E-print Network

Sample records for auriculo ventricular congenito

  1. Ventricular torsional relation to ventricular fiber arrangement

    CERN Preprints

    Ranjbar, Saeed; Meybodi, Mahmood Emami

    2014-01-01

    Left ventricular torsion from helically oriented myofibers is a key parameter of cardiac performance. Physicians observing heart motion on echocardiograms, during cardiac catheterization, or in the operating room, are impressed by the twisting or rotary motion of the left ventricle during systole. Conceptually, the heart has been treated as a pressure chamber. The rotary or torsional deformation has been poorly understood by basic scientists and has lacked clinical relevance. The aim of this paper attempts to discuss about this question: Is ventricular twisting related to ventricular fiber arrangement? That is dependent to an assumed model of the left ventricular structure.

  2. Are Nonlinear Ventricular Arrhythmia Characteristics Lost, as Signal Duration Decreases?

    Engineering Websites

    Povinelli, Richard J.

    Are Nonlinear Ventricular Arrhythmia Characteristics Lost, as Signal Duration Decreases? RJ, nonlinear, phase space based method to quickly and accurately identify life-threatening arrhythmias, have proven to be effective therapy for terminating such ventricular arrhythmias. There is evidence [2

  3. Miniaturization of a left ventricular assist device 

    Texas A&M University - TxSpace

    Milios, Gregory Scott

    1996-01-01

    An important aspect to the success of a left ventricular assist device is that it exist in a form which is convenient for patient usage. A compact unit which can easily be carried during normal activities is essential when considering long term...

  4. Surface Registration for Ventricular Morphometry Analysis in Mild Cognitive Impairment

    Mathematics Websites

    Wang, Yalin

    are then used as boundary conditions for ventricular surface registration. Methods Fig. 1 summarizes the key ventricular surface as shown in Fig. 1 (a). The process is called topology optimization. Two paths connecting consistent endpoints of existing boundaries (as show in Fig. 1 (b), points with the same colors) are traced

  5. Phase resetting of spontaneously beating embryonic ventricular heart cell aggregates

    Biology and Medicine Websites

    Guevara, Michael R.

    Phase resetting of spontaneously beating embryonic ventricular heart cell aggregates MICHAEL R embryonic ventricular heart cell aggregates. Am. J. Physiol. 251 (Heart Circ. Physiol. 20): Hl298-Hl305 OF A SINGLE premature stimulus to the heart can result in dramatic changes in its rhythmic activity

  6. A novel approach for the diagnosis of ventricular tachycardia based on phase space reconstruction of ECG

    CERN Preprints

    Koulaouzidis, George; Cappiello, Grazia; Mazomenos, Evangelos B; Maharatna, Koushik; Morgan, John

    2014-01-01

    Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to ventricular tachyarrhythmia in patients with and/or without structural heart disease. Ventricular fibrillation (VF) and ventricular tachycardia (VT) are the most common electrical mechanisms for cardiac arrest. Accurate and automatic recognition of these arrhythmias from electrocardiography (ECG) is a crucial task for medical professionals. The purpose of this research is to develop a new index for the differential diagnosis of normal sinus rhythm (SR) and ventricular arrhythmias, based on phase space reconstruction (PSR).

  7. The formation and function of the brain ventricular system

    MIT - DSpace

    Chang, Jessica T. (Jessica Tzung-Min)

    2012-01-01

    The brain ventricular system is composed of a highly conserved set of cavities that contain cerebrospinal fluid (CSF), a protein-rich fluid essential for brain function. However, little is known about the function of ...

  8. Towards short-term forecasting of ventricular tachyarrhythmias

    MIT - DSpace

    Santos, Gustavo Sato dos

    2006-01-01

    This thesis reports the discovery of spectral patterns in ECG signals that exhibit a temporal behavior correlated with an approaching Ventricular Tachyarrhythmic (VTA) event. A computer experiment is performed where a ...

  9. Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment

    Biology and Medicine Websites

    Thompson, Paul

    Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment Liana), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment Inc. All rights reserved. Keywords: Parkinson disease; Mild cognitive impairment; MCI; Brain atrophy

  10. Cardiac conduction and resistanceCardiac conduction and resistance to ventricular fibrillation in Siberianto ventricular fibrillation in Siberian

    Engineering Websites

    at the intercalated disks revealed in a single ventricular cardiac myocyte by immunoconfocal microscopy (connexin43 (connexons). (E) Each channel consists of two connexons, and each connexon of six connexins. Different types of connexin are denoted using a s

  11. The Mathematical Modelling of Inhomogeneities in Ventricular Tissue

    Nonlinear Sciences (arXiv)

    T. K. Shajahan; Sitabhra Sinha; Rahul Pandit

    2007-03-25

    Cardiac arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF) are the leading cause of death in the industrialised world. There is a growing consensus that these arrhythmias arise because of the formation of spiral waves of electrical activation in cardiac tissue; unbroken spiral waves are associated with VT and broken ones with VF. Several experimental studies have been carried out to determine the effects of inhomogeneities in cardiac tissue on such arrhythmias. We give a brief overview of such experiments, and then an introduction to partial-differential-equation models for ventricular tissue. We show how different types of inhomogeneities can be included in such models, and then discuss various numerical studies, including our own, of the effects of these inhomogeneities on spiral-wave dynamics. The most remarkable qualitative conclusion of our studies is that the spiral-wave dynamics in such systems depends very sensitively on the positions of these inhomogeneities.

  12. A two phase harmonic model for left ventricular function

    CERN Preprints

    Dubi, S; Dubi, Y

    2006-01-01

    A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude and the elastic constant of the oscillator are different. Taking into account the pressure within the left ventricle, the model shows qualitative agreement with functional parameters of the left ventricle. The model allows for a natural explanation of heart failure with preserved systolic left ventricular function, also termed diastolic heart failure. Specifically, the rise in left ventricular filling pressures following increased left-ventricular wall stiffness is attributed to a mechanism aimed at preserving heart rate and cardiac output.

  13. Elevated Strain and Structural Disarray Occur at the Right Ventricular Apex

    Biology and Medicine Websites

    Konofagou, Elisa E.

    , compared to the left ventricle and septum. Heterogeneous strain distributions, myocardial fiber disarray impositions in the right ventricle, respectively. Thus, these data demonstrate why the right ventricular apex Ventricular Cardiomyopathy RV Right ventricle LV Left ventricle RVA Right ventricular apex INTRODUCTION

  14. Right Ventricular Outflow Tract Reconstruction with Bicuspid Valved Polytetrafluoroethylene Conduit

    Engineering Websites

    Pekkan, Kerem

    . Methods: Since October 2008 to September 2009, we have implanted bicuspid valved PTFE conduits in eighteen of great arteries in one and interrupted aortic arch with a ventricular septal defect in one. In sixteen. Three-dimensional flow fields obtained from computational fluid dynamics studies are utilized

  15. UNCORRECTEDPROOF 1 Mapping genetic influences on ventricular structure in twins

    Biology and Medicine Websites

    Thompson, Paul

    the lateral ventricles, in 3D volumetric MRI 17 scans of 76 identical (monozygotic, MZ) twins (38 pairs; mean= ^ 7.3%), 25 common environment (C= ^ 38.9%) and unique environment (E= ^ 53.8%) to lateral ventricular volume. Earlier- 26 ^ maturing occipital horn regions may also be more genetically influenced than later

  16. CARDIOMYOPATHY Exercise-Induced Left Ventricular Systolic Dysfunction

    Biology and Medicine Websites

    Campbell, Kevin P.

    CARDIOMYOPATHY Exercise-Induced Left Ventricular Systolic Dysfunction in Women Heterozygous women each underwent standard exercise stress echocardiography. Results: Heterozygotes demonstrated.62 6 0.07, P = .02). After exercise, the mean LVEF fell to 0.53 6 0.14 in heterozygotes but rose to 0

  17. SURFACE-BASED COMPUTATIONAL ANATOMY TECHNIQUES REVEAL VENTRICULAR AND HIPPOCAMPAL ABNORMALITIES IN ADOLESCENTS

    Biology and Medicine Websites

    Thompson, Paul

    boundary points to their medial curves were analyzed using surface-based nonparametric regression. Shape in hippocampal and ventricular volumes were assessed with multivariate regression. Surface analyses revealed

  18. Ranking the Clinical and Pathological Correlates of Ventricular Expansion Mapped in 804 Alzheimer's

    Biology and Medicine Websites

    Thompson, Paul

    Ranking the Clinical and Pathological Correlates of Ventricular Expansion Mapped in 804 Alzheimer MRI scans from 184 AD, 391 MCI, and 229 healthy elderly controls. Radial expansion of the ventricles and pathological correlates of ventricular expansion, using detailed maps rather than simple volumetric summaries

  19. Totally tubular: the mystery behind function and origin of the brain ventricular system

    Biology and Medicine Websites

    Lowery, Laura Anne

    Totally tubular: the mystery behind function and origin of the brain ventricular system Laura Anne School, 240 Longwood Ave, Boston, MA, USA A unique feature of the vertebrate brain is the ventricular by neu- roepithelium. While CSF is critical for both adult brain function and embryonic brain development

  20. Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

    University of California eScholarship Repository

    Yamazaki, Katrina Go

    2009-01-01

    remodeling observed with ventricular dyssynchrony. 1.5 Myocardial structurestructure from various cardiac events, such as myocardial infarction, is known to lead to adverse ventricular remodeling.Structure ……………………………………….. 1.6 Triggering of Acute Inflammation …………………………… 1.7 Neutrophils, ROS, and the heart ……………………………….. v 1.8 Inflammation, MMPs, and cardiac remodeling …………………

  1. ARTICLE IN PRESS Mapping hippocampal and ventricular change in Alzheimer disease

    Biology and Medicine Websites

    Thompson, Paul

    ARTICLE IN PRESS Mapping hippocampal and ventricular change in Alzheimer disease Paul M. Thompson Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 an anatomical mapping technique to detect hippocam- pal and ventricular changes in Alzheimer disease (AD

  2. 100 J. Neurosurg. / Volume 109 / July 2008 HE pathogenesis of ventricular dilation in NPH re-

    Mathematics Websites

    Frey, Pascal

    properties of the brain parenchyma could favor or even cause ventricular di- lation at a normal pressure.12 Hakim et al.5 proposed that the brain could be considered as a porous viscoelastic material to be computed using FE analysis.13 So far, several studies have simulated ventricular dilation in 2D brain

  3. MULTIVARIATE TENSOR-BASED MORPHOMETRY ON SURFACES: APPLICATION TO MAPPING VENTRICULAR CHANGES IN HIV/AIDS

    Biology and Medicine Websites

    Thompson, Paul

    MULTIVARIATE TENSOR-BASED MORPHOMETRY ON SURFACES: APPLICATION TO MAPPING VENTRICULAR CHANGES subjects). Experimental results demonstrated that our method powerfully detected brain surface-Euclidean framework, detected group differences with greater power than other surface-based statistics includ- ing

  4. Thymosin beta 4 protects mice from monocrotaline-induced pulmonary hypertension and right ventricular hypertrophy 

    Texas A&M University - TxSpace

    Wei, Chuanyu; Kim, II-Kwon; Li, Li; Wu, Liling; Gupta, Sudhiranjan

    2014-11-20

    right ventricular hypertrophy (RVH) and RV failure. The pathology of PAH involves vascular cell remodeling including pulmonary arterial endothelial cell (PAEC) dysfunction and pulmonary arterial smooth muscle cell (PASMC) proliferation. Current therapies...

  5. Tornado in a dish: Revealing the mechanisms of ventricular arrhythmias in engineered cardiac tissues

    Biology and Medicine Websites

    Editorial Tornado in a dish: Revealing the mechanisms of ventricular arrhythmias in engineered) that the condition is caused by the re-entry of impulses and the formation of circles of excitation. Each

  6. Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions

    University of Cambridge - Dspace

    Tse, Gary; Yeo, Jie Ming

    2015-10-30

    Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those...

  7. Reentrant waves and their elimination in a model of mammalian ventricular tissue ?

    Mathematics Websites

    Biktashev, Vadim N.

    Preprint 29 June 1997 #12; The re­entrant ventricular arrhythmias of monomorphic ventricu­ lar tachycardia by ap­ propriately timed small amplitude, can be computed. 1 Introduction Some cardiac arrhythmias

  8. Mechanisms of Ventricular Fibrillation The role of mechano-electrical feedback

    Biology and Medicine Websites

    Utrecht, Universiteit

    .1 The Heart . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Cardiac Arrhythmias . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.2.1 Mechanisms of Cardiac Arrhythmias . . . . . . . . . . . . . 5 1.2.2 Mechanisms of Ventricular Fibrillation . . . . . . . . . . . . 6 1.2.3 Cardiac Arrhythmias and Mechano-Electrical Feedback

  9. Re-entrant waves and their elimination in a model of mammalian ventricular tissue?

    Mathematics Websites

    Biktashev, Vadim N.

    Preprint 29 June 1997 #12;The re-entrant ventricular arrhythmias of monomorphic ventricu- lar tachycardia by ap- propriately timed small amplitude, can be computed. 1 Introduction Some cardiac arrhythmias

  10. A novel means of cardiac catheter guidance for ablation therapy of ventricular tachycardia

    MIT - DSpace

    Lv, Wener

    2014-01-01

    This work presents a system for identifying the site of origin of ventricular tachycardia (VT) and guiding a catheter to that site in order to deliver radio-frequency (RF) ablation therapy. Myocardial infarction (MI), also ...

  11. Pediatric Mechanical Circulatory Support Thermal Analysis of the PediaFlow Pediatric Ventricular

    Engineering Websites

    Paden, Brad

    Pediatric Mechanical Circulatory Support Thermal Analysis of the PediaFlow Pediatric Ventricular during the system design and optimization process. The preliminary design stage of the PediaFlow project

  12. Computer simulation of a novel technique for Radio-Frequency Ablation of ventricular arrhythmias

    MIT - DSpace

    Rosbury, Tamara S

    2006-01-01

    Ventricular Tachycardia (VT) is a rapid arrhythmia, most commonly due to reentrant electrical activity in the heart. A common treatment for VT is Radio-Frequency Ablation (RFA), which is minimally invasive, but requires ...

  13. The RyR2-P2328S mutation downregulates Nav1.5 producing a ventricular arrhythmic substrate in murine ventricles.

    University of Cambridge - Dspace

    Ning, Feifei; Luo, Ling; Ahmad, Shiraz; Valli, Haseeb; Jeevaratnam, Kamalan; Wang, Tingzhong; Guzadhur, Laila; Yang, Dandan; Fraser, James A.; Huang, Christopher L. H.; Ma, Aiqun; Salvage, Samantha C.

    2015-11-06

    Catecholaminergic polymorphic ventricular tachycardia (CPVT) predisposes to ventricular arrhythmia due to altered Ca2+ homeostasis and can arise from ryanodine receptor (RyR2) mutations including RyR2-P2328S. Previous reports established...

  14. Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation

    Nonlinear Sciences (arXiv)

    Sitabhra Sinha; Ashwin Pande; Rahul Pandit

    2001-04-04

    Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart makes it incapable of any concerted pumping action. Methods of controlling ventricular fibrillation include electrical defibrillation as well as injected medication. Electrical defibrillation, though widely used, involves subjecting the whole heart to massive, and often counterproductive, electrical shocks. We propose a defibrillation method that uses a very-low-amplitude shock (of order mV) applied for a brief duration (of order 100 ms) and over a coarse mesh of lines on our model ventricle.

  15. Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular

    Biology and Medicine Websites

    Burnstock, Geoffrey

    expansion of the lateral ventricles in rat embryos. In the present study mRNAs for all known mammalianExpression and localization of P2 nucleotide receptor subtypes during development of the lateral in lateral ventricular choroid plexus in relation to recent studies of aquaporin-1 expression and rapid

  16. Cardiac Right Ventricular Segmentation via Point Correspondence Kumaradevan Punithakumar, Michelle Noga, and Pierre Boulanger

    Engineering Websites

    Alberta, University of

    . I. INTRODUCTION Assessment of right ventricular (RV) function is important in the diagnosis morphology and function, assessment of the RV is acknowledged as a more challenging problem than at end-systole than at end-diastole using the shape- based approaches. The results published

  17. Progress in Cardiology myosin binding protein C (cMBPC),6 ventricular myosin

    Biology and Medicine Websites

    Lee, Won-Ha

    (vMLC1), and ventricular regulatory light chain (vMLC2).7 The clinical expression of the disease of the disease may be due in part to genetic heterogeneity resulting from the existence of mutations in different disease genes or different mutations within a given gene. Several phenotype-genotype analyses have already

  18. A clinical feasibility study of atrial and ventricular electromechanical wave imaging

    Biology and Medicine Websites

    Konofagou, Elisa E.

    A clinical feasibility study of atrial and ventricular electromechanical wave imaging Jean Provost to be capable of noninvasively and trans- murally mapping the activation sequence of the heart in animal studies correlated with results from invasive intracardiac electrical mapping studies during intervention

  19. ARTICLE IN PRESS 3D mapping of ventricular and corpus callosum abnormalities in

    Biology and Medicine Websites

    Thompson, Paul

    computational anatomy techniques, we mapped how AIDS impacts the corpus callosum (CC) and ventricular system, two systems that show prominent changes on MRI. We (1) identified regions with greatest differences differences with measures of immune system deterioration and cognitive decline. Methods: 51 3D brain MRI scans

  20. Three-Dimensional Activation Mapping in Ventricular Muscle: Interpolation and Approximation of Activation Times

    Biology and Medicine Websites

    MacLeod, Rob S.

    Three-Dimensional Activation Mapping in Ventricular Muscle: Interpolation and Approximation mapping, which is widely used in research. While three-dimensional measurement of cardiac fields by means, fiber architecture, and the three-dimensional shape of the heart itself. Detecting the spread

  1. Hippocampal, Caudate, and Ventricular Changes in Parkinson's Disease with and Without Dementia

    Biology and Medicine Websites

    Thompson, Paul

    Hippocampal, Caudate, and Ventricular Changes in Parkinson's Disease with and Without Dementia: Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini- Mental State

  2. Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function in Dogs

    Engineering Websites

    Chesler, Naomi C.

    Drive, Madison, WI 53706-1609, USA Abstract Pulmonary hypertension (PH) can impact right ventricular (RV that monitoring of PH progression by noninvasive methods may be possible. Keywords Pulmonary arterial hypertension-text$watermark-text$watermark-text #12;INTRODUCTION Pulmonary arterial hypertension (PAH) is a devastating disease exhibiting fast

  3. Original article Marked differences between atrial and ventricular gene-expression remodeling in

    Biology and Medicine Websites

    Glass, Leon

    in dogs with experimental heart failure Sophie Cardin a,c,1 , Patricia Pelletier a,b,1 , Eric Libby d Article history: Received 26 June 2008 Received in revised form 12 August 2008 Accepted 12 August 2008-expression changes in CHF. Groups of dogs were submitted to ventricular tachypacing (VTP, 240 bpm) for 24 h or 2

  4. P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium

    Biology and Medicine Websites

    Burnstock, Geoffrey

    P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium Lele Jianga and connexins. In this study we examined the localization of P2X1 ionotropic receptors and their relation to connexin43 in gap junctions in human left ventricles. Methods and results: Using immunohistochemistry, we

  5. Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

    Biology and Medicine Websites

    Thompson, Paul

    Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects subjects' manually labeled brain MRI scans (atlases). We fluidly registered each atlas and mesh model, as the number of atlases, N, was increased from 1 to 9. In surface-based statistical maps, we detected more

  6. Validation of a novel catheter guiding method for the ablative therapy of ventricular tachycardia in a phantom model

    MIT - DSpace

    Hirschman, Gordon B.

