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Sample search results for: a32 modular polyketide

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1 CHAITAN KHOSLA Wells H. Rauser and Harold M. Petiprin Professor
 

Summary:  of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)., J. Bacteriol., 177... .E. and Khosla, C., Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase... ring size by directed mutagenesis of a ...

  

Source: Stack, T. Daniel P. - Department of Chemistry, Stanford University

 

Collection: Chemistry

 
2 Structure and mechanism of chalcone synthase-like polyketide , J-L Ferrer2
 

Summary:  Structure and mechanism of chalcone synthase-like polyketide synthases JM Jez1 , J-L Ferrer2 , ME... Biology Division, Samuel Roberts Noble Foundation, P.O. Box 2180, Ardmore, OK 73402, USA Polyketide... and pharmacological properties by varying the starter and extender molecules that form the final polyketide. Recent

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
3 Structural control of polyketide formation in plant-specic polyketide synthases
 

Summary:  is released. Elongation of the polyketide occurs through either a modular or an iterative approach [7... factor common to both modular and aromatic polyketide synthases. Na- ture 401, 502^505. 35. Carreras, C... Structural control of polyketide formation in plant-speci¢c ...

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
4 Structure 14, 737748, April 2006 2006 Elsevier Ltd All rights reserved DOI 10.1016/j.str.2006.01.009 The Structure of a Ketoreductase Determines
 

Summary:  polyketide synthase acyl carrier protein from Strep- tomyces coelicolor A3(2). Biochemistry 36, 6000... . While some successes in engineering modular PKSs to produce novel polyketides have been reported... , C. (1996). A functional chimeric modular ...

  

Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
5 C H A P T E R E I G H T Type I Polyketide Synthases That
 

Summary:  Figure 8.1 Modular organization of type I polyketide synthases (PKSs). (A) A proto- typical type I PKS... modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula... ., and Khosla, C. (2003). Quantitative analysis of loading and extender acyltransferases of ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
6 Polyketide Chain Skipping Mechanism in the Biosynthesis of the Hybrid Nonribosomal Peptide-Polyketide Antitumor Antibiotic Leinamycin in Streptomyces atrooliWaceus S-140
 

Summary:  Ved NoVember 11, 2005 A fundamental feature of modular polyketide synthases (PKSs) is the highly... -methylation process. These findings provide new insights into the polyketide chain skipping mechanism for modular PKSs... in the resultant polyketide products.1,2 The collinearity between ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
7 Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin
 

Summary:  for review July 30, 2001) As the first structural elucidation of a modular polyketide synthase (PKS) domain... suggests that all TEs from modular polyketide synthases have a similar fold, dimer 2-fold axis... , and substrate channel geometry. Modular polyketide ...

  

Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
8 O O O O O O O Several products
 

Summary:  Me O O O O O O O OH a Several products Polyketide chain b HO OH O OH OH O Noranthrone (only product... modular PKSs. The authors also observe a clear binding region for the phosphopantetheine arm of Pks... A that guides polyketide substrates into the PT domain's binding pocket (Fig. 1b). Fur- thermore, by obtaining

  

Source: Hell, Stefan W. - Department of NanoBiophotonics, Max Planck Institute for Biophysical Chemistry; Heller, Eric - Departments of Chemistry & Physics, Harvard University

 

Collection: Chemistry ; Materials Science ; Physics

 
9 Protist, Vol. 159, 21--30, January 2008 http://www.elsevier.de/protis
 

Summary:  October 2007 ORIGINAL PAPER Novel Insights into Evolution of Protistan Polyketide Synthases through... Submitted November 27, 2006; Accepted July 31, 2007 Monitoring Editor: Herve´ Philippe Polyketide synthase... acid synthases involved in lipid metabolism. Polyketide biosynthesis of secondary metabolites and hence

  

Source: Gent, Universiteit - Department of Plant Systems Biology, Bioinformatics and Evolutionary Genomics Division

 

Collection: Biology and Medicine

 
10 Summary and general conclusions Chapter six
 

Summary:  is performed by large multienzyme complexes, designated peptide synthetases, which exhibit a modular structure... - or polyketide synthases. These hybrid synthetases not only incorporate amino acids, but also various building... blocks present in fatty acids and polyketides. #12;Chapter 6 88 The operons encoding peptide ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
11 insight review articles NATURE | VOL 409 | 11 JANUARY 2001 | www.nature.com 247
 

Summary:  of function mutagenesis of a modular polyketide synthase II. Engineered biosynthesis of an eight-membered ring... polyketide biosynthesis. Science 252, 675­679 (1991). Acknowledgements Research on modular enzymes in C... insight review articles NATURE | VOL 409 | 11 JANUARY 2001 | www.nature.com 247 A ...

  

Source: Harbury, A. B. - Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine

 
12 Curriculum Vitae, Yiqiang (Eric) Cheng August 2010 Page 1 of 5 I. PERSONAL INFORMATION
 

Summary:  pathway revealing cross-talk between modular polyketide synthases and fatty acid synthase (under review... of Bacteriology 184:7013-7024. (IF=3.6) 9. Cheng, Y.-Q., G.-L. Tang and B. Shen* (2003) Type I polyketide synthase... requiring a discrete acyltransferase for polyketide biosynthesis. Proceedings of the ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
13 David H. Sherman, PhD Research Professor (Life Sciences Institute)
 

Summary:  .85 Å structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1... .H. and M. Haygood. 2004. bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial... method for creation and functional analysis of libraries of hybrid type I ...

