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Sample search results for: auriculo ventricular congenito

 

1

Ventricular torsional relation to ventricular fiber arrangement

  CERN Preprints

Summary: Left ventricular torsion from helically oriented myofibers is a key parameter of cardiac performance. Physicians observing heart motion on echocardiograms, during cardiac catheterization, or in the operating room, are impressed by the twisting or rotary motion of the left ventricle during systole. Conceptually, the heart has been treated as a pressure chamber. The rotary or torsional deformation has been poorly understood by basic scientists and has lacked clinical relevance. The aim of this paper attempts to discuss about this question: Is ventricular twisting related to ventricular fiber arrangement? That is dependent to an assumed model of the left ventricular structure.

Ranjbar, Saeed; Meybodi, Mahmood Emami
2014-01-01

2

Right Ventricular Outflow Tract Reconstruction with Bicuspid Valved Polytetrafluoroethylene Conduit

  Engineering Websites

Summary: of great arteries in one and interrupted aortic arch with a ventricular septal defect in one. In sixteenRight Ventricular Outflow Tract Reconstruction with Bicuspid Valved Polytetrafluoroethylene Conduit available for right ventricular outflow tract (RVOT) reconstruction eventually become stenotic and

Pekkan, Kerem

3

Experimental Measures of Ventricular Activation and Synchrony

  Computer Technologies and Information Sciences Websites

Summary: resynchronization therapy (CRT) for heart failure patients has been reported to be an inconsistent indicator, electrophysiology--basic, CRT, pacing, animal studies Introduction Over the past decade, cardiac resynchroniza- tion therapy (CRT), a ventricular pacing treatment aimed at restoring synchronous contraction of the ventricles

Utah, University of

4

Phase resetting of spontaneously beating embryonic ventricular heart cell aggregates

  Biology and Medicine Websites

Summary: Phase resetting of spontaneously beating embryonic ventricular heart cell aggregates MICHAEL R embryonic ventricular heart cell aggregates. Am. J. Physiol. 251 (Heart Circ. Physiol. 20): Hl298-Hl305 OF A SINGLE premature stimulus to the heart can result in dramatic changes in its rhythmic activity

Guevara, Michael R.

5

Myocardial Energetics in Left Ventricular Hypertrophy

  CiteSeer

Summary: Abstract: The heart carries out its pumping function by converting the chemical energy stored in fatty acids and glucose into the mechanical energy of actin-myosin interaction of myofibrils. Development of congestive heart failure is usually preceded by a period of compensated left ventricular hypertrophy (LVH) and alterations in myocardial bioenergetics have been considered to play an important role in this transition. Myocardial energetic state that is reflected by the ratio of Phosphocreatine to Adenosine Triphosphate (PCr/ATP) is significantly decreased in hearts with LVH. The severity of this abnormality is linearly related to the severity of cardiac hypertrophy as well as left ventricular (LV) dysfunction, and is independent of a persistent myocardial ischemia. The decrease in PCr/ATP is accompanied by a decrease in creatine kinase flux and alterations in substrate utilization in LVH hearts. Moreover, there is a profound heterogeneity in alterations in myocardial energy metabolism in hearts with post-infarction hypertrophy with the most severe abnormality present in the inner layers of the periscar border zone (BZ). This review will discuss various aspects of myocardial energetics in animal models of three different types of LVH (pressure-overload, volume overload and post-infarction) with a brief description of myocardial energetics in humans with LVH.

Mohammad N. Jameel; Jianyi Zhang

6

A novel approach for the diagnosis of ventricular tachycardia based on phase space reconstruction of ECG

  CERN Preprints

Summary: Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to ventricular tachyarrhythmia in patients with and/or without structural heart disease. Ventricular fibrillation (VF) and ventricular tachycardia (VT) are the most common electrical mechanisms for cardiac arrest. Accurate and automatic recognition of these arrhythmias from electrocardiography (ECG) is a crucial task for medical professionals. The purpose of this research is to develop a new index for the differential diagnosis of normal sinus rhythm (SR) and ventricular arrhythmias, based on phase space reconstruction (PSR).

Koulaouzidis, George; Cappiello, Grazia; Mazomenos, Evangelos B; Maharatna, Koushik; Morgan, John
2014-01-01

7

The formation and function of the brain ventricular system

  MIT - DSpace

Summary: The brain ventricular system is composed of a highly conserved set of cavities that contain cerebrospinal fluid (CSF), a protein-rich fluid essential for brain function. However, little is known about the function of ...

Chang, Jessica T. (Jessica Tzung-Min)
2012-01-01

8

Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment

  Biology and Medicine Websites

Summary: Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment Liana), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment Inc. All rights reserved. Keywords: Parkinson disease; Mild cognitive impairment; MCI; Brain atrophy

Thompson, Paul

9

Numerical analysis of Ca2+ signaling in rat ventricular

  Mathematics Websites

Summary: . The transverse-axial t-tubule geometry was derived from light microscopy structural data. To solve the nonlinear-transporting proteins, we analyze several important spatial and temporal features of Ca2+ signaling in rat ventricular

Holst, Michael J.

10

VENTRICULAR FIBRILLATION AND BLOOD CHEMISTRY FROM SINGLE AND MULTIPLE TASERX26 DISCHARGES ON PIGS

  Multidisciplinary Databases and Resources Websites

Summary: VENTRICULAR FIBRILLATION AND BLOOD CHEMISTRY FROM SINGLE AND MULTIPLE TASERX26 DISCHARGES ON PIGS)............................................................................. 17 7.2 Chapter 3 ­ Ventricular fibrillation and blood chemistry after multiple Tasering of pigs

Sheridan, Jennifer

11

A two phase harmonic model for left ventricular function

  CERN Preprints

Summary: A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude and the elastic constant of the oscillator are different. Taking into account the pressure within the left ventricle, the model shows qualitative agreement with functional parameters of the left ventricle. The model allows for a natural explanation of heart failure with preserved systolic left ventricular function, also termed diastolic heart failure. Specifically, the rise in left ventricular filling pressures following increased left-ventricular wall stiffness is attributed to a mechanism aimed at preserving heart rate and cardiac output.

Dubi, S; Dubi, Y
2006-01-01

12

A Novel Mathematical/Numerical Formula for Assessing Right Ventricular Torsion Using Echocardiographic Imaging

  CERN Preprints

Summary: Recently, the ventricular torsional parameters have received special attention because of their significant role in the ventricular systolic and diastolic function. Right ventricular (RV) rotational deformation is a sensitive index for RV performance but difficult to measure. Having assumed RV as a conic shape, the present study serves a novel mathematical formula of right ventricular rotation that uses velocity vector imaging (VVI) for quantifying RV.

Ranjbar, Saeed
2015-01-01

13

Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes with Realistic Transverse Tubules

  Mathematics Websites

Summary: ForReview Only Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes with Realistic, Mathematics TIPS: calcium dynamics, ventricular myocytes, numerical simulation, finite element methods, meshless methods #12;ForReview Only 1 Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes

Holst, Michael J.

14

Original article Marked differences between atrial and ventricular gene-expression remodeling in

  Biology and Medicine Websites

Summary: Fibrosis Congestive heart failure (CHF) causes arrhythmogenic, structural and contractile remodeling-death and fibrosis. The present study assessed time-dependent left atrial (LA) and ventricular (LV) gene of fibrosis, atrial and ventricular dilatation, and impaired ventricular and atrial function, as well as time

Glass, Leon

15

CARDIOMYOPATHY Exercise-Induced Left Ventricular Systolic Dysfunction

  Biology and Medicine Websites

Summary: CARDIOMYOPATHY Exercise-Induced Left Ventricular Systolic Dysfunction in Women Heterozygous women each underwent standard exercise stress echocardiography. Results: Heterozygotes demonstrated.62 6 0.07, P = .02). After exercise, the mean LVEF fell to 0.53 6 0.14 in heterozygotes but rose to 0

Campbell, Kevin P.

16

RESEARCH ARTICLE Open Access Reduced CSF turnover and decreased ventricular

  Physics Websites

Summary: RESEARCH ARTICLE Open Access Reduced CSF turnover and decreased ventricular Ab42 levels are related of Alzheimer's disease, although amyloid deposits also occur in aged non-demented subjects. Ab42 Alzheimer's disease (AD) is characterized by the pre- sence of diffuse and senile dense-core plaques. Senile

Paris-Sud XI, Université de

17

RESEARCH Open Access Automated left ventricular diastolic function

  Computer Technologies and Information Sciences Websites

Summary: % of patients suffering from heart failure have a normal LV ejection fraction while their diastolic function with incipient heart failure. Although this evaluation could be performed from phase-contrast (PC) cardiovascular to the quality of left ventricular (LV) filling, is a source of heart failure: it has been shown that 40 to 50


18

Blood damage measures for ventricular assist device modeling

  Materials Science Websites

Summary: Blood damage measures for ventricular assist device modeling Dhruv Arora1, Marek Behr1 and Matteo challenge that needs to be addressed in the design phase of blood pumps is the elevated level of shear stress, and the hemolysis response of the red blood cells, which depends on both the dose and time

Natelson, Douglas

19

Cardiac conduction and resistanceCardiac conduction and resistance to ventricular fibrillation in Siberianto ventricular fibrillation in Siberian

  Engineering Websites

Summary: Cardiac conduction and resistanceCardiac conduction and resistance to ventricular fibrillation of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability. Efimov 66 The intercalated disk and cardiac gapThe intercalated disk and cardiac gap junction


20

Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using

  Biology and Medicine Websites

Summary: with psoriasis. Main outcome measure Diagnosis of cardiac arrest or ventricular arrhythmia. Results Patients or psoriasis. These conditions were selected because they require periodic prescriptions and are

Hennessy, Sean

21

MULTIVARIATE TENSOR-BASED MORPHOMETRY ON SURFACES: APPLICATION TO MAPPING VENTRICULAR CHANGES IN HIV/AIDS

  Biology and Medicine Websites

Summary: a con- formal parameterization of ventricular geometry, and to reg- ister lateral ventricular surfaces abnormalities. Multivariate Hotelling's T2 statistics on the local Riemannian metric tensors, computed in a log-Euclidean forms and tensor-based morphometry, in the log-Euclidean domain, on the resulting surface tensors. Index

Thompson, Paul

22

Computational Fluid Dynamics Modeling of Impeller Designs for the HeartQuest Left Ventricular Assist Device

  Environmental Sciences and Ecology Websites

Summary: of people suffering from congestive heart failure (CHF) in the United States is estimated to be more than 4Computational Fluid Dynamics Modeling of Impeller Designs for the HeartQuest Left Ventricular,* AND DON B. OLSEN To finalize the design of the next generation of the HeartQuest left ventricular assist

Day, Steven

23

Computer simulation of a novel technique for Radio-Frequency Ablation of ventricular arrhythmias

  MIT - DSpace

Summary: Ventricular Tachycardia (VT) is a rapid arrhythmia, most commonly due to reentrant electrical activity in the heart. A common treatment for VT is Radio-Frequency Ablation (RFA), which is minimally invasive, but requires ...

Rosbury, Tamara S
2006-01-01

24

Progress in Cardiology myosin binding protein C (cMBPC),6 ventricular myosin

  Biology and Medicine Websites

Summary: and charac- terized by mild hypertrophy and a poor prognosis with a high incidence of sudden death before to be associated with a particular phenotype of cardiac hypertrophy defined by mid left ventricular obstruction.7

Lee, Won-Ha

25

A Rare Cause of Heart Failure Treated by Heart Transplantation: Noncompaction of the Ventricular Myocardium

  CiteSeer

Summary: Noncompaction of the ventricular myocardium is a rare cardiomyopathy due to an arrest of myocardial morphogenesis. The characteristic echocardiographic findings are prominent myocardial trabeculations and deep intertrabecular spaces communicating with the left ventricular cavity. The clinical manifestations include heart failure (HF) signs, ventricular arrhythmias, and cardioembolic events. We describe an illustrative case of noncompaction of the ventricular myocardium associated with bicuspid aortic valve, a 42-year-old male presenting a refractory acute heart failure successfully treated by emergency heart transplantation. Copyright © 2009 Julien Bordes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1.

Article Id; Julien Bordes; Rine Imbert; Sami Hraiech; Frédéric Collard; Françoiskerbaul

26

Mechanisms of Ventricular Fibrillation The role of mechano-electrical feedback

  Biology and Medicine Websites

Summary: .1 The Heart . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Cardiac Arrhythmias . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.2.1 Mechanisms of Cardiac Arrhythmias . . . . . . . . . . . . . 5 1.2.2 Mechanisms of Ventricular Fibrillation . . . . . . . . . . . . 6 1.2.3 Cardiac Arrhythmias and Mechano-Electrical Feedback

Utrecht, Universiteit

27

Right ventricular ejection fraction from equilibrium and first pass scintigraphic cardiac images

  Texas A&M University - TxSpace

Summary: Radioactive 2 x 10 years Fig. 6. Generation and transition of Tc 11 2. Radiopharmaceuticals Radiopharmaceuticals or radioactive tracers generally consist of a radionuclide emit- ting 7-rays. They need to allow maximum information extraction... the contraction phase, is an important indicator of ventricular func- tion. Equilibrium images, in which the radiopharmaceutical is uniformly distributed throughout the blood pool, are routinely used to compute the left ventricular ejec- tion fraction...

Nakamura, Eiji
1993-01-01

28

Two forms of spiral-wave reentry in an ionic model of ischemic ventricular Aoxiang Xu and Michael R. Guevara

  Biology and Medicine Websites

Summary: Two forms of spiral-wave reentry in an ionic model of ischemic ventricular myocardium Aoxiang Xu whether spiral waves might be induced in a realistic model of inhomogeneous ventricular myocardium. We and Michael R. Guevara Department of Physiology and Centre for Nonlinear Dynamics in Physiology and Medicine

Guevara, Michael R.

29

MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY-BASED COHORT

  Biology and Medicine Websites

Summary: MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY atrophy patterns may be useful for early disease detection or for patient moni- toring in drug trials. 1 with risk for and progression of dementia and MCI in elderly subjects [1] [3] [5]. There- fore, ventricular

Thompson, Paul

30

Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation

  Nonlinear Sciences (arXiv)

Summary: Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart makes it incapable of any concerted pumping action. Methods of controlling ventricular fibrillation include electrical defibrillation as well as injected medication. Electrical defibrillation, though widely used, involves subjecting the whole heart to massive, and often counterproductive, electrical shocks. We propose a defibrillation method that uses a very-low-amplitude shock (of order mV) applied for a brief duration (of order 100 ms) and over a coarse mesh of lines on our model ventricle.

Sitabhra Sinha; Ashwin Pande; Rahul Pandit
2001-04-04

31

BioSystems 71 (2003) 7180 Reentrant waves in a ring of embryonic chick ventricular cells

  Biology and Medicine Websites

Summary: . This preparation may serve as a useful model system to further investigate complex dynamics arising duringBioSystems 71 (2003) 71­80 Reentrant waves in a ring of embryonic chick ventricular cells imaged in revised form 24 March 2003 Abstract According to the classic model initially formulated by Mines

Glass, Leon

32

Original Research Article Estimation of right atrial and ventricular hemodynamics by

  Engineering Websites

Summary: alternative to the invasive assessment of coronary artery disease. However, a specific limitation of CTCA of estimating right atrial and ventricular pressure. Ó 2011 Society of Cardiovascular Computed Tomography. All noninvasive alternative to the invasive assessment of coronary artery disease. However, a specific limitation

Mittal, Rajat

33

Design and Transient Computational Fluid Dynamics Study of a Continuous Axial Flow Ventricular Assist Device

  Environmental Sciences and Ecology Websites

Summary: in the United States have congestive heart failure (CHF), a clinical syndrome that involves severe ventricular These patients with cardiac failure follow a significant regimen of cardiac medications and often require heart transplantation. Because there is a limited number of donor hearts available each year (approximately 2,500), many

Day, Steven

34

Tornado in a dish: Revealing the mechanisms of ventricular arrhythmias in engineered cardiac tissues

  Engineering Websites

Summary: Editorial Tornado in a dish: Revealing the mechanisms of ventricular arrhythmias in engineered, immediate causes of death in the developed world. Investigation of the mechanisms of VT/VF spans over) that the condition is caused by the re-entry of impulses and the formation of circles of excitation. Each


35

Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

  Biology and Medicine Websites

Summary: Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects and validated a new method to create automated 3D parametric surface models of the lateral ventricles in brain to MRIs from 17 Alzheimer's disease (AD) patients and 13 age- and gender-matched healthy elderly control

Thompson, Paul

36

ARTICLE IN PRESS 3D mapping of ventricular and corpus callosum abnormalities in

  Biology and Medicine Websites

Summary: computational anatomy techniques, we mapped how AIDS impacts the corpus callosum (CC) and ventricular system, two systems that show prominent changes on MRI. We (1) identified regions with greatest differences differences with measures of immune system deterioration and cognitive decline. Methods: 51 3D brain MRI scans

Thompson, Paul

37

Dynamic Stresses and Strains in the Left Ventricular Wall based on Large Deformation

  Mathematics Websites

Summary: Dynamic Stresses and Strains in the Left Ventricular Wall based on Large Deformation Theory H. R)­596­6467) Abstract In this paper, elastodynamic large deformation theory is applied to calculate dynamic stresses to be spherical. We examine the influence the inertial term has on stresses, strains, stretch ratios, wall

Bukiet, Bruce

38

Vocal fold and ventricular fold vibration in period-doubling phonation: Physiological description and aerodynamic

  Computer Technologies and Information Sciences Websites

Summary: and aerodynamic modelinga) Lucie Bailly,b Nathalie Henrich, and Xavier Pelorson Département Parole et Cognition and ventricular areas, the aerodynamic behavior of the laryngeal system is simulated using a simplified physical aerodynamic interaction. Previous experimental in- vestigations dealing with in vitro set

Boyer, Edmond

39

Towards an Atrio-Ventricular Delay optimization assessed by a computer model for Cardiac Resynchronization Therapy

  Computer Technologies and Information Sciences Websites

Summary: for dierent atrio-ventricular delay (AVD) configurations, in the context of cardiac resynchronization therapy hemodynamics of patients undergoing AVD optimization during CRT. Keywords: Heart Failure, Cardiac pacing delay - AVD), and this configuration has been shown to be patient-specific.2 The lack

Boyer, Edmond

40

Temporal evolution for the phase histogram of ECG during human ventricular fibrillation

  Physics Websites

Summary: : 87.19.Hh, 05.45.Tp INTRODUCTION Cardiac arrhythmias are disturbances in the normal rhythm contraction of the cardiac muscle is lost and the mechanical pumping effectiveness of the heart fails. Therefore, the prediction of ventricular fibrillation (VF), which can lead to sudden cardiac death


41

Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function in Dogs

  Engineering Websites

Summary: ; PAH; Ventricular­vascular hemodynamic coupling; Cardiac Magnetic Resonance Imaging; Pulse pressure-text$watermark-text$watermark-text #12;INTRODUCTION Pulmonary arterial hypertension (PAH) is a devastating disease exhibiting fast progression14 and poor prognosis.20,26 PAH originates from increased resistance to blood flow in the small

Chesler, Naomi C.

42

Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function in Dogs

  Engineering Websites

Summary: by noninvasive methods may be possible. Keywords--Pulmonary arterial hypertension, PAH, Ventric- ular hypertension (PAH) is a devas- tating disease exhibiting fast progression14 and poor prognosis.20,26 PAH and right ventricular (RV) function is impaired. In most PAH patients, RV failure is the direct cause

Chesler, Naomi C.

43

Feature selection using support vector machines and bootstrap methods for ventricular fibrillation detection

  Computer Technologies and Information Sciences Websites

Summary: Feature selection using support vector machines and bootstrap methods for ventricular fibrillation, Murcia, Spain a r t i c l e i n f o Keywords: Feature selection Support vector machines Bootstrap on different domain (time, frequency, and time­fre- quency) using machine learning algorithms has been used

Camps-Valls, Gustavo

44

Three-Dimensional Activation Mapping in Ventricular Muscle: Interpolation and Approximation of Activation Times

  Engineering Websites

Summary: of the electrical activity of the heart, either on its surface or within the muscle, a technique known as cardiac of activation on the epicardial and endocardial surfaces of the heart is possible from measurements of electricThree-Dimensional Activation Mapping in Ventricular Muscle: Interpolation and Approximation

MacLeod, Rob S.

45

Pediatric Mechanical Circulatory Support Thermal Analysis of the PediaFlow Pediatric Ventricular

  Engineering Websites

Summary: devices is crucial in avoiding tissue and blood thermotrauma. Ther- mal models of new Maglev ventricular- vection into blood passing through the pump and conduction through surrounding tissue. Coefficients and blood contacting surfaces are estimated based on maximum temperature rise at respective sur- faces

Paden, Brad

46

Validation of a novel catheter guiding method for the ablative therapy of ventricular tachycardia in a phantom model

  MIT - DSpace

Summary: Accurate guidance of an ablation catheter is critical in the RF ablation (RFA) of ventricular tachycardia (VT). With current technologies, it is challenging to rapidly and accurately localize the site of origin of an ...

Hirschman, Gordon B.

47

The effect of myocardial uptake of epinephrine on ventricular fibrillation threshold

  Texas A&M University - TxSpace

Summary: blocker, resulted in a significant decrease in the uptake of tissue EPI at 30 minutes. Immobilization was then employed to determine if similiar effects occured in the conscious rat. Rats were immobilized for 1 hour, stabilized 15 minutes... tested on 5 control group rats. The results of these experiments are shown in Table 1. The effects of a 30 minute infusion of EPI on the ventricular fibrillation threshold are shown in Table 2. Pre-infusion control VFT's were performed in 6 rats...

Hurst, Terry William
1986-01-01

48

Echocardiographic and scintigraphic methods of left ventricular ejection fraction determination in dogs: a comparative study

  Texas A&M University - TxSpace

Summary: to acquire sufficient data. The same applies to dogs with rapid respiratory rates because excessive motion of the thorax results in movement of both the heart and the transducer head. The effects of tranquilization on the LVEF of dogs is uncertain... parameter in cardiology because it is an indicator of myocardial contractility and left ventricular function. Until recently the only methods available for determining the LVEF were invasive, requiring catheterization of the heart. A rapid injection of a...

Steyn, Phillip Franswa
1989-01-01

49

Spiral Turbulence: From the Oxidation of CO on Pt(110) to Ventricular Fibrillation

  Nonlinear Sciences (arXiv)

Summary: We give a brief overview of systems that show spiral patterns and spatiotemporally chaotic states. We concentrate on two physical systems: (1) the oxidation of CO on Pt(110) and (2) ventricular fibrillation in hearts. The equations that have been suggested as simple models for these two different systems are closely related for they are both {\\it excitable media}. We present these equations and give a short summary of the phenomena they yield.}

Ashwin Pande; Sitabhra Sinha; Rahul Pandit
2000-01-27

50

Dilatation of the Great Arteries in an Infant with Marfan Syndrome and Ventricular Septal Defect

  CiteSeer

Summary: Copyright © 2011 L. Rozendaal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We describe an infant presenting with contractures of the fingers, a large ventricular septal defect (VSD), and severe pulmonary artery dilatation. He had clinical and echocardiographic features of both neonatal or infantile Marfan syndrome (MFS) and congenital contractural arachnodactyly. After surgical VSD closure, the aortic root developed progressive dilatation while the size of pulmonary artery returned to normal limits. Eventually the diagnosis of MFS was confirmed by DNA analysis. 1.

Article Id; L. Rozendaal; N. A. Blom; Y. Hilhorst-hofstee; A. D. J. Tenharkel

51

MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY-BASED COHORT

  Computer Technologies and Information Sciences Websites

Summary: MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY of the cerebral ventricles with risk for and progression of dementia and MCI in elderly subjects [1] [3] [5 been proposed as a possible biomarker for estimating dementia risk or response to treatments. However


52

Abstract--The purpose of this study, was to asses whether LF/(LF+HF) obtained from ventricular repolarization

  Physics Websites

Summary: repolarization variability (VRV) reflects the state of sympathovagal balance. The VRV time series and Heart Rate of the ventricular repolarization (VRV) and heart rate variability (HRV). Peaks in the low frequency (LF) and high to heart rate power spectrum. Generally, LF/(LF+HF)HRV is higher than 0.5 and LF/(LF+HF)VRV is smaller than

Paris-Sud XI, Université de

53

Development and construction of an active mock circulation loop (MCL) for the evaluation of ventricular assist devices (VAD)

  Energy Storage, Conversion and Utilization Websites

Summary: circulatory system for evaluation of ventricular assist devices. Methods Based on the requirements definedDevelopment and construction of an active mock circulation loop (MCL) for the evaluation the evaluation of VAD prototypes and their control algorithms. The MCL is an important tool for the development

Berlin,Technische Universität

54

Prognostic Significance and Normal Values of 2D Strain to Assess Right Ventricular Systolic Function in Chronic Heart Failure

  Physics Websites

Summary: Function in Chronic Heart Failure Short Title: RV dysfunction and prognosis in CHF Soulef Guendouz, MD1 Journal 2012;76(1):127-36" #12;2 ABSTRACT Aims: Chronic heart failure (CHF) has a poor prognosis. Our aims or emergent transplantation or emergent ventricular assist-device implantation or acute heart failure. RV-2D

Paris-Sud XI, Université de

55

doi:10.4061/2011/495349 Review Article Left Ventricular Hypertrophy: Major Risk Factor in Patients with Hypertension: Update and Practical Clinical Applications

  CiteSeer

Summary: Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Left ventricular hypertrophy is a maladaptive response to chronic pressure overload and an important risk factor for atrial fibrillation, diastolic heart failure, systolic heart failure, and sudden death in patients with hypertension. Since not all patients with hypertension develop left ventricular hypertrophy, there are clinical findings that should be kept in mind that may alert the physician to the presence of left ventricular hypertrophy so a more definitive evaluation can be performed using an echocardiogram or cardiovascular magnetic resonance. Controlling arterial pressure, sodium restriction, and weight loss independently facilitate the regression of left ventricular hypertrophy. Choice of antihypertensive agents may be important when treating a patient with hypertensive left ventricular hypertrophy. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers followed by calcium channel antagonists most rapidly facilitate the regression of left ventricular hypertrophy. With the regression of left ventricular hypertrophy, diastolic function and coronary flow reserve usually improve, and cardiovascular risk decreases. 1.

Richard E. Katholi; Daniel M. Couri

56

Abnormal heart rhythms, notably atrial and ventricular fibrillation, are leading causes of death and disability. Between 0.5 million and 1 mil-

  Chemistry Websites

Summary: for atrial fibrillation comprise either symp- tomatic control by decreasing the heart rate during episodes as a `trigger'. Triggeredrhythmsarecommonlysubdividedintothoseoccurringwhen the antecedent heart rate is slowAbnormal heart rhythms, notably atrial and ventricular fibrillation, are leading causes of death

Cai, Long

57

Characterization of two distinct depolarization-activated K ? currents in isolated adult rat ventricular myocytes

  CiteSeer

Summary: ABSTRACT Depolarization-activated outward K + currents in isolated adult rat ventricular myocytes were characterized using the whole-cell variation of the patch-clamp recording technique. During brief depolarizations to potentials positive to-40 mV, Ca2+-independent outward K ÷ currents in these cells rise to a transient peak, followed by a slower decay to an apparent plateau. The analyses completed here reveal that the observed outward current waveforms result from the activation of two kinetically distinct voltage-dependent K + currents: one that activates and inactivates rapidly, and one that activates and inactivates slowly, on membrane depolarization. These currents are referred to here as/to (transient outward) and I s (delayed rectifier), respectively, because their properties are similar (although not identical) to these K ÷ current types in other cells. Although the voltage dependences of Ito and I s activation are similar, /to activates = 10-fold and inactivates ~30-fold more rapidly than I s at all test potentials. In the composite current waveforms measured during brief depolarizations, therefore, the peak current predominantly reflects Ito, whereas I s is the primary determinant of the plateau. There are also

Michael Apkon; Jeanne M. Nerbonne
1991-01-01

58

Differential modulation of proliferation in the neocortical ventricular and subventricular zones

  CiteSeer

Summary: Recent studies have implicated the classical neurotransmitters GABA and glutamate in the regulation of neural progenitor proliferation. We now show that GABA and glutamate have opposite effects on the two neural progenitor populations in the ventricular zones (VZs) and subventricular zones (SVZs) of the embryonic cerebrum. Application of either molecule to organotypic slice cultures dramatically increases proliferation in the VZ by shortening the cell cycle, whereas proliferation in the SVZ is decreased. These disparate effects, measured both by bromodeoxyuridine uptake and the expansion of retrovirally labeled progenitor clones, are mimicked by the application of specific GABA and glutamate agonists and are blocked by antagonists. Thus, the relative contributions of the VZ and SVZ to neocortical growth may be regulated by differential responsiveness to GABA and glutamate. Key words: neurogenesis; neurotransmitter; progenitor; cell cycle; cerebral cortex; corticogenesis Differences in neural progenitor cell proliferation may underlie the variations in cortical size between species as well as some of the neocortical malformations that are present in various neuropathological conditions (Rakic, 1988; Haydar et al., 1999b; Walsh, 1999). Both cell-intrinsic and-extrinsic factors contribute to changes in cell production and affect cerebral cortical growth. Recently, several extracellular molecules, such as growth factors and neurotransmitters, have been implicated in the extrinsic regulation of cell proliferation in the developing telencephalon (for review, see Cameron et al., 1998). For example, basic fibroblast growth factor (bFGF), when added either to cultured cells or microinjected into embryonic brains, prolongs the proliferation of cortical progenitors, leading to increases in the numbers of cortical neurons (Gensburger

Tarik F. Haydar; Feng Wang; Michael L. Schwartz; Pasko Rakic
2000-01-01

59

J. Gorcsan, S. Mulukutla, H. Wang, D. Jacques, G. Stetten, A. Feldman, "Measurement of Left Ventricular Wall Motion Asynchrony in Patients with Left Bundle Branch Block Using Tissue

  Biology and Medicine Websites

Summary: Ventricular Wall Motion Asynchrony in Patients with Left Bundle Branch Block Using Tissue Doppler in Patients with Left Bundle Branch Block Using Tissue Doppler Echocardiography John Gorcsan III, Suresh. To test the hypothesis that tissue Doppler echocardiography may provide a noninvasive means to quantify LV

Stetten, George

60

Case Report Catheter Ablation of Hemodynamically Unstable Ventricular Tachycardia in a Patient with Dextro- Transposition of the Great Arteries and Mustard's Repair

  CiteSeer

Summary: Introduction: A patient with D-TGA and surgical repair (Mustard's procedure) presented with appropriate ICD shocks due to monomorphic ventricular tachycardia, refractory to antiarrhythmic medications Methods and Results: The patient underwent an electrophysiological study and catheter ablation for the VT. Substrate and pace mapping techniques, with the help of an

Divakaramenon Mbbs; Carlos A Morillo Md

61

Anomaly of the Left Anterior Descending Coronary Artery Arising from the Right Sinus of Valsalva and Ventricular Septal Defect in Adult: A Rare Case

  CiteSeer

Summary: Anomaly of the left anterior descending (LAD) coronary artery arising from the right sinus of valsalva is frequently seen with tetralogy of Fallot (TOF). The association of the LAD coronary artery with ventricular septal defect (VSD) is uncommon. We described an anomalous origin of the LAD coronary

Orhan Tacar; Aziz Karadede

62

Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia

  CiteSeer

Summary: The embryonic ventricular zone (VZ) of the cerebral cortex contains migrating neurons, radial glial cells, and a large population of cycling progenitor cells that generate newborn neurons. The latter two cell classes have been assumed for some time to be distinct in both function and anatomy, but the cellular anatomy of the progenitor cell type has remained poorly defined. Several recent reports have raised doubts about the distinction between radial glial and precursor cells by demonstrating that radial glial cells are themselves neuronal progenitor cells (Malatesta et al., 2000; Hartfuss et al., 2001; Miyata et al., 2001; Noctor et al., 2001). This discovery raises the possibility that radial glia and the population of VZ progenitor cells may be one anatomical and functional cell class. Such a hypothesis predicts that throughout neurogenesis almost all mitotically active VZ cells and a substantial percentage of VZ cells overall

Stephen C. Noctor; Er C. Flint; Tamily A. Weissman; Winston S. Wong; Brian K. Clinton; Arnold R. Kriegstein
2002-01-01

63

ORIGINAL ARTICLE J Cardiovasc Ultrasound 2012;20(1):42-48 Impact of Right Ventricular Apical Pacing and Its Frequency on Left Atrial Function

  CiteSeer

Summary: Background: Right ventricular apical (RVA) pacing induces left ventricular (LV) dyssynchrony, increases the risk of persistent atrial fibrillation in the long term. The aim was to investigate the effects of RVA pacing on left atrial (LA) function, which are unknown. Methods: Echocardiographic evaluation including LV dyssynchrony based on conventional Doppler, tissue Doppler imaging and speckle tracking strain echocardiography was done before and after (12 months) single-chamber ventricular pacemaker implantation in 40 patients with sick sinus syndrome. Patients were divided to 2 groups, according to the RVA pacing frequency (group I had higher pacing rate of more than 50 % and group II, less than 50%). Results: There was no significant difference in LV ejection fraction, however, mean global LV strain, myocardial performance index, and parameters of LV dyssynchrony had shown significant changes after 12 months of RVA pacing. There were also significant increase in the LA volume index and the reduction of peak systolic LA strain and strain rate (SR), peak early and late diastolic SR after RVA pacing. Moreover, there was significant deterioration of LV dyssynchrony and both LA and LV longitudinal function in even group II. LA functional deterioration and LA volume was significantly correlated with the frequency of RVA pacing. Conclusion: LV dyssynchrony, induced by RVA pacing, significantly impaired active LA contraction and passive stretching, and these findings were shown in the patients with even less than 50 % of RVA pacing. Impairment of LA strain/SR was significantly correlated with the frequency of RVA pacing. KEY WORDS: Atrial function · Pacemaker · Dyssynchrony.

unknown authors

64

Please cite this article in press as: Linninger A, et al. An impedance sensor to monitor and control cerebral ventricular volume. Med Eng Phys (2009), doi:10.1016/j.medengphy.2009.03.011

  Biology and Medicine Websites

Summary: CSF Pressure shunts Volume sensor Hydrocephalus a b s t r a c t This paper presents a sensor automatic feedback control system designed to maintain the ven- tricular volume at normal levels of hydrocephalus. The computer analysis predicted voltage drops over the entire range of ventricular size changes

Linninger, Andreas A.

65

Novel Therapeutic Strategy for Ventricular Dysfunction?

  CiteSeer

Summary: Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation Research can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at:

Roger J. Hajjar; Jane A. Leopold; Circ Res

66

Miniaturization of a left ventricular assist device

  Texas A&M University - TxSpace

Summary: assist. The current research reduced the Texas A&M University-Multiple Disk Pump to a convenient size and shape by mounting the motor that powers the pump directly onto the pump housing. The motor profile is very slim as it's length is only one inch while...