    Accurate guidance of an ablation catheter is critical in the RF ablation (RFA) of ventricular tachycardia (VT). With current technologies, it is challenging to rapidly and accurately localize the site of origin of an ...

  7. Fuzzy Modeling to Predict Severely Depressed Left Ventricular Ejection Fraction following Admission to the Intensive Care Unit Using Clinical Physiology

    MIT - DSpace

    Dejam, Andre

    2015-01-01

    Left ventricular ejection fraction (LVEF) constitutes an important physiological parameter for the assessment of cardiac function, particularly in the settings of coronary artery disease and heart failure. This study ...

  8. Alternans and higher-order rhythms in an ionic model of a sheet of ischemic ventricular muscle

    Biology and Medicine Websites

    Guevara, Michael R.

    for publication 18 January 2000 Life-threatening arrhythmias such as ventricular tachycardia and fibrillation been implicated in inducing arrhythmias. We investigate an ionic model of a 3 cm 3 cm sheet of normal

  9. Terminating ventricular tachycardia by pacing induced dynamical inhomogeneities in the reentry circuit

    Nonlinear Sciences (arXiv)

    Sitabhra Sinha; Johannes Breuer

    2004-06-21

    Formation of feedback loops of excitation waves (reentrant circuit) around non-conducting ventricular scar tissue is a common cause of lethal cardiac arrhythmias, such as ventricular tachycardia. This is typically treated by rapid stimulation from an implantable device (ICD). However, the mechanisms of reentry termination success and, more importantly, failure, are poorly understood. To study such mechanisms, we simulated pacing of anatomical reentry in an ionic model of cardiac tissue, having significant restitution and dispersion properties. Our results show that rapid pacing causes inhomogeneous conduction in the reentrant circuit, leading to successful pacing termination of tachycardia. The study suggests that more effective pacing algorithms can be designed by taking into account the role of such dynamical inhomogeneities.

  10. Spiral Turbulence: From the Oxidation of CO on Pt(110) to Ventricular Fibrillation

    Nonlinear Sciences (arXiv)

    Ashwin Pande; Sitabhra Sinha; Rahul Pandit

    2000-01-27

    We give a brief overview of systems that show spiral patterns and spatiotemporally chaotic states. We concentrate on two physical systems: (1) the oxidation of CO on Pt(110) and (2) ventricular fibrillation in hearts. The equations that have been suggested as simple models for these two different systems are closely related for they are both {\\it excitable media}. We present these equations and give a short summary of the phenomena they yield.}

  11. Int Conf IEEE Engineering in Medicine and Biology Society 1999, pages 848-851 Three-Dimensional Regional Left Ventricular

    Biology and Medicine Websites

    Duncan, James S.

    -Dimensional Regional Left Ventricular Deformation from Digital Sonomicrometry Donald Dione , Pengcheng Shi, , Wayne. To determine regional 3D strains in the left ventricle of the heart we employed digital sonomicrometry scaling technique was then applied to transform the distances to 3D crystal coordinates. A least squares

  12. MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY-BASED COHORT

    Computer Technologies and Information Sciences Websites

    MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY of the cerebral ventricles with risk for and progression of dementia and MCI in elderly subjects [1] [3] [5 been proposed as a possible biomarker for estimating dementia risk or response to treatments. However

  13. MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY-BASED COHORT

    Biology and Medicine Websites

    Thompson, Paul

    ) image scan. The technique combines a robust, auto- mated technique for ventricular segmentation with a 3 volume measurements from structural MR or computed tomography (CT) images have been proposed This work was supported by NIH grants NS07391 , MH064625 , AG05133 , DA015900-01 , MH01077 , EB001561, RR

  14. Mapping genetic influences on ventricular structure in twins Yi-Yu Chou, Natasha Lepore, Ming-Chang Chiang, Christina Avedis-

    Biology and Medicine Websites

    Thompson, Paul

    was generously supported by NIH grant R01 HD050735 and National Health and Medical Research Council, Australia an automated system to visualize genetic and environmental effects on brain structure in large brain MRIÔØ Å ÒÙ× Ö ÔØ Mapping genetic influences on ventricular structure in twins Yi-Yu Chou, Natasha

  15. Quantitative analysis of cardiac motion is of great clinical interest in assessing ventricular function. Real-time 3-D

    Biology and Medicine Websites

    ventricular function. Real-time 3-D (RT3D) ultrasound transducers provide valuable three- dimensional in RT3D ultrasound. A myocardial displacement field and dynamic cardiac metrics were computed, but is still limited to two- dimensions in most hospitals and clinical centers. Development of 3D

  16. Three-Dimensional Geometric Modeling of Membrane-bound Organelles in Ventricular Myocytes: Bridging the Gap between

    Mathematics Websites

    Holst, Michael J.

    Three-Dimensional Geometric Modeling of Membrane-bound Organelles in Ventricular Myocytes: Bridging on membrane-bound organelles in ventricu- lar myocytes that are imaged and reconstructed with electron types of membrane-bound Ca2+ -handling organelles, namely, transverse tubules (T-tubules) and junctional

  17. Fractal Correlation Properties of R-R Interval Dynamics and Mortality in Patients With Depressed Left Ventricular

    Biology and Medicine Websites

    Left Ventricular Function After an Acute Myocardial Infarction Heikki V. Huikuri, MD; Timo H. Ma-R interval variability as predictors of death after acute myocardial infarction. Methods and Results assessed from 24-hour Holter recordings in 446 survivors of acute myocardial infarction with a depressed

  18. In Vitro Durability - Pivot bearing with Diamond Like Carbon for Ventricular Assist Devices

    CERN Preprints

    de Sá, Rosa Corrêa Leoncio; Leão, Tarcísio Fernandes; da Silva, Evandro Drigo; da Fonseca, Jeison Willian Gomes; da Silva, Bruno Utiyama; Leal, Edir Branzoni; Moro, João Roberto; de Andrade, Aron José Pazin; Bock, Eduardo Guy Perpétuo

    2015-01-01

    Institute Dante Pazzanese of Cardiology (IDPC) develops Ventricular Assist Devices (VAD) that can stabilize the hemodynamics of patients with severe heart failure before, during and/or after the medical practice; can be temporary or permanent. The ADV's centrifugal basically consist of a rotor suspended for system pivoting bearing; the PIVOT is the axis with movement of rotational and the bearing is the bearing surface. As a whole system of an implantable VAD should be made of long-life biomaterial so that there is no degradation or deformation during application time; surface modification techniques have been widely studied and implemented to improve properties such as biocompatibility and durability of applicable materials. The Chemical Vapour Deposition technique allows substrates having melting point higher than 300 {\\deg}C to be coated, encapsulated, with a diamond like carbon film (DLC); The test simulated the actual conditions in which the system of support remains while applying a ADV. The results hav...

  19. 2001 Proceedingsof the 23rd Annual EMBS International Conference, October 25-28, Istanbul, Turkey QUANTIFICATIONOF RIGHT AND LEFT VENTRICULAR FUNCTION

    Engineering Websites

    in patients with primary pulmonary hypertension. Dynamic analysis of the heart is performed via quantification and primary pulmonary hypertension (PPH) can result in an increase of the right ventricular volume and affect

  20. TOMM40 rs2075650, TOMM40 rs157580 and TOMM40 PolyT Polymorphism Effects on Ventricular Enlargement in Individuals with and without Mild Cognitive Impairment

    Biology and Medicine Websites

    Thompson, Paul

    subjects, presence of VL repeats associates with smaller lateral ventricles. These data complement our=0.039) and left occipital lateral ventricle horns (pcorrected= 0.014) in ApoE4-negative subjects157580 and TOMM40 polyT polymorphism on lateral ventricular enlargement in normal aging and the mild

  1. Added Spectral Features in ECGs From Patients With Ventricular Tachycardia Detected by Phase and Group-Delay Analysis Over the Cardiac Cycle

    Engineering Websites

    Arthur, R. Martin

    . Patients Studied 2. Data Acquisition and Signal Averaging Frank X-, Y-, and Z-lead ECGs were recordedAdded Spectral Features in ECGs From Patients With Ventricular Tachycardia Detected by Phase. Cain Washington University, St. Louis, MO ABSTRACT Fourier analysis of the signal-averaged ECG (SAECG

  2. J. Gorcsan, S. Mulukutla, H. Wang, D. Jacques, G. Stetten, A. Feldman, "Measurement of Left Ventricular Wall Motion Asynchrony in Patients with Left Bundle Branch Block Using Tissue

    Engineering Websites

    Stetten, George

    Ventricular Wall Motion Asynchrony in Patients with Left Bundle Branch Block Using Tissue Doppler in Patients with Left Bundle Branch Block Using Tissue Doppler Echocardiography John Gorcsan III, Suresh patients with left bundle branch block (LBBB) and heart failure (HF) by improving the synchrony of wall

  3. Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive Impairment using Multi-Atlas Fluid Image Alignment

    Biology and Medicine Websites

    Thompson, Paul

    with mild cognitive impairment (MCI), and 80 healthy controls. Surface averaging within subjects greatly morphology at baseline and (1) diagnosis, (2) cognitive performance (MMSE scores), (3) depression, and (4, were required to correlate ventricular enlargement with MMSE and clinical depression. Surface-based FDR

  4. Experimental Measures of Ventricular Activation and Synchrony

    Engineering Websites

    MacLeod, Rob S.

    Corporation, Minneapolis, Minnesota Background: A widened QRS complex as a primary indication for cardiac Association Western States Affiliate grant no. 0060129Y (BBP); and a grant from Boston Scientific Corporation (BBP), Guidant Corporation (BBP), and the NIH/NCRR Center for Integrated Biomedical Computing (CIBC, P

  5. UNCORRECTEDPROOF 1 Mapping correlations between ventricular expansion

    Biology and Medicine Websites

    Thompson, Paul

    reveals genetic effects ^ in Alzheimer's ^ disease, NeuroImage 40(2): 615­ ^ 630.); with this method, we biomarkers in 240 subjects with Alzheimer's disease ^ , ^ mild cognitive impairment 3 and elderly controls 4. Toga a , Paul M. Thompson a, 6 The Alzheimer's Disease Neuroimaging Initiative 7 a Laboratory of Neuro

  6. What can nonlinear dynamics teach us about the development of ventricular tachycardia/ventricular

    Physics Websites

    Otani, Niels F.

    limitations--the results can be difficult to translate into "English" and are only as good as the mathematical of APD on DI have come to be referred to as memory effects. These are dependences of the APD on earlier

  7. Numerical Analysis of Ca2+ Signaling in Rat Ventricular

    Mathematics Websites

    Holst, Michael J.

    of Bioengineering, University of California San Diego, La Jolla, California, United States of America, 2 Department of Medicine, University of California San Diego, La Jolla, California, United States of America, 4 Department of Mathematics, University of California San Diego, La Jolla, California, United States of America, 5 Department

  8. Estimation of 3D Left Ventricular Deformation from Echocardiography

    Biology and Medicine Websites

    Duncan, James S.

    . The general consensus is that the analysis of heart wall deformation provides quantitative estimates J. Sinusas 2,3 Donald P. Dione 3 and James S. Duncan 1,2 Yale Image Processing and Analysis Group 06520-8042. U.S.A. 4 Abstract The quantitative estimation of regional cardiac deformation from 3D image

  9. On two mechanisms of the domain structure of ventricular fibrillation

    Mathematics Websites

    Biktashev, Vadim N.

    the experimental study of fibrillation. This has revealed a high degree of spatio­temporal organisation­resolution maps, single site electrograms or the ECG. This contradiction requires a theoretical explanation

  10. Magnetic Design for the PediaFlow Ventricular Assist Device

    Engineering Websites

    Paden, Brad

    for energy transmis- sion; and 3 minimal blood damage. Figure 1 is an artistic rendering of the proposed VAD-dong, Yuseong-gu, Daejeon, Korea 305-764. E-mail: mnoh@cnu.ac.kr Artificial Organs 32(2):127­135, Blackwell P

  11. ORIGINAL RESEARCH Progressive right ventricular functional and structural

    Engineering Websites

    Chesler, Naomi C.

    of pulmonary arterial hypertension Zhijie Wang1 , David A. Schreier1 , Timothy A. Hacker2 & Naomi C. Chesler1.184 Abstract Right ventricle (RV) dysfunction occurs with progression of pulmonary arterial hypertension (PAH arterial hypertension (PAH) is the most severe form of pulmonary hypertension due to its rapid progression

  12. Blood damage measures for ventricular assist device modeling

    Materials Science Websites

    Natelson, Douglas

    of exposure. The distribution of the shear stress levels in a complex flow field of a rotary blood pump configuration guided only by the global, time- and space-averaged, indicators of the shear stress inside challenge that needs to be addressed in the design phase of blood pumps is the elevated level of shear

  13. Design and construction of a left ventricular cardiovascular assist device 

    Texas A&M University - TxSpace

    Vedi, Manmeet Singh

    2004-11-15

    pressures after careful consideration the Superpump Model SPS3891 available by Vivitro systems was chosen. Alternates to 21 the Vivitro system considered were low pressure tanks connected via a solenoid valve to the assist device. However... construction of such a device would be laborious and the setup for the experiment would have been bulky. Fig 6. Illustration of pressure pulse required 1. Super pump System (Model SPS3891:As provided by Vivitro systems) 2. High Volume...

  14. Rapid Ventricular Assessment Using Real-Time Interactive Multislice MRI

    Biology and Medicine Websites

    Southern California, University of

    myocardial perfusion defects in humans (6­8). Recently, using echo-planar imaging (EPI) acquisi- tions. Pauly,1 Dwight G. Nishimura,1 and Bob S. Hu2 A multislice real-time imaging technique is described which conditions. Three dynamically adjustable slices containing apical, mid, and base short axis views are imaged

  15. Powering a Ventricular Assist Device (VAD) With the

    Materials Science Websites

    Hochberg, Michael

    000 in the United States each year) than heart transplants. Previous transcutaneous energy transfer in range to a few milli- meters, do not tolerate angular misalignment, and suffer from poor efficiency

  16. Heart Rate Dynamics Before Spontaneous Onset of Ventricular

    Physics Websites

    Myocardial Infarcts Timo H. Ma¨kikallio, MD, MSc, Juhani Koistinen, MD, Luc Jordaens, MD, Mikko P. Tulppo myocardial infarction has been shown to be in- creased in patients with reduced heart rate (HR) vari- ability

  17. Flattening of the interventricular septum (D-shaped left ventricle) in addition to high right ventricular tracer uptake and increased right ventricular volume found on gated SPECT studies strongly correlates with right ventricular overload

    University of California eScholarship Repository

    Movahed, MD, PhD, FACC, FACP, FSCAI, FCCP, Mohammad-Reza R; Hepner, A; Lizotte, P; Milne, N

    2005-01-01

    99m Tc Myoview after stress (exercise in two, adenosine inis possible that exercise causes more stress toward alreadyexercise treadmill; one had dobutamine and 5 had adenosine infusion as a route of stress.

  18. Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

    University of California eScholarship Repository

    Yamazaki, Katrina Go

    2009-01-01

    medial sternotomy and left thoracotomy at the fifth intercostal space andmedial sternotomy and left thoracotomy at the fifth intercostal space andmedial sternotomy and left thoracotomy at the fifth intercostal space and

  19. A DYNAMIC PROGRAMMING SOLUTION TO TRACKING AND ELASTICALLY MATCHING LEFT VENTRICULAR WALLS IN CARDIAC CINE MRI

    Computer Technologies and Information Sciences Websites

    Tsaftaris, Sotirios

    Magnetic Resonance (MR) images is presented. For both tasks, dynamic programming (DP) is used. A mask con labeled by imaging experts. Index Terms-- Magnetic resonance imaging, detection, Dy- namic programming)-gated, short axis cine (cardiac phase- resolved) magnetic resonance images are acquired within a single breath

  20. Multi-Scale Modeling in Rodent Ventricular Myocytes: Contributions of structural and functional heterogeneities to

    Mathematics Websites

    Holst, Michael J.

    Department of Bioengineering, UCSD, La Jolla, CA 2 Department of Mathematics, UCSD, La Jolla, CA 3 Department and Imaging Research, UCSD, CA 6 Department of Medicine, UCSD, La Jolla, CA 7 Department of Bioengineering, finite element method Address for correspondence: Anushka Michailova, Ph.D. Department of Bioengineering

  1. Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes with Realistic Transverse Tubules

    Mathematics Websites

    Holst, Michael J.

    ; University of California San Diego, Bioengineering Holst, Michael; University of California, San Diego are with Department of Medicine, Department of Bioengineering, and Department of Mathematics and Physics, respectively

  2. Hyperbolic Ricci Flow and Geodesic Curve Lifting for Consistent Ventricular Surface

    Mathematics Websites

    Wang, Yalin

    University, AZ, USA 2 Department of Psychiatry and Psychology, Mayo Clinic Arizona, AZ, USA 3 Imaging Laboratory, Barrow Neurological Institute, AZ, USA 6 Department of Neurology, Mayo Clinic Arizona, AZ, USA over time could provide a more sensitive read of the clinical development of AD than the currently

  3. VENTRICULAR MAPS IN 804 SUBJECTS CORRELATE WITH COGNITIVE DECLINE, CSF PATHOLOGY, AND IMMINENT ALZHEIMER'S DISEASE

    Biology and Medicine Websites

    Thompson, Paul

    . Neurology, UCLA School of Medicine, Los Angeles, CA 2 Mayo Clinic, Rochester, MN; 3 Dept. Pathology of the ventricles, computed pointwise, was correlated with measures of (1) clinical decline, (2) pathology from CSF of brain MRI required 5-10 times fewer subjects than standard clinical measures to detect slowing of AD

  4. Three-dimensional organisation of re-entrant propagation during experimental ventricular brilation

    Mathematics Websites

    Biktashev, Vadim N.

    to be produced by the breakdown of re-entrant propagation waves of excitation into multiple re-entrant sources dimensional excitable media. Optically monitored, simultaneously recorded endo- cardial and epicardial of excitation has a domain organization. The domains are large (#25; 1 cm 2 ) and they persist for minutes. We

  5. Three dimensional aspects of re-entry in experimental and numerical models of ventricular

    Mathematics Websites

    Biktashev, Vadim N.

    of excitation into multiple re-entrant sources. These re-entrant waves may be idealised as spiral waves in two dimensional, and scroll waves in three dimensional excitable media. Optically monitored, simultaneously waves. We show that numerical simulations, even with a simple homogeneous excitable medium, can

  6. Three dimensional aspects of reentry in experimental and numerical models of ventricular

    Mathematics Websites

    Biktashev, Vadim N.

    waves of excitation into multiple re­entrant sources. These re­entrant waves may be idealised as spiral waves in two dimensional, and scroll waves in three dimensional excitable media. Optically monitored show spiral waves. We show that numerical simulations, even with a simple homogeneous excitable medium

  7. Triggered alternans in an ionic model of ischemic cardiac ventricular muscle

    Biology and Medicine Websites

    Guevara, Michael R.

    Osler Promenade, Montre´al, Que´bec H3G 1Y6, Canada Received 4 March 2002; accepted 19 June 2002-timed extrastimulus. Using a stimulation protocol involving delivery of pre- and post-mature stimuli, we derive a one

  8. MicroRNA analysis of human embryonic stem cell derived cardiomyocytes and neonatal rat ventricular cardiomyocytes

    University of California eScholarship Repository

    Nelson, Brandon John

    2007-01-01

    Embryonic Stem Cells via Downregulation of Notch1 Signaling. Circulation Research,research effort to develop the means to replace the damaged or dead cardiomyocytes with transplanted cells, such as human Embryonic Stem

  9. Atlas Generation for Subcortical and Ventricular Structures With Its Applications in Shape Analysis

    MIT - DSpace

    Qiu, Anqi

    Atlas-driven morphometric analysis has received great attention for studying anatomical shape variation across clinical populations in neuroimaging research as it provides a local coordinate representation for understanding ...