  

Source: Miami, University of - Rosenstiel School of Marine and Atmospheric Sciences, Fisheries Ecosystem Modeling and Assessment Research Group

 

Collection: Environmental Sciences and Ecology

 
14 Science Highlight March 2010 Deadly Carcinogen Unraveled: The Molecular Origami of Fungal Polyketides
 

Summary:  Polyketides Aflatoxin is an unavoidable food contaminant in grains and nuts produced in developing countries... belong to a class of natural products called polyketides, which are biosynthesized in many bacteria... and fungi (1,2). Polyketide natural products produced by bacteria and fungi are often characterized

  

Source: Wechsler, Risa H. - Kavli Institute for Particle Astrophysics and Cosmology, Stanford Linear Accelerator Center

 

Collection: Physics

 
15 Chemistry & Biology, Vol. 11, 3345, January, 2004, 2004 Elsevier Science Ltd. All rights reserved. DOI 10.1016/j.chembiol.2003.12.014 Leinamycin Biosynthesis Revealing Unprecedented
 

Summary:  Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase is mediated... nonribosomal pep- tide synthetase (NRPS), polyketide synthase (PKS), hy- of natural products by genetic... Q and LnmP) and modular (LnmI) NRPS, acyltransferase-less PKS (LnmG, LnmI, product biosynthetic gene

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
16 Abstract A Tn5-1063-derived mutant of Nostoc puncti-forme strain ATCC 29133 was unable to fix N2 in air al-
 

Summary:  . These active sites are characteristic of polyketide and fatty acid synthases. The N. punctiforme strain 29133... glycolipids follows a pathway characteristic of polyketide synthesis and involves similar large, multienzyme... complexes. Key words Fox­ mutant · Heterocyst glycolipid · hglE · Nostoc punctiforme · Polyketide ...

  

Source: Cohen, Michael F. - Department of Biology, Sonoma State University

 

Collection: Biology and Medicine

 
17 Structure, Vol. 11, 147154, February, 2003, 2003 Elsevier Science Ltd. All rights reserved. PII S0969-2126(03)00004-2 Catalysis, Specificity, and ACP Docking Site
 

Summary:  (MAT), the fabD gene Results and Discussionproduct of Streptomyces coelicolor A3(2), participates... mM sodium acetate (pH of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its... .R., and McDaniel, R. (2001). Alteration of the substrate speci- ficity of a modular ...

  

Source: 

 

Collection: Biology and Medicine

 
18 Columbia University Department of Chemistry Colloquia, Fall 2005
 

Summary:  Lecture ­ "Modular Polyketide Synthases: Biochemical and Structural Basis for the (Monday) Programming

  

Source: Lin, Qiao - Department of Mechanical Engineering, Columbia University

 

Collection: Engineering ; Materials Science

 
19 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Feb. 2011, p. 15011507 Vol. 77, No. 4 0099-2240/11/$12.00 doi:10.1128/AEM.01513-10
 

Summary:  . Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases... modular nonribosomal peptide synthetase (NRPS)-polyketide synthase (PKS) pathway for the biosynthesis... Streptomyces coelicolor A3(2) and analysis of its ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
20 Curriculum Vitae, Yi-Qiang (Eric) Cheng October 2011 Page 1 of 9 I. PERSONAL INFORMATION
 

Summary:  cross-talk between modular polyketide synthases and fatty acid synthase. Applied and Environmental... * (2003) Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis... .3) 10. Du, L., Y.-Q. Cheng, G. Ingenhorst, G.-L Tang, Y. Huang and B. Shen* (2003) Hybrid ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine


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21 Research Paper Cloning and characterization of a phosphopantetheinyl transferase
 

Summary:  prepared from ¢ve di¡erent Strepto- myces species. S. coelicolor A3(2) was chosen as a positive control... Biolabs, Beverly, MA, USA), S. albus JA 3453 [48], S. atroolivaceus [47], S. coelicolor A3(2) [55], S... verticillus ATCC15003, the producer of the hybrid peptide^polyketide ...

  

Source: Toney, Michael - Department of Chemistry, University of California, Davis

 

Collection: Chemistry ; Biology and Medicine

 
22 Identification of the Putative Bryostatin Polyketide Synthase Gene Cluster from "Candidatus Endobugula sertula", the Uncultivated Microbial Symbiont of the Marine Bryozoan
 

Summary:  present the putative biosynthetic genes: five modular polyketide synthase (PKS) genes, a discrete... such as the bryostatins are synthesized by modular polyketide synthases (PKS). Modular PKSs are typically only found... . The bry cluster in deep and shallow "E. sertula". ...

  

Source: Haygood, Margo G. - Division of Environmental and Biomolecular Systems, Oregon Health and Science University

 

Collection: Biotechnology ; Environmental Sciences and Ecology

 
23 Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
 

Summary:  in the resultant polyketide products (2, 3). This one-to-one correspondence between the modularity of enzyme... Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis Yi... , and approved January 10, 2003 (received for review December 2, 2002) Type I ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
24 Gene 237 (1999) 403411 www.elsevier.com/locate/gene
 

Summary:  in the modular polyketide It is, in fact, common for antibiotic-producing organisms synthase. Gene 169, 9... similarity to acyl- CoA dehydrogenases and polyketide synthases, respectively. Insertional inactivation... ; Acyltransferases; Polyketide synthases; Self-resistance 1. Introduction tion nor RNA ...

  

Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
25 Dissection of Malonyl-Coenzyme A Decarboxylation from Polyketide Formation in the Reaction Mechanism of a Plant Polyketide Synthase
 

Summary:  Dissection of Malonyl-Coenzyme A Decarboxylation from Polyketide Formation in the Reaction... Mechanism of a Plant Polyketide Synthase Joseph M. Jez, Jean-Luc Ferrer, Marianne E. Bowman, Richard A... in polyketide formation and elucidate the importance of His303 and Asn336 in the malonyl-CoA decarboxylation

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
26 Copyright 2005 by the American Society for Biochemistry and Molecular Biology, Inc. This article is available online at http://www.jlr.org Journal of Lipid Research Volume 46, 2005 839
 

Summary:  · sphingolipids · sterol lipids · prenol lipids · saccharolipids · polyketides The goal of collecting data... , polyketides, etc.) and/or by carbocation-based condensa- tions of isoprene units (prenols, sterols, etc... as polyketides, acylglycerols, sphingolip- ids, prenols, or saccharolipids. However, for historical

  

Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
27 Natural insights for chemical biologists Christopher T Walsh
 

Summary:  . Starting with the sequence of the erythro- mycin gene cluster2,3, the rules for modular assembly of malonyl... - and methylmalonyl-CoA monomers into thousands of structural vari- ants of polyketides have been delineated4... and matches assembly-line elements, and the underlying chemistry for making polyketide­nonribosomal ...

