E-print Network

E-print Network

Sample search results for: auriculo ventricular congenito

 

1

Left ventricular submitral aneurysms.

  Open Access Theses and Dissertations

Summary: ??Retrospective institutional review of the pathology, aetiology classification and surgical management of left ventricular submitral aneurysms (LVSMA). These aneurysms are a well recognized but relatively… (more)

Du Toit, Henning
2007-01-01

2

Modeling Cardiac Ventricular Activation

  CiteSeer

Summary: Abstract. We describe the microscopic and macroscopic level modeling of the cardiac activation in the realistic three-dimensional ventricles of the human heart. At the microscopic level, the subthreshold behaviour of the excitable elements (cells) is governed by a reaction-diffusion equation derived from the bidomain theory, while in the suprathreshold state the elements obey cellular automata rules. Each cell is assigned a principal fiber direction according to the fiber architecture in the human heart. At the macroscopic level, the excitation of the ventricles is controlled by a model of the conduction system based on reports on the anatomy and physiology of the human heart. In the simulations, the activation was allowed to propagate from the His bundle to Purkinje-myocardial junction sites and through the ventricular myocardium. After careful evaluation of primary activation areas and balancing the activation timing between the right and the left ventricle, the final simulated activation sequence agreed with isochrones obtained from an isolated human heart. The calculated body surface potential and magnetocardiographic maps during the QRS complex correlated well with our clinical recordings on normal subjects. Furthermore, the vectorcardiogram produced by the simulated activation showed a correct pattern, although some minor discrepancies were observed in the morphology of the 12-lead electrocardiogram. Keywords: Bidomain theory, hybrid model, anisotropy, ventricles, conduction system, human

Kim Simelius A; Jukka Nenonen A; Milan Horá?ek B

3

Asymmetrical Ventricular Enlargement in Parkinson's

  Computer Technologies and Information Sciences Websites

Summary: Asymmetrical Ventricular Enlargement in Parkinson's Disease Xuemei Huang, MD, PhD,1 * Yueh Z. Lee, Chapel Hill, North Carolina, USA; 3 Department of Medicine (Neurology), Pacific Parkinson's Research, Bethesda, Maryland, USA Abstract: Parkinson's disease (PD) typically manifests with asymmetric motor

Utah, University of

4

Ventricular repolarization during cardiovascular autonomic function testing.

  Open Access Theses and Dissertations

Summary: ??The autonomic nervous system is an important modulator of ventricular repolarization and arrhythmia vulnerability. This study explored the effects of cardiovascular autonomic function tests on… (more)

Haapalahti, Petri
2008-01-01

5

Molecular genetics of arrhythmogenic right ventricular cardiomyopathy in South Africa.

  Open Access Theses and Dissertations

Summary: ??Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable disorder characterised by progressive degeneration of the right ventricular myocardium, arrhythmias and an increased risk of sudden… (more)

Blanckenberg, Janine .
2011-01-01

6

Miniaturization of a left ventricular assist device

  Texas A&M University - TxSpace

Summary: The ventricular assist device under investigation in this study is the multiple disk centrifugal pump developed by Miller [32, 33, 34]. The pump design is based on that invented by Nikola Tesla and is termed the TAMU-MDP pump, standing for the Texas A... of the National Institute of Health (NIH) as being an accurate provider of the typical flow regime and pressure profile experienced by the human heart. As the Tesla pump is intended for use as a left ventricular assist device, only the systemic vasculature has...

Milios, Gregory Scott
1996-01-01

7

Magnetic Design for the PediaFlow Ventricular Assist Device

  Engineering Websites

Summary: Magnetic Design for the PediaFlow Ventricular Assist Device *Myounggyu D. Noh, James F. Antaki describes a design process for a new pediatric ventricular assist device, the PediaFlow. The pump: Suspended pump. INTRODUCTION The unmet demand for ventricular assist devices (VADs) specifically designed

Paden, Brad

8

AV. A model for human ventricular tissue

  CiteSeer

Summary: 2003; 10.1152/ajpheart.00794.2003.—The experimental and clinical possibilities for studying cardiac arrhythmias in human ventricular myocardium are very limited. Therefore, the use of alternative methods such as computer simulations is of great importance. In this article we introduce a mathematical model of the action potential of human ventricular cells that, while including a high level of electrophysiological detail, is computationally cost-effective enough to be applied in large-scale spatial simulations for the study of reentrant arrhythmias. The model is based on recent experimental data on most of the major ionic currents: the fast sodium, L-type calcium, transient outward, rapid and slow delayed rectifier, and inward rectifier currents. The model includes a basic calcium dynamics, allowing for the realistic modeling of calcium transients, calcium current inactivation, and the contraction staircase. We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that

D. Noble; P. J. Noble; A. V. Panfilov; Panfilov A Am; J Physiol Heart

9

GENES, ASSOCIATED WITH LEFT VENTRICULAR MASS, BODY SIZE, AND BLOOD PRESSURE IN YOUNG WOMEN.

  Open Access Theses and Dissertations

Summary: ??Left ventricular hypertrophy is an independent risk factor for cardiovascular disease morbidity and mortality in adults. Left ventricular (LV) mass varies substantially among individuals, and… (more)

SMITH, KATHLEEN LOUISE
2005-01-01

10

Modification of ventricular repolarization in silent long QT syndrome mutation carriers.

  Open Access Theses and Dissertations

Summary: ??Congenital long QT syndrome (LQTS) is a familial disorder characterized by ventricular repolarization that makes carriers vulnerable to malignant ventricular tachycardia and sudden cardiac death.… (more)

Hekkala, Anna-Mari
2011-01-01

11

Powering a Ventricular Assist Device (VAD) With the

  Materials Science Websites

Summary: INVITED P A P E R Powering a Ventricular Assist Device (VAD) With the Free-Range Resonant source to an implanted cardiac device, and it proposes recharging implanted batteries using magnetically. For ventricular assist devices (VADs), wireless power technol- ogy will eliminate the complications and infections

Hochberg, Michael

12

A novel approach for the diagnosis of ventricular tachycardia based on phase space reconstruction of ECG

  CERN Preprints

Summary: Ventricular arrhythmias comprise a group of disorders which manifest clinically in a variety of ways from ventricular premature beats (VPB) and no sustained ventricular tachycardia (in healthy subjects) to sudden cardiac death due to ventricular tachyarrhythmia in patients with and/or without structural heart disease. Ventricular fibrillation (VF) and ventricular tachycardia (VT) are the most common electrical mechanisms for cardiac arrest. Accurate and automatic recognition of these arrhythmias from electrocardiography (ECG) is a crucial task for medical professionals. The purpose of this research is to develop a new index for the differential diagnosis of normal sinus rhythm (SR) and ventricular arrhythmias, based on phase space reconstruction (PSR).

Koulaouzidis, George; Cappiello, Grazia; Mazomenos, Evangelos B; Maharatna, Koushik; Morgan, John
2014-01-01

13

Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment

  Biology and Medicine Websites

Summary: Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment Liana), 127 cognitively normal Parkinson's disease (PD; PDCN) and 31 PD-associated mild cognitive impairment Inc. All rights reserved. Keywords: Parkinson disease; Mild cognitive impairment; MCI; Brain atrophy

Thompson, Paul

14

Right Ventricular Outflow Tract Reconstruction with Bicuspid Valved Polytetrafluoroethylene Conduit

  Engineering Websites

Summary: Right Ventricular Outflow Tract Reconstruction with Bicuspid Valved Polytetrafluoroethylene Conduit we have developed and utilized a bicuspid valved polytetrafluoroethylene conduit (PTFE we have developed and utilized a bicuspid valved polytetrafluoroethylene (PTFE) conduit using

Pekkan, Kerem

15

Left ventricular structure in children with developmental coordination disorder.

  Open Access Theses and Dissertations

Summary: ??Developmental coordination disorder (p-DCD) is a neuro-developmental disorder featuring impairment in developing motor coordination. This study examined left ventricular mass (LVM) in children with p-DCD… (more)

Chirico, Daniel
2011-01-01

16

Open Access Catheter Ablation of Parahisian Premature Ventricular Complex

  CiteSeer

Summary: Catheter ablation is performed in selected patients with a symptomatic premature ventricular complex (PVC) or PVC-induced cardiomyopathy. Ablation of PVC from the His region has a high risk of inducing a complete atrioventricular block. Here we report successful catheter ablation of a parahisian PVC in a 63-year-old man. (Korean Circ J 2011;41:766-769) KEY WORDS: Premature ventricular complexes; Bundle of His; Catheter ablation.

unknown authors

17

VENTRICULAR FIBRILLATION AND BLOOD CHEMISTRY FROM SINGLE AND MULTIPLE TASERX26 DISCHARGES ON PIGS

  Multidisciplinary Databases and Resources Websites

Summary: VENTRICULAR FIBRILLATION AND BLOOD CHEMISTRY FROM SINGLE AND MULTIPLE TASERX26 DISCHARGES ON PIGS)............................................................................. 17 7.2 Chapter 3 ­ Ventricular fibrillation and blood chemistry after multiple Tasering of pigs

Sheridan, Jennifer

18

The Mathematical Modelling of Inhomogeneities in Ventricular Tissue

  Nonlinear Sciences (arXiv)

Summary: Cardiac arrhythmias such as ventricular tachycardia (VT) or ventricular fibrillation (VF) are the leading cause of death in the industrialised world. There is a growing consensus that these arrhythmias arise because of the formation of spiral waves of electrical activation in cardiac tissue; unbroken spiral waves are associated with VT and broken ones with VF. Several experimental studies have been carried out to determine the effects of inhomogeneities in cardiac tissue on such arrhythmias. We give a brief overview of such experiments, and then an introduction to partial-differential-equation models for ventricular tissue. We show how different types of inhomogeneities can be included in such models, and then discuss various numerical studies, including our own, of the effects of these inhomogeneities on spiral-wave dynamics. The most remarkable qualitative conclusion of our studies is that the spiral-wave dynamics in such systems depends very sensitively on the positions of these inhomogeneities.

T. K. Shajahan; Sitabhra Sinha; Rahul Pandit
2007-03-25

19

A two phase harmonic model for left ventricular function

  CERN Preprints

Summary: A minimal model for mechanical motion of the left ventricle is proposed. The model assumes the left ventricle to be a harmonic oscillator with two distinct phases, simulating the systolic and diastolic phases, at which both the amplitude and the elastic constant of the oscillator are different. Taking into account the pressure within the left ventricle, the model shows qualitative agreement with functional parameters of the left ventricle. The model allows for a natural explanation of heart failure with preserved systolic left ventricular function, also termed diastolic heart failure. Specifically, the rise in left ventricular filling pressures following increased left-ventricular wall stiffness is attributed to a mechanism aimed at preserving heart rate and cardiac output.

Dubi, S; Dubi, Y
2006-01-01

20

Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes with Realistic Transverse Tubules

  Mathematics Websites

Summary: ForReview Only Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes with Realistic, Mathematics TIPS: calcium dynamics, ventricular myocytes, numerical simulation, finite element methods, meshless methods #12;ForReview Only 1 Multi-Scale Modeling of Calcium Dynamics in Ventricular Myocytes

Holst, Michael J.

21

Numerical analysis of Ca2+ signaling in rat ventricular

  Mathematics Websites

Summary: . Various alterations in the protein distributions or cell ultra-structure are now recognized-tubules of mammalian ventricular myocytes are invaginations of the cell membrane that occur at each Z-line. These invaginations branch within the cell to form a complex network that allows rapid propagation of the electrical

Holst, Michael J.

22

Blood damage measures for ventricular assist device modeling

  Materials Science Websites

Summary: Blood damage measures for ventricular assist device modeling Dhruv Arora1, Marek Behr1 and Matteo challenge that needs to be addressed in the design phase of blood pumps is the elevated level of shear stress, and the hemolysis response of the red blood cells, which depends on both the dose and time

Natelson, Douglas

23

Are Nonlinear Ventricular Arrhythmia Characteristics Lost, as Signal Duration Decreases?

  Engineering Websites

Summary: is proposed. The accuracy of the proposed method in identifying sinus rhythm (SR), monomorphic ventricular networks. Classification accuracies for SR, MVT, PVT and VF were 93-96, 95-100, 79-91, and 81-88%, respectively. As expected, classification accuracy for the proposed method was essentially equivalent for ECG

Povinelli, Richard J.

24

UNCORRECTEDPROOF 1 Mapping genetic influences on ventricular structure in twins

  Biology and Medicine Websites

Summary: age= ^ 24.6 ( ^ SD=1.7)); and 56 same- ^ sex 18 fraternal (dizygotic, DZ) twins (28 pairs; mean ageUNCORRECTEDPROOF 1 Mapping genetic influences on ventricular structure in twins 2 Yi-Yu Chou the lateral ventricles, in 3D volumetric MRI 17 scans of 76 identical (monozygotic, MZ) twins (38 pairs; mean

Thompson, Paul

25

Surface Registration for Ventricular Morphometry Analysis in Mild Cognitive Impairment

  Mathematics Websites

Summary: Surface Registration for Ventricular Morphometry Analysis in Mild Cognitive Impairment Jie Shi1 impairment (MCI) individuals who converted to incident AD in the subsequent 36 months, which we call the MCI Alzheimer's disease using a hypometabolic convergence index. Neuroimage 56, 52-60. space is visualized

Wang, Yalin

26

Using Blood Pressure Data to Detect Premature Ventricular Contraction Beat

  CiteSeer

Summary: Abstract — In this paper we present an algorithm to detect premature ventricular contraction beats (PVCs) which based on blood pressure measuring data technique. A PVC beat is chosen and compared with the number of heart beats per unit time (Heart rate) using Mat lab. The heart rate may be too fast or too slow. PVC beats are then detected using a decision parameter which is a discrete function of two unequal indices. One of the indices is linearly dependent on inter-beat duration time and the other is a total beat duration time of the premature ventricular contraction coefficient between blood pressure beat and the PVC beat. Potential of this proposed method was examined using Mat lab algorithm database. Results show high sensitivity of beat recognition.

G. M. A Ehsanur Rahman; Nahid Hasan; M Saddam; Hossain Khan

27

The Genetic Architecture of Echocardiographically Determined Measures of Left Ventricular Remodeling in African-Americans of the Genetic Epidimiology Network of Arteriopathy (GENOA) Study.

  Open Access Theses and Dissertations

Summary: ??Echocardiographic measures of left ventricular remodeling, including left ventricular mass (LVM) and relative wall thickness (RWT), are powerful, independent predictors of heart disease morbidity and… (more)

Meyers, Kristin Joy
2009-01-01

28

100 J. Neurosurg. / Volume 109 / July 2008 HE pathogenesis of ventricular dilation in NPH re-

  Mathematics Websites

Summary: properties of the brain parenchyma could favor or even cause ventricular di- lation at a normal pressure.12 Hakim et al.5 proposed that the brain could be considered as a porous viscoelastic material to be computed using FE analysis.13 So far, several studies have simulated ventricular dilation in 2D brain

Frey, Pascal

29

Ranking the Clinical and Pathological Correlates of Ventricular Expansion Mapped in 804 Alzheimer's

  Biology and Medicine Websites

Summary: expansion. For CSF biomarkers (Figure 2), correlations were significant between ventricular expansionRanking the Clinical and Pathological Correlates of Ventricular Expansion Mapped in 804 Alzheimer's Abstract No: 2507 Authors: YIYU CHOU 1 , Natasha Lepore 2 , Priyanka Saharan 1 , Sarah Madsen 1 , Xue Hua 1

Thompson, Paul

30

Diagnostic accuracy and variability of three semi-quantitative methods for assessing right ventricular systolic function

  Physics Websites

Summary: ventricular systolic function from cardiac MRI in patients with acquired heart disease Jérôme Caudron-quantitative (SQt) methods for assessing right ventricular (RV) systolic function from cardiac MRI in patients of training in cardiac MRI. Correlation with RVEF, intra- and inter-observer variability, and receiver

Paris-Sud XI, Université de

31

Totally tubular: the mystery behind function and origin of the brain ventricular system

  Biology and Medicine Websites

Summary: Totally tubular: the mystery behind function and origin of the brain ventricular system Laura Anne School, 240 Longwood Ave, Boston, MA, USA A unique feature of the vertebrate brain is the ventricular by neu- roepithelium. While CSF is critical for both adult brain function and embryonic brain development

Lowery, Laura Anne

32

Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function in Dogs

  Engineering Websites

Summary: of the ventricular­vascular system have been demonstrated to be sensitive to pulmonary vascular disease.16Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function) Associate Editor Ender A. Finol oversaw the review of this article. Abstract--Pulmonary hypertension (PH

Chesler, Naomi C.

33

Impact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function in Dogs

  Engineering Websites

Summary: -text$watermark-text$watermark-text #12;INTRODUCTION Pulmonary arterial hypertension (PAH) is a devastating disease exhibiting fast to pulmonary vascular disease.16 The parameter vv, which is the ratio of end systolic ventricular elastance EesImpact of Acute Pulmonary Embolization on Arterial Stiffening and Right Ventricular Function

Chesler, Naomi C.

34

Computer simulation of a novel technique for Radio-Frequency Ablation of ventricular arrhythmias

  MIT - DSpace

Summary: Ventricular Tachycardia (VT) is a rapid arrhythmia, most commonly due to reentrant electrical activity in the heart. A common treatment for VT is Radio-Frequency Ablation (RFA), which is minimally invasive, but requires ...

Rosbury, Tamara S
2006-01-01

35

A novel means of cardiac catheter guidance for ablation therapy of ventricular tachycardia

  MIT - DSpace

Summary: This work presents a system for identifying the site of origin of ventricular tachycardia (VT) and guiding a catheter to that site in order to deliver radio-frequency (RF) ablation therapy. Myocardial infarction (MI), also ...

Lv, Wener
2014-01-01

36

Three dimensional aspects of re-entry in experimental and numerical models of ventricular

  Mathematics Websites

Summary: wave on the surface of the heart a side view would show an almost planar wave train, a rear view a "V-entry waves are masked by the inhomogeneity, anisotropy and three-dimensional nature of the ventricular wall

Biktashev, Vadim N.

37

Excessiva atividade de remodelamento ventricular sinaliza limitada resposta terapêutica ao manejo agressivo da insuficiência cardíaca avanaçada.

  Open Access Theses and Dissertations

Summary: ??Introdução: Níveis de fator de necrose tumoral¿alfa (TNF-¿), N-peptídeo do pró-colágeno III (PIIINP) e metaloproteinase de matriz ¿1 (MMP-1), marcadores biológicos de remodelamento ventricular, estão… (more)

Marcello Ávila Mascarenhas
2005-01-01

38

The role of calcineurin in high-renin and low-renin animal models of pressure overload left ventricular hypertrophy.

  Open Access Theses and Dissertations

Summary: ??Left ventricular hypertrophy (LVH) in response to pressure overload is associated with increased cardiovascular morbidity and mortality, making its prevention an important therapeutic goal. The… (more)

Benson, Victoria Louise
2005-01-01

39

Marcadores prognósticos derivados da monitorização eletrocardiográfica de 24 horas (Holter) em pacientes com disfunção sistólica ventricular esquerda meta-análise.

  Open Access Theses and Dissertations

Summary: ??A disfuncao sistolica ventricular esquerda (DSVE) geralmente precede a insuficiencia cardiaca sistolica. A insuficiencia cardiaca e um importante problema de saude publica com grande impacto… (more)

Marcos Roberto de Sousa
2008-01-01

40

Immunology of allosensitization observed with left ventricular assist device implantation: can newly developed methods define precise antibody specificities?.

  Open Access Theses and Dissertations

Summary: ??Patients implanted with left ventricular assist devices (LVAD) often develop lymphocyte reactive antibodies (allosensitization) leading to prolonged waiting time and possible poor transplant outcome. The… (more)

Greer, Ryan W.
2005-01-01

41

MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY-BASED COHORT

  Biology and Medicine Websites

Summary: MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY of Radiology 7 , Neurology 8 and Psychiatry 9 , Emory University; The Robotics Institute, Carnegie Mellon ventricular expansion in Alzheimer's Disease (AD) and mild cognitive impairment (MCI) in a large cohort

Thompson, Paul

42

The cardiac renin-angiotensin system is responsible for high salt diet-induced left ventricular hypertrophy in mice

  Physics Websites

Summary: The cardiac renin-angiotensin system is responsible for high salt diet-induced left ventricular increases in collagen density, ACE activity, AT1 receptor density and extracellular signal-regulated kinase,version1-22Nov2010 #12;3 Introduction Left ventricular hypertrophy (LVH) contributes to cardiovascular

Paris-Sud XI, Université de

43

Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation

  Nonlinear Sciences (arXiv)

Summary: Ventricular fibrillation, the major reason behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart makes it incapable of any concerted pumping action. Methods of controlling ventricular fibrillation include electrical defibrillation as well as injected medication. Electrical defibrillation, though widely used, involves subjecting the whole heart to massive, and often counterproductive, electrical shocks. We propose a defibrillation method that uses a very-low-amplitude shock (of order mV) applied for a brief duration (of order 100 ms) and over a coarse mesh of lines on our model ventricle.

Sitabhra Sinha; Ashwin Pande; Rahul Pandit
2001-04-04

44

Vocal fold and ventricular fold vibration in period-doubling phonation: Physiological description and aerodynamic

  Computer Technologies and Information Sciences Websites

Summary: glottal images obtained by high-speed cinematography. The periodic variation in glottal cycle duration; Sakakibara et al., 2001, 2004 , Mediterranean tradi- tional polyphony Henrich et al., 2006 , rock singing . In this phonatory gesture, the ventricular fold vibra- tory movement is periodic, occurring every two glottal cycles

Boyer, Edmond

45

Design and Transient Computational Fluid Dynamics Study of a Continuous Axial Flow Ventricular Assist Device

  Environmental Sciences and Ecology Websites

Summary: Assist Device XINWEI SONG,* ALEXANDRINA UNTAROIU,* HOUSTON G. WOOD,* PAUL E. ALLAIRE,* AMY L. THROCKMORTON, STEVEN W. DAY,* AND DONALD B. OLSEN A ventricular assist device (VAD), which is a miniaturized- ular assist devices (VAD) that merely assist the native ventricle to pump blood through the body and

Day, Steven

46

MODELS OF VENTRICULAR FIBRILLATION PROBABILITY AND NEUROMUSCULAR STIMULATION AFTER TASER USE IN HUMANS

  Multidisciplinary Databases and Resources Websites

Summary: IN HUMANS by Hongyu Sun A dissertation submitted in partial fulfillment of the requirements for the degree.............................................................................................................................9 CHAPTER 2 Creating a finite-element model that estimates current density in the human torso......................................................................................................................................61 CHAPTER 4 Estimating the probability that the Taser® directly causes human ventricular

Sheridan, Jennifer

47

Pediatric Mechanical Circulatory Support Thermal Analysis of the PediaFlow Pediatric Ventricular

  Engineering Websites

Summary: devices is crucial in avoiding tissue and blood thermotrauma. Ther- mal models of new Maglev ventricular- vection into blood passing through the pump and conduction through surrounding tissue. Coefficients and blood contacting surfaces are estimated based on maximum temperature rise at respective sur- faces

Paden, Brad

48

Hippocampal, Caudate, and Ventricular Changes in Parkinson's Disease with and Without Dementia

  Biology and Medicine Websites

Summary: Hippocampal, Caudate, and Ventricular Changes in Parkinson's Disease with and Without Dementia: Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini- Mental State

Thompson, Paul

49

ARTICLE IN PRESS 3D mapping of ventricular and corpus callosum abnormalities in

  Biology and Medicine Websites

Summary: computational anatomy techniques, we mapped how AIDS impacts the corpus callosum (CC) and ventricular system, two systems that show prominent changes on MRI. We (1) identified regions with greatest differences differences with measures of immune system deterioration and cognitive decline. Methods: 51 3D brain MRI scans

Thompson, Paul

50

Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models

  Biology and Medicine Websites

Summary: high correlation with strains simultaneously obtained from invasive measurements using implanted ventricular myocardium along its fiber directions. The measurements and the model are integrated within, in turn, used to calculate the deformation of the heart wall in terms of the strains. This method

Duncan, James S.

51

Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models.

  Biology and Medicine Websites

Summary: high correlation with strains simultaneously obtained from invasive measurements using implanted ventricular myocardium along its fiber directions. The measurements and the model are integrated within, in turn, used to calculate the deformation of the heart wall in terms of the strains. This method

Duncan, James S.

52

Three dimensional aspects of reentry in experimental and numerical models of ventricular

  Mathematics Websites

Summary: wave on the surface of the heart; a side view would show an almost planar wave train, a rear view a ''V­entry waves are masked by the inhomogeneity, anisotropy and three­dimensional nature of the ventricular wall

Biktashev, Vadim N.

