| Sample search results for: a1 receptor agonist |
| 1 | The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays | ||
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Summary: modelling and virtual screening assays Michael Schneider a,1 , Steffen Wolf a,b , Jürgen Schlitter a , Klaus... and inverse agonists in structure-based computational ligand screening. Using the b2- adrenergic receptor (B2... AR) [1618], the agonist-bound b1-adrenergic ... |
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Source: Gerwert, Klaus - Fakultät für Biologie, Ruhr-Universität Bochum |
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Collection: Biology and Medicine |
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| 2 | Special issue: Allosterism and Collateral Efficacy Conformational complexity of | ||
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Summary: histamine receptor [20], the a1b adrenoceptor [21,22] and the angiotensin (AT1) receptor [23]. My co... Scheer, A. et al. (1997) The activation process of the a1B-adrenergic receptor: potential role... protein in the absence of an ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 3 | Copyright C Blackwell Munksgaard 2002 Traffic 2002; 3: 866877 | ||
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Summary: expressing HA-tagged receptors were treated with agonist (C5a 1mM, 30min) or left untreated. Cells were fixed... that is activated only upon exposure to agonist; this revertant receptor (NQ/N296A) is nevertheless consti- tutively... other ... |
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Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco |
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Collection: Biology and Medicine |
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| 4 | Serotonin is a biogenic amine that activates a large and heterogeneous family of receptors that are widely | ||
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Summary: that the binding of at least three agonist molecules is required to open the channel. 3. Homomeric 5-HT3A receptors... of the channel by agonist. 7. Simultaneously fitting the macroscopic 5-HT3A receptor responses in patches... that homomeric 5-HT3A receptors require the binding of three ... |
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Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 5 | Binding, gating, anity and ecacy The nature of the problem | ||
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Summary: for an ion channel as b1 and the shutting rate constant as a1, so E1=b1/a1. A mutant receptor in which both b... nicotinic acetylcholine receptor Eect of dierent agonists ont he frog endplate receptor Mutant nicotinic... of ... |
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Source: Colquhoun, David - Department of Pharmacology, University College London |
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Collection: Biology and Medicine |
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| 6 | Stimulating electrode AMPA receptor | ||
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Summary: receptor: Agonist = N-methyl-D-Aspartate Agonist = AMPA GluGABA Cl- GABAA Interneuron GABAB GABA A receptor... GABAB receptor Agonist = baclofen Antagonist = phaclofen Antagonist = 2-amino-5-phosphonovaleric acid... (AP5 or APV) Antagonist = ... |
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Source: Hasselmo, Michael - Department of Psychology & Computational Neurophysiology Laboratory, Boston University |
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Collection: Biology and Medicine |
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| 7 | Function and structure in glycine receptors and some of their relatives | ||
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Summary: of the rat recombinant a1 homomeric glycine receptor as a function of the number of agonist molecules bound... to nicotinic receptors, observations on glycine homomeric a1 receptors [29,30] cannot be fitted well... -channel ... |
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Source: Colquhoun, David - Department of Pharmacology, University College London |
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Collection: Biology and Medicine |
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| 8 | This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the | ||
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Summary: Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... transmembrane domain (see Figure 1(a)). P1 receptors couple principally to adenylate cy- clase. A1 and A3... for both affinity and activity. The most selective ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 9 | Constitutive Activity of a Chimeric D2/D1 Dopamine Receptor LAURA B. KOZELL and KIM A. NEVE | ||
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Summary: intermediate between those of the parent receptors. D2[1 4,7] and D2[15,7] mediated dopamine receptor agonist... in the presence of GTP, and blunted agonist-stimulated cAMP accumulation. A number of dopamine receptor... also inverse agonists at the D1 ... |
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Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University |
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Collection: Biology and Medicine |
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| 10 | Research Article Northern Ring Conformation of Methanocarba-Adenosine | ||
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Summary: produces agonists with widely differing activities at P2Y receptors (Kim et al. [2002] J Med Chem 45... of agonist activity. On nodose ganglion neurones, that express mainly P2X2/3 receptors, ATP evoked a slowly... X receptors. Furthermore, the region of the agonist ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 11 | No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system after chronic A1 receptor | ||
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Summary: of the adenosine A1 receptor agonist N6 -cyclopentyladenosine (CPA) not only desensitizes the adenosine receptors... .c.) injections of the potent and specific A1 receptor agonist N 6 -cyclopentyladenosine ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 12 | Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors | ||
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Summary: of the electrophysiological ac- tions of the more selective mGlu receptor agonists are mentioned briefly. This discussion... ), respectively. A brief overview of only the various agonists and antagonists of mGlu receptor subtypes that have... III, and acts as an agonist at NMDA ... |
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Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 13 | The American Journal of Physiology, Renal Physiology --Manuscript F-00256-2007 -- | ||
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Summary: to A1-adenosine receptor (A1AR) -agonist cyclohexyl-adenosine (CHA). Time course of the response... mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in ... |