  10. MULTIVARIATE TENSOR-BASED MORPHOMETRY ON SURFACES: APPLICATION TO MAPPING VENTRICULAR CHANGES IN HIV/AIDS

    Mathematics Websites

    Wang, Yalin

    of brain images to infer local differences in brain volume or shape. Tensor-based morphometry (TBM) [5, 6 for Mathematics & Physical Sciences. or vorticity. One advantage of TBM is that it derives local derivatives with significant group differences or changes over time. In this pa- per, we pursue the notion that TBM can even

  11. Hippocampal and Ventricular Differences in 804 ADNI subjects mapped with Multivariate Tensor-Based Morphometry

    Biology and Medicine Websites

    Thompson, Paul

    p-map based on three different local statistics: multivariate TBM, Jacobian determinant and distance, but multivariate TBM gave greatest effect sizes (as shown in the cumulative distribution plots of p- values; Figure in AD versus MCI, using the same 3 statistics. Again, multivariate TBM gave greatest effect sizes

  12. De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy

    Materials Science Websites

    Bielefeld, Universität

    ) is an inherited heart muscle disease, frequently accompanied by sudden cardiac death and terminal heart failure in the desmosomal candidate genes JUP, DSG2, DSC2, DSP and PKP2 known to be associated with ARVC. In 43% of the cohort, we found disease- associated sequence variants. In addition, we screened for desmin mutations

  13. Dynamic Stresses and Strains in the Left Ventricular Wall based on Large Deformation

    Mathematics Websites

    Bukiet, Bruce

    and demand. For example, as stresses increase, strain energy increases, resulting in an increase in the energy and consequently oxygen demand [1]. The increased stresses also reduce the oxygen supply by collapsing the intraventricular arteries and thus causing flow resistance [2]. In addition, an increase

  14. Quantitative localization of premature ventricular contractions using myocardial activation ECGI from the standard 12-lead electrocardiogram

    University of California eScholarship Repository

    Van Dam, PM; Tung, R; Shivkumar, K; Laks, M

    2013-01-01

    the 12-lead ECG. In this feasibility study, the accuratestudy of a novel myocardial activation-based ECGI using only the standard 12-lead ECGECGs). 5 To better understand the mathematical models used in this study,

  15. Feature selection using support vector machines and bootstrap methods for ventricular fibrillation detection

    Computer Technologies and Information Sciences Websites

    Camps-Valls, Gustavo

    the surface electrocardiogram (ECG), showing always a lim- ited performance. The combination ECG parameters machine learning schemes has raised the need of efficient feature selection (FS) procedures. In this study to a nonparametric statistic based on BR. After simulation studies, we benchmark the performance of our FS algorithm

  16. Temporal evolution for the phase histogram of ECG during human ventricular fibrillation

    Physics Websites

    , and fibrillation is manifested as irregular electrical activity of the heart. During fibrillation the coordinated contraction of the cardiac muscle is lost and the mechanical pumping effectiveness of the heart fails

  17. Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support

    University of California eScholarship Repository

    2014-01-01

    natriuretic peptide levels show a downward trend. In addition, ?-adrenergic receptornatriuretic peptide; Erk, extracellular signal-regulated kinases; FGF, fibroblast growth factor; GSK-3?, glycogen synthase kinase-3?; Her2/neu, human epidermal growth factor receptor

  18. Artificial muscle technology applied towards treating ischemic mitral regurgitation caused by left ventricular remodeling

    MIT - DSpace

    Sabourin, Nicaulas A. (Nicaulas Alexandre), 1978-

    2004-01-01

    Ischemic Mitral Regurgitation (MR) affects a large portion of patients suffering from ischemic heart disease. Significant MR develops in one quarter to one third of patients who suffer from ischemic heart disease and doubles ...

  19. Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models.

    Biology and Medicine Websites

    Duncan, James S.

    outside their usual line of work. I would also like to acknowledge the support and help from Peter Belhumeur and David Kriegman, especially during my first two years at Yale. Thanks also to Peter Schultheis. This would not have been possible without the cooperation of a number of individuals which the author would

  20. Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models

    Biology and Medicine Websites

    Duncan, James S.

    problems outside their usual line of work. I would also like to acknowledge the support and help from Peter Belhumeur and David Kriegman, espe- cially during my first two years at Yale. Thanks also to Peter- lar image sequences. This would not have been pos- sible without the cooperation of a number

  1. A NEW AUTOMATED TECHNIQUE FOR LEFT-AND RIGHT-VENTRICULAR SEGMENTATION IN MAGNETIC RESONANCE IMAGING

    Biology and Medicine Websites

    Konofagou, Elisa E.

    , the edge detection is performed and the papillary muscles (PMs) are excluded via a convex-hull method with morphological operations. The algorithm extracts the most precise myocardial and RV contours. Experimental the error between the target and the synthesized image. In segmentation, all aforementioned algorithms have

  2. Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function in Dogs

    Engineering Websites

    Chesler, Naomi C.

    ) Associate Editor Ender A. Finol oversaw the review of this article. Abstract--Pulmonary hypertension (PH by noninvasive methods may be possible. Keywords--Pulmonary arterial hypertension, PAH, Ventric- ular hypertension (PAH) is a devas- tating disease exhibiting fast progression14 and poor prognosis.20,26 PAH

  3. Methods for Measuring Right Ventricular Function and Hemodynamic Coupling with the Pulmonary Vasculature

    Engineering Websites

    Chesler, Naomi C.

    application of these methods to RV function and coupling changes with pulmonary hypertension. We especially dysfunction, Mechanical efficiency, Metabolic efficiency, Pulmonary circulation, Pulmonary hypertension, such as pulmonary arterial hypertension (PAH) compromise RV function, in particular its ability to increase

  4. Differences Between Left and Right Ventricular Chamber Geometry Affect Cardiac Vulnerability to Electric Shocks

    Engineering Websites

    encompassing episodes of arrhythmia induction. For RV­ shocks, VA was nearly rectangular indicating little dependence of postshock arrhythmogenesis on CI. For LV­ shocks, the probability of arrhythmia induction area; arrhythmia induction Defibrillation and cardiac vulnerability to electric shocks are strongly

  5. BioSystems 71 (2003) 7180 Reentrant waves in a ring of embryonic chick ventricular cells

    Biology and Medicine Websites

    Glass, Leon

    2003-01-01

    , reentrant cardiac arrhythmias may be associated with waves circulating in a ring geometry. This study arrhythmias; Reentrant tachycardia; Pacemakers; Refractory period; Overdrive suppression; Unidirectional block 1. Introduction Reentrant rhythms are widely implicated in life- threatening cardiac arrhythmias

  6. Discordant Calcium Transient and Action Potential Alternans in a Canine Left-Ventricular Myocyte

    MIT - DSpace

    Armoundas, Antonis A.

    Electrocardiographic alternans is known to predispose to increased susceptibility to life threatening arrhythmias and sudden cardiac death. While this decreased level of cardiac electrical stability is often due to the ...

  7. Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy

    Engineering Websites

    of a narrow catalog of the functionally most important genes regulating ion homeostasis. We focused, the gene crucial for Na+ and K+ homeostasis. Thus, our cell- specific molecular profiling defined new with Ca2+ homeostasis and energy metabolism. However, some of the implicated genes may be secondary to ICM

  8. Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

    University of California eScholarship Repository

    Yamazaki, Katrina Go

    2009-01-01

    CA. 7. K. Go. Abnormal cardiac wall motion and early matrixGo KV, Covell JW, Villarreal FJ. Abnormal cardiac wall motion and early matrixGo KV, Covell JW, Villarreal FJ. Abnormal cardiac wall motion and early matrix

  9. Modeling, Estimation and Control of Cardiovascular Systems with A Left Ventricular Assist Device

    Engineering Websites

    Wu, Yi

    to approximate the response of human cardiovascular circulatory system. This system model has one critical time as test environments for human cardiovascular circulatory systems with a left ventric- ular assist device patient are restored back to the normal physiologic range. Keywords: Cardiovascular circulatory system

  10. Normal and Hydrocephalic Brain Dynamics: The Role of Reduced Cerebrospinal Fluid Reabsorption in Ventricular Enlargement

    Engineering Websites

    Linninger, Andreas A.

    be nec- essary in explaining diseases of the central nervous system such as hydrocephalus, Chiari-spinal system. Computed velocities agree closely with our in vivo CINE-MRI CSF flow measurements. In addition transmantle pressure gradients. Keywords--Cerebrospinalfluid,Computationalfluiddynamics, Fluid­structure

  11. Finding Hidden Patterns in Complex Ventricular Ectopy V Schulte-Frohlinde

    Environmental Management and Restoration Websites

    Ashkenazy, Yossi "Yosef"

    Studies and Department of Physics, Boston University, Boston, USA£ Department of Physics, Harvard hours using a temporal reorganization of the data. Our three dimensional rate-dependent histograms show

  12. Original Research Article Estimation of right atrial and ventricular hemodynamics by

    Engineering Websites

    Mittal, Rajat

    , * a Department of Medicine, George Washington University School of Medicine and Health Sciences, 2150 of Medicine and Health Sciences, Washington, DC, USA KEYWORDS: CT coronary angiography; Hemodynamics alternative to the invasive assessment of coronary artery disease. However, a specific limitation of CTCA

  13. Stresses and Strains in the Left Ventricular Wall Approximated as a Thick Conical Shell

    Mathematics Websites

    Bukiet, Bruce

    Deformation Theory H. R. Chaudhry Department of Physical Medicine and Rehabilitation UMDNJ­New Jersey Medical and Rehabilitation UMDNJ­New Jersey Medical School Newark, NJ 07102 and Department of Physical Medicine and Rehabilitation East Orange VA Medical Center East Orange, NJ (send all correspondence to B. Bukiet, Tel: (201

  14. PointTracked Quantitative Analysis of Left Ventricular Motion from 3D Image Sequences

    Biology and Medicine Websites

    Duncan, James S.

    in overestimation of true myocardial infarction. More sophisticated quantitative analysis of myocardial dynamics may of the remodeling process following myocardial infarction as it relates to the extent of myocardial injury motion parameters (path length and thickness changes) in detecting myocardial injury is tested

  15. Lidocaine Toxicity Misinterpreted as a Stroke

    University of California eScholarship Repository

    Bursell, Benjamin; Smally, Alan J; Ratzan, Richard M

    2009-01-01

    lidocaine has been used to treat ventricular arrhythmias.lidocaine bolus and drip successfully abolished ventricular arrhythmiaslidocaine has been administered for the treatment of ventricular arrhythmias

  16. 48 Am J Psychiatry 157:1, January 2000 Large CSF Volume Not Attributable to Ventricular Volume

    Biology and Medicine Websites

    in Schizotypal Personality Disorder Chandlee C. Dickey, M.D., Martha E. Shenton, Ph.D., Yoshio Hirayasu, M.D., Ph whether schizotypal personality disorder, which has the same genetic diathesis as schizophrenia, manifests with schizotypal personality disorder were recruited from the community and were age-matched to 14 healthy

  17. Phase statistics approach to human ventricular fibrillation Ming-Chya Wu,1,2,3,* Eiichi Watanabe,4,

    Physics Websites

    VF is known to be the most dangerous cardiac arrhythmia, frequently leading to sudden cardiac death SCD . During VF, cardiac output drops to nil and, unless the fibrillation is promptly halted, death. Sudden cardiac death SCD is both a leading and a grow- ing cause of death in the industrialized world

  18. Two forms of spiral-wave reentry in an ionic model of ischemic ventricular Aoxiang Xu and Michael R. Guevara

    Biology and Medicine Websites

    Guevara, Michael R.

    , McGill University, 3655 Drummond Street, Montre´al, Que´bec, H3G 1Y6 Canada Received 28 July 1997 is induced using a pacing protocol in which the pacing frequency is gradually increased. When K o protocol is changed by adding two additional stimuli, a type I spiral wave is instead produced at K ]o 10

  19. The accompanying paper (Vaughan-Jones et al. 2002) reported that, in rabbit ventricular myocytes, the apparent

    Biology and Medicine Websites

    Keener, James P.

    , the apparent diffusion coefficient for the intracellular H+ ion (DH app) or its ionic equivalent such as OH inorganic ions like Na+ or K+ . This value of DH app represents the intrinsic mobility of H+ equivalents-Jones et al. 2002). If this model of H^ equivalent mobility is correct, adding a more mobile buffer

  20. THE FUNCTIONAL ROLES OF THE LATERAL PYLORIC AND VENTRICULAR DILATOR NEURONS IN THE PYLORIC NETWORK OF THE LOBSTER,

    Biology and Medicine Websites

    Weaver, Adam Lee

    There are several people who were instrumental in this work. First, I would like to thank my family (Russell & Linda, as well as providing a venue for constructive criticism of my presentations. Also, financial support from

  1. QUANTITATIVE GENETIC MODELING OF LATERAL VENTRICULAR SHAPE AND VOLUME USING MULTI-ATLAS FLUID IMAGE ALIGNMENT IN TWINS

    Biology and Medicine Websites

    Thompson, Paul

    Major efforts in computational anatomy have analyzed statistical variations in neuroanatomy in large factors affecting disease progression and its cognitive correlates. Computational anatomy has been successful in encoding the 3D pattern of normal variations in anatomy, but their genetic or environmental

  2. Evaluation of external ventricular drain complications and the use of a procedure-targeted image-guidance system

    MIT - DSpace

    Patil, Vaibhav Devidas

    2011-01-01

    Access to the cerebral ventricle (e.g. ventriculostomy) is required to manage multiple life-threatening ailments. It can be done either in the operating room or at the bedside to relieve increased intracranial pressure or ...

  3. Multiple levels of the single L-type Ca2+ channel conductance in adult mammalian ventricular myocytes

    Engineering Websites

    Chen-Izu, Ye

    the ryanodine receptor, causing muscle contraction. This Ca2+ induced Ca2+ release (CICR) is locally controlled; conductance; Ca2+; excitation-contraction coupling INTRODUCTION In cardiac muscle, Ca2+ entry through L muscle contraction. This Ca2+ induced Ca2+ release (CICR) is locally controlled by the opening of single

  4. Differences in the Cerebral Hemodynamics Regulation Mechanisms of Premature Infants with Intra-Ventricular Hemorrhage Assessed by

    Engineering Websites

    hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (r

  5. Quantification of Left Ventricular Regional Phase Asynchrony in Patients with Left Bundle Branch Block Using Tissue Doppler Echocardiography

    Engineering Websites

    Stetten, George

    in heart failure pts with LBBB, however methods to quantify asynchrony are limited. To test the hypothesis that tissue Doppler (TD) can quantify LV asynchrony, 17 pts with LBBB (11 with heart failure) and 10 normal Gorcsan III, University of Pittsburgh, Pittsburgh, PA American Heart Association Scientific Sessions, 2000

  6. Effects of Protein Phosphatase and Kinase Inhibitors on Ca2 and Cl Currents in Guinea Pig Ventricular Myocytes

    Biology and Medicine Websites

    Effects of Protein Phosphatase and Kinase Inhibitors on Ca2 and Cl Currents in Guinea Pig of this study was to compare the effects of various protein phosphatase and protein kinase inhibitors, it is not clear whether both of these channels are regulated in concert by protein kinase A (PKA) or whether

  7. A Virtual Endoscopy System for the Planning of Endoscopic Interventions in the Ventricular System inside of the Human

    Computer Technologies and Information Sciences Websites

    Bartz, Dirk

    Duffnerc aComputer Graphics Lab University of T¨ubingen bDepartment of Neuroradiology University Hospital T interventions in neurosurgery is based on the thorough examination of slice images of a MRI scan. In cooperation methods for examination and planning. In our approach, this step consists of two stages; a preprocessing

  8. 320 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 56, NO. 2, FEBRUARY 2009 CPR Artifact Removal in Ventricular Fibrillation

    Mathematics Websites

    Feichtinger, Hans Georg

    and compared to two well-established CPR removal algorithms that use an adaptive filtering system and a state circulatory state, and therefore, worsens the chance for a suc- cessful defibrillation [3], [4]. ECG analysis

  9. Abstract--Today, echocardiography is regarded as the clinical gold standard for evaluation of left ventricular (LV)

    Biology and Medicine Websites

    prognostic indicators after a myocardial infarct [1], but WMSI is derived solely from subjective visual index are subject to significant inter-observer variability. Ultrasound- based measures of myocardial on the meaning, interpretation, and normal ranges of myocardial strain is still lacking, thus preventing routine

  10. Phenotyping transgenic embryonic murine hearts using optical coherence tomography

    Biotechnology Websites

    to obtain cavity volumes and wall thicknesses. The mutant hearts exhibited increased ventricular chamber, thin ventricular walls, and increased size of the ventricular cavities.4,5 These findings suggest HEXIM

  11. CONTRAST AGENT-INDUCED CARDIAC ARRHYTHMIAS IN RATS James F. Zachary

    Engineering Websites

    Illinois at Urbana-Champaign, University of

    echogenic contrast imaging agents (MUECIA) in the United States, premature ventricular contractions have including heart disease and cancer. Premature ventricular contractions/complexes have been reported

  12. Elec 331 -EKG, EEG & EMG Definitions

    Energy Storage, Conversion and Utilization Websites

    Pulfrey, David L.

    ) of electrical (electro) heart activity (cardio) ­ EKG · Germanic ­ ECG · Romantic · Lead ­ Voltage measurement ­ Ventricular depolarization · T Wave ­ Ventricular repolarization · Bandwidth 150Hz (American Heart Assoc

  13. Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

    University of Cambridge - Dspace

    Hermes, Gretchen; Ajioka, James W.; Kelly, Krystyna A.; Mui, Ernest; Roberts, Fiona; Kasza, Kristen; Mayr, Thomas; Kirisits, Michael J.; Wollman, Robert; Ferguson, David J. P.; Roberts, Craig W.; Hwang, Jong-Hee; Trendler, Toria; Kennan, Richard P.; Suzuki, Yasuhiro; Reardon, Catherine; Hickey, Adam William; Chen, Lieping; McLeod, Rima

    2008-10-23

    and quantitated using a spectrophotometer (260 lamba). The extinction coefficient aliquots of 40 ?g (260/ 280 was less than 1.6) were utilized for hybridization For hybridization experiments 40 ?g total RNA was mixed with a 17 mer dT oligo (Sigma) and reverse...

  14. Abstract--Two semi-automatic methods for the detection of the left ventricular border in two-dimensional short axis

    Engineering Websites

    Carvalho, João Luiz

    for the assessment of myocardial function requires the identification of the left ventricle walls. Some clinical, a motion detection procedure is used for rejecting frames with movement. In the second method, the frame of the described algorithm. The first step consists of the detection and rejection of frames with movement. Sets

  15. V.N. Biktashev & A.V. Holden ``Reentrant activity and its control by resonant drift in a twodimensional model of isotropic homogeneous ventricular tissue'' Proc Roy Soc

    Mathematics Websites

    Biktashev, Vadim N.

