| Sample search results for: a32 modular polyketide |
| 1 | CHAITAN KHOSLA Wells H. Rauser and Harold M. Petiprin Professor | ||
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Summary: of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)., J. Bacteriol., 177... .E. and Khosla, C., Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase... ring size by directed mutagenesis of a ... |
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Source: Stack, T. Daniel P. - Department of Chemistry, Stanford University |
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Collection: Chemistry |
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| 2 | Structure and mechanism of chalcone synthase-like polyketide , J-L Ferrer2 | ||
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Summary: Structure and mechanism of chalcone synthase-like polyketide synthases JM Jez1 , J-L Ferrer2 , ME... Biology Division, Samuel Roberts Noble Foundation, P.O. Box 2180, Ardmore, OK 73402, USA Polyketide... and pharmacological properties by varying the starter and extender molecules that form the final polyketide. Recent |
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Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 3 | Structural control of polyketide formation in plant-specic polyketide synthases | ||
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Summary: is released. Elongation of the polyketide occurs through either a modular or an iterative approach [7... factor common to both modular and aromatic polyketide synthases. Na- ture 401, 502^505. 35. Carreras, C... Structural control of polyketide formation in plant-speci¢c ... |
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Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 4 | Structure 14, 737748, April 2006 2006 Elsevier Ltd All rights reserved DOI 10.1016/j.str.2006.01.009 The Structure of a Ketoreductase Determines | ||
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Summary: polyketide synthase acyl carrier protein from Strep- tomyces coelicolor A3(2). Biochemistry 36, 6000... . While some successes in engineering modular PKSs to produce novel polyketides have been reported... , C. (1996). A functional chimeric modular ... |
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Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine |
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| 5 | C H A P T E R E I G H T Type I Polyketide Synthases That | ||
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Summary: Figure 8.1 Modular organization of type I polyketide synthases (PKSs). (A) A proto- typical type I PKS... modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula... ., and Khosla, C. (2003). Quantitative analysis of loading and extender acyltransferases of ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 6 | Polyketide Chain Skipping Mechanism in the Biosynthesis of the Hybrid Nonribosomal Peptide-Polyketide Antitumor Antibiotic Leinamycin in Streptomyces atrooliWaceus S-140 | ||
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Summary: Ved NoVember 11, 2005 A fundamental feature of modular polyketide synthases (PKSs) is the highly... -methylation process. These findings provide new insights into the polyketide chain skipping mechanism for modular PKSs... in the resultant polyketide products.1,2 The collinearity between ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 7 | Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin | ||
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Summary: for review July 30, 2001) As the first structural elucidation of a modular polyketide synthase (PKS) domain... suggests that all TEs from modular polyketide synthases have a similar fold, dimer 2-fold axis... , and substrate channel geometry. Modular polyketide ... |
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Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine |
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| 8 | O O O O O O O Several products | ||
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Summary: Me O O O O O O O OH a Several products Polyketide chain b HO OH O OH OH O Noranthrone (only product... modular PKSs. The authors also observe a clear binding region for the phosphopantetheine arm of Pks... A that guides polyketide substrates into the PT domain's binding pocket (Fig. 1b). Fur- thermore, by obtaining |
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Source: Hell, Stefan W. - Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry; Heller, Eric - Departments of Chemistry & Physics, Harvard University |
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Collection: Chemistry ; Materials Science ; Physics |
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| 9 | Protist, Vol. 159, 21--30, January 2008 http://www.elsevier.de/protis | ||
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Summary: October 2007 ORIGINAL PAPER Novel Insights into Evolution of Protistan Polyketide Synthases through... Submitted November 27, 2006; Accepted July 31, 2007 Monitoring Editor: Herve´ Philippe Polyketide synthase... acid synthases involved in lipid metabolism. Polyketide biosynthesis of secondary metabolites and hence |
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Source: Gent, Universiteit - Department of Plant Systems Biology, Bioinformatics and Evolutionary Genomics Division |
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Collection: Biology and Medicine |
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| 10 | Summary and general conclusions Chapter six | ||
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Summary: is performed by large multienzyme complexes, designated peptide synthetases, which exhibit a modular structure... - or polyketide synthases. These hybrid synthetases not only incorporate amino acids, but also various building... blocks present in fatty acids and polyketides. #12;Chapter 6 88 The operons encoding peptide ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 11 | insight review articles NATURE | VOL 409 | 11 JANUARY 2001 | www.nature.com 247 | ||
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Summary: of function mutagenesis of a modular polyketide synthase II. Engineered biosynthesis of an eight-membered ring... polyketide biosynthesis. Science 252, 675679 (1991). Acknowledgements Research on modular enzymes in C... insight review articles NATURE | VOL 409 | 11 JANUARY 2001 | www.nature.com 247 A ... |
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Source: Harbury, A. B. - Department of Biochemistry, Stanford University |
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Collection: Biology and Medicine |
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| 12 | Curriculum Vitae, Yiqiang (Eric) Cheng August 2010 Page 1 of 5 I. PERSONAL INFORMATION | ||
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Summary: pathway revealing cross-talk between modular polyketide synthases and fatty acid synthase (under review... of Bacteriology 184:7013-7024. (IF=3.6) 9. Cheng, Y.-Q., G.-L. Tang and B. Shen* (2003) Type I polyketide synthase... requiring a discrete acyltransferase for polyketide biosynthesis. Proceedings of the ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 13 | David H. Sherman, PhD Research Professor (Life Sciences Institute) | ||
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Summary: .85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1... .H. and M. Haygood. 2004. bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial... method for creation and functional analysis of libraries of hybrid type I ... |
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Source: Miami, University of - Rosenstiel School of Marine and Atmospheric Sciences, Fisheries Ecosystem Modeling and Assessment Research Group |
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Collection: Environmental Sciences and Ecology |
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| 14 | Science Highlight March 2010 Deadly Carcinogen Unraveled: The Molecular Origami of Fungal Polyketides | ||