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Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg |
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Collection: Biology and Medicine |
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| 14 | Cys-loop receptors: new twists and turns | ||
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Summary: been observed as a result of M2M3 linker region mutations in glycine receptors [4345], nicotinic a1... of naturally occurring pathological mutations in the M2M3 linker region of the glycine receptor a1 subunit [43... ,44] and the nicotinic ACh ... |
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Source: Lester, Henry - Division of Biology, California Institute of Technology |
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Collection: Biology and Medicine |
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| 15 | Allosteric Modulation of 2-Adrenergic Receptor by Zn2 GAYATHRI SWAMINATH, JACQUELINE STEENHUIS, BRIAN KOBILKA, and TAE WEON LEE | ||
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Summary: , allosteric com- pounds have been identified for the A1 adenosine receptor. The 2-amino-3-benzoylthiophene PD... ) The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochim... 258:39133919. Musser B, Mudumbi RV, Liu ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 16 | Regulation of Adenylyl Cyclase Isozymes on Acute and Chronic Activation of Inhibitory Receptors | ||
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Summary: (1987) Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system... above, on chronic treatment with agonists of several different inhibitory receptors, yet under similar... receptor), followed by agonist ... |
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Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science |
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Collection: Biology and Medicine |
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| 17 | Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents | ||
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Summary: by agonists, and accumulation of radiometabolites. We used CB1 receptor knockout mice and P-gp knockout mice... of agonists suggests either a large receptor reserve or non-overlapping binding sites for agonists and inverse... ., 2007). For example, rimonabant, a CB1 ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 18 | Modeling the Binding and Function of Metabotropic Glutamate Xavier Rovira, David Roche, Juan Serra, Julie Kniazeff, Jean-Philippe Pin, and Jess | ||
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Summary: of these dimeric receptors, a negative cooperativity between agonists binding sites was found (Suzuki et al., 2004... depending on the equilibrium constants included in the mechanism (see Equation A1 in the Appendix... according to the VFT binding model represented in Figure 1. As shown in the Appendix ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 19 | JournalofPhysiologyPhysiologyinPress Acetylcholine (ACh) is the major endogenous ligand for | ||
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Summary: ) and nicotine at the rat a4b2 neuronal nicotinic receptor stably expressed in HEK cells. For both agonists... Hillequationprovidingasingle estimate for the EC50 and Hill coefficient. I(x) = A/(1 + (EC50/x)h ), (1) where I is the mean... exponentials: FR(t) = A(1 _ ... |
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Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 20 | NPY signaling through Y1 receptors modulates thalamic oscillations | ||
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Summary: ). Effects of the Y1 receptor agonist Leu31Pro34NPY (A1 and A2), the Y2 receptor agonist PYY336 (B1 and B2... ) and the Y5 receptor agonist BWX-46 (C1 and C2). A1, B1 and C1: Contour ... |
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Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University |
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Collection: Biology and Medicine |
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| 21 | The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have | ||
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Summary: -adrenergic receptor.Structure16, 897905 (2008). 24. Warne, T.etal.Structure of a1-adrenergic G... , inset): full agonists are capable of maximal receptor stimula- tion; partial agonists are unable... 2A1 AR 2 AR 2 AR 2 AR90° ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 22 | Identification of an Allosteric Binding Site for Zn2 Adrenergic Receptor* | ||
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Summary: have been identified for the A1 adenosine receptor. The 2-ami- no-3-benzoylthiophene, PD 81,723, has... muscarinic receptor (19), the A1 adenosine receptor (3), and the Ca2 -sensitive receptor (11). Binding... ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 23 | The Effect of pH on 2 Adrenoceptor Function EVIDENCE FOR PROTONATION-DEPENDENT ACTIVATION* | ||
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Summary: activation for the 2 adrenergic receptor ( 2AR). The rate of agonist-induced change in the fluorescence... on the kinetics of the agonist-induced change in fluorescence, 2550 pmol of IANBD-labeled 2 receptor were diluted... greater loss of binding activity in receptor incubated at pH ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 24 | General Pharmacology 32 (1999) 669681 Serotonin induces four pharmacologically separable contractile | ||
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Summary: of solutions. (A) 1 mM 8-OH-DPAT; (B) 1 mM mCPP; (C) 1 mM DOI; (D) 100 M -Me- 2.2.8. 5-MeOT (5-HT4 agonist) 5... of a large number of selective sero- 5-HT2, 5-HT5, 5-HT6, and 5-HT7 receptors existed before tonin agonists... a number of selective serotonin agonists, ... |
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Source: O'Gara, Bruce A. - Department of Biological Sciences, Humboldt State University |
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Collection: Biology and Medicine |
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| 25 | J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0 | ||
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Summary: accumbens (Diaz-Cabiale et al., 2001). In higher doses CGS 21680 but not an A1 receptor agonist could antag... receptor (see Marshall, 2005). Also the A1R= P2Y1R heteromerization leads to the appearance of an ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 26 | The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have | ||
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Summary: , inset): full agonists are capable of maximal receptor stimula- tion; partial agonists are unable... 28 containing the covalently bound inverse agonist 11-cis retinal. The superpositions of different receptors... Publishers Limited. All rights reserved #12;Rhodopsin Adenosine ... |
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Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 27 | Introduction Chapter 1 1 Introduction | ||