    NaK + I Na + I bNa + I siNa + I NaCa + I siCa + I bCa ) â?? m = 200(V + 41) 1 \\Gamma exp [\\Gamma0:1(V siCa + I bCa \\Gamma 2I NaCa ) \\Gamma I up + I rel V SRup V rel V i V up \\Gamma d dt [Ca 2+ ] calmod = (1 \\Gamma f act \\Gamma f prod )(500( [Ca 2+ ] i [Ca 2+ ] i + kmCa `(I siCa ) ) 2 ) \\Gammaf act (500

  16. Hysteresis and bistability in the direct transition from 1:1 to 2:1 rhythm in periodically driven single ventricular cells

    Biology and Medicine Websites

    Guevara, Michael R.

    in the experiments as in the model. Finally, we point out a few implications of our findings for cardiac arrhythmias in the intact heart, one of a variety of abnormal cardiac arrhythmias can arise. In single quies- cent cells

  17. Finding Hidden Patterns in Complex Ventricular Ectopy V Schulte-Frohlinde'i2,Y Ashkenazy', PCh Ivanov'13, A Morley-Davies4,L Glass5,

    Materials Science Websites

    Stanley, H. Eugene

    of a patient with congestive heart failure (subject 2 in the following figures). The upper panel shows 8000 in subjects with congestive heart failure. In the RR-time series they appear in complex patterns that often We analyze a data set of RR-time series of 200 subjects with congestive heart failure. Out

  18. Journal of Theoretical Biology 249 (2007) 2945 Rhythms of high-grade block in an ionic model of a strand of regionally

    Biology and Medicine Websites

    Guevara, Michael R.

    2007-01-01

    , and is often immediately followed by malignant cardiac arrhythmias such as ventricular tachycardia of regionally ischemic ventricular muscle. In addition, in the experimental work, ventricular arrhythmias on the higher-order rhythms that presage reentrant ischemic ventricular arrhythmias. r 2007 Elsevier Ltd. All

  19. BANDO DI SELEZIONE PER IL CONFERIMENTO DI 1 ASSEGNO PER LA COLLABORAZIONE AD ATTIVITA' DI RICERCA

    Computer Technologies and Information Sciences Websites

    Di Pillo, Gianni

    in left ventricular assist device (LVAD) and autologous stem cell combined therapy in left ventricular assist device (LVAD) and autologous stem cell combined therapy (LVAD) e cellule staminali autologhe" ­ "Boosting cardiac regeneration: breakthrough

  20. Automated Axial Right Ventricle to Left Ventricle Diameter Ratio Computation in Computed Tomography Pulmonary Angiography

    MIT - DSpace

    Kumamaru, Kanako K.

    Right Ventricular to Left Ventricular (RV/LV) diameter ratio has been shown to be a prognostic biomarker for patients suffering from acute Pulmonary Embolism (PE). While Computed Tomography Pulmonary ...

  1. Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations in cardiovascular function

    Engineering Websites

    Chesler, Naomi C.

    Mitochondria DNA mutations cause sex-dependent development of hypertension and alterations Article history: Accepted 19 December 2014 Keywords: Hemodynamics Elastic modulus Hypertension Ventricular factor for and can precede hypertension and ventricular dysfunction. Increases in mitochondria DNA (mt

  2. Common variants at ten loci modulate the QT interval duration in the QTSCD Study

    Mathematics Websites

    Abecasis, Goncalo

    interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD

  3. Multi-Variate Visualization of Cardiac Virtual Tissue J W Handley

    Computer Technologies and Information Sciences Websites

    Brodlie, Ken

    state of a 2D cardiac virtual tissue. 1 Introduction Cardiac arrhythmias associated with heart disease and sustain the lethal arrhythmias of ventricular fib- rillation (VF) and ventricular tachycardia (VT) remain

  4. Development/Plasticity/Repair Serotonergic Neurons Migrate Radially through the

    Biotechnology Websites

    44106 Embryonic CNS neurons can migrate from the ventricular zone to their final destination by radial and Moore, 1978; Wallace and Lauder, 1983), serotonergic neuron migration from the ventricular zone

  5. Measurement of Normal Vectors of the Left Ventricle from Segmented MRI: Comparison of four Practical Methods

    Computer Technologies and Information Sciences Websites

    Rachidi, Tajje-eddine

    and following myocardial infarction. 2 Previous work The use of shape for describing 3-D objects has re- ceived ventricular function and myocardial viability 4, 6, 7, 9, 10, 11, 12] based on the evaluation of ventricular

  6. Third Report of the California Hospital Outcomes Project (1997): Report on Heart Attack, 1991-1993 Volume 2

    University of California eScholarship Repository

    Romano, Patrick S; Luft, Harold S; Rainwater, Julie A

    1997-01-01

    lung, unspecified Pulmonary insufficiency following traumafailure Other pulmonary insufficiency, not elsewherepulmonary edema, paroxysmal ventricular tachycardia, sepsis, shock, and vascular insufficiency.

  7. CARDIAC ARRHYTHMIA CLASSIFICATION USING SUPPORT VECTOR MACHINES

    Computer Technologies and Information Sciences Websites

    Voglis, Costas

    ) premature ventricular contractions, (3) normal sinus rhythm and (4) 2o heart block. The MIT-BIH arrhythmia are classified: (1) beats belonging to ventricular flutter/fibrillation episodes, (2) premature ventricular contractions, (3) normal sinus rhythm and (4) beats belonging to 2o heart block episodes. The method

  8. Dynamics of pure parasystole LEON GLASS, ARY L. GOLDBERGER, AND JACQUES BELAIR

    Biology and Medicine Websites

    Glass, Leon

    new approaches to assessing the mechanism of com- plex ventricular arrhythmias. ventricular cardiac arrhythmia; number theory; cardiac oscil- lator VENTRICULAR ARRHYTHMIAS are of major clinical impor- tance parasystole is a cardiac arrhythmia char- acterized by three distinctive features on the electrocar- diogram

  9. A New Class of Antiarrhythmic-Defibrillatory Agents Ofra Levy,a

    Chemistry Websites

    Keinan, Ehud

    - tricular arrhythmia, such as ventricular tachycardia and ventricular fibrillation (VF), plays the major efforts to decrease the incidence of ventricular arrhythmia that might end in VF.6 Unfortunately, since VF Arrhythmia Suppression Trial, CAST I and II,8,9 have clearly demonstrated the limitations of this therapeutic

  10. Schizophrenia Research, 5 (1991) 1033113 SCHIZO 00172

    Biology and Medicine Websites

    1991-01-01

    volumetric measurement techniques to the ventricular system in schizophrenics and normal controls* Martha E of these data sets into volumetric information and 3D display, we examined the ventricular system in a sample no significant differences were noted between groups on volumetric measures of ventricular brain ratio or lateral

  11. Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillationa...

    Mathematics Websites

    Mascia, Corrado

    August 1997; accepted for publication 21 November 1997 Wave propagation in ventricular muscle is rendered in a parallelepipedal slab of ventricular muscle of varying wall thickness (S) and fiber rotation rate ( z). The main contraction of the ventricular muscle and its main pumping function. Progress to date has led to the plausible

  12. V.N. Biktashev & A.V. Holden "Re-entrant activity and its control by resonant drift in a two-dimensional model of isotropic homogeneous ventricular tissue" Proc Roy Soc

    Mathematics Websites

    Biktashev, Vadim N.

    + IsiK + IbK + INaK + INa + IbNa + IsiNa + INaCa + IsiCa + IbCa) m = 200(V + 41) 1 - exp [-0.1(V + 41Na [Na+ ]o 140 + 3INaK + 3INaCa + IsiNa) [K+]i = -1 ViF (IK + IK1 + IsiK + IbK + Ito - 2INaK) [Ca2+ ]i = -1 2ViF (IsiCa + IbCa - 2INaCa) - Iup + Irel VSRupVrel ViVup - d dt [Ca2+ ]calmod - d dt [Ca2+ ]trop

  13. Please cite this article in press as: Linninger A, et al. An impedance sensor to monitor and control cerebral ventricular volume. Med Eng Phys (2009), doi:10.1016/j.medengphy.2009.03.011

    Engineering Websites

    Linninger, Andreas A.

    2009-01-01

    of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, United States b Department of Neurosurgery, University of Chicago, Chicago, IL 60637, United States a r t i c l e i n f o Article history: Received 24 S Morgan St, Chicago, IL 60607, United States. Tel.: +1 312 413 7743. E-mail address: linninge@uic.edu (A

  14. 3D Mapping of the Lateral Ventricles in Autism Christine N. Vidal MS, 4

    Biology and Medicine Websites

    Thompson, Paul

    , visualized in the average anatomical maps, were assessed using surface- based nonparametric regression volumes. Group differences in ventricular volumes were assessed with multivariate regression. Results

  15. doi:10.1152/ajpheart.01400.2007 294:1753-1766, 2008. First published Feb 8, 2008;Am J Physiol Heart Circ Physiol

    Engineering Websites

    MacLeod, Rob S.

    -duration ventricular fibrillation in dogs Chemical ablation of the Purkinje system causes early termination (monthly) by the American lymphatics, including experimental and theoretical studies of cardiovascular

  16. Reprint from J.L. Wu, K. Ito, S. Tobimatsu, T. Nishida, H. Fukuyama (Eds.)

    Computer Technologies and Information Sciences Websites

    Igarashi, Takeo

    . Introduction To better understand the mechanisms of fatal arrhythmias, we had previ- ously developed, and also had visualized the various elec- trophysiological phenomena of arrhythmias in our ventricular

  17. Central Nervous System Myelination in Mice With Deficient Expression of Notch1

    Biology and Medicine Websites

    Bongarzone, Ernesto R.

    ; Delta1 Oligodendrocyte progenitor cells (OPCs) emerge from the ventricular and subventricular zones a considerable proliferative capacity, which appears to be exhausted once they enter the terminal stages

  18. SELECTION PROCEDURE No. 1/2013 SAPIENZA UNIVERSITY OF ROME

    Computer Technologies and Information Sciences Websites

    Di Pillo, Gianni

    regeneration: breakthrough in left ventricular assist device (VAD) and autologous stem cell combined therapy" Interview: "State of the art in the use of ventricular assist device (VAD) and cardiac stem cell therapies therapy and tissue engineering in cardiovascular diseases" Interview: "Limbal and mesenchimal stem cells

  19. 1450 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 58, NO. 5, MAY 2011 Dynamic Brain Phantom for Intracranial

    Engineering Websites

    Linninger, Andreas A.

    , we present a model that emulates the expansion of the lateral ventricles seen in hydrocephalus THE VENTRICULAR system of the brain is composed of two lateral ventricles, one in each of the hemispheres such as hydrocephalus, the ventricular spaces may expand dras- tically. The lateral ventricles undergo the largest

  20. 1532 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 59, NO. 6, JUNE 2012 Phantom Model of Physiologic Intracranial Pressure

    Materials Science Websites

    Daraio, Chiara

    nervous system (CNS). Within the intracranial cavity, CSF is confined in the ventricular and sub of the modeled dynamics. Index Terms--Anatomical model, compliance, subarachnoid space (SAS), ventricular system metabolic waste products. Alteration in CSF dynamics relates to several disorders. Hy- drocephalus

  1. Model-driven deformable atlases 1083 Figure 17.5: Partitioning the ventricles into 3D surface elements. A model of the lateral

    Biology and Medicine Websites

    Thompson, Paul

    and a smoothed cortical surface mesh. The ventricles are partitioned into 14 connected surface elements, whose junctions reflect tissue type boundaries at the ventricular surface. For example, caudate, thalamic, and septal tissues (as well as callosal fibers) surround the superior ventricular horn, and each exhibits

  2. PRAMANA c Indian Academy of Sciences Vol. 64, No. 4 --journal of April 2005

    Physics Websites

    Sinha, Sitabhra

    ­562 Death, dynamics and disorder: Terminating reentry in excitable media by dynamically, such as ventricular tachycardia, often leading to death. This is typically treated by rapid stimula- tion from to lethal ventricular fibrillation (VF), leading to death within minutes if no immediate action is taken

  3. Physica 7D (1983) 89-101 North-Holland Publishing Company

    Biology and Medicine Websites

    Guevara, Michael R.

    1983-01-01

    contraction. Fig. IA shows a normal ECG. In a class of disorders called the atrioventricular(AV) heart blocks block the delay between the atrial and ventricular con- tractions is elevated above its normal maximal value. In second degree AV block, atrial con- tractions are not always followed by ventricular

  4. University of California Year 2007 Paper 3189

    Computer Technologies and Information Sciences Websites

    expansion in the Cardiovascular Health Study. Owen T Carmichael, L H Kuller, O L Lopez, P M Thompson, R, "Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study." (2007). Neurobiology://repositories.cdlib.org/postprints/3189 #12;Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study. Abstract

  5. David Schreier Department of Biomedical Engineering,

    Engineering Websites

    Chesler, Naomi C.

    53706 e-mail: chesler@engr.wisc.edu The Role of Collagen Synthesis in Ventricular and Vascular in PAH is proximal pulmonary artery stiffening, which is mediated by collagen accumulation in hypoxia and ventricular collagen accumulation on RV function and the hemodynamic coupling efficiency between the RV

  6. 4D Cardiac Reconstruction Using High Resolution CT Images

    Computer Technologies and Information Sciences Websites

    Huang, Junzhou

    , such as the papillary muscles and the ventricular trabeculae, for the first time, which allows us to quan- titatively high and increasing rates of cardiovascular diseases. There- fore, it is critical to detect structures, such as the papillary muscles, the ventricular trabeculae and the valves, are often difficult

  7. Luo W, Gallagher M, Wiles J. Parameter-free search of time-series discord. JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY 28(2): 300310 Mar. 2013. DOI 10.1007/s11390-013-1330-8

    Computer Technologies and Information Sciences Websites

    Gallagher, Marcus

    segment for a patient with premature ventricular contraction arrhythmia. The anomalous subsequence circled ventricular contraction arrhythmia[13] . The presence of arrhythmia is reflected in the time series discord applications[9-12] . For example, Fig.1 shows an electrocardiography (ECG) recording used to detect premature

  8. BIOGRAPHICAL SKETCH Skliar, Mikhail

    Engineering Websites

    Skliar, Mikhail

    with Implantable Rotary Blood Pumps," Artificial Organs, 27:639-648, 2003. 11. G. Giridharan and M. Skliar, "Non for Ventricular Assist Devices," Artificial Organs, 26:980-984, 2002. 5. D. Arora, M. Skliar, R. B. Roemer, "Model-Linear Controller for Ventricular Assist Devices," Artificial Organs, #12;26:980-984, 2002. 12. Y.-H. Choi and M

  9. Creation of Transcatheter Aortopulmonary and Cavopulmonary Shunts Using Magnetic Catheters: Feasibility Study in Swine

    University of California eScholarship Repository

    2009-01-01

    perforation of the right ventricular out?ow tract as a palliative strategy for pulmonary atresia with ventricular septalperforation from the SVC to the right pulmonary artery was accomplished with a trans- septalperforation. Thus, a ‘‘balloon-target’’ method was used to guide trans-septal

  10. Prevalence of symptoms and diagnoses for patients suspected of having congenital heart disease

    Mathematics Websites

    Serfling, Robert

    .10 0.20 0.70 Y1 = normal Y2 = atrial septal defect without pulmonary stenosis or pulmonary hypertension Y5 = transposed great vessels Y6 = ventricular septal defect without pulmonary hypertension Y7 = ventricular septal defect with pulmonary hypertension X1 = age 1-20 years old X2 = age > 20 years old X3

  11. O R I G I N A L R E S E A R C H What does the time constant of the pulmonary circulation

    Engineering Websites

    Chesler, Naomi C.

    about the progression of right ventricular dysfunction in pulmonary arterial hypertension? A. Bellofiore hypertension (PAH). However, little is known about the dependence of right ventricular (RV) function arterial hypertension (PAH), a key knowledge gap is the mechanisms that underlie the transition from normal

  12. Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization

    Physics Websites

    Gauthier, Daniel

    , to the genesis of lethal arrhythmias such as ventricular fibrillation. Prior studies have considered various APD , to the genesis of lethal cardiac arrhythmias such as ventricular fibrillation. Such findings been linked to the onset of potentially fatal arrhythmias, it is desirable to suppress alternans

  13. 97:377-383, 2004. doi:10.1152/japplphysiol.01235.2001J Appl Physiol Kevin Kit Parker, James A. Lavelle, L. Katherine Taylor, Zifa Wang and David E.

    Materials Science Websites

    Parker, Kevin Kit

    . Garcia-Dorado, L. Agullo, A. Rodriguez-Sinovas, F. Padilla, L. Trobo and J. ventricular arrhythmias after://highwire.stanford.edu/lists/artbytopic.dtlcan be found atMedline items on this article's topics Medicine .. Ischemia Medicine .. Arrhythmia Physiology.physiology.orgDownloadedfrom #12;TRANSLATIONAL PHYSIOLOGY Stretch-induced ventricular arrhythmias during acute ischemia

  14. Model Based Visualization of Cardiac Virtual Tissue J W Handley, K W Brodlie, R H Clayton

    Computer Technologies and Information Sciences Websites

    Brodlie, Ken

    arrhythmias such as this are an important cause of premature death in the industrialised world, yet the mechanisms that initiate and sustain the lethal arrhythmias of ventricular fibrillation (VF) and ventricular insight into abnormal cardiac function, such as arrhythmias. In this paper we discuss the is- sues

  15. The rule of bigeminy revisited: analysis in sudden cardiac death syndrome Claudia Lerma, PhD,a,b

    Biology and Medicine Websites

    Glass, Leon

    afterdepolarizations. We evaluated these ventricular arrhythmias over extended periods in patients with sudden cardiac on the self-perpetuation of the arrhythmias. Results: Eight (53%) patients had classic torsade de pointes (Td bigeminy (N5% of total ventricular arrhythmias), (2) long corrected QT interval (N0.5 second), (3

  16. Non-cell autonomous effects on integrin signalling on neurogenesis in the chick embryonic CNS 

    Edinburgh, University of - Research Archive

    Long, Katherine

    2013-11-28

    . The integrin subunits ?6 and ?1, which heterodimerise into a laminin receptor, are highly expressed within the NSCs of the embryonic ventricular zone and loss of integrin ?1 (itg?1) function within the ventricular zone of the embryonic mouse results in NSC...

  17. INTRODUCTION While the importance of cell migration in cortical development

    Biology and Medicine Websites

    Polleux, Franck

    zone, and can enter the cortical plate from either location. Tangential migration is strongly recently, the dominant view was that most cortical neurons left the ventricular zone after their last knockout mice, two homeobox genes that are expressed in the ventricular and subventricular zones of the GE

  18. Neuron, Vol. 12, 1353-1362, June, 1994, Copyright 0 1994 by Cell Press Embryonic Expression of Myelin Genes: Evidence for

    Biology and Medicine Websites

    Richardson, William D.

    oligodendrocyte progenitor cells. In situ hybridization revealed a thin longitudinal column of CNP-positive cells in the ventral ventricular zone of the embryonic day 14 rat spinal cord, coincident in time and space with cells location in the ventral ventricular zone of the embryonic day 14 rat spinal cord. We further report

  19. EDITORIAL COMMENTARY Precordial thump and commotio cordis: The yin and yang

    Biology and Medicine Websites

    by electric shock proved to be highly successful in terminating ventricular tachycardia (VT) and ventricular arrested hearts.9 Simi- lar to electric shock, precordial thump or any mechanical impact to the chest may(s) with the R wave of the ECG was proposed to increase the success of mechanical cardio- version.15 The efficacy

  20. 1. The T1-weighted MR images of all the subjects were first linearly registered to

    Mathematics Websites

    Wang, Yalin

    a group averaged atlas in which the nonlinear deformation for each CSF mask was estimated. 4. The ALVIN the lateral ventricles. 5. Warping back the group average ventricular atlas by referring the nonlinear of limited use for surface-based ventricular morphometry. In this study, we present a novel automated atlas

  1. doi:10.1152/ajpheart.01300.2005 291:H184-H192, 2006. First published 24 February 2006;Am J Physiol Heart Circ Physiol

    Engineering Websites

    Development of an anatomically detailed MRI-derived rabbit ventricular model and [PDF][Full Text, destabilization, and termination of ventricular tachycardia (VT) by low-energy shocks in isolated rabbit right. Termination by unpinning occurred in all 22 preparations. Rayleigh's test showed a statistically significant

  2. VOLUME 86, NUMBER 16 P H Y S I C A L R E V I E W L E T T E R S 16 APRIL 2001 Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation

    Physics Websites

    Sinha, Sitabhra

    behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular death, is responsible for about one out of every six deaths in the U.S. [1,2]. In the absence of any attempt at defibrillation, VF leads to death in a few minutes. The im- portance of this problem can hardly

  3. Proc. Intl. Soc. Mag. Reson. Med 9 (2001) 1 Automated Segmentation of Cardiac Magnetic Resonance Images

    Mathematics Websites

    2001-01-01

    University of Denmark, Richard Petersens Plads, Building 321, DK-2800 Lyngby, Denmark; 2Danish Research- standard for cardiac imaging [1]. Measurement of ventricular volumes, muscle mass and function is based

  4. Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging

    University of Kansas - KU ScholarWorks

    Loganathan, Rajprasad; Bilgen, Mehmet; Al-Hafez, Baraa; Alenezy, Mohammed D.; Smirnova, Irina V.