53

Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat Ventricular Cardiac Myocytes*

  Biology and Medicine Websites

Summary: Adrenomedullin Gene Expression Is Developmentally Regulated and Induced by Hypoxia in Rat regulatory se- quence that mediates the hypoxia-inducible transcrip- tional response is located at ­1095. These data demonstrate that the adrenomedullin gene is develop- mentally regulated in ventricular

Wojcik, Edward J.

54

Methods for Measuring Right Ventricular Function and Hemodynamic Coupling with the Pulmonary Vasculature

  Biology and Medicine Websites

Summary: with chronic cardio- pulmonary disease, life expectancy and quality of life could be dramatically improvedMethods for Measuring Right Ventricular Function and Hemodynamic Coupling with the Pulmonary hemodynamic cou- pling with the compliant pulmonary circulation. The RV and pulmonary circulation exhibit

Chesler, Naomi C.

55

Ventricular structures must be understood during surgical restoration for heart failure

  University of California eScholarship Repository

Summary: heart failure that could change the future of cardiac surgery.Surgery 96: 164–176, 2007 Ventricular structures must be understood during surgical restoration for heartsurgery is that alteration of structure improves function, and this concept is fundamental during surgical restoration of dilated hearts

Buckberg, G D
2007-01-01

56

Validation of a novel catheter guiding method for the ablative therapy of ventricular tachycardia in a phantom model

  MIT - DSpace

Summary: Accurate guidance of an ablation catheter is critical in the RF ablation (RFA) of ventricular tachycardia (VT). With current technologies, it is challenging to rapidly and accurately localize the site of origin of an ...

Hirschman, Gordon B.

57

Spiral Turbulence: From the Oxidation of CO on Pt(110) to Ventricular Fibrillation

  Nonlinear Sciences (arXiv)

Summary: We give a brief overview of systems that show spiral patterns and spatiotemporally chaotic states. We concentrate on two physical systems: (1) the oxidation of CO on Pt(110) and (2) ventricular fibrillation in hearts. The equations that have been suggested as simple models for these two different systems are closely related for they are both {\\it excitable media}. We present these equations and give a short summary of the phenomena they yield.}

Ashwin Pande; Sitabhra Sinha; Rahul Pandit
2000-01-27

58

Open Access Deglutition Syncope Associated With Ventricular Asystole in a Patient With Permanent Atrial Fibrillation

  CiteSeer

Summary: Deglutition syncope is a situational syncope that is diagnosed only by a detailed history. We report deglutition syncope in a 62-year-old man, who had permanent atrial fibrillation. The patient had no structural or functional abnormalities of the esophagus. During syncopal attacks, his electrocardiography showed ventricular asystole that was sustained for 12 seconds. The patient was successfully treated by implantation of a permanent pacemaker. (Korean Circ J 2010;40:99-101) KEY WORDS: Syncope; Deglutition; Atrial fibrillation.

unknown authors

59

Echocardiographic and scintigraphic methods of left ventricular ejection fraction determination in dogs: a comparative study

  Texas A&M University - TxSpace

Summary: to acquire sufficient data. The same applies to dogs with rapid respiratory rates because excessive motion of the thorax results in movement of both the heart and the transducer head. The effects of tranquilization on the LVEF of dogs is uncertain... parameter in cardiology because it is an indicator of myocardial contractility and left ventricular function. Until recently the only methods available for determining the LVEF were invasive, requiring catheterization of the heart. A rapid injection of a...

Steyn, Phillip Franswa
2012-06-07

60

An EM Strategy for Ventricular Wall Motion Analysis HuaFeng Liu, LungNgong Wong, and PengCheng Shi

  Biology and Medicine Websites

Summary: , the two main bodies of research are the frame-to-frame estimation (i.e. mechanics based kinematicsAn EM Strategy for Ventricular Wall Motion Analysis HuaFeng Liu, LungNgong Wong, and PengCheng Shi framework for left ventricular deformation analysis based upon expectation maximization (EM) principles

Shi, Pengcheng

61

An Automated 4D Approach for Left Ventricular Assessment in Clinical Cine MR Images

  CiteSeer

Summary: Abstract: Cine Magnetic Resonance (MR) imaging has become the method-of-choice for the examination of the dynamic behaviour of the heart. An assessment of the left ventriclecan reveal regions of myocardial dysfunction and their severeness. The scope of this work is acomplete analysis of the left ventricular dynamics for the usage in a clinical environment. For that purpose, endocardial and epicardial borders are automatically extracted in 3D cine data in afirst step. This is followed byasegmentation of the endocardium and the myocardium into 17 segments following the recommendations of the American Heart Association and the computation of common global volumetric values (stroke volume, ejection fraction etc.) and parameters that describe the left ventricular dynamics (wall motion, wall thickening). Aretrospective analysis ofcardiac cine MR image data from 20 patients (healthy ones, patients with abnormal wall motion, and patients who suffered an infarction)has been done. That image data has been acquired in the clinical routine at two different hospitals. The here presented automated approach led to asuccessful segmentation and assessment of the left ventricle for all data sets. The pathological cases could be identified easily due to their characteristic change of the motion pattern. The main advantage of our approach is the reproducibility of the assessment results and the gain in time for the cardiologist who has to analyse the huge amount ofcine data.

Stefan Wesarg; Stefanie Nowak

62

Hepatic and Renal Failure after Anterior Myocardial Infarction Induced Apical Ventricular Septal Defect

  CiteSeer

Summary: Copyright © 2010 Dirk Lossnitzer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We report the case of a 68-year-old man suffering from incremental hepatic and renal failure one month after anterior myocardial infarction. Cardiac MRI showed a pronounced apical post-AMI aneurysm, a moderate to severe mitral and tricuspid regurgitation as well as a hemodynamically highly significant 12 mm apical ventricular septal defect with a left-to-right ventricular shunt of almost 63 % as the underlying cause. Heart X-ray revealed a severe LAD in-stent restenosis. CAPD catheter drainage of hydroperitoneum due to congestive liver and renal failure was provided in combination with intensified CAPD hemodialysis. Heart surgery was performed where the apical aneurysm was excised, the mitral valve was reconstructed, the IVSD was closed and the subtotally in-stent occluded LAD was bypassed. Post-surgery, the ascites were significantly reduced, and CAPD hemodialysis therapy could be terminated since the renal function gradually improved (MDRD = 25 mL/min). To our knowledge, for the first time we report successful CAPD catheter drainage of hydroperitoneum in combination with CAPD hemodialysis. 1. Case Report A 68-year-old man who lived in Venezuela for the last four decades presented to our clinic with inexplicably incremental

Article Id; Dirk Lossnitzer; Vedat Schwenger; Stephanie Lehrke; Evangelos Giannitsis; Martin Zeier; Hugo A. Katus; Henning Steen

63

Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy A Practical Guide for Physicians

  CiteSeer

Summary: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetically transmitted disease. However, the genetics are more complex than in other inherited conditions wherein a single gene abnormal mutation may be causative. In ARVC, 5 causative desmosomal genes have been identified, but because only 30 % to 50 % of patients with ARVC have 1 of these gene abnormalities, it is assumed that there are other genes not yet identified. Frequently, patients with ARVC have ?1 genetic defect in the same gene (compound heterozygosity) or in a second complementary gene (digenic heterozygosity). In addition, a family member may have an ARVC gene defect and have development of the disease or have no or minimal manifestations of the disease. Clinical genetic testing is commercially available. It is beneficial for first-degree family members of a person with ARVC to have genetic testing but only if there is a known genetic abnormality in the affected person. If the affected family member (proband) with ARVC does not have a genetic defect identified, then it will not be identified in the family member. Genetic counseling is strongly advised for family members of the proband. (J Am Coll Cardiol 2013; 61:1945–8) © 2013 by the American College of Cardiology Foundation Arrhythmogenic right ventricular cardiomyopathy (ARVC) is caused by abnormalities in heart cells that connect to each other through cell-cell contacts known as the intercalated

Frank I. Marcus; Sue Edson; Jeffrey A. Towbin

64

DOI 10.1007/s12170-010-0128-2 Genetic Basis of Ventricular Arrhythmias

  CiteSeer

Summary: # The Author(s) 2010. This article is published with open access at Springerlink.com Abstract Sudden cardiac death (SCD) is a leading cause of total and cardiovascular mortality, and ventricular fibrillation is the underlying arrhythmia in the majority of cases. In the young, where the incidence of SCD is low, a great proportion of SCDs occur in the context of inherited disorders such as cardiomyopathy or primary electrical disease, where a monogenic hereditary component is a strong determinant of risk. Marked advancement has been made over the past 15 years in the understanding of the genetic basis of the primary electrical disorders, and this has had an enormous impact on the management of these patients. At older ages, the great majority of SCDs occur in the context of acute myocardial ischemia and infarction. Although epidemiologic studies have shown that heritable factors also determine risk in these cases, inheritance is likely complex and multifactorial, and progress in understanding the genetic and molecular mechanisms that determine susceptibility to these arrhythmias, affecting a greater proportion of the population, has been very limited. We review the most recent insights gained into the genetic basis of both the monogenic and the more complex ventricular arrhythmias.

Raha Pazoki; Arthur A. M. Wilde; Connie R. Bezzina; R. Pazoki; C. R. Bezzina
2010-01-01

65

Prognostic Significance and Normal Values of 2D Strain to Assess Right Ventricular Systolic Function in Chronic Heart Failure

  Physics Websites

Summary: Function in Chronic Heart Failure Short Title: RV dysfunction and prognosis in CHF Soulef Guendouz, MD1 Journal 2012;76(1):127-36" #12;2 ABSTRACT Aims: Chronic heart failure (CHF) has a poor prognosis. Our aims or emergent transplantation or emergent ventricular assist-device implantation or acute heart failure. RV-2D

Paris-Sud XI, Université de

66

Phase statistics approach to human ventricular fibrillation Ming-Chya Wu,1,2,3,* Eiichi Watanabe,4,

  Physics Websites

Summary: Phase statistics approach to human ventricular fibrillation Ming-Chya Wu,1,2,3,* Eiichi Watanabe,4 statistics of human ECG data may be a key to understanding the mechanism of spontaneous defibrillation the recently proposed empirical mode decomposition EMD 16 based approach 17­20 addresses phase properties


67

Quantitative analysis of cardiac motion is of great clinical interest in assessing ventricular function. Real-time 3-D

  Biology and Medicine Websites

Summary: ventricular function. Real-time 3-D (RT3D) ultrasound transducers provide valuable three- dimensional in RT3D ultrasound. A myocardial displacement field and dynamic cardiac metrics were computed, but is still limited to two- dimensions in most hospitals and clinical centers. Development of 3D


68

MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY-BASED COHORT

  Computer Technologies and Information Sciences Websites

Summary: MAPPING VENTRICULAR CHANGES RELATED TO DEMENTIA AND MILD COGNITIVE IMPAIRMENT IN A LARGE COMMUNITY of the cerebral ventricles with risk for and progression of dementia and MCI in elderly subjects [1] [3] [5 been proposed as a possible biomarker for estimating dementia risk or response to treatments. However


69

Atrial Near-Field and Ventricular Far-Field Analysis by Automated Signal Processing at Rest and During Exercise

  Computer Technologies and Information Sciences Websites

Summary: is a prerequisite for modern pacemaker therapy. Ideally, near-fields and ventricular far-fields ought atrial electrograms of 23 patients at least 3 months after implantation of a dual chamber pacemaker under of posture. This is a prerequisite for the implementation of beat-to-beat template analysis into pacemakers

Lübeck, Universität zu

70

Development and construction of an active mock circulation loop (MCL) for the evaluation of ventricular assist devices (VAD)

  Energy Storage, Conversion and Utilization Websites

Summary: circulatory system for evaluation of ventricular assist devices. Methods Based on the requirements defined of the circulatory model is the simulation of the residual activity of the human heart, considering the Frank of a human cardiovascular system have been developed. In summary, the preconditions for implementation

Berlin,Technische Universität

71

Abstract--We have recently introduced an algorithm for semi-automatic segmentation of the left ventricular wall in

  Biology and Medicine Websites

Summary: , the algorithm uses temporal averaging for image denoising. Motion estimation is used to detect and reject frames ventricular wall in short-axis echocardiographic images (EMBC 30:218­221). In its preprocessing stage that do not correlate well with the set of images being averaged. However, the process of estimating

Carvalho, João Luiz

72

doi:10.4061/2011/495349 Review Article Left Ventricular Hypertrophy: Major Risk Factor in Patients with Hypertension: Update and Practical Clinical Applications

  CiteSeer

Summary: Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Left ventricular hypertrophy is a maladaptive response to chronic pressure overload and an important risk factor for atrial fibrillation, diastolic heart failure, systolic heart failure, and sudden death in patients with hypertension. Since not all patients with hypertension develop left ventricular hypertrophy, there are clinical findings that should be kept in mind that may alert the physician to the presence of left ventricular hypertrophy so a more definitive evaluation can be performed using an echocardiogram or cardiovascular magnetic resonance. Controlling arterial pressure, sodium restriction, and weight loss independently facilitate the regression of left ventricular hypertrophy. Choice of antihypertensive agents may be important when treating a patient with hypertensive left ventricular hypertrophy. Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers followed by calcium channel antagonists most rapidly facilitate the regression of left ventricular hypertrophy. With the regression of left ventricular hypertrophy, diastolic function and coronary flow reserve usually improve, and cardiovascular risk decreases. 1.

Richard E. Katholi; Daniel M. Couri

73

A magnetic suspension theory and its application to the HeartQuest ventricular assist device. Artif Organs 2002;26:947–51

  CiteSeer

Summary: Abstract: Motivated by the design of the HeartQuest magnetically levitated left ventricular assist device, closed form expressions have been developed to compute forces and stiffnesses of magnetic suspensions. The theory applies to any combination of concentric permanent magnet rings, and its accuracy and versatility were verified by experiments. The equations adapt to spreadsheet implementation and numerical optimization, providing a powerful tool of optimal design of magnetically levitated ventricular assist devices (VADs). The method was applied to the development of the HeartQuest VAD which achieved remarkable compactness and stable operation. Key Words: Magnetic suspension—Design—Optimization— Blood pump—Ventricular assist device.

Chen Chen; Brad Paden; James Antaki; Jed Ludlow; Dave Paden

74

Mapping genetic influences on ventricular structure in twins Yi-Yu Chou, Natasha Lepore, Ming-Chang Chiang, Christina Avedis-

  Biology and Medicine Websites

Summary: INFLUENCES ON VENTRICULAR STRUCTURE IN TWINS Yi-Yu Chou MS1 , Natasha Leporé PhD1 , Ming-Chang Chiang MD PhD1 , Christina Avedissian1 , Marina Barysheva1 , Katie McMahon PhD2 , Greig de Zubicaray PhD2 , Matthew Meredith PhD2 , Margaret Wright PhD3 , Arthur W. Toga PhD1 , Paul M. Thompson PhD1 1 Laboratory of Neuro

Thompson, Paul

75

Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive Impairment using Multi-Atlas Fluid Image Alignment

  Biology and Medicine Websites

Summary: Mapping Ventricular Expansion and its Clinical Correlates in Alzheimer's Disease and Mild Cognitive. Thompson1 , and the Alzheimer's Disease Neuroimaging Initiative 1 Laboratory of Neuro Imaging, UCLA quantitative marker of Alzheimer's disease (AD) progression for MRI studies. In the ADNI image database, we

Thompson, Paul

76

Multidimensional ICA for the Separation of Atrial and Ventricular Activities from Single Lead ECGs in Paroxysmal Atrial Fibrillation

  CiteSeer

Summary: Abstract. The analysis of paroxysmal atrial fibrillation requires the previous estimation of the atrial activity (AA) from one lead ECG. Considering the statistical properties of the cardiac electrical activities, it follows that both AA and ventricular activity (VA) present a high redundancy degree at different time intervals, whereas AA keeps independent from VA. This contribution adopts a multidimensional independent component analysis (MICA) formulation in order to find a set of components that minimises the mutual information existing in the ECG signal at different intervals. The independent components can be grouped in VA and AA subspaces, what enables the reconstruction of the AA at each observation point from the AA subspace. The proposed approach is validated with a significant database composed of simulated and real AF recordings. 1

Francisco Castells; Cibeles Mora; José Millet; José Joaquín Rieta; César Sánchez; Juan Manuel Sanchis

77

Anomaly of the Left Anterior Descending Coronary Artery Arising from the Right Sinus of Valsalva and Ventricular Septal Defect in Adult: A Rare Case

  CiteSeer

Summary: Anomaly of the left anterior descending (LAD) coronary artery arising from the right sinus of valsalva is frequently seen with tetralogy of Fallot (TOF). The association of the LAD coronary artery with ventricular septal defect (VSD) is uncommon. We described an anomalous origin of the LAD coronary artery from the right sinus of valsalva with ventricular septal defect in a 38-year-old male patient suffering from atypical angina. The LAD coronary artery arose from the right sinus of valsalva, just next to the right coronary artery. There was a single opening in the membranous part of the interventricular septum. From this case, we suggest that angiography is useful for both documenting anomalies of the LAD coronary artery associated with VSD and for determining the safest surgical procedures.

Orhan Tacar; Aziz Karadede

78

Autism syndromes in three behavioural phenotype conditions. A clinical psychiatric study of 76 individuals with Möbius sequence, CHARGE syndrome, and oculo-auriculo-vertebral spectrum.

  Open Access Theses and Dissertations

Summary: ??AUTISM SYNDROMES IN THREE BEHAVIOURAL PHENOTYPE CONDITIONS A clinical psychiatric study of 76 individuals with Möbius sequence, CHARGE syndrome, and oculoauriculovertebral spectrum Maria Johansson Institute… (more)

Johansson, Maria
2007-01-01

79

Resonance, Ultrasound, and X-Ray CT images. Estimation of 3D Left Ventricular Deformation from Medical Images Using Biomechanical Models

  CiteSeer

Summary: The non-invasive quantitative estimation of regional cardiac deformation has important clinical implications for the assessment of viability in the heart wall. In this work we describe a general framework for estimating soft tissue deformation from sequences of three-dimensional medical images. We also explore some of their theoretical constraints which can be used to guide the selection of an appropriate model for the displacement field. We then apply this framework to the problem of estimating left ventricular deformations from sequences of 3D image sequences. The images are segmented interactively to extract the endocardial and epicardial surfaces. Then, initial frame-to-frame correspondences are established between points on the surfaces using a shape-tracking approach. The myocardium is modeled using a transversely isotropic linear elastic model, which accounts for the preferential stiffness of the left ventricular myocardium along its fiber directions. The measurements and the model are integrated within a Bayesian estimation framework. The resulting equations are solved using the finite element method, to produce a dense displacement field for the whole of the left ventricle. The dense displacement field is, in turn, used to calculate the deformation of the heart wall in terms of the strains.

Xenophon Papademetris
2000-01-01

80

The effect of temperature and adrenaline on the relative importance of the sarcoplasmic reticulum in contributing Ca 2+ to force development in isolated ventricular trabeculae from rainbow trout

  CiteSeer

Summary: The sarcoplasmic reticulum (SR) is central to intracellular Ca 2+ regulation during excitation–contraction (E-C) coupling in mammalian cardiac tissue. The importance of the SR to E-C coupling in lower vertebrates is less certain. This uncertainty can be attributed, in part, to the temperature-dependency of the SR Ca 2+-release channel and to interspecific differences in the ryanodinesensitivity of ectotherm cardiac muscle. Furthermore, the relative importance of the SR in contributing intracellular Ca 2+ to force development may be influenced by adrenergic stimulation, which increases trans-sarcolemmal (extracellular) Ca 2+ influx. The objective of this study was to assess the relative importance of SR (intracellular) and sarcolemmal (SL; extracellular) Ca 2+ fluxes during the isometric contraction of isolated ventricular trabeculae

H. A. Shiels; A. P. Farrell
1997-01-01

81

doi:10.1155/2011/497690 Clinical Study Improved Left Ventricular Diastolic Function with Exercise Training in Hypertension: A Doppler Imaging Study

  CiteSeer

Summary: which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To study the effects of 6 months ’ exercise training on ventricular function in hypertensive patients. Methods. Both groups received routine anti-hypertensive pharmacological therapy and one received a 6 months ’ exercise program in addition. All patients underwent incremental cardiopulmonary exercise test and echocardiography in baseline and after 6 months. Results. (1) In 6 months ’ follow-up, PeakVO2, Powermax (max workload), AT (anaerobic threshold), VO2AT (VO2 at anaerobic threshold), tAT (time from beginning to anaerobic threshold) (P <.05), were increased in the exercise group. HRrest (Heart rate at rest) was decreased (P <.05). LAVI (left atrial volume index), peak mitral filling velocities during early (E) and late (A) diastole E/A ratio, DT(deceleration time of the mitral E wave), IVST(Interventricular septum thickness in diastole), tissue Doppler indice Mean Ea/Aa ratio (P <.05) were also improved. (2) Correlation analysis: 4 variates had significant effect on change of PeakVO2 in the exercise group: age (r =?0.39), change of HRrest (r = 0.59), change of E/A (r = 0.55), change of Mean Ea/Aa (r = 0.58); Through analyzing 2 groups patients ’ baseline values, their age (? = ?0.32), VO2AT (? = 0.29), HRrest (? = ?0.25), LAVI (? = ?0.24), E/A (? = 0.41) were found to be independent predictors of MeanEa/Aa. P-value under.05 was considered statistically significant. Conclusion. 6 months ’ exercise could enhance hypertensive patients ’ aerobic exercise level and diastolic function to a certain extent. 1.

Huan Zheng; Ming Luo; Yi Shen; Hong Fang

82

UNCORRECTEDPROOF 1 Mapping correlations between ventricular expansion

  Biology and Medicine Websites

Summary: biomarkers in 240 subjects with Alzheimer's disease ^ , ^ mild cognitive impairment 3 and elderly controls 4. Toga a , Paul M. Thompson a, 6 The Alzheimer's Disease Neuroimaging Initiative 7 a Laboratory of Neuro reveals genetic effects ^ in Alzheimer's ^ disease, NeuroImage 40(2): 615­ ^ 630.); with this method, we

Thompson, Paul

83

What can nonlinear dynamics teach us about the development of ventricular tachycardia/ventricular

  Physics Websites

Summary: alternans, predisposes the propagating wave to breakup during the short APDs. Models based solely on simple mani- festations of reentry, that is, a self-sustaining pattern of action potential waves that reenter the rotating wave associated with VT break up into more complicated, reentrant patterns because the wave runs

Otani, Niels F.

84

The Visualization and Measurement of Left Ventricular Deformation

  Computer Technologies and Information Sciences Websites

Summary: @cs.auckland.ac.nz Abstract While medical progress has been made in the diagnosis and treatment of heart diseases it remains and the prognosis after heart failure is poor. An im- proved understanding of cardiac mechanics might advance the diagnosis and treatment of heart diseases. We have developed a toolkit designed for visualizing biomedical

Goodman, James R.

85

Anisotropic Stretch-Induced Hypertrophy in Neonatal Ventricular Myocytes

  Biotechnology Websites

Summary: , and because mechanical strains in vivo are multiaxial and anisotropic, we developed an in vitro system on deformable sili- cone membranes have been used as an in vitro model for mechanical stretch-induced cardiac-shaped and aligned in vivo. Mechanical strains in vivo are multiaxial and aniso- tropic, but previous in vitro

Bhatia, Sangeeta

86

RESEARCH ARTICLE Open Access Reduced CSF turnover and decreased ventricular

  Physics Websites

Summary: subjects had idiopathic normal pressure hydrocephalus (iNPH), and the other 22 chronic hydrocephalus from CSF turnover are known, such as idiopathic Nor- mal Pressure Hydrocephalus (iNPH), and those follow patients with decreased CSF turnover were studied. These patients presented chronic hydrocephalus

Paris-Sud XI, Université de

87

Mechanisms of slow conductions during ventricular volume loading

  University of California eScholarship Repository

Summary: Velocity In One Dimension: ?t(X) is the conduction time measured over interelectrode distancevelocity is de?ned as the distance an activation wavefront travels per unit time (though ‘distance’velocity is calculated as the distance traveled normal to the isochrones per unit time.