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Summary: to describe the activation of GPCRs by means of a ternary complex formed by a receptor, an agonist, and a G... was confirmed by the use of sumatriptan, at that time known as a selective 5-HT1-like receptor agonist91... receptor antagonist was unable to attenuate serotonin ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 28 | Biochem. J. (2006) 396, 193200 (Printed in Great Britain) doi:10.1042/BJ20051772 193 Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via | ||
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Summary: adenosine A1 receptors preferentially activated PI3K (phospho- inositide 3-kinase) and ILK (integrin... somatostatin sstr3 receptors, Gi2-coupled - opioid receptors, and Gi3-coupled adenosine A1 receptors cause... and ... |
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Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University |
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Collection: Biology and Medicine |
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| 29 | Critical ReviewsTM in Neurobiology, 16(3)187224 [2004] 0892-0915/04 $20.00 2004 by Begell House, Inc. 187 | ||
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Summary: of glutamate receptor ion channels,with an emphasis on the functional and structural aspects of how agonist... receptors in that it requires the binding of both glutamate and the co-agonist glycine to the receptor... ;GLUTAMATE RECEPTOR GATING Volume 16, Number 3, ... |
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Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 30 | Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors | ||
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Summary: receptor inhibition, or direct stimulation with ETB-specific agonists. It appears that the contribution... stimulated by injection of the selective ETB-receptor agonist S6C (10 l 0.5 M) or IRL-1620 (10 l 0.5 M). Time... was that ET and ET-receptor agonists and ... |
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Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg |
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Collection: Biology and Medicine |
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| 31 | Appendix Chapter 8 8.1 Summary | ||
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Summary: of agonist induced stimulation of the 5-HT7 receptor. At the present, increasing numbers of pharmacological... new ligands that are able to stimulate the receptor (agonists). Additionally, we intended to make use... pharmacological profiles. The design of new 5-HT7 receptor ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 32 | DOI: 10.1126/science.1146317 , 815 (2007);318Science | ||
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Summary: Agonists TARP Auxiliary Subunits Switch AMPA Receptor www.sciencemag.org (this information is current... .sciencemag.orgDownloadedfrom #12;TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial Agonists Karen Menuz,1... regulatory proteins (TARPs), which are AMPA receptor ... |
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Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine |
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| 33 | doi:10.1152/ajpgi.90285.2008 295:78-87, 2008. First published May 15, 2008;Am J Physiol Gastrointest Liver Physiol | ||
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Summary: -purified antibodies directed against the COOH terminus of the CB2 receptor: CB22-A (1:250, Alpha Diag- nostics, Alpha... by cannabinoid (CB)2 receptor agonists in vivo, but the site and mechanism of action are unknown. We have tested... field stimulation was applied in the presence or ... |
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Source: Buckley, Nancy E. - Biological Sciences Department, California State Polytechnic University at Pomona |
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Collection: Biology and Medicine |
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| 34 | JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004 | ||
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Summary: functional and behavioral responses to D1 receptor stimulation, including cocaine or D1 agonist... are observed only at low doses of dopamine receptor agonist (2325). Figure 1. D1-like receptor signaling... intracellular stores following priming of the cells with a Gq- coupled ... |
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Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University |
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Collection: Biology and Medicine |
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| 35 | Sensitization by Extracellular Ca2 of Rat P2X5 Receptor and | ||
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Summary: reducing agonist potency. For P2 receptor antagonists, the potency order at rP2X5 was pyridoxal-5-phos... -ATP Ip5I PPADS suramin RB-2. Thus, the Ca2 -sensitized homomeric rP2X5 receptor is similar in agonist... -containing Ringer solution (1.8 mM Ba2 ) to investigate P2X5 receptor run- ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 36 | The state of GPCR research in 2004 (20 Questions) Nat Rev Drug Discov. 2004 Jul;3(7):575, 577-626. | ||
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Summary: will changing views of agonist and antagonist behaviour at GPCRs change the 588 way we view these receptors... of receptor distribution, their principal functions and agonist versus antagonist activity. Expression... for the analysis of ternary complex formation (the complex consisting of ... |
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Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University |
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Collection: Biology and Medicine |
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| 37 | P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a | ||
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Summary: of the agonist. The ATP-evoked currents at the rat P2X7 receptor is inhibited by ions such as calcium, magnesium... receptor agonists (Chootip et al., 2000). In contrast, the stable ATP analogs ,-meATP and ,-meATP are some... of the most useful agonists at P2X ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 38 | Pharmacological characterization of serotonin receptor subtypes modulating primary aerent input to deep dorsal horn neurons in | ||
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Summary: University, Atlanta, Georgia, GA 30322, U.S.A. 1 Spinal cord slices and whole-cell patch clamp recordings... . Similarly, the 5-HT1/7 receptor agonist, 5-carboxamidotryptamine (5-CT) depressed synaptic responses... antagonist. In the absence of any agonist, 5-HT1A ... |
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Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 39 | G Protein-coupled Receptors II. MECHANISM OF AGONIST ACTIVATION* | ||