    2006-04-04

    . The functional abnormalities of diabetic myocardium have been attributed to the pathological changes of diabetic cardiomyopathy. Methods: In this study, we used high field magnetic resonance imaging (MRI) to evaluate the left ventricular functional...

  5. Present Understanding of Shock Polarity for Internal Defibrillation: The Obvious and Non-Obvious Clinical

    Engineering Websites

    reversal during an implant to deal with a high defibrillation threshold (DFT). We feel that this practice for the prevention of death in patients prone to ventricular tachyarrhythmias. The growing body of clinical research

  6. Bi-temporal 3D Active Appearance Models with Applications to Unsupervised Ejection Fraction Estimation

    Mathematics Websites

    and a realistic economy within the health sector. The recently Nobel Prize awarded magnetic resonance imaging (MRI and the left ventricular blood pool. Solutions will thus be imputed by these models in areas exhibiting weak

  7. Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats

    Biotechnology Websites

    Storey, John D.

    intra-acinar pulmonary arteries, converting it to a neointimal response (28). In this model, rats demonstrate an initial gradual increase in pulmonary arterial and right ventricular systolic pressures (RVSPs

  8. An assay for permeability of the zebrafish embryonic neuroepithelium

    MIT - DSpace

    Chang, Jessica T.

    The brain ventricular system is conserved among vertebrates and is composed of a series of interconnected cavities called brain ventricles, which form during the earliest stages of brain development and are maintained ...

  9. Evidence regarding clinical use of microvolt T-wave alternans

    MIT - DSpace

    Hohnloser, Stefan H.

    Microvolt T-wave alternans (MTWA) testing in many studies has proven to be a highly accurate predictor of ventricular tachyarrhythmic events (VTEs) in patients with risk factors for sudden cardiac death (SCD) ...

  10. An apparatus for high throughput muscle cell experimentation

    MIT - DSpace

    Garcia-Webb, Michael G. (Michael Gregory)

    2006-01-01

    The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

  11. , 20131189, published 12 March 2014112014J. R. Soc. Interface Dimos Poulikakos and Vartan Kurtcuoglu

    Physics Websites

    Daraio, Chiara

    , Institute of Physiology, 5 Neuroscience Center Zurich, and 6 Zurich Center for Integrative Human Physiology are simulated in the ventricular space using subject-specific anatomy, wall motion and choroid plexus pulsations

  12. INTRODUCTION Oligodendrocytes, the myelinating cells of the central nervous

    Biology and Medicine Websites

    Richardson, William D.

    ., 1994). They originate in the ventricular and subventricular zones of the embryo (Pringle and Richardson; Ono et al., 1997; Pringle et al., 1998). In the rodent optic nerve they start to generate myelinating

  13. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    MIT - DSpace

    Wang, Xinchen

    The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate ...

  14. Approximations to Magic: Finding Unusual Medical Time Series Jessica Lin Eamonn Keogh Ada Fu Helga Van Herle

    Computer Technologies and Information Sciences Websites

    Fu, Ada Waichee

    ventricular contraction As we shall show, time series discords are superlative anomaly detectors, able of electrocardiogram qtdb/sel102 (marked in bold line). The location of the discord exactly coincides with a premature

  15. Ascites syndrome mortality and cardiological response of broiler chickens subjected to cold exposure: effects of verapamil and L-carnitine supplementation 

    Texas A&M University - TxSpace

    Stolz, Jennifer Lee

    1993-01-01

    -exposed population. RV/TV, RV/LV ratios were significantly increased by cold exposure in the ascitic population. Verapamil had no apparent effect on these variables. The ECG analysis employed accurately reflected the right ventricular hypertrophy observed...

  16. Cystatin-C and mortality in elderly persons with heart failure

    University of California eScholarship Repository

    2005-01-01

    with heart failure (HF). 279 Cardiovascular Health StudyHeart Failure GFR = Glomerular Filtration Rate CHS = Cardiovascular Healthheart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health

  17. Detection of Cardiac Alternans via Statistical Analysis of Eigenvalues of a Dynamical System

    Engineering Websites

    Zhao, Xiaopeng

    and prevention of ventricular fibrillation, a heart rhythm disorder that kills hundreds of thousands of people kills 350,000 Americans each year [2]. To develop an understanding of cardiac rhythm instability, we

  18. Mapping myocardial structure-function relations with cardiac diffusion and strain MRI

    MIT - DSpace

    Dou, Jiangang, 1972-

    2002-01-01

    The myocardial structure-function relation is the key to understand the functional design of the ventricular myocardium. While the function of myocardial fibers has been extensively studied, the recently observed laminar ...

  19. July 2010 Volume 6, Number 1 www.thejns.org

    Engineering Websites

    ) abnormal brain enlargement was accompanied by increased CSF volume along with parenchymal edema. In this latter pattern, spontaneous ventricular rupture led to normalization of brain volume, implying edema from

  20. Simulation of the Three-Dimensional Hinge Flow Fields of a Bileaflet Mechanical Heart Valve Under Aortic Conditions

    University of California eScholarship Repository

    Simon, Hélène A.; Ge, Liang; Sotiropoulos, Fotis; Yoganathan, Ajit P.

    2010-01-01

    by a rotating ?ow with large out-of-plane vertical velocityleakage jets have large out-of-plane vertical component aslarge-scale simulation and used as boundary ?ow conditions for the ventricular plane

  1. Development/Plasticity/Repair Dorsally and Ventrally Derived Oligodendrocytes Have

    Biology and Medicine Websites

    Richardson, William D.

    from the ventral ventricular zone (VZ) under the influence ofSonicHedgehog,butaminorityaregeneratedfromthedorsalVZinaHedgehog is Sonic Hedgehog (SHH) dependent, but dorsally derived OLPs are SHH independent, possibly relying

  2. Philadelphia University Faculty of Engineering

    Multidisciplinary Databases and Resources Websites

    , Visualisation of drug delivery to the human brain, The 7th international symposium on fluid control, Hydrodynamics of Cerebrospinal Fluid and Drug delivery in a model of the Human Ventricular system. ODE Journal

  3. Cardiovascular effects of apelin in vivo in man 

    Edinburgh, University of - Research Archive

    Japp, Alan Gordon

    2013-07-06

    Background The apelin system is a novel peptidic pathway widely expressed in the heart and vasculature. In preclinical studies, apelin receptor agonism mediates nitric oxide-dependent vasodilatation, reduces ventricular ...

  4. CONTROL OF CARDIAC ALTERNANS IN A MAPPING MODEL WITH MEMORY ELENA G. TOLKACHEVA

    Physics Websites

    Gauthier, Daniel

    caused by ventricular arrhythmias, is a major public health problem: it is one of the leading causes of mortality in the western world. A possible precursor of some arrhythmias is the beat-to-beat variation

  5. Identification of intracellular calcium dynamics in stimulated cardiomyocytes

    Computer Technologies and Information Sciences Websites

    Politècnica de Catalunya, Universitat

    related to anomalies at the cellular level such as ventricular reentrant arrhythmias. I. INTRODUCTION of the cell, is known to be related to the apparition of lethal arrhythmias [8]­[10]. The purpose of this work

  6. A rt i c l e s 624 VOLUME 20 | NUMBER 6 | JUNE 2014 nAture medicine

    Biology and Medicine Websites

    Grabe, Michael

    potentials are prolonged15 and intracellular calcium overload occurs16, which results in arrhythmias16 and abnormal T-tubule morphology12,13,19,20. A case of ventricular arrhythmia associated with BIN1 mutation has

  7. CLASSIFICATION OF ATRIAL FIBRILLATION PRONE PATIENTS USING ELECTROCARDIOGRAPHIC PARAMETERS IN NEURO-FUZZY MODELING

    Computer Technologies and Information Sciences Websites

    Simon, Dan

    cardiac arrhythmia 2.5 million people/year (US only). ·During AF, electrical impulses originate from many has been associated with stroke, ventricular arrhythmias and the need for permanent pacemakers. ·A

  8. A method for guiding ablation catheters to arrhythmogenic sites using body surface electrocardiographic signals

    MIT - DSpace

    Barley, Maya E.

    Treatment of hemodynamically unstable ventricular arrhythmias requires rapid and accurate localization of the reentrant circuit. We have previously described an algorithm that uses the single-equivalent moving dipole model ...

  9. Cleveland Clinic, Anesthesiology Institute, 2 Cleveland State University, Electrical and Computer Engineering Department,

    Computer Technologies and Information Sciences Websites

    Simon, Dan

    : stroke, ventricular arrhythmias, and permanent pacemakers · Method to identify patients with highest AF common cardiac arrhythmia: 2.5 million people/year/US; > 350/min electrical impulses from ectopic sources

  10. Final report on EPSRC project EP/D074789/1 + EP/D074746/1 I.V. Biktasheva, D. Barkley, V.N. Biktashev

    Mathematics Websites

    Biktashev, Vadim N.

    -entrant arrhythmias, including the most lethal one, the ventricular fib- rillation. Under ideal conditions, a spiral electrophysiology: researchers working in experimental studies of re-entrant arrhythmia and their mathematical

  11. Z .European Journal of Pharmacology 342 1998 93104 Effects of bisaramil, a novel class I antiarrhythmic agent, on heart,

    Biology and Medicine Websites

    Goldin, Alan L.

    for the drug treatment of cardiac arrhythmias. Lidocaine is a local anesthetic that is used in the clinical setting to suppress ventricular arrhythmias. It is both a tonic and use-dependent blocker of cardiac Naq

  12. Prediction of Paroxysmal Atrial Fibrillation (PAF) Onset through

    Computer Technologies and Information Sciences Websites

    in Electrical Engineering and Computer Science Abstract PAF is a type of progressive cardiac arrhythmia that poses severe health risks, sometimes leading to ventricular arrhythmia and post-operative mortality

  13. Appl. Phys. B 72, 859863 (2001) / Digital Object Identifier (DOI) 10.1007/s003400100562 Applied Physics B

    Engineering Websites

    2001-01-01

    of helicobacter pylori, which causes ventricular ulcers [5]). De- tection of biomedically-produced NO and its absorption lines can be selected to avoid interference from other species such as CO2 and H2O absorbing

  14. Spectral analyses of avian heart value sounds 

    Texas A&M University - TxSpace

    Jeyaseelan, Prithika

    1993-01-01

    Cardiovascular changes which occur in response to cardiac stress affect the heart valve sounds (HVS). We attempted to quantify the effect of pulmonary hypertension and right ventricular (RV) hypertrophy on the frequency spectrum of HVS. A test...

  15. Integrin alpha 5 beta 1 is necessary for regulation of radial migration of cortical neurons during mouse brain development

    MIT - DSpace

    Marchetti, Giovanni

    During cerebral cortex development, post-mitotic neurons interact with radial glial fibers and the extracellular environment to migrate away from the ventricular region and form a correct laminar structure. Integrin receptors ...

  16. Three-Dimensional Stress and Strain in Passive Rabbit Left Ventricle: A Model Study

    Biology and Medicine Websites

    Vetter, Frederick J.

    measured in rat, canine, and porcine hearts.15,27,26 Despite experimental evidence that left ventricular the left and right ventricles RV , the pericardium, or coronary blood flow. Hence more sophisticated models

  17. Int. J. Comput. Intelligence in Bioinformatics and Systems Biology, Vol. X, No. Y, xxxx 1 Copyright 200x Inderscience Enterprises Ltd.

    Computer Technologies and Information Sciences Websites

    Bargiela, Andrzej

    modelling, information abstraction, parallel computing, artificial intelligence, fuzzy sets clustering method and apply it to brain magnetic resonance imaging (MRI) lateral ventricular compartments of uncertainty in the context of modelling and simulation of various physical and engineering systems. His

  18. Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model

    University of Kansas - KU ScholarWorks

    ZM, Binsalamah; Paul, Arghya; Khan, Afshan Afsar; Prakash, Satya; Shum-Tim, Dominique

    2011-10-31

    Acute myocardial ischemia results in scar formation with ventricular dilatation and eventually heart failure. Placental growth factor (PlGF) is reported to stimulate angiogenesis and improve cardiac function. In this study, ...

  19. New Approaches to the Surgical Management of

    Biology and Medicine Websites

    Kornfeld, S. Kerry

    New Approaches to the Surgical Management of Hypertrophic Obstructive Cardiomyopathy Ralph J University and Barnes-Jewish Heart & Vascular Center #12;New Approaches to the Surgical Management B HCM = hypertrophic cardiomyopathy; LVOTO = left ventricular outflow tract obstruction; NYHA = New

  20. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons

    MIT - DSpace

    Pinheiro, Elaine M.

    During corticogenesis, pyramidal neurons (~80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia[superscript 1], [superscript 2], and then ...

  1. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons

    MIT - DSpace

    Pinheiro, Elaine M.

    During corticogenesis, pyramidal neurons (~80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia[superscript 1, 2], and then migrate to their ...

  2. Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

    MIT - DSpace

    Majmudar, Maulik D.

    Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, ...

  3. Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model

    University of Kansas - KU ScholarWorks

    Binsalamah, Ziyad Mohammed; Paul, Arghya; Khan, Afshan Afsar; Prakash, Satya; Shum-Tim, Dominique

    2011-10-31

    Acute myocardial ischemia results in scar formation with ventricular dilatation and eventually heart failure. Placental growth factor (PlGF) is reported to stimulate angiogenesis and improve cardiac function. In this study, it was hypothesized...

  4. Essentials of Low-Power Electrocution: Established and Speculated Mechanisms

    Biology and Medicine Websites

    Illinois at Urbana-Champaign, University of

    lightning and power lines. Low-power electrocution induces ventricular fibrillation (VF). We review the 3-voltage" electrocutions in- clude lightning and power line sources. A 7600 V power line can easily deliver about 60 k

  5. Peripartum Cardiomyopathy: Predictors of Recovery

    University of Kansas - KU ScholarWorks

    Pillarisetti, Jayasree

    2013-08-31

    ventricular arrhythmias and underwent ICD implantation in a tertiary hospital in California, 3 of the ICDs were CRTDs (39). Similarly 3 of 14 patients without improvement underwent ICD implantation in a recent prospective study in Europe (36). Reasons... of 680 PPCM patients in North Carolina reported a high mortality rate of 16% (40) in these young women. Sudden death due to ventricular 14 arrhythmias occurred in 38% of women while 46% died of progressive heart failure and 15% from unknown causes...

  6. Concept Visualization Descriptor Details

    Computer Technologies and Information Sciences Websites

    Bhandarkar, Suchendra "Suchi" M.

    . The association between the incidence and extent of coronary artery disease and the alterations in the endocardial, Shape analysis of left ventricular endocardial surface and its application in detecting coronary artery endocardial surface morphology and the incidence and extent of stenosis in a specific coronary artery

  7. Mapping CSF Changes in First Episode Schizophrenia Katherine L. Narr; 2,3

    Biology and Medicine Websites

    Thompson, Paul

    space were then measured within a sphere of fixed radius at thousands of homologous surface locations of CSF enlargements near the time of disease onset, however, is less well characterized. In this study, we used computational image analysis methods to map regional changes in lateral ventricular volume

  8. (Created 8/03; Revised 5/04, 7/06, 5/08, 1/12) UNL Environmental Health and Safety (402) 472-4925 http://ehs.unl.edu

    Physics Websites

    Tsymbal, Evgeny Y.

    muscle due to sudden loss of blood supply. Death of the heart muscle often causes chest pain and electrical instability of the heart muscle tissue. Electrical instability of the heart causes ventricular buildings. In addition, portable AEDs are brought on-site during large events, such as graduation, athletic

  9. Evidence for the Presence of Calsequestrin in Two Structurally Different Regions of

    Biology and Medicine Websites

    Campbell, Kevin P.

    Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S IA8; and * Department of Physiology and Biophysics, Bowen Science Building, University of Iowa, Iowa City, Iowa 52242 ABSTRACT Localization of calsequestrin in chicken ventricular muscle cells was determined by indirect immunofluorescence and immuno

  10. IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 9, NO. 4, APRIL 2000 651 Multiframe Temporal Estimation of Cardiac Nonrigid

    Engineering Websites

    Nehorai, Arye

    of Cardiac Nonrigid Motion John C. McEachen, II, Member, IEEE, Arye Nehorai, Fellow, IEEE, and James S motion of the left ventricular (LV) endocardial wall in image sequences has been developed. This system is unique in its ability to model motion trajectories across multiple frames. The foundation of this system

  11. P1: NBL/mbg/spd P2: NBL/ary QC: NBL/anil T1: NBL December 30, 1998 9:51 Annual Reviews AR076-19

    Biology and Medicine Websites

    Sereno, Martin

    NERVOUS SYSTEM NEURONAL MIGRATION Mary E. Hatten The Rockefeller University, 1230 York Avenue, New York, cortex, cerebellum ABSTRACT Widespread cell migrations are the hallmark of vertebrate brain development, after primary neu- rogenesis in compact ventricular zones has commenced, individual postmitotic cells

  12. Neuron, Vol. 17, 5561, July, 1996, Copyright 1996 by Cell Press Restriction of Late Cerebral Cortical Progenitors

    Biology and Medicine Websites

    McConnell, Susan

    cell types in thevertebrate nervous system (e.g., however, cortical progenitors normally produce neu-the developmental potential of early cortical progenitor planted into ferret host brains on E32, when the deep to heterochronic trans-brains at the time of upper-layer neurogenesis (McCon- plants, control ventricular cells

  13. DOI 10.1007/s10665-014-9740-3 Parameter estimation in a HolzapfelOgden law for healthy

    Mathematics Websites

    Luo, Xiaoyu

    J Eng Math DOI 10.1007/s10665-014-9740-3 Parameter estimation in a Holzapfel­Ogden law for healthy procedure. Our study, based on three different healthy volunteers, demonstrates that the parameters of left ventricular (LV) mechanics provides unique insights into LV functions in both diseased and healthy

  14. TMEM43 Mutation p.S358L Alters Intercalated Disc Protein Expression and Reduces Conduction Velocity in

    Materials Science Websites

    Sun, Yu

    in Arrhythmogenic Right Ventricular Cardiomyopathy Vinayakumar Siragam1 , Xuezhi Cui1 , Stephane Masse2 , Cameron , Robert M. Hamilton1 * 1 Physiology and Experimental Medicine, The Hospital for Sick Children and Research exist. * Email: robert.hamilton@sickkids.ca Introduction TMEM43 (also called LUMA) [1] is a 43 kDa

  15. PreparticipationPhysicalEvaluation HISTORYFORM

    Computer Technologies and Information Sciences Websites

    Missouri-Rolla, University of

    or atlantoaxial instability? (Down syndrome or dwarfism) 22. Do you regularly use a brace, orthotics, or other infant death syndrome)? 14. Does anyone in your family have hypertrophic cardiomyopathy, Marfan syndrome, arrhythmogenic right ventricular cardiomyopathy, long QT syndrome, short QT syndrome, Brugada syndrome

  16. Remote Visualization and Computational Steering of Cardiac Virtual Tissues using gViz

    Computer Technologies and Information Sciences Websites

    Brodlie, Ken

    Abstract Cardiac tissue engineering - detailed biophysical, histological and anatomical models of the heartRemote Visualization and Computational Steering of Cardiac Virtual Tissues using gViz OV Aslanidi1 of interacting re-entrant waves. Fig. 1 shows some examples of these behaviours. Virtual ventricular tissues

  17. LETTER doi:10.1038/nature10852 Circadian rhythms govern cardiac repolarization

    Biotechnology Websites

    hereditary disorders, for example, Brugada's syndrome, fatal ventricular arrhythmias often occur during sleep). First, prolongation of repolarization is seen in acquired disorders (for example, heart failure)5 and congenital disorders (for example, long QT syndrome)3 . Second, shortening of repolarization is found

  18. Classification of Rhythmic Patterns Stomatogastric Ganglion

    Physics Websites

    Roberts, Patrick D.

    ganglion; STNS, stomatogastric nervous system; VD, ventricular dilator. Running title: Stomatogastric Rhythms 1 #12;Abstract--There is a large class of central pattern generators that may change of theoretical tools is essential for a thorough understanding of complex biological systems. At the present time

  19. The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a

    Physics Websites

    Henry, Hervé

    heterogeneities of cardiac tissue due to M cells in the generation and maintenance of reentrant excitations using to ventricular #12;brillation, the leading cause of sudden death in the industrialized world. In this numerical and maintenance of reentrant excitations. These cells, located in the midmyocardium, exhibit a prolonged action

  20. *Author to whom correspondence should be addressed. E-mail: keener@math.utah.edu.