Milios, Gregory Scott
1996-01-01

67

UNCORRECTEDPROOF 1 Mapping genetic influences on ventricular structure in twins

  Biology and Medicine Websites

Summary: of the human brain, little 13 is known about the genetic and environmental causes of these variations. Here we developed an automated 14 system to visualize genetic and environmental effects on brain structure in large attributable to (1) genetic differences among subjects, (2) environmental 22 influences unique to each

Thompson, Paul

68

Magnetic Design for the PediaFlow Ventricular Assist Device

  Engineering Websites

Summary: , an actively con- trolled thrust actuator for axial support, and a brushless direct current (DC) motor element analysis (FEA). A toroidally wound motor was designed for high efficiency and minimal additional

Paden, Brad

69

Design and construction of a left ventricular cardiovascular assist device

  Texas A&M University - TxSpace

Summary: of generating flow in excess of 10 liters per minute. 15 The components are fully enclosed in a titanium flow tube that has been hermetically sealed. The pump is driven by a brushless, direct current (DC) motor stator that is contained... per minute 0.597cm 2.608cm 100 Beats per minute 0.358cm 1.56cm Calculation of Pressure Losses Losses in pressure head occur in the line due to obstructions, openings, line losses, etc. These losses act as a load on the motor. Losses...

Vedi, Manmeet Singh
2004-11-15

70

Research Report Corpus callosum morphology and ventricular size in

  Biology and Medicine Websites

Summary: , Belo Horizonte, MG 30535-610, Brazil b M.I.N.D. Institute, University of California, Davis, CA 95817 changes to that structure and to examine their possible effects on cognitive function. The callosal and the structure's boundary and midline were computed automatically. Difference analysis was based on non

Nguyen, Danh

71

Estimation of 3D Left Ventricular Deformation from Echocardiography

  Biology and Medicine Websites

Summary: J. Sinusas 2,3 Donald P. Dione 3 and James S. Duncan 1,2 Yale Image Processing and Analysis Group 06520-8042. U.S.A. 4 Abstract The quantitative estimation of regional cardiac deformation from 3D image. Such estimates have so far been obtained almost exclusively from Mag- netic Resonance (MR) images, specifically

Duncan, James S.

72

Anisotropic Stretch-Induced Hypertrophy in Neonatal Ventricular Myocytes

  Biotechnology Websites

Summary: hypertrophy (Simpson et al., 1995). Cell shape and alignment, cell­matrix adhe- sion, and cell­cell contact synthesis rates (Simpson et al., 1999), promote myo- fibrillogenesis and induce hypertrophy (Sadoshima), and (if the load is too great) induce apoptosis (Anversa et al., 1986). Simpson et al. (1999) reported

Bhatia, Sangeeta

73

Numerical Analysis of Ca2+ Signaling in Rat Ventricular

  Mathematics Websites

Summary: of Bioengineering, University of California San Diego, La Jolla, California, United States of America, 2 Department of Computer Science, University of Wisconsin, Milwaukee, Wisconsin, United States of America, 3 Department of Medicine, University of California San Diego, La Jolla, California, United States of America, 4 Department

Holst, Michael J.

74

Are Nonlinear Ventricular Arrhythmia Characteristics Lost, as Signal Duration Decreases?

  Engineering Websites

Summary: , time-frequency distributions, coherence analysis, and heart rate variability. To insure sufficient are trained to recognize the four cardiac rhythms studied here. This is based on our previous work in heart approach to two popular methods [6] for heart rhythm classification used in implantable devices ­ a heart

Povinelli, Richard J.

75

On two mechanisms of the domain structure of ventricular fibrillation

  Mathematics Websites

Summary: possible to map optically, using voltage sensitive dyes, the electrical activity on the surfaces of cardiac­resolution data, seemingly contradicts the traditional picture of the disorder of fibrillation, based on low

Biktashev, Vadim N.

76

ORIGINAL RESEARCH Progressive right ventricular functional and structural

  Engineering Websites

Summary: of pulmonary arterial hypertension Zhijie Wang1 , David A. Schreier1 , Timothy A. Hacker2 & Naomi C. Chesler1.184 Abstract Right ventricle (RV) dysfunction occurs with progression of pulmonary arterial hypertension (PAH and decreases in the efficiency of RV interactions with the pulmonary vasculature. To test this hypothesis, we

Chesler, Naomi C.

77

The Visualization and Measurement of Left Ventricular Deformation

  Computer Technologies and Information Sciences Websites

Summary: @cs.auckland.ac.nz Abstract While medical progress has been made in the diagnosis and treatment of heart diseases it remains and the prognosis after heart failure is poor. An im- proved understanding of cardiac mechanics might advance the diagnosis and treatment of heart diseases. We have developed a toolkit designed for visualizing biomedical

Goodman, James R.

78

Can Tasers directly cause ventricular fibrillation? J G Webster1

  Multidisciplinary Databases and Resources Websites

Summary: the heart to stop pumping, the blood pressure to decrease near zero, and the subject to faint almost healthy pigs ranged from 53.8 to 74.4 kg. The pigs were anesthetized and intubated. The blood pressure

Sheridan, Jennifer

79

Carbon Monoxide Pollution Promotes Cardiac Remodeling and Ventricular Arrhythmia in Healthy Rats

  Computer Technologies and Information Sciences Websites

Summary: worldwide by outdoor air pollution caused by vehicles and industrial emissions (http://www.who.int; http:// www.infoforhealth.org). Notably, air pollution increases the risk of mortality from cardiovascular investigating the effects of urban air pollution in humans are mainly restricted to epide- miological studies

Boyer, Edmond

80

Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

  University of California eScholarship Repository

Summary: cells exposed to fluid mechanical forces: relevance formechanical stimuli, which is recognized through “stress-sensitive promoter elements”. 85 Hemodynamic forces, such as fluidmechanical stimuli, which is recognized through “stress-sensitive promoter elements”. 85 Hemodynamic forces, such as fluid

Yamazaki, Katrina Go
2009-01-01

81

Three dimensional aspects of re-entry in experimental and numerical models of ventricular

  Mathematics Websites

Summary: of excitation into multiple re-entrant sources. These re-entrant waves may be idealised as spiral waves in two dimensional, and scroll waves in three dimensional excitable media. Optically monitored, simultaneously waves. We show that numerical simulations, even with a simple homogeneous excitable medium, can

Biktashev, Vadim N.

82

Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models

  Biology and Medicine Websites

Summary: of Doctor of Philosophy by Xenophon Papademetris Dissertation Director: James Scott Duncan May 2000 #12. Xenophon Papademetris 2000 The non-invasive quantitative estimation of regional cardiac deformation has images. c Copyright 2000 by Xenophon Papademetris All Rights Reserved #12;Acknowledgments I would first

Duncan, James S.

83

Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models.

  Biology and Medicine Websites

Summary: Models. Xenophon Papademetris 2000 The non-invasive quantitative estimation of regional cardiac of Doctor of Philosophy by Xenophon Papademetris Dissertation Director: James Scott Duncan May 2000 #12;c Copyright 2000 by Xenophon Papademetris All Rights Reserved #12;Acknowledgments I would first like

Duncan, James S.

84

MODELS OF VENTRICULAR FIBRILLATION PROBABILITY AND NEUROMUSCULAR STIMULATION AFTER TASER USE IN HUMANS

  Multidisciplinary Databases and Resources Websites

Summary: ....................................................................................................................................iv DISCLAIMERS ..........................................................................................................................173 Appendix I Detailed process of FE model geometry and mesh generation in PATRAN).......................................................................187 Appendix IV Human echocardiography measurement documents

Sheridan, Jennifer

85

10.1098/rsta.2001.0833 Ventricular brillation: evolution of

  Biology and Medicine Websites

Summary: conditions for self-sustaining activity in this class of models and demonstrated the existence of a critical as advanced three-dimensional computer models of the heart, which have become available in recent years, have that cause this deadly arrhythmia and provide a constructive approach to the development of e¯ cient anti

Utrecht, Universiteit

86

POSTER PRESENTATION Open Access Age-related variations in left ventricular diastolic

  Physics Websites

Summary: doppler echocardiography Alban Redheuil2,1* , Emilie Bollache2 , Golmehr Ashrafpoor1,2 , Eric Bruguière1 Relationship with age and comparison of phase-con- trast-CMR and Doppler-echocardiography derived left with Doppler echo- cardiography (DE). Furthermore, DE diastolic parameters are known to change with aging

Paris-Sud XI, Université de

87

Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy

  Engineering Websites

Summary: of a narrow catalog of the functionally most important genes regulating ion homeostasis. We focused, the gene crucial for Na+ and K+ homeostasis. Thus, our cell- specific molecular profiling defined new with Ca2+ homeostasis and energy metabolism. However, some of the implicated genes may be secondary to ICM


88

A clinical feasibility study of atrial and ventricular electromechanical wave imaging

  Engineering Websites

Summary: of Radiology, Columbia University, New York, New York. BACKGROUND Cardiac resynchronization therapy (CRT) and atrial ablation procedures currently lack a noninvasive imaging modality for reliable treatment planning in the assessment and follow-up of patients undergoing CRT pacing therapy and atrial ablation, with preliminary

Konofagou, Elisa E.

89

MicroRNA analysis of human embryonic stem cell derived cardiomyocytes and neonatal rat ventricular cardiomyocytes

  University of California eScholarship Repository

Summary: Embryonic Stem Cells via Downregulation of Notch1 Signaling. Circulation Research,research effort to develop the means to replace the damaged or dead cardiomyocytes with transplanted cells, such as human Embryonic Stem

Nelson, Brandon John
2007-01-01

90

SURFACE-BASED COMPUTATIONAL ANATOMY TECHNIQUES REVEAL VENTRICULAR AND HIPPOCAMPAL ABNORMALITIES IN ADOLESCENTS

  Biology and Medicine Websites

Summary: IN ADOLESCENTS WITH SCHIZOPHRENIA 1 C.N. Vidal*, 2 J.L. Rapoport, 1 K.M. Hayashi, 1 J.A. Geaga, 1 Y. Sui, 1 T, and CGAS (children's global assessment scale). All subjects were matched for age, height, gender, follow standardized stereotaxic space. One rater, blind to age, gender and diagnosis, delineated the hippocampus

Thompson, Paul

91

POSTER PRESENTATION Open Access The 3d left ventricular geometry integrated

  Physics Websites

Summary: 81 years (55±9 years) and 3) AVS included 12 subjects (75±14 years) with aortic valve stenosis (AVS systolic pressures (PSP) resulting in MWS. For AVS patients, the echocardiographic trans- aortic valve the three subgroups (C1=64±5, C2=66±7, AVS=72±8 %) The signif- icant and gradual elevation in PSP found

Paris-Sud XI, Université de

92

Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat Ventricular Cardiac Myocytes*

  Biology and Medicine Websites

Summary: - sponse to hypoxia as a function of time. Studies using an Adm promoter-luciferase reporter construct) resulted in a significant, time-dependent increase in adrenomedullin mRNA levels. Transfection studies re was identified as the Adm gene. In this study, we have determined that the expression of the Adm gene increases

Wojcik, Edward J.

93

Elevated Strain and Structural Disarray Occur at the Right Ventricular Apex

  Engineering Websites

Summary: ), or elastography, of hearts was used to quantify mechanical strains occurring through a cardiac cycle. Histological, Cardiomyopathy, Structure/ function, Ultrasound, Elastography. ABBREVIATIONS ARVC Arrhythmogenic Right

Konofagou, Elisa E.

94

De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy

  Materials Science Websites

Summary: ) is an inherited heart muscle disease, frequently accompanied by sudden cardiac death and terminal heart failure and found a novel desmin- mutation p.N116S in a patient with ARVC and terminal heart failure, which a cohort of 22 ARVC patients referred to molecular genetic screening in our heart center for mutations

Bielefeld, Universität

95

CME Hippocampal, Caudate, and Ventricular Changes in Parkinson’s Disease with and Without Dementia

  CiteSeer

Summary: Abstract: Parkinson’s disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson’s Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate


96

MULTIVARIATE TENSOR-BASED MORPHOMETRY ON SURFACES: APPLICATION TO MAPPING VENTRICULAR CHANGES IN HIV/AIDS

  Mathematics Websites

Summary: abnormalities. Multivariate Hotelling's T 2 statistics on the local Riemannian metric tensors, computed in a log to common template, constructing morpholog- ical tensor maps such as the Jacobian determinant, torsion

Wang, Yalin

97

Normal and Hydrocephalic Brain Dynamics: The Role of Reduced Cerebrospinal Fluid Reabsorption in Ventricular Enlargement

  Biology and Medicine Websites

Summary: with communicating hydrocephalus. Mathematical brain models were created using the MRI images of normal subjects­structure interaction, Communicating hydrocephalus, Intracranial pressure. INTRODUCTION A more complete understandingNormal and Hydrocephalic Brain Dynamics: The Role of Reduced Cerebrospinal Fluid Reabsorption

Linninger, Andreas A.

98

Cardiac Right Ventricular Segmentation via Point Correspondence Kumaradevan Punithakumar, Michelle Noga, and Pierre Boulanger

  Engineering Websites

Summary: , University of Alberta Department of Computing Science, University of Alberta Abstract-- This study presents and ill- defined borders, and the photometric similarities between the connected cardiac regions such as papillary muscles and heart wall. Further, geometric/photometric models are hard to build from a finite

Alberta, University of

99

P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium

  Biology and Medicine Websites

Summary: , London NW3 2PF, UK c Heart and Lung Transplant Unit, St. Vincent's Hospital, Darlinghurst, NSW, 2010 the two proteins often appeared to be spatially discrete. Western blotting detected four major bands at 45 bands from rat vas deferens. The most prominent band in human left ventricles was at 95 kDa, possibly

Burnstock, Geoffrey

100

Triggered alternans in an ionic model of ischemic cardiac ventricular muscle

  Biology and Medicine Websites

Summary: the periodic drive train during 1:1 rhythm can result in the conversion of 1:1 to 2:2 rhythm. Within ischemic zone. As K o is increased at a fixed pacing cycle length of 400 ms, there is first a transition

Guevara, Michael R.

101

Stresses and Strains in the Left Ventricular Wall Approximated as a Thick Conical Shell

  Mathematics Websites

Summary: was approximated as a spherical shell and the ventricle as a spherical cavity. The solution to the spherical and the ventricle takes on large de­ formations on the order of 50­100% of its initial dimensions [6]. Mirsky [6

Bukiet, Bruce

102

A DYNAMIC PROGRAMMING SOLUTION TO TRACKING AND ELASTICALLY MATCHING LEFT VENTRICULAR WALLS IN CARDIAC CINE MRI

  Computer Technologies and Information Sciences Websites

Summary: , registration, matching 1. INTRODUCTION To determine insufficient blood circulation, the most common cause of heart attacks, short axis blood oxygen-dependent (BOLD) MR images of the LV are used. A six segment

Tsaftaris, Sotirios

103

Artificial muscle technology applied towards treating ischemic mitral regurgitation caused by left ventricular remodeling

  MIT - DSpace

Summary: Ischemic Mitral Regurgitation (MR) affects a large portion of patients suffering from ischemic heart disease. Significant MR develops in one quarter to one third of patients who suffer from ischemic heart disease and doubles ...

Sabourin, Nicaulas A. (Nicaulas Alexandre), 1978-
2004-01-01

104

Impaired Left Ventricular Function in the Presence of Preserved Ejection in Chronic Hypertensive Conscious Pigs.

  Physics Websites

Summary: with heart rate increases, 2) abnormally blunted isovolumic contraction and relaxation responses while ejection remains preserved and no sign of heart failure is present. The evaluation under unloaded systolic from diastolic alterations based on a classic hemodynamic model of the heart [36]. However it has

Paris-Sud XI, Université de

105

Hemodynamic Improvement in Cardiac Resynchronization Does Not Require Improvement in Left Ventricular

  Physics Websites

Summary: and pacing-induced heart failure (n 7), we studied the effects of CRT on LV rotation mechanics in vivo by 3 hemodynamic parameters but did not significantly change the LV rotation or rotation rate. LV torsion, defined by CRT. CRT did not significantly change the LV torsion rate. There was no significant circumferential

Paris-Sud XI, Université de

106

Finding Hidden Patterns in Complex Ventricular Ectopy V Schulte-Frohlinde

  Environmental Management and Restoration Websites

Summary: hours using a temporal reorganization of the data. Our three dimensional rate-dependent histograms show risk. Frequent PVCs are, for example, found in subjects with congestive heart failure. In the RR of 200 subjects with congestive heart failure. Out of these we have initially selected those subjects

Ashkenazy, Yossi "Yosef"

107

Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass

  Chemistry Websites

Summary: -regulated transcripts (false discovery rate (FDR) o5%, relative change 41.5) in the heart that colocalize are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major associated with elevated LVM. We also applied genome-wide QTT analysis to the human heart and observed that

Cai, Long

108

Basic Res Cardiol . Author manuscript Impaired left ventricular function in the presence of preserved ejection in

  Physics Websites

Summary: with 1) the lack of reduction in isovolumic contraction and relaxation durations with heart rate remains preserved and no sign of heart failure is present. The evaluation under unloaded conditions shows alterations based on a[ ] classic hemodynamic model of the heart 36 . However it has to be emphasized

Paris-Sud XI, Université de

109

PointTracked Quantitative Analysis of Left Ventricular Motion from 3D Image Sequences

  Biology and Medicine Websites

Summary: of Electrical Engineering, Diagnostic Radiology, and Medicine Yale University New Haven, CT 06520 shape properties of the my- ocardial surfaces to recover dense field motion from standard three analysis. In addition, a significant level of activity has been performed within the magnetic resonance (MR

Duncan, James S.

110

Multi-Scale Modeling in Rodent Ventricular Myocytes: Contributions of structural and functional heterogeneities to

  Mathematics Websites

Summary: gradient near the cell membrane and a more uniform Ca2+ distribution in the cell interior [1 rapidly along the cell membrane, to reach the vicinity of the sarcoplasmic reticulum (SR) where-tubular system has also longitudinal extensions [9]-[11], [13]. The SR is an entirely intracellular, membrane

Holst, Michael J.

111

Eur Radiol . Author manuscript Relation of the ischaemic substrate to left ventricular remodelling by

  Physics Websites

Summary: XII Val de Marneé , 51 Avenue du Mar chel de Tassigny 94010é Cr teil CEDEX,FRé Service de cardiologie3 for assessment of myocardial area at risk (MAR) and infarct size (IS) in a rabbit model of reperfused myocardial-registered cine and contrast-enhanced CMR and histopathology at day 3 for assessment of MAR and IS (group 1

Paris-Sud XI, Université de

112

Simultaneous Estimation of Left Ventricular Motion and Material Properties with Maximum a Posteriori Strategy

  Biology and Medicine Websites

Summary: Kong University of Science and Technology Clear Water Bay, Kowloon, Hong Kong Abstract In addition with an extended Kalman filter approach. In this paper, we present a new computational strategy for the framework/deformation of the entire myocardium from these sparsely matched points, assumptions must be made about the myocardial

Shi, Pengcheng

113

Hippocampal and Ventricular Differences in 804 ADNI subjects mapped with Multivariate Tensor-Based Morphometry

  Mathematics Websites

Summary: -Based Morphometry Yalin Wang, Yang Song, Yi-Yu Chou, Arthur W. Toga, Paul M. Thompson and the Alzheimer's Disease neuroimaging to map the profile of disease effects on the brain and its clinical correlates. In Alzheimer differences in 804 subjects scanned as part of the Alzheimer's Disease Neuroimaging Initiative (ADNI; 184 AD

Wang, Yalin

114

Hyperbolic Ricci Flow and Geodesic Curve Lifting for Consistent Ventricular Surface

  Mathematics Websites

Summary: , Leslie C. Baxter5 , Eric M. Reiman4 , Richard J. Caselli6 , Yalin Wang1 , and for the Alzheimer's Disease impairment (MCI) subjects from the Alzheimer's Disease Neuroimag- ing Initiative (ADNI), including 71 Banner Alzheimer's Institute and Banner Good Samaritan PET Center, AZ, USA 5 Human Brain Imaging

Wang, Yalin

115

Hippocampal, Caudate, and Ventricular Changes in Parkinson's Disease with and Without Dementia

  Biology and Medicine Websites

Summary: have demonstrated cortical atrophy associated with dementia and in mild cognitive impair- ment in PD statistical maps demonstrated significant left medial and lat- eral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left

Thompson, Paul

116

Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep

  Biology and Medicine Websites

Summary: . A magnetic resonance imaging technique, magnetic resonance diffusion tensor imaging, has been developed to measure myocyte orientation. By using magnetic resonance diffusion tensor imag- ing, this study tested, perfusion fixed in diastole, and underwent magnetic resonance diffusion tensor imaging. Hearts from normal

Duncan, James S.

117

A NEW AUTOMATED TECHNIQUE FOR LEFT-AND RIGHT-VENTRICULAR SEGMENTATION IN MAGNETIC RESONANCE IMAGING

  Biology and Medicine Websites

Summary: on both binary and grayscale images. First, the standard power-law transformation is applied on the image of the ciné-loop sequence. Then, a standard power-law transformation is performed and the ROI is selected, the transformed image is thresholded and the maximum area, which indicates the cavity, is selected. Finally

Konofagou, Elisa E.

118

ARTICLE IN PRESS Mapping hippocampal and ventricular change in Alzheimer disease

  Biology and Medicine Websites

Summary: -two high-resolution MRI scans were acquired from 12 AD patients (age: 68.4 F 1.9 years) and 14 matched Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095). The resulting maps are sensitive to longitudinal changes in brain structure as the disease progresses

Thompson, Paul

119

Ranking the Clinical and Pathological Correlates of Ventricular Expansion Mapped in 804 Alzheimer's

  Biology and Medicine Websites

Summary: alignment method, to automatically segment parametric 3D surface models of the lateral ventricles in brain MRI scans from 184 AD, 391 MCI, and 229 healthy elderly controls. Radial expansion of the ventricles to rank correlates by effect size. Methods: 804 subjects were scanned as part of the Alzheimer's Disease

Thompson, Paul

120

Differences Between Left and Right Ventricular Chamber Geometry Affect Cardiac Vulnerability to Electric Shocks

  Biology and Medicine Websites

Summary: for improving defibrillation efficacy. Keywords ventricles; virtual electrode polarization; reentry; excitable area; arrhythmia induction Defibrillation and cardiac vulnerability to electric shocks are strongly with an electric shock in sinus rhythm and defibrillation are driven by the same mechanisms.1­3 Furthermore, it has


121

Diagnostic accuracy and variability of three semi-quantitative methods for assessing right ventricular systolic function

  Physics Websites

Summary: Received: 1 February 2011 /Revised: 4 April 2011 /Accepted: 27 April 2011 # European Society of Radiology (*) :J. Fares :P.-H. Vivier :V. Lefebvre : J.-N. Dacher Department of Radiology, University Hospital Author manuscript, published in "European Radiology 21, 10 (2011) 2111-20" DOI : 10.1007/s00330

Paris-Sud XI, Université de

122

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system

  University of California eScholarship Repository

Summary: modified bacteriophage M13 in mice: implications for phagelandscape phage. Gene 2004, 43. Paillard F: Bacteriophage:bacteriophage was screened for ligands capable of internalizing into CP epithelial cells by incubating phage


2011-01-01

123

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular

  Biology and Medicine Websites

Summary: ­CSF barrier. The permeability properties of the blood­CSF interface have been studied previously in adult (CSF) barrier, formed by the presence of continuous tight-junctions between adjacent epithelial cells (Brightman & Reese, 1969). The blood­CSF and the blood­brain barriers protect and regulate the internal

Burnstock, Geoffrey

124

Three dimensional aspects of reentry in experimental and numerical models of ventricular

  Mathematics Websites

Summary: electrical activity of the heart has become possible [Gray, Pertsov & Jalife 1998, Witkowski, Leon, Penkoske may show no spiral waves on either surface of the heart muscle (see Fig. 1(b,c)). This difference the wall. (b,c) Snapshots of surface activity in an optical map­ ping experiment with electrically induced

Biktashev, Vadim N.

125

Three-dimensional organisation of re-entrant propagation during experimental ventricular brilation

  Mathematics Websites

Summary: irregular electrical wave activity on the surface of the heart during experimentally induced #12;brillation accurate models. Recently, detailed mapping of the surface electrical activity of the heart has become on either surface of the heart muscle. This di#11;erence between theory and experiment may mean either

Biktashev, Vadim N.

126

Modeling, Estimation and Control of Cardiovascular Systems with A Left Ventricular Assist Device

  Engineering Websites

Summary: of Virginia, Charlottesville, VA 22903 4Utah Artificial Heart Institute, Salt Lake City, UT 84103 Abstract estimation error is small, and that the ab- normal hemodynamic variables of a congestive heart failure heart failure (CHF) patients. Heart disease is the leading cause of death in the Unite States. Nearly 5

Wu, Yi

127

VENTRICULAR MAPS IN 804 SUBJECTS CORRELATE WITH COGNITIVE DECLINE, CSF PATHOLOGY, AND IMMINENT ALZHEIMER'S DISEASE

  Biology and Medicine Websites

Summary: approach is highly automated, and boosts the power of fluid image registration by integrating multiple with cognitive decline, and with accepted measures of pathology detectable in cerebrospinal fluid (CSF). Ideal hundreds to thousands of images without user intervention. Here we used our multi- atlas fluid image

Thompson, Paul

128

Three Dimensional Speckle Tracking Based Strain Imaging Identifies Alterations in Dynamic Left Ventricular Function after Cardiac Surgery

  University of California eScholarship Repository

Summary: outcomes. 1 While open heart surgery with cardiopulmonaryafter cardiac surgery. European heart journal cardiovascularsurgery for aortic insufficiency (Combined). Exclusion criteria were arrhythmias (such as atrial fibrillation), congenital heart

Howard-Quijano, Kimberly
2014-01-01

129

15. Andreu MJ, Dvila JC, Real MA, Guirado S (1996) Intrinsic connections in the anterior dorsal ventricular

  Biology and Medicine Websites

Summary: -Vanderzee E (1995) Efferent connections of the lateral cortex of the lizard Gekko gecko: evidence for separate Gekko gecko studied with Phaseolus vulgaris-leucoagglutinin. J Comp Neurol 285:289­303 18. Martínez

Krubitzer, Leah A.

130

Quantification of Systolic and Diastolic Left Ventricular Twist Using Fourier Analysis of STimulated Echoes (FAST) Magnetic Resonance Imaging

  University of California eScholarship Repository

Summary: scanner (Siemens Healthcare, Erlangen, Germany) and a six element bodyscanner (Siemens Healthcare, Erlangen, Germany) and a six element bodyscanner (Siemens Healthcare, Erlangen, Germany) and a six element body

Reyhan, Meral Leigh
2012-01-01

131

Relation of the ischaemic substrate to left ventricular remodelling by cardiac magnetic resonance at 1.5T in

  Physics Websites

Summary: resonance (CMR) for infarct sizing has been validated in large animals, but studies and follow understood. Measurement of infarct size (IS) by CMR is accurate in large animals [10-12], but these studies-Alfort, France 2 Department of Radiology and 3 Department of Cardiology, University Hospital Henri Mondor

Paris-Sud XI, Université de

132

The accompanying paper (Vaughan-Jones et al. 2002) reported that, in rabbit ventricular myocytes, the apparent

  Biology and Medicine Websites

Summary: inorganic ions like Na+ or K+ . This value of DH app represents the intrinsic mobility of H+ equivalents, the apparent diffusion coefficient for the intracellular H+ ion (DH app) or its ionic equivalent such as OH. The consequence of a low DH app is that a spatially localized intracellular acidosis spreads slowly as a diffusive

Keener, James P.

133

Regional and temporal heterogeneity of postsystolic wall thickening is associated with left ventricular asynchrony in normal and experimental stunned myocardium.

  Computer Technologies and Information Sciences Websites

Summary: with different amplitudes between walls. Tissue Doppler Imaging demonstrated similar pattern in basal, mid performance during cardiac resynchronization therapy [2, 12, 29, 31, 35]. This issue is still debated

Boyer, Edmond

134

Quantification of Left Ventricular Regional Phase Asynchrony in Patients with Left Bundle Branch Block Using Tissue Doppler Echocardiography

  Biology and Medicine Websites

Summary: Block Using Tissue Doppler Echocardiography Suresh Mulukutla, George Stetten, Didier Jacques, John that tissue Doppler (TD) can quantify LV asynchrony, 17 pts with LBBB (11 with heart failure) and 10 normal assessed for motion-correlation between -1 (out of phase) and 1 (in phase) over the cardiac cycle. Mean

Stetten, George

135

Fractal Correlation Properties of R-R Interval Dynamics and Mortality in Patients With Depressed Left Ventricular

  Biology and Medicine Websites

Summary: --Time and frequency domain heart rate (HR) variability measures, along with short- and long-term correlation (fractal assessed from 24-hour Holter recordings in 446 survivors of acute myocardial infarction with a depressed univariate predictors of all-cause mortality. Reduced short-term scaling exponent 1 was the most powerful R


136

Automated patient-specific classification of premature ventricular contractions In this paper, we present an automated patient-specific

  Engineering Websites

Summary: % for differentiating normal, PVC, and other beats. 1. Introduction The morphological and temporal characteristics-hidden layer MLP classifier to achieve 95.16% accuracy in differentiating normal and PVC from other beats over-specific classification system designed for robust and accurate detection of PVC beats. The feature extractor

Gabbouj, Moncef

137

Abstract--We have recently introduced an algorithm for semi-automatic segmentation of the left ventricular wall in

  Biology and Medicine Websites

Summary: Abstract--We have recently introduced an algorithm for semi-automatic segmentation of the left. These include algorithms designed for short-axis [2]­[4] and long-axis images [5], [6], semi-automatic], and temporal averaging [9]. We have recently introduced an algorithm for semi- automatic segmentation of left

Carvalho, João Luiz

138

Phase statistics approach to human ventricular fibrillation Ming-Chya Wu,1,2,3,* Eiichi Watanabe,4,

  Physics Websites

Summary: Analysis, National Central University, Chungli 32001, Taiwan 2 Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan 3 Department of Physics, National Central University, Chungli 32001, Taiwan Systems and Department of Physics, Chung Yuan Christian University, Chungli 32023, Taiwan Received 27 July


139

Effects of Protein Phosphatase and Kinase Inhibitors on Ca2 and Cl Currents in Guinea Pig Ventricular Myocytes

  Biology and Medicine Websites

Summary: Effects of Protein Phosphatase and Kinase Inhibitors on Ca2 and Cl Currents in Guinea Pig of this study was to compare the effects of various protein phosphatase and protein kinase inhibitors, it is not clear whether both of these channels are regulated in concert by protein kinase A (PKA) or whether


140

THE FUNCTIONAL ROLES OF THE LATERAL PYLORIC AND VENTRICULAR DILATOR NEURONS IN THE PYLORIC NETWORK OF THE LOBSTER,

  Biology and Medicine Websites

Summary: and Sciences of Ohio University In partial fulfillment of the requirements for the degree Doctor of Philosophy has been approved for the Department of Biological Sciences and the College of Arts and Sciences of Ohio University Scott L. Hooper Associate Professor of Biological Sciences Leslie A. Flemming Dean

Weaver, Adam Lee

141

EXCELLENTIA CoLumbIA ENgINEErINg 37 rrhythmogenic right ventricular cardiomyopathy (ARVC), which affects one in

  Materials Science Websites

Summary: out how heart cells respond to physical stresses. ARVC can be caused by genetic mutations that affect proteins which link cells together. Huang is testing whether changes in these proteins interfere with how cells stick together and send signals, making the heart less able to withstand the stresses associated

Hone, James

142

QUANTITATIVE GENETIC MODELING OF LATERAL VENTRICULAR SHAPE AND VOLUME USING MULTI-ATLAS FLUID IMAGE ALIGNMENT IN TWINS

  Biology and Medicine Websites

Summary: in large brain MRI databases1 . We applied our multi-template segmentation approach ("Multi-Atlas Fluid on the brain, extending genetic models to spatially detailed, automatically computed, 3D maps. 1. INTRODUCTION causes remain unknown. A first step in distinguishing these effects is to assemble a large database

Thompson, Paul

143

Multiple levels of the single L-type Ca2+ channel conductance in adult mammalian ventricular myocytes

  Engineering Websites

Summary: of Internal Medicine, University of California, Davis Abstract In cardiac muscle, Ca2+ entry through the L on affecting the efficacy of CICR in the cardiac muscle is discussed. Keywords Cardiac; L-type Ca2+ channel; conductance; Ca2+; excitation-contraction coupling INTRODUCTION In cardiac muscle, Ca2+ entry through L

Chen-Izu, Ye

144

Third Report of the California Hospital Outcomes Project (1997): Report on Heart Attack, 1991-1993 Volume 2

  University of California eScholarship Repository

Summary: for congenital ventricular septal defects is included hereseptal defect Ventricular septal defect Central nervousVentricular flutter Cardiac arrest Rupture of chordae tendinae Rupture of papillary muscle Acquired cardiac septal defect

Romano, Patrick S; Luft, Harold S; Rainwater, Julie A
1997-01-01

145

JOURNAL OF LATEX CLASS FILES, VOL. 6, NO. 1, JANUARY 2007 1 A Novel Model-Based 3D+time Left Ventricular

  Engineering Websites

Summary: with the Centre for Image Processing and Analysis, Dublin City University, Dublin 9, Ireland of the heart. MRI produces 3D and 3D+time images of the heart. To diagnose CVD, doctors commonly assess the functionality and cardiac output are used to assist in the assessment of CVD pathologies [3]. To derive these metrics

Whelan, Paul F.

146

Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive Impairment using Multi-Atlas Fluid Image Alignment

  Biology and Medicine Websites

Summary: created expert delineations of the ventricles, as parametric surface meshes, in 6 brain MRI scans. These 6 images and their embedded surfaces were fluidly registered to MRI scans of 80 AD patients, 80 individuals with mild cognitive impairment (MCI), and 80 healthy controls. Surface averaging within subjects greatly

Thompson, Paul

147

Finding Hidden Patterns in Complex Ventricular Ectopy V Schulte-Frohlinde'i2,Y Ashkenazy', PCh Ivanov'13, A Morley-Davies4,L Glass5,

  Materials Science Websites

Summary: pause. The distribution of the PVCs appears random. PVCs (#PVC>5000 in 24 hours). Here, we choose three subjects that show different patterns in their temporal PVC distribution. The sampling rate is 128/s. 3

Stanley, H. Eugene

148

1 Maximizing power to track Alzheimer's disease and MCI progression by LDA-based 2 weighting of longitudinal ventricular surface features

  Mathematics Websites

Summary: 's disease 28 Mild cognitive impairment 29 Biomarker 30 Drug trial 31 Machine learning 32We propose a new trials that use brain maps. 46© 2012 Published by Elsevier Inc. 4748 49 50 51 Introduction 52 Biomarkers Francisco, CA, USA 12 g Dept. of Psychiatry, UC San Francisco, San Francisco, CA, USA 13 h Dept

Wang, Yalin

149

V.N. Biktashev & A.V. Holden ``Reentrant activity and its control by resonant drift in a twodimensional model of isotropic homogeneous ventricular tissue'' Proc Roy Soc

  Mathematics Websites

Summary: NaK + I Na + I bNa + I siNa + I NaCa + I siCa + I bCa ) â?? m = 200(V + 41) 1 \\Gamma exp [\\Gamma0:1(V + 41)] (1 \\Gamma m) \\Gamma 8000 exp [\\Gamma0:056(V + 66)] m â?? h = 20 exp [\\Gamma0:125(V + 75)] (1 \\Gamma h) \\Gamma 2000 1 + 320 exp [\\Gamma0:1(V + 75)] h â?? d = 90(V + 19) 1 \\Gamma exp [\\Gamma(V + 19

Biktashev, Vadim N.

