliotoxin non-selectively induces apoptosis in fibrotic and normal livers
 

Summary:  . During liver fibrosis, the hepatic stellate cell (HSC) plays a crucial role. After hepatocyte damage... endothelial cells were also affected by GTX, whereas hepatocytes were only mildly affected. This study... in vitro. In addition, it reduces hepatic fibrosis through HSC apoptosis while leaving the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
98 ForPeerReview Hepatologyinserm-00519450,version1-20Sep2010 Author manuscript, published in "Hepatology (Baltimore, Md.) 2010;52(3):1046-59"
 

Summary:  and remained undetectable in hepatocytes. Administration of CCl4 to CB2-/- mice accelerated liver injury... , as shown by increased ALT/AST levels and hepatocyte apoptosis, and delayed liver regeneration, as reflected... by a retarded induction of hepatocyte PCNA expression; PCNA induction was also delayed in CB2-/- mice ...

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
99 TISSUE ENGINEERING Volume 10, Number 7/8, 2004
 

Summary:  hepatocyte-based devices and im- plantable hepatocyte­scaffold tissue-engineered constructs, maintenance... , liver-derived biomatrix (LBM) as a bioresorbable scaffold for primary hepatocytes. Primary rat... hepatocytes were cultured on LBM and compared with well-characterized hepatocyte ...

  

Source: Bhatia, Sangeeta - Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
100 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  of hepatic phenotype in lentiviral-transduced primary human hepatocytes Stephanie M. Zamulea , Stephen C... hepatocytes Lentivirus Differentiation CAR siRNA a b s t r a c t Lentiviral vectors effectively transduce both... evaluated the usefulness of a lentiviral system for genetic modulation of primary human hepatocyte cultures

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University; Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine


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