    Biology and Medicine Websites

    Keener, James P.

    . KEENER* AND T. J. LEWIS Department of Mathematics, ;niversity of ;tah, Salt ¸ake City, ;¹ 84112, ;.S is more e!ective than a monophasic shock at eliminat- ing reentrant electrical activity in an ionic model of cardiac ventricular electrical activity. This e!ectiveness results from early hyperpolarization

  1. 417ISSN 1755-530210.2217/ICA.11.50 2011 Future Medicine Ltd Interv. Cardiol. (2011) 3(4), 417419 Cardiovascular medicine has benefited, both

    Materials Science Websites

    Rogers, John A.

    2011-01-01

    and treat anato-pathologic conditions and diseases previously treated medically, often with limited efficacy, or surgically via open invasive procedures. The dramatic shift in the treatment of coronary artery disease (CAD of the future increasingly incapacitated by angina or ischemia- mediated ventricular dysfunction as disease

  2. NFIX Regulates Neural Progenitor Cell Differentiation During Hippocampal Morphogenesis Yee Hsieh Evelyn Heng1, Robert C. McLeay3, Tracey J. Harvey1, Aaron G. Smith1, Guy Barry2, Kathleen Cato1, Cline Plachez4,

    Biology and Medicine Websites

    Gronostajski, Richard M.

    the cortex remain poorly defined. Here, we demonstrate that Nuclear factor one X (NFIX) is expressed, nuclear factor one X, SOX9 Introduction During nervous system formation, one of the most important the proliferative ventricular zone, region executing a program of proliferation, then differentiation, to generate

  3. Introduction The epsilon 4 allele of the apolipoprotein E gene (APOE4) is a well-established risk factor for

    Biology and Medicine Websites

    Thompson, Paul

    expansion. However, so far, it is unknown how APOE4 and TOMM40 SNPs influence rates of ventricular expansion of neurodegeneration (expansion) associated with the genotypes. Permutations tests were used to correct for multiple expansion. 3D statistical maps show the associations predominantly in the body and occipital horn, stronger

  4. European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2012)

    Engineering Websites

    Mittal, Rajat

    , systolic murmur Abstract. We propose a multiphysics simulation approach for predicting cardiac flows and the virtual PC is used to model systolic murmurs caused by hypertrophic cardiomyopathy(HCM). This "virtual as well as diseased hearts, and in doing so, may reveal the significance of flow structures on ventricular

  5. Original Research Single-Breathhold, Four-Dimensional, Quantitative

    Engineering Websites

    Southern California, University of

    (LV) and right ventricular (RV) function in heart failure patients. Materials and Methods: A total and accurate assessment of RV and LV function in a single-breath hold. Using the same strategy, increased-Liss, Inc. ACCURATE AND REPRODUCIBLE assessment of car- diac function and chamber volume is vital

  6. RESEARCH Open Access Semi-automatic algorithm for construction of the

    Engineering Websites

    Carvalho, João Luiz

    -axis images during diastole is troublesome, because of the opening of the mitral valve. Methods: This work potentially be used for evaluating the global systolic function of the left ventricle. Background Two and functional characteristics may be assessed. The analysis of left ventricular function is extre- mely

  7. Surface Multivariate Tensor-based Morphometry on Premature Neonates: A Pilot Study

    Mathematics Websites

    Wang, Yalin

    anatomy of subcortical structures between healthy preterm and term-born neonates. We first reconstruct become possible to detect and track how neurological disorders affects brain anatomy, and in particular the anatomy of subcortical structures. For example, hippocampal and #12;ventricular surface morphology have

  8. Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior

    Materials Science Websites

    Stanley, H. Eugene

    correlations scaling Adverse cardiac events are the leading cause of mortality in the United States (1 from scheduled behav- iors and mean heart rate. Cardiac dynamics under pathologic condi- tions infarction (2­6), stroke (7, 8), angina (9), ventricular arrhythmias (10), and sudden cardiac death (11, 12

  9. Supported by NIH NINDS NS 35115 (AVA) and NIA AG00940 (DRG)

    Biology and Medicine Websites

    Apkarian, A. Vania

    artifacts in the temporal lobes, it has a TR = 22 ms. · Total neocortical gray matter volumes were calculated after excluding the cerebellum, deep gray matter and brainstem. Normalized lateral ventricular gray matter volume was compared using a skull-based normalization (Sienax, FMRIB, Oxford, UK; Smith S

  10. Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

    Condensed Matter (arXiv)

    A. S. Moskvin; A. M. Ryvkin; O. E. Solovyova; V. S. Markhasin

    2011-03-31

    We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

  11. ISSN: 1524-4571 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online

    Biology and Medicine Websites

    was to construct a detailed anatomic model of the AVN and relate it to AVN function. The electric activity, His bundle, atrial and ventricular muscle, central fibrous body, tendon of Todaro, and valves. A 3D and ventricle, incorporating all cell types, was constructed. Comparison of the model with electric activity

  12. This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research

    Biology and Medicine Websites

    Thompson, Paul

    (MRI) data. With tensor-based morphometry (TBM), we mapped the 3-dimensional profile of progressive% in ventricular expansion, for every 10-year decrease in age. TBM-derived atrophic rates correlated with reduced in clinical measures, and increasing numbers of risk alleles for the ApoE4 gene. TBM is a sensitive, high

  13. Hyperbolic Ricci Flow and Its Application in Studying Lateral Ventricle Morphometry

    Mathematics Websites

    Wang, Yalin

    Hyperbolic Ricci Flow and Its Application in Studying Lateral Ventricle Morphometry Jie Shi1 , Paul brain morphology with the Ricci flow method. Two surfaces are conformally equivalent if there exists be computed by geodesic lengths under hyperbolic metric. For lateral ventricular sur- face registration, we

  14. Regulated Nuclear Trafficking of the Homeodomain Protein Otx1 in Cortical Neurons

    Biology and Medicine Websites

    McConnell, Susan

    Regulated Nuclear Trafficking of the Homeodomain Protein Otx1 in Cortical Neurons Y. Alex Zhang,1 in the rat ventricular zone, and remains cytoplasmic as neurons migrate and begin to differentiate. Nuclear, that the N-terminus of Otx1 is nec- essary for nuclear import, and that a putative nuclear localization

  15. Biomedical Engineering Correlation Between Vortex Ring Formation and Mitral

    Biology and Medicine Websites

    Kheradvar, Arash

    of mitral annulus approximate the physiologic and pathologic values. Digital particle image velocimetry value in a healthy left ventricle. We also tested annulus diameters smaller and larger than the normal of the ventricular flow5,6 and subsequently confirmed by analyses based on color Doppler mapping7,8 and magnetic

  16. Journal of Fish Biology (1998) 52, 11541164 Cardiac conduction times in Sparus auratus at different

    Environmental Sciences and Ecology Websites

    Altimiras, Jordi

    1998-01-01

    and fish weight was observed, suggesting a similar conduction speed of the excitatory wave and the presence not involve surgery (Miller et al., 1980; Laitinen & Valtonen, 1995). The use of radio or acoustic telemetry of the characteristic P, R and T waves, corresponding to atrium depolarization and ventricular de- and repolarization

  17. Using High Resolution Cardiac CT Data to Model and Visualize Patient-Specific

    Chemistry Websites

    Chen, Kuang-Yu

    , such as the papillary muscles and the ventricular tra- beculae. We use visualizations of the flow field to view change. This affects the motion of blood through the heart, potentially leading to an increased risk). (a) Healthy heart (b) Diseased heart. heart walls in the simulation, including the papillary muscles

  18. LETTER doi:10.1038/nature10405 Genetic variants in novel pathways influence blood

    Mathematics Websites

    Abecasis, Goncalo

    stimuli. Over one billion people worldwide have hypertension ($140 mm Hg systolic blood pressure or $90 mm was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease blood pressure (SBP), diastolic blood pressure (DBP) and hypertension5,6 . We now report results

  19. PERIOPERATIVE MEDICINE Anesthesiology 2010; 113:78293 Copyright 2010, the American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins

    Environmental Sciences and Ecology Websites

    Peak, Derek

    fibrillation or pulseless ventricular tachycardia in 259 hospitals participating in the National Registry diagnosis. The association between delayed defibrillation and survival to hospital discharge differed the operat- ing room, delayed defibrillation was associated with a lower probability of surviving to hospital

  20. A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis

    Materials Science Websites

    Parker, Kevin Kit

    of finite volume growth characterized through the multiplicative decomposition of the deformation gradient backward scheme. We explore a generic bi-ventricular heart model in response to volume- and pressure Finite element method Hypertrophic cardiomyopathy Sarcomerogenesis a b s t r a c t We present a novel

  1. J. theor. Biol. (1990) 146, 407-432 Chaotic Dynamics in an Ionic Model of the Propagated Cardiac

    Biology and Medicine Websites

    Guevara, Michael R.

    1990-01-01

    of iteration of the map and the results of the numerical integration of the cable equation. Calculation of ventricular muscle by numerically integrating the one-dimensionalcable equation using the Beeler-Reuter model consideration of the dynamics of a partial differential equation (which is of infinite dimension

  2. Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

    CERN Preprints

    Moskvin, A S; Solovyova, O E; Markhasin, V S

    2011-01-01

    We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

  3. Application of blebbistatin as an excitationcontraction uncoupler for electrophysiologic study of rat and rabbit hearts

    Engineering Websites

    of rat and rabbit hearts Vadim V. Fedorov, PhD,* Ilya T. Lozinsky, PhD Eugene A. Sosunov, PhD , Evgeniy P rabbit hearts, isolated rabbit right ventricle and right atrium, and single rat ventricular myocytes for optical imaging of cardiac tissues. KEYWORDS Blebbistatin; Heart; Contraction; Myosin II; Action potential

  4. Enro.sagepub.com ISSN: 1073-8584

    Biology and Medicine Websites

    Ruthazer, Edward

    came further support for the idea of RG as a scaffold for neuronal migration from the ventricular zone to cortical layers in midgestational human and monkey. The majority of young neurons were observed zone to the upper cortical layers (Rakic 1972; Sidman and Rakic 1973). The apparent postnatal

  5. EphB2 regulates axonal growth at the midline in the developing auditory brainstem

    Biology and Medicine Websites

    Cramer, Karina

    at the ventral floor plate. Expression extends dorsally to the ventricular zone beginning at E5. NM axons thus (Jhaveri and Morest, 1982a; Smith and Rubel, 1979; Young and Rubel, 1983). Contralateral axons have orderly-Snir et al., 1998; Carr and Konishi, 1990; Overholt et al., 1992; Young and Rubel, 1983). The length

  6. V. Cortical Development and Neural Disorder Fates and functions of NG2 cells in the postnatal CNS

    Biology and Medicine Websites

    Fukai, Tomoki

    : Oligodendrocyte precursors (OLPs, also known as NG2 cells) are generated in the ventricular zones (VZ: Richardson, W.D., Young, K.M., Tripathi, R.B., and McKenzie, I. (2011). NG2-glia as multipotent neural stem cells: fact or fantasy? Neuron 70, 661-673. Tripathi, R.B., Rivers, L.E., Jamen, F. Young, K

  7. INTRODUCTION During development, many young neurons migrate from their

    Biology and Medicine Websites

    McConnell, Susan

    INTRODUCTION During development, many young neurons migrate from their site of origin to the final position in which they differentiate. In the cerebral cortex, neurons are generated in the ventricular zone and migrate out through the intermediate zone and into the cortical plate, where they differentiate and form

  8. Development/Plasticity/Repair The CoxsackievirusAdenovirus Receptor Reveals Complex

    Biology and Medicine Websites

    ¨nchen, Germany, and 5Freie Universita¨t Berlin, 14195 Berlin, Germany The coxsackievirus­adenovirus receptor (CAR investigations during development reveal an initial uniform distribution of CAR on all neural cells and the ventricular side). At more advanced stages, CAR becomes downregulated and restricted to specific regions

  9. THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 269, No. 45, Issue of November 11, pp. 28359-28365, 1994 1994 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A.

    Biology and Medicine Websites

    Campbell, Kevin P.

    to the 90 kDa protein was not detected in ventricular myocytes or vascular smooth muscle cells-C coupling) is the signal transduction process by which depolarization of the muscle cell membrane triggers contraction. In skeletal muscle, E-C coupling is medi- ated by morphologically specialized structures known

  10. Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1472614729, December 1996

    Biology and Medicine Websites

    Springer, Timothy A.

    identified as a bone marrow stromal cell-derived factor and as a pre-B-cell stimulatory factor. Although most viability, B lymphopoiesis, bone marrow myelopoiesis, and cardiac ventricular septal formation, and it has) is a member of the CXC group of chemokines that is initially identified as a bone marrow stromal cell

  11. Figure 1: Left ventricle endo-surface segmentation meshes were dissected into two halves, the septum

    Computer Technologies and Information Sciences Websites

    Bhandarkar, Suchendra "Suchi" M.

    , the septum (on the left) and the free wall (on the right). (a) is from a normal heart, and (b) is from a diseased heart. SHAPE ANALYSIS OF THE LEFT VENTRICULAR ENDOCARDIAL SURFACE AND ITS APPLICATION IN DETECTING *Piedmont Heart Institute, Atlanta, Georgia 30309, USA Introduction The complex 3D geometrical structure

  12. ESTIMATING MECHANICAL PROPERTIES OF THE HEART USING DYNAMIC MODELING AND MAGNETIC RESONANCE IMAGING

    Engineering Websites

    Nehorai, Arye

    ESTIMATING MECHANICAL PROPERTIES OF THE HEART USING DYNAMIC MODELING AND MAGNETIC RESONANCE IMAGING mechanical properties of the heart using magnetic resonance imaging (MRI) tissue-tagging and blood pres- sure, in vivo heart. Clinically, they may be useful for developing ventricular function measures with sufficient

  13. Physica A 306 (2002) 211219 www.elsevier.com/locate/physa

    Physics Websites

    Sinha, Sitabhra

    2002-01-01

    monoxide on Pt(1 1 0); and (b) ventricular ÿbrillation in mammalian hearts. Our characterization of spiral concentration and may lead to traveling waves and rotating spirals of adsorbed O. The mammalian heart is an electromechanical organ which pumps blood via rhyth- mic contractions of the atria and ventricles. The heart wall

  14. Multifunctional Interventional Devices for MRI: A Combined Electrophysiology/MRI Catheter

    Biology and Medicine Websites

    Atalar, Ergin

    tachycardias, AV-nodal reentrant tachycardias, ac- cessory pathways, atrial flutter, and idiopathic ventricular (kHz) energy for ablation of arrhythmogenic cardiac tissue. By monitoring the IEGM, arrhythmogenic cardiac tissue can be located and then ablated with RF (kHz) energy. Currently, EP procedures

  15. Oligodendrocyte Specification W D Richardson, University College London,

    Biology and Medicine Websites

    Richardson, William D.

    (ventricular zone (VZ)) of the spinal cord and brain stem can be subdividedalongthedorsal­ventralaxisinto11 precursors (OPCs) but few astrocytes. Overall, appro- ximately 80% of spinal cord oligodendrocytes of the ventral spinal cord at 12.5 days postfertilization (E12.5) in mice, E14 in rats, and E6 or E7 in chick

  16. Receptor tyrosine phosphatase zeta/beta in astrocyte progenitors in the developing chick spinal cord

    Biology and Medicine Websites

    Richardson, William D.

    chick spinal cord. RPTPZ/b was expressed throughout the ventricular zone (VZ) of the developing spinal a single ,9 kbp RPTPZ/b transcript expressed in the embryonic chick spinal cord, indicating that the shorter alternative-splice products of RPTPZ/b found in rodent spinal cord and brain

  17. LKB1 and SAD Kinases Define a Pathway Required for the Polarization

    Biology and Medicine Websites

    Polleux, Franck

    . Barnes,1,2 Brendan N. Lilley,3 Y. Albert Pan,3 Lisa J. Plummer,1 Ashton W. Powell,1 Alexander N. Raines,1. As the brain forms, cortical neurons born at the apical ventricular zone undergo a vectorial migration toward the basal pia, where they form and populate specific layers. Then, as neurons extend neurites, one

  18. Journal of Biomechanics 37 (2004) 12631269 Reassessment of brain elasticity for analysis of

    Mathematics Websites

    Frey, Pascal

    2004-01-01

    Journal of Biomechanics 37 (2004) 1263­1269 Reassessment of brain elasticity for analysis-dimensional finite element model of the human brain/ventricular system is developed and analysed under hydrocephalic loading conditions. It is shown that the Young's modulus of the brain parenchyma used in previous studies

  19. Finite-element simulation of firearm injury to the human cranium A. Mota, W. S. Klug, M. Ortiz, A. Pandolfi

    Engineering Websites

    Ortiz, Michael

    of what is known about how penetrating injuries damage the brain and how this damage is best treated through the brain has major significance. Bullets that traverse the brain stem, multiple lobes of the brain, or the ventricular system (chambers where cerebrospinal fluid is located) are particularly lethal

  20. PULMONARY CIRCULATION AT EXERCISE R NAEIJE, MD, PhD and

    Engineering Websites

    Chesler, Naomi C.

    capillary pressures, up to a 20­25 mmHg threshold associated with interstitial lung edema and altered ventricular function limitation and altered gas exchange by interstitial lung edema. Pharmacological the limits of compensation, resulting in lung edema or right heart failure, or both. Since the essential

  1. Plasma cortisol is associated with accelerated brain atrophy: An Alzheimer's Disease Neuroimaging Initiative (ADNI) study

    Biology and Medicine Websites

    Thompson, Paul

    Plasma cortisol is associated with accelerated brain atrophy: An Alzheimer's Disease Neuroimaging expansion locally at baseline 2) 6% accelerated rate of brain atrophy in the temporo-occipital fusiform gyrus, and 14% accelerated rate of lateral ventricular enlargement at 1-year in the trigone

  2. 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSSIMIC) M07-4 Myocardial Blood Flow from Dynamic PET

    Biology and Medicine Websites

    Duncan, James S.