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Summary: G Protein-coupled Receptors II. MECHANISM OF AGONIST ACTIVATION* Ulrik Gether and Brian K. Kobilka... : the nature of the physical changes in receptors that link agonist binding to G protein activation... on two questions. What conformational changes take place during receptor activation? ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 40 | Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational | ||
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Summary: ), 2aa2 (AS4), 7 S810L MR? Mineralocorticoid receptor, agonist--bound 1y9r_a (1CA), 2aa6_a (STR), 1ya3... , respectively [10, 11]. Progesterone receptor (PR) agonists have several important applications in women... -based identification of potential nuclear ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 41 | Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety | ||
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Summary: hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol 119:835844. Valera S, Hussy N, Evans RJ, Adami... did not show significant activity. For the rP2X1 receptor, ApnAs and ApnGs were partial agonists... ; for the P2X3 receptor, only Ap5G was full ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 42 | Research Focus Glutamate receptors: variation | ||
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Summary: receptors. An appreciation of the coupling between agonist binding and channel opening has advanced rapidly... ] presents structural data describing agonist-binding domains of an NMDA receptor subunit. Understanding... agonist binding and channel activation. Glutamate ... |
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Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 43 | International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors | ||
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Summary: of selective agonists and antagonists to some of the P2Y receptor subtypes. There are new findings about... agonists for some leukotriene receptors and some P2Y receptors has been found (see section IX.C.1... P2Y receptor to distinct G proteins and signaling pathways ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 44 | 14 Bushan, M. et al. (2002) Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial. Br. J. Dermatol. 146, 824831 | ||
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Summary: : a randomized trial. Br. J. Dermatol. 146, 824831 15 Maly, P. et al. (1996) The a(1,3)fucosyltransferase Fuc... to known members of the P2Y receptor family (which use simpler nucleotides as their agonists), but also... of agonist receptor interactions, has ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 45 | Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance | ||
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Summary: GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as well... heterodimerization between purinergic receptor subtypes has been reported for A1R and P2Y1R in both transfected cells... dopamine receptors ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 46 | Contribution of Valine 70 Gating of Neuronal a3 Receptor Subtypes | ||
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Summary: ). The same is true for a3b4 receptors sub- types (a3b4, 1.3 6 0.01; V70 A, 1.6 6 0.2; V70 S, 1.4 6 0.18; V70... .2; and V70 Y, 1.1 6 0.3). For a3b4 receptor subtypes, the estimated nH were (a3b4, 1.4 6 0.04; V70 A, 1.7 6... ) of the channel after prolonged exposure to ... |
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Source: Lasalde Dominicc, Jose A. - Department of Biology, Universidad de Puerto Rico - Rio Piedras |
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Collection: Biology and Medicine |
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| 47 | doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol | ||
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Summary: of the following adenosine receptor- selective agonists to induce changes in membrane capacitance: the A1-selective... similar to the reported KD ( 1 nM) this agonist has for A1 receptors (12). The A2a- selective ... |
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Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh |
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Collection: Biology and Medicine |
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| 48 | Novel 5-HT7 receptor inverse agonists. Synthesis and Molecular Modeling Chapter 7 7 Novel 5-HT7 receptor inverse agonists. Synthesis and | ||
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Summary: Novel 5-HT7 receptor inverse agonists. Synthesis and Molecular Modeling Chapter 7 149 7 Novel 5-HT7... receptor inverse agonists. Synthesis and Molecular Modeling of Arylpiperazine- and 1... #12;Chapter 7 Novel 5-HT7 receptor inverse agonists. Synthesis and Molecular ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 49 | Z .Brain Research 793 1998 244254 Research report | ||
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Summary: of cortical neurons. Using a selective agonist for V vasopressin receptor, the data show that V1a1 vasopressin... agonist and 100 nM V antagonist alone for 60 min. A1 1a second set of cultures was pre-exposed to 100 nM V... of these studies ... |
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Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California |
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Collection: Biology and Medicine |
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| 50 | Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells | ||
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Summary: -cyclopentylxanthine (DPCPX) as inverse agonists at the adrenergic 2A and adenosine A1 receptors, respectively (38, 39... a fluorescent receptor (A1-YFP) was able to couple to a fluorescent PTx resistant G protein (Go-CFP) (29). Fig... fused the C ... |
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Source: Xiang, Kevin Y. - Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign |
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Collection: Biology and Medicine |
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| 51 | In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to | ||
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Summary: inverse agonists of the adenosine A2B receptor from A2B receptor antagonists. As a result, three inverse... mutants did not respond to our tested inverse agonists. Based on these findings we conclude that receptors... agonists. In Chapter 5 the activation of the ... |
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Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden |
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Collection: Physics |
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| 52 | PERSPECTIVE New Determinants of Receptor-Effector Coupling: Trafficking | ||
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Summary: of caveolae-related GPCR translocation, including cardiac 2-adrenergic and A1 adenosine receptors that move... :741 750. Lasley R, Prakash N, Uittenbogaard A, and Smart E (2000) Activated cardiac adenosine A1 receptors... out of caveolin-rich membranes upon ... |