150

Left ventricular strain and strain rate by 2D speckle tracking in chronic thromboembolic pulmonary hypertension before and after pulmonary thromboendarterectomy

  University of California eScholarship Repository

Summary: Doppler velocities have been observed in CTEPH patients [9]. However, previous studiesDoppler imaging of the septum as well [17-19]. A recent study,studies have shown that LV diastolic abnormalities are common in CTEPH. Specifically, “impaired relaxation” transmitral Doppler


2010-01-01

151

Algisyl-LVR™ with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart

  University of California eScholarship Repository

Summary: treatment (Figure S1, supplemental materials). The LV was modeled using a validated myocardial passive andtreatments for heart failure such as surgical ventric- ular restoration (SVR) [12] and passive


2013-01-01

152

Hysteresis and bistability in the direct transition from 1:1 to 2:1 rhythm in periodically driven single ventricular cells

  Biology and Medicine Websites

Summary: a suction electrode in whole-cell recording mode. The cell was then driven with a periodic train of currentHysteresis and bistability in the direct transition from 1:1 to 2:1 rhythm in periodically driven cycle length BCL was sufficiently long, 1:1 rhythm resulted, with each stimulus pulse producing

Guevara, Michael R.

153

Abstract--Two semi-automatic methods for the detection of the left ventricular border in two-dimensional short axis

  Biology and Medicine Websites

Summary: , boundary detection. I. INTRODUCTION HE analysis of two-dimensional echocardiographic images of a complete cardiac cycle is determined. II. DEVELOPMENT A. First Segmentation Method Fig. 1 shows a diagram of ten consecutive frames are selected in a sliding window fashion (Fig. 2), and the optic flow (OF

Carvalho, João Luiz

154

The role of abnormal stress and strain distributions in the initiation and sustainment of ventricular arrhythmias in dogs with aortic stenosis.

  Biology and Medicine Websites

Summary: The role of abnormal stress and strain distributions in the initiation and sustainment and treatment cost annually [1]. HF is clinical ailment that is commonly associated with reduced cardiac output. In patients with AS, the functional cross-area of the outflow tract is greatly reduced due to calcification

Gleeson, Joseph G.

155

Journal of Theoretical Biology 249 (2007) 2945 Rhythms of high-grade block in an ionic model of a strand of regionally

  Biology and Medicine Websites

Summary: , and is often immediately followed by malignant cardiac arrhythmias such as ventricular tachycardia of regionally ischemic ventricular muscle. In addition, in the experimental work, ventricular arrhythmias on the higher-order rhythms that presage reentrant ischemic ventricular arrhythmias. r 2007 Elsevier Ltd. All

Guevara, Michael R.
2007-01-01

156

Fig. 2. (a) Gross pathological slice and (b-d) MR images of ex vivo tissue. Fig. 1. DIR-FSE for collecting interleaved lipid-and water-only data.

  Engineering Websites

Summary: by progressive lipid infiltration in the right ventricular free wall leading to ventricular malfunction and death [1-2]. Black-blood MRI techniques are often used for the non-invasive detection of lipid infiltration

Bilgin, Ali

157

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

  Mathematics Websites

Summary: interval, a measure of cardiac repolarization, predisposes to ventricular arrhythmias and sudden cardiac with an accompanying paper from the QTGEN consortium, identify new candidate genes for ventricular arrhythmias and SCD

Abecasis, Goncalo

158

unknown title

  CiteSeer

Summary: indivíduos saudáveis (10 homens; 35,7 ± 14 anos). Utilizou-se um ecocardiógrafo Vivid 7 e registaram-se os seguintes parâmetros: dimensões ventriculares, volumes e fracção de ejecção ventricular (método de Simpson), velocidades sistólicas e diastólicas do anel

R E S Um O; Detecção Disfunção; Ventricular Esquerda

159

Comparative analysis of Broca's area in hominoids

  University of California eScholarship Repository

Summary: ontogenetic columns and the migration of neuroblasts from the ventricular and subventricular zones into radial columns during development (ontogenetic columns and the migration of neuroblasts from the ventricular and subventricular zones into radial columns during development (

Schenker, Natalie Marie
2007-01-01

160

Focused quanti cation of a belief network using sensitivity analysis

  Computer Technologies and Information Sciences Websites

Summary: ]. As a case study, we selected a belief network that models the clinical pathophysiology of ventricular septal defect (VSD), a congenital heart disease. Three quanti#12;cations were obtained for this network, di#11 Ventricular s

Utrecht, Universiteit

161

doi:10.1152/ajpheart.00683.2004 289:H398-H413, 2005. First published 11 February 2005;Am J Physiol Heart Circ Physiol

  Engineering Websites

Summary: Schaffer, Anne D. Skriver, Louise Kold Taylor, of embryonic chick ventricular cells An ionic model.physiology.orgDownloadedfrom #12;An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells Trine of embryonic chick ventricular cells. Am J Physiol Heart Circ Physiol 289: H398­H413, 2005. First published

Vetter, Frederick J.

162

289:398-413, 2005. First published Feb 11, 2005; doi:10.1152/ajpheart.00683.2004AJP -Heart Brigitte Pelzmann, Bernd Koidl and Michael R. Guevara

  Biology and Medicine Websites

Summary: , Louise Kold Taylor, of embryonic chick ventricular cells An ionic model for rhythmic activity in small.physiology.orgDownloadedfrom #12;An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cells Trine of embryonic chick ventricular cells. Am J Physiol Heart Circ Physiol 289: H398­H413, 2005. First published

Guevara, Michael R.

163

Predictive Probabilistic Models for Treatment Planning in Paediatric Cardiology

  Computer Technologies and Information Sciences Websites

Summary: ­ cuss the problem of clinical treatment planning for chil­ dren with a ventricular septal defect Ventricular septal defect (VSD) is a relatively well­ understood cardiac anomal. As a case study we have selected the relatively frequent occurring cardiac anomaly of ventricular septal

Utrecht, Universiteit

164

Predictive Probabilistic Models for Treatment Planning in Paediatric Cardiology

  Computer Technologies and Information Sciences Websites

Summary: - cuss the problem of clinical treatment planning for chil- dren with a ventricular septal defect Ventricular septal defect VSD is a relatively well- understood cardiac anomaly with many clinical featu. As a case study we have selected the relatively frequent occurring cardiac anomaly of ventricular septal

Utrecht, Universiteit

165

V.N. Biktashev & A.V. Holden "Re-entrant activity and its control by resonant drift in a two-dimensional model of isotropic homogeneous ventricular tissue" Proc Roy Soc

  Mathematics Websites

Summary: V millivolt potential nA nanoampere current K kelvin temperature µS microsiemen conductance µF microfarad - transmembrane voltage, mV · m, h, d, x, f, q, r, fact, fprod - gating variables, 0 . . . 1 · [Na+ ]i, [K+ ]i + IsiK + IbK + INaK + INa + IbNa + IsiNa + INaCa + IsiCa + IbCa) m = 200(V + 41) 1 - exp [-0.1(V + 41

Biktashev, Vadim N.

166

Printed in U.S.A. Copyright © 1999 by The Endocrine Society High Melatonin Concentrations in Third Ventricular Cerebrospinal Fluid Are Not due to Galen Vein Blood Recirculating through the Choroid Plexus*

  CiteSeer

Summary: MELATONIN, the principal substance secreted by the pineal gland, has been implicated in a number of physiological functions. These include, among others, mood, sleep, circadian rhythms, the immune system, and reproduction (1, 2). In seasonally breeding mammals, there is unequivocal evidence that

Donal C. Skinner; Benoît Malpaux
1999-01-01

167

Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ Res 2005;97:418–426

  CiteSeer

Summary: Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation Research can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at:


168

Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy?

  CiteSeer

Summary: Abstract. We examined the activation of the p38 mitogen-activated protein kinase (p38-MAPK) pathway by the G protein–coupled receptor agonists, endothelin-1 and phenylephrine in primary cultures of cardiac myocytes from neonatal rat hearts. Both agonists increased the phosphorylation (activation) of p38-MAPK by ?12-fold. A p38-MAPK substrate, MAPK-activated protein kinase 2 (MAPKAPK2), was activated approximately fourfold and 10 ?M SB203580, a p38-MAPK inhibitor, abolished this activation. Phosphorylation of the MAPKAPK2 substrate, heat shock protein 25/27, was also increased. Using selective inhibitors, activation of the p38-MAPK pathway by endothelin-1 was shown to involve protein kinase C but not G i/G o nor the extracellularly responsive kinase (ERK) pathway.

Angela Clerk; Ashour Michael; Peter H. Sugden; B Lee

169

The role of caveolin-associated microdomains in adult cardiac myocytes : cAMP and cytoskeletal assembly

  University of California eScholarship Repository

Summary: et al. Cardiac muscle cell hypertrophy and apoptosis inducedmuscle but the animals have abnormal cardiac function, including an enlarged right ventricular cavity, decreased systolic function, myocyte hypertrophy,

Head, Brian P.
2005-01-01

170

Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture

  Materials Science Websites

Summary: capillaries, nerve networks, fibroblasts, ventricular sinuses, cleavage planes and extracellular protein these structural changes are causative or correlative with contractile function and dysfunction. Tissue engineered

Parker, Kevin Kit

171

Reprint from J.L. Wu, K. Ito, S. Tobimatsu, T. Nishida, H. Fukuyama (Eds.)

  Computer Technologies and Information Sciences Websites

Summary: . Introduction To better understand the mechanisms of fatal arrhythmias, we had previ- ously developed, and also had visualized the various elec- trophysiological phenomena of arrhythmias in our ventricular

Igarashi, Takeo

172

doi:10.1152/ajpheart.01300.2005 291:H184-H192, 2006. First published 24 February 2006;Am J Physiol Heart Circ Physiol

  Engineering Websites

Summary: -energy defibrillation shock is the only therapy for ventricular tachyarrhythmias. However, be- cause of adverse side effects, lowering defibrillation energy is desir- able. We investigated mechanisms of unpinning


173

Second Report of the California Hospital Outcomes Project (1996): Acute Myocardial Infarction Volume Two: Technical Appendix-Chapter007

  University of California eScholarship Repository

Summary: Hypertension Hypotension Infarction site Anterior wall Inferior wall Other Paroxysmal ventricular tachycardia Prior coronary artery bypass graft Pulmonary edema Renal failure,Hypertension Infarction site Anterior wall Inferior wall Other Mitral valve disorders Paroxysmal ventricular tachycardia Prior coronary artery bypass graft Pulmonary edema Renal failure,

Romano, Patrick S; Remy, Linda L; Remy, Harold S
1996-01-01

174

Luo W, Gallagher M, Wiles J. Parameter-free search of time-series discord. JOURNAL OF COMPUTER SCIENCE AND TECHNOLOGY 28(2): 300310 Mar. 2013. DOI 10.1007/s11390-013-1330-8

  Computer Technologies and Information Sciences Websites

Summary: ventricular contraction arrhythmia[13] . The presence of arrhythmia is reflected in the time series discord segment for a patient with premature ventricular contraction arrhythmia. The anomalous subsequence circled indicates the presence of the arrhythmia. Regular Paper Support by Australian Research Council Linkage Grant

Gallagher, Marcus

175

The rule of bigeminy revisited: analysis in sudden cardiac death syndrome Claudia Lerma, PhD,a,b

  Physics Websites

Summary: afterdepolarizations. We evaluated these ventricular arrhythmias over extended periods in patients with sudden cardiac on the self-perpetuation of the arrhythmias. Results: Eight (53%) patients had classic torsade de pointes (Td bigeminy (N5% of total ventricular arrhythmias), (2) long corrected QT interval (N0.5 second), (3


176

DOI:10.1111/j.1365-2125.2004.02098.x British Journal of Clinical Pharmacology 2004 Blackwell Publishing Ltd Br J Clin Pharmacol 58:1 8187 81

  Biology and Medicine Websites

Summary: -mail: shenness@cceb.med.upenn.edu Keywords antipsychotic agents, arrhythmia, cohort studies, pharmacoepidemiology the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of ventricular arrhythmia, sudden death, or unexplained or unattended death. Cox regression was used to calculate

Hennessy, Sean

177

Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells

  Biology and Medicine Websites

Summary: ; ventricular zone; progenitor; surface marker; Flk-1; VEGF The vertebrate retina is an excellent model tube-derived structures, the cells abutting the luminal side of the optic cup form a ventricular zone, 1987; McConnell and Kaznowski, 1991). Extrinsic cues influencing progenitors presumably change both

Tabin, Cliff

178

INTRODUCTION The cerebral cortex is crucial for perceptual and higher

  Biology and Medicine Websites

Summary: its formation is completed post- natally under the influence of environmental stimuli, much of its ventricular zone, at the inner surface of the telencephalon, through the overlying intermediate zone of deep layer neurones is determined by cues in the ventricular zone, just prior to final mitotic division

McConnell, Susan

179

154 Am J Psychiatry 161:1, January 2004http://ajp.psychiatryonline.org Brief Report

  Biology and Medicine Websites

Summary: Cortex Christian Gaser, M.E.E., Ph.D. Igor Nenadic Bradley R. Buchsbaum, Ph.D. Erin A. Hazlett, Ph154 Am J Psychiatry 161:1, January 2004http://ajp.psychiatryonline.org Brief Report Ventricular, appear to be impor- tant contributors to ventricular enlargement in schizophrenia. (Am J Psychiatry 2004

Gaser, Christian

180

Three-Dimensional Stress and Strain in Passive Rabbit Left Ventricle: A Model Study

  Biology and Medicine Websites

Summary: --Ventricular mechanics, Scalable parallel computa- tion, Finite element analysis. INTRODUCTION The three. Huyghe et al.19 have developed an axisymmetric quasilinear vis- coelastic finite element FE model and strain distributions in rabbit ventricular myocardium, an anatomically detailed fi- nite element model

Vetter, Frederick J.

181

REENTRANT WAVES INDUCED BY LOCAL BISTABILITIES IN A CARDIAC MODEL

  Biology and Medicine Websites

Summary: and hysteresis have recently been observed to be highly prevalent in periodically stimulated bullfrog ventricular in a bullfrog cardiac preparation [7], and later by Guevara et al. [4] in an aggregate of spontaneously beating local behavior in bullfrog ventricular myocardium, occurring in 74% of preparations studied [8

Bahar, Sonya

182

Orthogonal Basis Expansion based Atrial Activity Reconstruction for Atrial Fibrillation Electrocardiogram Analysis

  Computer Technologies and Information Sciences Websites

Summary: disturbances [1]. AF is characterized by the replacement of consistent P-waves on the ECG by rapid oscillations (fibrillatory waves) that vary in amplitude, frequency, and shape, associated with an irregular ventricular conditions require cancelation of the ventricular activity (QRS complex and T-wave) from the ECG. Due

Abhayapala, Thushara D.

183

Influence of a constriction in the near field of the vocal folds: Physical modeling and experimental validation

  Computer Technologies and Information Sciences Websites

Summary: -singing phonation. This study aims to explore and model the possible aerodynamic interaction between the ventricular ventricular-fold replica in both cases. A theoretical flow modeling is proposed to quantify the aerodynamic: is it related to an acoustical feedback, a mechanical conduction through the laryngeal mucosa, an aerodynamic

Boyer, Edmond

184

doi:10.1016/S0301-5629(03)00952-9 Original Contribution

  Engineering Websites

Summary: of atrial septal defects. These procedures require monitoring of cardiac function, such as cardiac output ventricular biopsy using 3 Fr biopsy forceps. We have also incorporated the 22 Fr probe within a 6-mm surgical, such as left ventricular or biventricular pacing for the treatment of congestive heart failure, have shown

Smith, Stephen

185

Universittsmedizin Gttingen Publikationen und Hochschulschriften 2009

  Biology and Medicine Websites

Summary: septal defect as a post infarction complication. J CARDIOTHORAC SURG, 4: 3. 2. Coskun KO, Popov AF, Coskun ST, Hinz J, Schmitto JD, Körfer R (2009) Surgical treatment of left ventricular aneurysm. Asian (2009) Myocardial ischemia with left ventricular outflow obstruction. J CARDIOTHORAC SURG, 4: 51. 7

Gollisch, Tim

186

Chamber-Specific Cardiac Expression of Tbx5 and Heart Defects in HoltOram Syndrome

  Biology and Medicine Websites

Summary: basis for the prevalence of atrial septal defects (ostium primum and secundum), ventricular muscular pattern of asymmetric (left predominant) upper limb malformations and atrial or ventricular septal defects septal defects, and left-sided malformations (endocardial cushion defects, hypoplastic left heart

Tabin, Cliff

187

The heart of non-crocodilian reptiles has two atria supplying the ventricle from the systemic and pulmonary circulations.

  Environmental Sciences and Ecology Websites

Summary: the CV. During ventricular diastole, oxygen-poor blood from the right atrium (RAt) enters the CV and flows across the muscular ridge to enter the CP, while oxygen-rich blood from the left atrium directly fills the CA. Oxygen-poor blood that remains within the CV by onset of ventricular systole

Altimiras, Jordi

188

Evidence for the Presence of Calsequestrin in Two Structurally Different Regions of

  Biology and Medicine Websites

Summary: reticulum in the A-band region of the cardiac muscle cells . Since chicken ventricular muscle cells lack and relax- ation in mammalian and avian cardiac muscle (1-6). Deter- mination of the subcellular ventricular muscle cells, suggesting that most of the cardiac calsequestrin, like skeletal calsequestrin

Campbell, Kevin P.

189

VOLUME 86, NUMBER 16 P H Y S I C A L R E V I E W L E T T E R S 16 APRIL 2001 Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation

  Physics Websites

Summary: disturbances in the spatiotemporal electrical activation of the heart make it incapable of any concerted the whole heart to massive, and often counterproductive, electrical shocks. We propose a defibrillation hearts [1] and mathemati- cal models [3]. Recent experiments [4,5] have shown that, though VF

Sinha, Sitabhra

190

www.ipej.org 45 Editorial Suppression of Paroxysmal Atrial Fibrillation by Pacing

  CiteSeer

Summary: Atrial Fibrillation (AF) affects approximately five million people world- wide. The incidence of AF increases with aging and more common in males. 1 Atrial fibrillation is the most common cardiogenic cause of stroke and exacerbates heart failure. Despite the prevalence of AF, it is still one of the most difficult arrhythmia to treat. 2 The management option of AF ranges from pharmacological therapy, catheter based ablation and surgery. However, non-traditional uses of pacemaker therapy have been reported in recent past. Pacing therapies for AF are specific to the nature of the patient's AF. 3,4 Pharmacological management alone is the typical initial course of action. In AF cases where rapid ventricular rates cannot be controlled by pharmacological therapy, ventricular pacing therapy may be combined with radiofrequency catheter ablation of AV node. 5 An atrial based pacing mode compared with ventricular pacing, results in better clinical and hemodynamic conditions for patients with ventricular dysfunction. 6 Rosenqvist M et al 7 demonstrated that ventricular based pacing is associated with abnormal activation (e.g., preexcitation) patterns that adversely affect cardiac hemodynamics. Specially, cardiac output and peak ventricular filling rates were found to be significantly lower in ventricular paced groups as

unknown authors

191

Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats

  Biotechnology Websites

Summary: intra-acinar pulmonary arteries, converting it to a neointimal response (28). In this model, rats demonstrate an initial gradual increase in pulmonary arterial and right ventricular systolic pressures (RVSPs

Storey, John D.

192

Pediatric Mechanical Circulatory Support Applications for Frequency-Leveraged Piezoelectric Hydraulic Pumps

  University of California eScholarship Repository

Summary: heart defects include: atrial septal defects (holea patient with an atrial septal defect [7]. As a result, theatrial septum), hypoplastic left heart syndrome (underdeveloped left ventricle), and Tetralogy of Fallot (consists of ventricular septal defect,

Valdovinos, John
2014-01-01

193

Depressive Symptoms and Perceived Doctor-Patient Communication in the Heart and Soul Study

  University of California eScholarship Repository

Summary: diabetes) and disease severity (resting left ventric- ular ejection fraction, exercisediabetes, myocardial infarction, left ventricular ejection fraction ?50%, poor exerciseDiabetes Myocardial infarction Disease severity Resting LVEF, mean ± SD Exercise

Schenker, Yael; Stewart, Anita; Na, Beeya; Whooley, Mary A.
2009-01-01

194

Cell Death and Neuronal Replacement during Formation of the Avian Ciliary Ganglion

  Biology and Medicine Websites

Summary: " was coined to describe the massive loss of intersegmental muscles during insect metamorphosis (Lockshin in the ventricular layer of the neural tube (Blaschke et al., 1996; Homma et al., 1994), and neural hypertrophy

Nishi, Rae

195

Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons

  MIT - DSpace

Summary: During corticogenesis, pyramidal neurons (~80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia[superscript 1], [superscript 2], and then ...

Pinheiro, Elaine M.

196

Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons

  MIT - DSpace

Summary: During corticogenesis, pyramidal neurons (~80% of cortical neurons) arise from the ventricular zone, pass through a multipolar stage to become bipolar and attach to radial glia[superscript 1, 2], and then migrate to their ...

Pinheiro, Elaine M.

197

Naam: dhr. Prof. Dr. Harold V.M. van Rijen Leeropdracht Innovatieve leervormen in het Biomedisch Onderwijs

  Biology and Medicine Websites

Summary: with Dispersed Conduction and Enhanced Susceptibility to Ventricular Arrhythmias. Eur J Heart Fail. 2010 junction proteins under normal and hypertrophic conditions: consequences for action potential conduction: effect on anisotropic and discontinuous conduction' - 2003-2008 : Universitair Docent Medische Fysiologie

Utrecht, Universiteit

198

From Content to Context: The Emergence of the Performance Curator

  University of California eScholarship Repository

Summary: bypass graft- ing (CABG) was performed whenever coronary angiographybypass grafting; CCS: Canadian Cardiovascular Society; COPD: Chronic obstructive pulmonary disease; LVEF: Left ventricular ejection fraction; PTCA: Percutaneous transluminal coronary angiography.

Ferdman, B.
2014-01-01

199

Biomedical Engineering Correlation Between Vortex Ring Formation and Mitral

  Biology and Medicine Websites

Summary: rings that develop during cardiac diastole was initially recognized by in vitro visualization of the ventricular flow5,6 and subsequently confirmed by analyses based on color Doppler mapping7,8 and magnetic

Kheradvar, Arash

200

doi:10.1152/ajprenal.00472.2007 294:450-454, 2008. First published Nov 21, 2007;Am J Physiol Renal Physiol

  Biology and Medicine Websites

Summary: as increases in circulating concentrations of marinobufagenin. Invasive physiological measurements of cardiac ventricular relaxation at 4 wk whereas tissue Doppler imaging de- tected changes in diastolic function after 6

Brand, Paul H.

201

Eur J Heart Fail . Author manuscript The cardiac renin-angiotensin system is responsible for high-salt

  Physics Websites

Summary: Mitogen-Activated Protein Kinases ; metabolism ; Mice ; Mitogen-Activated Protein Kinases ; pharmacology ; physiology ; Sodium, Dietary ; administration & dosage ; Tetrazoles ; pharmacology ; p38 Mitogen-Activated Protein Kinases ; metabolism Author Keywords High salt diet ; Left ventricular hypertrophy ; Blood

Paris-Sud XI, Université de

202

REVIEWS ATLAS OF NEUROPATHOLOGY. By W. Blackwood, M.B., F.R.C.S.E.,

  CiteSeer

Summary: extensive intravascular pulmonary metastases were present. These showed a peculiar tendency to regress, but with widespread involvement of the pulmonary vascular bed, right ventricular hypertrophy and ultimately right heart failure occurred.

unknown authors

203

In This Issue JCB VOLUME 182 NUMBER 6 20081030

  Biology and Medicine Websites

Summary: . The ventricular zone is the developing brain's maternity ward, where stem cells give birth to neurons and other for the developing brain. It could cause the cells to divide at the wrong point in their oscillations, triggering

Brand, Paul H.

204

Coupled Personalisation of Cardiac Electrophysiology Models for Prediction

  Physics Websites

Summary: 1 Coupled Personalisation of Cardiac Electrophysiology Models for Prediction of Ischemic progress in cardiac electrophysiology modelling of the last decades into clinical applications strategy to treat VT. I. Introduction Cardiac arrhythmias including ventricular tachycardia

Paris-Sud XI, Université de

205

BioMed Central Page 1 of 2

  Engineering Websites

Summary: in a BME pro- gram to support advanced-year courses in biomechanics (cardiovascular or musculoskeletal to identify arrhythmias, myocardial infraction, arte- rial and ventricular diseases, etc.). A useful feature

Gefen, Amit

206

Plastic Changes of Calcitonin Gene-Related Peptide in Morphine Tolerance: Behavioral

  Mathematics Websites

Summary: in the spinal cord (Yu et al., 1994, 1996a,b). It has been reported that intracerebro- ventricular injection induced by intra- cerebroventricular injection of CGRP (Welch et al., 1988). Although, at the spinal

Stephens, Matthew

207

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

  MIT - DSpace

Summary: Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, ...

Majmudar, Maulik D.

208

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

  MIT - DSpace

Summary: The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate ...

Wang, Xinchen

209

Appl. Phys. B 72, 859863 (2001) / Digital Object Identifier (DOI) 10.1007/s003400100562 Applied Physics B

  Engineering Websites

Summary: of helicobacter pylori, which causes ventricular ulcers [5]). De- tection of biomedically-produced NO and its absorption lines can be selected to avoid interference from other species such as CO2 and H2O absorbing


2001-01-01

210

Abstract--A simplified predictor of episodes of paroxysmal atrial fibrillation (PAF) is presented. Over a thirty minute

  Engineering Websites

Summary: -wave detector did not differentiate between regular R-waves and premature ventricular complexes (PVC), it was necessary for us to visually verify whether a particular premature event had a normal R-wave or was a PVC


211

Pathways between sleep disordered breathing and adverse clinical outcomes in heart failure patients : an exploration of proinflammatory effects and depressive symptomatology

  University of California eScholarship Repository

Summary: Heart Failure Etiology Systolic Dysfunction, n (%) DiastolicDiastolic Blood Pressure Are Predictors of Mortality in Systolic Heart Failure.Diastolic Dysfunction, n (%) Left Ventricular Ejection Fraction (%), M (SD) Heart Failure

Jiménez, Jessica Ann
2012-01-01

212

An improved spatial tracking algorithm applied to coronary veins into Cardiac Multi-Slice Computed Tomography volume

  Physics Websites

Summary: of contractile coordination in hearts with severe heart failure, sinus rhythm and ventricular conduction delay using the new Mutli-Slice Computed Tomography (MSCT) capabilities in imaging the heart. Many works

Paris-Sud XI, Université de

213

Fig. 1. Post-processing scheme of radial k-space data for obtaining high resolution fat suppressed and non-fat suppressed data.

  Engineering Websites

Summary: free wall leading to ventricular malfunction and death. Black blood MRI techniques are often used and non-fat suppressed data. (a) (b) Novel Radial MRI Technique for Obtaining High Resolution Black Blood

Bilgin, Ali

214

Intensive Care Med . Author manuscript Impact of acute hypercapnia and augmented positive end-expiratory

  Physics Websites

Summary: Syndrome, Adult ; complications ; metabolism ; physiopathology ; therapy ; Respiratory Rate ; Severity positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome) in patients with severe acute respiratory distress syndrome (ARDS) on right (R) and left ventricular (LV

Paris-Sud XI, Université de

215

Anomalous Coronary Arteries: Anatomic and Functional Assessment by Coronary and Perfusion Cardiovascular Magnetic Resonance in Three Sisters

  CiteSeer

Summary: Combined coronary and perfusion cardiovascular magnetic resonance was performed in three sisters with angina and suspected anomalous coronary arteries. Two sisters had anomalous coronary arteries passing between the aorta and right ventricular outflow tract and had abnormal myocardial perfusion

Nicholas H. Bunce; Shelley L. Rahman; Peter D. Gatehouse; Christine H. Lorenz; Dudley J. Pennell

216

Sudden cardiac death in the young: don’t forget abnormal coronary arteries!

  CiteSeer

Summary: (WBC) count was mildly elevated, and serum creatinine was raised to 150 mmol/L. A bedside transthoracic echocardiogram showed severe hypokinesis and poor thickening of the anterior left ventricular wall, consistent with significant ischaemia/evolving infarction.

Ali Khan; Jim Stewart; Warren Smith
2007-01-01

217

Virtual histology of the human heart using optical coherence tomography

  Engineering Websites

Summary: achieved and validated with Masson Trichrome histology in atrial, ventricular, sinoatrial nodal currently focus on the visualiza- tion of the coronary vasculature--for example, identifying un- stable- tion techniques, including magnetic resonance imaging MRI , computed tomography CT , and ultrasound


218

The development of processing methods for a quantitative histological investigation of rat hearts

  Texas A&M University - TxSpace

Summary: In order to understand the mechanical functions of the cardiac muscle it is important to first understand the microstructure of the tissue. Young et al. (1998) realized that quantitative three-dimensional information about the ventricular...

Jetton, Emily Hope
2004-11-15

219

Development/Plasticity/Repair Dorsally and Ventrally Derived Oligodendrocytes Have

  Biology and Medicine Websites

Summary: from the ventral ventricular zone (VZ) under the influence ofSonicHedgehog,butaminorityaregeneratedfromthedorsalVZinaHedgehog is Sonic Hedgehog (SHH) dependent, but dorsally derived OLPs are SHH independent, possibly relying

Richardson, William D.

220

, 20131189, published 12 March 2014112014J. R. Soc. Interface Dimos Poulikakos and Vartan Kurtcuoglu

  Materials Science Websites

Summary: , Institute of Physiology, 5 Neuroscience Center Zurich, and 6 Zurich Center for Integrative Human Physiology are simulated in the ventricular space using subject-specific anatomy, wall motion and choroid plexus pulsations

Daraio, Chiara

221

A method for guiding ablation catheters to arrhythmogenic sites using body surface electrocardiographic signals

  MIT - DSpace

Summary: Treatment of hemodynamically unstable ventricular arrhythmias requires rapid and accurate localization of the reentrant circuit. We have previously described an algorithm that uses the single-equivalent moving dipole model ...

Barley, Maya E.

222

www.afm-journal.de 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim3738

  Materials Science Websites

Summary: myocytes arranged in layered anisotropic bands around the ventricular cavities. Similarly, vascular tone in arteries car- rying blood from the heart arises from the highly elongated and anisotropic architecture

Parker, Kevin Kit

223

www.afm-journal.de 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1

  Materials Science Websites

Summary: myocytes arranged in layered anisotropic bands around the ventricular cavities. Similarly, vascular tone in arteries car- rying blood from the heart arises from the highly elongated and anisotropic architecture

Parker, Kevin Kit

224

Evaluation of the Role of IKACh in Atrial Fibrillation Using a Mouse Knockout Model

  Biology and Medicine Websites

Summary: not be induced in either type of mouse. Sinus node recovery times after carbachol and sinus cycle lengths were the heart rate and the conduction proper- ties of atrial, atrioventricular (AV) nodal and ventricular tissue

Clapham, David E.

225

An apparatus for high throughput muscle cell experimentation

  MIT - DSpace

Summary: The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

Garcia-Webb, Michael G. (Michael Gregory)
2006-01-01

226

EVIDENCE FOR AN UNFOLDED BORDER-COLLISION BIFURCATION IN PACED CARDIAC TISSUE

  Engineering Websites

Summary: the bifurcation type and investigated the mechanisms that drive alternans in paced bullfrog ventricular myocardium implementation of the alternate pacing technique in bullfrog ven- tricular tissue piece (1 cm x 1 cm x 1 cm

Gauthier, Daniel

227

Non stationary model of the heartbeat time series in atrial fibrillation

  Mathematics Websites

Summary: . This adaptability relies on two mechanisms. The first one is the influence of the autonomous nervous system, ventricular rate. In this situation the control of the autonomous nervous system on the RR sequence fades

Cammarota, Camillo

228

Integrin alpha 5 beta 1 is necessary for regulation of radial migration of cortical neurons during mouse brain development

  MIT - DSpace

Summary: During cerebral cortex development, post-mitotic neurons interact with radial glial fibers and the extracellular environment to migrate away from the ventricular region and form a correct laminar structure. Integrin receptors ...

Marchetti, Giovanni

229

Exercise Training Improves Cardiac and Skeletal Muscle Metabolism in Rats with Pulmonary Arterial Hypertension

  Biology and Medicine Websites

Summary: Exercise Training Improves Cardiac and Skeletal Muscle Metabolism in Rats with Pulmonary Arterial promotes right ventricular (RV) and skeletal muscle dysfunction that contributes to reduced exercise tolerance. As seen for other cardiopulmonary diseases, exercise training (ExT) may ameliorate

Zhou, Yaoqi

230

Evidence regarding clinical use of microvolt T-wave alternans

  MIT - DSpace

Summary: Microvolt T-wave alternans (MTWA) testing in many studies has proven to be a highly accurate predictor of ventricular tachyarrhythmic events (VTEs) in patients with risk factors for sudden cardiac death (SCD) ...

Hohnloser, Stefan H.

231

Using weak impulses to suppress traveling waves in excitable media Grigory V. Osipov and James J. Collins

  Biotechnology Websites

Summary: for the onset of ventricular fibrilla- tion in the heart 3 , which is one of the leading causes of death the system's attractor 14 ; and 2 traveling waves in excitable media can be sepa- rated into fast and slow

Collins, James J.

232

Spectral analyses of avian heart value sounds

  Texas A&M University - TxSpace

Summary: Cardiovascular changes which occur in response to cardiac stress affect the heart valve sounds (HVS). We attempted to quantify the effect of pulmonary hypertension and right ventricular (RV) hypertrophy on the frequency spectrum of HVS. A test...

Jeyaseelan, Prithika
1993-01-01

233

An assay for permeability of the zebrafish embryonic neuroepithelium

  MIT - DSpace

Summary: The brain ventricular system is conserved among vertebrates and is composed of a series of interconnected cavities called brain ventricles, which form during the earliest stages of brain development and are maintained ...

Chang, Jessica T.

234

Angiogenic and Inflammatory Markers of Cardiopulmonary Changes in Children and Adolescents with Sickle Cell Disease

  CiteSeer

Summary: Background: Pulmonary hypertension and left ventricular diastolic dysfunction are complications of sickle cell disease. Pulmonary hypertension is associated with hemolysis and hypoxia, but other unidentified factors are likely involved in pathogenesis as well. Design and Methods: Plasma

Xiaomei Niu; Mehdi Nouraie; Andrew Campbell; Sohail Rana; Caterina P. Minniti; Craig Sable; Deepika Darbari; Niti Dham; N. Scott Reading; Josef T. Prchal; Gregory J. Kato; Mark T. Gladwin; Oswaldo L. Castro; Victor R. Gordeuk

235

Real-time 3D Transesophageal Echocardiography ERIC C. PUA,

  Engineering Websites

Summary: and symptoms of con- genital heart disease such as atrial septal defects, intraatrial membranes and ventricular septal defect occluders and mechanical valves. TEE has also been effective for monitoring cardiac

Smith, Stephen

236

Targeted Deletion Reveals Essential and Overlapping Functions of the

  Biology and Medicine Websites

Summary: with lung hypoplasia and a ventricular septal defect. The miR-17$92 cluster is also essential for B cell in vertebrate development, as attested by the early embryonic lethality of mice with defects in the mi

Bedwell, David M.

237

Pre-weaning Sensorial and Motor Development in Mice Transpolygenic for the Critical Region of Trisomy 21

  Biology and Medicine Websites

Summary: (atrioven- tricular septal defect, ventricular septal defect, atrial septal defect or ductus arterosius-folds, a flat nasal bridge, the mouth permanently open and the tongue protruding. The incidence of heart defects

Smith, Desmond J.