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Summary: Polyketides Aflatoxin is an unavoidable food contaminant in grains and nuts produced in developing countries... belong to a class of natural products called polyketides, which are biosynthesized in many bacteria... and fungi (1,2). Polyketide natural products produced by bacteria and fungi are often characterized |
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Source: Wechsler, Risa H. - Kavli Institute for Particle Astrophysics and Cosmology, Stanford Linear Accelerator Center |
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Collection: Physics |
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| 15 | Chemistry & Biology, Vol. 11, 3345, January, 2004, 2004 Elsevier Science Ltd. All rights reserved. DOI 10.1016/j.chembiol.2003.12.014 Leinamycin Biosynthesis Revealing Unprecedented | ||
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Summary: Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase is mediated... nonribosomal pep- tide synthetase (NRPS), polyketide synthase (PKS), hy- of natural products by genetic... Q and LnmP) and modular (LnmI) NRPS, acyltransferase-less PKS (LnmG, LnmI, product biosynthetic gene |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 16 | Abstract A Tn5-1063-derived mutant of Nostoc puncti-forme strain ATCC 29133 was unable to fix N2 in air al- | ||
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Summary: . These active sites are characteristic of polyketide and fatty acid synthases. The N. punctiforme strain 29133... glycolipids follows a pathway characteristic of polyketide synthesis and involves similar large, multienzyme... complexes. Key words Fox mutant · Heterocyst glycolipid · hglE · Nostoc punctiforme · Polyketide ... |
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Source: Cohen, Michael F. - Department of Biology, Sonoma State University |
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Collection: Biology and Medicine |
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| 17 | Structure, Vol. 11, 147154, February, 2003, 2003 Elsevier Science Ltd. All rights reserved. PII S0969-2126(03)00004-2 Catalysis, Specificity, and ACP Docking Site | ||
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Summary: (MAT), the fabD gene Results and Discussionproduct of Streptomyces coelicolor A3(2), participates... mM sodium acetate (pH of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its... .R., and McDaniel, R. (2001). Alteration of the substrate speci- ficity of a modular ... |
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Source: |
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Collection: Biology and Medicine |
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| 18 | Columbia University Department of Chemistry Colloquia, Fall 2005 | ||
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Summary: Lecture "Modular Polyketide Synthases: Biochemical and Structural Basis for the (Monday) Programming |
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Source: Lin, Qiao - Department of Mechanical Engineering, Columbia University |
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Collection: Engineering ; Materials Science |
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| 19 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Feb. 2011, p. 15011507 Vol. 77, No. 4 0099-2240/11/$12.00 doi:10.1128/AEM.01513-10 | ||
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Summary: . Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases... modular nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) pathway for the biosynthesis... Streptomyces coelicolor A3(2) and analysis of its ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 20 | Curriculum Vitae, Yi-Qiang (Eric) Cheng October 2011 Page 1 of 9 I. PERSONAL INFORMATION | ||
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Summary: cross-talk between modular polyketide synthases and fatty acid synthase. Applied and Environmental... * (2003) Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis... .3) 10. Du, L., Y.-Q. Cheng, G. Ingenhorst, G.-L Tang, Y. Huang and B. Shen* (2003) Hybrid ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 21 | Research Paper Cloning and characterization of a phosphopantetheinyl transferase | ||
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Summary: prepared from ¢ve di¡erent Strepto- myces species. S. coelicolor A3(2) was chosen as a positive control... Biolabs, Beverly, MA, USA), S. albus JA 3453 [48], S. atroolivaceus [47], S. coelicolor A3(2) [55], S... verticillus ATCC15003, the producer of the hybrid peptide^polyketide ... |
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Source: Toney, Michael - Department of Chemistry, University of California, Davis |
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Collection: Chemistry ; Biology and Medicine |
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| 22 | Identification of the Putative Bryostatin Polyketide Synthase Gene Cluster from "Candidatus Endobugula sertula", the Uncultivated Microbial Symbiont of the Marine Bryozoan | ||
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Summary: present the putative biosynthetic genes: five modular polyketide synthase (PKS) genes, a discrete... such as the bryostatins are synthesized by modular polyketide synthases (PKS). Modular PKSs are typically only found... . The bry cluster in deep and shallow "E. sertula". ... |
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Source: Haygood, Margo G. - Division of Environmental and Biomolecular Systems, Oregon Health and Science University |
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Collection: Biotechnology ; Environmental Sciences and Ecology |
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| 23 | Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis | ||
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Summary: in the resultant polyketide products (2, 3). This one-to-one correspondence between the modularity of enzyme... Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis Yi... , and approved January 10, 2003 (received for review December 2, 2002) Type I ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 24 | Gene 237 (1999) 403411 www.elsevier.com/locate/gene | ||
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Summary: in the modular polyketide It is, in fact, common for antibiotic-producing organisms synthase. Gene 169, 9... similarity to acyl- CoA dehydrogenases and polyketide synthases, respectively. Insertional inactivation... ; Acyltransferases; Polyketide synthases; Self-resistance 1. Introduction tion nor RNA ... |
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Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 25 | Dissection of Malonyl-Coenzyme A Decarboxylation from Polyketide Formation in the Reaction Mechanism of a Plant Polyketide Synthase | ||
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Summary: Dissection of Malonyl-Coenzyme A Decarboxylation from Polyketide Formation in the Reaction... Mechanism of a Plant Polyketide Synthase Joseph M. Jez, Jean-Luc Ferrer, Marianne E. Bowman, Richard A... in polyketide formation and elucidate the importance of His303 and Asn336 in the malonyl-CoA decarboxylation |
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Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 26 | Copyright 2005 by the American Society for Biochemistry and Molecular Biology, Inc. This article is available online at http://www.jlr.org Journal of Lipid Research Volume 46, 2005 839 | ||
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Summary: · sphingolipids · sterol lipids · prenol lipids · saccharolipids · polyketides The goal of collecting data... , polyketides, etc.) and/or by carbocation-based condensa- tions of isoprene units (prenols, sterols, etc... as polyketides, acylglycerols, sphingolip- ids, prenols, or saccharolipids. However, for historical |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 27 | Natural insights for chemical biologists Christopher T Walsh | ||
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Summary: . Starting with the sequence of the erythro- mycin gene cluster2,3, the rules for modular assembly of malonyl... - and methylmalonyl-CoA monomers into thousands of structural vari- ants of polyketides have been delineated4... and matches assembly-line elements, and the underlying chemistry for making polyketidenonribosomal ... |