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Source: Ostrom, Rennolds - Department of Pharmacology, University of Tennessee Health Science Center |
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Collection: Biology and Medicine |
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| 53 | D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties* | ||
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Summary: for heterodimerization has recently been provided for dopamine D1 and adenosine A1 receptors as well as for dopamine D2... receptor forms hetero-oligomers with the adenosine A1 receptor. As the issue of G protein-coupled ... |
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Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science |
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Collection: Biology and Medicine |
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| 54 | PERSPECTIVE Agonist Binding: A Multistep Process | ||
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Summary: basis of G protein-coupled receptor (GPCR) activation by agonists has been the focus of much experimen... studies provide evi- dence for at least one intermediate conformational state in agonist bound receptor... -resolved peptide binding studies on the neuro- kinin receptor revealed that ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 55 | Agonist-activated ion channels *David Colquhoun | ||
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Summary: . & SIVILOTTI, L.G. (2004). The activation mechanism of a1 homo- meric glycine receptors. J. Neurosci., 24, 895... of the pharmacologist's stock in trade, the action of an agonist on a receptor to produce a response. Looked... of the pharmacologist's stock in trade, the action of an ... |
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Source: Colquhoun, David - Department of Pharmacology, University College London |
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Collection: Biology and Medicine |
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| 56 | doi:10.1152/ajpgi.00147.2006 291:605-610, 2006. First published May 4, 2006;Am J Physiol Gastrointest Liver Physiol | ||
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Summary: , and adenosine A1 receptors) are capable of mediating sustained contraction via sequential activation of PI 3... by receptor inactivation. The selective S1P1 receptor agonist SEW2871 did not stimulate PLC- or Rho kinase... activity or induce initial and sustained ... |
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Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University |
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Collection: Biology and Medicine |
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| 57 | Behavioral/Systems/Cognitive Conversion of the Modulatory Actions of Dopamine on | ||
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Summary: )decreasedMSRamplitudesinbothgroups,butalwaysmorestronglyinWT.Like low dopamine, the D3 receptor agonists pergolide and PD 128907 reduced MSR amplitude in WT but not D3... re- flex excitability is not well known, except that D2-like receptor agonists depress monosynaptic... the effects of dopamine and D2-like ... |
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Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 58 | Purine and pyrimidine receptors G. Burnstock | ||
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Summary: by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B and A3, have been cloned and charac- terised [2225]. All... observed in the ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 59 | Purine and pyrimidine receptors G. Burnstock | ||
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Summary: , complementary DNAs (cDNAs) encoding two different P1 receptor subtypes (A1 and A2) were isolated [20], and... , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... transmembrane domain. Polymorphisms have been ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 60 | A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2 | ||
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Summary: kinetics as well as agonist potency and selectivity. The AMPA receptor GluR2, with mutations in Tyr- 450... the agonist efficacy and the desensitization kinetics of the AMPA receptor GluR2. The ionotropic glutamate... -per- meable pore. The kinetic properties of the receptor activity are ... |
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Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 61 | JOURNAL OF EXPERIMENTAL ZOOLOGY 284:729741 (1999) 1999 WILEY-LISS, INC. | ||
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Summary: had both agonistic and antagonistic actions on the pharyngeal ACh receptor. Hexamethonium The effects... -dependent. Pretreatment with 100 µM hexamethonium had no effect on the subse- quent ACh-induced response (Fig. 9A1, A2... - tinic agonists known, although it has considerably lower ... |
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Source: O'Gara, Bruce A. - Department of Biological Sciences, Humboldt State University |
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Collection: Biology and Medicine |
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| 62 | Neuropharmacology 39 (2000) 364371 www.elsevier.com/locate/neuropharm | ||
|
Summary: . Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes... -opioid receptor (rivaling morphine in both their potency as agonists and their analgesic activity), they are also... activation of the µ-opioid ... |
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Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science |
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Collection: Biology and Medicine |
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| 63 | Brain Research 943 (2002) 117131 www.elsevier.com/locate/bres | ||
|
Summary: Res. 451a 1a (1997) 138] was translated into functional receptors by investigating the effector... was ([Phe ,Orn ]-vasotocin) and the linear V receptor antago-1a 1 2 6,8 9 terminated by the addition of 750... receptor, the ... |
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Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California |
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Collection: Biology and Medicine |
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| 64 | Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X3 and P2X2/3 receptors and between two | ||
|
Summary: I. ATP was used as the agonist at 3 mM and 10 mM for P2X3 and P2X2 receptors respectively, while 1 m... . In the presence of Ip5I, the peak amplitude of agonist evoked responses at P2X2 and P2X2/3 receptors were... ®cant. Concentration-response data were ®tted with the Hill equation: ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 65 | A fluorophore attached to nicotinic acetylcholine receptor M2 detects productive binding of | ||
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Summary: A fluorophore attached to nicotinic acetylcholine receptor M2 detects productive binding of agonist... (7). In the prevailing kinetic scheme, receptors in the resting state bind two agonist molecules... , the agonistreceptor complex disso- ciates and the channel closes within ... |