Mills, Robert W.
2006-01-01

88

Can Tasers directly cause ventricular fibrillation? J G Webster1

  Multidisciplinary Databases and Resources Websites

Summary: the heart to stop pumping, the blood pressure to decrease near zero, and the subject to faint almost healthy pigs ranged from 53.8 to 74.4 kg. The pigs were anesthetized and intubated. The blood pressure

Sheridan, Jennifer

89

Characterization of PHLPP1 in adult mouse ventricular myocytes

  University of California eScholarship Repository

Summary: of studying signal transduction pathways involved in cardiacsignal transduction pathways differentiating adaptive from maladaptive cardiaccardiac hypertrophy is controversial. Importance of Akt Signaling Understanding the fundamentals of signal

Huang, Katherine
2009-01-01

90

Mechanisms of slow conductions during ventricular volume loading

  University of California eScholarship Repository

Summary: refractory period, however, ERP follows action potentialaction potential duration shortening, [18] and consequently could in?uence e?ective refractory period.action potential. I.B.2 E?ects of Stretch on E?ective Refractory Period

Mills, Robert W.
2006-01-01

91

Estimation of 3D Left Ventricular Deformation from Echocardiography

  Biology and Medicine Websites

Summary: the regional function of the left ventricle (LV) of the 1 Departments of Electrical Engineering, Yale, radionuclide imaging, cine computed tomography (CT), and mag- netic resonance (MR) imaging. There have been be assessed in three-dimensional space us- ing ECG-gated single photon emission computed tomography (SPECT) [1

Duncan, James S.

92

Focused Cardiac Ultrasound for the Detection of a Ventricular Aneurysm

  University of California eScholarship Repository

Summary: significant for costophrenic angle blunting and hilar prominence bilaterally (Figuresignificant for ST segment elevation in leads V1 through V4 consistent with an anteroseptal infarct, age undetermined (Figure

Bailey, Steven; Herring, Andrew; Stone, Michael; Nagdev, Arun
2012-01-01

93

CARDIOMYOPATHY Exercise-Induced Left Ventricular Systolic Dysfunction

  Biology and Medicine Websites

Summary: : Cardiomyopathy, Women, Exercise, Heart failure, Echocardiography In men, mutations in the X-linked gene encoding to enteroviral myocarditis,3 congenital heart disease,4 and end-stage ischemic congestive heart failure.5 Women heterozygous for a disease-associated dystrophin allele are also susceptible to the development of heart

Campbell, Kevin P.

94

Focused Cardiac Ultrasound for the Detection of a Ventricular Aneurysm

  University of California eScholarship Repository

Summary: Hospital, Oakland, California Supervising Section Editor: Rick McPheeters, DO Submission history:history and focused cardiac ultrasound results, and instead was treated with optimal medical therapy. During the hospital

Bailey, Steven; Herring, Andrew; Stone, Michael; Nagdev, Arun
2012-01-01

95

Research Report Corpus callosum morphology and ventricular size in

  Mathematics Websites

Summary: and the potential impact of those changes on cognitive functions. © 2006 Elsevier B.V. All rights reserved. Keywords changes to that structure and to examine their possible effects on cognitive function. The callosal relationships between changes in callosal morphology and cognitive function. These novel findings reveal

Nguyen, Danh

96

ORIGINAL RESEARCH Progressive right ventricular functional and structural

  Engineering Websites

Summary: of pulmonary arterial hypertension Zhijie Wang1 , David A. Schreier1 , Timothy A. Hacker2 & Naomi C. Chesler1.184 Abstract Right ventricle (RV) dysfunction occurs with progression of pulmonary arterial hypertension (PAH and decreases in the efficiency of RV interactions with the pulmonary vasculature. To test this hypothesis, we

Chesler, Naomi C.

97

Design and construction of a left ventricular cardiovascular assist device

  Texas A&M University - TxSpace

Summary: Congestive heart failure (CHF) is a debilitating condition that afflicts 4.8 million Americans with an increasing incidence. Each year, there are an estimated 400,000 new cases. The incidence is on the rise as the age of the population is increasing...

Vedi, Manmeet Singh
2004-11-15

98

Numerical Analysis of Ca2+ Signaling in Rat Ventricular

  Mathematics Websites

Summary: of Bioengineering, University of California San Diego, La Jolla, California, United States of America, 2 Department of Computer Science, University of Wisconsin, Milwaukee, Wisconsin, United States of America, 3 Department of Medicine, University of California San Diego, La Jolla, California, United States of America, 4 Department

Holst, Michael J.

99

Automated Segmentation of Cerebral Ventricular Compartments Warfield SK, 1

  Computer Technologies and Information Sciences Websites

Summary: Cuttmann CRG. 1 Center for Neurological Imaging, Harvard Medical School and Brigham and Women's Hospital://www.spl.harvard.edu Harvard Medical School and Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115 USA, Synopsis the lateral, third and fourth ventricles, as well as the aqueduct is presented and validated. A novel topology

Pohl, Kilian M.

100

Hemodynamic Improvement in Cardiac Resynchronization Does Not Require Improvement in Left Ventricular

  Physics Websites

Summary: and pacing-induced heart failure (n 7), we studied the effects of CRT on LV rotation mechanics in vivo by 3 bundle branch block with pacing-induced heart failure or CRT, but there was significant apex in the mechanically dyssynchronous heart. These results suggest that LV rotation mechanics is an index of global LV

Paris-Sud XI, Université de

101

Finding Hidden Patterns in Complex Ventricular Ectopy V Schulte-Frohlinde

  Environmental Management and Restoration Websites

Summary: risk. Frequent PVCs are, for example, found in subjects with congestive heart failure. In the RR of 200 subjects with congestive heart failure. Out of these we have initially selected those subjects heart failure (subject 2 in the following figures). The upper panel shows 8000 beats, the lower panel

Ashkenazy, Yossi "Yosef"

102

Computational Fluid Dynamics Modeling of Impeller Designs for the HeartQuest Left Ventricular Assist Device

  Environmental Sciences and Ecology Websites

Summary: Assist Device ANTHONY R. CURTAS,* HOUSTON G. WOOD,* PAUL E. ALLAIRE,* JAMES C. MCDANIEL,* STEVEN W. DAY device, a suitable impeller had to be designed and tested. The new prototype was based on calculations from a total heart transplant or a mechanical assist device. Because of shortages of donor hearts

Day, Steven

103

Normal and Hydrocephalic Brain Dynamics: The Role of Reduced Cerebrospinal Fluid Reabsorption in Ventricular Enlargement

  Biology and Medicine Websites

Summary: with communicating hydrocephalus. Mathematical brain models were created using the MRI images of normal subjects­structure interaction, Communicating hydrocephalus, Intracranial pressure. INTRODUCTION A more complete understandingNormal and Hydrocephalic Brain Dynamics: The Role of Reduced Cerebrospinal Fluid Reabsorption

Linninger, Andreas A.

104

Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

  University of California eScholarship Repository

Summary: sarcoplasmic reticulum CA 2+ -ATPase, phospholamban, and gap junction proteinsarcoplasmic reticulum CA 2+ -ATPase, phospholamban, and gap junction proteinsarcoplasmic reticulum CA 2+ -ATPase, an 80% reduction in phospholamban, and a 60% reduction in gap junction protein

Yamazaki, Katrina Go
2009-01-01

105

A clinical feasibility study of atrial and ventricular electromechanical wave imaging

  Biology and Medicine Websites

Summary: -lead ECG and invasive methods are also limited in their utility for monitoring response to cardiac and monitoring. Electromechanical wave imaging (EWI) is an ultrasound-based method that has previously been shown for the first time in a patient with both AFL and right bundle branch block (RBBB). RESULTS

Konofagou, Elisa E.

106

Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia.

  University of California eScholarship Repository

Summary: outcome variable in a multivariate repeated-measures ANOVA model to account for the repeated measurementoutcome model such as random-effects regression, because the small number of subjects with more than two lon- gitudinal measurements (


2007-01-01

107

AVALIAÃÃO DA FUNÃÃO VENTRICULAR ESQUERDA EM RATOS SUBMETIDOS Ã DESNUTRIÃÃO PROTÃICA.

  Open Access Theses and Dissertations

Summary: ??A desnutriÃÃo protÃica pode afetar o funcionamento dos processos fisiolÃgicos do organismo. Nosso laboratÃrio mostrou que a desnutriÃÃo protÃica pÃs desmame produz alteraÃÃes envolvidas direta… (more)

Arthur Moreira Alves
2011-01-01

108

Expression and localization of P2 nucleotide receptor subtypes during development of the lateral ventricular

  Biology and Medicine Websites

Summary: in the developing rat choroid plexus shows that gradients between blood and CSF for sodium, potassium and chloride located in the choroidal epithelial cells. The ion gradients drive the subsequent movement of water across the polarized epithelia into the ventricles through the water-channel aquaporin 1 in the apical (Nielsen et al

Burnstock, Geoffrey

109

Hyperbolic Ricci Flow and Geodesic Curve Lifting for Consistent Ventricular Surface

  Mathematics Websites

Summary: , Leslie C. Baxter5 , Eric M. Reiman4 , Richard J. Caselli6 , Yalin Wang1 , and for the Alzheimer's Disease Banner Alzheimer's Institute and Banner Good Samaritan PET Center, AZ, USA 5 Human Brain Imaging impairment (MCI) subjects from the Alzheimer's Disease Neuroimag- ing Initiative (ADNI), including 71

Wang, Yalin

110

Automated ventricular mapping with multi-atlas fluid image alignment reveals genetic effects in Alzheimer's disease

  Biology and Medicine Websites

Summary: in Alzheimer's disease Yi-Yu Chou,a Natasha Leporé,a Greig I. de Zubicaray,b Owen T. Carmichael,c James T Science, University of California, Davis, CA, USA d Department of Neurology and Alzheimer's Disease to MRIs from 17 Alzheimer's disease (AD) patients and 13 age- and gender-matched healthy elderly control

Thompson, Paul

111

PointTracked Quantitative Analysis of Left Ventricular Motion from 3D Image Sequences

  Biology and Medicine Websites

Summary: of Electrical Engineering, Diagnostic Radiology, and Medicine Yale University New Haven, CT 06520 motion parameters (path length and thickness changes) in detecting myocardial injury is tested quantitative estimates of the location and extent of ischemic myocardial injury. It is also felt that image

Duncan, James S.

112

Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease.

  Open Access Theses and Dissertations

Summary: ?? Introduction: Chronic kidney disease (CKD) is associated with significantly increased risk of cardiovascular morbidity and mortality. In the general population, adiponectin, a hormone produced… (more)

Lo, Megan M.
2011-01-01

113

P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium

  Biology and Medicine Websites

Summary: bands from rat vas deferens. The most prominent band in human left ventricles was at 95 kDa, possibly of the antibody with its epitope peptide, the 45 and 60 kDa bands almost disappeared and the 95 and 120 kDa bands the two proteins often appeared to be spatially discrete. Western blotting detected four major bands at 45

Burnstock, Geoffrey

114

Left Ventricular Hypertrophy Reversal and Prevention of Diabetes Two Birds With One Stone?

  CiteSeer

Summary: Information about reprints can be found online at: Reprints: document. Permissions and Rights Question and Answer this process is available in the click Request Permissions in the middle column of the Web page under Services. Further information about Office. Once the online version of the published article for which permission is being requested is located, can be obtained via RightsLink, a service of the Copyright Clearance Center, not the EditorialHypertensionin Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions: by guest on March 5,

Matteo Pirro; Elmo Mannarino; Matteo Pirro; Elmo Mannarino

115

MULTIVARIATE TENSOR-BASED MORPHOMETRY ON SURFACES: APPLICATION TO MAPPING VENTRICULAR CHANGES IN HIV/AIDS

  Biology and Medicine Websites

Summary: tensors that encode the full information in the deformation tensor fields. We applied this framework to 3D areas of statistically signifi- cant deformation even in a relatively small test dataset - from 11 subjects with HIV/AIDS and 8 matched healthy controls. For comparison, we also applied other four TBM

Thompson, Paul

116

Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

  University of California eScholarship Repository

Summary: we demonstrated that inflammation induced MMP activity andinflammation, reactive oxygen species (ROS) generation, and matrix metalloproteinase (MMP)MMP-2 activity (data not shown). 2.4 Discussion Our previously published study evidenced local dyskinesis induced inflammation

Yamazaki, Katrina Go
2009-01-01

117

Artificial muscle technology applied towards treating ischemic mitral regurgitation caused by left ventricular remodeling

  MIT - DSpace

Summary: Ischemic Mitral Regurgitation (MR) affects a large portion of patients suffering from ischemic heart disease. Significant MR develops in one quarter to one third of patients who suffer from ischemic heart disease and doubles ...

Sabourin, Nicaulas A. (Nicaulas Alexandre), 1978-
2004-01-01

118

GLP-1 CellBead Therapy for the Prevention of Left Ventricular Dysfunction in Pigs.

  Open Access Theses and Dissertations

Summary: ??Background: Stem cells are a promising therapy for regeneration following myocardial infarction (MI). Another therapy currently under investigation for MI is glucagon-like peptide-1 (GLP-1), a… (more)

Wright, Elizabeth Joanne
2013-01-01

119

ARTICLE IN PRESS Mapping hippocampal and ventricular change in Alzheimer disease

  Biology and Medicine Websites

Summary: controls (age: 71.4 F 0.9 years), each scanned twice (2.1 F 0.4 years apart). 3D parametric mesh models change in dementia. They are readily derived from repeat (longitudinal) 3D MRI scans to assess tissue systematic patterns of atrophy. As an index of radial atrophy, 3D distance fields were generated relating

Thompson, Paul

120

SURFACE-BASED COMPUTATIONAL ANATOMY TECHNIQUES REVEAL VENTRICULAR AND HIPPOCAMPAL ABNORMALITIES IN ADOLESCENTS

  Biology and Medicine Websites

Summary: . 3D T1-weighted MRI scans of 12 COS and 12 matched healthy subjects were acquired longitudinally over using a 3D distance field to measure the distance of each surface boundary point to a 3D medial curve). Longitudinal scanning allowed us to establish the timing and dynamic spread of these disease-specific changes

Thompson, Paul

121

Three-dimensional organisation of re-entrant propagation during experimental ventricular brilation

  Mathematics Websites

Summary: to be produced by the breakdown of re-entrant propagation waves of excitation into multiple re-entrant sources irregular electrical wave activity on the surface of the heart during experimentally induced #12;brillation. These re-entrant waves may be idealised as spiral waves in two dimensional, and scroll waves in three

Biktashev, Vadim N.

122

Multi-Scale Modeling in Rodent Ventricular Myocytes: Contributions of structural and functional heterogeneities to

  Mathematics Websites

Summary: intracellular Ca2+ required for myofilament activation is stored [1], [8]-[11]. Early studies of cardiac muscle the sarcolemma contain specialized proteins [1], [4], [14]. The sarcolemmal L-type Ca2+ channels (LCC but one [17] have demonstrated also that marked variations in the distribution of Ca2+ -handling proteins

Holst, Michael J.

123

Carbon Monoxide Pollution Promotes Cardiac Remodeling and Ventricular Arrhythmia in Healthy Rats

  Computer Technologies and Information Sciences Websites

Summary: worldwide by outdoor air pollution caused by vehicles and industrial emissions (http://www.who.int; http:// www.infoforhealth.org). Notably, air pollution increases the risk of mortality from cardiovascular investigating the effects of urban air pollution in humans are mainly restricted to epide- miological studies

Boyer, Edmond

124

Eur Radiol . Author manuscript Relation of the ischaemic substrate to left ventricular remodelling by

  Physics Websites

Summary: -registered cine and contrast-enhanced CMR and histopathology at day 3 for assessment of MAR and IS (group 1 IS was 12.7 6.4 and 12.7 6.9 of total LV myocardial mass on CMR (late-enhancement technique) and.garot@icps.com.fr > Abstract Objectives Contrast-enhanced cardiac magnetic resonance (CMR) for infarct sizing has been

Paris-Sud XI, Université de

125

Three-Dimensional Left and Right Ventricular Strain Distributions in The Rat Heart /

  University of California eScholarship Repository

Summary: anatomical MRI images and the fiber-sheet orientations. Thethe fiber architecture of the heart. The anatomical imagesimages and this data was filtered to remove noise using custom-built MATLAB code. The fiber

Barrio, Martin J.
2013-01-01

126

Simultaneous Estimation of Left Ventricular Motion and Material Properties with Maximum a Posteriori Strategy

  Computer Technologies and Information Sciences Websites

Summary: ]. Conjugate to biomechanics efforts, all image analysis works are based on the premise that mechanical to its technical merits as a challenging non-rigid motion and structural integrity analysis problem smoother, that produce a sequence of kinematics state and material parameter estimates from the entire

Shi, Pengcheng

127

Bootstrap Feature Selection in Support Vector Machines for Ventricular Fibrillation Detection

  Computer Technologies and Information Sciences Websites

Summary: , 28911, Legan´es, Madrid - Spain 2- University of Valencia - Dept. of Electrical Engineering (GPDS) Doctor Moliner 50, 46100, Burjassot, Valencia - Spain 3- University Hospital Virgen de la Arrixaca - Lab. of Electrophysiology Ct. Madrid-Cartagena s/n, 30120, El Palmar, Murcia - Spain Abstract. Support Vector Machines (SVM

Camps-Valls, Gustavo

128

Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep

  Biology and Medicine Websites

Summary: aneurysm plication (n 8) or sham operations (n 5). Six weeks after this operation, hearts were excised system. Transmural samples of the helix angles were compared at the border zone of the aneurysm or repair. Results: The helical myofiber orientation did not change after myocardial infarction. However, aneurysm

Duncan, James S.

129

Mechanisms of Right-ventricular Dysfunction in a Rat Model of Chronic Neonatal Pulmonary Hypertension.

  Open Access Theses and Dissertations

Summary: ??Chronic neonatal pulmonary hypertension (PHT) frequently presents with rightventricular (RV) dysfunction. In neonatal rats exposed to chronic hypoxia, RV dysfunction is reversed by sustained rescue… (more)

Gosal, Kiranjot
2013-01-01

130

Original Research Article Estimation of right atrial and ventricular hemodynamics by

  Engineering Websites

Summary: alternative to the invasive assessment of coronary artery disease. However, a specific limitation of CTCA (TRV). SVC area change with contrast injection at the level of the bifurcation of the pulmonary artery noninvasive alternative to the invasive assessment of coronary artery disease. However, a specific limitation

Mittal, Rajat

131

Right ventricular ejection fraction from equilibrium and first pass scintigraphic cardiac images

  Texas A&M University - TxSpace

Summary: inside the ED heart contour are selected. Cardiac cycles of 1 through 15 are considered for this nomination because the bolus is safely assumed to leave the heart after 15th cardiac cycle under the rest condition. This procedure consists... allow the temporal separatiou of RV from other chambers, they are too noisy for the accurate delineation of the outline of the ventricles, which is needed for computing the ejection fraction. In our approach, first the heart boundary is extracted...

Nakamura, Eiji
2012-06-07

132

The effect of myocardial uptake of epinephrine on ventricular fibrillation threshold

  Texas A&M University - TxSpace

Summary: ), and an immobilization stress model. EPI was initially infused at 1. 6 ug/min and then adjusted to maintain a heart rate (HR) of 1. 5 to 2 times pre-infusion rate for 15, 30, 45, and 60 minutes. At 15 minutes post-infusion, HR and plasma EPI concentration had... indirect methods, such as measuring the blood pressure, heart rate, etc. More recently, methods have been been developed that enable the direct quantitation of amounts of catecholamine contained in the blood and tissues. Some of the best known methods...

Hurst, Terry William
2012-06-07

133

Ventricular dyskinesis induced loss of contractile function and epicardial inflammation : role of cellular adhesion molecules

  University of California eScholarship Repository

Summary: heart failure, there was an increase in mitogen activated kinase p38, calcium-calmodulin-dependent kinase, tumorheart failure, there was an increase in mitogen activated kinase p38, calcium-calmodulin-dependent kinase, tumor

Yamazaki, Katrina Go
2009-01-01

134

POSTER PRESENTATION Open Access The 3d left ventricular geometry integrated

  Physics Websites

Summary: systolic pressures (PSP) resulting in MWS. For AVS patients, the echocardiographic trans- aortic valve maximal gradient was added to the tono- metric PSP. Results Ejection fraction was homogeneous between the three subgroups (C1=64±5, C2=66±7, AVS=72±8 %) The signif- icant and gradual elevation in PSP found

Paris-Sud XI, Université de

135

VENTRICULAR MAPS IN 804 SUBJECTS CORRELATE WITH COGNITIVE DECLINE, CSF PATHOLOGY, AND IMMINENT ALZHEIMER'S DISEASE

  Biology and Medicine Websites

Summary: ALZHEIMER'S DISEASE Yi-Yu Chou1 , Natasha Leporé1 , Priya Saharan1 , Sarah K. Madsen1 , Xue Hua1 , Clifford. Thompson1 and the Alzheimer's Disease Neuroimaging Initiative (ADNI) 1 Laboratory of Neuro Imaging, Dept ABSTRACT There is an urgent need for neuroimaging biomarkers of Alzheimer's disease (AD) that correlate

Thompson, Paul

136

Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy

  Engineering Websites

Summary: of a narrow catalog of the functionally most important genes regulating ion homeostasis. We focused, the gene crucial for Na+ and K+ homeostasis. Thus, our cell- specific molecular profiling defined new with Ca2+ homeostasis and energy metabolism. However, some of the implicated genes may be secondary to ICM


137

Modeling, Estimation and Control of Cardiovascular Systems with A Left Ventricular Assist Device

  Engineering Websites

Summary: to approximate the response of human cardiovascular circulatory system. This system model has one critical time as test environments for human cardiovascular circulatory systems with a left ventric- ular assist device patient are restored back to the normal physiologic range. Keywords: Cardiovascular circulatory system

Wu, Yi

138

Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system

  University of California eScholarship Repository

Summary: parenchyma. Alternatively, drug-targeting to the CP epithelial cellsparenchyma in all treatments. capable of targeting CP epithelial cellscells of the choroid plexus. Little staining is detected in brain parenchyma


2011-01-01

139

Differences in the Cerebral Hemodynamics Regulation Mechanisms of Premature Infants with Intra-Ventricular Hemorrhage Assessed by

  Engineering Websites

Summary: hemodynamics regulation consists of several mechanisms that try to keep brain homeostasis. In premature infants their brain to damage. The status of the cerebral regulation mechanism is classically assessed by measuring of blood gases, with surrogate measurements for cerebral blood flow, such as brain tissue oxygenation (r


140

Função ventricular esquerda e respostas cardiorrespiratórias após reabilitação cardíaca hospitalar em pacientes submetidos à cirurgia de revascularização do miocárdio.

  Open Access Theses and Dissertations

Summary: ??It is well-known that cardiac autonomic and pulmonary function are impaired after coronary artery bypass surgery (CABG). Strategies resulting in beneficial cardiorespiratory responses as soon… (more)

Renata Gonçalves Mendes
2008-01-01

141

Evaluation of external ventricular drain complications and the use of a procedure-targeted image-guidance system

  MIT - DSpace

Summary: Access to the cerebral ventricle (e.g. ventriculostomy) is required to manage multiple life-threatening ailments. It can be done either in the operating room or at the bedside to relieve increased intracranial pressure or ...

Patil, Vaibhav Devidas
2011-01-01

142

Clinical epidemiology of cardiac disease in dialysis patients: left ventricular hypertrophy, ischemic heart disease and cardiac failure. Semin Dial 2003

  CiteSeer

Summary: The annual mortality from cardiovascular disease in dialysis patients is substantially higher than in the general population (Figure 1) (1). The 5-yr survival of men ?64 yr old starting dialysis is worse than that of men with colon cancer and prostate cancer (2). The 5-yr survival of women ?64 yr old starting dialysis is worse than that of women with breast cancer and colon cancer (2). About half the deaths in dialysis patients are attributed to cardiovascular disease (2). Hospitalizations of dialysis patients occur frequently and about one-third are the result of cardiovascular disease (2). Despite enormous morbidity and premature mortality resulting from cardiovascular disease, it is only recently that the clinical epidemiology of cardiovascular disease in chronic renal failure has become a major focus of nephrology research. A task force convened by the National Kidney Foundation

Patrick S. Parfrey; Robert N. Foley

143

A GPU Accelerated Convex Max-Flow Approach to Segmentation of 4-D Left-Ventricular Ultrasound

  Engineering Websites

Summary: . The foreground region is modeled using a known (a-priori learned) statistical distribution and then segmented-flow and min-cut models Figure : Flow Configurations. Left: spatially discrete (classical graph based) [2 at iteration i; ui+1 ui u+ u+ u- u- ui+1 ui u- (a) (b) The continuous max-flow model The continuous max

Alberta, University of

144

The 12 cc Penn State Pediatric Ventricular Assist Device: A Flow Visualization Study of Bridge-to-Recovery and Weaning.