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
28 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jan. 2004, p. 104113 Vol. 70, No. 1 0099-2240/04/$08.00 0 DOI: 10.1128/AEM.70.1.104113.2004
 

Summary:  myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide... similarity to genes involved in peptide and polyketide antibiotic biosynthesis. The mutant that overproduced... intermediates. Additionally, nonribosomal peptide synthetase (NRPS) and polyketide ...

  

Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
29 The Iromycins, a New Family of Pyridone Metabolites from Streptomyces sp. I. Structure, NOS Inhibitory Activity, and
 

Summary:  propionate units, presumably condensed by a type I modular polyketide synthase. In contrast, 3 and 4... -labeled precursors indicated an uncommon type of polyketide biosynthesis and clearly ruled out... observation and here we demonstrate it with the iromycin family. Introduction Polyketides are ...

  

Source: Müller, Peter - Department of Chemistry, Massachusetts Institute of Technology (MIT)

 

Collection: Chemistry

 
30 Z .Comparative Biochemistry and Physiology Part B 128 2001 445 450 Purification and characterization of the fatty acid
 

Summary:  . Rev. 97, 2525 2535. Katz, L., 1997. Manipulation of modular polyketide synthases. Chem. Rev. 97, 2557... .acid synthases and polyketide synthases PKS Z .Smith, 1994 , and the greater relative abundance... entry into the enzymology of this bryozoan. PKSs from bacteria consist of either a Z .modular type I

  

Source: Kerr, Russell G. - Department of Chemistry and Biochemistry, Florida Atlantic University

 

Collection: Biology and Medicine ; Chemistry

 
31 Chemistry & Biology Genome-Wide High-Throughput Mining
 

Summary:  design and rearrange- ment of modular polyketide synthase genes. Nat. Biotechnol. 23, 1171­1176. 12... encoding the natural-product biosynthetic enzymes, polyketide synthases (PKSs) and non- ribosomal peptide... , that inhabit virtually every niche of the biosphere. Among them, polyketide synthase (PKS) and ...

  

Source: Yin, Jun - Department of Chemistry, University of Chicago

 

Collection: Chemistry

 
32 Vol 436|18 August 2005 RESEARCH HIGHLIGHTS
 

Summary:  .1038/nbt1128 (2005) Escherichia coli bacteria have been engineered to make novel polyketides -- molecules... that can kill bacteria and inhibit cancer cells -- using a modular approach. Typically, soil microorganisms... make polyketides using hefty enzymes encoded in genetic sequences up to 50,000 bases long. To make

  

Source: Hamilton, Douglas P. - Department of Astronomy, University of Maryland at College Park

 

Collection: Physics

 
33 Alexeev, I., A. Sultana, P. Mantsala, J. Niemi, and G. Schneider. 2007. Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site. Proc. Natl. Acad. Sci. U.
 

Summary:  coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues and has a preference... . 2002. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417... and developmental biology of its host, Streptomyces coelicolor ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
34 EVOLUTION OF PROTEIN FUNCTION BY DOMAIN SWAPPING
 

Summary:  in modular proteins (McLachlan, 1987). The two possible evolutionary outcomes for such duplications... that chymotrypsin evolved by tandem duplication, although no detectable sequence similarity remains. 3. Modular... Proteins Modular proteins are described as displaying a beads-on-a-string orga- nization of domains

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
35 Mechanism of Chalcone Synthase pKa OF THE CATALYTIC CYSTEINE AND THE ROLE OF THE CONSERVED HISTIDINE IN A PLANT
 

Summary:  HISTIDINE IN A PLANT POLYKETIDE SYNTHASE* Received for publication, September 19, 2000 Published, JBC Papers... Polyketide synthases (PKS) assemble structurally di- verse natural products using a common mechanistic... strategy that relies on a cysteine residue to anchor the polyketide during a series of decarboxylative

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
36 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Aug. 2004, p. 49214929 Vol. 70, No. 8 0099-2240/04/$08.00 0 DOI: 10.1128/AEM.70.8.49214929.2004
 

Summary:  esters from PKC by bryostatin (32). Macrolide polyketides like bryostatins are produced by type I modular... of the bryostatins, polyketides that provide chemical defense to the host and are also being tested for use in human... polyketide synthase (PKS) primers amplified a gene fragment from B. simplex that ...

  

Source: Haygood, Margo G. - Division of Environmental and Biomolecular Systems, Oregon Health and Science University

 

Collection: Biotechnology ; Environmental Sciences and Ecology

 
37 Evidence for Catalytic CysteineHistidine Dyad in Chalcone Synthase
 

Summary:  ) A chain initiation factor common to both modular and aromatic polyketide synthases. Nature 401, 502­ 505... synthase (STS, EC 2.3.1.95) are multifunctional plant polyketide synthases (PKS) (1). The amino acid se... pyrocarbonate; Idm, iodoacetamide; KS, 3-ketoacyl-(acyl carrier protein) synthase; PKS, ...

  

Source: Suh, Dae-Yeon - Department of Chemistry and Biochemistry, University of Regina

 

Collection: Chemistry

 
38 Elucidating the Substrate Specificity and Condensation Domain Activity of FkbP, the FK520 Pipecolate-Incorporating Enzyme
 

Summary:  polyketide synthase (PKS)/nonribosomal peptide synthetase (NRPS) systems in streptomycetes. An important... polyketide chain by the action of RapP/FkbP, a four-domain NRPS that also putatively serves to cyclize... of two related enzyme families: nonribosomal peptide synthetases (NRPSs)1 and polyketide synthases (PKSs

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
39 Research Paper Analysis of the prodiginine biosynthesis gene cluster of
 

Summary:  Research Paper Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2... reserved. Keywords: Antibiotic; Fatty acid synthase; Modular polyketide synthase; Non-ribosomal peptide... by Streptomyces coelicolor A3(2) was ¢rst discovered ...