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Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine |
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| 28 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jan. 2004, p. 104113 Vol. 70, No. 1 0099-2240/04/$08.00 0 DOI: 10.1128/AEM.70.1.104113.2004 | ||
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Summary: myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide... similarity to genes involved in peptide and polyketide antibiotic biosynthesis. The mutant that overproduced... intermediates. Additionally, nonribosomal peptide synthetase (NRPS) and polyketide ... |
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Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 29 | The Iromycins, a New Family of Pyridone Metabolites from Streptomyces sp. I. Structure, NOS Inhibitory Activity, and | ||
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Summary: propionate units, presumably condensed by a type I modular polyketide synthase. In contrast, 3 and 4... -labeled precursors indicated an uncommon type of polyketide biosynthesis and clearly ruled out... observation and here we demonstrate it with the iromycin family. Introduction Polyketides are ... |
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Source: Müller, Peter - Department of Chemistry, Massachusetts Institute of Technology (MIT) |
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Collection: Chemistry |
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| 30 | Z .Comparative Biochemistry and Physiology Part B 128 2001 445 450 Purification and characterization of the fatty acid | ||
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Summary: . Rev. 97, 2525 2535. Katz, L., 1997. Manipulation of modular polyketide synthases. Chem. Rev. 97, 2557... .acid synthases and polyketide synthases PKS Z .Smith, 1994 , and the greater relative abundance... entry into the enzymology of this bryozoan. PKSs from bacteria consist of either a Z .modular type I |
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Source: Kerr, Russell G. - Department of Chemistry and Biochemistry, Florida Atlantic University |
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Collection: Biology and Medicine ; Chemistry |
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| 31 | Chemistry & Biology Genome-Wide High-Throughput Mining | ||
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Summary: design and rearrange- ment of modular polyketide synthase genes. Nat. Biotechnol. 23, 11711176. 12... encoding the natural-product biosynthetic enzymes, polyketide synthases (PKSs) and non- ribosomal peptide... , that inhabit virtually every niche of the biosphere. Among them, polyketide synthase (PKS) and ... |
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Source: Yin, Jun - Department of Chemistry, University of Chicago |
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Collection: Chemistry |
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| 32 | Vol 436|18 August 2005 RESEARCH HIGHLIGHTS | ||
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Summary: .1038/nbt1128 (2005) Escherichia coli bacteria have been engineered to make novel polyketides -- molecules... that can kill bacteria and inhibit cancer cells -- using a modular approach. Typically, soil microorganisms... make polyketides using hefty enzymes encoded in genetic sequences up to 50,000 bases long. To make |
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Source: Hamilton, Douglas P. - Department of Astronomy, University of Maryland at College Park |
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Collection: Physics |
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| 33 | Alexeev, I., A. Sultana, P. Mantsala, J. Niemi, and G. Schneider. 2007. Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site. Proc. Natl. Acad. Sci. U. | ||
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Summary: coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues and has a preference... . 2002. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417... and developmental biology of its host, Streptomyces coelicolor ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 34 | EVOLUTION OF PROTEIN FUNCTION BY DOMAIN SWAPPING | ||
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Summary: in modular proteins (McLachlan, 1987). The two possible evolutionary outcomes for such duplications... that chymotrypsin evolved by tandem duplication, although no detectable sequence similarity remains. 3. Modular... Proteins Modular proteins are described as displaying a beads-on-a-string orga- nization of domains |
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Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University |
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Collection: Biology and Medicine ; Biotechnology ; Chemistry |
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| 35 | Mechanism of Chalcone Synthase pKa OF THE CATALYTIC CYSTEINE AND THE ROLE OF THE CONSERVED HISTIDINE IN A PLANT | ||
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Summary: HISTIDINE IN A PLANT POLYKETIDE SYNTHASE* Received for publication, September 19, 2000 Published, JBC Papers... Polyketide synthases (PKS) assemble structurally di- verse natural products using a common mechanistic... strategy that relies on a cysteine residue to anchor the polyketide during a series of decarboxylative |
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Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 36 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Aug. 2004, p. 49214929 Vol. 70, No. 8 0099-2240/04/$08.00 0 DOI: 10.1128/AEM.70.8.49214929.2004 | ||
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Summary: esters from PKC by bryostatin (32). Macrolide polyketides like bryostatins are produced by type I modular... of the bryostatins, polyketides that provide chemical defense to the host and are also being tested for use in human... polyketide synthase (PKS) primers amplified a gene fragment from B. simplex that ... |
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Source: Haygood, Margo G. - Division of Environmental and Biomolecular Systems, Oregon Health and Science University |
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Collection: Biotechnology ; Environmental Sciences and Ecology |
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| 37 | Evidence for Catalytic CysteineHistidine Dyad in Chalcone Synthase | ||
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Summary: ) A chain initiation factor common to both modular and aromatic polyketide synthases. Nature 401, 502 505... synthase (STS, EC 2.3.1.95) are multifunctional plant polyketide synthases (PKS) (1). The amino acid se... pyrocarbonate; Idm, iodoacetamide; KS, 3-ketoacyl-(acyl carrier protein) synthase; PKS, ... |
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Source: Suh, Dae-Yeon - Department of Chemistry and Biochemistry, University of Regina |
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Collection: Chemistry |
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| 38 | Elucidating the Substrate Specificity and Condensation Domain Activity of FkbP, the FK520 Pipecolate-Incorporating Enzyme | ||
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Summary: polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) systems in streptomycetes. An important... polyketide chain by the action of RapP/FkbP, a four-domain NRPS that also putatively serves to cyclize... of two related enzyme families: nonribosomal peptide synthetases (NRPSs)1 and polyketide synthases (PKSs |
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Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine |
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| 39 | Research Paper Analysis of the prodiginine biosynthesis gene cluster of | ||
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Summary: Research Paper Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2... reserved. Keywords: Antibiotic; Fatty acid synthase; Modular polyketide synthase; Non-ribosomal peptide... by Streptomyces coelicolor A3(2) was ¢rst discovered ... |