    ) from dynamic PET requires a reproducible and reliable method to obtain left and right ventricular time of signals from statistically independent sources. The mixing process is due to cardiac motion and partial map of the mixing coefficients that allows the segmentation of structures. Dynamic cardiac PET data

  3. Predicting Postoperative Atrial Fibrillation from Independent ECG Components Chih-Chun Chia, James Blum, Zahi Karam, Satinder Singh, Zeeshan Syed

    Computer Technologies and Information Sciences Websites

    Baveja, Satinder Singh

    rapidly and irregularly, preventing successful emptying of blood into the lower (ventricular) chambers. This causes blood to pool in the heart and clot, producing strokes and other morbidities that increase risk, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved. 1999). However

  4. Luca Gentili e-mail: l.gentili@unibo.it

    Engineering Websites

    Paden, Brad

    of a Maglev Artificial Heart This paper is devoted to the development of an advanced controller for a maglev artificial heart: in particular, a magnetically levitated left ventricular assist device is studied and control engineering and continue to pose intriguing challenges. The term "artificial heart" refers

  5. Testing of Safety-Critical Software Embedded in an Artificial Heart

    Computer Technologies and Information Sciences Websites

    Testing of Safety-Critical Software Embedded in an Artificial Heart Sungdeok Cha1 , Sehun Jeong1 frequently to control medical devices such as artificial heart or robotic surgery system. While much on software controlling a Hybrid Ventricular Assist Device (H-VAD) developed by Korea Artificial Organ Centre

  6. 1068 VOLUME 42 | NUMBER 12 | DECEMBER 2010 Nature GeNetics A rt i c l e s

    Biology and Medicine Websites

    de Bakker, Paul

    with QRS duration and cardiac ventricular conduction Nona Sotoodehnia1,2,78*, Aaron Isaacs3,4,78, Paul I W de Bakker5­8,78, Marcus Dörr9,78, Christopher Newton-Cheh10­12,78, Ilja M Nolte13,78, Pim van der

  7. Sotoodehnia, et al.: QRS GWAS SUPPLEMENTARY MATERIAL: Common variants in 22 loci are associated with QRS

    Biology and Medicine Websites

    de Bakker, Paul

    are associated with QRS duration and cardiac ventricular conduction Nona Sotoodehnia1,2* , Aaron Isaacs3,4* , Paul I.W. de Bakker5,6,7,8* , Marcus Dörr9* , Christopher Newton-Cheh10,11,12* , Ilja M. Nolte13* , Pim

  8. Cardiac MyocyteSpecific Excision of the 1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure

    Biology and Medicine Websites

    Smith, Desmond J.

    versus 88% in controls (n 15 each). By 6 months of age, mice with depressed ventricular expression of 1 murine tissues resulted in gastrulation defects and death by E5.5 of the 21-day gestation period.8 lost from the myocardium of the chimeric mouse heart by 6 months of age. To more specifically evaluate

  9. Hindawi Publishing Corporation International Journal of Biomedical Imaging

    Engineering Websites

    Wang, Ge

    motion and intramural strain/stress in response to ventricular blood pressure and bioelectric stimulus viscoelastic passive properties and active contractility of myocardial tissues, based on the chamber pressure ischemia, hypertrophic my- ocardiopathy, and myocardial dilatation are growingly per- vasive with high

  10. Fax +41 61 306 12 34 E-Mail karger@karger.ch

    Biology and Medicine Websites

    Hooper, Scott

    ;73:26­42 DOI: 10.1159/000202988 Pyloric Neuron Morphology in the Stomatogastric Ganglion of the Lobster microscopy Crustacea Alexa dyes Stomatogastric Panulirus Morphology Lobster Abstract The pyloric network stomatogastric ganglion stn stomatogastric nerve VD ventricular dilator (neuron) #12;Lobster (Panulirus) Pyloric

  11. Structural correlates of psychopathological symptom dimensions in schizophrenia: A voxel-based morphometric study

    Biology and Medicine Websites

    Gaser, Christian

    , temporal and limbic regions as well as the ventricular system. Despite this sub- stantial progress compared to controls were identified within the prefrontal, limbic, paralimbic, temporal and thalamic as limbic and subcortical structures. Thus, structural heterogeneity in schizophrenia may relate to specific

  12. Detection, Properties, and Frequency of Local Calcium Release from the Sarcoplasmic Reticulum in Teleost

    Computer Technologies and Information Sciences Websites

    Politècnica de Catalunya, Universitat

    and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish the baseline fluorescence and the time to half maximal decay of sparks was 2763 ms. Spark frequency was 0 observed in zebrafish ventricular myocytes. In conclusion, this is the first study to consistently report

  13. Lecture notes in Computer Science, vol. 1935, pp. 226-235, Medical Image Computing and Coputer Assisted Intervention MICCAI 2000.

    Biology and Medicine Websites

    Stetten, George

    array [1]. Unlike 3D ultrasound techniques that rely on physically moving a linear array, the scan rate surfaces have been applied to mechanically scanned 3D echocardiographic data [7]. Attempts at applying based on medial features in Real Time 3D echocardiography to locate the left ventricular axis, even

  14. Changes in Large Pulmonary Arterial Viscoelasticity in Chronic Pulmonary Hypertension

    Engineering Websites

    Chesler, Naomi C.

    Changes in Large Pulmonary Arterial Viscoelasticity in Chronic Pulmonary Hypertension Zhijie Wang1 of pulmonary arterial hypertension (PAH) and is an excellent predictor of mortality due to right ventricular at a physiologically relevant frequency (10 Hz) in hypertensive PAs. The dynamic elastic modulus (E), a material

  15. ORIGINAL RESEARCH ARTICLE published: 11 December 2013

    Engineering Websites

    Chesler, Naomi C.

    of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice Shivendra G. Tewari1 , Scott M. Bugenhagen1Su) to induce pulmonary hypertension. Data on right ventricular pressure and volume, and systemic arterial by pathological remodeling of the right ventricle in HySu-induced pulmonary hypertension. Keywords: pulmonary

  16. Recent studies have demonstrated that limitations to oxygen transport in lizards occur within both the respiratory and

    Environmental Sciences and Ecology Websites

    Bennett, Albert F.

    both the respiratory and cardiovascular systems. The lateral flexions of the trunk that occur during of the main veins in the abdominal compartment. Systemic venous return and ventricular preload are major (heart rate, mean arterial blood pressure, central venous pressure, venous return) and respiratory

  17. Reprint from Handbook of Experimental Pharmacology, Vol. 171

    Biology and Medicine Websites

    Kemnitz, Joseph

    Arrhythmias Editors: Robert S. Kass and Colleen E. Clancy © Springer-Verlag Berlin Heidelberg 2006 Printed cases, triggering catastrophic torsades de pointes arrhythmias and sudden death. More than 200 putative. 1995), an autosomal- dominant disease associated with ventricular arrhythmias and sudden death (Roden

  18. Z .European Journal of Pharmacology 417 2001 131140 www.elsevier.nlrlocaterejphar

    Materials Science Websites

    Parker, Kevin Kit

    of tubulin-binding agents on stretch-induced ventricular arrhythmias Kevin Kit Parker 1 , L. Katherine Taylor with taxol, which polymerizes microtubules. Stretch-induced arrhythmias were produced by transiently .eliciting a stretch-induced arrhythmia increased 0.22"0.11 to 0.62"0.19, ps0.001 in hearts treated

  19. Annals of Biomedical Engineering, Vol. 33, No. 10, October 2005 ( 2005) pp. 13521359 DOI: 10.1007/s10439-005-6806-4

    Engineering Websites

    arrhythmias prompted search for alternative energy sources and means of their application. High applications. Keywords--Cardiac arrhythmia, Langendorff-perfused rabbit hearts preparations, Electrical focal and reentrant ventricular, and especially supraventricular arrhythmias.1,6,25,29,32 RF ablation

  20. PROOF COPY 007704JBO Three-dimensional panoramic imaging of cardiac

    Computer Technologies and Information Sciences Websites

    Grimm, Cindy

    arrhythmias in rabbit heart Fujian Qu Crystal M. Ripplinger Vladimir P. Nikolski Washington University ventricular arrhythmias and the termination of arrhyth- mias by strong electric shocks. Panoramic imaging hearts n=18 during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal

  1. Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart

    Biology and Medicine Websites

    Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart Fujian Qu Crystal M of propagating electrical waves during ventricular arrhythmias and the termination of arrhyth- mias by strong, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto

  2. Phase-2 reentry in cardiac tissue: Role of the slow calcium pulse Inma R. Cantalapiedra,1

    Computer Technologies and Information Sciences Websites

    Politècnica de Catalunya, Universitat

    to underlie many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada.011907 PACS number s : 87.19.Hh, 87.19.R , 05.45. a, 89.75. k I. INTRODUCTION Cardiac arrhythmias and sudden- mias, the causes of lethal arrhythmias are still incompletely understood. A normal heart pumps blood

  3. Common variants at ten loci influence QT interval duration in the QTGEN Study

    Biology and Medicine Websites

    de Bakker, Paul

    factor for sudden cardiac death and drug-induced arrhythmias. We conducted a meta-analysis of three-induced arrhythmias. Sudden cardiac death (SCD) and drug-induced ventricular arrhythmia, a key barrier to drug of myocardial repolarization time, is a risk factor for drug-induced arrhythmias and SCD. Continuous QT interval

  4. Result: Pacemakers drift to attractors Integral of the excitation variable u along

    Biology and Medicine Websites

    Utrecht, Universiteit

    excitable ventricular tissue to study mechano-electrical feedback and arrhythmias Martyn P. Nash1, Rikkert H arrhythmias. Progress in Biophysics and Molecular Biology, 82(1­3): 1­266, 2003. [4] MP Nash & AV Panfilov. Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias. Progress in Biophysics

  5. Measuring the acoustoelectric interaction constant using ultrasound current source density This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    Biology and Medicine Websites

    Witte, Russell S.

    associated with arrhythmias. (Some figures may appear in colour only in the online journal) 1. Introduction Cardiac catheter ablation has evolved to be a standard clinical treatment for arrhythmia. The procedure, consequently, not able to detect non-sustained arrhythmias (e.g., ventricular tachycardia) (Duru 2002, Markides

  6. THREE DIMENSIONAL PANORAMIC FAST FLUORESCENCE IMAGING OF CARDIAC ARRHYTHMIAS IN THE RABBIT HEART

    Computer Technologies and Information Sciences Websites

    Grimm, Cindy

    THREE DIMENSIONAL PANORAMIC FAST FLUORESCENCE IMAGING OF CARDIAC ARRHYTHMIAS IN THE RABBIT HEART the dynamics of propagating waves of excitation during ventricular arrhythmia and defibrillation. However, epicardial pacing, and arrhythmias. The reconstructed 3D electrical activity provides us with a powerful tool

  7. RESEARCH PAPER The anti-protozoal drug pentamidine blocks

    Biotechnology Websites

    de Groot, Bert

    of protozoal infections. Pentamidine treatment may cause sudden cardiac death by provoking cardiac arrhythmias; arrhythmia; molecular modelling Abbreviations: AP, action potential; ATS1, Andersen-Tawil syndrome; HEK-Tawil syndrome (ATS1) characterized by ventricular arrhythmias, periodic paralysis and dysmorphic features

  8. Journal of Fish Biology (2013) 82, 21042112 doi:10.1111/jfb.12120, available online at wileyonlinelibrary.com

    Environmental Sciences and Ecology Websites

    Hinch, Scott G.

    2013-01-01

    at wileyonlinelibrary.com Low cardiac and aerobic scope in a coastal population of sockeye salmon Oncorhynchus nerka Oncorhynchus nerka had a lower aerobic and cardiac scope compared with interior populations with more are characterized by a greater aerobic scope, larger relative ventricular mass with an enhanced coronary supply

  9. DownloadedBy:[UniversiteitMaastricht]At:13:0216May2007 FULL LENGTH RESEARCH ARTICLE

    Engineering Websites

    in the heart requires gap junctions. In mammalian ventricular myocytes these consist of connexin43 (Cx43, phylogeny, hibernation Database accession number: DQ833440 Introduction Connexins are transmembrane proteins in which body temperatures can drop well below 58C, and (iii) species undergoing daily bouts of torpor

  10. 3.3 PUBLICATIONS Gan, Z.,W. Wong and J. J. Liou, Semiconductor Process Reliability in Practice, McGraw-Hill,

    Computer Technologies and Information Sciences Websites

    Hua, Kien A.

    /antenna integration up to 1000oC," IEEE Antennas and Wireless Propagation Letters, Vol. 11, 2012, pp. 369-372. 4. Dong. #12;8. Faragallah, G., Y. Wang, E. Divo and M. A. Simaan, "A New Control System for Left Ventricular. Bricout, Z. Wang, and A. Behal, "How Autonomy Impacts Performance and Satisfaction: Results from a Study

  11. Kcne3 deletion initiates extracardiac arrhythmogenesis in mice

    University of California eScholarship Repository

    2014-01-01

    3=. Real-time qPCR analysis was performed using the CFXreal-time qPCR, echo- and electro- cardiography, ventricular myocyte patch-clamp, coronary artery ligation/reperfusion, blood analysis,real-time qPCR) in colon, 4 chambers of the heart, and adrenal glands of female and male Kcne3 ?/? mice, with similar analysis

  12. 1654 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 52, NO. 10, OCTOBER 2005 Nonlinear Conductance-Volume Relationship for

    Computer Technologies and Information Sciences Websites

    Conductance-Volume Relationship for Murine Conductance Catheter Measurement System Chia-Ling Wei*, Member Abstract--The conductance catheter system is a tool to deter- mine instantaneous left ventricular volume of a linear conductance-volume relationship. The electric field generated by a conductance catheter

  13. Sox6 Up-Regulation by Macrophage Migration Inhibitory Factor Promotes Survival and Maintenance of Mouse

    Biotechnology Websites

    is expressed in the ventricular zone of the ganglionic eminence (GE) of mouse brains at embryonic day 14.5 (E14.5), cultured NSPCs from E14.5 GE, and NSPCs in the subventricular zone (SVZ) around the lateral ventricle (LV

  14. Study of Pressure Estimation for a Human Circulatory System with a LVAD

    Engineering Websites

    Wu, Yi

    Study of Pressure Estimation for a Human Circulatory System with a LVAD Yi Wu1 , Paul Allaire2. Based on the state space model of human circulatory system, the mean aortic pressure can be estimated-invasive evaluation of left ventricular function and properties of human circulatory system. Keywords: Cardiovascular

  15. Ultra-Fast Absorption of Amorphous Pure Drug Aerosols Via Deep Lung Inhalation

    Biotechnology Websites

    Rabinowitz, Joshua D.

    . A promising means of accelerating drug action is through rapid systemic drug administration via deep lung absorption from the lung into the systemic circulation, with peak left ventricular concentrations achieved through the systemic circulation. Thus, a rapid means of delivering drugs into the arterial circulation

  16. Proceedings IEEE ICCV 1995, Pages 687-692 1 A Model-Based Integrated Approach to Track Myocardial

    Biology and Medicine Websites

    Duncan, James S.

    Proceedings IEEE ICCV 1995, Pages 687-692 1 A Model-Based Integrated Approach to Track Myocardial Engineering, Diagnostic Radiology, and Medicine Yale University, New Haven, CT 06520-8042 xship improvement in patient treatment. We present a new method of es- timating left ventricular deformation which

  17. ISSN: 1524-4571 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online

    Materials Science Websites

    Parker, Kevin Kit

    such as translation or signal- ing pathways contribute to regulation of muscle growth during cardiac organo muscle myocytes. We engineered the shape of neonatal rat ventricular myocytes by culturing them of contraction could be dis- tinctly engineered. These data suggest that physical con- strainment of muscle cells

  18. Myofibrillar Architecture in Engineered Cardiac Myocytes

    Biology and Medicine Websites

    Chen, Christopher S.

    such as translation or signal- ing pathways contribute to regulation of muscle growth during cardiac organo in cardiac muscle cells. This is important because the mecha- nisms that regulate muscle growth muscle myocytes. We engineered the shape of neonatal rat ventricular myocytes by culturing them

  19. Olutola Jonah, Stavros V. Georgakopoulos and Shun Department of Electrical and Computer Engineering

    Engineering Websites

    Tentzeris, Manos

    States Abstract--The wireless powering efficiency of the Strongly Coupled Magnetic Resonance (SCMR electrical simulators (FES), left ventricular assist devices (LVAD) [1], artificial hearts, bladder. All systems are designed to operate at 39 MHz. (a) (b) (c) Fig. 1.Models of three wireless powering

  20. UNIVERSITE MONTPELLIER II Dpartement des Sciences Mathmatiques

    Engineering Websites

    Mendez, Simon

    such as Ventricular Assist Devices or artificial hearts. The long-term objective is the optimization of such devices typical of an actual artificial organ such as the Carmat heart. The post-doctoral fellow will be part. 2014). Computing the hemodynamics of artificial hearts is quite challenging, as such devices combine

  1. Copyright by ICR Publishers 2012 Background and aim of the study: The study aim was

    Biology and Medicine Websites

    Kheradvar, Arash

    the saddle annulus motion of the mitral valve was developed. A series of computational analyses and in that the interaction between the leaflet and the ventricular results in fundamentally distinct transmitral vortex formation patterns. Conclusion: Motion of the mitral saddle annulus along with the leaflet length

  2. Am. J. Hum. Genet. 69:13781384, 2001 A Missense Mutation in a Highly Conserved Region of CASQ2 Is

    Biology and Medicine Websites

    Lancet, Doron

    of CASQ2 Is Associated with Autosomal Recessive Catecholamine-Induced Polymorphic Ventricular Tachycardia of inheritance have been described: autosomal dominant and autosomal recessive. Mutations in the ryanodine receptor 2 gene (RYR2), which encodes a cardiac sarcoplasmic reticulum (SR) Ca2+ -release channel, were

  3. Kidney International, Vol. 63 (2003), pp. 17851790 Effect of green tea extract on cardiac hypertrophy following

    Biology and Medicine Websites

    Toledo, University of

    2003-01-01

    tea5/6 nephrectomy in the rat. extract in chronic renal failure patients may be warranted.Background. Left ventricular hypertrophy commonly compli- cates chronic renal failure. We have observed species (ROS). Green tea is a sub- Patients with renal failure develop cardiac hypertrophystance

  4. NATURE METHODS | VOL.3 NO.5 | MAY 2006 | 331 CORRESPONDENCE

    Chemistry Websites

    Cai, Long

    . To provide in vivo validation of these findings, we compared the functional effects of car- diac. Echocardiographic data revealed that 1 month after transplanta- tion, left ventricular ejection fraction (a surrogate marker of car- diac contractility) increased from baseline by 9 ± 6% in the non- transduced

  5. Stresses and Strains in the Passive Left Ventricle H. R. Chaudhry

    Mathematics Websites

    Bukiet, Bruce

    and the anisotropy due to muscle fiber orientation have been included. It is observed that circumferential stress decrease as we go from the equatorial region to the apex. Because heart muscles physically have residual. This mechanism is prevented from operating if the ventricular muscle is stretched beyond the optimal actin

  6. JOURNAL OF EXPERIMENTAL ZOOLOGY 290:751758 (2001) 2001 WILEY-LISS, INC.

    Environmental Sciences and Ecology Websites

    Coughlin, David J.