  

Source: Bibb, Mervyn - Department of Molecular Microbiology, John Innes Centre

 

Collection: Biology and Medicine

 
40 Bacillus subtilispathway ofpksXproteins in the -carrierSConvergence of isoprene and polyketide biosynthetic machinery: Isoprenyl-
 

Summary:  Bacillus subtilispathway ofpksXproteins in the -carrierSConvergence of isoprene and polyketide... of isoprene and polyketide biosynthetic machinery: Isoprenyl-S-carrier proteins in the pksX pathway... is predicted to encode the biosynthesis of an as yet uncharacterized hybrid nonribosomal pep- tide polyketide

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine


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41 Although acetaminophen (para-cetamol) has been used clinically
 

Summary:  Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes... products by altering or replacing individual polyketide synthase (PKS) gene modules is laborious and time... -consuming. Menzella et al. present a combinatorial method for producing ...

  

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
42 Introduction Chapter one
 

Summary:  modification of thiolation domains of peptide synthetases, modular fatty acid synthases and polyketide... with the polyketide synthetases, are the largest proteins present in the cell. Genetic and biochemical analyses... of many peptide synthetases have revealed that these multifunctional proteins exhibit a ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
43 Molecular Microbiology (2000) 37(5), 989994 MicroOpinion
 

Summary:  in microorganisms comes from a study of polyketide synthases (PKS) (Hutchinson, 1999; Shen et al., 1999... ). This tolerance not only allows each unit of the modular pathway to accept a wide range of substrates, but it also... of the . 3000 polyketides known in nature, but also provides a rational basis for further attempts to ...

  

Source: Jones, Clive G. - Cary Institute of Ecosystem Studies

 

Collection: Environmental Sciences and Ecology

 
44 DOI: 10.1126/science.1155313 , 239 (2008);320Science
 

Summary:  in cultured rat car- diomyocytes. (A) Modular organization of Lmod and constructsusedinthisstudy (TM-h1, TM-h2... ; accepted 19 February 2008 10.1126/science.1155313 Deconstruction of Iterative Multidomain Polyketide... aflatoxin B1, is one of the multidomain iterative polyketide synthases (IPKSs), a large, poorly understood

  

Source: Pollard, Thomas D.- Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Biology and Medicine

 
45 HARNESSING PLANT BIOMASS FOR BIOFUELS AND BIOMATERIALS Nature's assembly line: biosynthesis of simple
 

Summary:  of simple phenylpropanoids and polyketides Oliver Yu* and Joseph M. Jez Donald Danforth Plant Science Center... and absolute quantity of these compounds. The phenylpropanoids, and the related plant polyketides, have... -groups of these polyphenolic compounds ­ polyketides, stilbenes, isoflavones and catechins. We discuss the ...

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
46 SSB pushed off free DNA end
 

Summary:  21 October 1909. BIOCHEMISTRY Enzyme'sblackboxcrackedopen David H. Sherman Polyketide synthase... of the enzymes' ability to use such unstable precursors has been laid bare. Polyketides form a structurally... -lowering drug lovastatin. But it's not all good news. Some polyketides are dangerous, such as aflatoxin B1

  

Source: Cistola, David P. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis; Lohman, Timothy M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
47 he primary goal of protein engineering is to cre-ate a novel protein Y that possesses some improved
 

Summary:  peptides30, polyketides31 and terpenes32, have also been amenable to hybrid-enzyme manipulation, owing... to their modular nature. Nonribosomal synthe- sis of peptide secondary metabolites is catalysed by multifunctional... amino acid substitutions. Polyketides are a group of secondary metabolites constructed through

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
48 Thioesterase Portability and Peptidyl Carrier Protein Swapping in Yersiniabactin Synthetase from Yersinia pestis
 

Summary:  , including polyketide synthases (PKSs), nonribosomal peptide syn- thetases (NRPSs), and mixed PKS... proteins and lessons for protein engineering in generating novel modular enzymes were discussed. Yersinia... to convert salicylate, three cysteines, and malonyl-CoA into the mixed nonribosomal peptide/polyketide Ybt

  

Source: Suo, Zucai - Department of Biochemistry, Ohio State University

 

Collection: Biology and Medicine

 
49 JOURNAL OF BACTERIOLOGY, Dec. 2002, p. 70137024 Vol. 184, No. 24 0021-9193/02/$04.00 0 DOI: 10.1128/JB.184.24.70137024.2002
 

Summary:  of the model actino- mycete Streptomyces coelicolor A3(2). Nature 417:141­147. 3. Bierman, M., R. Logan, K. O... -containing hybrid peptide- polyketide natural product structurally characterized with an unprecedented 1,3-dioxo-1... I is characterized by domains characteristic to both NRPS and polyketide ...