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Source: Bibb, Mervyn - Department of Molecular Microbiology, John Innes Centre |
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Collection: Biology and Medicine |
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| 40 | Bacillus subtilispathway ofpksXproteins in the -carrierSConvergence of isoprene and polyketide biosynthetic machinery: Isoprenyl- | ||
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Summary: Bacillus subtilispathway ofpksXproteins in the -carrierSConvergence of isoprene and polyketide... of isoprene and polyketide biosynthetic machinery: Isoprenyl-S-carrier proteins in the pksX pathway... is predicted to encode the biosynthesis of an as yet uncharacterized hybrid nonribosomal pep- tide polyketide |
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Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine |
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| 41 | Although acetaminophen (para-cetamol) has been used clinically | ||
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Summary: Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes... products by altering or replacing individual polyketide synthase (PKS) gene modules is laborious and time... -consuming. Menzella et al. present a combinatorial method for producing ... |
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Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 42 | Introduction Chapter one | ||
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Summary: modification of thiolation domains of peptide synthetases, modular fatty acid synthases and polyketide... with the polyketide synthetases, are the largest proteins present in the cell. Genetic and biochemical analyses... of many peptide synthetases have revealed that these multifunctional proteins exhibit a ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 43 | Molecular Microbiology (2000) 37(5), 989994 MicroOpinion | ||
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Summary: in microorganisms comes from a study of polyketide synthases (PKS) (Hutchinson, 1999; Shen et al., 1999... ). This tolerance not only allows each unit of the modular pathway to accept a wide range of substrates, but it also... of the . 3000 polyketides known in nature, but also provides a rational basis for further attempts to ... |
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Source: Jones, Clive G. - Cary Institute of Ecosystem Studies |
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Collection: Environmental Sciences and Ecology |
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| 44 | DOI: 10.1126/science.1155313 , 239 (2008);320Science | ||
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Summary: in cultured rat car- diomyocytes. (A) Modular organization of Lmod and constructsusedinthisstudy (TM-h1, TM-h2... ; accepted 19 February 2008 10.1126/science.1155313 Deconstruction of Iterative Multidomain Polyketide... aflatoxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood |
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Source: Pollard, Thomas D.- Department of Molecular, Cellular and Developmental Biology, Yale University |
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Collection: Biology and Medicine |
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| 45 | HARNESSING PLANT BIOMASS FOR BIOFUELS AND BIOMATERIALS Nature's assembly line: biosynthesis of simple | ||
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Summary: of simple phenylpropanoids and polyketides Oliver Yu* and Joseph M. Jez Donald Danforth Plant Science Center... and absolute quantity of these compounds. The phenylpropanoids, and the related plant polyketides, have... -groups of these polyphenolic compounds polyketides, stilbenes, isoflavones and catechins. We discuss the ... |
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Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 46 | SSB pushed off free DNA end | ||
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Summary: 21 October 1909. BIOCHEMISTRY Enzyme'sblackboxcrackedopen David H. Sherman Polyketide synthase... of the enzymes' ability to use such unstable precursors has been laid bare. Polyketides form a structurally... -lowering drug lovastatin. But it's not all good news. Some polyketides are dangerous, such as aflatoxin B1 |
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Source: Cistola, David P. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis; Lohman, Timothy M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 47 | he primary goal of protein engineering is to cre-ate a novel protein Y that possesses some improved | ||
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Summary: peptides30, polyketides31 and terpenes32, have also been amenable to hybrid-enzyme manipulation, owing... to their modular nature. Nonribosomal synthe- sis of peptide secondary metabolites is catalysed by multifunctional... amino acid substitutions. Polyketides are a group of secondary metabolites constructed through |
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Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University |
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Collection: Biology and Medicine ; Biotechnology ; Chemistry |
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| 48 | Thioesterase Portability and Peptidyl Carrier Protein Swapping in Yersiniabactin Synthetase from Yersinia pestis | ||
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Summary: , including polyketide synthases (PKSs), nonribosomal peptide syn- thetases (NRPSs), and mixed PKS... proteins and lessons for protein engineering in generating novel modular enzymes were discussed. Yersinia... to convert salicylate, three cysteines, and malonyl-CoA into the mixed nonribosomal peptide/polyketide Ybt |
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Source: Suo, Zucai - Department of Biochemistry, Ohio State University |
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Collection: Biology and Medicine |
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| 49 | JOURNAL OF BACTERIOLOGY, Dec. 2002, p. 70137024 Vol. 184, No. 24 0021-9193/02/$04.00 0 DOI: 10.1128/JB.184.24.70137024.2002 | ||
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Summary: of the model actino- mycete Streptomyces coelicolor A3(2). Nature 417:141147. 3. Bierman, M., R. Logan, K. O... -containing hybrid peptide- polyketide natural product structurally characterized with an unprecedented 1,3-dioxo-1... I is characterized by domains characteristic to both NRPS and polyketide ... |
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Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 50 | Nostoc punctiforme is a filamentous cyanobacterium capable of forming symbiotic | ||
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Summary: and polyketide synthases. We intend to test the functionality of these clusters and a possible involvement... ., Hinrichs, K., Stangeland, J., Hertweck, C., Dittmann, E. (2011) A polyketide interfers with cellular |
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Source: Potsdam, Universität - Institut für Physik, Arbeitsgruppe Nichtlineare Dynamik |
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Collection: Physics |
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| 51 | Cyanobacteria are known as a prolific source of secondary metabolites exhibiting unique | ||
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Summary: ) Evolution of metabolic diversity: Insights from microbial polyketide synthases. Phytochem. 70... ., Hertweck, C., Piel, J. (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases... -Kodama, H., He, J., Dittmann, E., Hertweck, C. (2007) Non-Colinear Polyketide Biosynthesis in the Aureothin |
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Source: Potsdam, Universität - Institut für Physik, Arbeitsgruppe Nichtlineare Dynamik |
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Collection: Physics |