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|
Source: Bezanilla, Francisco - Department of Biochemistry and Molecular Biology, University of Chicago; Lester, Henry - Division of Biology, California Institute of Technology |
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Collection: Biology and Medicine |
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| 66 | Nicotine binding to brain receptors requires a strong cationp interaction | ||
|
Summary: stoichiometry of (a1)2b1cd. However, the a4b2 receptor can have variable stoichiometry. In particular... characterization of agonist-induced responses. Rat a4b2 and mouse (a1)2b1cd ion channels were expressed in Xenopus... experiments in the muscle-type ... |
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|
Source: Lester, Henry - Division of Biology, California Institute of Technology |
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Collection: Biology and Medicine |
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| 67 | Cellular/Molecular An Arginine Involved in GABA Binding and Unbinding But | ||
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Summary: - ated with gating. Therefore, 2-R207 is important for stabilizing the agonistreceptor complex, and may... agonist). After a brief (2 msec) pulse of saturating GABA, currents from 1 2-R207C receptors deacti- vated... .Thesolidlinesarefittotheequation; percentage recovery 100 100 * [a1 ... |
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|
Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 68 | JournalofPhysiology It has long been known that tetraethylammonium (TEA), | ||
|
Summary: interactions of TEA with the agonist binding Activation and block of mouse muscle-type nicotinic receptors... k_1 k_2 a k_d Model1 In model 1, A represents an agonist molecule (CCh), C a receptor with a closed... agonist of the nicotinic receptor. Sample currents ... |
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|
Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 69 | Current Topics Oligomerization of G Protein-Coupled Receptors: Past, Present, and Future | ||
|
Summary: used to describe the interaction between an agonist and its receptor. Scheme 1 describes Clark... 's occupancy theory (8). In Clark's theory, an agonist (A) will combine with the receptor (R) to form... an agonist-receptor complex (AR). The level of the AR complex present at thermodynamic ... |
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|
Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 70 | Z .European Journal of Pharmacology 405 2000 7388 www.elsevier.nlrlocaterejphar | ||
|
Summary: of potentiation.1 Pre-exposure of vasopressin V receptor agonist for 60 s resulted in a1 75% potentiation... receptor within a1 circumscribed time window yielded greater potentiation than simultaneous exposure... - epinephrine and vasopressin V ... |
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|
Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California |
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|
Collection: Biology and Medicine |
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| 71 | SPECIAL ISSUE Glycine receptors: recent insights into their | ||
|
Summary: -oligomeric a1 GlyR has allowed identification of several key residues important for agonist and/or antagonist... by single-particle tracking, which allowed single recombinant a1 receptors in the membrane of transfected... potent on ... |
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|
Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 72 | School of Life Sciences School of Engineering IBI Institute of Bioengineering / Institut de bioingnierie | ||
|
Summary: . Although agonist-dependent endocytosis of G protein coupled receptors (GPCRs) as a means to modulate... receptor signaling has been widely studied, the constitutive endocytosis of GPCRs (agonist- independent... ibi@epfl.ch http://ibi.epfl.ch/ IBI SEMINAR ANNOUNCEMENT "G protein-coupled ... |
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|
Source: Floreano, Dario - Laboratory of Intelligent Systems, Ecole Polytechnique Fédérale de Lausanne |
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|
Collection: Computer Technologies and Information Sciences ; Engineering |
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| 73 | 5-HT Receptors and the Neuromodulatory Control of | ||
|
Summary: ................................................................................................ 9 3.2 5-HT1A/1B receptors facilitate the induction of long-term depression... the low expression of 5-HT2A/2C receptors in the dorsal horn (see Section 2.2.2). 3.2 ... |
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|
Source: Hochman, Shawn - Department of Physiology, Emory University |
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|
Collection: Biology and Medicine |
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| 74 | Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins | ||
|
Summary: of cellular functions by interacting with specific cell surface G protein-coupled receptors (A1, A2a, A2b... Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor... in the agonist-mediated recruitment of the A2b ... |
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|
Source: Hall, Randy A - Department of Pharmacology, Emory University |
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|
Collection: Biology and Medicine |
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| 75 | Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking* | ||
|
Summary: provided by Robert Lefkowitz (Duke University Medical Center). 1A-, 1B-, and 1D-adrenergic receptor... 2 het- erodimer to markedly enhance GABAB receptor inter- nalization in response to agonist... , 1st 3 lanes). Conversely, GST alone did not detectably pull down any ... |
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|
Source: Teissére, Jeremy Alden - Biology Department, Muhlenberg College |
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|
Collection: Biology and Medicine |
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| 76 | Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking* | ||
|
Summary: (Duke University Medical Center). 1A-, 1B-, and 1D-adrenergic receptor constructs were kindly provided... 2 het- erodimer to markedly enhance GABAB receptor inter- nalization in response to agonist... with an antibody against the 2 subunit (Fig. 5A, ... |
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|
Source: Hall, Randy A - Department of Pharmacology, Emory University |
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|
Collection: Biology and Medicine |
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| 77 | Brain Research 869 (2000) 178185 www.elsevier.com/locate/bres | ||
|
Summary: peptideprotein conju- phase shifts, roles for both 5-HT and the 5-HT re-5A 1B 7 gate abolished... .g. attributed to the serotonergic pathway from the MRN to 5-HT , 5-HT , 5-HT , 5-HT , 5-HT , 5-HT , 5-1A 1B 1D 1... the case, then the rat behavioral rhythms with serotonergic agonists, J. ... |