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
50 Nostoc punctiforme is a filamentous cyanobacterium capable of forming symbiotic
 

Summary:  and polyketide synthases. We intend to test the functionality of these clusters and a possible involvement... ., Hinrichs, K., Stangeland, J., Hertweck, C., Dittmann, E. (2011) A polyketide interfers with cellular

  

Source: Potsdam, Universität - Institut für Physik, Arbeitsgruppe Nichtlineare Dynamik

 

Collection: Physics

 
51 Cyanobacteria are known as a prolific source of secondary metabolites exhibiting unique
 

Summary:  ) Evolution of metabolic diversity: Insights from microbial polyketide synthases. Phytochem. 70... ., Hertweck, C., Piel, J. (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases... -Kodama, H., He, J., Dittmann, E., Hertweck, C. (2007) Non-Colinear Polyketide Biosynthesis in the Aureothin

  

Source: Potsdam, Universität - Institut für Physik, Arbeitsgruppe Nichtlineare Dynamik

 

Collection: Physics

 
52 Molecular Biotechnology LaboratoryMolecular Biotechnology Laboratory (Prof. Nancy Da Silva)(Prof. Nancy Da Silva)
 

Summary:  of PolyketidesMetabolic Engineering of Yeast for the Synthesis of Polyketides Synthesis of CellSynthesis of Cell

  

Source: George, Steven C. - Department of Biomedical Engineering, University of California, Irvine

 

Collection: Biology and Medicine

 
53 Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
 

Summary:  Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery... . Enzyme Machinery 3474 3.1. Polyketide Synthase Enzymatic Machinery: Canonical Organization 3474 3... molecule natural products with interesting biological activities are polyketides (PK), non- ribosomal

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
54 Excision of the Epothilone Synthetase B Cyclization Domain and Demonstration of in Trans Condensation/Cyclodehydration Activity
 

Summary:  anticancer natural products produced by a polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS... for introduction of the thiazoline heterocycle into the growing polyketide/nonribosomal peptide chain from... (NRPSs)1 and polyketide synthases (PKSs) are large, multimodular enzymes respon- sible

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
55 SMURF: Genomic mapping of fungal secondary metabolite clusters Nora Khaldi a
 

Summary:  Keywords: NRPS PKS Prenyltransferases Polyketides Antibiotics Secondary metabolism Filamentous fungi... refer to here as ``backbone" en- zymes. They include nonribosomal peptide synthases (NRPSs), polyketide... : nonribosomal peptides, polyketides, NRPS­PKS hybrids, indole alkaloids, and terpenes (Hoffmeister and Keller

  

Source: Wolfe, Kenneth H. - Genetics Department, Trinity College, University of Dublin

 

Collection: Biotechnology ; Environmental Sciences and Ecology

 
56 General introduction Submitted for publication together with chapter 5
 

Summary:  coelicolor A3(2) has consolidated as the model organism within the streptomycetes (Chater, 2006... prototrophic derivative of A3(2) lacking the two S. coelicolor plasmids SCP1 and SCP2) has been published... (Hesketh et al., 2007). There are many more A3(2) derived ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
57 Mycosubtilin operon Chapter two
 

Summary:  synthetases have revealed a modular structure of these multifunctional proteins (Ullrich et al.,1991; Scott... - configuration to the D-configuration (De Crécy-Lagard et al., 1995; Stein et al., 1995). The conserved modular... synthetase genes revealed a typical modular structure, and indicated that the isolated DNA fragment ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
58 group from The Institute for Genomic Research (Ravel and Eisen), and in the course of our studies we rationally
 

Summary:  -producing actinomycetes. Patent WO2004013297 7 Hildebrand, M. et al. (2004) bryA: an unusual modular polyketide synthase... . (2004) Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes... , 1543­1552 8 Piel, J. et al. (2004) Antitumor ...

  

Source: Ziegler, Kirk J. - Chemical Engineering Department, University of Florida

 

Collection: Materials Science

 
59 10.1021/ol103117j r 2011 American Chemical Society Published on Web 02/16/2011
 

Summary:  , 2011 ABSTRACT A potentially biomimetic approach toward the complex polyketide A-74528 is described... polyketides known to date. Interestingly, the biosynthetic machinery responsible for its formation is very... similar to the type II polyketide synthase that accounts for the formation of fredericamycin (2

  

Source: Trauner, Dirk - Department Chemie, Ludwig Maximilians Universität München

 

Collection: Chemistry

 
60 TRENDS in Biochemical Sciences Vol.27 No.9 September 2002 http://tibs.trends.com 0968-0004/02/$ see front matter 2002 Elsevier Science Ltd. All rights reserved. PII: S0968-0004(02)02168-0
 

Summary:  chain initiation factor common to both modular and aromatic polyketide synthases. Nature 401, 502­505 45... of docosahexaenoic acid (22:6) in mammals and a polyketide synthase pathway in marine microbes. Published online: 15... , and instead uses a polyketide synthase to produce 20:5n3 and 22:6n3 [15]. ...

  

Source: Watts, Jennifer - School of Molecular Biosciences, Washington State University

 

Collection: Biology and Medicine


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61 RESEARCH ARTICLES DothideomycetePlant Interactions Illuminated by Genome
 

Summary:  of expression. Polyketide synthases (PKSs) are a second modular gene family strongly associated... ,762 nuclear genes. Extensive orthology was found between the polyketide synthase family in S. nodorum... libraries. Nonribosomal peptide synthetases (NRPSs) are modular en- zymes that synthesize a diverse set

  

Source: McDonald, Bruce - Institut für Integrative Biologie, Eidgenössische Technische Hochschule Zürich (ETHZ)

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
62 Probing Intra-versus Interchain Kinetic Preferences of L-Thr Acylation on Dimeric VibF with Mass Spectrometry
 

Summary:  nonribosomal peptide synthetases, and to the related fatty acid and polyketide synthases, will further our... ), and polyketide synthases (PKSs), and much effort has been placed on understanding the mechanisms... of polyketide synthases and nonribosomal peptide synthe- tases. Chem. Biol. 6:R319­R325. 2. Cane, D. E., C. T

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
63 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, June 2007, p. 34603469 Vol. 73, No. 11 0099-2240/07/$08.00 0 doi:10.1128/AEM.01751-06
 

Summary:  . 968 genomic DNA clones that code for portions of nonribosomal peptide synthetase and polyketide... synthetase-polyketide synthase-nonribosomal peptide synthetase assembly line includ- ing accessory activities... derived from malonyl coenzyme A (MCoA). These observations suggest a hybrid nonribosomal peptide (NRP)-polyketide

  

Source: Cheng, Yi-Qiang "Eric" - Department of Biological Sciences, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
64 Nonribosomal peptide synthesis in Bacillus subtilis
 

Summary:  modification of thiolation domains of peptide synthetases, modular fatty acid synthases and polyketide... with the polyketide synthetases, are the largest proteins present in the cell. Genetic and biochemical analyses... of many peptide synthetases have revealed that these multifunctional proteins exhibit a ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
65 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 0099-2240/01/$04.00 0 DOI: 10.1128/AEM.67.10.45314537.2001
 

Summary:  metabolites synthesized by modular type I polyketide synthases (PKS-I). PKS-I gene fragments were cloned from... is the most likely source of bryostatins. Bryostatins are complex polyketides similar to bacterial secondary... . neritina is the sole source of this unique family of macrolides. The bryostatins are complex ...