  Open Access Theses and Dissertations

Summary: ??While mechanical circulatory support systems have shown success as bridge-to-transplant devices for end-stage heart failure patients, recent evidence shows that sufficient myocardial recovery may occur… (more)

Roszelle, Breigh
2010-01-01

145

QUANTITATIVE GENETIC MODELING OF LATERAL VENTRICULAR SHAPE AND VOLUME USING MULTI-ATLAS FLUID IMAGE ALIGNMENT IN TWINS

  Biology and Medicine Websites

Summary: ALIGNMENT IN TWINS Yi-Yu Chou1 , Natasha Leporé1 , Marina Barysheva1 , Ming-Chang Chiang1 , Katie McMahon2 Image Alignment") to fluidly propagate hand-labeled parameterized surface meshes into 116 scans of twins of MRI scans from healthy individuals with known genetic resemblance (e.g., twins). Genetic models can

Thompson, Paul

146

Alternans and higher-order rhythms in an ionic model of a sheet of ischemic ventricular muscle

  Biology and Medicine Websites

Summary: Humberto Arcea) Departamento de Fi´sica, Facultad de Ciencias, Universidad Nacional Auto´noma de Me´xico, Apartado Postal 70-542, 04510 Me´xico, Distrito Federal, Me´xico Aoxiang Xu Department of Physiology Nacional Auto´noma de Me´xico, Apartado Postal 70-542, 04510 Me´xico, Distrito Federal, Me´xico Michael R

Guevara, Michael R.

147

Case Report Transient Global Amnesia after Ablation of Premature Ventricular Beats Arising from the Right Coronary Cusp

  CiteSeer

Summary: A 58-year-old female underwent PVC ablation within the right coronary cusp for symptomatic PVCs and suspected PVC-induced cardiomyopathy. Immediately after the procedure, she started to complain about feelings of impending doom, disorientation to time and place, and amnesia regarding the procedure. No sensory or motor deficits could be elicited. A thromboembolic event was suspected and she was evaluated by a neurologist. CT scan of her brain was negative. She was diagnosed with transient global amnesia and her mentation returned to baseline within 4 hours after the procedure.

Gopi Dandamudi Md

148

Relation of the ischaemic substrate to left ventricular remodelling by cardiac magnetic resonance at 1.5T in

  Physics Websites

Summary: ;20(5):1214-20" DOI : 10.1007/s00330-009-1660-7 #12;2 Abstract Objectives: Contrast-enhanced cardiac magnetic myocardial mass on CMR (late-enhancement technique) and histopathology (P=0.52; r=0.93). No significant was induced in 16 rabbits. Ten animals underwent cross-registered cine and contrast-enhanced CMR

Paris-Sud XI, Université de

149

Abstract--The purpose of this study, was to asses whether LF/(LF+HF) obtained from ventricular repolarization

  Physics Websites

Summary: Altuve is with the Industrial Technology Department, Simon Bolivar University, Caracas, Venezuela (e, Caracas, Venezuela (e-mail: swong@usb.ve). Gianfranco Passariello is with the Electronic and Circuit Department, Simon Bolivar University, Caracas, Venezuela (e-mail: gpass@usb.ve). Guy Carrault

Paris-Sud XI, Université de

150

The accompanying paper (Vaughan-Jones et al. 2002) reported that, in rabbit ventricular myocytes, the apparent

  Biology and Medicine Websites

Summary: inorganic ions like Na+ or K+ . This value of DH app represents the intrinsic mobility of H+ equivalents of cytoplasmic acid is likely to be limited by the mobility of intracellular buffers, as these bind almost all intracellular acid (Junge & McLaughlin, 1987; Irving et al. 1990). In cardiomyocytes, intrinsic H^ mobility

Keener, James P.

151

Effects of Protein Phosphatase and Kinase Inhibitors on Ca2 and Cl Currents in Guinea Pig Ventricular Myocytes

  Biology and Medicine Websites

Summary: Effects of Protein Phosphatase and Kinase Inhibitors on Ca2 and Cl Currents in Guinea Pig of this study was to compare the effects of various protein phosphatase and protein kinase inhibitors, it is not clear whether both of these channels are regulated in concert by protein kinase A (PKA) or whether


152

THE FUNCTIONAL ROLES OF THE LATERAL PYLORIC AND VENTRICULAR DILATOR NEURONS IN THE PYLORIC NETWORK OF THE LOBSTER,

  Biology and Medicine Websites

Summary: . When sufficient current is injected into the pacemaker Anterior Burster (AB) neuron to force pacemaker and entrains the other network neurons to follow its slow cycling. Hyperpolarization studies have slowed rhythm is VD neuron driven and mediated onto the network pacemaker by the LP neuron. Finally

Weaver, Adam Lee

153

Three Dimensional Speckle Tracking Based Strain Imaging Identifies Alterations in Dynamic Left Ventricular Function after Cardiac Surgery

  University of California eScholarship Repository

Summary: outcomes. 1 While open heart surgery with cardiopulmonaryafter cardiac surgery. European heart journal cardiovascularsurgery for aortic insufficiency (Combined). Exclusion criteria were arrhythmias (such as atrial fibrillation), congenital heart

Howard-Quijano, Kimberly
2014-01-01

154

Int Conf IEEE Engineering in Medicine and Biology Society 1999, pages 848-851 Three-Dimensional Regional Left Ventricular

  Biology and Medicine Websites

Summary: were implanted in two re- gions of the left ventricle in an open chest canine preparation (n = 6 the extent of in- jury following coronary artery occlusion. Understanding how myocardial ischemia alters 3D

Duncan, James S.

155

Connexin 43 Remodeling Contribute To Slowed Conduction Velocity In An Irreversible Arrhythmogenic Canine Model Of Non-Ischemic Heart Failure.

  Open Access Theses and Dissertations

Summary: ??Heart failure is associated with a high mortality due to ventricular tachycardia leading to ventricular fibrillation that could arise from impaired conduction velocity. Myocardial conduction… (more)

Yan, Jiajie
2012-01-01

156

V.N. Biktashev & A.V. Holden ``Reentrant activity and its control by resonant drift in a twodimensional model of isotropic homogeneous ventricular tissue'' Proc Roy Soc

  Mathematics Websites

Summary: ­ gating variables, 0 . . . 1 ffl [Na + ] i , [K + ] i , [Ca 2+ ] i ­ intracellular ion concentrations, mM ffl [Ca 2+ ] up , [Ca 2+ ] rel , [Ca 2+ ] calmod , [Ca 2+ ] trop ­ intracellular partial [Ca 2 NaK + I Na + I bNa + I siNa + I NaCa + I siCa + I bCa ) â?? m = 200(V + 41) 1 \\Gamma exp [\\Gamma0:1(V

Biktashev, Vadim N.

157

A GPU Accelerated Convex Max-Flow Approach to Segmentation of 4-D Left-Ventricular Ultrasound Kumaradevan Punithakumar1,2

  Engineering Websites

Summary: is modeled using a known (a-priori learned) statistical distribution and then segmented from its background of the convex max-flow min-cut optimization process. The max-flow and min-cut models Figure : Flow ui u- (a) (b) The continuous max-flow model The continuous max-flow model can be formulated by: max

Alberta, University of

158

TOMM40 rs2075650, TOMM40 rs157580 and TOMM40 PolyT Polymorphism Effects on Ventricular Enlargement in Individuals with and without Mild Cognitive Impairment

  Biology and Medicine Websites

Summary: which some believe is the underlying etiology in the pathogenesis of the metabolic syndrome. · APOE 4-infected individuals age, understanding how components of the metabolic syndrome and APOE 4 influence Factors and APOE 4 On Brain Microstructure and Cognition in HIV in the HAART Era Beau Nakamoto1,4, Neda

Thompson, Paul

159

Mechanical load-dependent regulation of gene expression in monocrotaline-induced right ventricular hypertrophy in the rat. Circ Res 93: 230-237. Epub 2003

  CiteSeer

Summary: Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation Research can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at:

Harald Kögler; Oliver Hartmann; Kirsten Leineweber; Phuc Nguyen Van; Peter Schott; Otto-erich Brodde; Gerd Hasenfuss; Harald Kögler; Oliver Hartmann; Kirsten Leineweber; Phuc Nguyen Van; Peter Schott; Otto-erich Brodde; Gerd Hasenfuss
2003-01-01

160

Terapia periodontal não-cirúrgica reduz pressão arterial, massa ventricular esquerda, disfunção endotelial e níveis plasmáticos de proteína C-reativa, interleucina 6 e fibrinogênio.

  Open Access Theses and Dissertations

Summary: ??Evidências recentes sugerem que as doenças periodontais podem desempenhar um papel relevante na etiologia e patogênese de doenças cardiovasculares e hipertensão arterial. A resposta inflamatória,… (more)

Fábio Vidal Marques
2011-01-01

161

Busca por genes diferencialmente expressos em resposta a indução de hipertrofia ventricular em rato (Rattus norvegicus) atraves da tecnica de microarranjos de DNA.

  Open Access Theses and Dissertations

Summary: ??Myocardial hypertrophy is one of the major responses to hemodynamic overload imposed by arterial hypertension. This elicits several histological and physiological alterations that affect the… (more)

Ana Carolina Deckmann
2004-01-01

162

Finding Hidden Patterns in Complex Ventricular Ectopy V Schulte-Frohlinde'i2,Y Ashkenazy', PCh Ivanov'13, A Morley-Davies4,L Glass5,

  Materials Science Websites

Summary: pause. The distribution of the PVCs appears random. PVCs (#PVC>5000 in 24 hours). Here, we choose three subjects that show different patterns in their temporal PVC distribution. The sampling rate is 128/s. 3

Stanley, H. Eugene

163

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection

  University of Cambridge - Dspace

Summary: and inflammation. Full genome microarrays of brains reflected inflammation causing neuronal damage (Gfap), effects on host cell protein processing (ubiquitin ligase), synapse remodeling (Complement 1q), and also increased expression of PD-1L (a ligand that allows...

Hermes, Gretchen; Ajioka, James W; Kelly, Krystyna A; Mui, Ernest; Roberts, Fiona; Kasza, Kristen; Mayr, Thomas; Kirisits, Michael J; Wollman, Robert; Ferguson, David J P; Roberts, Craig W; Hwang, Jong-Hee; Trendler, Toria; Kennan, Richard P; Suzuki, Yasuhiro; Reardon, Catherine; Hickey, Adam William; Chen, Lieping; McLeod, Rima
2008-10-23

164

BANDO DI SELEZIONE PER IL CONFERIMENTO DI 1 ASSEGNO PER LA COLLABORAZIONE AD ATTIVITA' DI RICERCA

  Physics Websites

Summary: in left ventricular assist device (LVAD) and autologous stem cell combined therapy in left ventricular assist device (LVAD) and autologous stem cell combined therapy (LVAD) e cellule staminali autologhe" ­ "Boosting cardiac regeneration: breakthrough

Guidoni, Leonardo

165

Is it Safe? Adverse drug effects and cardiac arrhythmias.

  Open Access Theses and Dissertations

Summary: ??The potentially life-threatening polymorphic ventricular arrhythmia Torsade de Pointes (TdP) generally occurs in the setting of delayed ventricular repolarization, as reflected on the ECG by… (more)

Varkevisser, R.
2014-01-01

166

unknown title

  CiteSeer

Summary: Effects of cardiac rehabilitation on functional capacity and quality of life in patients with normal and impaired left ventricular function Effects of cardiac rehabilitation on functional capacity and quality of life in patients with normal and impaired left ventricular function

Wybe Nieuwland; Wybe Nieuwland; Cip-gegevens Koninklijke Bibliotheek; Den Haag; Nieuwland W; Wybe Nieuwland; Prof. Dr. D. Post

167

In The News Monday, March 14, 2011

  Engineering Websites

Summary: ,' is now available (see also ). "Obesity is a risk factor for hypertension (HTN) and left ventricular - () -- A new study, 'Obesity in adolescence is associated with left ventricular hypertrophy and hypertension

Arizona, University of

168

The Experiences of Women Who Live with an Implantable Cardioverter-Defibrillator (lCD).

  Open Access Theses and Dissertations

Summary: ??The implantable cardioverter defibrillator (lCD) is the most effective treatment available for terminating potentially life-threatening ventricular fibrillation and ventricular tachycardia. The lCD detects and attempts… (more)

Smith, Jenea Mary
2009-01-01

169

Sustained High Quality of Life in a 5-Year Long Term Follow-up after Successful Ablation for Supra-Ventricular Tachycardia. Results from a large Retrospective Patient Cohort

  CiteSeer

Summary: Introduction: The ablation of supraventricular tachycardias (SVT) using radiofrequency energy (RF) is a procedure with a high primary success rate. However, there is a scarcity of data regarding the long term outcome, particularly with respect to quality of life (QoL). Methods and Results: In this retrospective single-center study, 454 patients who underwent ablation of SVT between 2002 and 2007 received a detailed questionnaire addressing

Axel Meissner; Irini Stifoudi; Peter Weismüller; Max-olav Schrage; Petra Maagh; Martin Christ; Thomas Butz; Gunnar Plehn

170

Impact of Glycemic Therapy on Myocardial Sympathetic Neuronal Integrity and Left Ventricular Function in Insulin Resistant Diabetic Rats: Serial Evaluation by 11C-meta-Hydroxyephedrine Positron Emission Tomography .

  Open Access Theses and Dissertations

Summary: ??Diagnosis of diabetes mellitus, presence of hyperglycemia, and/or insulin resistance confer cardiovascular risk, particularly for diastolic dysfunction. Diabetes is associated with elevated myocardial norepinephrine (NE)… (more)

Thackeray, James
2012-01-01

171

V.N. Biktashev & A.V. Holden "Re-entrant activity and its control by resonant drift in a two-dimensional model of isotropic homogeneous ventricular tissue" Proc Roy Soc

  Mathematics Websites

Summary: + IsiK + IbK + INaK + INa + IbNa + IsiNa + INaCa + IsiCa + IbCa) m = 200(V + 41) 1 - exp [-0.1(V + 41Na [Na+ ]o 140 + 3INaK + 3INaCa + IsiNa) [K+]i = -1 ViF (IK + IK1 + IsiK + IbK + Ito - 2INaK) [Ca2+ ]i = -1 2ViF (IsiCa + IbCa - 2INaCa) - Iup + Irel VSRupVrel ViVup - d dt [Ca2+ ]calmod - d dt [Ca2+ ]trop

Biktashev, Vadim N.

172

Utilization of fatigued and non-fatigued isolated guinea-pig papillary muscles and ventricular myocytes on the comparison of inotropic, chronotropic and intracellular calcium changes induced by monensin and digoxin.

  Open Access Theses and Dissertations

Summary: ??Experiment 1. We investigated the effects of monensin and digoxin on contraction force (CF), initial contraction velocity (ICV), average contraction velocity (ACV), initial relaxation velocity… (more)

Meral, Ismail
1996-01-01

173

Please cite this article in press as: Linninger A, et al. An impedance sensor to monitor and control cerebral ventricular volume. Med Eng Phys (2009), doi:10.1016/j.medengphy.2009.03.011

  Engineering Websites

Summary: . The measurement principle of the sensor exploits electrical conductivity differ- ences between the cerebrospinal five years, even though patients need them for their entire life. In children, the failure rate

Linninger, Andreas A.

174

Stability and Kinetic Properties of C5-Domain from Myosin Binding Protein C and its Mutants

  Physics Websites

Summary: , correlated to Familial Hypertrophic Cardiomyopathy, has been assessed through molecular dynamics simulations Cardiomyopathy (FHC) is a cardiac disorder characterized by left ventricular hypertrophy. The prevalence

Cecconi, Fabio

175

SARCOPLASMIC RETICULUM CALCIUM CYCLING AND CARDIAC DISEASE.

  Open Access Theses and Dissertations

Summary: ??Heart failure is a complex syndrome characterized by left ventricular dysfunction, myocardial remodeling, and biochemical alterations. Several signaling pathways are involved in the induction of… (more)

GREGORY, KIMBERLY NICOLE
2005-01-01

176

Early detection of broken hearts in cancer: Bevacizumab and Sunitinib mediated cardiotoxicity.

  Open Access Theses and Dissertations

Summary: ??Background: Although Bevacizumab (BVZ) and Sunitinib (SNT) prolong survival in cancer patients, an unanticipated side-effect is cardiotoxicity. Early indices of left ventricular (LV) systolic dysfunction… (more)

Bordun, Kimberly-Ann
2014-01-01

177

Noninvasive cardioneural signal extraction.

  Open Access Theses and Dissertations

Summary: ??Heart activities are governed by the sympathetic and parasympathetic nervous system. Changes in these neural signals influence the development of arrhythmias, including ventricular tachyarrhythmias that… (more)

Arani, Amirali Shayan
2008-01-01

178

Universittsmedizin Gttingen Publikationen und Hochschulschriften 2008

  Biology and Medicine Websites

Summary: ) Natriuretic peptide vs. clinical information for diagnosis of left ventricular systolic dysfunction in primary and psychological stress responses in adults with attention- deficit/hyperactivity disorder (ADHD

Gollisch, Tim

179

Impact of diastolic dysfunction on physical function and body composition in maintenance hemodialysis patients.

  Open Access Theses and Dissertations

Summary: ??ABSTRACT Background: Cardiovascular (CV) complications are the main cause of death in maintenance hemodialysis (MHD) patients. Although metrics related to left ventricular systolic dysfunction (LVSD)… (more)

Jeong, Jin Hee
2014-01-01

180

Renin-angiotensin-aldosterone system genes and the complex hypertrophic phenotype of hypertrophic cardiomyopathy.

  Open Access Theses and Dissertations

Summary: ??ENGLISH ABSTRACT: Left ventricular hypertrophy (LVH) is a strong independent predictor of cardiovascular morbidity and mortality, while its regression is associated with an improved clinical… (more)

Carstens, Nadia
2012-01-01

181

Regulation of Kinin receptor Expression in Heart Failure with a Focus on Vascular Endothelium.

  Open Access Theses and Dissertations

Summary: ??Accumulating evidence show that kinins, notably bradykinin (BK) and kallidin, have cardioprotective effects. To these include reduction of left ventricular hypertrophy (LVH) and progression of… (more)

Liesmaa, Inka
2010-01-01

182

Effects of Rho-kinase Iinhibition on Established Chronic Hypoxic Pulmonary Hypertension in the Neonatal Rat.

  Open Access Theses and Dissertations

Summary: ??Rationale: Vascular remodeling and right-ventricular (RV) dysfunction are features of refractory pulmonary hypertension (PHT) in human neonates. These features are replicated in rats chronically exposed… (more)

Xu, Emily Zhi
2010-01-01

183

The importance of long axis function -an echocardiographic study with respect to ageing, response to treatment, prediction of survival and effect of warm water immersion.

  Open Access Theses and Dissertations

Summary: ??Echocardiographic M-mode measurement of atrioventricular plane displacement (AVPD) and determination of annular velocity with Tissue Doppler imaging (TDI) is a reliable method to gauge ventricular… (more)

Grüner Sveälv, Bente
2008-01-01

184

Biochemical Changes in Patients with Diabetic Cardiomyopathy during Drug Therapy and The Cardioprotective Effect of Selected Medicinal Plants In Isoproterenol Induced Swiss Albino Rats;.

  Open Access Theses and Dissertations

Summary: ??Diabetic cardiomyopathy characterized by left ventricular dysfunction and LV hypertrophy independent of myocardial ischemia and hypertension could contribute to the increased newlinelife time risk for… (more)

T Kirithika
2015-01-01

185

COMPUTATIONAL SIMULATIONS OF FLOW OVER THE SURFACE OF A FORMED THROMBUS IN A BACKWARD-FACING STEP.

  Open Access Theses and Dissertations

Summary: ??Thrombosis and thromboembolization remain a major impediment to the successful use of cardiovascular devices, such as ventricular assist devices, arterial stents, and artificial heart valves.… (more)

Long, George
2009-01-01

186

Diagnosis and treatment of fetal cardiac disease: A scientific statement from the american heart association

  University of California eScholarship Repository

Summary: parameters of fetal heart failure Cardiac tumors Ventriculartumor that functions as an arteriovenous malformation leading to mas- sive cardiac volume overload, ventricular dilation, AV valve regurgitation, and heart


2014-01-01

187

Cardiomyocyte-Specific Deficiency of Ketone Body Metabolism Promotes Accelerated Pathological Remodeling.

  Open Access Theses and Dissertations

Summary: ??During evolution of adverse ventricular remodeling that culminates in cardiomyopathy and congestive heart failure, myocardial fuel utilization becomes inefficient and inflexible, and mechanistic studies in… (more)

Schugar, Rebecca
2014-01-01

188

? ???????? ??? ?????????????? ??? ??????????????? ??? ????????? ??????? ?? ??? ?????????? ????????.

  Open Access Theses and Dissertations

Summary: ??Aim. To evaluate left ventricular function based on biochemical parameters after administration of levosimendan in patients with acute coronary syndromes (ACS).Material and Methods. The study… (more)

Bostanitis, Ioannis
2014-01-01

189

Intrakoronar injeksjon av benmargsceller ved akutt hjerteinfarkt.

  Open Access Theses and Dissertations

Summary: ??Background: Recently, experimental studies have shown improvement on left ventricular function and reduction in infarct scar size after intracoronary injection of autologous cells derived from… (more)

Meyer, Andre Almvik
2009-01-01

190

Seeding of Titanium Surfaces and Nitinol Stents with Blood-Derived Endothelial Cells.

  Open Access Theses and Dissertations

Summary: ?? Covering the metal surface of blood-contacting cardiovascular implants (stents, ventricular assist devices) with functional endothelium may reduce the incidence of clotting and restenosis complications… (more)

Jantzen, Alexandra Elizabeth
2014-01-01

191

The role of aldosterone in myocardial remodelling.

  Open Access Theses and Dissertations

Summary: ??The pathophysiology of cardiac failure involves activation of the renin-angiotensinaldosterone system that contributes to adverse left ventricular remodelling. This is a complex pathologic process that… (more)

Kotlyar, Eugene
2006-01-01

192

Steven W. Day1 e-mail: sday@alumni.virginia.edu

  Environmental Sciences and Ecology Websites

Summary: , Charlottesville, VA 22903 PIV Measurements of Flow in a Centrifugal Blood Pump: Steady Flow Magnetically suspended left ventricular assist devices have only one moving part, the impeller. The impeller has absolutely flow. DOI: 10.1115/1.1865189 Introduction A left ventricular assist device LVAD can effectively relieve

Day, Steven

193

The heart of non-crocodilian reptiles has two atria supplying the ventricle from the systemic and pulmonary circulations.

  Environmental Sciences and Ecology Websites

Summary: the CV. During ventricular diastole, oxygen-poor blood from the right atrium (RAt) enters the CV and flows across the muscular ridge to enter the CP, while oxygen-rich blood from the left atrium directly fills the CA. Oxygen-poor blood that remains within the CV by onset of ventricular systole

Altimiras, Jordi

194

Plasma cortisol is associated with accelerated brain atrophy: An Alzheimer's Disease Neuroimaging Initiative (ADNI) study

  Biology and Medicine Websites

Summary: Plasma cortisol is associated with accelerated brain atrophy: An Alzheimer's Disease Neuroimaging in Alzheimer's disease and in the healthy elderly; the hippocampus has a high density of glucocorticoid with ventricular shapes. Results: With every 1ng/mL increase in blPC levels, we found up to 1) 80% ventricular

Thompson, Paul

195

Cardiac MyocyteSpecific Excision of the 1 Integrin Gene Results in Myocardial Fibrosis and Cardiac Failure

  Biology and Medicine Websites

Summary: Cardiac Myocyte­Specific Excision of the 1 Integrin Gene Results in Myocardial Fibrosis and Cardiac exclusively in ventricular cardiac myocytes. Animals with homozygous ventricular myocyte 1 integrin gene strong evidence for the importance of 1 integrin in cardiac form and function and indicates

Smith, Desmond J.

196

27J. exp. Biol. 181, 2747 (1993) Printed in Great Britain The Company of Biologists Limited 1993

  Environmental Sciences and Ecology Websites

Summary: using in situ working perfused heart and in vitro isometric ventricular strip preparations. When tested, isometric ventricular strip preparations demonstrated a similar increase in adrenergic sensitivity with cold performance during exercise (Farrell and Jones, 1992). The effects of adrenergic agents, however

Farrell, Anthony P.

197

lffiA Snpteruzn W/ t;Ntvt-R\\ll^ t)l RoMA

  Physics Websites

Summary: and tissue engineering for ischemic heart disease: regional and global left ventricular quantitative analysis and tissue engineering for ischemic heart disease: regional and global left ventricular quantitative analysis cellule staminali cardiache nell'ambito del progetto di ricerca "Evaluation ofregenerative cell therapy

Guidoni, Leonardo

198

Brain Surface Conformal Parameterization with Holomorphic Flow Method and Its Application to HIV/AIDS

  Mathematics Websites

Summary: Brain Surface Conformal Parameterization with Holomorphic Flow Method and Its Application to HIV/AIDS associated with HIV/AIDS. Based on holomorphic one-forms, we obtained conformal parameterization of ventricular geometry and registered lateral ventricular surfaces across 19 subjects (8 controls and 11 HIV/AIDS

Wang, Yalin

199

Cardiac Tissue Structure, Properties, and Performance: A Materials Science Perspective

  Engineering Websites

Summary: Science Program, UW-Madison College of Engineering, Madison, WI 53706, USA; and 3 Department of Cell in biomaterial performance, in which the biomaterial is the tissue compris- ing the ventricular wall and ultimately its performance are inter- connected (Fig. 1). For the ventricular wall tissue that determines

Chesler, Naomi C.