238

Universittsmedizin Gttingen Publikationen und Hochschulschriften 2009

  Biology and Medicine Websites

Summary: septal defect as a post infarction complication. J CARDIOTHORAC SURG, 4: 3. 10. Coskun KO, Popov AF, Coskun ST, Hinz J, Schmitto JD, Körfer R (2009) Surgical treatment of left ventricular aneurysm. Asian

Gollisch, Tim

239

Explicit temporal models for decision-theoretic planning of clinical management

  Computer Technologies and Information Sciences Websites

Summary: uncertainty. As a case study we have selected the congenital cardiac anomaly of ventricular septal defect disease [32, 30, 28]. A larger number of systems have been built to support the management of #3; Appeared

Utrecht, Universiteit

240

Cystatin-C and mortality in elderly persons with heart failure

  University of California eScholarship Repository

Summary: with heart failure (HF). 279 Cardiovascular Health StudyHeart Failure GFR = Glomerular Filtration Rate CHS = Cardiovascular Healthheart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health


2005-01-01

241

Three-dimensional spiral waves in an excitable reaction system: Initiation and dynamics of scroll rings and scroll ring pairs

  Chemistry Websites

Summary: problematic in systems such as the mammalian heart, which is nontransparent and in its entirety difficult to the heart, where rotating vortex structures are believed to cause cardiac ar- rhythmia and ventricular

Steinbock, Oliver

242

Hemodynamic Responses to Varying Postural Stress

  Computer Technologies and Information Sciences Websites

Summary: system (The IQ System) was used to evaluate cardiac output (CO), stroke volume (SV), ventricular ejection responsible for circulatory homeostasis both on earth at +1G and in OG. These results may also serve


243

Cardiovascular effects of apelin in vivo in man 

  Edinburgh, University of - Research Archive

Summary: Background The apelin system is a novel peptidic pathway widely expressed in the heart and vasculature. In preclinical studies, apelin receptor agonism mediates nitric oxide-dependent vasodilatation, reduces ventricular ...

Japp, Alan Gordon
2013-07-06

244

VOLUME 87, NUMBER 6 P H Y S I C A L R E V I E W L E T T E R S 6 AUGUST 2001 Noise Effects on the Complex Patterns of Abnormal Heartbeats

  Biology and Medicine Websites

Summary: sinus heartbeats, S-beats, arise from activity in the si- nus node, the normal pacemaker of the heart the phase fi of the ith ventricular beat in the sinus cycle, i.e., the time interval between the ith ventricular beat and the previous sinus beat normalized by TS [3­6]. Successive values of 4.7 4.9 5.1 5.3 0 50

Glass, Leon

245

Acute Beneficial Hemodynamic Effects of a Novel 3D- Echocardiographic Optimization Protocol in Cardiac Resynchronization Therapy

  CiteSeer

Summary: Background: Post-implantation therapies to optimize cardiac resynchronization therapy (CRT) focus on adjustments of the atrio-ventricular (AV) delay and ventricular-to-ventricular (VV) interval. However, there is little consensus on how to achieve best resynchronization with these parameters. The aim of this study was to examine a novel combination of doppler echocardiography (DE) and three-dimensional echocardiography (3DE) for individualized optimization of device based AV delays and VV intervals compared to empiric programming. Methods: 25 recipients of CRT (male: 56%, mean age: 67 years) were included in this study. Ejection fraction (EF), the primary outcome parameter, and left ventricular (LV) dimensions were evaluated by 3DE before CRT (baseline), after AV delay optimization while pacing the ventricles simultaneously (empiric VV interval programming) and after individualized VV interval optimization. For AV delay optimization aortic velocity time integral (AoVTI) was examined in eight different AV delays, and the AV delay with the highest AoVTI was programmed. For individualized VV interval optimization 3DE fullvolume datasets of the left ventricle were obtained and analyzed to derive a systolic dyssynchrony index (SDI), calculated from the dispersion of time to minimal regional volume for all 16 LV segments. Consecutively, SDI was evaluated in six different VV intervals (including LV or right ventricular preactivation), and the VV interval with the lowest SDI was programmed (individualized optimization).

Carolin Sonne; Lorenz Bott-flügel; Simon Hauck; Hasema Lesevic; Petra Barthel; Fabian Michalk; Jörg Hausleiter; Albert Schömig; Christof Kolb

246

Localization of cardiac L-type Ca2 to a caveolar macromolecular signaling complex

  Biology and Medicine Websites

Summary: (Cav1.2). Immunogold electron microscopy revealed that these proteins colocalize in caveolae. Immunoprecipitation from ventricular myo- cytes using anti-Cav1.2 or anti-caveolin-3 followed by Western blot analysis showed that caveolin-3, Cav1.2, 2-AR (not 1-AR), G protein s, adenylyl cyclase, protein kinase A

Kamp, Tim

247

RESEARCH Open Access Consistency of aortic distensibility and pulse

  Physics Websites

Summary: Herment1 Abstract Background: Arterial stiffness is considered as an independent predictor afterload, which can cause left ventricular hypertrophy [3]. Arterial stiffness is recognized as a major and pulse wave velocity (PWV) are com- monly used to characterize the arterial stiffness [12

Paris-Sud XI, Université de

248

Changes in Large Pulmonary Arterial Viscoelasticity in Chronic Pulmonary Hypertension

  Materials Science Websites

Summary: Changes in Large Pulmonary Arterial Viscoelasticity in Chronic Pulmonary Hypertension Zhijie Wang1, Wisconsin, United States of America Abstract Conduit pulmonary artery (PA) stiffening is characteristic of pulmonary arterial hypertension (PAH) and is an excellent predictor of mortality due to right ventricular

Lakes, Roderic

249

Evaluation of aortic compliance in humans HELMUT F. KUECHERER,1 ARMIN JUST,2 AND HARTMUT KIRCHHEIM2

  Biology and Medicine Websites

Summary: and conducts pulsatile ventricular output (7) and contributes mostly to total compliance of the arterial tree properties assumes that the arterial tree is an elastic chamber (windkessel) in which the diastolic pressure decays exponentially with a time constant that is determined by total arterial resistance and compliance

Just, Armin

250

Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells

  Physics Websites

Summary: . Neither bFGF nor NT3 influences the proportion of glia or neurons in short to medium term cultures; bFGF; NT3; corticogenesis INTRODUCTION Cortical stem cells from the ventricular zone are responsible, Ecole Normale Supérieure de Lyon, 69364 Lyon, France ABSTRACT Basic fibroblast growth factor (bFGF

Paris-Sud XI, Université de

251

Refinement of the HCUP Quality Indicators: Appendix 6 Indicator Definitions

  University of California eScholarship Repository

Summary: closures of atrial septal defects (procedure codes 35.51-or ventricular septal defects (codes 35.53, 35.72) or atrialSEPTAL DEFECT PROSTH REP HRT SEPTA NOS PROS REP ENDOCAR CUSHION GRFT REPAIR HRT SEPT NOS GRAFT REPAIR ATRIAL

Davies, Sheryl M.; Geppert, Jeffrey; McClellan, Mark; McDonald, Kathryn M.; Romano, Patrick S.; Shojania, Kaveh G.
2001-01-01

252

Neuron, Vol. 23, 473485, July, 1999, Copyright 1999 by Cell Press Cellular and Molecular Guidance of GABAergic

  Biology and Medicine Websites

Summary: and subventricularSummary zones of the LGE (Anderson et al., 1997), indicates a striatal origin for the majority in the striatal-migration and found that the ventricular zone (VZ) of neocortical pathway (reviewed in Lumsden of endogenous Slit signaling inhibits the Here, we have used an in vitro explant assay to studyrepulsive

Wu, Jane Y.

253

Efficient Modeling of Excitable Cells Using Hybrid Automata

  Computer Technologies and Information Sciences Websites

Summary: with continuous dynamics. Our goal is to efficiently capture the behavior of excitable cells previously modeled-Huxley model of the giant squid axon, the Luo-Rudy dynamic model of a guinea pig ventricular cell, and a model). To model electrical wave propagation in a cell network, the single-cell HA models are linked to a classical

Smolka, Scott

254

Efficient Modeling of Excitable Cells Using Hybrid Automata

  Computer Technologies and Information Sciences Websites

Summary: ), which combine discrete transition graphs with continuous dynamical sys- tems, to modeling complex-Huxley model of the giant squid axon, the Luo-Rudy dynamic model of a guinea pig ventricular cell, and a model to pacing rates). To model electrical wave propagation in a cell network, the single-cell HA models

Grosu, Radu

255

Progress in Biophysics and Molecular Biology, 69(2-3):333351, 1998. 1 Physical and Geometrical Modeling for

  Biology and Medicine Websites

Summary: being to use real data to guide recovery when possible, but use the model as a smart interpolator Modeling for Image-Based Recovery of Left Ventricular Deformation James Duncan, Ph.D., , Pengcheng Shi, Ph or otherwise corrupted image data. Often models are employed to help guide this recovery process, with the goal

Duncan, James S.

256

The chair`s vision The chair of Product Development

  Materials Science Websites

Summary: - interested in control systems development and system modeling - familiar with Matlab/Simulink environmentsThe chair`s vision The chair of Product Development and Engineering Design at the ETH Zurich/Master Thesis Development of a fluid viscosity control system Project Ventricular Assist Devices (VADs

Daraio, Chiara

257

Molecular Ecology Notes (2004) 4, 626628 doi: 10.1111/j.1471-8286.2004.00716.x 2004 Blackwell Publishing Ltd

  Biology and Medicine Websites

Summary: and venous dilatation and decrease renal sodium reabsorption as a response to left ventricular wall tension to parallel an increase in blood pressure.8 Either by boosting the sympathetic activity, increasing sodium of gender, only women were selected. The patients with a history of chronic cardiac, renal, pulmonary

Steinfartz, Sebastian
2004-01-01

258

Control of myocyte remodeling in vitro with engineered substrates

  Materials Science Websites

Summary: microenvironments can regulate cell be- havior by imposing physical restrictions on their geometry and size are concurrent with changes in the size, shape, and cytoskeleton of ventricular myocytes. In this study, we asked how myocytes adapt their size, shape, and intracel- lular architecture when spatially confined

Parker, Kevin Kit

259

Cardiovascular Research 1983;17:243-250 Effects of low [K+

  Physics Websites

Summary: ; tetrodotoxin; arrhythmia. SUMMARY Ventricular and Purkinje action potentials were recorded oscillations of potential appeared at rest. In Purkinje cells, increasing concentrations of tetrodotoxin from tetrodotoxin and local anaesthetics) also depress the steady-state ("window") sodium current 10 11 and shorten

Paris-Sud XI, Université de

260

Zrich, 30. September 2006 PROMOTIONSLISTE

  Environmental Sciences and Ecology Websites

Summary: ,,Effect of Aging on Expression of Sex Steroid Receptors in the Male Cardiovascular System" Celeiro" Cominelli Silvano Giovanni, von/in Zürich ,,Impact of Associated Coronary Artery Disease on Left Ventricular criteria for differentiation of Fabry disease from amyloid heart disease and other causes of left

Zürich, Universität

261

Characterisation of Patterned Irregularity in Locally Interacting,

  Mathematics Websites

Summary: imaging of electrical activity in isolated heart tissue and computa- tional models of ventricular #12- plicated dynamics of the re-entrant waves of excitation in the tissue, but also the way the appearance of heart tissue. One way of indirect comparison is to compare characteristics of the complexity

Biktashev, Vadim N.

262

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation

  Chemistry Websites

Summary: a rapid strategy that allows localized in vivo transfection of plasmid DNA within the adult neurogenic niches without detectable brain damage. Injection of plasmid DNA into the ventricular system or directly electroporation provides a new approach to study the adult brain. The development of transgenic animal technology1

Cai, Long

263

Ion Channel Basis for Alternans and Memory in Cardiac Myocytes MINGYI LI and NIELS F. OTANI

  Engineering Websites

Summary: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH (Received 3 February phasings of the x1 and f gate perturbations associated with the slow outward and slow inward currents death caused by ventricular fibrillation accounts for 300,000 to 400,000 deaths annually in the United

Otani, Niels F.

264

Chronaxie of Defibrillation: A Pathway Toward Further Optimization of Defibrillation Waveform?

  Engineering Websites

Summary: R. Efimov, Ph.D. From the Department of Biomedical Engineering, Washington University, St. Louis effective therapy against sudden cardiac death. However, despite major improvements over the last several, which has slowed further improvement of the therapy. In 1899, while studying induction of ventricular


265

The role of M cells and the long QT syndrome in cardiac arrhythmias: simulation studies of reentrant excitations using a

  Materials Science Websites

Summary: Department of Physics Center for Theoretical Biological Physics, University of California, San Diego. La then study whether M cell domains, with their slow repolarization, can function as wave blocks for premature to ventricular #12;brillation, the leading cause of sudden death in the industrialized world. In this numerical

Henry, Hervé

266

Analysis of Cardiac Motion with Recursive Comb Filtering John C. McEachen II y , Arye Nehorai y , and James S. Duncan y;z

  Biology and Medicine Websites

Summary: Analysis of Cardiac Motion with Recursive Comb Filtering John C. McEachen II y , Arye Nehorai y Yale University New Haven, CT 06520­8042 ABSTRACT A framework for temporal analysis of left ventricular into consideration this relationship as well as knowledge of temporal trends. Experimental results for contours

Duncan, James S.

267

d Original Contribution ELECTROMECHANICAL WAVE IMAGING OF BIOLOGICALLY AND

  Biology and Medicine Websites

Summary: with electronic and biologic pacemakers (EPM and BPM respectively). After atrioventricular node ablation, dogs received a BPM at the left ventricular (LV) epicardial base (n 5 2). EWI was performed trans thoracically during NSR, BPM and EPM pacing, in conscious dogs, using an unfocused transmit sequence at 2000 frames

Konofagou, Elisa E.

268

Within-Patient Correlation Influence on Defibrillation Outcome Prediction using a Gaussian Mixture Model

  Computer Technologies and Information Sciences Websites

Summary: for the development of an outcome predictor model to discriminate "Success" versus "No success". Vector of predictors -v are extracted from time and non-linear dynamics domains and a Gaus- sian Mixture Model). At 5 s post-shock, an Organized Rhythm (OR) is considered as "Success" and Ventricular Fibrillation (VF

Boyer, Edmond

269

Cortical Target Depletion and the Developing Lateral Geniculate Nucleus

  Biology and Medicine Websites

Summary: , we depleted variable proportions of the principal targets of geniculocortical axons, layer IV neurons these neurons were being generated in the ventricular zone. We demonstrate that after more than 75% loss of layer IV there is no reduction in cell number in the LGd. HRP (horseradish peroxidase) injections

Finlay, Barbara L.

270

Real-Time Color-Flow Magnetic ResonanceImaging of Congenital Heart Disease E. De La Pena-Almaguer, K. S. Nayak, M. Terashima, P.C. Yang,

  Biology and Medicine Websites

Summary: -holding and cardiac gating. We developed a real-time color-flow MRI system, which provides color- coded blood flow in atrial and ventricular septal defects as well as extra-cardiac flow abnormalities. This is a promising tool for the rapid assessment of CHD. Background: A comprehensive cardiac MRI exam should rapidly

Southern California, University of

271

08853010/$25.00 2009 IEEE 2320 IEEE TransacTIons on UlTrasonIcs, FErroElEcTrIcs, and FrEqUEncy conTrol, vol. 56, no. 10, ocTobEr 2009

  Engineering Websites

Summary: as to characterize the cardiac function. Based on a 3-D finite-element (FE) canine left-ventricular model the enormous death toll. doppler myocardial imaging [1] and strain rate imag- ing [2] use doppler, doppler-based methods are angle-dependent be- cause typically only the information along the axial direc

Konofagou, Elisa E.

272

J. Phys. III France 4 (1994) 1121-1127 JUNE 1994, PAGE 1121 Classification

  Computer Technologies and Information Sciences Websites

Summary: .45 Trends in cardiac dynamics : towards coupled models of intracavity fluid dynamics and deformable wall in cardiac mechanics which takes into account the coupled effects of ventricular mechanics and intracardiac applied to the internal wall surface at every instant of the cardiac cycle, to calculate the overall

Boyer, Edmond
1994-01-01

273

Artif Intell Med. Author manuscript Model-based analysis of myocardial strain data acquired by tissue Doppler

  Computer Technologies and Information Sciences Websites

Summary: acquired by tissue Doppler imaging Le Rolle Virginie 1 * , Hernandez Alfredo I. 1 , Richard Pierre-Yves 2 Objective Tissue Doppler Imaging (TDI) is commonly used to evaluate regional ventricular contraction of the left ventricle, which takes into account cardiac electrical, mechanical and hydraulic activities

Boyer, Edmond

274

Brain Mapping as a Tool to Study Neurodegeneration Liana G. Apostolova and Paul M. Thompson

  Biology and Medicine Websites

Summary: cognitively impaired, in partic- ular, are at a fivefold increased risk of imminent conversion to dementia, and automated methods for map- ping ventricular anatomy. Applications to AD and other dementias are discussed, dementia, mild cognitive impairment, Alzheimer's disease, schizophrenia, de- pression, human brain

Thompson, Paul

275

Neuronal Production, Migration, and Differentiation in a Vocal Control Nucleus of the Adult Female Canary Brain

  Engineering Websites

Summary: ventricular zone that incorporate tritiated thymidine during the S phase pre- ceding their mitosis; after treatment. We determined the origin of the thymidine-incorporating neurons by sacrificing two thymi- dineNeuronal Production, Migration, and Differentiation in a Vocal Control Nucleus of the Adult Female


276

Large-scale cortical displacement of a human retinotopic map

  Biology and Medicine Websites

Summary: indicates right hemisphere peri-ventricular heterotopia and dotted arrow indicates the locus of gray a shift of language representation to the right hemisphere [4,5]. In the visual domain, congenitally blind. Similar to control subjects, the upper right visual ¢eld mapped onto ventral left hemisphere

Slotnick, Scott D.

277

CARDIAC ARRHYTHMIA CLASSIFICATION USING SUPPORT VECTOR MACHINES

  Environmental Sciences and Ecology Websites

Summary: CARDIAC ARRHYTHMIA CLASSIFICATION USING SUPPORT VECTOR MACHINES M.G. Tsipouras1,2 , C. Voglis1 , I to simple constraints, which is solved using the BOXCQP method. Four types of cardiac rhythms beats methodology four types of cardiac rhythm beats are classified: (1) ventricular flutter/fibrillation, (2

Lagaris, Isaac

278

Proc. Intl. Soc. Mag. Reson. Med 9 (2001) 1 Automated Segmentation of Cardiac Magnetic Resonance Images

  Mathematics Websites

Summary: Proc. Intl. Soc. Mag. Reson. Med 9 (2001) 1 Automated Segmentation of Cardiac Magnetic Resonance cardiac volumes and function in a non- invasive manner and is generally considered to be the current gold- standard for cardiac imaging [1]. Measurement of ventricular volumes, muscle mass and function is based


2001-01-01

279

Data Fusion of Left Ventricle Electro-Anatomic Mapping and Multislice Computerized Tomography for Cardiac Resynchronisation Therapy

  Physics Websites

Summary: for Cardiac Resynchronisation Therapy Optimization F Tavard1,2 , A Simon1,2 , C Leclercq1,2,3 , P Mabo1, France Abstract Cardiac Resynchronization Therapy is a treatment for bi-ventricular asynchronism. It can. EAM data provide an approximation of the left ventri- cle (LV) 3D-surface (SEAM ). Left cardiac

Paris-Sud XI, Université de

280

60 80 100 120 140 160 180 Automated Segmentation of Cardiac Magnetic Resonance Images

  Mathematics Websites

Summary: 55 56 57 58 59 60 61 62 63 64 65 66 Automated Segmentation of Cardiac Magnetic Resonance Images M. B cardiac volumes and function in a non-invasive manner, and is generally considered the current gold standard for cardiac imaging [1]. However, assessments require manual tracings of the left- ventricular


281

Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against tachyarrhythmias

  Engineering Websites

Summary: Hibernator Citellus undulatus maintains safe cardiac conduction and is protected against of Sciences, Puschino, Russia. BACKGROUND Most mammals experience cardiac arrest during hypothermia reserved. doi:10.1016/j.hrthm.2005.06.012 #12;succumbs to cardiac arrest due to atrial and ventricular


282

Appendix A -Binomial Kernel and Difference of Gaussians Operator 1 1 1 1 2 1 1 3 3 1 1 4 6 4 1

  Engineering Websites

Summary: description using weighted symmetric axis features." Pattern Recognition 10: 167-180. Bohs, L., B. Friemel, et of absolute left ventricular volume by radionuclide angiography: A technical review." Nuclear Medicine ultrasound." Ultrasound in Medicine and Biology 19(9): 751- 761. Brady, M. (1983). Criteria

Stetten, George

283

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders.

  Physics Websites

Summary: be eliminated during volume traversal, thus improving the visual perception of the endocardial wall. Keywords: 3 scheme for 3-D navigation into the heart cavities for pre- operative planning using multislice X in hearts with severe heart failure (HF), sinus rhythm and ventricular conduction delay [11]. In 1998

Paris-Sud XI, Université de

284

AUTOMATIC GENERATION OF NOISE-FREE TIME-ACTIVITY CURVE WITH GATED BLOOD-POOL

  Physics Websites

Summary: AUTOMATIC GENERATION OF NOISE-FREE TIME-ACTIVITY CURVE WITH GATED BLOOD-POOL EMISSION TOMOGRAPHY-dimensional method for the generation of right and left ventricular time-activity curves (TAC) was described is based on the use of a priori knowl- edge on the shape of a time activity curve. This method was compared

Paris-Sud XI, Université de

285

Riesgo Elctrico Bajo Control

  Computer Technologies and Information Sciences Websites

Summary: del cuerpo humano. · Quemaduras por choque o arco eléctrico. · Caídas o golpes como consecuencia de corriente eléctrica a través del cuerpo puede provocar distintas lesiones que van desde las quemaduras hasta la fibrilación ventricular y la muerte. Efectos de la electricidad sobre el organismo humano Cuando

Cardeñosa, Jesús

286

Multifunctional Interventional Devices for MRI: A Combined Electrophysiology/MRI Catheter

  Biology and Medicine Websites

Summary: tachycardias, AV-nodal reentrant tachycardias, ac- cessory pathways, atrial flutter, and idiopathic ventricular for arrhythmias such as atrial flutter and fibrillation. Second, cardiac motion and flow dynamics can be monitored that require continuous lines of ablation, such as treatment for atrial flutter, atrial fibrillation

Atalar, Ergin

287

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

  Condensed Matter (arXiv)

Summary: We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

A. S. Moskvin; A. M. Ryvkin; O. E. Solovyova; V. S. Markhasin
2011-03-31

288

Subject: Web of Science From: noreply@isiknowledge.com

  Biology and Medicine Websites

Summary: (s): GRAY, RA; JALIFE, J; PANFILOV, AV; et al. Title: MECHANISMS OF CARDIAC FIBRILLATION Source: SCIENCE.57 4. Author(s): Panfilov, AV Title: Spiral breakup as a model of ventricular fibrillation Source: 0375-9601 3 5 2 5 2 80 4.44 7. Author(s): PERTSOV, AM; ERMAKOVA, EA; PANFILOV, AV Title: ROTATING

Utrecht, Universiteit

289

A description of the paraventricular and supraoptic nuclei of the bovine hypothalamus

  Texas A&M University - TxSpace

Summary: the nedial border of the supraoptic ~leuc, 15 h snsLL ness of epproafcrately forty cello, forafng aa accessory par?ventricular csccLeus, fs located equidistantly betveea the vsatral border of Che paravsaCrieular nucleus and the as4fsl border ?f ths...

Talukdar, Amir Hussain
1960-01-01

290

Introduction: Self-organization in nonequilibrium chemical systems Irving R. Epstein

  Chemistry Websites

Summary: , understand- ing ventricular fibrillation Chaos 8 1 , 1998 , nonlinear sci- ence in chemical engineering Chaos systems than are physicists or engineers. This is probably the result of two factors. First, chemists homogeneous isothermal chemical oscillator to be described was the reaction of iodate, iodine, and hydrogen

Steinbock, Oliver

291

Clinical Features, Molecular Genetics, and Inheritance: Dilated cardiomyopathy (DCM) is a severe disease of heart muscle characterized by progressive

  Biology and Medicine Websites

Summary: function and is a major cause of congestive heart failure. The prevalence of DCM is estimated at 1 in 2) is a severe disease of heart muscle characterized by progressive ventricular dilation and impaired systolic Foundation The American Heart Association Phone: 978-535-2594 Phone: 1-800-242-8721 Fax: 978-535-5849 www

Das, Soma

292

www.ipej.org 104 Review Article

  CiteSeer

Summary: Sustained chronic tachyarrhythmias often cause a deterioration of cardiac function known as tachycardia-induced cardiomyopathy or tachycardiomyopathy. 1 It has been recognized that the tachycardiomyopathy occurs in experimental models 2 and also in patients with supraventricular or ventricular tachycarrhythmias. 3-6 Generally, cardiac function will recover if

Yuji Nakazato

293

Clinical Features, Molecular Genetics, and Inheritance: Dilated cardiomyopathy (DCM) is a severe disease of heart muscle characterized by progressive

  Biology and Medicine Websites

Summary: function and is a major cause of congestive heart failure. The prevalence of DCM is estimated at 1 in 2) is a severe disease of heart muscle characterized by progressive ventricular dilation and impaired systolic Resources: The Progeria Research Foundation The American Heart Association Phone: 978-535-2594 Phone: 1

Das, Soma

294

Original Research Single-Breathhold, Four-Dimensional, Quantitative

  Engineering Websites

Summary: Function Using Triggered, Real-Time, Steady-State Free Precession MRI in Heart Failure Patients Girish (LV) and right ventricular (RV) function in heart failure patients. Materials and Methods: A total of 20 heart failure patients (mean age 59 17 years) underwent scanning with our new, real-time, spiral

Southern California, University of

295

ISSN: 1524-4539 Copyright 2007 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online

  Biology and Medicine Websites

Summary: ;116:2580-2586.) Key Words: diastole echocardiography heart failure mechanics myocardium Left ventricular (LV) fillingISSN: 1524-4539 Copyright © 2007 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272 Greenville Avenue, Dallas

Duncan, James S.

296

Differences in Na and Ca spikes as examined by application of tetrodotoxin, procaine, and manganese

  CiteSeer

Summary: and procaine but the plateau phase of the action potential is little affected. In contrast the suppressing effect of manganese ions is mainly on the plateau phase. The results suggest that the plateau phase of the ventricular action potential is related to the conductance increase in the membrane to

Susumu Hagiwara; Shigehiro Nakajima
1966-01-01

297

Quantification of Phase Recurrences in Atrioventricular (AV) Conduction during Atrial Arrhythmias

  Biology and Medicine Websites

Summary: Masè1 , L Glass2 , F Ravelli1,3 1 Dept of Physics, University of Trento, Trento, Italy 2 Dept) is one of the principal strategies in the therapy of these arrhythmias. Nevertheless the mechanisms in cardiology documenting the statistical properties of ventricular activity during AF [1]. In addition more

Glass, Leon

298

CCaarrddiioovvaassccuullaarr RReesseeaarrcchh PPrrooppoossaall OOppppoorrttuunniittiieess JJuullyy 22001111

  Biology and Medicine Websites

Summary: Opportunity Announcement (FOA) issued by the National Heart, Lung, and Blood Institute and National Institute01) The purpose of this FOA is to encourage innovative molecular and physiological research-Right Ventricular Axis Research Program (R01) This funding opportunity announcement (FOA) solicits research grant

Thomas, David D.

299

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

  CERN Preprints

Summary: We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

Moskvin, A S; Solovyova, O E; Markhasin, V S
2011-01-01

300

Dissipation of the excitation front as a mechanism of self-terminating arrhythmias

  Mathematics Websites

Summary: cause arrhythmia as well as lead to its self-termination. We use Courtemanche et al. model of human, as the inhomogeneity creates conditions for simultaneous dissipation of their excitation fronts. Key words: human Introduction. Most modern theories of ventricular and atrial #12;brillation (Pan#12;lov & Pertsov 2001, Jalife

Biktashev, Vadim N.

301

RESEARCH Open Access Impact of routine percutaneous coronary

  Physics Websites

Summary: -of-hospital cardiac arrest due to ventricular fibrillation Pierrick Cronier1,2* , Philippe Vignon3 , Koceila hypothermia (MTH) to treat patients arrest (OHCA) related is responsible for more than 50% of out-of-hospital cardiac arrest (OHCA) cases [1]. In this setting, coronary

Paris-Sud XI, Université de

302

SAFETY SLIDES Electrospraying/Electrospinning equipment in 66-353

  Materials Science Websites

Summary: of the shock may range from a slight tingle to severe burns to cardiac arrest. 6 Current Reaction 1 Milliampere; "let-go" range 50-150 Milliamperes Extreme pain, respiratory arrest, severe muscular contraction 1000-4,300 Milliamperes Ventricular fibrillation 10,000+ Milliamperes Cardiac arrest, severe burns and probable death

Cohen, Robert E.

303

JOURNAL OF EXPERIMENTAL ZOOLOGY 290:751758 (2001) 2001 WILEY-LISS, INC.

  Environmental Sciences and Ecology Websites

Summary: Expression in the Red, White, and Ventricular Muscle of Juvenile Stages of Rainbow Trout FRANCES E. WEAVER, show differences in red muscle contractile properties: parr red muscle has faster kinetics and a faster maximum shortening velocity than smolt red muscle. A developmental reduction in the number of MHC isoforms

Coughlin, David J.

304

MATHEMATICAL BIOSCIENCES 10.3934/mbe.20xx.xx.xx AND ENGINEERING

  Mathematics Websites

Summary: . 1­xx A MATHEMATICAL MODEL OF THE PURKINJE-MUSCLE JUNCTIONS Abstract. This paper is devoted to the construction of a mathematical model of the His-Purkinje tree and the Purkinje-Muscle Junctions (PMJ). A simple network is isolated from the muscle except at its endpoints that are connected to the ventricular wall

Coudière, Yves

305

A New Class of Antiarrhythmic-Defibrillatory Agents Ofra Levy,a

  Biotechnology Websites

Summary: either coronary heart disease2,3 or con- gested heart failure.4 It is commonly accepted that ven approach. It has been commonly accepted that the ability of the mammalian heart to defibrillate spontaneously is related to its ventricular muscle mass.10 Accordingly, small hearts defibrillate spontaneously

Keinan, Ehud

306

CARDIOTHORACIC ANESTHESIOLOGY: The Annals of Thoracic Surgery CME Program is located online at http://cme.ctsnetjournals.org.

  Computer Technologies and Information Sciences Websites

Summary: of ventricular assist devices (VADs) for treat- ment of end-stage heart failure has steadily in- creased during University, Pittsburgh; and Artificial Heart Program, University of Pittsburgh Medical Center, Pittsburgh of the Artificial Heart Program at the University of Pittsburgh Medical Center. This was supplemented

Druzdzel, Marek J.

307

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research

  Biology and Medicine Websites

Summary: ventricular endocardial boundaries from RF ultra- sound. Our method incorporates a computationally efficient is achieved jointly using an independent identically distributed (i.i.d.) spatial model for RF intensity and a multiframe conditional model that relates neigh- boring frames in the image sequence. Segmentation using

Duncan, James S.

308

Shape versus size: Improved understanding of the morphology of brain structures

  CiteSeer

Summary: schemes, a finescale, global surface characterization using spherical harmonics, and a coarsely sampled medial representation (3D skeleton). Driving applications are the detection of group differences of amhygdala-hippocampal shapes in schizophrenia and the analysis of ventricular shape similarity in a

Guido Gerig; Martin Styner; Martha E. Shenton; Jeffrey A. Lieberman
2001-01-01

309

Shape analysis of brain ventricles using SPHARM

  CiteSeer

Summary: Enlarged ventricular size and/or asymmetry have been found markers for psychiatric illness, including schizophrenia. However, this morphometric feature is non-specific and occurs in many other brain diseases, and its variability in healthy controls is not sufficiently understood. We studied

G. Gerig; M. Styner; D. Jones; D. Weinberger; J. Lieberman
2001-01-01

310

Components on the Electrocardiogram Cellular Basis and Clinical Significance

  CiteSeer

Summary: Ventricular repolarization components on the surface electrocardiogram (ECG) include J (Osborn) waves, ST-segments, and T- and U-waves, which dynamically change in morphology under various pathophysiologic conditions and play an important role in the development of ventricular arrhythmias. Our primary objective in this review is to identify the ionic and cellular basis for ventricular repolarization components on the body surface ECG under normal and pathologic conditions, including a discussion of their clinical significance. A specific attempt to combine typical clinical ECG tracings with transmembrane electrical recordings is made to illustrate their logical linkage. A transmural voltage gradient during initial ventricular repolarization, which results from the presence of a prominent transient outward K ? current (I to)-mediated action potential (AP) notch in the epicardium, but not endocardium, manifests as a J-wave on the ECG. The J-wave is associated with the early repolarization syndrome and Brugada syndrome. ST-segment elevation, as seen in Brugada syndrome and acute myocardial ischemia, cannot be fully explained by using the classic concept of an “injury current ” that flows from injured to uninjured myocardium. Rather, ST-segment elevation may be largely secondary to a loss of the AP dome in the epicardium,

Ventricular Repolarization; Peter R. Kowey

311

Fax +41 61 306 12 34 E-Mail karger@karger.ch

  Biology and Medicine Websites

Summary: ;73:26­42 DOI: 10.1159/000202988 Pyloric Neuron Morphology in the Stomatogastric Ganglion of the Lobster microscopy Crustacea Alexa dyes Stomatogastric Panulirus Morphology Lobster Abstract The pyloric network stomatogastric ganglion stn stomatogastric nerve VD ventricular dilator (neuron) #12;Lobster (Panulirus) Pyloric

Hooper, Scott

312

EE 210: CIRCUITS AND DEVICES INTRODUCTION TO THE GENERAL ELECTRONICS

  Engineering Websites

Summary: muscular contractions. Individual cannot let go. Death is possible. 1000-4300 mA Ventricular fibrillation (the rhythmic pumping action of the heart ceases.) Muscular contraction and nerve damage occur. Death is most likely. 10,000 mA Cardiac arrest, severe burns and probable death. Wet conditions are common

Lozano-Nieto, Albert

313

ELECTRICAL ENGINEERING TECHNOLOGY PROGRAM EET 105: ELECTRICAL SYSTEMS

  Engineering Websites

Summary: .osha.gov/SLTC/etools/construction/electrical_incidents/mainpage.html Cardiac arrest, severe burns and probable death.10,000 mA Ventricular fibrillation (the rhythmic pumping action of the heart ceases.) Muscular contraction and nerve damage occur. Death is most likely. 1000-4300 mA Extreme pain, respiratory arrest, severe muscular contractions. Individual cannot let go. Death

Lozano-Nieto, Albert

314

Steven W. Day1 e-mail: sday@alumni.virginia.edu

  Engineering Websites

Summary: Steven W. Day1 e-mail: sday@alumni.virginia.edu James C. McDaniel The University of Virginia activation of the clotting cascade due to regions of elevated shear stress adjacent to separated or stagnant flow. DOI: 10.1115/1.1865189 Introduction A left ventricular assist device LVAD can effectively relieve

Day, Steven

315

Apical Ballooning Syndrome: A Complication of Dual Chamber Pacemaker Implantation

  CiteSeer

Summary: mglikson/at/post.tau.ac.il Apical ballooning is a cardiac syndrome (Takotsubo Cardiomyopathy) described as a typical form of acute transient left ventricular dysfunction. While its onset has often been associated with emotionally or physically stressful situations, it has an overall favorable prognosis. We describe here a case of transient apical ballooning following permanent pacemaker implantation.

unknown authors

316

Hyperbolic Ricci Flow and Its Application in Studying Lateral Ventricle Morphometry

  Mathematics Websites

Summary: Hyperbolic Ricci Flow and Its Application in Studying Lateral Ventricle Morphometry Jie Shi1 , Paul@loni.ucla.edu Abstract. Here we propose a novel method to compute surface hy- perbolic parameterization for studying be computed by geodesic lengths under hyperbolic metric. For lateral ventricular sur- face registration, we

Wang, Yalin

317

Three-dimensional mapping of the lateral ventricles in autism Christine N. Vidala

  Biology and Medicine Websites

Summary: resonance imaging (MRI) studies of lateral ventricular anatomy in autism have yielded inconsistent results. Several studies have reported an increase in lateral ventricle volume (Piven et al., 1995; Howard et al in the total volume of the lateral ventricles between patients and controls. Among those studies which

Thompson, Paul

318

Orcokinin Peptides in Developing and Adult Crustacean Stomatogastric

  Biology and Medicine Websites

Summary: in the inferior ventricular nerve. Matrix-assisted laser desorption/ionization mass spectrometry mass profiling fam- ily reveal cells and fibers that stain in the sixth abdominal ganglion of O. limosus and fibers-assisted laser desorption/ ionization (MALDI) time-of-flight mass spectrometry (TOF MS) to describe the presence

Thirumalai, Vatsala

319

Surface Multivariate Tensor-based Morphometry on Premature Neonates: A Pilot Study

  Mathematics Websites

Summary: anatomy of subcortical structures between healthy preterm and term-born neonates. We first reconstruct become possible to detect and track how neurological disorders affects brain anatomy, and in particular the anatomy of subcortical structures. For example, hippocampal and #12;ventricular surface morphology have

Wang, Yalin

320

Toward Real-time Simulation of Cardiac Dynamics Ezio Bartocci

  Computer Technologies and Information Sciences Websites

Summary: disorders, including spiral waves and spiral wave breakup. The achievement of real-time applications without or bradycardia, see Fig. 1(a)) or the appearance of multiple frequencies (polymorphic ventricular tachycardia or part of this work for personal or classroom use is granted without fee provided that copies

Grosu, Radu

321

PROOF COPY 007704JBO Three-dimensional panoramic imaging of cardiac

  Computer Technologies and Information Sciences Websites

Summary: arrhythmias in rabbit heart Fujian Qu Crystal M. Ripplinger Vladimir P. Nikolski Washington University ventricular arrhythmias and the termination of arrhyth- mias by strong electric shocks. Panoramic imaging hearts n=18 during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal

Grimm, Cindy

322

DownloadedBy:[UniversiteitMaastricht]At:13:0216May2007 FULL LENGTH RESEARCH ARTICLE

  Biology and Medicine Websites

Summary: exacerbate into lethal arrhythmias. Hibernating species are protected against these arrhythmias by a non threatening arrhythmias (Kle´ber and Rudy 2004). Cooling hearts of rabbits or humans eventually causes conduction block or ventricular arrhythmias (Johansson 1996; Fedorov et al. 2005). The heart

Barnes, Brian McRae

323

Measuring the acoustoelectric interaction constant using ultrasound current source density This article has been downloaded from IOPscience. Please scroll down to see the full text article.