  

Source: Haygood, Margo G. - Division of Environmental and Biomolecular Systems, Oregon Health and Science University

 

Collection: Biotechnology ; Environmental Sciences and Ecology

 
66 Regulation of secondary metabolism in streptomycetes Mervyn J Bibb
 

Summary:  polyketide biosynthetic cluster of Streptomyces coelicolor A3(2). Mol Microbiol 2005: in press. Comprehensive... coelicolor A3(2): new mechanisms for chain initiation and termination in modular multi-enzymes. Chem Biol... for antibiotic production under conditions of ...

  

Source: Bibb, Mervyn - Department of Molecular Microbiology, John Innes Centre

 

Collection: Biology and Medicine

 
67 Chemoenzymatic Approaches for Streamlined Detection of Active Site Modifications on Thiotemplate Assembly Lines Using Mass Spectrometry
 

Summary:  scaffolds known as nonribosomal peptide synthetases (NRPSs)1 and polyketide synthases (PKSs) (1... pharmaceuticals is accelerating rapidly. The "modular" configuration of NRP/PK synthetases has sparked an interest... of Illinois. § Harvard Medical School. 1 Abbreviations: NRPS, nonribosomal peptide synthetase; PKS, polyketide

  

Source: Yin, Jun - Department of Chemistry, University of Chicago

 

Collection: Chemistry

 
68 The ultimate rendezvous: microbial ecology meets industrial biotechnology
 

Summary:  of polyketides, one of the research areas where the power of generating and shuffling gene libraries was first... shown. This is because these antibiotics are non-ribosomal peptides typically produced by multi- modular

  

Source: Sheridan, Jennifer - Women in Science and Engineering Leadership Institute, University of Wisconsin at Madison

 

Collection: Multidisciplinary Databases and Resources

 
69 Molecular Cell, Vol. 16, 881891, December 22, 2004, Copyright 2004 by Cell Press A Mechanism for the Potent Inhibition of Eukaryotic
 

Summary:  for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme A Carboxylase by Soraphen A, a Macrocyclic Polyketide... ) (Abu-Elheiga et al., 2001; Lenhard and Gottschalk,clic polyketide natural product, is a nanomolar... .,structure-based design of new inhibitors against 1994, 2003). This polyketide natural product contains anthese ...

  

Source: Tong, Liang - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
70 Structural and Functional Analysis of Tetracenomycin F2 Cyclase from Streptomyces glaucescens
 

Summary:  A TYPE II POLYKETIDE CYCLASE* Received for publication, June 2, 2004, and in revised form, June 28, 2004... to be the active site. This type of secondary structural arrangement has been previously observed in polyketide... into the structural framework necessary to per- form the complex rearrangements catalyzed by this class of ...

  

Source: Rayment, Ivan - Department of Biochemistry, University of Wisconsin at Madison

 

Collection: Chemistry ; Biology and Medicine

 
71 Extracting the hierarchical organization of complex systems
 

Summary:  is not locally dense (Fig. 2). We propose a new affinity measure based on the surveying of the modularity... (18, 19), and assign to each partition P P the modularity M P i 1 m li L di 2L 2 , [1] where L... . 1A). The modularity of a partition is high when the number of intramodule links is much larger than

  

Source: Amaral, Luis A.N. - Department of Chemical and Biological Engineering, Northwestern University

 

Collection: Physics ; Biology and Medicine

 
72 De novo Assembly of a 40 Mb Eukaryotic Genome from Short Sequence Reads: Sordaria macrospora, a Model
 

Summary:  . macrospora contains more polyketide biosynthesis genes than N. crassa. Phylogenetic analyses suggest

  

Source: Kück, Ulrich - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
73 Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes
 

Summary:  that function as molecular assembly lines. The modular architecture of NRPSs suggests that a domain responsible... , including one that produces new derivatives of the potent NRP/ polyketide antibiotic andrimid. Because... challenging hosts. nonribosomal peptide polyketide Many small molecules with important biological activities

  

Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University

 

Collection: Chemistry ; Biology and Medicine

 
74 Swaps in Protein Sequences Amit Fliess, Benny Motro, and Ron Unger*
 

Summary:  . This observation is at odds with the common view that proteins are very modular to the point that modules (e... ). The cases of fatty-acid synthases (FAS2_CANAL and FAS_CHICK, Table I, 2.) and polyketide synthases [MSAS... recorded in our study, the swapping fragments were identified as distinct modular domains known

  

Source: Unger, Ron - Faculty of Life Sciences, Bar Ilan University

 

Collection: Biology and Medicine

 
75 RESEARCH Open Access Comparative genomics of the social amoebae
 

Summary:  others, such as the polyketide synthases, have undergone extensive diversification. The abundant amino... . Polyketide synthases Polyketide synthases (PKSs) are enzymatic production lines for making small molecules... of polyketides exist and are probably made for ecological purposes, but they also serve as ...