200

Fat Computed tomography (CT)

  CiteSeer

Summary: We report here a case of streaky fat deposition in the middle layer of the left ventricular myocardium, without any underlying etiology, and this was seen on computed tomography coronary angiography. This report suggests that left ventricular middle layer fat deposition should be investigated in order to determine its etiology, the pathogenesis and the prognosis.

Song Soo Kim; Sung Min Ko; Meong Gun Song; Case Report
2009-01-01

201

A multiscale model for eccentric and concentric cardiac growth through sarcomerogenesis

  Materials Science Websites

Summary: , the creation and deposition of new sarcomere units. In response to chronic volume-overload, an increased in cardiomyocyte length, associated with eccentric hypertrophy and ventricular dilation. In response to chronic backward scheme. We explore a generic bi-ventricular heart model in response to volume- and pressure

Parker, Kevin Kit

202

Keystone Symposia is pleased to present Pulmonary Vascular Disease

  Biology and Medicine Websites

Summary: Keystone Symposia is pleased to present Pulmonary Vascular Disease and Right Ventricular and translational research focusing on the discovery of novel pathways in pulmonary vascular disease and right basic and clinical researchers working in the field of pulmonary vascular disease and right ventricular

Gilad, Yoav

203

ISSN: 1524-4539 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online

  Biology and Medicine Websites

Summary: may lead to wave-front destabilizations and initiation of ventricular fibrillation (VF). In a computer alternans and induction of VF in all dogs. Verapamil decreased spatial dispersion of refractoriness. (Circulation. 2008;118:1123-1129.) Key Words: electrophysiology ventricular fibrillation verapamil Wave

Otani, Niels F.

204

Model-driven deformable atlases 1083 Figure 17.5: Partitioning the ventricles into 3D surface elements. A model of the lateral

  Biology and Medicine Websites

Summary: junctions reflect tissue type boundaries at the ventricular surface. For example, caudate, thalamic section of this book.) #12;1084 Brain Image Analysis and Atlas Construction hemispheres. Additional gyral boundaries are represented by parameterized curves lying in the cortical surface. The ventricular system

Thompson, Paul

205

4D Cardiac Reconstruction Using High Resolution CT Images

  Computer Technologies and Information Sciences Websites

Summary: , such as the papillary muscles and the ventricular trabeculae, for the first time, which allows us to quan- titatively structures, such as the papillary muscles, the ventricular trabeculae and the valves, are often difficult to capture in this modality. There has also been work on the 3D cardiac reconstruction from CT im- ages [10

Huang, Junzhou

206

SELECTION PROCEDURE No. 1/2013 SAPIENZA UNIVERSITY OF ROME

  Physics Websites

Summary: regeneration: breakthrough in left ventricular assist device (VAD) and autologous stem cell combined therapy" Interview: "State of the art in the use of ventricular assist device (VAD) and cardiac stem cell therapies therapy and tissue engineering in cardiovascular diseases" Interview: "Limbal and mesenchimal stem cells

Guidoni, Leonardo

207

VOLUME 86, NUMBER 16 P H Y S I C A L R E V I E W L E T T E R S 16 APRIL 2001 Defibrillation via the Elimination of Spiral Turbulence in a Model for Ventricular Fibrillation

  Physics Websites

Summary: behind sudden cardiac death, is turbulent cardiac electrical activity in which rapid, irregular disturbances in the spatiotemporal electrical activation of the heart make it incapable of any concerted as well as injected medication. Electrical defibrillation, though widely used, involves subjecting

Sinha, Sitabhra

208

for the French Cardiomyoplasty Investigators Workgroup: A Carpentier, JC Chachques; F

  CiteSeer

Summary: Dynamic Cardiomyoplasty (DCMP) aims at improving cardiac function in cases of severe heart failure. It consists in anchoring Latissimus Dorsi Muscle (LDM) to failing ventricles. LDM is stimulated in synchrony with ventricular contractions by burst of impulses (6, 31 ms) delivered by a cardiomyostimulator (CM). A retrospective analysis of collective French experience (6 centers) is reported. Since 1985, 212 patients (mean age: 53+/-11y, LVEF = 22+/-9%, NYHA Class III) underwent DCMP in France. Pre-operative ventricular dysfunction was left (68%), right (9%) and biventricular (23%). Longest FU is 20 y. Freedom of cardiac death (or heart transplantation) depended on pre-operative ventricular

O Jegaden; P Mikaeloff; V Bors; A Pavie; T Mesana; D Metras; A Mouly-b; Ini G Fournial; Y Glock; D Roux; T Popof; Jp Elbèze

209

Bioengineering 278: Magnetic Resonance Imaging Laboratory Winter 2012

  Biology and Medicine Websites

Summary: points) 3. Ejection Fraction. Ejection fraction is defined as the fraction of the left ventricular blood. Integrate the flow through the aorta across space and time in order to estimate the total blood flow through

California at San Diego, University of

210

Bioengineering 278: Magnetic Resonance Imaging Laboratory Winter 2013

  Biology and Medicine Websites

Summary: points) 3. Ejection Fraction. Ejection fraction is defined as the fraction of the left ventricular blood. Integrate the flow through the aorta across space and time in order to estimate the total blood flow through

California at San Diego, University of

211

Bioengineering 278: Magnetic Resonance Imaging Laboratory Winter 2011

  Biology and Medicine Websites

Summary: . Ejection Fraction. Ejection fraction is defined as the fraction of the left ventricular blood volume at end the flow through the aorta across space and time in order to estimate the total blood flow through one

California at San Diego, University of

212

Kardiale Magnet-Resonanz-Tomographie bei Patienten vor und nach chirurgischer Ventrikelrekonstruktion – Analyse potentieller Prädiktoren der postoperativen Herzfunktion –.

  Open Access Theses and Dissertations

Summary: ??Die DOR-Plastik (Surgical Ventricular Reconstruction, SVR) ist ein chirurgisches Verfahren zur Rekonstruktion ventrikulärer kardialer Strukturen bei Herzinsuffizienz-Patienten mit apikaler A- und Dyskinesie. Jedoch gibt es… (more)

Hüther, Jan
2012-01-01

213

unknown title

  CiteSeer

Summary: www.elsevier.com/locate/ejheart Previously known and newly diagnosed atrial fibrillation: A major risk indicator after a myocardial infarction complicated by heart failure or left ventricular dysfunction B

Lars Køber A; Karl Swedberg B; John J. V. Mcmurray C; Marc A. Pfeffer D; Eric J. Velazquez E; Rafael Diaz F; Aldo P. Maggioni G; Viatcheslav Mareev H; Grzegorz Opolski I; Frans Van De Werf J; Faiez Zannad K; Georg Ertl L; Scott D. Solomon D; Steven Zelenkofske M; Jean-lucien Rouleau N; Jeffrey D. Leimberger E; Robert M. Califf E
2006-01-01

214

An assay for permeability of the zebrafish embryonic neuroepithelium

  MIT - DSpace

Summary: The brain ventricular system is conserved among vertebrates and is composed of a series of interconnected cavities called brain ventricles, which form during the earliest stages of brain development and are maintained ...

Chang, Jessica T.

215

Appl. Phys. B 72, 859863 (2001) / Digital Object Identifier (DOI) 10.1007/s003400100562 Applied Physics B

  Engineering Websites

Summary: of helicobacter pylori, which causes ventricular ulcers [5]). De- tection of biomedically-produced NO and its absorption lines can be selected to avoid interference from other species such as CO2 and H2O absorbing


216

ARTICLE 1 -RECOGNITION Section 1: This agreement is made and entered into this 14th

  Engineering Websites

Summary: University Transplant Nurses Organization, hereinafter referred to as "OSUTNO," The Ohio State University in the following positions: Lung Transplant Coordinator Ventricular Assist Device Program Coordinator Heart Transplant Coordinator Transplant Coordinator Transplant Discharge Coordinator Non-registered nurses employed


217

Myocardial Macrophage Phenotypic Variation and Cytokine-Mediated Induction of HIV-Associated Cardiac Disease: A Dissertation.

  Open Access Theses and Dissertations

Summary: ??Ventricular dysfunction and dilated cardiomyopathy (DCM) develop among untreated HIV-infected people at much higher rates than among HIV-negative individuals, resulting in significant contributions to morbidity… (more)

Yearley, Jennifer Holmes
2008-01-01

218

Open Access Available online http://ccforum.com/content/10/4/R124

  Physics Websites

Summary: 2006 Published: 30 Aug 2006 Critical Care 2006, 10:R124 (doi:10.1186/cc5033) This article is online at (isolated perfused hearts), myofilament Ca2+ sensitivity (skinned fibers), left ventricular nitric oxide end

Paris-Sud XI, Université de

219

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

  MIT - DSpace

Summary: Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, ...

Majmudar, Maulik D.

220

Mapping myocardial structure-function relations with cardiac diffusion and strain MRI

  MIT - DSpace

Summary: The myocardial structure-function relation is the key to understand the functional design of the ventricular myocardium. While the function of myocardial fibers has been extensively studied, the recently observed laminar ...

Dou, Jiangang, 1972-
2002-01-01

221

An apparatus for high throughput muscle cell experimentation

  MIT - DSpace

Summary: The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

Garcia-Webb, Michael G. (Michael Gregory)
2006-01-01

222

LETTER TO THE EDITOR Open Access ZEB2, a new candidate gene for asplenia

  Computer Technologies and Information Sciences Websites

Summary: by typical facial dysmorphisms, intellectual disability, microcephaly, epilepsy and the possible presence with central depression, saddle nose and a pointed chin), intellectual disability, microcephaly, epilepsy, epilepsy, corpus callosum agenesis, ventricular septal defect and patent ductus arteriosus, club foot

Boyer, Edmond

223

@ .s..f,heN#n AWISO DI CONFERIMENTO DI

  Physics Websites

Summary: and fissue engineering for íschemic heart disease: regional and global left ventricular quantitative analysis staminali cardiache nell'ambito del progetto di ricerca dal titolo ..Evallation of regenerative cell therapy

Guidoni, Leonardo

224

Mitochondrial Translocator Protein (TSPO) ligands prevent doxorubicin-induced mechanical dysfunction and cell death in isolated

  Physics Websites

Summary: , mitochondria, permeability transition pore, ROS, TSPO ligands. Abbreviations: BAPTA, 1,2-bis depression of left ventricular function (Ferreira et al., 2008). A large part of these abnormalities results

Paris-Sud XI, Université de

225

Cardiovascular effects of apelin in vivo in man 

  Edinburgh, University of - Research Archive

Summary: Background The apelin system is a novel peptidic pathway widely expressed in the heart and vasculature. In preclinical studies, apelin receptor agonism mediates nitric oxide-dependent vasodilatation, reduces ventricular ...

Japp, Alan Gordon
2013-07-06

226

Spectral analyses of avian heart value sounds

  Texas A&M University - TxSpace

Summary: Cardiovascular changes which occur in response to cardiac stress affect the heart valve sounds (HVS). We attempted to quantify the effect of pulmonary hypertension and right ventricular (RV) hypertrophy on the frequency spectrum of HVS. A test...

Jeyaseelan, Prithika
1993-01-01

227

Meta-Analysis and Meta-Modelling for Diagnostic Problems Meta-Analysis and Meta-Modelling for

  Mathematics Websites

Summary: a mixed model approach case studies MMSE and Dementia/MCI MOOD and depressive disorders MRS and prostate by Doust et al. (2004) for brain natriuretic peptide (BNP) restriction on studies that use left ventricular

Boehning, Dankmar

228

Atlas-based analysis of cardiac shape and function: correction of regional shape bias due to imaging protocol for population studies

  University of California eScholarship Repository

Summary: GRE imaging in poor heart function may accentuate dif-based analysis of heart shape and function shows promise inheart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function.


2013-01-01

229

VALUTAZIONE DI UNA COMPONENTE A BASSA FREQUENZA DELLA VARIABILITÀ DELLA PRESSIONE ARTERIOSA SISTOLICA IN PAZIENTI CON FIBRILLAZIONE ATRIALE PERSISTENTE E SUA SUCCESSIVA ULTERIORE VALUTAZIONE MEDIANTE LINGUISTIC ANALYSIS.

  Open Access Theses and Dissertations

Summary: ??Atrial fibrillation (AF) is a common arrhythmia characterized by irregular ventricular response. During AF, beat-to-beat variability of arterial pressure (AP) is increased because of continuous… (more)

TERRANOVA, PAOLO
2010-01-01

230

Risk of Chronic Oral Anticoagulation Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction - Retrospective Cross-Sectional Study

  University of Kansas - KU ScholarWorks

Summary: % Mechanical Heart failure, cardiogenic shock, mitral valve dysfunction, aneurysms, cardiac rupture VSD: 0.2% MR: 13% to 45% CHF: 7-8% Arrhythmic Atrial or ventricular arrhythmias, sinus or atrioventricular node dysfunction VFib: 2-4% Embolic Central...

Vanga, Subba Reddy
2013-12-31

231

The development of processing methods for a quantitative histological investigation of rat hearts

  Texas A&M University - TxSpace

Summary: unit of myocardium, further dilation, and a vicious cycle (Braunwald, 2001). It is known that the heart grows and remodels in health (development and exercise hypertrophy) and disease (ventricular aneurysm, post MI, volume and pressure overload...

Jetton, Emily Hope
2004-11-15

232

1. Introduction" The mechanisms for the formation of folding patterns of the

  Computer Technologies and Information Sciences Websites

Summary: , Spheroidal Wave Functions, Stanford Univ. Press, Palo Alto, 1957. 7. D. A. Streigel, M. K. Hurdal, PLo population of radial glial cells (R) is created in the ventricular zone (VZ) which is located in the lateral

Hurdal, Monica K.

233

Short-term High-intensity Interval Training and Continuous Moderate-intensity Training Improve Peak Aerobic Capacity and Diastolic Filling during Exercise.

  Open Access Theses and Dissertations

Summary: ??This study examined the effects of short-term high-intensity interval training (HIT) and continuous moderate-intensity training (CMT) on left ventricular (LV) function in young, healthy men.… (more)

Esfandiari, Sam
2012-01-01

234

Non stationary model of the heartbeat time series in atrial fibrillation

  Mathematics Websites

Summary: . This adaptability relies on two mechanisms. The first one is the influence of the autonomous nervous system, ventricular rate. In this situation the control of the autonomous nervous system on the RR sequence fades

Cammarota, Camillo

235

Hemodynamic Responses to Varying Postural Stress

  Computer Technologies and Information Sciences Websites

Summary: system (The IQ System) was used to evaluate cardiac output (CO), stroke volume (SV), ventricular ejection responsible for circulatory homeostasis both on earth at +1G and in OG. These results may also serve


236

Development/Plasticity/Repair Dorsally and Ventrally Derived Oligodendrocytes Have

  Biology and Medicine Websites

Summary: from the ventral ventricular zone (VZ) under the influence ofSonicHedgehog,butaminorityaregeneratedfromthedorsalVZinaHedgehog is Sonic Hedgehog (SHH) dependent, but dorsally derived OLPs are SHH independent, possibly relying

Richardson, William D.

237

Exercise Training Improves Cardiac and Skeletal Muscle Metabolism in Rats with Pulmonary Arterial Hypertension

  Biology and Medicine Websites

Summary: Exercise Training Improves Cardiac and Skeletal Muscle Metabolism in Rats with Pulmonary Arterial, Ivy Tech Community College, 2 Department of Physical Therapy, Indiana University School of Health promotes right ventricular (RV) and skeletal muscle dysfunction that contributes to reduced exercise

Zhou, Yaoqi

238

Electromagnetic Extracardiac Fields Simulated With

  CiteSeer

Summary: Introduction First idealized models describing the normal activation sequence in the human heart were reported over two decades ago [1, 2]. Mainly due to computational limitations, the models did not include myocardial anisotropy nor physiological propagation. On the basis of anisotropic bidomain theory [3] and cellular automata theory [4], development of more realistic whole-heart models have become feasible [5]. A ventricular model that produces a correct normal activation sequence is a prerequisite for simulating pathological conditions, such as ischemia, infarction or ventricular arrhythmias. A comprehensive model should feature an anatomically accurate geometry, intramural fibrous structure, and a conduction system. Implementation of the ventricular conduction system is a challenge, since it should be flexible enough to allow "rewiring" of the conduction system for each individual case where endocardial mapping data are available. Advances in computer technology have only recent

Bidomain Propagation Model; K. Simelius; J. Nenonen; R. Hren; B. M. Horacek

239

RESEARCH Open Access Repairing chronic myocardial infarction with

  Physics Websites

Summary: engineered tissue in rat promotes angiogenesis and limits ventricular remodeling Pablo Maureira1 Falanga2 and Nguyen Tran2,3 Abstract Background: Tissue engineering scaffold constitutes a new strategy remodeling of chronic MI. Keywords: Chronic myocardial infarction, Tissue engineering, Mesenchymal stem cell

Paris-Sud XI, Université de

240

Paper accepted for presentation at 2002 Joint Meeting of the IEEE EMBS and the BMES, Houston, Texas, 23-26 October 2002. Copyright IEEE 2002. Prediction of Tachyarrhythmia Episodes

  Engineering Websites

Summary: yielded a modulation pattern of the R-R intervals, which was termed "vagal fatigue," that appears-R. The resulting error signal was used to set the "vagal fatigue" indicator. Keywords ­ ventricular fibrillation, VF, tachyarrhythmia, R-R intervals, vagal fatigue, tachycardia, prediction. I. INTRODUCTION


241

ESTIMATING MECHANICAL PROPERTIES OF THE HEART USING DYNAMIC MODELING AND MAGNETIC RESONANCE IMAGING

  Engineering Websites

Summary: ESTIMATING MECHANICAL PROPERTIES OF THE HEART USING DYNAMIC MODELING AND MAGNETIC RESONANCE IMAGING mechanical properties of the heart using magnetic resonance imaging (MRI) tissue-tagging and blood pres- sure, in vivo heart. Clinically, they may be useful for developing ventricular function measures with sufficient

Nehorai, Arye

242

Figure 1: Left ventricle endo-surface segmentation meshes were dissected into two halves, the septum

  Computer Technologies and Information Sciences Websites

Summary: , the septum (on the left) and the free wall (on the right). (a) is from a normal heart, and (b) is from a diseased heart. SHAPE ANALYSIS OF THE LEFT VENTRICULAR ENDOCARDIAL SURFACE AND ITS APPLICATION IN DETECTING *Piedmont Heart Institute, Atlanta, Georgia 30309, USA Introduction The complex 3D geometrical structure

Bhandarkar, Suchendra "Suchi" M.

243

Eur Heart J . Author manuscript Chronic heart rate reduction with ivabradine improves systolic function of

  Physics Websites

Summary: Eur Heart J . Author manuscript Page /1 11 Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect the adaptations of left ventricular function and calcium handling to chronic heart rate reduction with ivabradine

Paris-Sud XI, Université de

244

CLINICAL RESEARCH Heart failure/cardiomyopathy

  Biology and Medicine Websites

Summary: RESEARCH Heart failure/cardiomyopathy Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure Jianwen Wang, Dirar SBakey Heart Center, The Methodist Hospital, Houston, TX 77030-2717, USA Received 27 September 2007; revised 15

Duncan, James S.

245

Name: dhr. prof. dr. J.R. Lahpor Cardiothoracic surgery

  Biology and Medicine Websites

Summary: Medicine Department Division of Heart and Lung Contact details Telephone (+31) 88 755 6179 E-mail address j ventricular assist device: a functional comparison with heart transplantation; Pruijsten R.V., de Jonge N., Kirkels J.H., Klopping C., Doevendans P.A., Ooosterom A., Kemperman H., Lahpor J.R. Neth Heart J 2008

Utrecht, Universiteit

246

Analysis of a Non-linear Partial Difference Equation, and

  Engineering Websites

Summary: States is catastrophic disturbances in electrical rhythms in the heart [7]. Ventricular fibrillation, a particularly lethal phenomenon, consists of the heart being totally ineffectual at pumping blood due to disorganized irregular patterns of electrical activity in the heart. The electrical patterns of excitation

Rand, Richard H.

247

UNIVERSITE MONTPELLIER II Dpartement des Sciences Mathmatiques

  Engineering Websites

Summary: cardiovascular biomechanics and more precisely the numerical simulation of heart support devices such as Ventricular Assist Devices or artificial hearts. The long-term objective is the optimization of such devices typical of an actual artificial organ such as the Carmat heart. The post-doctoral fellow will be part

Mendez, Simon

248

Neurology . Author manuscript MRI predictors of cognitive outcome in early multiple sclerosis

  Physics Websites

Summary: brain magnetic resonance imaging (MRI) including magnetization transfer (MT) imaging at baseline and two testing included the Brief Repeatable Battery (BRB). Imaging parameters included lesion load, brain parenchyma fraction, ventricular fraction (VF), mean MT ratio (MTR) of lesion and normal appearing brain

Paris-Sud XI, Université de

249

Journal of Biomechanics 37 (2004) 12631269 Reassessment of brain elasticity for analysis of

  Mathematics Websites

Summary: Journal of Biomechanics 37 (2004) 1263­1269 Reassessment of brain elasticity for analysis-dimensional finite element model of the human brain/ventricular system is developed and analysed under hydrocephalic loading conditions. It is shown that the Young's modulus of the brain parenchyma used in previous studies

Frey, Pascal

250

Mutations in the Fatty Acid 2-Hydroxylase Gene Are Associated with Leukodystrophy

  Biology and Medicine Websites

Summary: with Spastic Paraparesis and Dystonia Simon Edvardson,1,2 Hiroko Hama,5 Avraham Shaag,1 John Moshe Gomori,3 spasticity, dystonia, cognitive dysfunction, and peri- ventricular white matter disease revealed inactivating. When they were 7­12 years of age, their spasticity extended to the upper limbs. Dystonia was evi- dent

Hsu, Yi-Te

251

Steven W. Day1 e-mail: sday@alumni.virginia.edu

  Environmental Sciences and Ecology Websites

Summary: of the time-varying flow in a centrifugal blood pump operating as a left ventricular assist device (LVAD, Charlottesville, VA 22903 PIV Measurements of Flow in a Centrifugal Blood Pump: Time-Varying Flow Measurements assist devices LVADs have proven clinical efficacy, but there are currently no devices capable

Day, Steven

252

Luca Gentili e-mail: l.gentili@unibo.it

  Engineering Websites

Summary: artificial heart: in particular, a magnetically levitated left ventricular assist device is studied failure. These complex mechatronic devices have benefited significantly from the methods of systems to a family of devices that include the total artificial hearts TAHs , which physically replace a patients

Paden, Brad

253

Innovators at Heart A publication for

  Environmental Sciences and Ecology Websites

Summary: Symposium gives physicians, researchers, and device-makers a cause for collaboration page 3 New energy that Loken did not have. So her doctors at the University of Minnesota Medical Center did the next best thing--they implanted into Loken's failing heart a ventricular assist device (VAD), which could keep blood pumping

Minnesota, University of

254

Three-dimensional computational prediction of cerebrospinal fluid flow in the human brain

  Engineering Websites

Summary: predicts the complex CSF flow patterns and pressures in the ventricular system and subarachnoid space of a normal subject. The predicted maximum rostral to caudal CSF flow in the pontine cistern precedes is in excellent agreement with the subject-specific flow data. The computational results quantify normal

Linninger, Andreas A.

255

1450 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 58, NO. 5, MAY 2011 Dynamic Brain Phantom for Intracranial

  Biology and Medicine Websites

Summary: of the ventricles are obtained from a normal subject and (right) patient with obstructive hydrocephalus with the MR--Knowledge of intracranial ventricular volume is im- portant for the treatment of hydrocephalus, a disease in which cere- brospinal fluid (CSF) accumulates in the brain. Current monitor- ing options involve MRI or pressure

Linninger, Andreas A.