  Biology and Medicine Websites

Summary: associated with arrhythmias. (Some figures may appear in colour only in the online journal) 1. Introduction Cardiac catheter ablation has evolved to be a standard clinical treatment for arrhythmia. The procedure, consequently, not able to detect non-sustained arrhythmias (e.g., ventricular tachycardia) (Duru 2002, Markides

Witte, Russell S.

324

V. Cortical Development and Neural Disorder Fates and functions of NG2 cells in the postnatal CNS

  Biology and Medicine Websites

Summary: : Oligodendrocyte precursors (OLPs, also known as NG2 cells) are generated in the ventricular zones (VZ be induced to generate neurons as well as oligodendrocytes and astrocytes in culture, the idea developed overwhelmingly generate new myelinating oligodendrocytes during adulthood. Early reports that NG2 cells might

Kazama, Hokto

325

WILLIAM DAVID RICHARDSON PhD FLS FMedSci May 2010 August, 1951 in Belfast, Northern Ireland (UK citizen).

  Biology and Medicine Websites

Summary: .T., Richardson, W.D., and Raff, M.C. (1992). Cell death and control of cell survival in the oligodendrocyte expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage expression of myelin genes: evidence for a focal source of oligodendrocyte precursors in the ventricular zone

Richardson, William D.

326

1450 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 58, NO. 5, MAY 2011 Dynamic Brain Phantom for Intracranial

  Biology and Medicine Websites

Summary: of the ventricles are obtained from a normal subject and (right) patient with obstructive hydrocephalus with the MR--Knowledge of intracranial ventricular volume is im- portant for the treatment of hydrocephalus, a disease in which cere- brospinal fluid (CSF) accumulates in the brain. Current monitor- ing options involve MRI or pressure

Linninger, Andreas A.

327

July 2010 Volume 6, Number 1 www.thejns.org

  Engineering Websites

Summary: and ventricular volume growth in normal compared with hydrocephalic mice. Methods. Hydrocephalus was induced in 14 transmantle pressure gradients. These 2 patterns of hydrocephalus were significantly discriminable using of neuroimaging technology, shunt-valve design, and surgical techniques, outcomes in patients with hydrocephalus


328

Exceptional CO2 Tolerance in White Sturgeon (Acipenser trans-montanus) Is Associated with Protection of Maximum Cardiac

  Environmental Sciences and Ecology Websites

Summary: heart rate, Qmax, POmax, and rate of ventricular force generation (FO) by 23%, 28%, 26%, and 18 sensitive to hypercapnia and the associated acidosis. The routine heart rate (fH) of rainbow trout to date. We investigated whether this exceptional CO2 tolerance extended to the heart, an organ generally

Farrell, Anthony P.

329

The Effects of Social Environment on Adult Neurogenesis in the Female Prairie Vole

  Biology and Medicine Websites

Summary: - ventricular zone (SVZ) and dentate gyrus of the hip- pocampus (DG) and to be influenced by both exogenous., 1998). In the dentate gyrus (DG) of the hippocampus, cells proliferate in the subgranular zone al., 1996; Gould et al., 1997). In the subventricular zone (SVZ), cells proliferate and then migrate

Hull, Elaine

330

Within 24 h ofadmission, he worsened with a temperature of394°C and respiratory distress (radiography showed right middle-zone

  Biology and Medicine Websites

Summary: cardiomyopathy associated with Borrelia burgdorferi Bergler-Klein and colleagues (Aug 1, p 317) report "no important changes in left ventricular ejection fraction" with antibiotic treatment of Borrelia burgdorferi. In the B burgdorferi group, the mean duration of cardiac symptoms before treatment was 2-9 (0-7) months

Beati, Lorenza

331

Utah Center for Advanced Imaging Research 2014 UCAIR Imaging Symposium Program

  Engineering Websites

Summary: Kim et al. MRI of Left Ventricular Fibrosis to Predict Functional Response to LVAD G. Lawrence Zeng Functional Brain Imaging of Dementia with Lewy Bodies Subgroups Jeffrey Anderson, MD, PhD 13:25-13:40 Melissa P. Lopez-Larson, Lubdha M. Shah, and Jeffrey S. Anderson Functional Imaging Biomarkers of Pediatric

Provancher, William

332

ieee transactions on ultrasonics, ferroelectrics, and frequency control, vol. 54, no. 11, november 2007 2233 Theoretical Quality Assessment of Myocardial

  Biology and Medicine Websites

Summary: the finite-element software Continuity through the National Biomed- ical Computation Resource (NIH P41RR08605 the performance of 2-D my- ocardial elastography based on a previously developed 3- D finite-element model established finite-element, left-ventricular canine models. In a prelim- inary study, the 2-D myocardial

Konofagou, Elisa E.

333

Abstract--The purpose of this study is to investigate the potential of the ensemble empirical mode decomposition

  Biology and Medicine Websites

Summary: account for approximately 95% and left heart ventricle activity (cardiogenic oscillations) for 5-invasively monitor left ventricular stroke volume by ECG triggered ensemble averaging and digital band-pass filtering on the current measured heart rate and require an ECG channel reference. Second, TCG is not adapted to strong non

Fontecave-Jallon, Julie

334

Basic Res Cardiol 97: 177 186 (2002) Steinkopff Verlag 2002 ORIGINAL CONTRIBUTION

  Biology and Medicine Websites

Summary: activity in experimental heart failure í Abstract Activation of the sympathetic nervous system plays an important role in the pathophysiology and progression of congestive heart failure (CHF). The precise of an aorto-caval shunt, or 4 weeks after aortic banding (group C; n = 7). In all CHF models, left ventricular

Just, Armin
2002-01-01

335

Copyright by ICR Publishers 2012 Background and aim of the study: The study aim was

  Biology and Medicine Websites

Summary: the saddle annulus motion of the mitral valve was developed. A series of computational analyses and in that the interaction between the leaflet and the ventricular results in fundamentally distinct transmitral vortex formation patterns. Conclusion: Motion of the mitral saddle annulus along with the leaflet length

Kheradvar, Arash

336

Hindawi Publishing Corporation International Journal of Biomedical Imaging

  Engineering Websites

Summary: motion and intramural strain/stress in response to ventricular blood pressure and bioelectric stimulus viscoelastic passive properties and active contractility of myocardial tissues, based on the chamber pressure diseases are accompanied with impaired myocardium, which typically shows increase in the passive

Virginia Tech

337

December 31, 2013 UNIVERSITY OF RHODE ISLAND

  Engineering Websites

Summary: report should be targeted to an audience that understands the Hodgkin-Huxley model, but not your topic understanding of ion channels [4]. The formulation follows that of the Hodgkin-Huxley model: nonlinear membrane the same way as those in the Hodgkin-Huxley model. The complete embryonic chick ventricular cell model

Vetter, Frederick J.

338

2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSSIMIC) M07-4 Myocardial Blood Flow from Dynamic PET

  Biology and Medicine Websites

Summary: -4 Myocardial Blood Flow from Dynamic PET using Independent Component Analysis Alexander Karpikov, Hemant Tagare) from dynamic PET requires a reproducible and reliable method to obtain left and right ventricular time-activity curves. We propose the use of Independent Component Analysis (ICA) on PET temporal information to segment

Duncan, James S.

339

Lecture notes in Computer Science, vol. 1935, pp. 226-235, Medical Image Computing and Coputer Assisted Intervention MICCAI 2000.

  Biology and Medicine Websites

Summary: boundary. The fuzzy segmentation permits calculation of total ventricular volume as well as determination that electronically interrogates a volume in 3D using a matrix array of transducers instead of a conventional linear. Successes have been reported in conventional ultrasound using circular arc matched filters to find cross

Stetten, George

340

ORIGINAL ARTICLE The Use of Biomedical Sensors to Monitor Capsule

  Engineering Websites

Summary: in patients and even delivering a lifesaving shock if ventricular fibrillation is detected.1­3 Monitoring, notably in the area of glucose measurement for diabetes management.4­6 Still, the majority of implanted situations. Therefore, in these experiments we have implanted these 2 types of sensors into rats and studied

Giurgiutiu, Victor

341

doi:10.1152/ajpheart.01117.2004 289:H569-H577, 2005. First published 25 March 2005;Am J Physiol Heart Circ Physiol

  Engineering Websites

Summary: placed 10 mm apart on the anterior ventricular epicardium. We optically mapped cellular responses). Optical mapping revealed that maximum virtual electrode polar- ization (VEP) was reached at significantly different times for AR and DR of the same duration (P 0.05) for all tested CIs. As a result, VEP for AR were


342

Evaluation and implications of natural product use in preoperative patients: a retrospective review

  University of Kansas - KU ScholarWorks

Summary: ; ventricular arrhythmias with halothane; long-term uses depletes endogenous catecholamines and may cause intraoperative hemodynamic instability; life- threatening interaction with MAOI's At least 24 hours before surgery Garlic Inhibition of platelet... aggregation, increased fibrinolysis, equivocal antihypertensive activity Potential to increase risk of bleeding, especially when combined with other medications that inhibit platelet aggregation At least 7 days before surgery Ginkgo Inhibition of platelet...

King, Allison R.; Russett, Flint S.; Generali, Joyce A.; Grauer, Dennis W.
2009-10-13

343

Autologous bone marrow cells and ischemic cardiomyopathy Jerome Roncalli1

  Physics Websites

Summary: : Intramyocardial stem cell injection in patients with ischemic cardiomyopathy: functional recovery and reverse of ischemic cardiomyopathy. A variety of adult stem and progenitor cells from different sources have already stem cells) in left ventricular scar and border zone improve regional contractility of a chronic

Paris-Sud XI, Université de

344

Visualization of embryonic neural stem cells using Hes promoters in transgenic mice

  Biology and Medicine Websites

Summary: Visualization of embryonic neural stem cells using Hes promoters in transgenic mice Toshiyuki stem cells proliferate in the ventricular zone (VZ) and sequentially give rise to both neurons and glial cells in a temporally and spatially regulated manner, suggesting that stem cells may differ from

McConnell, Susan

345

nature neurOSCIenCe VOLUME 13 | NUMBER 5 | MAY 2010 551 a r t I C l e S

  Biology and Medicine Websites

Summary: osteodysplastic primordial dwarfism type II are caused by mutations in genes encoding centrosome and DNA damage to the ventricular zone in the subventricular zone (SVZ), are thought to produce a majority of cortical neurons2,3. Neurons are also produced by NSCs undergoing neurogenic asym metric divisions. Thus, a balance

Crair, Michael C

346

Universittsmedizin Gttingen Publikationen und Hochschulschriften 2011

  Biology and Medicine Websites

Summary: in a vascular flow model: toward stent-specific recommendations in MR follow-up. NEURORADIOLOGY, 53: 359-65. 8 A (2011) Occlusion of surgical opening of the ventricular system with fibrinogen-coated collagen fleece Parkinson syndrome and healthy controls. HUM BRAIN MAPP, 32: 1905-15. 7. Frölich AMJ, Pilgram-Pastor SM

Gollisch, Tim

347

Paper accepted for presentation at 2002 Joint Meeting of the IEEE EMBS and the BMES, Houston, Texas, 23-26 October 2002. Copyright IEEE 2002. Prediction of Tachyarrhythmia Episodes

  Engineering Websites

Summary: yielded a modulation pattern of the R-R intervals, which was termed "vagal fatigue," that appears-R. The resulting error signal was used to set the "vagal fatigue" indicator. Keywords ­ ventricular fibrillation, VF, tachyarrhythmia, R-R intervals, vagal fatigue, tachycardia, prediction. I. INTRODUCTION


348

1068 VOLUME 42 | NUMBER 12 | DECEMBER 2010 Nature GeNetics A rt i c l e s

  Biology and Medicine Websites

Summary: with QRS duration and cardiac ventricular conduction Nona Sotoodehnia1,2,78*, Aaron Isaacs3,4,78, Paul I W de Bakker5­8,78, Marcus Dörr9,78, Christopher Newton-Cheh10­12,78, Ilja M Nolte13,78, Pim van der

de Bakker, Paul

349

Receptor tyrosine phosphatase zeta/beta in astrocyte progenitors in the developing chick spinal cord

  Biology and Medicine Websites

Summary: Receptor tyrosine phosphatase zeta/beta in astrocyte progenitors in the developing chick spinal chick spinal cord. RPTPZ/b was expressed throughout the ventricular zone (VZ) of the developing spinal a single ,9 kbp RPTPZ/b transcript expressed in the embryonic chick spinal cord, indicating

Richardson, William D.

350

Concepts for interventional MRI and computer assisted surgery in congenital heart diseases

  Computer Technologies and Information Sciences Websites

Summary: is considered the gold standard for quantifying ventricular volumes and blood flow and recent advances in fast imaging techniques made MRI catheterization a reality. The combination of invasive pressures with MRI derived volumes was demonstrated to provide accurate estimates of the endsystolic pressure

Boyer, Edmond

351

Preventing alternans-induced spiral wave breakup in cardiac tissue: An ion-channel-based approach

  Biology and Medicine Websites

Summary: . DOI: 10.1103/PhysRevE.78.031925 PACS number s : 87.19.Hh, 87.19.rp Ventricular fibrillation, a life 3V-SIM by Fenton et al. 18 , set 3. This model has been used to study the effects of "electrotonic

Otani, Niels F.

352

Recovery of Soft Tissue Object Deformation from 3D Image Sequences using Biomechanical Models

  Biology and Medicine Websites

Summary: equations are discretized and solved using the finite element method. We demonstrate the application estimates as described in section 4. The general problem is solved using the finite-element method (section of this method to estimating strains from sequences of in- vivo left ventricular MR images, where we incorporate

Duncan, James S.

353

Meshless Deformable Models for LV Motion Analysis Xiaoxu Wang Dimitis Metaxas

  Biology and Medicine Websites

Summary: cardiac functional analysis us- ing Finite Element Methods (FEM). Spline models based on FEM have also and accuracy. In particular, the model performs well even when the control points (tag intersections function measurements such as the ventricular volumes, tagged MRI can be utilized to recover local heart


354

Basic Res Cardiol . Author manuscript Vascular endothelial dysfunction in Duchenne muscular dystrophy is

  Physics Websites

Summary: dystrophy (GRMD) dogs with left ventricular dysfunction (measured by echocardiography) and in isolated guanosine monophosphate (cGMP) content was analyzed by radioimmunoassay. Compared with controls, GRMD dogs-elicited relaxation was nearly absent in placebo-treated GRMD dogs. This was explained by reduced nNOS and e

Paris-Sud XI, Université de

355

Graphical Simulation of Early Development of the Cerebral Cortex Elizabeth F. Ryder \\Lambda , Lindsey Bullard, Joel Hone Jonas Olmstead, Matthew O. Ward

  Computer Technologies and Information Sciences Websites

Summary: into a database for ease of comparison and hypothesis generation [3]. Simulation of cell growth and motion has on this specification. Cell­based simulation has also been used to study cell patterns in the growth of different typesCortex models the proliferation of progenitor cells in the pseudostratified ventricular epithelium (PVE

Ward, Matthew

356

Ag4V2O6F2 (SVOF): A High Silver Density Phase and Potential New Cathode Material for Implantable Cardioverter Defibrillators

  Chemistry Websites

Summary: sensors to analyze and quantify in situ and/or in vivo vital signs. They also contribute to advances the above-mentioned electrochemical characteristics. ICDs enable the treatment of human ventricular, the transition from a two-cell to a single-cell battery was, from a technological point of view, a significant

Poeppelmeier, Kenneth R.

357

Sequence-independent segmentation of magnetic resonance images Bruce Fischl,a,b,* David H. Salat,a

  Biology and Medicine Websites

Summary: , psychiatric disorders, and healthy aging are all frequently associated with structural changes in the brain in morphometric properties of brain structures. Morphometric changes may include variations in the volume or shape changes in noncortical structures. For example, changes in ventricular or hippocampal volume

Fischl, Bruce

358

Neuron, Vol. 17, 5561, July, 1996, Copyright 1996 by Cell Press Restriction of Late Cerebral Cortical Progenitors

  Biology and Medicine Websites

Summary: , upper-layer is less well characterized. Here, we explore the mech- progenitors were transplanted their developmental potential experimentally, upper-layer progenitor cellswere transplanted back intoThe mammalian cerebral cortex is organized into layers the ventricular zone of younger host brains, during theof neurons

McConnell, Susan

359

Proceedings IEEE ICCV 1995, Pages 687-692 1 A Model-Based Integrated Approach to Track Myocardial

  Biology and Medicine Websites

Summary: improvement in patient treatment. We present a new method of es- timating left ventricular deformation which found on the boundaries of the left ventricle. Velocity informa- tion is obtained from phase contrast magnetic reso- nance images, and boundary information is obtained from shape-based motion tracking

Duncan, James S.

360

Activin A Promotes Progenitor Differentiation into Photoreceptors in Rodent Retina

  Biology and Medicine Websites

Summary: of the embry- onic nervous system. We used both in vitro and in vivo approaches to test for functions to be expressed widely in the developing nervous system. For example, activin A and activin B have been shown is found in the developing ventricular zone of the rat nervous system from E14 to E20). Both activin type

Reh, Thomas A.

361

Exercise Physiology Ethnic Differences in Physiological Cardiac Adaptation to

  Computer Technologies and Information Sciences Websites

Summary: Exercise Physiology Ethnic Differences in Physiological Cardiac Adaptation to Intense Physical Exercise in Highly Trained Female Athletes J. Rawlins, MRCP; F. Carre, PhD; G. Kervio, PhD; M. Papadakis exercise in black female athletes is associated with greater left ventricular hypertrophy and higher

Boyer, Edmond

362

Group B Streptococcal b-Hemolysin/Cytolysin Directly Impairs Cardiomyocyte Viability and Function

  Plasma Physics and Fusion Websites

Summary: of pneumonia, sepsis and meningitis in human newborns [1,2]. Despite recent advances in universal screening, United States of America Abstract Background: Group B Streptococcus (GBS) is a leading cause of neonatal with complete and rapid loss of detectable calcium transients in primary neonatal rat ventricular cardiomyocytes

Nizet, Victor

363

Circ Res. Author manuscript Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C

  Physics Websites

Summary: hearts .1 During exercise or acute emotions, CPVT patients develop life-threatening ventricular using confocal microscopy. In our basal recording conditions (2 Hz stimulation rate), Ca transients[ 2 of this abnormal Ca release was enhanced at faster stimulation rates and by2+ -adrenergic stimulation, which also

Paris-Sud XI, Université de

364

velocity probe andits evaluation," Cardiovascular Res., vol. 1, p. 263, 1967.

  Engineering Websites

Summary: ventricular ejection dynamics in man during rest and exercise,"American Heart Association Mono- (21] D.L. Fry, vol. 1, D.H. Bergel, Ed. New York, 1972, [24] J. Logsdon et al., "Right and left heart ejection of respiration and the various orientations of differentpatients' hearts, and requiresthe sdutionof a 3 X 3matrix

Mitter, Sanjoy K.

365

MSCT Labelling for Pre-Operative Planning in Cardiac Resynchronization Kristell Riouala

  Computer Technologies and Information Sciences Websites

Summary: disorders, improving the heart's performance, the capacity of the patient for exercise and reducing and estimation algorithms. Keywords -- CRT, pre-operative planning, heart labelling, 3-D rendering. 1 coordination in hearts with severe heart failure (HF), sinus rhythm and ventricular conduction delay

Boyer, Edmond

366

Evolution of a Non-Invasive Method for Providing Assistance to the Heart

  Engineering Websites

Summary: Evolution of a Non-Invasive Method for Providing Assistance to the Heart H. S. Soroff, MD and J. Rastegar The primary function of the ventricular chambers of the heart is to provide the proper volume, in the first part of the cardiac cycle, when the heart is relaxed, cardiac diastole, the device exerts

Webster III, Robert James

367

DOI:01.IJIT.02.02. ACEEE Int. J. on Information Technology, Vol. 02, No. 02, April 2012

  Physics Websites

Summary: of this interval is done bytaking into account the heart rate as this interval elongates as heart rate decreases and fibrillation. This tachycardia is often precursor to ventricular fibrillation or stoppage of heart beats normal condition of heart. This wave consists of certain parts named as the P wave, PR interval, QRS

Paris-Sud XI, Université de

368

Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice

  Biotechnology Websites

Summary: , heart rate, QRS duration, and QT intervals remained unchanged in TG-WT mice. Moreover, no spontaneous ventricular arrhythmias were detected in TG-WT hearts. Despite these results, a mild, irregular cardiac in the heart [1­6]. The large peak sodium influx is responsible for excit- ability and conduction


369

Detecting changes in serial myocardial perfusion SPECT: A simulation study

  Mathematics Websites

Summary: with various left ventricular positions, sizes, count rates, and perfusion defect severities using% could be detected with false-positive rates of 15% and 10%, respectively, in single studies if alignment the effects of verapamil on heart failure patients,2 and to investigate long-term effects of angioplasty

Modersitzki, Jan

370

POSTER PRESENTATION Open Access In vivo cardiac diffusion tensor imaging

  Physics Websites

Summary: . The total scan time is about 20 minutes at an average heart rate of 60bpm. The MRI parameters are: TE/TR=51 of the human heart contributes signif- icantly to efficient ventricular function in the presence of disease. In this study, our objective was to obtain in vivo DTI para- meters of the human heart with free

Paris-Sud XI, Université de

371

Eur Heart J . Author manuscript Chronic heart rate reduction with ivabradine improves systolic function of

  Physics Websites

Summary: Eur Heart J . Author manuscript Page /1 11 Chronic heart rate reduction with ivabradine improves the adaptations of left ventricular function and calcium handling to chronic heart rate reduction with ivabradine). Ivabradine reduced heart rate by about 20 and improved both ejection fraction (% + 35 ) and systolic

Paris-Sud XI, Université de

372

UNCORRECTEDPROOF 1 Multivariate tensor-based morphometry on surfaces: Application to mapping

  Biology and Medicine Websites

Summary: ventricular surface differences associated with HIV/AIDS. Using concepts from 24differential geometry and the theory of differential forms, we created mathematical structures known as 25holomorphic one metrics--these retain multivariate information on local surface geometry. We applied 30this framework

Thompson, Paul

373

Many different physiological and environmental stimuli induce mitochondrial proliferation in vertebrate muscles (see

  Biology and Medicine Websites

Summary: . Anemia (i.e. phenylhydrazine treatment) did not alter the specific activities (U·g­1 tissue on seasonal remodeling of muscle. Anemia and cold acclimation both induced a 25­30% increase in relative in relative ventricular mass, neither anemia nor seasonal acclimation had a major influence on the s

McClelland, Grant B.

374

Cognitive Neuroscience Phylogeny of the cortex

  Biology and Medicine Websites

Summary: of pyramidal cells. Evolution of the neocortex led to the present-day layered neocortex, which is similar of cortical pyramidal cells lengthen with neocorticalization. The pyramidal cells with soma in the deepest "units", with their base in the germinal zone of the ventricular wall. Migration of the pyramidal cells

Bressler, Steven L.

375

LETTER doi:10.1038/nature10405 Genetic variants in novel pathways influence blood

  Mathematics Websites

Summary: stimuli. Over one billion people worldwide have hypertension ($140 mm Hg systolic blood pressure or $90 mm was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease blood pressure (SBP), diastolic blood pressure (DBP) and hypertension5,6 . We now report results

Abecasis, Goncalo

376

Stability and Kinetic Properties of C5-Domain from Myosin Binding Protein C and its Mutants

  Physics Websites

Summary: Cardiomyopathy (FHC) is a cardiac disorder characterized by left ventricular hypertrophy. The prevalence of the disease in the population is 0.2% and rep- resents the most common cause of sudden cardiac death in young genes encoding cardiac sarcomeric proteins, the most important of which are the b-myosin heavy chain

Cecconi, Fabio

377

Characterization of multiple spiral wave dynamics as a stochastic predator-prey system Niels F. Otani,1,* Alisa Mo,1

  Physics Websites

Summary: . INTRODUCTION Cardiac rhythm disorders such as ventricular fibrillation are a major source of mortality. These quantities exhibited a number of properties in both simulations and fibrillating canine cardiac tissue in the United States. Many of these disorders may be caused by rotating action potential waves called spiral

Otani, Niels F.

378

Regulated Nuclear Trafficking of the Homeodomain Protein Otx1 in Cortical Neurons

  Biology and Medicine Websites

Summary: Regulated Nuclear Trafficking of the Homeodomain Protein Otx1 in Cortical Neurons Y. Alex Zhang,1 in the rat ventricular zone, and remains cytoplasmic as neurons migrate and begin to differentiate. Nuclear, that the N-terminus of Otx1 is nec- essary for nuclear import, and that a putative nuclear localization

McConnell, Susan

379

Surface-based TBM Boosts Power to Detect Disease Effects on the Brain: An N=804 ADNI Study Yalin Wang1, Yang Song2, Priya Rajagopalan3, Tuo An3, Krystal Liu3, YiYu Chou3,

  Mathematics Websites

Summary: associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI) in 490 subjects (97 AD, 245 MCI, 148 controls) and ventricular differences in 804 subjects scanned as part of the Alzheimer's DiseaseSurface-based TBM Boosts Power to Detect Disease Effects on the Brain: An N=804 ADNI Study Yalin

Wang, Yalin

380

INFECTIVITY AND MULTIPLICATION OF NOSEMA APIS Z. IN THE VENTRICULUS OF THE HONEY BEE

  Physics Websites

Summary: ventriculi 2, 4, 6 and 8 days p.i. the infection normally seemed to spread from the posterior to the anterior epithelium, with infection peaks in the anterior as well as the posterior parts 48 hours after infection that the infection is spread from the anterior to the posterior ventricular parts. In contrast, KELLNER (1980) found

Paris-Sud XI, Université de

381

POSTER PRESENTATION Open Access 4D flow-sensitive MR estimation of pulmonary

  Engineering Websites

Summary: Background Pulmonary arterial hypertension (PAH) is characterized by progressive increase in pulmonary ventricular (RV) function in PAH. Deter- mining PVR from MRI could enable a more complete characterization of RV and PA interactions in PAH. The purpose of this study was to non-invasively estimate PVR from TRV

Chesler, Naomi C.

382

Molecular control of neuronal Hwan Tae Park,1

  Biology and Medicine Websites

Summary: differential dependence on glial cells. At the molecular level, extracellular guidance cues have been, themajorprojectionneuronsofthecerebralcortex,arethought to move from the ventricular zone to the pia along the fibers of radial glial cells not require glial fibers and is a major migrating mode for cells originating in the basal telencephalon (or

Wu, Jane Y.

383

Developmentally Regulated Switching of Titin Size Alters Myofibrillar Stiffness in the Perinatal Heart

  Biology and Medicine Websites

Summary: conditions, such as heart rate, left ventricular dimensions, end-diastolic pressure, and stroke volume Heart Christiane A. Opitz, Mark C. Leake, Irina Makarenko, Vladimir Benes, Wolfgang A. Linke Abstract--Before birth, the compliance of the heart is limited predominantly by extracardiac constraint. Reduction

Leake, Mark C.

384

Schizophrenia Research, 5 (1991) 1033113 SCHIZO 00172

  Biology and Medicine Websites

Summary: -automated segmentation of cerebral spinal fluid (CSF) vs. brain parenchyma in MR scans, and the transformation Medical School, `Deparrment oj"Psychiatric (Brockron VAMC and Massachusetts Mental Health Cenier no significant differences were noted between groups on volumetric measures of ventricular brain ratio or lateral


385

DEVELOPMENT 2575DEVELOPMENT AND DISEASE RESEARCH ARTICLE

  Biology and Medicine Websites

Summary: abnormalities include atrial and ventricular septal defects, as well as conductivity defects and aberrant). Recently, we have shown that depletion of TBX5 in Xenopus leads to profound morphological defects number results from defects in embryonic cardiac cell proliferation. We go on to define the expression

Conlon, Frank

386

RESEARCH Open Access Population-based evaluation of a suggested

  Engineering Websites

Summary: than one code for identification of cases. The two largest categories were "ventricular septal defects classification of congenital heart defects based on the International Paediatric and Congenital Cardiac Code of the overall spectrum of congenital heart defects (CHD) has always been challenging, in part because


387

Engineering AspectsComputational Studies Coupling Pediatric Ventricle Assist Devices to the Fontan

  Engineering Websites

Summary: that are amenable to a single- ventricle repair are the atrial septal defect, an atrioventricular canal defect septal defect, and tricuspid atresia. Surgical treatments10 are pallia- tive, performed in series,* CAROL W. LUCAS, W. JAMES PARKS, AND AJIT P. YOGANATHAN* In pediatric ventricular assist device (VAD

Pekkan, Kerem

388

Proc. Natl. Acad. Sci. USA Vol. 95, pp. 94489453, August 1998

  Biology and Medicine Websites

Summary: -deficient mice die perinatally and have ventricular septal defects. Thus, SDF-1 may be involved in directing die perinatally and display profound defects in the hemato- poietic and nervous systems. CXCR4 the cerebellar anlage. Identical defects are observed in mice lacking SDF-1, suggesting a monogamous relationship

Springer, Timothy A.

389

Original article Spectrum of heart disease associated with murine and

  Biology and Medicine Websites

Summary: , heterozygous Gata4 mutation was associated with atrial and ventricular septal defect (ASD, VSD), endocardial factor GATA4 is essential for heart morphogenesis. Heterozygous mutation of GATA4 causes familial septal defects. However, the phenotypic spectrum of heterozygous GATA4 mutation is not known. In this study, we

Broman, Karl W.

390

Development/Plasticity/Repair Loss of X-Linked Mental Retardation Gene Oligophrenin1 in

  Physics Websites

Summary: Development/Plasticity/Repair Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar words: X-linked mental retardation; ophn1 knock-out; dendritic spines; brain ventricular enlargement

Paris-Sud XI, Université de

391

Influence of periodic diffusive inclusions on the bidomain model Andjela Davidovi1a, 2

  Computer Technologies and Information Sciences Websites

Summary: . [3] · The infarct border zone. After infraction in the heart some number of myocytes die ventricular myocardium (A), infarct border zone (B) and centre (C), 1 week after infarction. [4] I current model. · Develop a model for the infarct scar transiting from the classical bidomain, via our new

Boyer, Edmond

392

Arnaud et al. page 1 Isoprostanes 15-F2t-IsoP and 5-F2t-IsoP are not triggers of myocardial

  Computer Technologies and Information Sciences Websites

Summary: to 30 min global ischaemia, followed by a 120 min reperfusion period. Results. Infarct-to-ventricle zone with both isoprostanes had no cardioprotective effect, the infarct-to-ventricle ratio were respectively 43 infarct size K-H buffer Krebs-Henseleit buffer LVDP left ventricular developed pressure LVEDP left

Boyer, Edmond

393

Jero^me Garot, MD, PhD Joa~o A. C. Lima, MD

  Computer Technologies and Information Sciences Websites

Summary: , 511.12143 Myocardium, infarction, 511.814 Published online 10.1148/radiol.2332031676 Radiology 2004 ventricular MI myocardial infarction 3D three-dimensional 1 From the Department of Medicine, Divi- sion-encoded MR: Comparison with Delayed Contrast-enhanced MR Imaging after Myocardial Infarction Strain

Prince, Jerry L.

394

doi:10.1152/ajpheart.00493.2009 299:H1823-H1831, 2010. First published 17 September 2010;Am J Physiol Heart Circ Physiol

  Engineering Websites

Summary: ventricular systolic function. Changes in the extracellular matrix proteins collagen and elastin have been and elastin content were measured for all groups. Vasoactive studies were also performed with U-46619, Y-27632 in mid-to-high-strain elastic modulus. No significant changes in elastin content or vasoactivity were

Chesler, Naomi C.