  

Source: Babu, M. Madan - Laboratory of Molecular Biology, MRC

 

Collection: Biotechnology

 
76 Subscriber access provided by SCRIPPS RSRCH INST ACS Chemical Biology is published by the American Chemical Society. 1155 Sixteenth
 

Summary:  of polyketide synthases (PKS) and nonribosomal peptide synthetase (NRPS) biosynthetic pathways and our... -sites to provide activity-based enrichment of modular synthases, followed by analysis through multidimensional... Bacillus subtilis, this functional proteomics method detects and quantifies all four modular synthases

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
77 The plant phenylpropanoid pathway provides anthocyanins used for pigmentation and protection against UV photodam-
 

Summary:  @sbl.salk.edu Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis Jean-Luc Ferrer1... . It produces chalcone by condensing one p-coumaroyl- and three malonyl- coenzyme A thioesters into a polyketide... the chemical basis of plant polyketide biosynthesis and provides a framework for engineering ...

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
78 Structurally diverse natural products that cause potassium leakage trigger multicellularity in
 

Summary:  formation in LB. After testing a relatively small panel of compounds, we found that the polyene polyketide... ). To decipher how B. subtilis senses nystatin, we attempted to define the properties of this polyene polyketide... is also a polyene polyketide, but it differs from nystatin in its functionality. Filipin does not form

  

Source: Losick, Richard M. - Department of Molecular and Cellular Biology, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
79 RESEARCH ARTICLE Open Access The dynamic architecture of the metabolic
 

Summary:  T, associated with Streptomyces coelicolor A3(2) modular polyketide synthase Cpk, hydrolyzes acyl residues... strain and cultivation conditions Experiments were performed using S. coelicolor A3(2) strain M145 [26... in morphological differentiation and antibiotic ...

  

Source: Breitling, Rainer - Groningen Bioinformatics Centre, Rijksuniversiteit Groningen

 

Collection: Biology and Medicine ; Biotechnology

 
80 1 Copyright 2000 by ASME Proceedings of DETC2000
 

Summary:  element electric automotive vehicle power train modular model equations (32a-32b). Form of the unconnected... matrix T to (32a-32b) to partition the inputs and outputs internally and externally. Apply the internal... (39) has the same input-output topology (Fig. 4) as the linear ...

  

Source: Radcliffe, Clark J. - Department of Mechanical Engineering, Michigan State University

 

Collection: Engineering


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81 Regulation of antibiotic production in Streptomyces coelicolor A bacterial hormone receptor variant and
 

Summary:  coelicolor A3(2) has consolidated as the model organism within the streptomycetes (Chater, 2006... prototrophic derivative of A3(2) lacking the two S. coelicolor plasmids SCP1 and SCP2) has been published... (Hesketh et al., 2007). There are many more A3(2) derived ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
82 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Sept. 2007, p. 55235530 Vol. 73, No. 17 0099-2240/07/$08.00 0 doi:10.1128/AEM.00577-07
 

Summary:  via modular polyketide synthase and nonribosomal peptide synthetase (NRPS) megasynthases, and NRPS... three large polyketide syn- thase (PKS) and nonribosomal peptide synthetase (NRPS) genes. Transposon... is responsible for a discrete stage of polyketide or polypeptide chain elongation (7). Moreover, each ...

  

Source: Mondolot, Laurence - Centre d’Ecologie Fonctionnelle et Evolutive, Université Montpellier I

 

Collection: Biology and Medicine

 
83 INTRODUCTION Synthetic biology: history, challenges
 

Summary:  parts and modular construction methods. Engineers were then free to reap the benefits of abstraction... , resulting in robust pattern formation. The modularity of RNA-based logic gates/switches is also seen... to be robust. Examples include phosphoryl- ation-based signalling cascades, polyketide synthase `assembly lines

  

Source: Haseloff, Jim - Department of Plant Sciences, University of Cambridge

 

Collection: Biology and Medicine

 
84 Department of Chemistry, University of Connecticut, Storrs Fall 2011 Seminar Schedule
 

Summary:  . Kumar Sept. 21 Professor Nate Schnarr Simplified Approaches for Improved Control Over Polyketide

  

Source: Michel, Robert G. - Department of Chemistry, University of Connecticut

 

Collection: Chemistry

 
85 Multiplex Sequencing of 1.5 Mb of the Mycobacterium leprae Genome
 

Summary:  therapeutic and vaccine targets. Unusual features of the M. leprae genome include large polyketide synthase... members of a family of polyketide synthase (pks) genes (including four within a single large operon... , separated by 3.8 kb, are con- tained in two adjacent polyketide synthase genes encoded by the L518 operon

  

Source: Church, George M. - Wyss Institute for Biologically Inspired Engineering & Department of Genetics, Harvard University

 

Collection: Biotechnology

 
86 Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter
 

Summary:  Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter... for review November 4, 2001) Type III polyketide synthases (PKS) generate an array of natural products... of these biosynthetic enzymes involves modifying polyketide assembly by altering the preference for starter molecules

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
87 School of Chemistry 2009 -Highlight Papers
 

Summary:  in the actinorhodin minimal polyketide synthase P. Beltran-Alvarez, C. J. Arthur, R. J. Cox, J. Crosby, M. P. Crump... with other components of the actinorhodin minimal polyketide synthase was examined using steady state kinetic... partners in the polyketide synthase complex. Earliest horse harnessing and milking A.K. Outram, ...

  

Source: Bristol, University of - School of Geographical Sciences, Bristol Glaciology Centre

 

Collection: Environmental Sciences and Ecology ; Geosciences

 
88 Autonomous multistep organic synthesis in a single isothermal solution mediated
 

Summary:  as pathways that generate polyketides and non-ribosomal peptides3,4, this strategy enables the sequence... to a target. Nature Methods 4, 269­279 (2007). 3. Walsh, C. T. Polyketide and nonribosomal peptide antibiotics... : modularity and versatility. Science 303, 1805­1810 (2004). 4. Sattely, E. S., Fischbach, M. A. & ...

  

Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University

 

Collection: Chemistry ; Biology and Medicine

 
89 Structure-Guided Programming of Polyketide Chain-Length Determination in Chalcone Synthase
 

Summary:  Structure-Guided Programming of Polyketide Chain-Length Determination in Chalcone Synthase Joseph M... polyketide synthases (PKS) that catalyze formation of structurally diverse polyketides. CHS synthesizes... that is in direct contact with the polyketide chain derived from malonyl-CoA. Thus, position 256 ...