256

July 2010 Volume 6, Number 1 www.thejns.org

  Engineering Websites

Summary: and ventricular volume growth in normal compared with hydrocephalic mice. Methods. Hydrocephalus was induced in 14 transmantle pressure gradients. These 2 patterns of hydrocephalus were significantly discriminable using of neuroimaging technology, shunt-valve design, and surgical techniques, outcomes in patients with hydrocephalus


257

MATHEMATICAL BIOSCIENCES 10.3934/mbe.20xx.xx.xx AND ENGINEERING

  Mathematics Websites

Summary: heart heavily relies on the coordination between several different excitable tissues. In normal network is isolated from the muscle except at its endpoints that are connected to the ventricular wall into account the microstructure of the tissue. In such a context the main issue is to properly write

Coudière, Yves

258

Regulated Nuclear Trafficking of the Homeodomain Protein Otx1 in Cortical Neurons

  Biology and Medicine Websites

Summary: Regulated Nuclear Trafficking of the Homeodomain Protein Otx1 in Cortical Neurons Y. Alex Zhang,1 in the rat ventricular zone, and remains cytoplasmic as neurons migrate and begin to differentiate. Nuclear, that the N-terminus of Otx1 is nec- essary for nuclear import, and that a putative nuclear localization

McConnell, Susan

259

September 2008 Volume 10, Number 9

  Biology and Medicine Websites

Summary: 1 pack per day. In the ED, he is pain free and has an ECG with evidence of left ventricular hypertro on the conservative side and admit him to your observation unit. The patient looks well, his first troponin is negative, and the monitor continues to show a normal sinus rhythm. Two hours later you go to check


260

Abstract--The purpose of this study is to investigate the potential of the ensemble empirical mode decomposition

  Biology and Medicine Websites

Summary: -invasively monitor left ventricular stroke volume by ECG triggered ensemble averaging and digital band-pass filtering to measure cardiac stroke volume. First, a simple cardio-respiratory model is used to simulate cardiac, which makes them less applicable for continuous monitoring. To avoid the risks associated

Fontecave-Jallon, Julie

261

A Possible Mechanism for Electrocardiographically Silent Changes in Cardiac Repolarization

  Engineering Websites

Summary: , Utah #12;Abstract Despite the widespread use of the ECG, changes in cardiac activity resulting from" or are first detectable using techniques that measures ventricular contractility such as ultrasound or blood pressure. Especially local changes in repolarization can go undetected when ECG electrodes do not lie close

MacLeod, Rob S.

262

> ID 990 < 1 Abstract--This paper demonstrates the first measurement of

  Biology and Medicine Websites

Summary: > ID 990 first measurement of the acoustoelectric (AE, such as the CARTOTM EAM system, are not able to monitor the cardiac activation wave in real-time, requiring many averages of the ECG and, consequently, not able to detect nonsustained arrhythmias (e.g., ventricular

Witte, Russell S.

263

IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 18, NO. 10, OCTOBER 1999 1025 Medial-Node Models to Identify and Measure

  Biology and Medicine Websites

Summary: is appropriate for real-time clinical use. Index Terms--Core atom, left ventricle, medial dimensionality, 3-D but worthwhile goals. Nowhere is this more evident than in the automated analysis of cardiac left ventricular (LV of a conventional linear array [Fig. 12(a)]. Because of the large number of 3-D im- ages produced every second by RT


264

Receptor tyrosine phosphatase zeta/beta in astrocyte progenitors in the developing chick spinal cord

  Biology and Medicine Websites

Summary: chick spinal cord. RPTPZ/b was expressed throughout the ventricular zone (VZ) of the developing spinal a single ,9 kbp RPTPZ/b transcript expressed in the embryonic chick spinal cord, indicating that the shorter alternative-splice products of RPTPZ/b found in rodent spinal cord and brain

Richardson, William D.

265

Volume Assessment of the Cerebrospinal Fluid Spaces for Computer Aided Diagnosis

  Physics Websites

Summary: with a topological assumption on the CSF shape. Experiments on phantoms and clinical data were performed people can be achieved by a linear discriminant analysis on volumes of the ventricular and intracranial these volumes. Keywords: cerebrospinal fluid, hydrocephalus, 3D segmentation, topology preservation, computer

Paris-Sud XI, Université de

266

Original article Calmodulin mutations associated with long QT syndrome prevent

  Computer Technologies and Information Sciences Websites

Summary: of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes Worawan B May 2014 Keywords: Calmodulin Ca2+ /CaM-dependent inactivation (CDI) L-type Ca2+ channel Long-QT syndrome APD prolongation Recent work has identified missense mutations in calmodulin (Ca

Niebur, Ernst

267

Progress in Biophysics and Molecular Biology, 69(2-3):333351, 1998. 1 Physical and Geometrical Modeling for

  Biology and Medicine Websites

Summary: being to use real data to guide recovery when possible, but use the model as a smart interpolator Modeling for Image-Based Recovery of Left Ventricular Deformation James Duncan, Ph.D., , Pengcheng Shi, Ph or otherwise corrupted image data. Often models are employed to help guide this recovery process, with the goal

Duncan, James S.

268

Mathematical Modeling of Flow-Generated Forces in an In Vitro System of Cardiac Valve Development

  Energy Storage, Conversion and Utilization Websites

Summary: leaflets. A longstanding hypothesis proposes that blood flow- generated shear stress and pressure model that simulates the forces created by blood flow present in a developing chick heart and in our leaflets, which function to prevent regurgitation of blood from the ventricular chamber back

Weidner, John W.

269

Elec 331 -Blood Pressure Heart Valves

  Energy Storage, Conversion and Utilization Websites

Summary: Elec 331 - Blood Pressure 1 Heart Valves · Atrio-Ventricular (AV) ­ Bicuspid / Mitral (left - Blood Pressure 2 Phases of the Heart · Systole (Max BP) ­ Ventricle contracted ­ Aorta inflated 331 - Blood Pressure 3 Korotkov Phases / Sounds S D P P Nothing Sharp Swish Faint Nothing 0 1 2-3 4 5

Pulfrey, David L.

270

Study of Pressure Estimation for a Human Circulatory System with a LVAD

  Engineering Websites

Summary: Study of Pressure Estimation for a Human Circulatory System with a LVAD Yi Wu1 , Paul Allaire2-- Physiological control of left ventricular assist de- vice (LVAD) can be related to the control of pressure. Based on the state space model of human circulatory system, the mean aortic pressure can be estimated

Wu, Yi

271

BIOGRAPHICAL SKETCH Skliar, Mikhail

  Engineering Websites

Summary: for Ventricular Assist Devices," Artificial Organs, 26:980-984, 2002. 5. D. Arora, M. Skliar, R. B. Roemer, "Model Conference, 1990; M.S.E.E. with Highest Honors, Odessa Technical University, 1986. B. Selected peer, M. Skliar, D. B. Olsen and G. M. Pantalos, Modeling and Control of Brushless DC Axial Flow

Skliar, Mikhail

272

Am. J. Hum. Genet. 69:13781384, 2001 A Missense Mutation in a Highly Conserved Region of CASQ2 Is

  Biology and Medicine Websites

Summary: , Israel Catecholamine-induced polymorphic ventricular tachycardia (PVT) is characterized by episodes of the autosomal recessive form. The CASQ2 protein serves as the major Ca2+ reservoir within the SR of cardiac. (1995). The disease is characterized by a reproducible form of ven- tricular tachycardia, inducible

Lancet, Doron

273

Artificial Organs 29(5):378386, Blackwell Publishing, Inc.

  Biology and Medicine Websites

Summary: --Thrombus deposition--Wall shear rates. Penn State's 70cc pneumatic left ventricular assist device (LVAD) has been.S.A. Abstract: Particle image velocimetry is used to study the flow field associated with off-design conditions wall washing at higher beat rates and shorter dias- tolic time. A flow separation near the minor

Manning, Keefe B.

274

Running title: Amiodarone-induced PRR prevents VF Correspondence address:

  CiteSeer

Summary: Number of text pages: 14 (19 including reference list) Number of tables: 1 Number of figures: 5 Number of references: 39 Number of words abstract: 239 introduction: 421 discussion: 1553 Abbreviations: APD action potential duration ECG electrocardiogram ERP effective refractory period MAP monophasic action potential mVT monomorphic ventricular tachycardia PRR post-repolarization refractoriness

Paulus Kirchhof Md; Hubertus Degen Bs; Lars Eckardt; Günter Breithardt; Md Fesc Facc; Wilhelm Haverkamp; Paulus Kirchhof Md

275

Enro.sagepub.com ISSN: 1073-8584

  Biology and Medicine Websites

Summary: of as a transient substrate for neuron migration in the developing brain. In fact, RG cells, far from exclusively came further support for the idea of RG as a scaffold for neuronal migration from the ventricular zone zone to the upper cortical layers (Rakic 1972; Sidman and Rakic 1973). The apparent postnatal

Ruthazer, Edward

276

Neurobiology of Disease Presenilin-1 Regulates Neural Progenitor Cell Differentiation

  Biology and Medicine Websites

Summary: -expressing short interfering RNA (siRNA) for the exclusive knockdown of PS1 in the neurogenic microenviron- ments- crete microenvironments, the subventricular zone (SVZ) and the subgranular layer (SGL) of the dentate at embryonic day 14.5 the ventricular zone is substantially thinner, indicating a drastic reduction

Alford, Simon

277

Fractal Analysis of Heart Rate Dynamics as a Predictor of Mortality in Patients

  Biology and Medicine Websites

Summary: Fractal Analysis of Heart Rate Dynamics as a Predictor of Mortality in Patients With Depressed Left stratification has not been evaluated. This study was designed to determine whether selected new dy- namic analysis methods of HR variability predict mor- tality in patients with depressed left ventricular (LV


278

Intensive Care Med . Author manuscript Impact of acute hypercapnia and augmented positive end-expiratory

  Physics Websites

Summary: positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome) in patients with severe acute respiratory distress syndrome (ARDS) on right (R) and left ventricular (LV) with compensation of the tidal volume reduction by either a high respiratory rate (high2 2 PEEP/high rate

Paris-Sud XI, Université de

279

Journal of Computational Neuroscience 4, 207219 (1997) c 1997 Kluwer Academic Publishers. Manufactured in The Netherlands.

  Biology and Medicine Websites

Summary: of Biological Sciences, Ohio University, Athens, OH 45701 Hooper@ohiou.edu Received August 14, 1996; Revised by the pacemaker burst beginning. However, in this reference frame certain pattern elements maintain phase better intermediate maintenance with each group. If ventricular dilator neuron burst beginning (VDB) is chosen

Hooper, Scott

280

Copyright by ICR Publishers 2012 Background and aim of the study: The study aim was

  Biology and Medicine Websites

Summary: the saddle annulus motion of the mitral valve was developed. A series of computational analyses and in that the interaction between the leaflet and the ventricular results in fundamentally distinct transmitral vortex formation patterns. Conclusion: Motion of the mitral saddle annulus along with the leaflet length

Kheradvar, Arash

281

Statistically Constrained Snake Deformations Ghassan Hamarneh and Tomas Gustavsson

  Biology and Medicine Websites

Summary: of significant shape variation modes, explaining most of the shape variation in the training set. Armed visible in the image. This is clearly the case in heart images obtained by ultrasonography which similar to PDM for capturing the main modes of ventricular shape variation, however, in our method shapes

Hamarneh, Ghassan

282

CARDIOTHORACIC ANESTHESIOLOGY: The Annals of Thoracic Surgery CME Program is located online at http://cme.ctsnetjournals.org.

  Computer Technologies and Information Sciences Websites

Summary: with multivariate statistical analy- sis. Expert knowledge was derived from interviews of 11 members of ventricular assist devices (VADs) for treat- ment of end-stage heart failure has steadily in- creased during of myocardial function of VAD pa- tients suggest that chronic unloading of the native heart can lead to reverse

Druzdzel, Marek J.

283

Visualization of embryonic neural stem cells using Hes promoters in transgenic mice

  Biology and Medicine Websites

Summary: Visualization of embryonic neural stem cells using Hes promoters in transgenic mice Toshiyuki stem cells proliferate in the ventricular zone (VZ) and sequentially give rise to both neurons and glial cells in a temporally and spatially regulated manner, suggesting that stem cells may differ from

McConnell, Susan

284

Importing Ontologies with Hidden Content Bernardo Cuenca Grau and Boris Motik

  Computer Technologies and Information Sciences Websites

Summary: ontologies are used, for example, in several countries to describe electronic patient records (EPR). Patients, an EPR application should preferably reuse these reference ontologies. For example, assume that a reference ontology Kh describes concepts such as the "ventricular septum defect." An EPR appli- cation might

Grau, Bernardo Cuenca

285

Import-by-Query: Ontology Reasoning under Access Limitations Bernardo Cuenca Grau, Boris Motik, and Yevgeny Kazakov

  Computer Technologies and Information Sciences Websites

Summary: (EPR). In such a system, patients' data typically involves ontological descriptions of human anatomy interoperability between applica- tions, and rely on experts' knowledge, an EPR application should preferably reuse such as the "ventricular septum defect." An EPR application might reuse the concepts and roles from Kh to define its own

Grau, Bernardo Cuenca

286

Titin isoform switching is a major cardiac adaptive response in hibernating Grizzly Bears

  CiteSeer

Summary: Copyright © 2008 by the American Physiological Society. Cardiac titin isoform switching in hibernating bears 2 The hibernation phenomenon captures biological as well as clinical interests to understand how organs adapt. Here we studied how hibernating grizzly bears (Ursus arctos horribilis) tolerate extremely low heart rates without developing cardiac chamber dilation. We evaluated cardiac filling function in unanesthetized grizzly bears by echocardiography during the active and hibernating period. Because both collagen and titin are involved in altering diastolic function, we investigated both in the myocardium of active and hibernating grizzly bears. Heart rates were reduced from 84 bpm in active bears to 19 bpm in hibernating bears. Diastolic volume, stroke volume and left ventricular ejection fraction were not different. However, left ventricular muscle mass was significantly lower in the hibernating bears 300 ± 12 compared to 402 ± 14 grams (p = 0.003), and as a result the diastolic volume to left ventricular muscle mass ratio was significantly greater. Early ventricular filling deceleration times were shorter during hibernation, 106.4 ± 14 compared to 143.2 ± 20 ms (p = 0.002) suggesting

O. Lynne Nelson; Charles T. Robbins; Yiming Wu; Henk Granzier

287

Micro-Force Sensor by Active Control of a Comb-Drive Abdenbi Mohand Ousaid, Sinan Haliyo, Stephane Regnier and Vincent Hayward

  Engineering Websites

Summary: by measuring both pull-in and pull-off forces during an approach-retract cycle on water droplet. Both phenomena, although differing by an order of magnitude in amplitude, are correctly assessed. I. INTRODUCTIONN range from isolated ventricular heart cells (cardiac myocytes) differs in normal or diseased heart [1

Hayward, Vincent

288

Revised BC-990037 1 LOCALIZATION OF K

  Physics Websites

Summary: -tubules over few days in culture, which causes the loss of about 60% of the cell membrane capacitance (Cm of the electrical activity of cardiac ventricular muscle (for a review: Carmeliet, 1993). The background inward in extracellular spaces, either in the physiological state or in pathological states. In skeletal muscle

Paris-Sud XI, Université de

289

RICERCA SCIENTIFICA 2013 ELENCO FINANZIATI PROGETTI AWARDS COGNOME Nome MA TITOLO FIN. ATTRIB.

  Physics Websites

Summary: device (LVAD) and autologous stem cell combined therapy 60.000 Santoni angela B MOLECULAR MECHANISMS in Diabetes 60.000 Gulino Alberto B Targeting Hedgehog pathway to control brain cancer stem cells 60. Biondi Zoccai Giuseppe B New insights in cardiac regeneration: breakthrough in left ventricular assist

Guidoni, Leonardo

290

RICERCA SCIENTIFICA 2013 GRADUATORIA PROGETTI AWARDS COGNOME Nome MA TITOLO FIN. ATTRIB.

  Physics Websites

Summary: (LVAD) and autologous stem cell combined therapy 60.000 Santoni angela B MOLECULAR MECHANISMS REGULATING in Diabetes 60.000 Gulino Alberto B Targeting Hedgehog pathway to control brain cancer stem cells 60 Zoccai Giuseppe B New insights in cardiac regeneration: breakthrough in left ventricular assist device

Guidoni, Leonardo

291

Influence of a constriction in the near field of the vocal folds: Physical modeling and experimental validation

  Computer Technologies and Information Sciences Websites

Summary: impact of the ventricular folds on the pressure distribution and thereby on the vocal-fold vibrations. The mechanical behavior of the vocal folds is simulated by a distributed model accounting for this impact properties high viscosity and low stiffness are different from those of biomechanical oscillators

Boyer, Edmond

292

MATHEMATICAL BIOSCIENCES doi:10.3934/mbe.2009.xx.xx AND ENGINEERING

  Mathematics Websites

Summary: of thrombus formation. A novel FSI algorithm was developed to deal with the presence of multiple structures simulations based on a fluid-structure interaction solver to investigate formation of stagnation points OF LEFT VENTRICULAR ASSIST DEVICE Annalisa Quaini Department of Mathematics, University of Houston 4800

Canic, Suncica

293

Reaction-Diffusion systems for the macroscopic Bidomain model of the cardiac electric field

  Mathematics Websites

Summary: Reaction-Diffusion systems for the macroscopic Bidomain model of the cardiac electric field Marco Veneroni Abstract. The paper deals with a mathematical model for the electric activity of the heart models of the electric activity of cardiac ventricular cells, at macroscopic level. The models we analyze

Veneroni, Marco

294

Dynamic Deformable Models for 3D MRI Heart Segmentation

  Computer Technologies and Information Sciences Websites

Summary: and reproducibility to 2D-echocardiography without the ionizing radiation needed by computed to- mography. Typically of ventricular mass and function are important in myocardial diseases, such as coronary artery disease, myocarditis, and cardiomyopathy, as well as systemic diseases such as hypertension, diabetes, and cancer

Breen, David E.

295

Xiaopeng Zhao1 Department of Biomedical Engineering,

  Physics Websites

Summary: of future models. DOI: 10.1115/1.2960467 1 Introduction 1.1 Background. Cardiovascular disease is the number that is often initiated by ventricular fibrillation, a fatal heart rhythm disorder. The induction and main arrhythmias and developing therapies for preventing sudden cardiac death. To develop an understanding

Gauthier, Daniel

296

MRI predictors of cognitive outcome in early multiple sclerosis Mathilde S.A. Deloire1,2

  Physics Websites

Summary: Deloire 1 MRI predictors of cognitive outcome in early multiple sclerosis Mathilde S.A. Deloire1 tables. Keywords: Multiple sclerosis, Brain atrophy, Ventricular fraction, Cognition, Magnetic resonance for cognitive outcome in early relapsing remitting multiple sclerosis (MS) patients. Methods: Inception Cohort

Paris-Sud XI, Université de

297

S03015629(99)000599 Original Contribution

  Mathematics Websites

Summary: S0301­5629(99)00059­9 Original Contribution ARTIFICIAL NEURAL NETWORKS AND SPATIAL TEMPORAL CONTOUR October in 8 April 1999) Abstract---This study investigated artificial neural networks (ANN) image artificial neural networks spatial temporal contour linking allows accurate calculations ventricular areas

Strohmer, Thomas

298

Circulation . Author manuscript H11 kinase/heat shock protein 22 deletion impairs both nuclear and

  Physics Websites

Summary: nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac function of Hsp22 in that context, a knockout (KO) mouse model of Hsp22 deletion was generated. Although hypertrophy, and showed ventricular dilation, impaired contractile function, increased myocyte length

Paris-Sud XI, Université de

299

Cardiovasc Res . Author manuscript Jerome Piquereau

  Physics Websites

Summary: In mutant mice, cardiac function assessed by echocardiography was not significantly different from; unexpectedly, mitochondria were largerOpa1 with the presence of clusters of fused mitochondria and altered cristae. In permeabilized mutant ventricular fibers, mitochondrial functional properties were maintained

Paris-Sud XI, Université de

300

Interleukin-18 Is a Pro-hypertrophic Cytokine That Acts through a Phosphatidylinositol 3-Kinase-Phosphoinositide-dependent Kinase-

  Biology and Medicine Websites

Summary: IL-18 effects revealed that IL-18 activates phosphoinositide 3-kinase (PI3K), an effect gene transcription via PI3K, PDK1, Akt, and GATA4. Most importantly, IL-18 induced ANF gene transcription and hypertrophy of neonatal rat ventricular myocytes via PI3K-, Akt-, and GATA4- dependent

Wojcik, Edward J.

301

154 Am J Psychiatry 161:1, January 2004http://ajp.psychiatryonline.org Brief Report

  Biology and Medicine Websites

Summary: volume loss. Method: High-resolution magnetic resonance imaging scans from 39 patients with schizophrenia brain imaging abnormali- ties found in schizophrenia, as well as one of the most sta- ble findings of certain parts of the ventricular system, such as the tempo- ral horn or body of the ventricles (2

Gaser, Christian

302

Fax +41 61 306 12 34 E-Mail karger@karger.ch

  Biology and Medicine Websites

Summary: ;73:26­42 DOI: 10.1159/000202988 Pyloric Neuron Morphology in the Stomatogastric Ganglion of the Lobster microscopy Crustacea Alexa dyes Stomatogastric Panulirus Morphology Lobster Abstract The pyloric network stomatogastric ganglion stn stomatogastric nerve VD ventricular dilator (neuron) #12;Lobster (Panulirus) Pyloric

Hooper, Scott

303

Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells

  Biology and Medicine Websites

Summary: tube-derived structures, the cells abutting the luminal side of the optic cup form a ventricular zone Cells Xianjie Yang and Constance L. Cepko Howard Hughes Medical Institute and Department of Genetics, progenitor cells are multipotential, producing a variety of distinctive cell types. Little is known

Tabin, Cliff

304

Contrast

  CiteSeer

Summary: Cardiac metastases of thyroid carcinomas are rarely diagnosed ante mortem and infrequently reported in the literature. A 68-year-old man with known papillary thyroid carcinoma presented to the hospital with progressive shortness of breath. A transthoracic echocardiogram revealed a right ventricular mass. Contrast echocardiography perfusion imaging was used to evaluate the vascularity of the mass.

Sherif E. Moustafa; Robert Amyot
2007-01-01

305

Efficient Modeling of Excitable Cells Using Hybrid Automata

  Computer Technologies and Information Sciences Websites

Summary: biological systems. Our goal is to efficiently capture the behavior of excitable cells previously modeledEfficient Modeling of Excitable Cells Using Hybrid Automata Pei Ye1 , Emilia Entcheva2 , Radu Grosu-Huxley model of the giant squid axon, the Luo-Rudy dynamic model of a guinea pig ventricular cell, and a model

Grosu, Radu

306

RESEARCH Open Access Impact of routine percutaneous coronary

  Physics Websites

Summary: to ventricular fibrillation. The aim of our study was to evaluate the prognostic impact of routine PCI]. Recently, mild therapeutic hypothermia (MTH) has been reported to improve neurological outcomes in patients associated with MTH treatment in patients with OHCA and ST-segment elevation may improve survival [6]. Sunde

Paris-Sud XI, Université de

307

Cell Transplantation, Vol. 18, pp. 297304, 2009 0963-6897/09 $90.00 + .00 Printed in the USA. All rights reserved. E-ISSN 1555-3892

  Chemistry Websites

Summary: develops, and results in congestive heart failure in more than 500,000 patients in the US each year. Muscle significant therapeutic implications. Early studies in patients with chronic ischemic systolic left in left ventricular ejection function (LVEF) and clinical status, without notable safety issues. Nonethe

Linhardt, Robert J.

308

Automatic computation of CHA2DS2-VASc score: Information extraction from clinical texts

  Computer Technologies and Information Sciences Websites

Summary: in the final score: (i) Congestive heart failure or left ventricular dysfunction, 1 pt, (ii) Hypertension, 1 pt for a patient, for instance their smoking status,[6] obesity status,[7] or the presence of a congestive heart failure (CHF).[8,9] Such information is useful for a variety of applications such as triggering alerts

Zweigenbaum, Pierre

309

JOURNAL OF EXPERIMENTAL ZOOLOGY 290:751758 (2001) 2001 WILEY-LISS, INC.

  Environmental Sciences and Ecology Websites

Summary: contains only one form. Again, in trout, there was no change in the white muscle protein composition at PST different proteins contribute to the machinery of muscle contraction, but the myosin heavy chain protein Expression in the Red, White, and Ventricular Muscle of Juvenile Stages of Rainbow Trout FRANCES E. WEAVER

Coughlin, David J.

310

ISSN: 1524-4571 Copyright 2008 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online

  Materials Science Websites

Summary: muscle myocytes. We engineered the shape of neonatal rat ventricular myocytes by culturing them of contraction could be dis- tinctly engineered. These data suggest that physical con- strainment of muscle cells such as translation or signal- ing pathways contribute to regulation of muscle growth during cardiac organo

Parker, Kevin Kit

311

THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 269, No. 45, Issue of November 11, pp. 28359-28365, 1994 1994 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A.