395

MODERATED POSTER PRESENTATION Open Access Myocardial T1-mapping for early detection

  Physics Websites

Summary: ventricular myocardial fibrosis in systemic sclerosis Franck Thuny1* , Leila Potton2 , Stanislas Rapacchi3 sclerosis (SSc) related to progres- sive diffuse myocardial fibrosis. Myocardial T1-mapping has recently been proposed as a cardiac magnetic reso- nance (CMR) method to quantify interstitial fibrosis early

Paris-Sud XI, Université de

396

Remote Visualization and Computational Steering of Cardiac Virtual Tissues using gViz

  Computer Technologies and Information Sciences Websites

Summary: victims reached promptly by emergency paramedics [1, 2]. During VF the synchronized, mechanical pumping simulations [4-6] of how an intraventricular scroll wave can break down into a fluctuating number of interacting re-entrant waves. Fig. 1 shows some examples of these behaviours. Virtual ventricular tissues

Brodlie, Ken

397

JOINT ESTIMATION OF CARDIAC KINEMATICS AND MATERIAL PARAMETERS FROM NOISY IMAGING DATA AND UNCERTAIN MECHANICAL MODEL

  Biology and Medicine Websites

Summary: , the distributions of stress are determined by the 3D structure of the ventricular walls, the boundary conditions AND UNCERTAIN MECHANICAL MODEL Huafeng Liu, Edward W.B. Lo, and Pengcheng Shi Biomedical Research Laboratory) computational framework to estimate the cardiac kinematics functions and material model parameters

Shi, Pengcheng

398

Stochastic Tractography in 3-D Images via Nonlinear Filtering and Spherical Clustering

  Engineering Websites

Summary: simulations of arrhythmias could benefit from an electrophysiological model of the heart with a realistic for the propagation of the electrical impulse initiating the contraction of the ventricular myocardium. Modern ex vivo-running Purkinje fibers, which activate endocardial structures such as the papillary muscle. However, tracking

Vidal, René

399

1/4 XXII CBEB 2010 MEDIO DA VARIABILIDADE DO VOLUME SISTLICO POR MEIO DE

  Biology and Medicine Websites

Summary: , Brasília-DF, Brasil e-mail: joaoluiz@pgea.unb.br Abstract: Stroke volume variability provides information stroke volume. We propose a method for measuring left-ventricular stroke volume on a beat-to-beat basis in stroke volume during several autonomic stimuli. Palavras-chave: variabilidade do débito sistólico

Carvalho, João Luiz

400

Analysis of the fibre architecture of the heart by quantitative polarized light microscopy Accuracy, limitations and contribution to the study of the fibre architecture of the ventricles

  Mathematics Websites

Summary: ­ Accuracy, limitations and contribution to the study of the fibre architecture of the ventricles during the orientation of myocardial fibers into the ventricular mass. For each pixel of a horizontal section of the section for each pixel of the section and is accounted for by two angles, the azimuth angle which

Milisic, Vuk

401

MRI predictors of cognitive outcome in early multiple sclerosis Mathilde S.A. Deloire1,2

  Physics Websites

Summary: Deloire 1 MRI predictors of cognitive outcome in early multiple sclerosis Mathilde S.A. Deloire1 tables. Keywords: Multiple sclerosis, Brain atrophy, Ventricular fraction, Cognition, Magnetic resonance for cognitive outcome in early relapsing remitting multiple sclerosis (MS) patients. Methods: Inception Cohort

Paris-Sud XI, Université de

402

CLINICAL RESEARCH Heart failure/cardiomyopathy

  Biology and Medicine Websites

Summary: RESEARCH Heart failure/cardiomyopathy Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure Jianwen Wang, Dirar SBakey Heart Center, The Methodist Hospital, Houston, TX 77030-2717, USA Received 27 September 2007; revised 15

Duncan, James S.

403

ESTIMATING MECHANICAL PROPERTIES OF THE HEART USING DYNAMIC MODELING AND MAGNETIC RESONANCE IMAGING

  Engineering Websites

Summary: ESTIMATING MECHANICAL PROPERTIES OF THE HEART USING DYNAMIC MODELING AND MAGNETIC RESONANCE IMAGING mechanical properties of the heart using magnetic resonance imaging (MRI) tissue-tagging and blood pres- sure, in vivo heart. Clinically, they may be useful for developing ventricular function measures with sufficient

Nehorai, Arye

404

Luca Gentili e-mail: l.gentili@unibo.it

  Engineering Websites

Summary: of a Maglev Artificial Heart This paper is devoted to the development of an advanced controller for a maglev artificial heart: in particular, a magnetically levitated left ventricular assist device is studied and the disturbances from the natural heart are taken into account. The main goal is to define a control action able

Paden, Brad

405

Boundary Element Analysis of Intracardiac Electrogram Sensing

  Mathematics Websites

Summary: of electrical signals is essential to proper functioning of the heart. Action potentials in the heart cause begins in the sino­atrial node above the atria and flows across the heart from the right atrium and ventricles; it is propagated to the bottom of the heart, and finally it radiates throughout the ventricular


406

Name: dhr. prof. dr. J.R. Lahpor Cardiothoracic surgery

  Biology and Medicine Websites

Summary: Medicine Department Division of Heart and Lung Contact details Telephone (+31) 88 755 6179 E-mail address j ventricular assist device: a functional comparison with heart transplantation; Pruijsten R.V., de Jonge N., Kirkels J.H., Klopping C., Doevendans P.A., Ooosterom A., Kemperman H., Lahpor J.R. Neth Heart J 2008

Utrecht, Universiteit

407

INFLUENCES OF POSTNATAL PHYSIOLOGICAL ADJUSTMENTS ON THE CARDIAC ELECTRICAL FIELD

  Physics Websites

Summary: . SCHWARTZE Carl-Ludwig-Institute of Physiology, Karl-Marx-University Leipzig, G.D.R. The electrical heart whose elec- trical heart axis corresponds to the physiologically prepondering left ventricular wall after birth on the direction of the electrical heart axis animal experiments with guinea pigs of va

Paris-Sud XI, Université de

408

Analysis of a Non-linear Partial Difference Equation, and

  Engineering Websites

Summary: States is catastrophic disturbances in electrical rhythms in the heart [7]. Ventricular fibrillation, a particularly lethal phenomenon, consists of the heart being totally ineffectual at pumping blood due to disorganized irregular patterns of electrical activity in the heart. The electrical patterns of excitation

Rand, Richard H.

409

Figure 1: Left ventricle endo-surface segmentation meshes were dissected into two halves, the septum

  Computer Technologies and Information Sciences Websites

Summary: , the septum (on the left) and the free wall (on the right). (a) is from a normal heart, and (b) is from a diseased heart. SHAPE ANALYSIS OF THE LEFT VENTRICULAR ENDOCARDIAL SURFACE AND ITS APPLICATION IN DETECTING *Piedmont Heart Institute, Atlanta, Georgia 30309, USA Introduction The complex 3D geometrical structure

Bhandarkar, Suchendra "Suchi" M.

410

Sedmera Vvoj komorovho myokardu Funkce orgnu je podmnna jeho strukturou. Toto tvrzen nabv zvlstn vznam u srdce, jez je jednm

  Computer Technologies and Information Sciences Websites

Summary: development, and during its morphogenesis must support the circulatory demands of the growing organism in the adult heart. Ventricular conduction system serves above all the coordinated spread of electrical and functional deployment of the various components of cardiac conuction system in the chick embryo, including

Tebbens, Jurjen Duintjer

411

doi:10.1152/ajpheart.01400.2007 294:1753-1766, 2008. First published Feb 8, 2008;Am J Physiol Heart Circ Physiol

  Engineering Websites

Summary: -duration ventricular fibrillation in dogs Chemical ablation of the Purkinje system causes early termination://ajpheart.physiology.org/cgi/content/full/294/4/H1753 can be found at:AJP - Heart and Circulatory PhysiologyaboutAdditional material of the heart, blood vessels, andAJP - Heart and Circulatory Physiology onOctober26,2008ajpheart

MacLeod, Rob S.

412

Elec 331 -Blood Pressure Heart Valves

  Energy Storage, Conversion and Utilization Websites

Summary: Elec 331 - Blood Pressure 1 Heart Valves · Atrio-Ventricular (AV) ­ Bicuspid / Mitral (left - Blood Pressure 2 Phases of the Heart · Systole (Max BP) ­ Ventricle contracted ­ Aorta inflated 331 - Blood Pressure 3 Korotkov Phases / Sounds S D P P Nothing Sharp Swish Faint Nothing 0 1 2-3 4 5

Pulfrey, David L.

413

Mathematical Modeling of Flow-Generated Forces in an In Vitro System of Cardiac Valve Development

  Energy Storage, Conversion and Utilization Websites

Summary: leaflets. A longstanding hypothesis proposes that blood flow- generated shear stress and pressure model that simulates the forces created by blood flow present in a developing chick heart and in our leaflets, which function to prevent regurgitation of blood from the ventricular chamber back

Weidner, John W.

414

Hindawi Publishing Corporation International Journal of Biomedical Imaging

  Engineering Websites

Summary: potency, intra and congenital cardiac lesions, and quantifying ventricular muscle mass, chamber volumes 12819, Pages 1­11 DOI 10.1155/IJBI/2006/12819 Controlled Cardiac Computed Tomography Erwei Bai,1 of Radiology, University of Iowa, Iowa City, IA 52242, USA 2 Controlled Cardiac CT, LLC, Iowa City, IA, 52246

Virginia Tech

415

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research

  Biology and Medicine Websites

Summary: 's personal copy Strain measurement in the left ventricle during systole with deformable image registration q Keywords: Strain Left ventricle Systole Deformable image registration Soft tissue mechanics Finite element registration technique, termed Hyperelas- tic Warping, for left ventricular strain measurement during systole

Veress, Alexander

416

Active Shape Models & Segmentation of the Left Ventricle in Echocardiography

  Computer Technologies and Information Sciences Websites

Summary: of particular interest since it performs the task of pumping oxygenated blood to the entire body images is a task with important diagnostic power. We propose a model-based approach that aims a set of registered training examples. Extraction of important primitives (ventricular walls, valve

Paragios, Nikos

417

Developing a decisiontheoretic network for a congenital heart disease \\Lambda

  Computer Technologies and Information Sciences Websites

Summary: intelligence and statistical decision theory has yielded the framework of decision­theoretic networks [15 theories of decision making under uncertainty. In contrast with the classical decision the theory of decision­ theoretic networks. Section 3 addresses the aspects of ventricular septal defects

Utrecht, Universiteit

418

CIMS Balloon Pump: A Novel Left Ventricle Assist Device (LVAD)

  CiteSeer

Summary: estimated to be at 63,500 every year. The probability of death within one year of diagnosis is 40%, if untreated (1). Heart failure treatment varies from lifestyle change, pharmacological treatment or surgical intervention. For advanced stages HF patients, heart transplant is the gold standard treatment. However, since donors are scarce resulting only 3000 operation/year worldwide, the next best treatment is mechanical heart assist device. 2) Aim & Objectives The aim of this study is to develop mechanical heart assist device specifically for left ventricle i.e. left ventricular assist device (LVAD) system that is able to restore heart health by reverse remodelling (self healing process). It is hypothesized reverse remodelling can be achieved by decreasing load faced by heart and increasing coronary perfusion. As such, objectives of this study are •To develop a prototype of balloon pump •To determine ventricular work reduction •To optimize of balloon pump design, including for in-vivo experiment

Zahran Khudzari; D. Richens; G. D. Tansley

419

References

  CiteSeer

Summary: A noninvasive imaging modality for cardiac electrophysiology and arrhythmias is not yet available for clinical application. Such modality could be used to identify patients at risk, provide accurate diagnosis and guide therapy. Standard noninvasive diagnostic techniques, such as the electrocardiogram (ECG) provide only low-resolution reflection of cardiac electrical activity on the body surface. In my presentation, I will describe the application in humans of a new imaging modality called Electrocardiographic Imaging (ECGI) that noninvasively images cardiac electrical activity on the heart’s epicardial surface. In ECGI, a multielectrode vest (or strips) records 250 body-surface electrocardiograms; then, using geometrical information from a CT scan and an inverse solution to Laplace equation, electrical potentials, electrograms, activation sequences (isochrones) and repolarization patterns are reconstructed on the heart‘s surface. I will show examples of imaged atrial and ventricular activation and ventricular repolarization

C. Ramanathan; R. N. Ghanem; P. Jia; K. Ryu; Y. Rudy; C. Ramanathan; P. Jia; R. N. Ghanem; K. Ryu; Y. Rudy

420

Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord

  CiteSeer

Summary: The glutamate transporter GLAST is localized on the cell membrane of mature astrocytes and is also expressed in the ventricular zone of developing brains. To characterize and follow the GLAST-expressing cells during development, we examined the mouse spinal cord by in situ hybridization and immunohistochemistry. At embryonic day (E) 11 and E13, cells expressing GLAST mRNA were present only in the ventricular zone, where GLAST immunoreactivity was associated with most of the cell bodies of neuroepithelial cells. In addition, GLAST immunoreactivity was detected in radial processes running through the mantle and marginal zones. From this characteristic cytology, GLAST-expressing cells at early stages were judged to be radial glia cells. At E15, cells expressing GLAST mRNA first appeared in the mantle zone, and GLAST-immunopositive punctate or reticular protrusions were formed along the radial processes.

Takashi Shibata; Keiko Yamada; Masahiko Watanabe; Kazuhiro Ikenaka; Keiji Wada; Kohichi Tanaka; Yoshiro Inoue
1997-01-01

421

Angiogenic and Inflammatory Markers of Cardiopulmonary Changes in Children and Adolescents with Sickle Cell Disease

  CiteSeer

Summary: Background: Pulmonary hypertension and left ventricular diastolic dysfunction are complications of sickle cell disease. Pulmonary hypertension is associated with hemolysis and hypoxia, but other unidentified factors are likely involved in pathogenesis as well. Design and Methods: Plasma concentrations of three angiogenic markers (fibroblast growth factor, platelet derived growth factor–BB [PDGF-BB], vascular endothelial growth factor [VEGF]) and seven inflammatory markers implicated in pulmonary hypertension in other settings were determined by Bio-Plex suspension array in 237 children and adolescents with sickle cell disease at steady state and 43 controls. Tricuspid regurgitation velocity (which reflects systolic pulmonary artery pressure), mitral valve E/Edti ratio (which reflects left ventricular diastolic dysfunction), and a hemolytic component derived from four markers of hemolysis and hemoglobin oxygen saturation were also determined. Results: Plasma concentrations of interleukin-8, interleukin-10 and VEGF were elevated in the patients with sickle cell

Xiaomei Niu; Mehdi Nouraie; Andrew Campbell; Sohail Rana; Caterina P. Minniti; Craig Sable; Deepika Darbari; Niti Dham; N. Scott Reading; Josef T. Prchal; Gregory J. Kato; Mark T. Gladwin; Oswaldo L. Castro; Victor R. Gordeuk

422

Tearing of the Mitral Valve during Vent Removal after a Successful Mitral Valve Repair: a Beneficial Role of

  CiteSeer

Summary: In this case, a successful mitral valve repair was confirmed by transesophageal echocardiography (TEE) at the end of a cardiopulmonary bypass. The left ventricular vent was placed through the mitral valve to remove the air after the TEE examination, and on its way out, the left ventricular vent damaged the anterior mitral leaflet (AML). Re-examination of the valve with TEE detected the new mitral valve insufficiency. The CPB was reinstituted, and tearing of the lateral third part of the anterior mitral leaflet was found. This case emphasizes the importance of TEE in the operating room as a continuous monitor, not only to evaluate the result of the cardiac surgery, but also to detect any unpredictable events during the surgery. Key Words: Transesophageal echocardiography, mitral valve insufficiency

Transesophageal Echocardiography; Ji Young Kim; Young Jun Oh; Yong Kyung Lee; Young Lan Kwak
2005-01-01

423

Commentary Vasopressin and ischaemic heart disease: more than coronary vasoconstriction?

  CiteSeer

Summary: During advanced vasodilatory shock, arginine vasopressin (AVP) is increasingly used to restore blood pressure and thus to reduce catecholamine requirements. The AVP-related rise in mean arterial pressure is due to systemic vasoconstriction, which, depending on the infusion rate, may also reduce coronary blood flow despite an increased coronary perfusion pressure. In a murine model of myocardial ischaemia, Indrambarya and colleagues now report that a 3-day infusion of AVP decreased the left ventricular ejection fraction, ultimately resulting in increased mortality, and thus compared unfavourably with a standard treatment using dobutamine. The AVP-related impairment myocardial dysfunction did not result from the increased left ventricular afterload but from a direct effect on cardiac contractility. Consequently, the authors conclude that the use of AVP should be cautioned in patients with underlying

Pierre Asfar; Peter Radermacher
2009-01-01

424

Georg-August-Universitt Gttingen, Bereich Humanmedizin Publikationen und Hochschulschriften 2005

  Biology and Medicine Websites

Summary: ) A new endocardial "over-the-wire" or stylet-driven left ventricular lead: first clinical experience (2005) Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. EUR-surface-potential-maps by utilizing a common 12-lead-ECG device. IEEE T BIO-MED ENG, 52(3): 463-70. 12. Kockskämper J, Zima AV

Gollisch, Tim

425

A Hydro-elastic Model of Hydrocephalus

  CiteSeer

Summary: this paper we construct a model of the brain and ventricular system which is su#ciently complex to reproduce the behaviour of the hydrocephalic brain yet simple enough to be mathematically tractable, and use the model to analyse the onset and treatment of the condition. A review of the general area of application of poroelascticty to the brain may be found in Tenti et al. (2000)

A. Smillie; I. Sobey; Z. Molnar
2004-01-01

426

Case Report Spontaneous Cardiac Hypertrophy in a Crl:CD(SD) Rat

  CiteSeer

Summary: Abstract: Cardiac hypertrophy was observed in a 9-week-old Crl:CD(SD) rat that died unexpectedly. The animal was allocated to the control group of a toxicity study, and no abnormalities in its general conditions, body weight or food intake were observed. Necropsy revealed an increase in heart weight. Gross examination indicated cardiac enlargement with thickening of the right and left ventricular walls. Histopathological examination revealed hypertrophy of the cardiomyocytes in the right and left ventricular walls and the interventricular septum. Electron microscopic examination indicated bizarre nuclei and accumulation of an increased number of various sizes of mitochondria in the perinuclear region of the hypertrophied myocytes. Hypertrophied myocytes connected by intensely folded intercalated disks were also observed. Based on these findings, the animal was diagnosed with cardiac hypertrophy. This is the first case report of cardiac hypertrophy in this strain. (J Toxicol Pathol 2009; 22: 83–87) Key words: SD rat, heart, hypertrophy Cardiac hypertrophy is cellular adaptation of the heart in response to pressure or volume overload that results from hypertension and cardiovascular malformations such as ventricular septal defect (VSD) and valvular heart disease. Cardiac hypertrophy has been reported in several rat models 1–5. For example, cardiac hypertrophy has been experimentally induced in Dahl salt-sensitive rats and rats with constricted aortas. Untreated spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats also develop cardiac hypertrophy. Increased heart weights and thickening of the ventricular wall have been observed in these rats. Crl:CD(SD) (SD) rats have been used increasingly in recent toxicity studies, and background data on these rats have been collected. However, few cases of spontaneous cardiac hypertrophy have been reported in this strain. Herein, we describe a case of spontaneous cardiac hypertrophy in a 9-week-old SD rat that died unexpectedly. This male SD rat was obtained from Charles River

Tomo Suzuki; Shoichi Kado; Minoru Ando; Yuriko Nagata; Shin Iwata; Toshihide Kobayashi; Kazumi Uchida

427

The relationship of physical training and time components of the left ventricle

  Texas A&M University - TxSpace

Summary: cardiac-cycle time components. 3. Highly physical trained individuals have significantly increased resting and post-exercise pre-ejection periods, significantly increased resting electromechanical lag and isovolumetric contraction periods... of Literature III METHODS AND PROCEDURES Selection of Sub3ects Methodology Variables Left Ventricular Time Components Resting Blood Pressure (Systolic and Diastolic) Body Weight . Age Data Analysis 2 3 3 4 5 6 6 7 10 12 14 15 17 17 17 19...

Bradley, Patrick Walton
1976-01-01

428

Classificao de Pacientes Chagsicos com Escalogramas e Redes Neurais Auto-Organizativas

  Biology and Medicine Websites

Summary: indicadores escalográficos, obtidos a partir de escalogramas com função de base DOG. Comprovou-se que os arritmias ventriculares em sinais de ECG, utilizando Redes Neurais do tipo funções radiais de base (radial estatísticas complexas e não-lineares entre dados multidimensionais, em relações geométricas #12;simples, numa

Carvalho, João Luiz

429

Norbert Marwan (marwan@agnld.uni-potsdam.de), Niels Wessel (niels@agnld.uni-potsdam.de) In this study new developed

  Physics Websites

Summary: thus making the investigation of intermittency possible. Recurrence Plot Based Analysis of Heart Rate.5 ± 134.1 ** 9 150 342.4 ± 193.6 216.1 ± 137.1 ** 12 170 353.5 ± 221.4 215.1 ± 138.6 ** DATA Heart rate of ventricular tachy-arrhythmias (VT) in patients with an implanted cardioverter- defibrillator based on heart

Seehafer, Norbert

430

Limit cycles by FEM for a one - parameter dynamical system associated to the Luo - Rudy I model

  CERN Preprints

Summary: An one - parameter dynamical system is associated to the mathematical problem governing the membrane excitability of a ventricular cardiomyocyte, according to the Luo-Rudy I model. Limit cycles are described by the solutions of an extended system. A finite element method time approximation (FEM) is used in order to formulate the approximate problem. Starting from a Hopf bifurcation point, approximate limit cycles are obtained, step by step, using an arc-length-continuation method and Newton's method. Some numerical results are presented.

Bichir, C?t?lin Liviu; Amuzescu, Bogdan; Nistor, Gheorghe; Popescu, Marin; Flonta, Maria-Luiza; Corlan, Alexandru Dan; Svab, Istvan
2011-01-01

431

Mechanical Circulatory Support for End-Stage Heart Failure in Repaired and Palliated Congenital Heart Disease

  CiteSeer

Summary: Abstract: Approximately one in one hundred children is born with congenital heart disease. Most can be managed with corrective or palliative surgery but a small group will develop severe heart failure, leaving cardiac transplantation as the ultimate treatment option. Unfortunately, due to the inadequate number of available donor organs, only a small number of patients can benefit from this therapy, and mortality remains high for pediatric patients awaiting heart transplantation, especially compared to adults. The purpose of this review is to describe the potential role of mechanical circulatory support in this context and to review current experience. For patients with congenital heart disease, ventricular assist devices are most commonly used as a bridge to cardiac transplantation, an application which has been shown to have several important advantages over medical therapy alone or support with extracorporeal membrane oxygenation, including improved survival to transplant, less exposure to blood products with less immune sensitization, and improved organ function. While these devices may improve wait list mortality, the chronic shortage of donor organs for children is likely to remain a problem into the foreseeable future. Therefore, there is great interest in the development of mechanical ventricular assist devices as potential destination therapy for congenital heart disease patients with end-stage heart failure. This review first discusses the experience with the currently available ventricular assist devices in children with congenital heart disease, and then follows to discuss what devices are under development and may reach the bedside soon.

Joseph B. Clark; Linda B. Pauliks; John L. Myers; Akif Ündar

432

The subaortic tendon as a mimic of hypertrophic cardiomyopathy

  CiteSeer

Summary: which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Originally described by Brock and Teare, today hypertrophic cardiomyopathy is clinically defined as left (or right) ventricular hypertrophy without a known cardiac or systemic cause, such as systemic hypertension, Fabry's disease or aortic stenosis. Also appreciated today is the enormous genotypic and phenotypic heterogeneity of this disease with more than 300 mutations over more than 24 genes, encoding various sarcomeric, mitochondrial and calcium-handling proteins, all as genetic causes for hypertrophic cardiomyopathy. Phenotypically, the disease can vary from negligible to extreme hypertrophy, affecting either the left and/or right ventricle in an apical, midventricular or subaortic location. Left ventricular false tendons are thin, fibrous or fibromuscular structures that traverse the left ventricular cavity. Recently, a case report was presented where it was shown that such a false tendon, originating from a subaortic location, was responsible for striking ST-segment elevation on the surface electrocardiogram. In this case report, a case is presented where such a subaortic tendon led to the classic echocardiographic appearance of hypertrophic cardiomyopathy, thus in the assessment of hypertrophic cardiomyopathy, this entity needs to be excluded in order to prevent a false positive diagnosis of hypertrophic cardiomyopathy.

Cardiovascular Ultrasound; James Ker
2009-01-01

433

Bisphenol A and 17b-Estradiol Promote Arrhythmia in the Female Heart via Alteration of Calcium Handling

  CiteSeer

Summary: Background: There is wide-spread human exposure to bisphenol A (BPA), a ubiquitous estrogenic endocrine disruptor that has been implicated as having potentially harmful effects on human heart health. Higher urine BPA concentrations have been shown to be associated with cardiovascular diseases in humans. However, neither the nature nor the mechanism(s) of BPA action on the heart are understood. Methodology/Principal Findings: The rapid (,7 min) effects of BPA and 17b-estradiol (E2) in the heart and ventricular myocytes from rodents were investigated in the present study. In isolated ventricular myocytes from young adult females, but not males, physiological concentrations of BPA or E2 (10 29 M) rapidly induced arrhythmogenic triggered activities. The effects of BPA were particularly pronounced when combined with estradiol. Under conditions of catecholamine stimulation, E2 and BPA promoted ventricular arrhythmias in female, but not male, hearts. The cellular mechanism of the female-specific pro-arrhythmic effects of BPA and E2 were investigated. Exposure to E2 and/or BPA rapidly altered myocyte Ca 2+ handling; in particular, estrogens markedly increased sarcoplasmic reticulum (SR) Ca 2+ leak, and increased SR Ca 2+ load. Ryanodine (10 27 M) inhibition of SR Ca 2+ leak suppressed estrogen-induced triggered activities. The rapid response of female myocytes to estrogens was abolished in an estrogen receptor (ER) b knockout mouse model. Conclusions/Significance: Physiologically-relevant concentrations of BPA and E2 promote arrhythmias in a female-specific

Sujuan Yan; Yamei Chen; Min Dong; Weizhong Song; Scott M. Belcher; Hong-sheng Wang

434

EDITORIAL COMMENT Cardiovascular dynamics in ischemic cardiomyopathy during exercise

  CiteSeer

Summary: Ó The Author(s) 2009. This article is published with open access at Springerlink.com Both echocardiography and cardiac magnetic resonance imaging (CMR) are currently recognized as accurate and reliable means of evaluating cardiac anatomy and ventricular function. Echocardiography is still the mainstay of assessing left ventricular function but over the past years considerable progress has been made in the field of CMR, providing accurate evaluation of left ventricular function particularly in patients with heart failure due to ischemic cardiomyopathy [1–11]. Stress first-pass contrast-enhanced myocardial perfusion CMR can be used to detect subendocardial ischemia and recent studies have demonstrated the high diagnostic accuracy of stress myocardial perfusion CMR for detecting significant coronary artery disease [12–17]. Magnetic resonance angiography (MRA) has been introduced as a method that can provide visualization of all three major coronary arteries, coronary anomalies, coronary bypasses and the aorta within a single three-dimensional acquisition [18–21]. CMR has become the Editorial comment on the article of Wong et al.

E. E. Van Der Wall; J. J. Bax; C. A. Swenne; P. Steendijk; M. J. Schalij

435

Differences in Na and Ca spikes as examined by application of tetrodotoxin, procaine, and manganese

  CiteSeer

Summary: ABSTRACT The effects of tetrodotoxin, procaine, and manganese ions were examined on the Ca spike of the barnacle muscle fiber injected with Cabinding agent as well as on the action potential of the ventricular muscle fiber of the frog heart. Although tetrodotoxin and procaine very effectively suppress the "Na spike " of other tissues, no suppressing effects are found on "Ca spike" of the barnacle fiber, while the initiation of the Ca spike is competitively inhibited by manganese ions. The initial rate of rise of the ventricular action potential is suppressed by tetrodotoxin and procaine but the plateau phase of the action potential is little affected. In contrast the suppressing effect of manganese ions is mainly on the plateau phase. The results suggest that the plateau phase of the ventricular action potential is related to the conductance increase in the membrane to Ca ions even though Na conductance change may also contribute to the plateau. Spike potentials of most excitable tissues such as the squid giant axon (Hodgkin and Katz, 1949) and the skeletal muscle fiber of the frog (Nastuk and Hodgkin,

Susumu Hagiwara; Shigehiro Nakajima
1966-01-01

436

Open Access Management of Cardiac Involvement in NeuroMuscular Diseases: Review

  CiteSeer

Summary: Abstract: Neuromuscular Diseases are a heterogeneous molecular, clinical and prognosis group. Progress has been achieved in the understanding and classification of these diseases. Cardiac involvement in neuromuscular diseases namely conduction disorders, ventricular dilatation and dilated cardiomyopathy with its impact on prognosis, is often dissociated from the peripheral myopathy. Therefore, close surveillance is mandatory in the affected patients. In this context, preventive therapy (beta-blockers and angiotensin converting enzyme inhibitors) has been recently recommended in the most common Neuromuscular Diseases, Duchenne Muscular Dystrophy and Myotonic Dystrophy. Key Words: Muscular dystrophy, cardiomyopathy, sudden cardiac death.

Rachida Bouhouch; Tarik Elhouari; Latifa Oukerraj; Ibtissam Fellat; Jamila Zarzur; Rajaa Bennani; Mhamed Arharbi; Service De Cardiologie B; Chu Ibn; Sina Rabat

437

Commentary Debate: Do all patients with heart failure require implantable defibrillators to prevent sudden death?

  CiteSeer

Summary: Sudden death is a major cause of mortality in patients with ventricular dysfunction. The highest risk occurs among patients with less severe functional impairment. Current methods of risk stratification are inadequate, and a rational therapy for prevention of sudden death is not available. The implantable cardioverter-defibrillator (ICD) has proven to be more effective than drugs in reducing sudden-death risk in some subsets of patients. Empiric ICD therapy, targeting the general population with mild to moderate heart failure, will maximize the impact of such a strategy to prevent sudden death and improve long-term survival.

Henry H Hsia; Mariell L Jessup; Francis E Marchlinski
2000-01-01

438

Investigations on the cause of electrocardiogram changes during dehydration

  Texas A&M University - TxSpace

Summary: Goats. Exp. I and Exp, II Goats 36 2. EKG Change Associated with Confinement and Dehydration. Goat 139. Lead II Amplitude Changes in Dehydrated Goat After Oral Administration of NH4CI. Lead II 3B 4. EKG Amplitude Increase in Dog i Following... the cardio~ vascular response of irradiated rats. The mean height of the R wave in an unipolar central chest lead was in- creased as was the manifest ventricular activation po- tential calculated from limb data. There was no in- crease in P or T wave...

Clark, Donald Ray
1966-01-01

439

Velocidade de Propagação de Enchimento

  CiteSeer

Summary: Introdução: O enfarte agudo do miocárdio (EAM) induz disfunção diastólica do ventrículo esquerdo (VE), a qual condiciona a evolução clínica e o prognóstico. A velocidade de propagação do enchimento precoce (VPEP) tem demonstrado ser um parâmetro de função diastólica com uma excelente correlação com a constante de relaxamento "tau " e é relativamente independente da pré e pós-carga. Objectivo: O objectivo foi a avaliação do relaxamento ventricular esquerdo, em pacientes com EAM submetido a terapêutica de reperfusão urgente. Material e métodos: Foram estudados doentes (dts) internados por EAM com

Precoce Estudo; Função Diastólica; A Reperfusão Aguda; Rev Port Cardiol

440

Myotonic Dystrophy Initially Presenting as Tachycardiomyopathy Successful Catheter Ablation of Atrial Flutter

  CiteSeer

Summary: Copyright © 2010 S. Asbach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Myotonic dystrophy is a genetic muscular disease that is frequently associated with cardiac arrhythmias. Bradyarrhythmias, such as sinus bradycardia and atrioventricular block, are more common than tachyarrhythmias. Rarely, previously undiagnosed patients with myotonic dystrophy initially present with a tachyarrhythmia. We describe the case of a 14-year-old boy, who was admitted to the hospital with clinical signs and symptoms of decompensated heart failure and severely reduced left ventricular function. Electrocardiography showed common-type atrial flutter with 2: 1 conduction resulting in a heart rate of 160 bpm. Initiation of medical therapy for heart failure as well as electrical cardioversion led to a marked clinical improvement. Catheter ablation of atrial flutter was performed to prevent future cardiac decompensations and to prevent development of tachymyopathy. Left ventricular function normalized during followup. Genetic analysis confirmed the clinical suspicion of myotonic dystrophy as known in other family members in this case. 1.

unknown authors

441

Functional data analytic approach of modeling ECG T-wave shape to measure cardiovascular behavior

  CERN Preprints

Summary: The T-wave of an electrocardiogram (ECG) represents the ventricular repolarization that is critical in restoration of the heart muscle to a pre-contractile state prior to the next beat. Alterations in the T-wave reflect various cardiac conditions; and links between abnormal (prolonged) ventricular repolarization and malignant arrhythmias have been documented. Cardiac safety testing prior to approval of any new drug currently relies on two points of the ECG waveform: onset of the Q-wave and termination of the T-wave; and only a few beats are measured. Using functional data analysis, a statistical approach extracts a common shape for each subject (reference curve) from a sequence of beats, and then models the deviation of each curve in the sequence from that reference curve as a four-dimensional vector. The representation can be used to distinguish differences between beats or to model shape changes in a subject's T-wave over time. This model provides physically interpretable parameters characterizing T-wave sh...