    2001-01-01

    Expression in the Red, White, and Ventricular Muscle of Juvenile Stages of Rainbow Trout FRANCES E. WEAVER, show differences in red muscle contractile properties: parr red muscle has faster kinetics and a faster maximum shortening velocity than smolt red muscle. A developmental reduction in the number of MHC isoforms

  7. Visualization of embryonic neural stem cells using Hes promoters in transgenic mice

    Biology and Medicine Websites

    McConnell, Susan

    Visualization of embryonic neural stem cells using Hes promoters in transgenic mice Toshiyuki stem cells proliferate in the ventricular zone (VZ) and sequentially give rise to both neurons and glial cells in a temporally and spatially regulated manner, suggesting that stem cells may differ from

  8. Transmural Contractile Reserve After Reperfused Myocardial Infarction in Dogs

    Computer Technologies and Information Sciences Websites

    Prince, Jerry L.

    Transmural Contractile Reserve After Reperfused Myocardial Infarction in Dogs Je´ro^me Garot, MD issue for patients with myocardial infarction (MI) and for those with chronic ischemic left ventricular in subendocardial and transmural experimental infarcts. BACKGROUND The relation between segmental LV function

  9. Fractal Analysis of Heart Rate Dynamics as a Predictor of Mortality in Patients

    Physics Websites

    Ventricular Function After Acute Myocardial Infarction Timo H. Ma¨kikallio, MD, Søren Høiber, MD, Lars Køber) func- tion after acute myocardial infarction (AMI). Traditional time- and frequency-domain HR infarction (AMI),1­4 but the utility of various HR variability measurements has not been well de- fined

  10. Jero^me Garot, MD, PhD Joa~o A. C. Lima, MD

    Computer Technologies and Information Sciences Websites

    Prince, Jerry L.

    ventricular MI myocardial infarction 3D three-dimensional 1 From the Department of Medicine, Divi- sion-encoded MR: Comparison with Delayed Contrast-enhanced MR Imaging after Myocardial Infarction Strain, 511.12143 Myocardium, infarction, 511.814 Published online 10.1148/radiol.2332031676 Radiology 2004

  11. ORIGINAL PAPER J. Hansen H. Gesser J. Altimiras

    Environmental Sciences and Ecology Websites

    Altimiras, Jordi

    -loaded contraction requires more oxygen because ventricular myocardium and cross bridges are loaded with higher bridges and a greater end-systolic po- tential energy in the ventricle for a given mechanical work'' (Suga). This study was designed to evaluate the metabolic costs of volume and pressure loading in the isolated heart

  12. Fundamental Performance Assessment of 2-D Myocardial Elastography in a Phased Array

    Engineering Websites

    Konofagou, Elisa E.

    ) canine left-ventricular model, a theoretical framework was previously developed by our group to evaluate the estimation quality of 2-D myocardial elastography using a linear array. In this paper, an ultrasound finite- element (FE) model of the canine left-ventricle [3, 4]. A 2-D convolutional image formation model

  13. Single-heartbeat electromechanical wave imaging with optimal strain estimation using temporally unequispaced acquisition sequences

    Biology and Medicine Websites

    Konofagou, Elisa E.

    ) is a non-invasive, ultrasound-based imaging method capable of mapping the electromechanical wave (EW canine heart in vivo and then to image during ventricular fibrillation. These results indicate how EWI al 2010, Pernot et al 2007) is a non-invasive, ultrasound-based imaging method that can map

  14. Angle-independent strain mapping in myocardial elastography

    Biology and Medicine Websites

    Konofagou, Elisa E.

    , a control and a regionally ischemic, canine left-ventricular models, were used and model states were using ultrasound. Recent studies have used ultrasound to quantify and study local mechanical properties (i.e. strain measured along the axis perpendicular to the face of the ultrasound transducer

  15. The heart of non-crocodilian reptiles has two atria supplying the ventricle from the systemic and pulmonary circulations.

    Environmental Sciences and Ecology Websites

    Altimiras, Jordi

    the cavum pulmonale (CP) while the left and right aortic arches (LAo and RAo, respectively) emerge from and flows across the muscular ridge to enter the CP, while oxygen-rich blood from the left atrium directly at this site by the start of ventricular diastole can be carried to the CP and recirculated into the pulmonary

  16. A Manual of Poultry Diseases. 

    Texas A&M University - TxSpace

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01

    is among the few breeds reported to have early- 10 onset forms of DCM37. Symptoms can include coughing, shortness of breath, exercise intolerance, syncope, cardiac arrhythmias, specifically atrial fibrillation, premature ventricular contractions (PVCs...-optimal oxygenation of tissues lead to arrhythmias, coughing, syncope, ascites, and, in more severe cases, congestive heart failure and sudden death63. Veterinarians typically recognize two distinct clinical stages of DCM. The preclinical stage is highly variable...

  17. Exercise training regulation of extracellular matrix and remodeling in the aging rat heart 

    Texas A&M University - TxSpace

    Kwak, Hyo Bum

    2009-05-15

    in increased collagen accumulation, elevated internal work, heart stiffness and contributes to diastolic or systolic dysfunction and ventricular remodeling (127). However, the precise mechanisms that lead toward increased fibrosis in the aging heart remain... might become more resistant to collagenase degradation with aging (59). Excessive accumulation of collagen in the heart could lead to tissue stiffness, increase the incidence of arrhythmias, disrupt electronic communication between myocytes...

  18. Limit cycles by FEM for a one - parameter dynamical system associated to the Luo - Rudy I model

    CERN Preprints

    Bichir, C?t?lin Liviu; Amuzescu, Bogdan; Nistor, Gheorghe; Popescu, Marin; Flonta, Maria-Luiza; Corlan, Alexandru Dan; Svab, Istvan

    2011-01-01

    An one - parameter dynamical system is associated to the mathematical problem governing the membrane excitability of a ventricular cardiomyocyte, according to the Luo-Rudy I model. Limit cycles are described by the solutions of an extended system. A finite element method time approximation (FEM) is used in order to formulate the approximate problem. Starting from a Hopf bifurcation point, approximate limit cycles are obtained, step by step, using an arc-length-continuation method and Newton's method. Some numerical results are presented.

  19. Entropy Index as a Measure of Heartbeat Irregularity

    Nuclear Theory (arXiv)

    Rudolph C. Hwa

    1998-09-29

    A method is proposed to analyze the heartbeat waveform that can yield a reliable characterization of the structure after only a few pulses. The measure suggested is entropy index that is related to the one found effective in describing chaotic behaviors in a wide variety of physical systems. When applied to the ECG data that include ventricular fibrillation, the index is shown to change drastically within a few pulses. Wavelet analysis is used to exhibit different scaling behaviors in different phases.

  20. Fluid dynamics of heart valves during atrial fibrillation: a lumped parameter-based approach

    CERN Preprints

    Scarsoglio, Stefania; Guala, Andrea; Ridolfi, Luca

    2015-01-01

    Atrial fibrillation (AF) consequences on the heart valve dynamics are usually studied along with a valvular disfunction or disease, since in medical monitoring the two pathologies are often concomitant. Aim of the present work is to study, through a stochastic lumped-parameter approach, the basic fluid dynamics variations of heart valves, when only paroxysmal AF is present with respect to the normal sinus rhythm (NSR) in absence of any valvular pathology. Among the most common parameters interpreting the valvular function, the most useful turns out to be the regurgitant volume. During AF both atrial valves do not seem to worsen their performance, while the ventricular efficiency is remarkably reduced.

  1. Spatiotemporal dynamics of pacing in models of anatomical reentry

    Nonlinear Sciences (arXiv)

    Sitabhra Sinha; David J. Christini

    2001-07-30

    Reentry around non-conducting ventricular scar tissue, which often causes lethal arrhythmias, is typically treated by rapid stimulation from an implantable defibrillator. However, the mechanisms of termination (success and failure) are poorly understood. To elucidate such mechanisms, we studied pacing of anatomical reentry in 1-D and 2-D excitable cardiac media models. Our results suggest that the existence of inhomogeneity in the reentry circuit is essential for pacing termination of tachycardia to be successful. Considering the role of such inhomogeneities may lead to more effective pacing algorithms.

  2. Measurement and interpretation of electrocardiographic QT intervals in murine hearts

    University of Cambridge - Dspace

    Zhang, Yanmin; Wu, JingJing; King, James H.; Huang, Christopher L.-H.; Fraser, James A.

    2014-04-04

    ://www.ajpheart.org H1553 10, Na-pyruvate 2, pH adjusted to 7.4), bubbled with 95% O2/5% CO2 (British Oxygen, Manchester, UK) on a Langendorff system. The KH solution was passed through a 5-?m filter (Millipore, Watford, UK) and warmed to 37°C using a water jacket... of the silver wire was inserted into the micropipette, with which impalements were made close to the midpoint between ventricular apex and base, and connected to a high-input impedance direct-current microelectrode amplifier system (University of Cambridge...

  3. Functional data analytic approach of modeling ECG T-wave shape to measure cardiovascular behavior

    CERN Preprints

    Zhou, Yingchun; 10.1214/09-AOAS273

    2010-01-01

    The T-wave of an electrocardiogram (ECG) represents the ventricular repolarization that is critical in restoration of the heart muscle to a pre-contractile state prior to the next beat. Alterations in the T-wave reflect various cardiac conditions; and links between abnormal (prolonged) ventricular repolarization and malignant arrhythmias have been documented. Cardiac safety testing prior to approval of any new drug currently relies on two points of the ECG waveform: onset of the Q-wave and termination of the T-wave; and only a few beats are measured. Using functional data analysis, a statistical approach extracts a common shape for each subject (reference curve) from a sequence of beats, and then models the deviation of each curve in the sequence from that reference curve as a four-dimensional vector. The representation can be used to distinguish differences between beats or to model shape changes in a subject's T-wave over time. This model provides physically interpretable parameters characterizing T-wave sh...

  4. Mathematical modeling applied to the left ventricle of heart

    CERN Preprints

    Ranjbar, Saeed

    2014-01-01

    Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac architecture, and then study the resulting fibers of activation that propagate through the myocardium. In our paper, we have attempted to create a novel software capable of demonstrate left ventricular (LV) model in normal hearts. Method: Echocardiography was performed on 70 healthy volunteers. Data evaluated included: velocity (radial, longitudinal, rotational and vector point), displacement (longitudinal and rotational), strain rate (longitudinal and circumferential) and strain (radial, longitudinal and circumferential) of all 16 LV myocardial segments. Using these data, force vectors of myocardial samples were estimated by MATLAB software, interfaced in the echocardiograph system. Dynamic orientation contraction (through the cardiac cycle) of every individual myocardial fiber could ...

  5. A pseudo active kinematic constraint for a biological living soft tissue: an effect of the collagen network

    CERN Preprints

    Bourdarias, Christian; Ohayon, Jacques

    2008-01-01

    Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested that the collagen network surrounding the muscular fibers could account for these mechanical behaviors. To test this hypothesis we develop a model for large deformation response of active, incompressible, nonlinear elastic and transversely isotropic living soft tissue (such as cardiac or arteries tissues) in which we include a coupling effect between the connective tissue and the muscular fibers. Then, a three-dimensional finite element formulation including this internal pseudo-active kinematic constraint is derived. Analytical and finite element solutions are in a very good agreement. The numerical results show this wall thickening effect with an order of magnitude compatible with the experimental observations.

  6. Heart-induced movements in the thorax as detected by MRI

    CERN Preprints

    Solberg, Lars Erik; Fosse, Erik; Hol, Per Kristian

    2014-01-01

    In order to provide information for the use of radar in diagnostics a qualitative map of movements in the thorax has been obtained. This map was based on magnetic resonance image sequences of a human thorax during suspended respiration. The movements were measured using two distinct techniques. Segmentation provided measures of aorta dilatation and displacements, and image edge detection indicated other movements. The largest heart movements were found in the anterior and left regions of the heart with in-plane displacements on the order of 1 cm and which caused lung vessels displacements on the order of 2-3mm especially on the left side due to the heart ventricular. Mechanical coupling between the heart and aorta caused aorta displacements and shape distortions. Despite this coupling, aorta dilatations most likely reflected blood pressure variations.

  7. Controlling spatiotemporal chaos in excitable media by local biphasic stimulation

    Nonlinear Sciences (arXiv)

    Johannes Breuer; Sitabhra Sinha

    2004-06-21

    Controlling spatiotemporal chaos in excitable media by applying low-amplitude perturbations {\\em locally} is of immediate applicability, e.g., in treating ventricular fibrillation, a fatal disturbance in the normal rhythmic functioning of the heart. We look at a mechanism of control by the local application of a series of biphasic pulses, i.e., involving both positive and negative stimulation. This results in faster recovery of the medium, making it possible to overdrive the chaos by generating waves with frequency higher than that possible with only positive pulses. This provides the simplest and most general understanding of the effectiveness of biphasic stimulation in controlling fibrillation and allows designing optimal waveshapes for controlling spatiotemporal chaos.

  8. ECG beats classification using waveform similarity and RR interval

    CERN Preprints

    Ka, Ahmad Khoureich

    2011-01-01

    This paper present an electrocardiogram (ECG) beat classification method based on waveform similarity and RR interval. The purpose of the method is to classify six types of heart beats (normal beat, atrial premature beat, paced beat, premature ventricular beat, left bundle branch block beat and right bundle branch block beat). The electrocardiogram signal is first denoised using wavelet transform based techniques. Heart beats of 128 samples data centered on the R peak are extracted from the ECG signal and thence reduced to 16 samples data to constitute a feature. RR intervals surrounding the beat are also exploited as feature. A database of annotated beats is built for the classifier for waveform comparison to unknown beats. Tested on 46 records in the MIT/BIH arrhythmia database, the method shows classification rate of 97.52%.

  9. Indeterminacy of Spatiotemporal Cardiac Alternans

    CERN Preprints

    Zhao, Xiaopeng

    2007-01-01

    Cardiac alternans, a beat-to-beat alternation in action potential duration (at the cellular level) or in ECG morphology (at the whole heart level), is a marker of ventricular fibrillation, a fatal heart rhythm that kills hundreds of thousands of people in the US each year. Investigating cardiac alternans may lead to a better understanding of the mechanisms of cardiac arrhythmias and eventually better algorithms for the prediction and prevention of such dreadful diseases. In paced cardiac tissue, alternans develops under increasingly shorter pacing period. Existing experimental and theoretical studies adopt the assumption that alternans in homogeneous cardiac tissue is exclusively determined by the pacing period. In contrast, we find that, when calcium-driven alternans develops in cardiac fibers, it may take different spatiotemporal patterns depending on the pacing history. Because there coexist multiple alternans solutions for a given pacing period, the alternans pattern on a fiber becomes unpredictable. Usin...

  10. Dynamics of wave fronts and filaments in anisotropic cardiac tissue

    CERN Preprints

    Dierckx, Hans J F M

    2015-01-01

    The heartbeat is mediated between cardiac cells by waves of electrical depolarisation. During cardiac arrhythmias, electrical activity was found to be organised in scroll waves which rotate around a dynamical filament curve. In this thesis, a curved-space approach is used to mathematically capture anisotropy of wave propagation. We derive for the first time the covariant laws of motion for traveling wave fronts and scroll wave filaments in anisotropic excitable media such as cardiac tissue. We show that locally varying anisotropy yields non-zero Riemann tensor components, which may alter the stability of scroll wave filaments. The instability of scroll wave filaments has been linked to transition from ventricular tachycardia to fibrillation.

  11. Vortex formation and instability in the left ventricle

    CERN Preprints

    Le, Trung; Coffey, Dane; Keefe, Daniel

    2011-01-01

    We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging (MRI) data of a healthy human subject. The left ventricular kinematics is modeled via a cell-based activation methodology, which is inspired by cardiac electro-physiology and yields physiologic LV wall motion. In the fluid dynamics videos, we describe in detail the three-dimensional structure of the mitral vortex ring, which is formed during early diastolic filling. The ring starts to deform as it propagates toward the apex of the heart and becomes inclined. The trailing secondary vortex tubes are formed as the result of interaction between the vortex ring and the LV wall. These vortex tubes wrap around the circumference and begin to interact with and destabilize the mitral vortex ring. At the end of diastole, the vortex ring impinges on the LV wall and the large-scale int...

  12. Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions

    CERN Preprints

    Schenone, Elisa; Gerbeau, Jean-Frédéric

    2015-01-01

    This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria. One of the specificities of our approach is to model the atria as a surface, which is the kind of data typically provided by medical imaging for thin volumes. The bidomain equations are considered in their usual formulation in the ventricles, and in a surface formulation on the atria. Two ionic models are used: the Courtemanche-Ramirez-Nattel model on the atria, and the "Minimal model for human Ventricular action potentials" (MV) by Bueno-Orovio, Cherry and Fenton in the ventricles. The heart is weakly coupled to the torso by a Robin boundary condition based on a resistor- capacitor transmission condition. Various ECGs are simulated in healthy and pathological conditions (left and right bundle branch blocks, Bachmann's bundle block, Wolff-Parkinson-White syndrome). To assess the n...

  13. Three-dimensional structure of the flow inside the left ventricle of the human heart

    CERN Preprints

    Fortini, S; Espa, S; Cenedese, A

    2014-01-01

    The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data obtained in vivo. Nevertheless, some questions are still open and new ones stem from the continuous improvements in the diagnostic imaging techniques. Many of these unresolved issues are related to the three-dimensional structure of the left-ventricular flow during the cardiac cycle. In this paper we investigated in detail this aspect using a laboratory model. The ventricle was simulated by a flexible sack varying its volume in time according to a physiologically shaped law. Velocities measured during several cycles on series of parallel planes, taken from two orthogonal points of view, were combined together in order to reconstruct the phase averaged, three-dimensional velocity field. During the diastole, three main steps are recognized in the evolution of the vortical str...

  14. Rate Control Management of Atrial Fibrillation: May a Mathematical Model Suggest an Ideal Heart Rate?

    CERN Preprints

    Anselmino, Matteo; Camporeale, Carlo; Saglietto, Andrea; Gaita, Fiorenzo; Ridolfi, Luca

    2015-01-01

    Background. Despite the routine prescription of rate control therapy for atrial fibrillation (AF), clinical evidence demonstrating a heart rate target is lacking. Aim of the present study was to run a mathematical model simulating AF episodes with a different heart rate (HR) to predict hemodynamic parameters for each situation. Methods. The lumped model, representing the pumping heart together with systemic and pulmonary circuits, was run to simulate AF with HR of 50, 70, 90, 110 and 130 bpm, respectively. Results. Left ventricular pressure increased by 56.7%, from 33.92+-37.56 mmHg to 53.15+-47.56 mmHg, and mean systemic arterial pressure increased by 27.4%, from 82.66+-14.04 mmHg to 105.29+-7.63 mmHg, at the 50 and 130 bpm simulations, respectively. Stroke volume (from 77.45+-8.5 to 39.09+-8.08 mL), ejection fraction (from 61.1+-4.4 to 39.32+-5.42%) and stroke work (SW, from 0.88+-0.04 to 0.58+-0.09 J) decreased by 49.5, 35.6 and 34.2%, at the 50 and 130 bpm simulations, respectively. In addition, oxygen co...