  Biology and Medicine Websites

Summary: Characterization and Ultrastructural Localization of a Novel 90-kDa Protein Unique to Skeletal Muscle Junctional skeletal muscle. Biochemical experiments show that the 90 kDa protein is an integral membrane protein to the 90 kDa protein was not detected in ventricular myocytes or vascular smooth muscle cells

Campbell, Kevin P.

312

STANFORD UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF VETERANS AFFAIRS MEDICAL CENTER

  Biology and Medicine Websites

Summary: , and ventricular dysfunction. · The trainee should understand the role of risk factor modification (hypertension, and post CABG regarding risk factor modification. At the start of the rotation, the fellow is given of the risk factors, prevention of, detection, and treatment of coronary allograft vasculopathy. Skills

Ford, James

313

VA Inpatient Rotation Objectives The trainee should have an understanding of the pre-operative, anesthetic,

  Biology and Medicine Websites

Summary: output states, and ventricular dysfunction. · The trainee should undersand the role of risk factor an understanding of the risk factors, prevention of, detection, and treatment of coronary allograft vasculopathy modification (hypertension, dyslipidemia, diabetes, exercise, smoking cessation) in the secondary prevention

Ford, James

314

12/01/2011 Article 1 1/23 Influence of blood glucose on heart rate and cardiac autonomic function.

  Physics Websites

Summary: classes. Spearman correlation coefficients quantified the relations between cardio-metabolic risk factors is the result of fitness, neurohormonal factors and the autonomic nervous system function. In type 2 diabetic recovery from hypoglycaemic episodes, hypertension [12], nephropathy [9], and changes in ventricular

Paris-Sud XI, Université de

315

velocity probe andits evaluation," Cardiovascular Res., vol. 1, p. 263, 1967.

  Engineering Websites

Summary: , p. 403, 1967. velocity probe-A new instrument," Amer. J. Cardiol.,vol. 23, p. Babitt, "Physiologic evaluation of a catheter tip electromagnetic I[ 171 J. Rosborough and B. Stogdill, Dept. of Physiology ventricular ejection dynamics in man during rest and exercise,"American Heart Association Mono- (21] D.L. Fry

Mitter, Sanjoy K.

316

Exercise Physiology Ethnic Differences in Physiological Cardiac Adaptation to

  Computer Technologies and Information Sciences Websites

Summary: Exercise Physiology Ethnic Differences in Physiological Cardiac Adaptation to Intense Physical Exercise in Highly Trained Female Athletes J. Rawlins, MRCP; F. Carre, PhD; G. Kervio, PhD; M. Papadakis exercise in black female athletes is associated with greater left ventricular hypertrophy and higher

Boyer, Edmond

317

Cardiac Motion Analysis Based on Optical Flow on Real-Time Three-Dimensional Ultrasound Data

  Biology and Medicine Websites

Summary: tracking of the left ventricular endocardial border. Due to the large size of the volumetric data sets, manual tracing of the endocardial border is tedious and impractical for clinical applications. Therefore to follow the endocardial border in three dimensional ultrasound data through time. The four


318

Brain Mapping as a Tool to Study Neurodegeneration Liana G. Apostolova and Paul M. Thompson

  Biology and Medicine Websites

Summary: cognitively impaired, in partic- ular, are at a fivefold increased risk of imminent conversion to dementia, and automated methods for map- ping ventricular anatomy. Applications to AD and other dementias are discussed, dementia, mild cognitive impairment, Alzheimer's disease, schizophrenia, de- pression, human brain

Thompson, Paul

319

Engineering AspectsComputational Studies Coupling Pediatric Ventricle Assist Devices to the Fontan

  Biology and Medicine Websites

Summary: Engineering Aspects­Computational Studies Coupling Pediatric Ventricle Assist Devices to the Fontan,* CAROL W. LUCAS, W. JAMES PARKS, AND AJIT P. YOGANATHAN* In pediatric ventricular assist device (VAD that create elevated systemic venous pressure and altered pulmo- nary hemodynamics. Substituting a mechanical

Pekkan, Kerem

320

material properties and valve geometry) and extrinsic forces (e.g. due to blood viscosity and external forces).

  Biology and Medicine Websites

Summary: of the valve and the atrial and ventricular compliance. Because there are many non-linear parameters involved motion Á Endoscopy Á Laparoscopy Purpose This paper presents a study of abdominal organ shift due imaging in guiding endoscopic interventions. CT and MRI images of the torso are conventionally made


321

Universittsmedizin Gttingen Publikationen und Hochschulschriften 2009

  Biology and Medicine Websites

Summary: (2009) [Developments in modern oncology. Ramifications for anesthesia and intensive care medicine, Schmitto JD, Bockhorst K, Stich KM, Koerfer R (2009) Experiences with surgical treatment of ventricle, Coskun ST, Hinz J, Schmitto JD, Körfer R (2009) Surgical treatment of left ventricular aneurysm. Asian

Gollisch, Tim

322

Analysis of Cardiac Motion with Recursive Comb Filtering John C. McEachen II y , Arye Nehorai y , and James S. Duncan y;z

  Biology and Medicine Websites

Summary: Yale University New Haven, CT 06520­8042 ABSTRACT A framework for temporal analysis of left ventricular filtering to model the periodic nature of cardiac motion. A method for flow vector computation is presented contours and surfaces in images. Within computer vision, considerable attention has been given in recent

Duncan, James S.

323

J. theor. Biol. (1990) 146, 407-432 Chaotic Dynamics in an Ionic Model of the Propagated Cardiac

  Biology and Medicine Websites

Summary: of ventricular muscle by numerically integrating the one-dimensionalcable equation using the Beeler-Reuter model the response of the strand to premature stimulation. This involves deriving a one-dimensional finite of iteration of the map and the results of the numerical integration of the cable equation. Calculation

Guevara, Michael R.

324

Original Research Measuring Human Cardiac Tissue Sodium

  Biology and Medicine Websites

Summary: was 43 4, 53 12, and 17 4 mol/g in the left ventricular (LV) free wall, septum, and adipose tissue, re, Adiabatic Excitation, and Twisted Projection Imaging With Minimal T2 Losses Ronald Ouwerkerk, PhD,1* Robert G. Weiss, MD,2 and Paul A. Bottomley, PhD1 Purpose: To measure tissue sodium concentrations

Ouwerkerk, Ronald

325

IEEE TRANSACTIONS ON IMAGE PROCESSING, VOL. 9, NO. 4, APRIL 2000 651 Multiframe Temporal Estimation of Cardiac Nonrigid

  Engineering Websites

Summary: of Cardiac Nonrigid Motion John C. McEachen, II, Member, IEEE, Arye Nehorai, Fellow, IEEE, and James S motion of the left ventricular (LV) endocardial wall in image sequences has been developed. This system is unique in its ability to model motion trajectories across multiple frames. The foundation of this system

Nehorai, Arye

326

289:398-413, 2005. First published Feb 11, 2005; doi:10.1152/ajpheart.00683.2004AJP -Heart Brigitte Pelzmann, Bernd Koidl and Michael R. Guevara

  Biology and Medicine Websites

Summary: , and Ba2 . Electrical activity in small clusters is very different from that in reaggregates of several hundred embryonic chick ventricular cells, e.g., TTX-sensitive fast upstrokes in reaggre- gates vs. TTX-insensitive slow upstrokes in small clusters (maximum upstroke velocity 100 V/s vs. 10 V/s). On the basis of our

Guevara, Michael R.

327

Follower Neurons in Lobster (Panulirus interruptus) Pyloric Network Regulate Pacemaker Period in Complementary Ways

  Biology and Medicine Websites

Summary: and the Ventricular Dilator (VD) neuron by electrical coupling. LP and VD neuron effects on pyloric cycle period can- tions in cycle period (e.g., fast vs. slow breathing) and pattern phasing (e.g., breathing vs. gasping, the pacemaker is electrically coupled to other net- work neurons to form a synchronously firing pacemaker en

Hooper, Scott

328

Apical Ballooning Syndrome: A Complication of Dual Chamber Pacemaker Implantation

  CiteSeer

Summary: mglikson/at/post.tau.ac.il Apical ballooning is a cardiac syndrome (Takotsubo Cardiomyopathy) described as a typical form of acute transient left ventricular dysfunction. While its onset has often been associated with emotionally or physically stressful situations, it has an overall favorable prognosis. We describe here a case of transient apical ballooning following permanent pacemaker implantation.

unknown authors

329

Recovery of Soft Tissue Object Deformation from 3D Image Sequences using Biomechanical Models

  Biology and Medicine Websites

Summary: equations are discretized and solved using the finite element method. We demonstrate the application estimates as described in section 4. The general problem is solved using the finite-element method (section of this method to estimating strains from sequences of in- vivo left ventricular MR images, where we incorporate

Duncan, James S.

330

Development/Plasticity/Repair Loss of X-Linked Mental Retardation Gene Oligophrenin1 in

  Physics Websites

Summary: Development/Plasticity/Repair Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar words: X-linked mental retardation; ophn1 knock-out; dendritic spines; brain ventricular enlargement

Paris-Sud XI, Université de

331

Dynamics of pure parasystole LEON GLASS, ARY L. GOLDBERGER, AND JACQUES BELAIR

  Biology and Medicine Websites

Summary: Specifically, for any set of fixed values for the sinus and ectopic frequencies and the ventricular refractory and only one of these values is odd, and the sum of the two smaller values is one less than the larger beats at a fixed rate. Because of entrance block, this automatic focus is not affected by the normal

Glass, Leon

332

Y1102. The probability of bursting was not affected by Y1102. Instead, Y1102 increased

  Environmental Sciences and Ecology Websites

Summary: medications and hypokalemia, our computa- tions predicted that Y1102 would induce ac- tion potential prolongation and early afterde- polarizations (EADs). EADs are a cellular trigger for ventricular tachycardia and/or induce torsade de pointes can be found at www.torsades.org. 20. S. J. Compton et al

Brodie III, Edmund D.

333

Absence of the Transcription Factor Nfib Delays the Formation of the Basilar Pontine and Other Mossy

  Biology and Medicine Websites

Summary: of different family mem- bers (Kruse and Sippel, 1994; Chaudhry et al., 1998). In vivo, Nfi mRNAs are expressed in overlapping but specific patterns in multiple organs throughout the body (Chaudhry et al., 1997), suggesting are highly expressed in ventricular zones (Chaudhry et al., 1997; Deneen et al., 2006; Plachez et al., 2008

Gronostajski, Richard M.

334

Annu. Rev. Physiol. 1999. 61:57392 Copyright c 1999 by Annual Reviews. All rights reserved

  Biology and Medicine Websites

Summary: the river systems to hypoxic pools, natural selection favored animals that could breathe air as well: evolution, air-breathing fishes, myocardial hypoxia, ventricular septum, coronary circulation ABSTRACT in hypoxic water. This view overlooks the possibility that lungs may have functioned to supply the heart

Paiva, Paulo Cesar de

335

CCaarrddiioovvaassccuullaarr RReesseeaarrcchh PPrrooppoossaall OOppppoorrttuunniittiieess MMaayy 22001111

  Biology and Medicine Websites

Summary: disease. External Deadline: 10/11/11 Internal Deadline: 09/27/11 Pulmonary Vascular-Right Ventricular Axis of the molecular determinants contributing to cardiovascular and lung disease phenotypes to help in predicting disease susceptibility, diagnosis, risk stratification, assessing response to therapy and assessing

Thomas, David D.

336

ORIGINAL RESEARCH ARTICLE published: 11 December 2013

  Engineering Websites

Summary: as disease progressed, with approximately 130% increase in pulmonary resistance, 70% decrease in unstressed of cardiovascular dynamics in pulmonary hypertensive C57BL6/J mice Shivendra G. Tewari1 , Scott M. Bugenhagen1Su) to induce pulmonary hypertension. Data on right ventricular pressure and volume, and systemic arterial

Chesler, Naomi C.

337

Ion Channel Basis for Alternans and Memory in Cardiac Myocytes MINGYI LI and NIELS F. OTANI

  Biology and Medicine Websites

Summary: as electrical alternans .4,7,15,19,20,28,33 There is also considerable evidence suggesting that T wave alternansIon Channel Basis for Alternans and Memory in Cardiac Myocytes MINGYI LI and NIELS F. OTANI alternans in individual cardiac cells may be important in the development of ventricular tachycardia

Otani, Niels F.

338

The Journal of Neuroscience, November 1988, 8(11): 4400-4410 Korsakoff's Syndrome: Radiological

  Biology and Medicine Websites

Summary: - mography (CT) scans from 7 patients with Korsakoff's syn- drome, 7age-matched alcoholic subjects, and 7age brain areas. Tissue density was assessed by averaging CT values in small (5 x 5 mm) areas sampled algorithm that estimated the proportion of fluid in 7 brain regions-total ventricular space, third ven

Shimamura, Arthur P.

339

Atrioventricular Delay Optimization in Cardiac Resynchronization Therapy Assessed by a Computer Model

  Computer Technologies and Information Sciences Websites

Summary: -ventricular pacemaker (CRT-P). The model of the cardiac electrical activity is based on previous work [3] and has been and three stimulation inputs coming from the pacemaker (Stim.A, Stim.RV and Stim.LV ) simulat- ing the three to the corre- sponding chamber of the mechanical model and eventually sent to the pacemaker model

Boyer, Edmond

340

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

  CERN Preprints

Summary: We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

Moskvin, A S; Solovyova, O E; Markhasin, V S
2011-01-01

341

Electron-conformational transformations in nanoscopic RyR channels govern both the heart's contraction and beating

  Condensed Matter (arXiv)

Summary: We show that a simple biophysically based electron-conformational model of RyR channel is able to explain and describe on equal footing the oscillatory regime of the heart's cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca$^{2+}$ SR overload.

A. S. Moskvin; A. M. Ryvkin; O. E. Solovyova; V. S. Markhasin
2011-03-31

342

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research

  Biology and Medicine Websites

Summary: , *, The Alzheimer's Disease Neuroimaging Initiative a Laboratory of Neuro Imaging, Department of Neurology, UCLA; accepted 1 May 2010 Abstract Ideal biomarkers of Alzheimer's disease (AD) should correlate with accepted, gender, and educational level. In statistical maps ranked by effect sizes, ventricular differences were

Thompson, Paul

343

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation

  Chemistry Websites

Summary: , Harald Mikkers1,3 & Jonas Frise´n1 Targeted ectopic expression of genes in the adult brain niches without detectable brain damage. Injection of plasmid DNA into the ventricular system or directly electroporation provides a new approach to study the adult brain. The development of transgenic animal technology1

Cai, Long

344

Cell-autonomous and cell-to-cell signalling events in normal and altered neuronal migration

  Biology and Medicine Websites

Summary: in the pallial ventricular zone (VZ) and migrate radially to reach the cortical plate (Kriegstein & Noctor, 2004 destination in the cortical plate (Ang et al., 2003). If the direction of migration differs, the migratory the intermediate zone and change their morphology from a multipolar to a bipolar shape (Nadarajah & Parnavelas

Cossart, Rosa

345

Genetic Mosaic Dissection of Lis1 and Ndel1 in Neuronal Migration

  Biology and Medicine Websites

Summary: )-mediated neurogenesis, newborn migrating cortical projection neurons are bipolar-shaped in the ventricular zone (VZ zone (IZ). A switch from the multipolar state back to a bipolar morphology precedes radial glia-guided locomotion of projec- tion neurons toward the cortical plate (CP), with the trailing process concomitantly

Luo, Liqun

346

Int. J. Comput. Intelligence in Bioinformatics and Systems Biology, Vol. X, No. Y, xxxx 1 Copyright 200x Inderscience Enterprises Ltd.

  Computer Technologies and Information Sciences Websites

Summary: is a Postgraduate Research Student and PhD candidate in the Faculty of Engineering and Computer Science © 200x Inderscience Enterprises Ltd. Automatic brain MRI segmentation scheme based on feature weighting clustering method and apply it to brain magnetic resonance imaging (MRI) lateral ventricular compartments

Bargiela, Andrzej

347

An Electro-mechanical Model of the Heart for Cardiac Image Analysis

  Mathematics Websites

Summary: elasticity and, from the electrical point of view, on the finite-element discretisation of the FitzHugh-Nagumo electric wave-propagation model. Present simulations include static image segmentation. By including bi fraction, myocardium thickness and local strain and stress constitute the ventricular car- diac function

Coudière, Yves

348

Sedmera Vvoj komorovho myokardu Funkce orgnu je podmnna jeho strukturou. Toto tvrzen nabv zvlstn vznam u srdce, jez je jednm

  Computer Technologies and Information Sciences Websites

Summary: development, and during its morphogenesis must support the circulatory demands of the growing organism in the adult heart. Ventricular conduction system serves above all the coordinated spread of electrical and functional deployment of the various components of cardiac conuction system in the chick embryo, including

Tebbens, Jurjen Duintjer

349

doi:10.1152/ajpheart.01400.2007 294:1753-1766, 2008. First published Feb 8, 2008;Am J Physiol Heart Circ Physiol

  Engineering Websites

Summary: -duration ventricular fibrillation in dogs Chemical ablation of the Purkinje system causes early termination://ajpheart.physiology.org/cgi/content/full/294/4/H1753 can be found at:AJP - Heart and Circulatory PhysiologyaboutAdditional material of the heart, blood vessels, andAJP - Heart and Circulatory Physiology onOctober26,2008ajpheart

MacLeod, Rob S.

350

RESEARCH Open Access The subxiphoid view cannot replace the apical

  Physics Websites

Summary: .6 versus 7.6 ± 4 cm, respectively, P = 0.001 for both). Conclusions: An adequate TTE subxiphoid window an apical window: left ventricular ejection fraction (LVEF) [6,7], ratio between early and late mitral to assess whether use of the subxiphoid acoustic window in transthoracic echocardiography (TTE) can

Paris-Sud XI, Université de

351

Schizophrenia Research, 5 (1991) 1033113 SCHIZO 00172

  Biology and Medicine Websites

Summary: Schizophrenia Research, 5 (1991) 1033113 Elsevier 103 SCHIZO 00172 Application of automated MRI correlated with thought disorder. Key words: Magnetic resonance imaging; Ventricular volume; Magnetic studies in schizophrenia (e.g., Besson et al., 1987; Kelsoe et al., 1988; Andreasen et al., 1990; Suddath


352

Although it is well known that fish increase cardiac output (Q) during exercise to meet increased metabolic demands,

  Environmental Sciences and Ecology Websites

Summary: 1927 Although it is well known that fish increase cardiac output (Q) during exercise to meet, cardiac output, exercise, heart rate, mean circulatory filling pressure, prazosin, sea bass, stroke volume.e., cardiac preload (= central venous pressure, PCV). Ventricular end-systolic volume, at least in rainbow

Farrell, Anthony P.

353

A subset of oligodendrocytes generated from radial glia in the dorsal spinal cord

  Biology and Medicine Websites

Summary: ventricular zone (VZ) that also gives rise to motor neurons. Cell fate specification in this region depends neuroepithelium ­ specifically in the pMN domain, which also gives rise to motor neurons (MNs) (Warf et al., 1991 by Rowitch, 2004). Induction of oligodendrocyte progenitors (OLPs) is dependent on Sonic hedgehog (Shh

Richardson, William D.

354

ORIGINAL ARTICLE The Use of Biomedical Sensors to Monitor Capsule

  Engineering Websites

Summary: of an increase in viscous dissipation of the tissue. As collagen displaces the cellular response, the amplitude in patients and even delivering a lifesaving shock if ventricular fibrillation is detected.1­3 Monitoring situations. Therefore, in these experiments we have implanted these 2 types of sensors into rats and studied

Giurgiutiu, Victor

355

Cardiac Output Monitoring by Echocardiography: Should We Pass on Swan-Ganz Catheters?

  CiteSeer

Summary: Transesophageal echocardiography offers a noninvasive technique for the continuous monitoring of cardiac performance. The combination of 2-dimensional echocardiography and Doppler velocitometry provide assessment of cardiac anatomy, valve function and, ventricular loading conditions. Although transesophageal echocardiography has become accepted for perioperative monitoring, it is typically used in conjunction with Swan-Ganz catheterization. To supplant Swan-Ganz catheters, an echocardiographic technique to monitor cardiac output is necessary. Despite considerable effort to achieve this goal, a satisfactory technique has been difficult to realize. This paper discusses the role of cardiac output monitoring in perioperative care and critically examines echocardiographic techniques for cardiac output monitoring. Swan-Ganz (S-G)b catheterization provides a sophisticated assessment of cardiac performance not previously attainable in the clinical setting. Measurements of ventricular preload, mixed venous oxygen content, and CO have proven useful for diagnosis and to guide therapy. Although noninvasive monitoring modalities have experienced startling

Albert C. Perrino
1993-01-01

356

References

  CiteSeer

Summary: A noninvasive imaging modality for cardiac electrophysiology and arrhythmias is not yet available for clinical application. Such modality could be used to identify patients at risk, provide accurate diagnosis and guide therapy. Standard noninvasive diagnostic techniques, such as the electrocardiogram (ECG) provide only low-resolution reflection of cardiac electrical activity on the body surface. In my presentation, I will describe the application in humans of a new imaging modality called Electrocardiographic Imaging (ECGI) that noninvasively images cardiac electrical activity on the heart’s epicardial surface. In ECGI, a multielectrode vest (or strips) records 250 body-surface electrocardiograms; then, using geometrical information from a CT scan and an inverse solution to Laplace equation, electrical potentials, electrograms, activation sequences (isochrones) and repolarization patterns are reconstructed on the heart‘s surface. I will show examples of imaged atrial and ventricular activation and ventricular repolarization

C. Ramanathan; R. N. Ghanem; P. Jia; K. Ryu; Y. Rudy; C. Ramanathan; P. Jia; R. N. Ghanem; K. Ryu; Y. Rudy

357

Journal of Cardiovascular Magnetic Resonance ® , 3(3), 195–208 (2001) Myocardial Viability: Magnetic Resonance Assessment of Functional Reserve and Tissue Characterization

  CiteSeer

Summary: The determination of myocardial viability is crucial in patients with left ventricular dysfunction resulting from acute myocardial ischemia or chronic coronary artery disease. Viable myocardium will most likely benefit from revascularization procedures. However, the revascularization of scar tissue will not lead to improvement of ventricular function and furthermore bears unnecessary risk for the patient. Currently, echocardiographic and radionuclide techniques are the most established methods for the assessment of presence and extent of viable myocardium. Magnetic resonance imaging (MRI) also provides multiple approaches for determining viability of acute ischemically injured and hibernating myocardium. MRI can assess contractile reserve in a manner similar to echocardiography. Additionally, contrastenhanced MRI can characterize myocardial ischemic injury, including the ability to discriminate viable from nonviable zones. Several new contrast media have been introduced for this purpose. This review addresses the progress toward the goal of defining myocardial viability based on MR techniques and focuses on the current and future role of MR in the assessment of viable myocardium.