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|
Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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|
Collection: Biology and Medicine |
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| 78 | Neuron, Vol. 19, 837848, October, 1997, Copyright 1997 by Cell Press Dopamine D3 Receptor Mutant Mice | ||
|
Summary: ., 1983) and conditioned cueMontreal, PQ H3A 1B1 preference (CCP) (Kelsey et al., 1989; Everitt et al... to combined injections D3 receptors have been implicated in the regulationof D1 and D2 class receptor agonists... on D3 receptor agonist with ... |
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|
Source: Graybiel, Ann M. - McGovern Institute for Brain Research & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT) |
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|
Collection: Biology and Medicine |
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| 79 | 2C-Adrenergic Receptors Exhibit Enhanced Surface Expression and Signaling upon Association with | ||
|
Summary: Center, Durham, NC). 1A-, 1B-, and 1D-Adrenergic receptor constructs were kindly provided by Ken Minneman... /2. Furthermore, analyses of agonist-pro- moted receptor endocytosis demonstrated enhanced 2CAR internalization... differentially by receptor ... |
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|
Source: Hall, Randy A - Department of Pharmacology, Emory University |
|||
|
Collection: Biology and Medicine |
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| 80 | Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm | ||
|
Summary: subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... receptor (Camaioni et al., 1998). The use of characteristic agonist potency profiles and effective... as an agonist at the recombinant P2X2 ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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|
Collection: Biology and Medicine |
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| 81 | Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: Biochemical and molecular modeling study | ||
|
Summary: are important for binding of ligands to the dopamine D2 [71], a1A adrenergic [72] and adenosine receptors [73... .05.008 #12;1. Introduction 8-OH-DPAT is a prototypical 5-HT1A receptor agonist [1]. During the last 25 years... that at postsynaptic 5- HT1A receptors in ... |
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|
Source: Skolnick, Jeff - Center for the Study of Systems Biology, Georgia Institute of Technology |
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|
Collection: Chemistry ; Biology and Medicine |
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| 82 | Progress in Neurobiology 70 (2003) 387407 Kainate receptors and synaptic transmission | ||
|
Summary: - sure to the GABAB receptor agonist baclofen (10 M), the A1 adenosine receptor agonist 2-chloroadenosine... M CGP55845) or adenosine A1 (0.1 M DPCPX) receptors. Similar results were obtained by Kamiya... , ... |
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|
Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis |
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|
Collection: Biology and Medicine |
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| 83 | Vasoactive Receptors in Abdominal Blood Vessels of the Dogfish Shark, Squalus acanthias | ||
|
Summary: Raton, Fla. #12;Shark Blood Vessel Receptors 125 Evans D.H. 1992. Evidence for the presence of A1 and A2... . The effect of the addition of the ETB-receptor agonist SRX S6c versus the ETA/ETB-receptor agonist ET... of the addition of the ... |
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|
Source: Evans, David H. - Department of Biology, University of Florida |
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|
Collection: Environmental Sciences and Ecology |
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| 84 | Structural aspects of AMPA receptor activation, desensitization and deactivation | ||
|
Summary: the full- length receptor, it is expected that agonist-induced domain closures couple to the channel... of the closed conformation of the agonist-bound ABD influence receptor properties? Using mutagenesis... receptors [27]. Use of kinetic models to quantify the contributions made by ... |
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|
Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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|
Collection: Biology and Medicine |
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| 85 | Functional Contribution of a3L80 Neuronal Nicotinic a3 Receptor | ||
|
Summary: for DMPP at both receptors. The Phe mutation also reduced the intrinsic activity of all agonists tested... at both receptors. The Tyr mutation, though, led to a decrease in intrinsic activity for all agonists... of four different polypeptide subunits (a1, b1, g or e, ... |
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|
Source: Lasalde Dominicc, Jose A. - Department of Biology, Universidad de Puerto Rico - Rio Piedras |
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|
Collection: Biology and Medicine |
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| 86 | J Physiol 586.18 (2008) pp 44254439 4425 Activation of recombinant NR1/NR2C NMDA receptors | ||
|
Summary: was exceptionally low, being 0.011 ± 0.002 in patches containing a single active receptor (n = 8). Fast agonist... closed times in the data record reflect closure of agonist-bound receptors within an activation... of glutamate and glycine. Correlations for glycine and nicotinic ... |
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|
Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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|
Collection: Biology and Medicine |
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| 87 | PII: SO028-3908(97)OO066-X Neuropharnracology,Vol.36,No.6,pp.853863,1997 | ||
|
Summary: ) receptors (Paternain et al., 1995; Spruston et al., 1995) and because most agonists and antagonists of non... , the steady-state potency of the various agonists to induce desensitizationof kainate receptors has not been... pA 1 2.5 S c 2S,4R-4MG Kainate Glutamate ... |
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|
Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis |
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|
Collection: Biology and Medicine |
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| 88 | Evidence of a specific role for 5-HT2A and 5-HT7 receptors in hindlimb stepping generation induced pharmacologically in paraplegic mice. | ||
|
Summary: Evidence of a specific role for 5-HT2A and 5-HT7 receptors in hindlimb stepping generation induced... City, Canada. 2. Department of Physiology, Emory University, Atlanta. Serotonin (5-HT) receptor... agonists such as quipazine and 8-OH-DPAT can induce `automatic' locomotor movements in the hindlimbs |
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|
Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 89 | Role of delivery and trafficking of d-opioid peptide receptors in opioid | ||