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| 52 | Molecular Biotechnology LaboratoryMolecular Biotechnology Laboratory (Prof. Nancy Da Silva)(Prof. Nancy Da Silva) | ||
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Summary: of PolyketidesMetabolic Engineering of Yeast for the Synthesis of Polyketides Synthesis of CellSynthesis of Cell |
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Source: George, Steven C. - Department of Biomedical Engineering, University of California, Irvine |
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Collection: Biology and Medicine |
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| 53 | Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms | ||
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Summary: Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery... . Enzyme Machinery 3474 3.1. Polyketide Synthase Enzymatic Machinery: Canonical Organization 3474 3... molecule natural products with interesting biological activities are polyketides (PK), non- ribosomal |
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Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine |
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| 54 | Excision of the Epothilone Synthetase B Cyclization Domain and Demonstration of in Trans Condensation/Cyclodehydration Activity | ||
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Summary: anticancer natural products produced by a polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS... for introduction of the thiazoline heterocycle into the growing polyketide/nonribosomal peptide chain from... (NRPSs)1 and polyketide synthases (PKSs) are large, multimodular enzymes respon- sible |
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Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine |
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| 55 | SMURF: Genomic mapping of fungal secondary metabolite clusters Nora Khaldi a | ||
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Summary: Keywords: NRPS PKS Prenyltransferases Polyketides Antibiotics Secondary metabolism Filamentous fungi... refer to here as ``backbone" en- zymes. They include nonribosomal peptide synthases (NRPSs), polyketide... : nonribosomal peptides, polyketides, NRPSPKS hybrids, indole alkaloids, and terpenes (Hoffmeister and Keller |
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Source: Wolfe, Kenneth H. - Genetics Department, Trinity College, University of Dublin |
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Collection: Biotechnology ; Environmental Sciences and Ecology |
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| 56 | General introduction Submitted for publication together with chapter 5 | ||
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Summary: coelicolor A3(2) has consolidated as the model organism within the streptomycetes (Chater, 2006... prototrophic derivative of A3(2) lacking the two S. coelicolor plasmids SCP1 and SCP2) has been published... (Hesketh et al., 2007). There are many more A3(2) derived ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 57 | Mycosubtilin operon Chapter two | ||
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Summary: synthetases have revealed a modular structure of these multifunctional proteins (Ullrich et al.,1991; Scott... - configuration to the D-configuration (De Crécy-Lagard et al., 1995; Stein et al., 1995). The conserved modular... synthetase genes revealed a typical modular structure, and indicated that the isolated DNA fragment ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 58 | group from The Institute for Genomic Research (Ravel and Eisen), and in the course of our studies we rationally | ||
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Summary: -producing actinomycetes. Patent WO2004013297 7 Hildebrand, M. et al. (2004) bryA: an unusual modular polyketide synthase... . (2004) Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes... , 15431552 8 Piel, J. et al. (2004) Antitumor ... |
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|
Source: Ziegler, Kirk J. - Chemical Engineering Department, University of Florida |
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Collection: Materials Science |
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| 59 | 10.1021/ol103117j r 2011 American Chemical Society Published on Web 02/16/2011 | ||
|
Summary: , 2011 ABSTRACT A potentially biomimetic approach toward the complex polyketide A-74528 is described... polyketides known to date. Interestingly, the biosynthetic machinery responsible for its formation is very... similar to the type II polyketide synthase that accounts for the formation of fredericamycin (2 |
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|
Source: Trauner, Dirk - Department Chemie, Ludwig Maximilians Universität München |
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Collection: Chemistry |
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| 60 | TRENDS in Biochemical Sciences Vol.27 No.9 September 2002 http://tibs.trends.com 0968-0004/02/$ see front matter 2002 Elsevier Science Ltd. All rights reserved. PII: S0968-0004(02)02168-0 | ||
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Summary: chain initiation factor common to both modular and aromatic polyketide synthases. Nature 401, 502505 45... of docosahexaenoic acid (22:6) in mammals and a polyketide synthase pathway in marine microbes. Published online: 15... , and instead uses a polyketide synthase to produce 20:5n3 and 22:6n3 [15]. ... |
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|
Source: Watts, Jennifer - School of Molecular Biosciences, Washington State University |
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Collection: Biology and Medicine |
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| 61 | RESEARCH ARTICLES DothideomycetePlant Interactions Illuminated by Genome | ||
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Summary: of expression. Polyketide synthases (PKSs) are a second modular gene family strongly associated... ,762 nuclear genes. Extensive orthology was found between the polyketide synthase family in S. nodorum... libraries. Nonribosomal peptide synthetases (NRPSs) are modular en- zymes that synthesize a diverse set |
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|
Source: McDonald, Bruce - Institut für Integrative Biologie, Eidgenössische Technische Hochschule Zürich (ETHZ) |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 62 | Probing Intra-versus Interchain Kinetic Preferences of L-Thr Acylation on Dimeric VibF with Mass Spectrometry | ||
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Summary: nonribosomal peptide synthetases, and to the related fatty acid and polyketide synthases, will further our... ), and polyketide synthases (PKSs), and much effort has been placed on understanding the mechanisms... of polyketide synthases and nonribosomal peptide synthe- tases. Chem. Biol. 6:R319R325. 2. Cane, D. E., C. T |
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|
Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine |
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| 63 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, June 2007, p. 34603469 Vol. 73, No. 11 0099-2240/07/$08.00 0 doi:10.1128/AEM.01751-06 | ||
|
Summary: . 968 genomic DNA clones that code for portions of nonribosomal peptide synthetase and polyketide... synthetase-polyketide synthase-nonribosomal peptide synthetase assembly line includ- ing accessory activities... derived from malonyl coenzyme A (MCoA). These observations suggest a hybrid nonribosomal peptide (NRP)-polyketide |
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|
Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee |
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Collection: Biology and Medicine |
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| 64 | Nonribosomal peptide synthesis in Bacillus subtilis | ||