  

Source: Jez, Joseph - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
90 Appl Microbiol Biotechnol (2004) 65: 473478 DOI 10.1007/s00253-004-1670-y
 

Summary:  contamination in cottonseed has a defective polyketide synthase gene Received: 28 January 2004 / Revised: 4 May... to competitively exclude aflatoxin-producing Aspergillus species. We now show that the polyketide synthase gene... two fatty acid synthases and a polyketide synthase necessary for the first steps in aflatoxin

  

Source: Cotty, Peter J. - School of Plant Sciences, University of Arizona

 

Collection: Biology and Medicine

 
91 Genome sequence of the pattern forming Paenibacillus vortex bacterium reveals potential
 

Summary:  as building blocks of colonies with special modular organization (Figure 1 and Additional file 1 section I... ] are underpinned by a highly developed signal trans- duction system consisting of modular domains forming a network... purposes in the pharmaceutical industry. The PKS genes for a certain polyketide are usually organized

  

Source: Jacob, Eshel Ben - School of Physics and Astronomy, Tel Aviv University

 

Collection: Physics

 
92 A truer measure of our ignorance Luis A. Nunes Amaral*
 

Summary:  for networks with no internal structure (11). Work by numerous re- searchers on the detection of modular... acids Secondary metabolites Glycans Polyketides and nonribosomal peptides Cofactors and vitamins pep coa

  

Source: Amaral, Luis A.N. - Department of Chemical and Biological Engineering, Northwestern University

 

Collection: Physics ; Biology and Medicine

 
93 Chemistry & Biology, Vol. 11, January, 2004, 2004 Elsevier Science Ltd. All rights reserved. DOI 10.1016/j.chembiol.2004.01.004 mountable competitive advantage over 10-23 and otherBreaking Up Is Easy To Do
 

Summary:  on these data, Cruz In this issue of Chemistry & Biology, Cruz et al. use in et al. offer a modular structural... -vomycin, UCH9, and durhamycin A, are a family of aro- matic polyketides that share an identical tricyclic core

  

Source: Silverman, Scott K. - Department of Chemistry, University of Illinois at Urbana-Champaign

 

Collection: Chemistry ; Biology and Medicine

 
94 Mutational Analysis of Conserved Outer Sphere Arginine Residues of Chalcone Synthase
 

Summary:  , outer sphere mutation, stilbene synthase, type III polyketide synthase, site-directed mutagenesis... ; PCS, pentaketide chromone synthase; PGO, phenylglyoxal; PKS, polyketide synthase; STS, stilbene... flavonoids (Fig. 1). CHS and homologous members of the CHS superfamily, also known as type III polyketide

  

Source: Suh, Dae-Yeon - Department of Chemistry and Biochemistry, University of Regina

 

Collection: Chemistry

 
95 The circuit-like connectivity of biological parts and their ability to collectively process logical operations
 

Summary:  of modularization, rationalization and modelling, has progressed rapidly and generated an ever-increasing suite... ). The two basic sensing modules must be delicately balanced: this is achieved by programming modularity... Modularity The capacity of a system or component to function independently of context. Environment

  

Source: Collins, James J. - Wyss Institute for Biologically Inspired Engineering & Department of Biomedical Engineering, Boston University

 

Collection: Engineering ; Biotechnology

 
96 1. Abrhamova Z, Patek M & Nesvera J (2002) Atypical location of double-strand origin of replication (nic site) on the plasmid pGA1 from Corynebacterium
 

Summary:  of the model actinomycete Streptomyces coelicolor A3(2). Nature 417: 141-147. #12;References 98 10. Benveniste... of a second sex factor, SCP2, for Streptomyces coelicolor A3(2). Mol Gen Genet 154: 155-166. 14. Bibb MJ, Ward... sequence. Nature 393: 537-544. 31. Davis NK & Chater KF (1990) Spore colour ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
97 Modulhandbuch Bachelor-Studiengang Biochemie Organische Chemie 1
 

Summary:  , Nukleinsäuren, Terpene, Polyketide. Die oben aufgeführten Inhalte, speziell die Stoffgruppen und Konzepte

  

Source: Manstein, Dietmar J. - Department of Biophysical Chemistry, Medizinische Hochschule Hannover

 

Collection: Biology and Medicine

 
98 CHEMISTRY 622 BIOSYNTHESIS OF PLANT NATURAL PRODUCTS
 

Summary:  : shikimate, acetogenin (otherwise known as the polyketide) and terpenoid pathways. Alkaloids, while often... Chapter 5 The polyketide pathway 13-Oct 15-Oct 18-Oct Examples of biosynthetic studies involving... polyketides from the literature 20-Oct 22-Oct 25-Oct chapter 5 mixed pathways- the flavanoids 27-Oct oxidative

  

Source: Wagner, Diane - Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks

 

Collection: Environmental Sciences and Ecology

 
99 Genetically Encoded Short Peptide Tags for Orthogonal Protein Labeling by Sfp and AcpS
 

Summary:  alone as key parts of the biosynthetic machinery of nonribosomal peptide synthetases (NRPSs), polyketide... successive anchoring points for the attachment of the growing peptide, polyketide, or fatty acyl chains... - ence 282, 63­68. 4. Marahiel, M. A., Stachelhaus, T., and Mootz, H. D. (1997) Modular peptide

  

Source: Yin, Jun - Department of Chemistry, University of Chicago

 

Collection: Chemistry

 
100 R E V I E W A R T I C L E The complexextracellular biologyof Streptomyces
 

Summary:  of an antibiotic (streptomycin) (Horinouchi, 2007) and Streptomyces coelicolor A3(2), the most widely used... - duced family 18 chitinases and two family 19 chitinases, with various modular arrangements comprising

  

Source: Palmer, Tracy - Division of Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine


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