Zhou, Yingchun; 10.1214/09-AOAS273
2010-01-01

442

Growth factor-induced mobilization of cardiac progenitor cells reduces the risk of arrhythmias, in a rat model of chronic myocardial infarction. PLoS One

  CiteSeer

Summary: Heart repair by stem cell treatment may involve life-threatening arrhythmias. Cardiac progenitor cells (CPCs) appear best suited for reconstituting lost myocardium without posing arrhythmic risks, being commissioned towards cardiac phenotype. In this study we tested the hypothesis that mobilization of CPCs through locally delivered Hepatocyte Growth Factor and Insulin-Like Growth Factor-1 to heal chronic myocardial infarction (MI), lowers the proneness to arrhythmias. We used 133 adult male Wistar rats either with one-month old MI and treated with growth factors (GFs, n = 60) or vehicle (V, n = 55), or sham operated (n = 18). In selected groups of animals, prior to and two weeks after GF/V delivery, we evaluated stress-induced ventricular arrhythmias by telemetry-ECG, cardiac mechanics by echocardiography, and ventricular excitability, conduction velocity and refractoriness by epicardial multiple-lead recording. Invasive hemodynamic measurements were performed before sacrifice and eventually the hearts were subjected to anatomical, morphometric, immunohistochemical, and molecular biology analyses. When compared with untreated MI, GFs decreased stress-induced arrhythmias and concurrently prolonged the effective refractory period (ERP) without affecting neither the duration of

Leonardo Bocchi; Monia Savi; Gallia Graiani; Stefano Rossi; Aldo Agnetti; Francesca Stillitano; Costanza Lagrasta; Silvana Baruffi; Roberta Berni; Caterina Frati; Mario Vassalle; Elisabetta Cerbai; Emilio Macchi; Donatella Stilli; Federico Quaini; Ezio Musso
2011-01-01

443

Departments of Medicine and

  CiteSeer

Summary: Background and Objectives: The reliability and usefulness of the right ventricular (RV) Tei index (RTX) remains controversial because it has not been possible to simultaneously measure RV inflow and outflow. However, dual pulsed-wave Doppler (DPD) enables flow velocities to be obtained at different sampling sites simultaneously. In this study we evaluated the feasibility and reliability of RTX values obtained by DPD (RTXDPD). Subjects and Methods: Forty-one patients who underwent cardiac catheterization and echocardiography for RV volume or pressure overloading conditions were evaluated. Symptomlimited exercise treadmill testing with expired gas analysis was performed and maximal exercise capacity was measured. Results: RTX by conventional flow Doppler (RTXCFD, 0.262±0.164) was similar to RTXDPD (0.253±0.117, p=NS), whereas RTX by tissue Doppler echocardiography (RTXTDE, 0.447±0.125) was significantly larger than RTXDPD (p<0.001). Based on multiple regression analysis, maximal exercise capacity was independently related to RTXDPD (?=-0.60, p<0.001), mid-RV dimension (?=-0.26, p=0.012), left ventricular ejection fraction (?=0.22, p=0.023), and early diastolic tricuspid annular velocity (?=0.21, p=0.048). Conclusion: It is feasible and reliable to evaluate RV function using RTXDPD values. However, to evaluate the clinical usefulness of RTXDPD, additional studies are required with a large number of patients and long-term follow-up. (Korean Circ J 2010;40:391-398)

unknown authors

444

DOI 10.1007/s12245-010-0183-y CLINICAL IMAGES Early recognition and management of Lyme carditis

  CiteSeer

Summary: A 20-year-old man presented to the emergency department with 2 weeks of migratory arthralgias and several macular blanching rashes. A photograph taken by the patient upon initial eruption of the rash was presented during evaluation (Fig. 1). The lesions were suspicious for erythema migrans (Fig. 2). Upon review of systems, the patient earlier reported a brief episode of palpitations. Electrocardiogram revealed first-degree atrioventricular (AV) block (PR interval 320 ms). He was admitted for telemetry monitoring and intravenous ceftriaxone. He developed asymptomatic Wenckebach which progressed to a high-grade second-degree AV block (Fig. 3). Echocardiography showed global ventricular dysfunction (ejection fraction of 35%). Cardiac magnetic resonance imaging (MRI) revealed inflammation around the AV node (Fig. 4). Lyme carditis was confirmed after Western blot revealed Borrelia burgdorferi antibodies. The patient had resolution of symptoms 4 weeks after intravenous ceftriaxone treatment. Follow-up echocardiography, 5 months later, revealed normal left ventricular function (ejection fraction of 55%). Patients with PR intervals greater than 300 ms are at risk for developing high-grade heart block [1, 2]. They can progress from first-degree heart block into complete Fig. 1 Mobile phone image of erythema migrans at time of initial eruption

Pholaphat Charles Inboriboon; P. C. Inboriboon
2010-01-01

445

www.ipej.org 26 Original Article Comparison of the Electrocardiographic Features of Complete Left Bundle Branch Block in Patients with

  CiteSeer

Summary: Background: Differentiating ischemic (ILVD) from nonischemic left ventricular dysfunction (NILVD) is important prognostically and therapeutically but might be difficult clinically. The differentiating role of electrocardiographic (ECG) features in the presence of left bundle-branch block (LBBB) is debatable on differentiating ILVD from NILVD. Objective: The present study assessed whether there is the role of certain ECG features in differentiating ILVD from NILVD in the presence of the complete LBBB. Methods and Results: Patients who had LBBB were divided into two groups based on the presence and type of left ventricular dysfunction; (1) ILVD group (49 patients; 20 female; age: 65 ± 11 years) and (2) NILVD group (49 patients; 22 female; age: 59 ± 12 years), and numerous ECG features were compared. Most of these ECG features did not show any difference between the groups except for following ECG findings; the voltage of R wave in V6 were statistically higher in NILVD group compared ILVD group (p: 0.03); the depression of the ST-J point by more than 0.2 mV in V6 were also frequently observed in NILVD group compared ILVD group (5 / 10 % vs 19 / 39 % , p: 0.001); and the notching in the ascending or descending limb of the S

Nonischemic Left; Ventricular Dysfunction

446

Review Article Cardiac Resynchronization Therapy In Heart Failure: Recent Advances And New Insights

  CiteSeer

Summary: Newer non-pharmacological therapies for heart failure are being evaluated for patients of congestive heart failure (CHF). Mechanical support with left ventricular assist devices and heart transplantation are reserved for the minority of patients who have severely decompensated heart failure. Despite these therapeutic advances, it is generally accepted that current therapies do not adequately address the clinical need of patients with heart failure, and additional strategies are being developed. Cardiac resynchronization therapy (CRT) is a new modality that involves synchronization of ventricular contraction and has shown a lot of promise in managing symptomatic patients of CHF who are on optimal medical therapy and have interventricular conduction delay (IVCD). It has improved exercise tolerance and NYHA functional class in such patients in sinus rhythm and a recent meta-analysis has also shown mortality benefits in CHF. Recently benefits of CRT have also been observed in CHF patients who do not have wide QRS complexes on electrocardiogram (EKG). It has also been shown to benefit drug refractory angina in CHF. Recent studies have also focused on the combined use of CRT and implantable cardioverter defibrillator (ICD) and it has shown encouraging results. Our aim in this descriptive review is to define practice guidelines and to improve clinicians ' knowledge of the available published clinical evidence, concentrating on few randomized controlled trials.

unknown authors

447

Fluidic Operational Amplifier for Mock Circulatory Systems

  CiteSeer

Summary: Abstract—For the development of cardiovascular devices and the study of the dynamics of blood flow through the cardiovascular system, hardware fluidic models are commonly used to minimize animal experiments and clinical trials. These systems, called “mock circulatory systems, ” are also critical for the development of ventricular assist devices. The passive and active elements in these systems are frequently “hard-plumbed ” and are difficult to modify in experimental studies. Therefore, we propose a concept of novel fluidic operational amplifier comprised of a high-gain feedbackcontrolled gear pump. With pressure being the analog of voltage, design with the fluidic op-amp is analogous to electrical op-amp circuit design. Initial computer and hardware simulation results demonstrate that the device may be programmed for use in mock circulatory systems to emulate the function of the energy sources (the ventricles) or passive networks (hemodynamic loads). Index Terms—Feedback-controlled gear pump, fluidic operational amplifier, impedance, mock circulatory systems. I.

Kwan-woong Gwak; Brad E. Paden; Myounggyu D. Noh; James F. Antaki

448

A pseudo active kinematic constraint for a biological living soft tissue: an effect of the collagen network

  CERN Preprints

Summary: Recent studies in mammalian hearts show that left ventricular wall thickening is an important mechanism for systolic ejection and that during contraction the cardiac muscle develops significant stresses in the muscular cross-fiber direction. We suggested that the collagen network surrounding the muscular fibers could account for these mechanical behaviors. To test this hypothesis we develop a model for large deformation response of active, incompressible, nonlinear elastic and transversely isotropic living soft tissue (such as cardiac or arteries tissues) in which we include a coupling effect between the connective tissue and the muscular fibers. Then, a three-dimensional finite element formulation including this internal pseudo-active kinematic constraint is derived. Analytical and finite element solutions are in a very good agreement. The numerical results show this wall thickening effect with an order of magnitude compatible with the experimental observations.

Bourdarias, Christian; Ohayon, Jacques
2008-01-01

449

Recent Patents on Cardiovascular Drug Discovery, 2006, 1, 1-20 1 Novel Molecular Targets in the Treatment of Cardiac Hypertrophy

  CiteSeer

Summary: Abstract: Left ventricular hypertrophy represents the heart’s response to increased biomechanical stress such as arterial hypertension or valvular heart disease. Cardiac hypertrophy has traditionally been considered a compensatory mechanism required to normalize wall tension and to maintain cardiac output. However, recent clinical studies as well as several animal models have shown that sustained cardiac hypertrophy is rather a maladaptive process, ultimately leading to heart failure and sudden death independent of the underlying cause of hypertrophy. Throughout the past decade, much effort has thus been spent on deciphering the molecular signaling pathways mediating cardiac growth. Identification of novel molecules regulating cardiac hypertrophy could offer the basis for a new generation of cardiovascular drugs. In this review we focus on recent insights into hypertrophic signaling and consider current and emerging approaches to inhibit hypertrophy with the ultimate goal to prevent or delay the onset of heart failure and sudden death in patients.

Mark Luedde; Hugo A. Katus; Norbert Frey

450

Life-Threatening Cardiac Manifestations of Pheochromocytoma

  CiteSeer

Summary: Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Pheochromocytoma is a catecholamine-secreting tumor of the adrenal glands, usually with benign manifestations, whose typical clinical presentation includes the triad of headache, palpitations and diaphoresis. However, a wide range of signs and symptoms may be present. In the cardiovascular system, the most common signs are labile hypertension and sinus tachycardia. Systolic heart failure and ST-segment deviations mimicking myocardial infarction have also been reported, as well as QT interval prolongation and, rarely, ventricular tachycardia. We describe a challenging diagnosis of pheochromocytoma with many cardiovascular manifestations, which could have been missed due to the absence of typical symptoms. 1.

Article Id; Luiz R. Leite; Paula G. Macedo; Simone N. Santos; Luiz Quaglia; Cezar E. Mesas
2010-01-01

451

Cardiac Resynchronization Therapy in Children

  CiteSeer

Summary: Abstract: Cardiac Resynchronization therapy has become an important management tool in adults with heart failure and dilated cardiomyopathy. The role of CRT in children with CHF is still unclear. Evidence is slowly emerging in the pediatric cardiology literature that CRT may have an important and useful role in certain select populations with CHF. These include patients with complete heart block who develop pacing-induced cardiomyopathy, certain forms of congenital heart disease associated with systemic ventricular failure (even if the systemic ventricle is a morphologic RV) and in patients with idiopathic dilated cardiomyopathy. Studies in children supporting the use of CRT include many case reports, a few studies of CRT in post-operative patients, and one multi-center registry reporting the use of CRT in children. These papers will be summarized.

Anjan S. Batra; Seshadri Balaji

452

Copyright © 2012 Termedia & Banach Corresponding author:

  CiteSeer

Summary: Cardiac pacing is a proven therapy of cardiac conduction disturbances and an effective treatment modality in many cardiac arrhythmias. Implantable cardiac defibrillators (ICDs) are particularly beneficial for selected groups of patients with a history of severe ventricular arrhythmias or at a high risk of sudden cardiac death. Despite their potential lifesaving properties, both pacemakers and ICDs are associated with a number of complications. The most frequent include pneumothorax; myocardial perforation; lead malposition, displacement or fracture due to excessive manipulation of the device by the patient (Twiddler’s syndrome) [1]. Another group of complications comprises infections: from the pacemaker pocket to bacterial endocarditis with its origin on leads or the tricuspid valve, failure of leads to pace and/or sense appropriately, erosion of the pacemaker site or its leads, and thrombotic events with the most frequently observed subclavian vein thrombosis [2]. In the era of massive anticoagulation and antiplatelet therapy bleeding complications are not uncommon,

Marek Banaszewski; Janina St?pi?ska; Prof Janina; St?pi?ska Md
2012-01-01

453

Adjuvant Use of Ivabradine in Acute Heart Failure due to Myocarditis

  CiteSeer

Summary: which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We report two cases of young men in whom acute heart failure due to myocarditis was diagnosed. The patients had been transferred to the intensive care unit (ICU) with commencing symptoms of acute heart failure and consecutive multiorgan failure for further treatment and to evaluate the indication for implantation of a ventricular assist device or for high urgent orthotopic heart transplantation. In both patients, the I f-channel inhibitor ivabradine was administered off-label to provide selective heart rate reduction, and thus support hemodynamic stabilization. Though currently considered off-label use in patients suffering from severe hypotension and acute heart failure, the use of ivabradine may beneficially influence outcome by allowing optimization of the patient’s heart rate concomitant to initial measures of clinical stabilization. 1.

Article Id; Jennifer Franke; Dorothee Schmahl; Stephanie Lehrke; Regina Pribe; Raffi Bekeredjian; Andreas O. Doesch; Hugo A. Katus; Christian Zugck

454

Open Access Percutaneous Recanalization of Coronary Chronic Total Occlusions: Current Devices and Specialized Wire Crossing Techniques

  CiteSeer

Summary: Treatment of coronary chronic total occlusions (CTOs) remains a challenging obstacle, posing a considerable barrier to achieving successful complete revascularization. By nature of their complexity, percutaneous CTO interventions are associated with lower rates of procedural success, higher complication rates, greater radiation exposure and longer procedure times compared with non-CTO interventions. In the last few years, development in guidewires, devices and the emergence of new techniques from Japanese centers resulted in higher success rates in the hands of experienced operators. The impact of drug eluting stents on restenosis has improved long-term outcomes after successful recanalization. Successful revascularization is associated with improved long-term survival, reduced symptoms, improved left ventricular function and reduced need for coronary bypass surgery. This paper reviews the current devices and specialized crossing techniques of percutaneous intervention to relieve CTOs. (Korean Circ J

Hee-yeol Kim Md

455

Indeterminacy of Spatiotemporal Cardiac Alternans

  CERN Preprints

Summary: Cardiac alternans, a beat-to-beat alternation in action potential duration (at the cellular level) or in ECG morphology (at the whole heart level), is a marker of ventricular fibrillation, a fatal heart rhythm that kills hundreds of thousands of people in the US each year. Investigating cardiac alternans may lead to a better understanding of the mechanisms of cardiac arrhythmias and eventually better algorithms for the prediction and prevention of such dreadful diseases. In paced cardiac tissue, alternans develops under increasingly shorter pacing period. Existing experimental and theoretical studies adopt the assumption that alternans in homogeneous cardiac tissue is exclusively determined by the pacing period. In contrast, we find that, when calcium-driven alternans develops in cardiac fibers, it may take different spatiotemporal patterns depending on the pacing history. Because there coexist multiple alternans solutions for a given pacing period, the alternans pattern on a fiber becomes unpredictable. Usin...

Zhao, Xiaopeng
2007-01-01

456

Assessment of Risk for Sudden Cardiac Death in Patients With Dilative

  CiteSeer

Summary: Introduction Non-ischaemic dilative cardiomyopathy (DCM) and coronary artery disease (CAD) are the most common heart diseases of those associated with an increased risk for sudden cardiac death. Combining classical tools of risk stratification like the HolterECG, electrophysiological stimulation and the evaluation of left ventricular function enables us, at least in CAD patients, to identify candidates who may profit from prophylactic antiarrhythmic therapy (primary prevention) [1]. However, new methods are searched that are more effective in CAD patients, and are also able to guide antiarrhythmic therapy in DCM patients in which the classical risk stratifiers cannot predict the risk of sudden death with adequate accuracy [2, 3]. As the course of myocardial repolarisation seems to be essential in the genesis of malignant arrhythmias, some techniques concentrate on regional or temporal differences of the t-wave in the electrocardiogram [4, 5]. Using multi-channel magnetocardiographic r

Cardiomyopathy And Coronary; P. Gödde; K. Czerski; R. Agrawal; D. Sancar; D. Robinson; H. -p. Schultheiss; S. Behrens

457

Abstract UPDATE ARTICLE Diabetic Cardiomyopathy: Evidences, Pathophysiology, and Therapeutic Considerations

  CiteSeer

Summary: The very existence of diabetic cardiomyopathy has always been a contentious issue. Strong evidences are now coming to fore favouring its existence. Clinical studies have confirmed the association of diabetes with left ventricular dysfunction, independent of hypertension, coronary artery disease and valvular heart disease. Though diastolic dysfunction of the LV has been regarded as a hallmark of early stage of the disease, new echocardiographic techniques have demonstrated systolic dysfunction also to be present early in the disease course. Several mechanisms have been implicated in the pathophysiology of diabetic cardiomyopathy. These include metabolic alterations, myocardial fibrosis, small vessel disease, endothelial dysfunction and cardiac autonomic neuropathy. There are no definite guidelines for treatment of the disease. However, good glycaemic control, use of ACE inhibitors and calcium blockers are viable options.

unknown authors

458

A model-based integrated approach to track myocardial deformation using displacement and velocity constraints

  CiteSeer

Summary: Accurate estimation of heart wall dense field motion and deformation could help to better understand the physiological processes associated with ischemic heart diseases, and to provide significant improvement in patient treatment. We present a new method of estimating left ventricular deformation which integrates instantaneous velocity information obtained within the mid-wall region with shape information found on the boundaries of the left ventricle. Velocity information is obtained from phase contrast magnetic resonance images, and boundary information is obtained from shape-based motion tracking of the endo- and epicardial boundaries. The integration takes place within a continuum biomechanical heart model which is embedded in a finite element framework. We also employ a feedback mechanism to improve tracking accuracy. The integration of the two disparate but complementary sources overcomes some of the limitations of previous work in the field which concentrates on motion estimation from a single image-derived source. 1

Pengcheng Shi; Glynn Robinson; R. Todd Constable; Albert Sinusas; James Duncan
1995-01-01

459

Mathematical modeling applied to the left ventricle of heart

  CERN Preprints

Summary: Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac architecture, and then study the resulting fibers of activation that propagate through the myocardium. In our paper, we have attempted to create a novel software capable of demonstrate left ventricular (LV) model in normal hearts. Method: Echocardiography was performed on 70 healthy volunteers. Data evaluated included: velocity (radial, longitudinal, rotational and vector point), displacement (longitudinal and rotational), strain rate (longitudinal and circumferential) and strain (radial, longitudinal and circumferential) of all 16 LV myocardial segments. Using these data, force vectors of myocardial samples were estimated by MATLAB software, interfaced in the echocardiograph system. Dynamic orientation contraction (through the cardiac cycle) of every individual myocardial fiber could ...

Ranjbar, Saeed
2014-01-01

460

ECG beats classification using waveform similarity and RR interval

  CERN Preprints

Summary: This paper present an electrocardiogram (ECG) beat classification method based on waveform similarity and RR interval. The purpose of the method is to classify six types of heart beats (normal beat, atrial premature beat, paced beat, premature ventricular beat, left bundle branch block beat and right bundle branch block beat). The electrocardiogram signal is first denoised using wavelet transform based techniques. Heart beats of 128 samples data centered on the R peak are extracted from the ECG signal and thence reduced to 16 samples data to constitute a feature. RR intervals surrounding the beat are also exploited as feature. A database of annotated beats is built for the classifier for waveform comparison to unknown beats. Tested on 46 records in the MIT/BIH arrhythmia database, the method shows classification rate of 97.52%.

Ka, Ahmad Khoureich
2011-01-01

461

Distribution of Action Potential Duration and T-wave Morphology: a Simulation Study

  CERN Preprints

Summary: The results of a simulation study of the action potential duration (APD) distribution and T-wave morphology taking into account the midmyocardial cells (M-cells) concept are described. To investigate the effect of M-cells we present a computer model in which ion channel action potential formulations are incorporated into three-dimensional whole heart model. We implemented inhomogeneous continuous action potential duration distribution based on different distributions of maximal slow delayed rectifier current conductance. Using the proposed action potential distribution procedure midmural zeniths with longest action potential length were created as islands of model cells in the depth of thickest areas of ventricular tissue. Different spatial functions on layer indexes were simulated and their influences on electrocardiogram waveforms were analyzed. Changing parameters of ion channel model we varied duration of minimal and maximal action potential and investigated T-wave amplitude, Q-Tpeak and QT intervals vari...

Ryzhii, Elena; Wei, Daming
2009-01-01

462

REVIEW Lercanidipine in hypertension

  CiteSeer

Summary: Abstract: Lercanidipine is a lipophilic, dihydropyridine calcium antagonist with a long receptor half-life. Its slow onset of action helps to avoid reflex tachycardia associated with other dihydropyridines (DHPs). It produces even and sustained blood pressure lowering with once-daily dosing. It has equivalent antihypertensive efficacy to many other agents and is effective as initial monotherapy or in combination. Efficacy has been demonstrated in elderly as well as younger patients and also in the presence of other risk factors. Lercanidipine is well tolerated with DHP-associated adverse effects occurring early in treatment. The incidence of pedal edema and subsequent withdrawals has been found to be lower with lercanidipine than with amlodipine or nifedipine gastrointestinal transport system. Preclinical and preliminary clinical findings suggest lercanidipine may have beneficial effects on atherosclerosis and left ventricular hypertrophy. The efficacy and tolerability profiles of lercanidipine make it a suitable choice for treating hypertension in a wide range of affected patients.


463

Controlling spatiotemporal chaos in excitable media by local biphasic stimulation

  Nonlinear Sciences (arXiv)

Summary: Controlling spatiotemporal chaos in excitable media by applying low-amplitude perturbations {\\em locally} is of immediate applicability, e.g., in treating ventricular fibrillation, a fatal disturbance in the normal rhythmic functioning of the heart. We look at a mechanism of control by the local application of a series of biphasic pulses, i.e., involving both positive and negative stimulation. This results in faster recovery of the medium, making it possible to overdrive the chaos by generating waves with frequency higher than that possible with only positive pulses. This provides the simplest and most general understanding of the effectiveness of biphasic stimulation in controlling fibrillation and allows designing optimal waveshapes for controlling spatiotemporal chaos.

Johannes Breuer; Sitabhra Sinha
2004-06-21

464

Heart-induced movements in the thorax as detected by MRI

  CERN Preprints

Summary: In order to provide information for the use of radar in diagnostics a qualitative map of movements in the thorax has been obtained. This map was based on magnetic resonance image sequences of a human thorax during suspended respiration. The movements were measured using two distinct techniques. Segmentation provided measures of aorta dilatation and displacements, and image edge detection indicated other movements. The largest heart movements were found in the anterior and left regions of the heart with in-plane displacements on the order of 1 cm and which caused lung vessels displacements on the order of 2-3mm especially on the left side due to the heart ventricular. Mechanical coupling between the heart and aorta caused aorta displacements and shape distortions. Despite this coupling, aorta dilatations most likely reflected blood pressure variations.

Solberg, Lars Erik; Fosse, Erik; Hol, Per Kristian
2014-01-01

465

Scroll-Wave Dynamics in Human Cardiac Tissue: Lessons from a Mathematical Model with Inhomogeneities and Fiber Architecture

  CiteSeer

Summary: Cardiac arrhythmias, such as ventricular tachycardia (VT) and ventricular fibrillation (VF), are among the leading causes of death in the industrialized world. These are associated with the formation of spiral and scroll waves of electrical activation in cardiac tissue; single spiral and scroll waves are believed to be associated with VT whereas their turbulent analogs are associated with VF. Thus, the study of these waves is an important biophysical problem. We present a systematic study of the combined effects of muscle-fiber rotation and inhomogeneities on scroll-wave dynamics in the TNNP (ten Tusscher Noble Noble Panfilov) model for human cardiac tissue. In particular, we use the three-dimensional TNNP model with fiber rotation and consider both conduction and ionic inhomogeneities. We find that, in addition to displaying a sensitive dependence on the positions, sizes, and types of inhomogeneities, scroll-wave dynamics also depends delicately upon the degree of fiber rotation. We find that the tendency of scroll waves to anchor to cylindrical conduction inhomogeneities increases with the radius of the inhomogeneity. Furthermore, the filament of the scroll wave can exhibit drift or meandering, transmural bending, twisting, and break-up. If the scroll-wave filament exhibits weak meandering, then there is a fine balance between the anchoring of this wave at the inhomogeneity and a disruption of wave-pinning by fiber rotation. If this filament displays strong meandering, then again the anchoring is suppressed by fiber rotation; also, the scroll wave can be eliminated from most of the layers only to be regenerated by a seed wave. Ionic inhomogeneities can also lead to an

Rupamanjari Majumder; Alok Ranjan Nayak; Rahul P

466

Dynamics of cell migration from the lateral ganglionic eminence in the rat. J Neurosci 16:6146--6156

  CiteSeer

Summary: From previous developmental studies, it has been proposed that the neurons of the ventrolateral cortex, including the primary olfactory cortex, differentiate from progenitor cells in the lateral ganglionic eminence. The objective of the present study was to test this hypothesis. The cells first generated in the forebrain of the rat migrate to the surface of the telencephalic vesicle by embryonic day (E) 12. Using [ 3 H]thymidine, we found that most of these cells contributed to the formation of the deep layer III of the primary olfactory cortex. To study the migratory routes of these cells, we made localized injections of the carbocyanine fluorescent tracers DiI and DiA into various parts of the lateral ganglionic eminence in living embryos at E12–E14 and subsequently maintained the embryos in a culture device for 17–48 hr. After fixation, most migrating cells were located at the surface of the telencephalic vesicle, whereas others were seen coursing tangentially into the preplate. Injections made at E13 and in fixed tissue at E15 showed that migrating cells follow radial glial fibers extending from the ventricular zone of the lateral ganglionic eminence to the ventrolateral surface of the telencephalic vesicle. The spatial distribution of radial glial fibers was studied in Golgi preparations, and these observations provided further evidence of the existence of long glial fibers extending from the ventricular zone of the lateral ganglionic eminence to the ventrolateral cortex. We conclude that cells of the primary olfactory cortex derive from the lateral ganglionic eminence and that some early generated cells migrating from the lateral ganglionic eminence transgress the cortico-striatal boundary entering the preplate of the neocortical primordium. Key words: cell migration; lateral ganglionic eminence; cortico-striatal sulcus; rat embryo culture; Golgi method; autoradiography; primary olfactory cortex During embryonic development, migrating neurons reach their positions in the cortical layers following guidance cues provided by radial glial fibers (Rakic, 1971, 1972, 1985; Nowakowski and

J. A. De Carlos; L. López-mascaraque; F. Valverde
1996-01-01

467

Clinical Course and Outcome of Children with Single Ventricle Physiology at King Chulalongkorn Memorial Hospital

  CiteSeer

Summary: Background: Children with single ventricle physiology comprise 10 % of all children with congenital heart disease (CHD) and one-third of children with cyanotic CHD seen at King Chulalongkorn Memorial Hospital. The prognosis of these children is generally thought to be poor, but no study of the outcome has previously been done in this hospital and in Thailand. Objectives: To study the clinical course and outcome of children with single ventricle physiology at King Chulalongkorn Memorial Hospital during the current era. Material and Method: One hundred and seventeen patients with single ventricle physiology were initially seen at this hospital during the year 1999-2001. Retrospective chart reviews were carried out in 90 children with available medical records. The status of the patients was determined in 2003 at clinic visits, by phone calls and mail. Results: The main diagnoses were tricuspid atresia (TA, n = 10), pulmonary atresia with intact ventricular septum (PA/IVS, n = 16), single ventricle associated with cardiac malposition or heterotaxy syndrome (malpo-sition, n = 35), hypoplastic left heart syndrome (HLHS, n = 11) and other complex single ventricle (others, n = 18). Most children did not have other major anomalies. Survival of patients with TA and PA/IVS was approximately 92 and 87 % at 1 and 4 years, respectively. For patients in the other three groups, 1 and 4 year

Apichai Khongphatthanayothin Md; Kanokorn Rattanawilaisak Md; Vichai Benjacholamas Md; Chule Numchaisiri Md; Boonchu Sirichonkolthong Md; Pairoj Chotivitayatarakorn Md; Pornthep Lertsapcharoen Md

468

Rate Control Management of Atrial Fibrillation: May a Mathematical Model Suggest an Ideal Heart Rate?

  CERN Preprints

Summary: Background. Despite the routine prescription of rate control therapy for atrial fibrillation (AF), clinical evidence demonstrating a heart rate target is lacking. Aim of the present study was to run a mathematical model simulating AF episodes with a different heart rate (HR) to predict hemodynamic parameters for each situation. Methods. The lumped model, representing the pumping heart together with systemic and pulmonary circuits, was run to simulate AF with HR of 50, 70, 90, 110 and 130 bpm, respectively. Results. Left ventricular pressure increased by 56.7%, from 33.92+-37.56 mmHg to 53.15+-47.56 mmHg, and mean systemic arterial pressure increased by 27.4%, from 82.66+-14.04 mmHg to 105.29+-7.63 mmHg, at the 50 and 130 bpm simulations, respectively. Stroke volume (from 77.45+-8.5 to 39.09+-8.08 mL), ejection fraction (from 61.1+-4.4 to 39.32+-5.42%) and stroke work (SW, from 0.88+-0.04 to 0.58+-0.09 J) decreased by 49.5, 35.6 and 34.2%, at the 50 and 130 bpm simulations, respectively. In addition, oxygen co...

Anselmino, Matteo; Camporeale, Carlo; Saglietto, Andrea; Gaita, Fiorenzo; Ridolfi, Luca
2015-01-01

469

Review Chlorination Disinfection By-Products in Drinking Water and Congenital Anomalies: Review and Meta-Analyses

  CiteSeer

Summary: Objectives: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide recommendations for future studies. Data s o u r c e s a n d extraction: We included all published epidemiologic studies that evaluated a relationship between an index of DBP exposure (treatment, water source, DBP measurements, and both DBP measurements and personal characteristics) and risk of congenital anomalies. When three or more studies examined the same exposure index and congenital anomaly, we conducted a metaanalysis to obtain a summary risk estimate comparing the highest exposure group with the lowest exposure group. When five or more studies examined total trihalomethane (TTHM) exposure and a specific congenital anomaly, we conducted a meta-analysis to obtain exposure–response risk estimates per 10 µg/L TTHM. Data synthesis: For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM [17%; 95 % confidence interval (CI), 3–34] based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95 % CI, 21–107), but this was

Mark J. Nieuwenhuijsen; David Martinez; James Grellier; James Bennett; Nicky Best; Nina Iszatt; Martine Vrijheid; Mireille B. Toledano

470

Review Autoimmune and infectious skin diseases that target desmogleins By Masayuki AMAGAI *1,†

  CiteSeer

Summary: Abstract: Desmosomes are intercellular adhesive junctions of epithelial cells that contain two major transmembrane components, the desmogleins (Dsg) and desmocollins (Dsc), which are cadherin-type cell–cell adhesion molecules and are anchored to intermediate filaments of keratin through interactions with plakoglobin and desmoplakin. Desmosomes play an important role in maintaining the proper structure and barrier function of the epidermis and mucous epithelia. Four Dsg isoforms have been identified to date, Dsg1–Dsg4, and are involved in several skin and heart diseases. Dsg1 and Dsg3 are the two major Dsg isoforms in the skin and mucous membranes, and are targeted by IgG autoantibodies in pemphigus, an autoimmune disease of the skin and mucous membranes. Dsg1 is also targeted by exfoliative toxin (ET) released by Staphylococcus aureus in the infectious skin diseases bullous impetigo and staphylococcal scalded skin syndrome (SSSS). ET is a unique serine protease that shows lock and key specificity to Dsg1. Dsg2 is expressed in all tissues possessing desmosomes, including simple epithelia and myocardia, and mutations in this gene are responsible for arrhythmogenic right ventricular cardiomyopathy/dysplasia. Dsg4 plays an important adhesive role mainly in hair follicles, and Dsg4 mutations cause abnormal hair development. Recently, an active disease model for pemphigus was generated by a unique approach


471

Artificial Selection for Whole Animal Low Intrinsic Aerobic Capacity Co-Segregates with Hypoxia-Induced Cardiac Pump Failure

  CiteSeer

Summary: Oxygen metabolism is a strong predictor of the general health and fitness of an organism. In this study, we hypothesized that a divergence in intrinsic aerobic fitness would co-segregate with susceptibility for cardiovascular dysfunction. To test this hypothesis, cardiac function was assessed in rats specifically selected over nineteen generations for their low (LCR) and high (HCR) intrinsic aerobic running capacity. As an integrative marker of native aerobic capacity, run time to exhaustion between LCR and HCR rats had markedly diverged by 436 % at generation nineteen of artificial selection. In vivo assessment of baseline cardiac function by echocardiography and catheter-based conductance micromanometry showed no marked difference in cardiac performance. However, when challenged by exposure to acute hypoxia, cardiac pump failure occurred significantly earlier in LCR rats compared to HCR animals. Acute cardiac decompensation in LCR rats was exclusively due to the development of intractable irregular ventricular contractions. Analysis of isolated cardiac myocytes showed significantly slower sarcomeric relaxation and delayed kinetics of calcium cycling in LCR myocytes compared to HCR myocytes. This study also revealed that artificial selection for low native aerobic capacity is a novel pathologic stimulus that results in myosin heavy chain isoform switching in the heart as shown by increased levels of b-MHC in LCR rats. Together, these results provide evidence that alterations in sub-cellular calcium handling and MHC isoform composition are associated with susceptibility to

Nathan J. Palpant; Michael L. Szatkowski; Wang Wang; Dewayne Townsend; Fikru B. Bedada; Lauren G. Koch; Steven L. Britton; Joseph M. Metzger

472

Vortex formation and instability in the left ventricle

  CERN Preprints

Summary: We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging (MRI) data of a healthy human subject. The left ventricular kinematics is modeled via a cell-based activation methodology, which is inspired by cardiac electro-physiology and yields physiologic LV wall motion. In the fluid dynamics videos, we describe in detail the three-dimensional structure of the mitral vortex ring, which is formed during early diastolic filling. The ring starts to deform as it propagates toward the apex of the heart and becomes inclined. The trailing secondary vortex tubes are formed as the result of interaction between the vortex ring and the LV wall. These vortex tubes wrap around the circumference and begin to interact with and destabilize the mitral vortex ring. At the end of diastole, the vortex ring impinges on the LV wall and the large-scale int...

Le, Trung; Coffey, Dane; Keefe, Daniel
2011-01-01

473

www.ipej.org 36 Editorial Biventricular Pacing in Congestive Heart Failure

  CiteSeer

Summary: Congestive heart failure (CHF) is a common, debilitating and usually lethal condition responsible for enormous burden on health care. The recent trials have shown improvement in morbidity and mortality with ACE inhibitors and beta blockers 1-3. However, despite this the overall prognosis remains dismal. The other alternative of cardiac transplantation has several limitations including the donor organ scarcity. In view of this gloomy prognosis, several alternative strategies are being explored, one of which has been pacing for heart failure. In this form of therapy pacing is used in absence of the conventional bradyarrhthymic indications with an attempt to lead to optimization of AV delay and co-ordination of ventricular contraction. In 1990, Hochleitner et al 4 reported clinical improvement in patients with severe heart failure awaiting cardiac transplantation with implantation of a physiologic dual-chamber pacemaker (pacing at right atrium and right ventricle) with a programmed short atrioventricular (AV) delay. Brecker et al 5 in 1992 reported similar observations. However, in a randomized cross over design,with larger number of patients there was no significant improvement in the NYHA class or ejection fraction 6. Sack et al 7 and Guide et al reported similar negative results. Consequently, it is difficult to advocate dual chamber pacing for heart failure management.

Balbir Singh

474

Outcome of Heart Failure with Preserved Ejection Fraction: A Multicentre Spanish Registry

  CiteSeer

Summary: Abstract: Background: Studies on clinical features, treatment and prognosis of patients with congestive heart failure (CHF) and preserved left ventricular ejection fraction (LVEF) are few and their results frequently conflicting. Aims: To investigate the characteristics and long term prognosis of patients with CHF and preserved ( ? 45%) LVEF. Methods and Results: We conducted a prospective multicentre study with 4720 patients attended in 62 heart failure clinics from 1999 to 2003 in Spain (BADAPIC registry). LVEF was preserved in 30 % patients. Age, female gender, prevalence of atrial fibrillation, hypertension and non-ischaemic cardiopathy were all significantly greater in patients with preserved LVEF. Mean follow-up was 40±12 months. Mortality and other cardiovascular complication rates during follow up were similar in both groups. On multivariate analysis ejection fraction was not an independent predictor for mortality. Survival at one and five years was similar in both groups (79 % and 59 % for patients with preserved LVEF and 78 % and 57 % for those with reduced LVEF, respectively). Conclusions: In the BADAPIC registry, a high percentage of heart failure patients had preserved LVEF. Although clinical differences were seen between groups, morbidity and mortality were similar in both groups.