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Summary: modification of thiolation domains of peptide synthetases, modular fatty acid synthases and polyketide... with the polyketide synthetases, are the largest proteins present in the cell. Genetic and biochemical analyses... of many peptide synthetases have revealed that these multifunctional proteins exhibit a ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 65 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 0099-2240/01/$04.00 0 DOI: 10.1128/AEM.67.10.45314537.2001 | ||
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Summary: metabolites synthesized by modular type I polyketide synthases (PKS-I). PKS-I gene fragments were cloned from... is the most likely source of bryostatins. Bryostatins are complex polyketides similar to bacterial secondary... . neritina is the sole source of this unique family of macrolides. The bryostatins are complex ... |
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|
Source: Haygood, Margo G. - Division of Environmental and Biomolecular Systems, Oregon Health and Science University |
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Collection: Biotechnology ; Environmental Sciences and Ecology |
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| 66 | Regulation of secondary metabolism in streptomycetes Mervyn J Bibb | ||
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Summary: polyketide biosynthetic cluster of Streptomyces coelicolor A3(2). Mol Microbiol 2005: in press. Comprehensive... coelicolor A3(2): new mechanisms for chain initiation and termination in modular multi-enzymes. Chem Biol... for antibiotic production under conditions of ... |
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Source: Bibb, Mervyn - Department of Molecular Microbiology, John Innes Centre |
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Collection: Biology and Medicine |
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| 67 | Chemoenzymatic Approaches for Streamlined Detection of Active Site Modifications on Thiotemplate Assembly Lines Using Mass Spectrometry | ||
|
Summary: scaffolds known as nonribosomal peptide synthetases (NRPSs)1 and polyketide synthases (PKSs) (1... pharmaceuticals is accelerating rapidly. The "modular" configuration of NRP/PK synthetases has sparked an interest... of Illinois. § Harvard Medical School. 1 Abbreviations: NRPS, nonribosomal peptide synthetase; PKS, polyketide |
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|
Source: Yin, Jun - Department of Chemistry, University of Chicago |
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Collection: Chemistry |
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| 68 | The ultimate rendezvous: microbial ecology meets industrial biotechnology | ||
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Summary: of polyketides, one of the research areas where the power of generating and shuffling gene libraries was first... shown. This is because these antibiotics are non-ribosomal peptides typically produced by multi- modular |
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|
Source: Sheridan, Jennifer - Women in Science and Engineering Leadership Institute, University of Wisconsin at Madison |
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|
Collection: Multidisciplinary Databases and Resources |
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| 69 | Molecular Cell, Vol. 16, 881891, December 22, 2004, Copyright 2004 by Cell Press A Mechanism for the Potent Inhibition of Eukaryotic | ||
|
Summary: for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme A Carboxylase by Soraphen A, a Macrocyclic Polyketide... ) (Abu-Elheiga et al., 2001; Lenhard and Gottschalk,clic polyketide natural product, is a nanomolar... .,structure-based design of new inhibitors against 1994, 2003). This polyketide natural product contains anthese ... |
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|
Source: Tong, Liang - Department of Biological Sciences, Columbia University |
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Collection: Biology and Medicine |
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| 70 | Structural and Functional Analysis of Tetracenomycin F2 Cyclase from Streptomyces glaucescens | ||
|
Summary: A TYPE II POLYKETIDE CYCLASE* Received for publication, June 2, 2004, and in revised form, June 28, 2004... to be the active site. This type of secondary structural arrangement has been previously observed in polyketide... into the structural framework necessary to per- form the complex rearrangements catalyzed by this class of ... |
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|
Source: Rayment, Ivan - Department of Biochemistry, University of Wisconsin at Madison |
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Collection: Chemistry ; Biology and Medicine |
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| 71 | Extracting the hierarchical organization of complex systems | ||
|
Summary: is not locally dense (Fig. 2). We propose a new affinity measure based on the surveying of the modularity... (18, 19), and assign to each partition P P the modularity M P i 1 m li L di 2L 2 , [1] where L... . 1A). The modularity of a partition is high when the number of intramodule links is much larger than |
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|
Source: Amaral, Luis A.N. - Department of Chemical and Biological Engineering, Northwestern University |
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Collection: Physics ; Biology and Medicine |
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| 72 | De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model | ||
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Summary: . macrospora contains more polyketide biosynthesis genes than N. crassa. Phylogenetic analyses suggest |
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|
Source: Kück, Ulrich - Fakultät für Biologie, Ruhr-Universität Bochum |
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Collection: Biology and Medicine |
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| 73 | Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes | ||
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Summary: that function as molecular assembly lines. The modular architecture of NRPSs suggests that a domain responsible... , including one that produces new derivatives of the potent NRP/ polyketide antibiotic andrimid. Because... challenging hosts. nonribosomal peptide polyketide Many small molecules with important biological activities |
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|
Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University |
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Collection: Chemistry ; Biology and Medicine |
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| 74 | Swaps in Protein Sequences Amit Fliess, Benny Motro, and Ron Unger* | ||
|
Summary: . This observation is at odds with the common view that proteins are very modular to the point that modules (e... ). The cases of fatty-acid synthases (FAS2_CANAL and FAS_CHICK, Table I, 2.) and polyketide synthases [MSAS... recorded in our study, the swapping fragments were identified as distinct modular domains known |
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Source: Unger, Ron - Faculty of Life Sciences, Bar Ilan University |
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Collection: Biology and Medicine |
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| 75 | RESEARCH Open Access Comparative genomics of the social amoebae | ||
|
Summary: others, such as the polyketide synthases, have undergone extensive diversification. The abundant amino... . Polyketide synthases Polyketide synthases (PKSs) are enzymatic production lines for making small molecules... of polyketides exist and are probably made for ecological purposes, but they also serve as ... |
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|
Source: Babu, M. Madan - Laboratory of Molecular Biology, MRC |
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Collection: Biotechnology |
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| 76 | Subscriber access provided by SCRIPPS RSRCH INST ACS Chemical Biology is published by the American Chemical Society. 1155 Sixteenth | ||