|
Summary: equipotent analgesic effects. Because experiments in animals show that DOP receptor agonists produce much... for new analgesics. However, in most cases, DOP receptor agonists induce weak or moderate analgesia... are inserted into the plasma membrane in response to DOP receptor ... |
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|
Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences |
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Collection: Biology and Medicine |
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| 90 | Novel Treatment for Stroke, Brain Trauma, Alzheimer's Disease and | ||
|
Summary: while co-administering glycine (the co-agonist of NMDA receptors) and an NR2B-specific antagonist... of NR2A-containing NMDA receptors to treat acute brain injuries such as stroke, neurotrauma, epilepsy... NMDA receptors that promotes cell survival · Does not potentiate NMDA receptors ... |
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|
Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia |
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|
Collection: Engineering |
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| 91 | The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor | ||
|
Summary: the pharmacological characterization of novel receptors. Moreover, adenosine A1 and P2Y1 receptors have been shown... previously to form heterodimers that enable the A1 receptor to bind and respond to ADP [6], and thus... antagonist. It is in ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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|
Collection: Biology and Medicine |
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| 92 | Glutamatergic and GABAergic Agonists Increase ]i in Avian Cochlear Nucleus Neurons | ||
|
Summary: but lack the a1-receptor subunit that nor- mally defines type I receptors (Hyson and Sadler, 1997... stimulated by glutamate- and GABA-receptor agonists using a chicken brainstem slice preparation... stores. Whereas GABA-A receptor ... |
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|
Source: Rubel, Edwin - Department of Physiology and Biophysics, University of Washington at Seattle |
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Collection: Biology and Medicine |
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| 93 | Spinal neurons are sensitized following stimuli that activate nociceptors. This central sensitization is | ||
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Summary: used were 5-carboxamidotryptamine (5-CT), a 5-HT1A/1B receptor agonist; 8-hydroxy-2-(di... 5-HT2C receptor agonist (not illustrated). Agonists selective for the 5-HT1A/1B, 5-HT2A or 5-HT7... indicated an ... |
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|
Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 94 | ABBREVIATIONS: NMDA, N-methyl-D-aspartate; AMPA, ct-amino-3-hydroxy-4-methylisoxazolepropionic acid; DDB, 2,5-dihydro-2,5-dioxo-1H-ben-zazepine; DDHB, 2,5-dihydro-2,5-dioxo-3-hydroxy-1H-benzazepine; 4-Br-DDHB, 7-Me-DDHB, and 8-Me-DDHB, 4-bromo, 7-methyl, | ||
|
Summary: dissociation constant of 8-Me-DDHB for non-NMDA receptors was 6.4 M when kainate was the agonist and 9.6 M when... two receptor subtypes that are directly coupled to ion channels (1, 2). NMDA is a selective agonist... neurons, non-NMDA receptors exhibit rapid desensitization to the ... |
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|
Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis |
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|
Collection: Biology and Medicine |
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| 95 | Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury | ||
|
Summary: . Neither the A1 receptor agonist 2-chloro-N6 -cyclo- pentyladenosine (0.05 mg/kg) nor the A2A receptor... to investigate a potential protective role of adenosine A1, A2A, and A3 receptor agonists in both ... |
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|
Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa |
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|
Collection: Biology and Medicine |
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| 96 | Kinase cascades and ligand-directed signaling at the kappa opioid receptor | ||
|
Summary: . (2000) demonstrated that the N- terminal 7 residues of dynorphin A(117) were critical for KOR receptor... and K+ channels. In addition, KOR agonists activate kinase cascades including G-protein coupled Receptor... nucleotides, including GTP, regulate agonist ... |
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|
Source: Bruchas, Michael R. - Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 97 | Biochem. J. (2001) 354, 485491 (Printed in Great Britain) 485 Tyr199 in transmembrane domain 5 of the 2-adrenergic receptor interacts | ||
|
Summary: an important role in the interaction of the receptor with the catechol end of adrenergic agonists. However... +-nitrilotriacetate; Endo Lys-C, endoproteinase Lys-C; Con A, concanavalin A. 1 Present address: Du... involved in agonist activation of the beta- adrenergic ... |
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|
Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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|
Collection: Biology and Medicine |
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| 98 | An aplysia dopamine1-like receptor: molecular and functional characterization | ||
|
Summary: is a constitutively active receptor. We next tested the ability of flupentixol to act as an inverse agonist... is an inverse agonist for this receptor. (a) (b) i ii iviii Fig. 4 Expression of the Apdop1 receptor at the cell... receptor. (a) ... |
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|
Source: Byrne, John H. - Department of Neurobiology and Anatomy, University of Texas Medical School at Houston |
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|
Collection: Biology and Medicine |
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| 99 | Pharmacological characterization of (4R)-alkyl glutamate analogues at the ionotropic glutamate receptors --Focus on subtypes iGlu57 | ||
|
Summary: Glu5 receptor subtype, as the alkyl group is extended in length and bulk (1a 1g, 2a 2f and AMPA ATPA... Glu (2f) have all previously been reported as selective agonists for the iGlu5 receptor subtype... and Krogsgaard-Larsen, 2009 L. Bunch and P. Krogsgaard-Larsen, Subtype selective ... |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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|
Collection: Mathematics |
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| 100 | Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson | ||
|
Summary: ] may also negatively modulate the antinociceptive effects of A1-receptor agonists [45]. The rostral... as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... breakdown to ADO, it acts as a ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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|
Collection: Biology and Medicine |
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