Juan C. Castillo; Manuel P. Anguita

475

unknown title

  CiteSeer

Summary: • What is the evidence regarding the role of diuretics in the management of hypertension and chronic heart failure? • What is the comparative evidence for effectiveness and harms for different diuretics? • What is the comparative evidence for diuretics for benefits and harms within subgroups of patients? Conclusions: • Thiazide diuretics improve mortality and stroke in hypertensive patients. Thiazides are recommended as first line blood pressure lowering agents by the Joint National Committee on Prevention, Detection, Evaluation and Treatment of high Blood Pressure (JNC 7) treatment guidelines in adults 5 and by other national treatment guidelines in children 6, adolescents 6 and the elderly 7. • There is insufficient evidence demonstrating efficacy and safety differences among different thiazide diuretics. • Loop diuretics lower blood pressure modestly but play a role in heart failure patients with reduced left ventricular ejection fraction (LVEF) who are symptomatic with fluid retention. They are recommended over thiazide diuretics in severe heart failure. In this patient population, the American College of Cardiology Foundation/American Heart Association (ACCF/AHA) gives them a class I recommendation for treatment. (Level of evidence: C) • There is insufficient evidence comparing efficacy and safety of different loop diuretics. One small study provided low strength evidence to suggest a lower mortality with torsemide compared to furosemide/other diuretics. • Potassium sparing diuretics, specifically aldosterone antagonists, reduce heart failure hospitalization and decrease mortality in patients with LVEF < 35%. ACCF/AHA heart failure treatment guidelines include a class I recommendation for aldosterone antagonists in this subset of heart failure patients (Level

unknown authors

476

Recompensation of Heart and Kidney Function after Treatment with Peritoneal Dialysis in a Case of Congestive Heart Failure

  CiteSeer

Summary: Copyright © 2011 Lars P. Kihm et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We report the case of a 57-year-old woman suffering from congestive heart failure. Due to refractory congestions despite optimised medical treatment, the patient was listed for heart transplantation and peritoneal dialysis was initiated. Peritoneal dialysis led to a significant weight loss, reduction of hyperhydration and extracellular water obtained by bioimpedance measurement, and a significant improvement in clinical and echocardiographic examination. Furthermore, residual kidney function increased during the long-term followup, and subsequently peritoneal dialysis was ceased. Pulmonary artery pressure and left ventricular ejection fraction remained stable and the patient did well. This case demonstrates the possibility of treating hyperhydration due to congestive heart failure with peritoneal dialysis resulting in recompensation of both heart and kidney functions. 1. Background Chronic congestive heart failure is an entity that may lead to progressive chronic kidney disease, then classified as cardi orenal syndrome type 2 [1]. The pathophysiology of renal dysfunction in the setting of advanced cardiac failure is not yet well understood; however, haemodynamic issues seem

Article Id; Lars P. Kihm; Vinzent Hankel; Christian Zugck; Vedat Schwenger
2011-01-01

477

REVIEW Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failure

  CiteSeer

Summary: Abstract: Despite significant improvement in therapy and management, heart failure remains a worrisome disease state that is especially problematic in special populations. African Americans suffer a disproportionately higher prevalence of heart failure when compared to other populations. It has been recently demonstrated that vasodilator therapy using the combination of isosorbide dinitrate (ISDN) and hydralazine (HYD) as an adjunct to background evidence-based therapy appears to display the strongest signal of benefit in reducing mortality and morbidity in the African American population. Through review of the retrospective and more recent prospective data, we will focus on the benefit of ISDN-HYD as adjunctive therapy for use in African Americans with systolic heart failure on concomitant appropriate evidence based therapy. This review also closely examines some of the potential contributions to endothelial dysfunction in African Americans, and the relationship of vascular homeostasis and nitric oxide. The role of oxidative stress in left ventricular dysfunction will also be explored as a reduction of oxidative stress offers particular promise in the management of heart failure. Although neurohormonal blockade has been responsible for notable event reductions in patients with systolic heart failure, the addition of ISDN-HYD, vasodilator therapy that enhances nitric oxide and reduces oxidative stress, further improves quality of life and survival in African American patients with heart failure. These findings strongly imply that nitric oxide enhancement and/or oxidative stress reduction may be important new therapeutic directions in the management of heart failure.

Melvin R Echols; Clyde W Yancy; Correspondence Clyde; W Yancy

478

Lesson 1, Volume 13—Understanding and Managing the Patient With Acute and Chronic Heart Failure

  CiteSeer

Summary: 2. Know the epidemiology of heart failure in the United States. 3. Recognize the multiple etiologies of heart failure in the United States. 4. Understand the appropriate diagnostic evaluation for patients with heart failure. 5. Know the appropriate therapeutic strategy for patients with heart failure. Key words congestive heart failure; diagnosis; epidemiology; left-ventricular systolic dysfunction; prognosis; therapy Abbreviations ACE=angiotensin-converting enzyme Heart failure is one of the most common problems seen in the practices of physicians who care for adults. In hospitalized Medicare patients, heart failure is the most frequently cited diagnosis-related group. Heart failure prevalence increases with age; it ranges from 3 to 20 persons per 1,000 when all ages are considered, but when only persons>65 years of age are considered, the prevalence of heart failure lies between 30 and 130 per 1,000. 1 The crude incidence for heart failure, unadjusted for age, ranges from 1 to 5 cases per 1,000 population per year with a steep increase associated with advancing age. The incidence rate for persons>75 years of age is approximately 40 per 1,000 population per year. Etiology Hypertension was formerly the most common etiology for heart failure. Coronary artery disease has recently moved into the first

S. Alpert

479

RESEARCH ARTICLE Truncation of NHEJ1 in a Patient With Polymicrogyria

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Summary: Polymicrogyria (PMG) is a common malformation of the human cerebral cortex for which both acquired and genetic causes are known. Although genetic heterogeneity is documented, only one gene is currently known to cause isolated PMG. To clone new genes involved in this type of cerebral malformation, we studied a fetus presenting a defect of cortical organization consisting of a polymicrogyric cortex and neuronal heterotopia within the white matter. Karyotype analysis revealed that the fetus was carrier of a balanced, de novo, chromosomal translocation t(2;7)(q35;p22). Cloning and sequencing of the two translocation breakpoints reveals that the chromosomal rearrangement disrupts the coding region of a single gene, called NHEJ1, Cernunnos, orXLF, in 2q35. The NHEJ1 gene was recently identified as being responsible for autosomal recessive immunodeficiency with microcephaly. Using quantitative PCR experiments, we show that a truncated transcript is expressed in the polymicrogyric patient cells, suggesting a potential dominant negative effect possibly leading to a different phenotype. We performed in situ hybridization on human embryos and showed that the NHEJ1 transcript is preferentially expressed in the telencephalic ventricular and subventricular zones, consistent with the phenotype of the affected individual. In the human adult central nervous system (CNS),

Vincent Cantagrel; Anne-marie Lossi; Steven Lisgo; Chantal Missirian; Ana Borges; Nicole Philip; Carla Fern; Carlos Cardoso; Dominique Figarella-branger; Anne Moncla; Susan Lindsay; William B. Dobyns; Laurent Villard

480

Positive Inotropic Action of Insulin on Piglet Heart'

  CiteSeer

Summary: Piglets of 1 day to 12 weeks of age were prepared for evaluation of myocardial contractility by measurement of left ventricular dP/dt max under constant hemodynamic conditions. Practolol (1 mg/kg) was given to each animal to provide beta adrenergic blockade. In 12 piglets given crystallin insulin (40 units), arterial glucose fell from 102 to 22 mg % after 75 min. This was accompanied by an increase of dP/dt max to 138 % of initial values within 30 min. The positive inotropic effect persisted for the duration of the study. Eight control animals and two piglets given glucagon (50 ug/kg) showed no significant change. After the 75-min study period, each animal was made hypoxic by ventilation with N2. The time of onset and severity of hypoxic left heart failure in piglets given insulin did not differ from control animals. It is concluded that insulin augments myocardial contractility in the piglet and that this property is independent of adrenergic mechanims or glucagon contamination. Insulin administration apparently does not diminish cardiac depression engendered by acute hypoxia. Insulin has long been recognized to have a number of effects on the cardiovascular system. Bayliss et al. demonstrated that the heart-lung preparation was maintained in good condition for longer periods with the addition of glucose and insulin to the

Robert P. Rieker; John C. Lee; S. Evans Downing

481

Review Article Metabolic and Cardiovascular Effects of Ghrelin

  CiteSeer

Summary: Copyright © 2010 Manfredi Tesauro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized as a preprohormone and then proteolytically processed to yield a 28-amino acid peptide. This peptide was originally reported to induce growth hormone release; large evidence, however, has indicated many other physiological activities of ghrelin, including regulation of food intake and energy balance, as well as of lipid and glucose metabolism. Ghrelin receptors have been detected in the hypothalamus and the pituitary, but also in the cardiovascular system, where ghrelin exerts beneficial hemodynamic activities. Ghrelin administration acutely improves endothelial dysfunction by increasing nitric oxide bioavailability and normalizes the altered balance between endothelin-1 and nitric oxide within the vasculature of patients with metabolic syndrome. Other cardiovascular effects of ghrelin include improvement of left ventricular contractility and cardiac output, as well as reduction of arterial pressure and systemic vascular resistance. In addition, antinflammatory and antiapoptotic actions of ghrelin have been reported both in vivo and in vitro. This review summarizes the most recent findings on the metabolic and cardiovascular effects of ghrelin through GH-dependent and-independent mechanisms and the possible role of ghrelin as a therapeutic molecule for treating cardiovascular diseases. 1.

Manfredi Tesauro; Francesca Schinzari; Miriam Caramanti; Renato Lauro; Carmine Cardillo

482

Immunoadsorption Therapy for Patients with Dilated Cardiomyopathy and Heart Failure

  CiteSeer

Summary: Abstract: Several autoantibodies directed against cardiac cellular proteins including G-protein-linked receptors, contractile proteins and mitochondrial proteins, have been identified in patients with dilated cardiomyopathy (DCM). Among these autoantibodies, anti-?1-adrenoreceptor (AR) antibodies have long been discussed in terms of their pathogenetic role in DCM. Anti-?1-AR antibody-positive patients with DCM showed significant deterioration of NYHA functional class as well as reduced cardiac function compared to those in autoantibody-negative patients. Various studies with a limited number of patients indicate that the use of immunoadsorption to eliminate immunoglobulin G (IgG) significantly improves cardiac performance and clinical status in heart failure patients. Since removal of autoantibodies of the IgG3 subclass induces hemodynamic improvement and an increase in the left ventricular ejection fraction, antibodies belonging to IgG3 such as anti-?1-AR antibodies might play an important role in reducing cardiac function in patients with DCM. According to a recent report, however, the effect of hemodynamic improvement by immunoadsorption threapy was similar among patients who were positive and negative for anti-?1-AR antibodies, indicating that the beneficial effects of immunoadsorption might be not directly associated with the selective elimination of the ?1-AR autoantibodies. Immunoadsorption therapy is a new therapeutic option for patients with DCM and heart failure, but further investigations are required to elucidate the specific antigens of cardiac autoantibodies responsible for the hemodynamic effects. Key Words: Cardiomyopathy, adrenoreceptor, autoantibody, immunoadsorption, heart failure.

Uichi Ikeda; Hiroki Kasai; Atsushi Izawa; Jun Koyama; Yoshikazu Yazaki; Masafumi Takahashi; Makoto Higuchi; Chang-sung Koh; Keiji Yamamoto

483

Cat Heart Muscle in Vitro VI. Potassium exchange in papillary muscles

  CiteSeer

Summary: ABSTRACT The exchange of cell K with K 42, JK, has been measured in cat right ventricular papillary muscle under conditions of a steady state with respect to intracellular K concentration. Within the limits of the measurement, all of cell K exchanged at a single rate. Cells from small cats are smaller and have larger surface/volume ratios than cells from large cats. The larger surface/ volume ratio results in larger flux values. J increases in an approximately linear manner as the external K concentration is increased twentyfold, from 2.5 to 50 mM, at constant intracellular K concentration. The permeability for K ions, Px, calculated from the influx and membrane potential, remains very nearly constant over this range of external K concentrations. JK is not affected by replacement of 02 by N2, or by stimulated contractions at 60 per minute, but K influx decreases markedly in 10-6 M and 10- 6 M ouabain. Previous papers from this laboratory have described the behavior of cellular ion concentrations, cell volume, and resting transmembrane potential difference of cat papillary muscles under various conditions (1, 2). The present report

Jon Goerke; Ernest Page

484

Shape versus size: Improved understanding of the morphology of brain structures

  CiteSeer

Summary: Abstract. Standard practice in quantitative structural neuroimaging is a segmentation into brain tissue, subcortical structures, fluid space and lesions followed by volume calculations of gross structures. On the other hand, it is evident that object characterization by size does only capture one of multiple aspects of a full structural characterization. Desirable parameters are local and global parameters like length, elongation, bending, width, complexity, bumpiness and many more. In neuroimaging research there is increasing evidence that shape analysis of brain structures provides new information which is not available by conventional volumetric measurements. This motivates development of novel morphometric analysis techniques answering clinical research questions which have been asked for a long time but which remained unanswered due to the lack of appropriate measurement tools. Challenges are the choice of biologically meaningful shape representations, robustness to noise and small perturbations, and the ability to capture the shape properties of populations that represent natural biological shape variation. This paper describes experiments with two different shape representation schemes, a finescale, global surface characterization using spherical harmonics, and a coarsely sampled medial representation (3D skeleton). Driving applications are the detection of group differences of amhygdala-hippocampal shapes in schizophrenia and the analysis of ventricular shape similarity in a mono/dizygotic twin study. The results clearly demonstrate that shape captures information on structural similarity or difference which is not accessible by volume analysis. Improved global and local structure characterization as proposed herein might help to explain pathological changes in neurodevelopment/neurodegeneration in terms of their biological meaning. 1.

Guido Gerig; Martin Styner; Martha E. Shenton; Jeffrey A. Lieberman
2001-01-01

485

Please send correspondence to:

  CiteSeer

Summary: Information about left ventricular (LV) mechanical performance is of critical importance in understanding the etiology of ischemic heart disease. Regional measurements derived from non–invasive imaging to assist in assessing this performance have been in use for decades, and certain parameters derived from these measurements often are useful clinically, as they correlate to some extent with gross physiological hypotheses. However, relatively little work has been done to date to carefully understand the relationship of regional myocardial injury to the local mechanical performance of the heart as derived from image data acquired non-invasively for a particular patient in 3 spatial dimensions over time. This paper describes efforts to take advantage of recent developments in 3D non-invasive imaging and biome-chanical modeling to design an integrated computational platform capable of assembling a variety of displacement and velocity data derived from each image frame to deform a vol-umetric model representation of a portion of the myocardium. A brief description of both the reasoning behind this strategy is put forth, as well as an overview of the approach and some initial results are described.

James Duncan, Ph.D.; Pengcheng Shi, Ph.D.; Todd Constable, Ph.D.; Albert Sinusas; James S. Duncan, Ph.D.

486

training and chronic heart failure

  CiteSeer

Summary: Chronic heart failure (CHF) is a complex syndrome characterised by progressive decline in left ventricular function, low exercise tolerance and raised mortality and morbidity. Regular exercise participation has been shown to be a safe and effective treatment modality in the majority of CHF patients, partially reversing some of the maladaptations evident in myocardial and skeletal muscle function, and resulting in improvements in physical fitness and quality of life, and perhaps reduced mortality. The volume and intensity of exercise that is recommended depends on the syndrome severity, however in most patients it should consist of a combination of low-to-moderate intensity aerobic (endurance) exercise on most days of the week and individually prescribed low-to-moderate intensity resistance (strength) training at least twice per week. Additionally, all patients should be closely monitored prior to and during exercise for contraindications by an appropriately trained health professional. The purpose of this statement is to inform and guide exercise practitioners and health professionals in the safe and effective

Steve E. Selig A; Itamar Levinger A; Andrew D. Williams C; Neil Smart D; David J. Holl; Andrew Maiorana F; Daniel J. Green H; David L. Hare B

487

THE ORIGIN AND DIFFERENTIATION OF MICROGLIAL CELLS DURING DEVELOPMENT

  CiteSeer

Summary: AbstractÐSome authors claim that microglia originate from the neuroepithelium, although most now believe that microglial cells are of mesodermal origin, and probably belong to the monocyte/macrophage cell line. These cells must enter the developing central nervous system (CNS) from the blood stream, the ventricular space or the meninges. Afterward microglial cells are distributed more or less homogeneously through the entire nervous parenchyma. Stereotyped patterns of migration have been recognized during development, in which long-distance tangential migration precedes radial migration of individual cells. Microglial cells moving through the nervous parenchyma are ameboid microglia, which apparently di€erentiate into rami®ed microglia after reaching their de®nitive location. This is supported by the presence of cells showing intermediate features between those of ameboid and rami®ed microglia. The factors that control the invasion of the nervous parenchyma, migration within the developing CNS and di€erentiation of microglial cells are not well known. These phenomena apparently depend on environmental factors such as soluble or cell-surface bound molecules and components of the extracellular matrix. Microglial cells within the developing CNS are involved in clearing cell debris and withdrawing misdirected or transitory axons, and presumably support cell survival and neurite growth. # 1998

Miguel A. Cuadros; Julio Navascueâ S
1998-01-01

488

Review Article Peripartum Cardiomyopathy: Review of the Literature

  CiteSeer

Summary: Peripartum cardiomyopathy (PPCM) is a rare but serious form of cardiac failure affecting women in the last months of pregnancy or early puerperium. Clinical presentation of PPCM is similar to that of systolic heart failure from any cause, and it can sometimes be complicated by a high incidence of thromboembolism. Prior to the availability of echocardiography, diagnosis was based only on clinical findings. Recently, inclusion of echocardiography has made diagnosis of PPCM easier and more accurate. Its etiopathogenesis is still poorly understood, but recent evidence supports inflammation, viral infection and autoimmunity as the leading causative hypotheses. Prompt recognition with institution of intensive treatment by a multidisciplinary team is a prerequisite for improved outcome. Conventional treatment consists of diuretics, ? blockers, vasodilators, and sometimes digoxin and anticoagulants, usually in combination. In resistant cases, newer therapeutic modalities such as immunomodulation, immunoglobulin and immunosuppression may be considered. Cardiac transplantation may be necessary in patients not responding to conventional and newer therapeutic strategies. The role of the anesthesiologist is important in perioperative and intensive care management. Prognosis is highly related to reversal of ventricular dysfunction. Compared to historically higher mortality rates, recent reports describe better outcome, probably because of advances in medical care. Based on current information, future pregnancy is usually not recommended in patients who fail to recover heart function. This article aims to provide a comprehensive updated review of PPCM covering etiopathogeneses, clinical presentation and diagnosis, as well as pharmacological, perioperative and intensive care management and prognosis, while stressing areas that require further research.

Pradipta Bhakta; Binay K Biswas; Basudeb Banerjee

489

Corresponding author:

  CiteSeer

Summary: ? The authors have no financial conflicts of interest. Peripartum cardiomyopathy (PPCM) is a rare entity, and anesthetic management for cesarean section of a patient with this condition can be challenging. We hereby present the anesthetic management of a patient with PPCM complicated with preeclampsia scheduled for cesarean section, along with a mini review of literature. A 24 year-old primigravida with twin gestation was admitted to our hospital with severe PPCM and preeclampsia for peripartum care, which finally required a cesarean section. Preoperative optimization was done according to the goal of managing left ventricular failure. Combined spinal epidural (CSE) anaesthesia with bupivacaine and sufentanil was used for cesarean section under optimal monitoring. The surgery was completed without event or complication. Postoperative pain relief was adequate and patient required only one epidural top up with sufentanil 6 hours after operation. To the best of our knowledge there is no report in literature of the use of sufentanil as a neuraxial opioid in the anesthetic management of cesarean section in a patient with PPCM. CSE with sufentanil may be a safer and more effective alternative in such cases.

Pradipta Bhakta; Pragnyadipta Mishra; Anamika Bakshi; Vijay Langer; Dr. Pragnyadipta Mishra
2009-01-01

490

and

  CiteSeer

Summary: Abstract: Some Asian people believe that opium can protect the cardiovascular system. To assess this belief, we investigated the effect of passive opium smoking (POS) on cardiovascular indices in rabbits with ischemic and non-ischemic hearts. Rabbits (n = 43) were divided into control (CTL), short term opium (SO) and long term opium (LO) groups. SO and LO groups were exposed to opium smoking for 3 days and 4 weeks, respectively. ECG, blood pressure (BP), left ventricular pressure and cardiac troponin I levels were recorded. Isoproterenol (ISO) was injected to induce cardiac ischemia and after 4 h the above variables were measured along with cardiac histopathology assessment. All groups showed significant increments in troponin I level (P < 0.05) except the CTL group. This trend was more obvious in ISO-treated groups. Mean arterial pressure (MAP) significantly decreased in all groups (p< 0.05) except the LO group. Opium exposure attenuated ISO-induced myodegeneration but augmented tissue congestion and hemorrhage. In conclusion, higher troponin I serum level and ECG changes were found in passive opium smoking groups. This evidence is against the belief that opium can protect the cardiovascular system.

Siyavash Joukar; Hamid Najafipour; Fatemeh Mirzaeipour; Hamid Reza Nasri

491

Changes in the Organization of Excitation-Contraction Coupling Structures in Failing Human Heart

  CiteSeer

Summary: Background: The cardiac myocyte t-tubular system ensures rapid, uniform cell activation and several experimental lines of evidence suggest changes in the t-tubular system and associated excitation-contraction coupling proteins may occur in heart failure. Methods and Results: The organization of t-tubules, L-type calcium channels (DHPRs), ryanodine receptors (RyRs) and contractile machinery were examined in fixed ventricular tissue samples from both normal and failing hearts (idiopathic (non-ischemic) dilated cardiomyopathy) using high resolution fluorescent imaging. Wheat germ agglutinin (WGA), Na-Ca exchanger, DHPR and caveolin-3 labels revealed a shift from a predominantly transverse orientation to oblique and axial directions in failing myocytes. In failure, dilation of peripheral t-tubules occurred and a change in the extent of protein glycosylation was evident. There was no change in the fractional area occupied by myofilaments (labeled with phalloidin) but there was a small reduction in the number of RyR clusters per unit area. The general relationship between DHPRs and RyR was not changed and RyR labeling overlapped with 5163 % of DHPR labeling in normal hearts. In longitudinal (but not transverse) sections there was an,30 % reduction in the degree of colocalization between DHPRs and RyRs as measured by Pearson’s correlation coefficient in failing hearts. Conclusions: The results show that extensive remodelling of the t-tubular network and associated excitation-contraction


2010-01-01

492

Modifications of the lnotropic Responses to a- and p- Adrenoceptor Stimulation by Propofol in Rat Myocardium

  CiteSeer

Summary: Propofol induces cardiovascular depression but without significant effect on intrinsic myocardial contractility in many species. However, its interactions with adrenoceptor stimulation are unknown. We studied the effects of propofol(1 and 10 &mL) and its solvent on the inotro ic response induced by phenylephrine (lO~H-lO ~ P M) or isoproterenol (10~~8-10~4 M) in rat left ventricular papillary muscles in vitro (Krebs-Henseleit solution, 29”C, pH 7.40, calcium 0.5 mM, stimulation frequency 12 pulses/min). We also studied the lusitropic effects in isotonic and isometric conditions. In control groups, phenylephrine (127 %-+ 3 % of baseline; P < 0.05) and isoproterenol (169%,-+ 11 % of baseline; P < 0.05) induced a positive inotropic effect. Propofol (10 kg/mL) completely abolished the positive inotropic effect of phenylephrine (100 % ? 3 % of baseline; P = not significant). In contrast, at the lowest concentration (1 pg/mL), propofol did not modify the positive inotropit effect of phenylephrine. Propofol did not modify the inotropic effect of isoproterenol. Propofol (10 pg/mL) enhanced the positive lusitropic effect of isoproterenol under low-load (P < 0.05) but not under high-load conditions. Implications: A high concentration of propofol abolished the positive inotropic effect of a- but not /3-adrenoceptor stimulation and enhanced the positive lusitropic effect of /3-adrenoceptor stimulation.

Bruno Riou

493

[Na] and [K] Dependence of the Na/K Pump Current-Voltage Relationship in

  CiteSeer

Summary: ABSTRACT Na/K pump current was determined between- 140 and +60 mV as steady-state, strophanthidin-sensitive, whole-cell current in guinea pig ventricular myocytes, voltage-clamped and internally dialyzed via wide-tipped pipettes. Solutions were designed to minimize all other components of membrane current. A device for exchanging the solution inside the pipette permitted investigation of Na/K pump current-voltage (I-V) relationships at several levels of pipette [Na] ([Na]m) in a single cell; the effects of changes in external [Na] ([Na]o) or external [K] ([K]o) were also studied. At 50 mM [Na]#p, 5.4 mM [K]o, and ~150 mM [Na]o, Na/K pump current was steeply voltage dependent at negative potentials but was approximately constant at positive potentials. Under those conditions, reduction of [Na]o enhanced pump current at negative potentials but had little effect at positive potentials: at zero [Na]o, pump current was only weakly voltage dependent. At 5.4 mM [K]o and ~150 mM [Na]o, reduction of [Na]~, from 50 mM scaled down the sigmoid pump I-V relationship and shifted it slightly to the right (toward more positive potentials). Pump current at 0 mV was activated by [Na]p ~ according to

Guinea Pig; Ventricular Myocytes; Masakazu Nakao; David C. Gadsby

494

Three-dimensional structure of the flow inside the left ventricle of the human heart

  CERN Preprints

Summary: The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data obtained in vivo. Nevertheless, some questions are still open and new ones stem from the continuous improvements in the diagnostic imaging techniques. Many of these unresolved issues are related to the three-dimensional structure of the left-ventricular flow during the cardiac cycle. In this paper we investigated in detail this aspect using a laboratory model. The ventricle was simulated by a flexible sack varying its volume in time according to a physiologically shaped law. Velocities measured during several cycles on series of parallel planes, taken from two orthogonal points of view, were combined together in order to reconstruct the phase averaged, three-dimensional velocity field. During the diastole, three main steps are recognized in the evolution of the vortical str...

Fortini, S; Espa, S; Cenedese, A
2014-01-01

495

THE EFFECT OF LANATOSIDE-C ON THE RESPONSE OF THE HUMAN CARDIAC OUTPUT TO WALKING EXERCISE

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Summary: When the possibility of heart failure is anticipated in the human subject during exercise, or during some other form of circulatory stress such as a surgical operation, the chance of benefit from the administration of digitalis must be weighed against the probability of circulatory impairment by the drug if no heart failure appears-a probability which has been suggested by prior clinical observations, ' and by physiological studies in resting human subjects free of heart failure." " Ue1 However, the changes of cardiac output caused by digitalis at rest may not necessarily indicate what effects the drug will have on the stressed circulation. In the normal dog, for instance, the resting systemic blood flow is reduced7 by a dose of cardiac glycoside which increases ventricular contractility, ' and which improves the output of the heart working under an increased pressure or flow load. ' It is apparent that the effect of digitalis on circulatory competence is best measured by a change of cardiac output when the heart is operating near the limit of its capacity, or when the adequacy of the output may be expressed in terms of concomitant peripheral circulatory demands. The present investigation was prompted by the need for more definitive information regarding the effect of cardiac glycosides on the normal human circulation under stress. With the aforementioned considerations in mind, it was proposed to evaluate the effect of Lanatoside-C on the circulatory response to some form of exercise commonly required of the human subject. For this purpose, it was of paramount importance to choose the proper type and degree of exercise with which to challenge the circulation, as well as the most suitable measurements by which to evaluate the circulatory response.

Allan V. N. Goodyer; Andrew Huvosf

496

Cat heart muscle in vitro. I. Cell volumes and intracellular concentration in papillary muscle

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Summary: ABSTRACT Methods have been developed for the simultaneous determination of total water, inulin space, and K and Na content in muscles of 0.5 to 10 rag. wet weight. These methods have been used to define steady state conditions with respect to intracellular K concentration in papillary muscles from cat hearts perfused and contracting isometrically at 27-28°C. and at 37-38°C. Cell volumes and intracellular ionic concentrations have been followed as a function of the external K concentration and compared with values predicted on the basis of electroneutrality and osmotic equilibrium. The papillary muscle preparation from the right ventricle of cats, introduced by Cattell and Gold (1), is particularly suitable for in vitro electrophysiological studies. Since the papillary muscle is attached to the ventricular myocardium by a narrow isthmus of muscle, it may be excised and isolated as a relatively intact tissue without extensive dissection across muscle fibers. The arrangement of its cells as histologically parallel fibers (2) renders the preparation suitable for quantitative measurements of contractile parameters (3), and permits an estimation of cell surface area needed for the expression of absolute fluxes. The small diameter of this approximately cylindrical tissue meets the geometric requirements defined by Hill (4) for oxygenation of an actively respiring muscle. Moreover, as pointed out by Keynes (5), the use of very small muscles minimizes the uncertainty in the determination of K fluxes. This uncertainty arises from the slowness of K diffusion in the extracellular space of muscle as compared to its diffusion in free solution, and is reduced


1960-01-01

497

Research Article The Effect of Metformin on the Myocardial Tolerance to Ischemia-Reperfusion Injury in the Rat Model of Diabetes Mellitus Type II

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Summary: Copyright © 2011 Ekaterina Kravchuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In recent years, evidence has been accumulated that metformin, an antidiabetic drug in the biguanide class, in addition to its well-recognized glucose-lowering effect, can also reduce cardiovascular mortality in the patients with type 2 diabetes mellitus (T2DM). Besides, there are a few experimental studies on the possibility of the direct anti-ischemic effect of the drug in both type 1 diabetes mellitus and T2DM. In our study, myocardial tolerance to ischemia in rats with neonatal streptozotocin T2DM was investigated using the model of global ischemia-reperfusion of the isolated perfused heart. Metformin was administered i.p. at a dose of 200 mg/kg/day for 3 days prior to isolated heart perfusion. The results showed that both the infarct size and postischemic recovery of left ventricular function were not different between controls and metformin-treated animals. At the same time, the infarct size in the T2DM animals was significantly lower than that in the controls (24.4 ± 7.6 % versus 45.0 ± 10.4%, resp., P<.01), indicative of the metabolic preconditioning in T2DM. It follows that the protocol of metformin administration used in this study had not elicited cardioprotective effect in animals with T2DM so that the different mechanism(s) may underlie the beneficial effect


498

Identification of a Peptide Toxin from Grammostola spatulata Spider Venom that Blocks Cation-selective Stretch-activated Channels

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Summary: abstract We have identified a 35 amino acid peptide toxin of the inhibitor cysteine knot family that blocks cationic stretch-activated ion channels. The toxin, denoted GsMTx-4, was isolated from the venom of the spider Grammostola spatulata and has ?50 % homology to other neuroactive peptides. It was isolated by fractionating whole venom using reverse phase HPLC, and then assaying fractions on stretch-activated channels (SACs) in outside-out patches from adult rat astrocytes. Although the channel gating kinetics were different between cell-attached and outside-out patches, the properties associated with the channel pore, such as selectivity for alkali cations, conductance (?45 pS at ?100 mV) and a mild rectification were unaffected by outside-out formation. GsMTx-4 produced a complete block of SACs in outside-out patches and appeared specific since it had no effect on whole-cell voltagesensitive currents. The equilibrium dissociation constant of ?630 nM was calculated from the ratio of association and dissociation rate constants. In hypotonically swollen astrocytes, GsMTx-4 produces ?40 % reduction in swelling-activated whole-cell current. Similarly, in isolated ventricular cells from a rabbit dilated cardiomyopathy model, GsMTx-4 produced a near complete block of the volume-sensitive cation-selective current, but did not affect the anion current. In the myopathic heart cells, where the swell-induced current is tonically active, GsMTx-4 also reduced the cell size. This is the first report of a peptide toxin that specifically blocks stretch-activated currents. The toxin affect on swelling-activated whole-cell currents implicates SACs in volume regulation.

Thomas M. Suchyna; Janice H. Johnson; Katherine Hamer; Joseph F. Leykam; Douglas A. Gage; Henry F. Clemo; Clive M. Baumgarten; Frederick Sachs

499

MTHFR 677 C?T Polymorphism and the Risk of Cardiac Septal Defects: A Pilot Study

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Summary: Abstract: Congenital heart defects (CHDs) are among the most common birth defects. The majority of CHDs are polygenic diseases affected by both genetic and environmental factors. Identification of the candidate genes in folate metabolism has suggested that the 677C?T polymorphism in the Methylenetetrahydrofolate reductase (MTHFR) gene may be particularly associated with the risk of CHDs. The objective of this study was to investigate the effect of MTHFR 677C?T locus polymorphism as a risk factor for cardiac septal defects (CSDs). Forty- two patients and 90 age and sex matched infants as control group were investigated. Eleven (26.2%) patients presented with isolated atrial septal defect, (ASD), 18 (42.9%) with isolated ventricular septal defect (VSD), 8(19%) with combined ASD+VSD, and 5 (11.9%) with atrioventicular canal (AV) canal. The investigation of MTHFR 677 C?T polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The resulting odds ratio (OR) for patients carrying MTHFR C677T mutation was 1.8 (95 % CI 0.86-3.84, x 2 =1.48, p = 0.11) compared to the control and the OR for MTHFR 677CT genotype for patients was 2.13 (95 % CI 0.97-4.69, x 2 =3.63, p = 0.06) attaining only marginal significance compared with TT and CC genotype in control. Patients with AV Canal showed significantly (p = 0.007) higher percentage of CT genotype (OR 1.19 95 % CI 1.0-1.4) when compared with control. Patients with combined ASD and VSD showed significantly (p =0.05) higher percentage of CT genotypes (OR 4.68 95%CI 1.03-21.31) when compared to the control. In conclusion we suggest

Omneya I Youssef; Ghada M El Sayed

500

Percutaneous Aortic Valve Implantation Retrograde From the Femoral Artery

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Summary: Background—Percutaneous aortic valve implantation by an antegrade transvenous approach has been described but is problematic. Retrograde prosthetic aortic valve implantation via the femoral artery has potential advantages. Percutaneous prosthetic aortic valve implantation via the femoral arterial approach is described and the initial experience reported. Methods and Results—The valve prosthesis is constructed from a stainless steel stent with an attached trileaflet equine pericardial valve and a fabric cuff. After routine aortic balloon valvuloplasty, a 22F or 24F sheath is advanced from the femoral artery to the aorta. A steerable, deflectable catheter facilitates manipulation of the prosthesis around the aortic arch and through the stenotic valve. Rapid ventricular pacing is used to reduce cardiac output while the delivery balloon is inflated to deploy the prosthesis within the annulus. Percutaneous aortic prosthetic valve implantation was attempted in 18 patients (aged 816 years) in whom surgical risk was deemed excessive because of comorbidities. Iliac arterial injury, seen in the first 2 patients, did not recur after improvement in screening and access site management. Implantation was successful in 14 patients. After successful implantation, the aortic valve area increased from 0.60.2 to 1.60.4 cm2. There were no intraprocedural deaths. At follow-up of 7555 days, 16 patients (89%) remained alive. Conclusions—This initial experience suggests that percutaneous transarterial aortic valve implantation is feasible in selected high-risk patients with satisfactory short-term outcomes. (Circulation. 2006;113:842-850.) Key Words: aorta stenosis catheters stents valvuloplasty Symptomatic aortic stenosis is an accepted indication forsurgery, in which valve replacement can both reduce symptoms and extend life.1 Despite this, many patients with severe aortic stenosis do not undergo surgery because of excessive risk, advanced age, or preference. Prognosis with medical management is poor,1 and percutaneous alternatives to surgery have been limited to balloon valvuloplasty with palliation that is modest and short-lived.2,3

John G. Webb; Ronald G. Carere; Md Brad; I. Munt; Christopher E. Buller; Sanjeevan Pasupati Md Samuel Lichtenstein

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