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Summary: of polyketide synthases (PKS) and nonribosomal peptide synthetase (NRPS) biosynthetic pathways and our... -sites to provide activity-based enrichment of modular synthases, followed by analysis through multidimensional... Bacillus subtilis, this functional proteomics method detects and quantifies all four modular synthases |
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Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
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Collection: Biology and Medicine |
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| 77 | The plant phenylpropanoid pathway provides anthocyanins used for pigmentation and protection against UV photodam- | ||
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Summary: @sbl.salk.edu Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis Jean-Luc Ferrer1... . It produces chalcone by condensing one p-coumaroyl- and three malonyl- coenzyme A thioesters into a polyketide... the chemical basis of plant polyketide biosynthesis and provides a framework for engineering ... |
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|
Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 78 | Structurally diverse natural products that cause potassium leakage trigger multicellularity in | ||
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Summary: formation in LB. After testing a relatively small panel of compounds, we found that the polyene polyketide... ). To decipher how B. subtilis senses nystatin, we attempted to define the properties of this polyene polyketide... is also a polyene polyketide, but it differs from nystatin in its functionality. Filipin does not form |
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|
Source: Losick, Richard M. - Department of Molecular and Cellular Biology, Harvard University |
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Collection: Biotechnology ; Biology and Medicine |
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| 79 | RESEARCH ARTICLE Open Access The dynamic architecture of the metabolic | ||
|
Summary: T, associated with Streptomyces coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues... strain and cultivation conditions Experiments were performed using S. coelicolor A3(2) strain M145 [26... in morphological differentiation and antibiotic ... |
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|
Source: Breitling, Rainer - Groningen Bioinformatics Centre, Rijksuniversiteit Groningen |
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Collection: Biology and Medicine ; Biotechnology |
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| 80 | 1 Copyright 2000 by ASME Proceedings of DETC2000 | ||
|
Summary: element electric automotive vehicle power train modular model equations (32a-32b). Form of the unconnected... matrix T to (32a-32b) to partition the inputs and outputs internally and externally. Apply the internal... (39) has the same input-output topology (Fig. 4) as the linear ... |
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|
Source: Radcliffe, Clark J. - Department of Mechanical Engineering, Michigan State University |
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Collection: Engineering |
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| 81 | Regulation of antibiotic production in Streptomyces coelicolor A bacterial hormone receptor variant and | ||
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Summary: coelicolor A3(2) has consolidated as the model organism within the streptomycetes (Chater, 2006... prototrophic derivative of A3(2) lacking the two S. coelicolor plasmids SCP1 and SCP2) has been published... (Hesketh et al., 2007). There are many more A3(2) derived ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 82 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Sept. 2007, p. 55235530 Vol. 73, No. 17 0099-2240/07/$08.00 0 doi:10.1128/AEM.00577-07 | ||
|
Summary: via modular polyketide synthase and nonribosomal peptide synthetase (NRPS) megasynthases, and NRPS... three large polyketide syn- thase (PKS) and nonribosomal peptide synthetase (NRPS) genes. Transposon... is responsible for a discrete stage of polyketide or polypeptide chain elongation (7). Moreover, each ... |
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|
Source: Mondolot, Laurence - Centre dEcologie Fonctionnelle et Evolutive, Université Montpellier I |
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Collection: Biology and Medicine |
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| 83 | INTRODUCTION Synthetic biology: history, challenges | ||
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Summary: parts and modular construction methods. Engineers were then free to reap the benefits of abstraction... , resulting in robust pattern formation. The modularity of RNA-based logic gates/switches is also seen... to be robust. Examples include phosphoryl- ation-based signalling cascades, polyketide synthase `assembly lines |
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|
Source: Haseloff, Jim - Department of Plant Sciences, University of Cambridge |
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Collection: Biology and Medicine |
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| 84 | Department of Chemistry, University of Connecticut, Storrs Fall 2011 Seminar Schedule | ||
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Summary: . Kumar Sept. 21 Professor Nate Schnarr Simplified Approaches for Improved Control Over Polyketide |
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|
Source: Michel, Robert G. - Department of Chemistry, University of Connecticut |
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Collection: Chemistry |
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| 85 | Multiplex Sequencing of 1.5 Mb of the Mycobacterium leprae Genome | ||
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Summary: therapeutic and vaccine targets. Unusual features of the M. leprae genome include large polyketide synthase... members of a family of polyketide synthase (pks) genes (including four within a single large operon... , separated by 3.8 kb, are con- tained in two adjacent polyketide synthase genes encoded by the L518 operon |
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|
Source: Church, George M. - Wyss Institute for Biologically Inspired Engineering & Department of Genetics, Harvard University |
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Collection: Biotechnology |
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| 86 | Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter | ||
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Summary: Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter... for review November 4, 2001) Type III polyketide synthases (PKS) generate an array of natural products... of these biosynthetic enzymes involves modifying polyketide assembly by altering the preference for starter molecules |
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|
Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 87 | School of Chemistry 2009 -Highlight Papers | ||
|
Summary: in the actinorhodin minimal polyketide synthase P. Beltran-Alvarez, C. J. Arthur, R. J. Cox, J. Crosby, M. P. Crump... with other components of the actinorhodin minimal polyketide synthase was examined using steady state kinetic... partners in the polyketide synthase complex. Earliest horse harnessing and milking A.K. Outram, ... |
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|
Source: Bristol, University of - School of Geographical Sciences, Bristol Glaciology Centre |
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Collection: Environmental Sciences and Ecology ; Geosciences |
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| 88 | Autonomous multistep organic synthesis in a single isothermal solution mediated | ||
|
Summary: as pathways that generate polyketides and non-ribosomal peptides3,4, this strategy enables the sequence... to a target. Nature Methods 4, 269279 (2007). 3. Walsh, C. T. Polyketide and nonribosomal peptide antibiotics... : modularity and versatility. Science 303, 18051810 (2004). 4. Sattely, E. S., Fischbach, M. A. & ... |
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|
Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University |
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|
Collection: Chemistry ; Biology and Medicine |
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| 89 | Structure-Guided Programming of Polyketide Chain-Length Determination in Chalcone Synthase | ||
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Summary: Structure-Guided Programming of Polyketide Chain-Length Determination in Chalcone Synthase Joseph M... polyketide synthases (PKS) that catalyze formation of structurally diverse polyketides. CHS synthesizes... that is in direct contact with the polyketide chain derived from malonyl-CoA. Thus, position 256 ... |
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|
Source: Jez, Joseph - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 90 | Appl Microbiol Biotechnol (2004) 65: 473478 DOI 10.1007/s00253-004-1670-y | ||
|
Summary: contamination in cottonseed has a defective polyketide synthase gene Received: 28 January 2004 / Revised: 4 May... to competitively exclude aflatoxin-producing Aspergillus species. We now show that the polyketide synthase gene... two fatty acid synthases and a polyketide synthase necessary for the first steps in aflatoxin |
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|
Source: Cotty, Peter J. - School of Plant Sciences, University of Arizona |
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Collection: Biology and Medicine |
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| 91 | Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential | ||
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Summary: as building blocks of colonies with special modular organization (Figure 1 and Additional file 1 section I... ] are underpinned by a highly developed signal trans- duction system consisting of modular domains forming a network... purposes in the pharmaceutical industry. The PKS genes for a certain polyketide are usually organized |
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|
Source: Jacob, Eshel Ben - School of Physics and Astronomy, Tel Aviv University |
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|
Collection: Physics |
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| 92 | A truer measure of our ignorance Luis A. Nunes Amaral* | ||
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Summary: for networks with no internal structure (11). Work by numerous re- searchers on the detection of modular... acids Secondary metabolites Glycans Polyketides and nonribosomal peptides Cofactors and vitamins pep coa |
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|
Source: Amaral, Luis A.N. - Department of Chemical and Biological Engineering, Northwestern University |
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Collection: Physics ; Biology and Medicine |
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| 93 | Chemistry & Biology, Vol. 11, January, 2004, 2004 Elsevier Science Ltd. All rights reserved. DOI 10.1016/j.chembiol.2004.01.004 mountable competitive advantage over 10-23 and otherBreaking Up Is Easy To Do | ||
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Summary: on these data, Cruz In this issue of Chemistry & Biology, Cruz et al. use in et al. offer a modular structural... -vomycin, UCH9, and durhamycin A, are a family of aro- matic polyketides that share an identical tricyclic core |
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|
Source: Silverman, Scott K. - Department of Chemistry, University of Illinois at Urbana-Champaign |
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|
Collection: Chemistry ; Biology and Medicine |
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| 94 | Mutational Analysis of Conserved Outer Sphere Arginine Residues of Chalcone Synthase | ||
|
Summary: , outer sphere mutation, stilbene synthase, type III polyketide synthase, site-directed mutagenesis... ; PCS, pentaketide chromone synthase; PGO, phenylglyoxal; PKS, polyketide synthase; STS, stilbene... flavonoids (Fig. 1). CHS and homologous members of the CHS superfamily, also known as type III polyketide |
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|
Source: Suh, Dae-Yeon - Department of Chemistry and Biochemistry, University of Regina |
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|
Collection: Chemistry |
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| 95 | The circuit-like connectivity of biological parts and their ability to collectively process logical operations | ||
|
Summary: of modularization, rationalization and modelling, has progressed rapidly and generated an ever-increasing suite... ). The two basic sensing modules must be delicately balanced: this is achieved by programming modularity... Modularity The capacity of a system or component to function independently of context. Environment |
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|
Source: Collins, James J. - Wyss Institute for Biologically Inspired Engineering & Department of Biomedical Engineering, Boston University |
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Collection: Engineering ; Biotechnology |
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| 96 | 1. Abrhamova Z, Patek M & Nesvera J (2002) Atypical location of double-strand origin of replication (nic site) on the plasmid pGA1 from Corynebacterium | ||
|
Summary: of the model actinomycete Streptomyces coelicolor A3(2). Nature 417: 141-147. #12;References 98 10. Benveniste... of a second sex factor, SCP2, for Streptomyces coelicolor A3(2). Mol Gen Genet 154: 155-166. 14. Bibb MJ, Ward... sequence. Nature 393: 537-544. 31. Davis NK & Chater KF (1990) Spore colour ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 97 | Modulhandbuch Bachelor-Studiengang Biochemie Organische Chemie 1 | ||
|
Summary: , Nukleinsäuren, Terpene, Polyketide. Die oben aufgeführten Inhalte, speziell die Stoffgruppen und Konzepte |
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|
Source: Manstein, Dietmar J. - Department of Biophysical Chemistry, Medizinische Hochschule Hannover |
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Collection: Biology and Medicine |
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| 98 | CHEMISTRY 622 BIOSYNTHESIS OF PLANT NATURAL PRODUCTS | ||
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Summary: : shikimate, acetogenin (otherwise known as the polyketide) and terpenoid pathways. Alkaloids, while often... Chapter 5 The polyketide pathway 13-Oct 15-Oct 18-Oct Examples of biosynthetic studies involving... polyketides from the literature 20-Oct 22-Oct 25-Oct chapter 5 mixed pathways- the flavanoids 27-Oct oxidative |
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|
Source: Wagner, Diane - Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks |
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Collection: Environmental Sciences and Ecology |
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| 99 | Genetically Encoded Short Peptide Tags for Orthogonal Protein Labeling by Sfp and AcpS | ||
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Summary: alone as key parts of the biosynthetic machinery of nonribosomal peptide synthetases (NRPSs), polyketide... successive anchoring points for the attachment of the growing peptide, polyketide, or fatty acyl chains... - ence 282, 6368. 4. Marahiel, M. A., Stachelhaus, T., and Mootz, H. D. (1997) Modular peptide |
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|
Source: Yin, Jun - Department of Chemistry, University of Chicago |
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|
Collection: Chemistry |
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| 100 | R E V I E W A R T I C L E The complexextracellular biologyof Streptomyces | ||
|
Summary: of an antibiotic (streptomycin) (Horinouchi, 2007) and Streptomyces coelicolor A3(2), the most widely used... - duced family 18 chitinases and two family 19 chitinases, with various modular arrangements comprising |
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|
Source: Palmer, Tracy - Division of Molecular Microbiology, University of Dundee |
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|
Collection: Biology and Medicine |
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