Norbert Watzinger; Maythem Saeed; Michael F; Haydar Akbari; Gunnar Lund; Charles B. Higgins

358

Calreticulin is essential for cardiac development

  CiteSeer

Summary: Abstract. Calreticulin is a ubiquitous Ca 2 ? binding protein, located in the endoplasmic reticulum lumen, which has been implicated in many diverse functions including: regulation of intracellular Ca 2 ? homeostasis, chaperone activity, steroid-mediated gene regulation, and cell adhesion. To understand the physiological function of calreticulin we used gene targeting to create a knockout mouse for calreticulin. Mice homozygous for the calreticulin gene disruption developed omphalocele (failure of absorption of the umbilical hernia) and showed a marked decrease in ventricular wall thickness and deep intertrabecular recesses in the ventricular walls. Transgenic mice expressing a green fluorescent protein reporter gene under the control of the calreticulin promoter were used to show that the calreticulin

Nasrin Mesaeli; Kimitoshi Nakamura; Elena Zvaritch; Peter Dickie; Ewa Dziak; Karl-heinz Krause; Michal Opas; David H. Maclennan; Marek Michalak
1999-01-01

359

Address for correspondence

  CiteSeer

Summary: Obese subjects are more prone to sudden deaths and arrhythmias than non-obese subjects. Heart rate turbulence (HRT) impairment reflects cardiac autonomic dysfunction, in particular impaired baroreflex sensitivity and reduced parasympathetic activity. Our aim was to evaluate the cardiac autonomic function in obesity by the HRT method. Ninety obese subjects and 112 healthy subjects were included in the study. Twenty-four hours ambulatory electrocardiograms were recorded and Holter recordings were analyzed. HRT parameters, turbulence onset (TO) and turbulence slope (TS), were calculated with HRT View Version 0.60-0.1 software program. HRT were calculated in 43 obese and 43 control subjects who had at least one ventricular premature beat in their Holter recordings. We excluded 47 obese patients and 69 control subjects who showed no ventricular premature beats in their Holter recordings from the statistical analysis. There were no significant differences in TO and TS between obese and control subjects (TO obese:-1.6±2.2%, TO

Alaettin Avsar; Gursel Acarturk; Mehmet Melek; Celal Kilit; Atac Celik; Ersel Onrat; Alaettin Avsar M. D
2006-01-01

360

CIMS Balloon Pump: A Novel Left Ventricle Assist Device (LVAD)

  CiteSeer

Summary: estimated to be at 63,500 every year. The probability of death within one year of diagnosis is 40%, if untreated (1). Heart failure treatment varies from lifestyle change, pharmacological treatment or surgical intervention. For advanced stages HF patients, heart transplant is the gold standard treatment. However, since donors are scarce resulting only 3000 operation/year worldwide, the next best treatment is mechanical heart assist device. 2) Aim & Objectives The aim of this study is to develop mechanical heart assist device specifically for left ventricle i.e. left ventricular assist device (LVAD) system that is able to restore heart health by reverse remodelling (self healing process). It is hypothesized reverse remodelling can be achieved by decreasing load faced by heart and increasing coronary perfusion. As such, objectives of this study are •To develop a prototype of balloon pump •To determine ventricular work reduction •To optimize of balloon pump design, including for in-vivo experiment

Zahran Khudzari; D. Richens; G. D. Tansley

361

failure in women

  CiteSeer

Summary: It is increasingly known that gender differences affect disease presentation, clinical pathways, diagnostic yield and prognosis of patients with cardiovascular disorders. There are novel insights regarding heart failure that provide a platform for personalized medicine. This is a review of the existent data about heart failure in women, a neglected topic that has gained considerable interest in the past years. Heart failure in women differs in many aspects from that of men. Part of the difference is attributable to age, ventricular function and cause of heart failure, with women being generally older at heart failure onset, more often without left ventricular systolic dysfunction and less often having heart failure due to ischaemic heart disease, in comparison with men. Elucidation of the genetic and pathophysiological basis of sex differences, together with clinical trials designed to study the impact of treatments in women, could lead to sex based heart failure management.

Ginghin? C; Botezatu Cd; ?erban M; Jurcu? R

362

Commentary Is tissue Doppler echocardiography the Holy Grail for the intensivist?

  CiteSeer

Summary: Assessment of left ventricular diastolic function in the critically ill patient remains a difficult issue in clinical practice. Combined use of routine transmitral and pulmonary venous Doppler patterns in conjunction with tissue Doppler imaging have been claimed to allow bedside diagnosis of diastolic dysfunction. Although in the previous issue of Critical Care it was clearly demonstrated there might be a difference in load dependency of the early myocardial tissue Doppler velocity between lateral and septal placed sample volume, there remain still several unanswered questions, particularly with respect to the preload dependency of these indices. The clinical evaluation of left ventricular (LV) diastolic function has been a difficult challenge. LV filling and pulmonary venous Doppler patterns have been utilized to estimate LV

Jan Poelaert; Carl Roosens
2007-01-01

363

Georg-August-Universitt Gttingen, Bereich Humanmedizin Publikationen und Hochschulschriften 2005

  Biology and Medicine Websites

Summary: ) A new endocardial "over-the-wire" or stylet-driven left ventricular lead: first clinical experience (2005) Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. EUR-surface-potential-maps by utilizing a common 12-lead-ECG device. IEEE T BIO-MED ENG, 52(3): 463-70. 12. Kockskämper J, Zima AV

Gollisch, Tim

364

Case Report Transient Global Amnesia After Ablation of the Left Lateral Accessory Pathway

  CiteSeer

Summary: chinghui/at/cch.org.tw Transient global amnesia (TGA) could be encountered in many situations even during invasive procedures. In ablation therapy for arrhythmia, there was only one reported case in the ablation of premature ventricular beats. We report a 31-year-old man having paroxysmal supraventricular tachycardia who underwent TGA at the end of ablation and recovered quickly after 8-9 hours later. Long-term follow-up showed no neurologic deficits for 8 months.

Chen-ying Chou; Ching-pei Chen; Ching-hui Huang

365

Tako-Tsubo Cardiomyopathy in a 92-Year Old Woman

  CiteSeer

Summary: Abstract: Tako-Tsubo cardiomyopathy (TTC) is an acute reversible cause of segmental myocardial dysfunction that is poorly understood and cannot be explained by the occlusion of a single coronary vessel. Its clinical presentation is similar to that of acute coronary syndrome and is often precipitated by a severe psychological or physical stress. Keywords: midventricular transient left ventricular dysfunction syndrome, Tako-Tsubo cardiomyopathy, menopause, breast cancer

Mariana S. Parahuleva; Mathias Grebe; Christiane Neuhof; Harald Tillmanns; Ali Erdogan

366

Hyperinsulinemia improves ischemic LV function in insulin resistant subjects

  University of Cambridge - Dspace

Summary: pressure being recorded at baseline and at the end of each stage of dobutamine. Standard clinical endpoints were used, including intol- erable symptoms (such as chest pain), > 2 mm of planar or down-sloping ST-segment depression, persistent arrhythmias... such as ventricular tachycardia or atrial fibrillation, and hypotension (a fall of systolic pressure 30 mmHg) or bradycardia. Image acquisition All echocardiographic images were obtained with a stan- dard, 2D echocardiography system (Vivid Seven, GE Medical Systems...

Heck, Patrick M; Hoole, Stephen P; Khan, Sadia N; Dutka, David P
2010-06-24

367

Classification of brain compartments and head injury lesions by neural networks applied to magnetic resonance images

  Texas A&M University - TxSpace

Summary: of therapeutic/preventative treatment, it is advantageous to be able to measure brain volumes [1] . 'Changes in the volume of brain tissue and in ventricular size have been noted in a variety of conditions, such as alcoholic dementia and schizophrenia [1...] . ' Computer-based quantitative methods allow an approximate measurement of tissue volumes, as well as the identification of lesions. For example, in acquired immunodeficiency syndrome (AIDS) dementia complex (ADC), the response to azidothymidine (AZT...

Kischell, Eric Robert
2012-06-07

368

Edmonton, Alta. References

  CiteSeer

Summary: jury pattern (after resuscitation from a ventricular fibrillation arrest) has a much higher risk of mortality than a patient with an average inferior my-ocardial infarction of the type reported in the Fibrinolytic Therapy Trialists’ overview, i.e., at least 17.4 % on the ba-sis of a simple risk index calculation de-rived from the InTIME II substudy.5 Thus, the benefits in this case clearly outweigh the risks.

Paul W. Armstrong; Wallentin L; The Riks-hia; Morrow Da; Antman Em; Giugliano Rp; Cairns R; Charlesworth A; Murphy Sa; Et Al. A

369

'. exp. Biol. (1975). 6a. 45-+2 405 'M 8 figures

  Environmental Sciences and Ecology Websites

Summary: innervating antagonistic muscles. Thus alternation in activity between the single LC and the two LG neurones), there is a corresponding loss of complexity and hence 'interest' in the behavioural patterns involved. The crustacean cardiac Pyloric Ventricular dilator No. I I 4 2 I I a i i i 7 i Muscles gm6b gm9 gmi, 2b, 3c gnvja gm4 c6

Hartline, Daniel K.

370

Entropy Index as a Measure of Heartbeat Irregularity

  HEP - Phenomenology (arXiv)

Summary: A method is proposed to analyze the heartbeat waveform that can yield a reliable characterization of the structure after only a few pulses. The measure suggested is entropy index that is related to the one found effective in describing chaotic behaviors in a wide variety of physical systems. When applied to the ECG data that include ventricular fibrillation, the index is shown to change drastically within a few pulses. Wavelet analysis is used to exhibit different scaling behaviors in different phases.

Rudolph C. Hwa
1998-09-29

371

DOI 10.1007/s00415-006-0245-5 REVIEW

  CiteSeer

Summary: j Abstract Human hydrocephalus is a common medical condition that is characterized by abnormalities in the flow or resorption of cerebrospinal fluid (CSF), resulting in ventricular dilatation. Human hydrocephalus can be classified into two clinical forms, congenital and acquired. Hydrocephalus is one of the complex and multifactorial neurological disorders. A growing body of evidence indicates that genetic factors play a major role in the pathogenesis of hydrocephalus. An understanding

Jun Zhang; Michael A. Williams; Daniele Rigamonti; M. A. Williams; Æ D. Rigamonti; M. A. Williams
2006-01-01

372

Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions

  University of Cambridge - Dspace

Summary: patients could lead to heart transplantation (Tx) with or without the use of a ventricular assist device (VAD) to sup- port heart function in the interim [3]. As new interven- tions for cardiac patients with different levels of disease severity... treadmill time (ETT), CCS angina classifi- cation and Seattle Angina Questionnaire (SAQ) scales. Methods The EQ-5D index The EQ-5D questionnaire consists of 5 questions covering the following health domains: mobility, self-care, usual activity, pain...

Goldsmith, Kimberley A; Dyer, Matthew T; Schofield, Peter M; Buxton, Martin J; Sharples, Linda D
2009-11-26

373

A Hydro-elastic Model of Hydrocephalus

  CiteSeer

Summary: this paper we construct a model of the brain and ventricular system which is su#ciently complex to reproduce the behaviour of the hydrocephalic brain yet simple enough to be mathematically tractable, and use the model to analyse the onset and treatment of the condition. A review of the general area of application of poroelascticty to the brain may be found in Tenti et al. (2000)

A. Smillie; I. Sobey; Z. Molnar
2004-01-01

374

pubs.acs.org/ICPublished on Web 06/14/2010r 2010 American Chemical Society Inorg. Chem. 2010, 49, 64616467 6461

  Chemistry Websites

Summary: capacity of ca. 133 mAh/g above 3 V (vs Liþ /Li) delivered by two biphasic transitions at 3.46 and 3.39 V (vs Liþ /Li). The unique crystal structure of SMOFC enables a high silver ion conduction: ^[001] = 3 ventricular fibrillation and correct it by administering an electrical shock to the right ventricle.1,2 Ag2V4O

Poeppelmeier, Kenneth R.

375

Effect of passive and active immunization against somatostatin in growing rats and cattle

  Texas A&M University - TxSpace

Summary: in the hypothalamus. Bohlen et al. ( 1983) processed eight human hypothalamic fragments, in the same manner as were the pancreatic tumors, and found, by bioassay and radio- immunoassay, two forms of GRF activity. Guillemin et al. (1984) stated that this data... and mean GH levels were significantly higher (Kata kami et al. , 1983). The possibility of GH inhibition by glucagon via stimulation of hypothalamic SS was supported by demonstrating that lateral ventricular injection of glucagon increased SS...

Lawrence, Mark Elliott
2012-06-07

376

cardiac stem cells are multipotent and support myocardial regeneration. Cell

  CiteSeer

Summary: Evidence challenging the accepted wisdom has been slowly accumulating (McDonnell and Oberpriller, 1984; Rumyantsev and Broisov, 1987). In the past few years, we have documented the existence of cycling ventricular myocytes in the normal and pathologic adult mammalian heart of several species, including humans (Kajstura et al., 1998; Beltrami et al., 2001; Quaini et al., 1Cardiovascular Research Institute 2002). Although these data provided an alternative view

Antonio P. Beltrami; Laura Barlucchi; Daniele Torella; Mathue Baker; Federica Limana; Stefano Chimenti; Hideko Kasahara; Marcello Rota; Ezio Musso; Konrad Urbanek; Annarosa Leri; Piero Anversa

377

Universittsmedizin Gttingen Publikationen und Hochschulschriften 2008

  Biology and Medicine Websites

Summary: coronary microembolization in sheep. J CARDIOVASC SURG, 49(4): 533-7. 10. Schmitto JD, Fatehpur S, Tezval H ventricular assist device in a sheep model. ASAIO J, 54(3): 233-6. 13. Schmitto JD, Hein S, Bräuer A, Popov AF microembolization in sheep. INT J ARTIF ORGANS, 31(4): 348-53. 15. Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber

Gollisch, Tim

378

Bisphenol A and 17b-Estradiol Promote Arrhythmia in the Female Heart via Alteration of Calcium Handling

  CiteSeer

Summary: Background: There is wide-spread human exposure to bisphenol A (BPA), a ubiquitous estrogenic endocrine disruptor that has been implicated as having potentially harmful effects on human heart health. Higher urine BPA concentrations have been shown to be associated with cardiovascular diseases in humans. However, neither the nature nor the mechanism(s) of BPA action on the heart are understood. Methodology/Principal Findings: The rapid (,7 min) effects of BPA and 17b-estradiol (E2) in the heart and ventricular myocytes from rodents were investigated in the present study. In isolated ventricular myocytes from young adult females, but not males, physiological concentrations of BPA or E2 (10 29 M) rapidly induced arrhythmogenic triggered activities. The effects of BPA were particularly pronounced when combined with estradiol. Under conditions of catecholamine stimulation, E2 and BPA promoted ventricular arrhythmias in female, but not male, hearts. The cellular mechanism of the female-specific pro-arrhythmic effects of BPA and E2 were investigated. Exposure to E2 and/or BPA rapidly altered myocyte Ca 2+ handling; in particular, estrogens markedly increased sarcoplasmic reticulum (SR) Ca 2+ leak, and increased SR Ca 2+ load. Ryanodine (10 27 M) inhibition of SR Ca 2+ leak suppressed estrogen-induced triggered activities. The rapid response of female myocytes to estrogens was abolished in an estrogen receptor (ER) b knockout mouse model. Conclusions/Significance: Physiologically-relevant concentrations of BPA and E2 promote arrhythmias in a female-specific

Sujuan Yan; Yamei Chen; Min Dong; Weizhong Song; Scott M. Belcher; Hong-sheng Wang

379

Differences in Na and Ca spikes as examined by application of tetrodotoxin, procaine, and manganese

  CiteSeer

Summary: ABSTRACT The effects of tetrodotoxin, procaine, and manganese ions were examined on the Ca spike of the barnacle muscle fiber injected with Cabinding agent as well as on the action potential of the ventricular muscle fiber of the frog heart. Although tetrodotoxin and procaine very effectively suppress the "Na spike " of other tissues, no suppressing effects are found on "Ca spike" of the barnacle fiber, while the initiation of the Ca spike is competitively inhibited by manganese ions. The initial rate of rise of the ventricular action potential is suppressed by tetrodotoxin and procaine but the plateau phase of the action potential is little affected. In contrast the suppressing effect of manganese ions is mainly on the plateau phase. The results suggest that the plateau phase of the ventricular action potential is related to the conductance increase in the membrane to Ca ions even though Na conductance change may also contribute to the plateau. Spike potentials of most excitable tissues such as the squid giant axon (Hodgkin and Katz, 1949) and the skeletal muscle fiber of the frog (Nastuk and Hodgkin,

Susumu Hagiwara; Shigehiro Nakajima
1966-01-01

380

Korean Circulation Journal Pressure Tracings in Hypertrophic Cardiomyopathy With Dynamic Midventricular Obstruction

  CiteSeer

Summary: A 50-year-old man was admitted for evaluation of syncope. Clinically, he had an irregular pulse and an ejection systolic murmur loudest at the left sternal border. Transthoracic echocardiography revealed hypertrophic cardiomyopathy (HCM) with midventricular obstruction and apical aneurysm with maximum pressure gradient greater than 74 mm Hg. Coronary angiogram showed normal coronary arteries. Left ventriculogram using 4 Fr pigtail catheter via right radial approach showed nearly total obliteration of left ventricular (LV) cavity at the midventricular level (arrows) with apical aneurysm (Fig. 1A and B). Pressure tracing from LV apex to the aorta showed a significant systolic pressure gradient within the left ventricular cavity (Fig. 1C). The day after cardiac catheterization, he complained of palpitation and mild dizziness and an electrocardiogram showed sustained monomorphic ventricular tachycardia (VT) of LV apical origin. The final diagnosis was HCM with midventricular obstruction complicated by VT. HCM is an extremely heterogeneous disease. In a patient with HCM with midventricular obstruction and apical aneurysm, VT arising from the scarred aneurysm wall often occurs, predisposing the patient to sudden cardiac death. 1)2) In a patient with HCM with severe midventricular obstruction, catheterization of LV apex is very difficult. The pressure tracings in this patient strongly resembled those of HCM with LV outflow tract (LVOT) obstruction, but the pressure gradient existed between LV apex and LVOT, not between LVOT and aorta.

Hee-chan Jung; Ji-hoon Kim

381

Six-months of recombinant human GH therapyin patients with Ischemic Cardiac failure

  CiteSeer

Summary: Growth hormone therapy in patients with idiopathic dilated cardiomyopathy and ischemic cardiac failure has revealed varying effects on systolic function, probably related to the response in serum insulin like growth factor Ilevels.As diastolic function has not been studied thoroughly, we studied the effects of 6months of recombinant human growth hormone treatment on systolic and diastolic function in patients with ischemic cardiac failure, using cardiovascular Magnetic Resonance imaging. Nineteenpatients with ischemic cardiac failure (left ventricular ejection fraction < 40%)were studied in a randomized trial.Ten patients received during 6months treatment with growth hormone (2IU/d), 9served as controls.Systolic and diastolic function were assessed at baseline and after 26weeks by cardiovascular Magnetic Resonance imaging.No differences were found in systolic and diastolic function between rh GH treated patients and controls.No change was observed in left ventricular mass index, end-diastolic volume, end-systolic-volume and ejection fraction.The treated patients showed no clinical improvement. Six months of treatment with growth hormone therapy in ischemic cardiac failure has no favorable effects on left ventricular mass index, on systolic and diastolic function. 118 rhGH therapyinpatientsischemiccardiacfailure

Sjoerd W Van Thiel; Jan Wa Smit; Jeroen J Bax; Albert De Roos; Ernst E Van Der Wall; Nienke R Biermasz; Hubert W Vliegen; Johannes A Romijn M; Hildo J Lamb

382

Mechanisms of altered excitationcontraction coupling in canine tachycardia-induced heart failure, ii model studies

  CiteSeer

Summary: transients measured in failing human ventricular myocytes exhibit reduced amplitude, slowed relaxation, and blunted frequency dependence. In the companion article (O’Rourke B, Kass DA, Tomaselli GF, Kääb S, Tunin R, Marbán E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart, I: experimental studies. Circ Res. 1999;84:562–570), O’Rourke et al show that Ca2 ? transients recorded in myocytes isolated from canine hearts subjected to the tachycardia pacing protocol exhibit similar responses. Analyses of protein levels in these failing hearts reveal that both SR Ca2 ? ATPase and phospholamban are decreased on average by 28 % and that Na ? /Ca2 ? exchanger (NCX) protein is increased on average by 104%. In this article, we present a model of the canine midmyocardial ventricular action potential and Ca2 ? transient. The model is used to estimate the degree of functional upregulation and downregulation of NCX and SR Ca2 ? ATPase in heart failure using data obtained from 2 different experimental protocols. Model estimates of average SR Ca2 ? ATPase functional downregulation obtained using these experimental protocols are 49 % and 62%. Model estimates of average NCX functional upregulation range are 38 % and 75%. Simulation of voltage-clamp Ca2 ? transients indicates that such changes are sufficient to account for the reduced amplitude, altered shape, and slowed relaxation of Ca2 ? transients in the failing canine heart. Model analyses also suggest that altered expression of Ca2 ? handling proteins plays a significant role in prolongation of action potential duration in failing canine myocytes. (Circ Res. 1999;84:571-586.) Key Words: excitation-contraction coupling ? heart failure ? midmyocardial ventricular action potential

Raimond L. Winslow; Jeremy Rice; Saleet Jafri; Eduardo Marbán
1999-01-01

383

Research Right Heart Pressure Increases after Acute Increases in Ambient Particulate Concentration

  CiteSeer

Summary: OBJECTIVES: We explored the association between acute changes in daily mean pulmonary artery (PA) and right ventricular (RV) pressures and concentrations of ambient fine particulate matter [PM with aerodynamic diameter ? 2.5 µm (PM2.5)] as an explanation for previous associations between congestive heart failure (HF) hospital admissions and PM. MATERIALS AND METHODS: In the Chronicle Offers Management to Patients with Advanced Signs and Symptoms of Heart Failure (COMPASS-HF) trial, to see whether management of ambulatory HF could be improved by providing continuous right heart pressure monitoring to physicians, the

David Q. Rich; Ronald S. Freudenberger; Pamela Ohman-strickl; Yong Cho; Howard M. Kipen

384

Open Access Management of Cardiac Involvement in NeuroMuscular Diseases: Review

  CiteSeer

Summary: Abstract: Neuromuscular Diseases are a heterogeneous molecular, clinical and prognosis group. Progress has been achieved in the understanding and classification of these diseases. Cardiac involvement in neuromuscular diseases namely conduction disorders, ventricular dilatation and dilated cardiomyopathy with its impact on prognosis, is often dissociated from the peripheral myopathy. Therefore, close surveillance is mandatory in the affected patients. In this context, preventive therapy (beta-blockers and angiotensin converting enzyme inhibitors) has been recently recommended in the most common Neuromuscular Diseases, Duchenne Muscular Dystrophy and Myotonic Dystrophy. Key Words: Muscular dystrophy, cardiomyopathy, sudden cardiac death.

Rachida Bouhouch; Tarik Elhouari; Latifa Oukerraj; Ibtissam Fellat; Jamila Zarzur; Rajaa Bennani; Mhamed Arharbi; Service De Cardiologie B; Chu Ibn; Sina Rabat

385

Spatiotemporal dynamics of pacing in models of anatomical reentry

  Nonlinear Sciences (arXiv)

Summary: Reentry around non-conducting ventricular scar tissue, which often causes lethal arrhythmias, is typically treated by rapid stimulation from an implantable defibrillator. However, the mechanisms of termination (success and failure) are poorly understood. To elucidate such mechanisms, we studied pacing of anatomical reentry in 1-D and 2-D excitable cardiac media models. Our results suggest that the existence of inhomogeneity in the reentry circuit is essential for pacing termination of tachycardia to be successful. Considering the role of such inhomogeneities may lead to more effective pacing algorithms.

Sitabhra Sinha; David J. Christini
2001-07-30

386

DOI 10.1007/s12265-011-9344-5 Left Bundle Branch Block, an Old–New Entity

  CiteSeer

Summary: Abstract Left bundle branch block (LBBB) is generally associated with a poorer prognosis in comparison to normal intraventricular conduction, but also in comparison to right bundle branch block which is generally considered to be benign in the absence of an underlying cardiac disorder like congenital heart disease. LBBB may be the first manifestation of a more diffuse myocardial disease. The typical surface ECG feature of LBBB is a prolongation of QRS above 0.11 s in combination with a delay of the intrinsic deflection in leads V5 and V6 of more than 60 ms and no septal q waves in leads I, V5, and V6 due to the abnormal septal activation from right to left. LBBB may induce abnormalities in left ventricular performance due to abnormal asynchronous contraction patterns which can be compensated by biventricular pacing (resynchronization therapy). Asynchronous electrical activation of the ventricles causes regional differences in workload which may lead to asymmetric hypertrophy and left ventricular dilatation, especially due to increased wall mass in late-activated regions, which may This article is partly based on a previous publication by G. Breithardt et al. [1].

Günter Breithardt; Er Breithardt; G. Breithardt; O. -a. Breithardt; O. -a. Breithardt
2011-01-01

387

Summary

  CiteSeer

Summary: The linear dimensions of the ventricle of an in situ perfused trout heart were measured with an ultrasound scanner. Using a pyramidal model, linear dimensions taken from real-time, two-dimensional, echotomographic images of the ventricle were used to calculate ventricular end-diastolic and end-systolic volumes and, by the difference between them, stroke volumes for various filling and output pressures. Stroke volumes calculated from the ultrasound measurements were significantly correlated with actual stroke volumes determined from cardiac output and heart rate and had a regression line slope close to one. Increases in stroke volume with greater filling pressures resulted from increased ventricular end-diastolic volume with constant end-systolic volume; end-systolic volumes were negligible. Maintenance of stroke volume with increasing output pressure was by increases in both end-diastolic and end-systolic volumes. Decreases in stroke volume with very high output pressures may result from convergence of end-systolic and end-diastolic volumes.

E. Franklin; Peter; S. Da Vie
1992-01-01

388

Thermal acclimation alters both adrenergic sensitivity and adrenoceptor density in cardiac tissue of rainbow trout

  CiteSeer

Summary: We examined the effect of temperature acclimation on the sensitivity of the rainbow trout heart to adrenaline and on the density of ?-adrenoceptors. The sensitivity of the heart was assessed using in situ working perfused heart and in vitro isometric ventricular strip preparations. When tested in situ and at acclimation temperature, hearts from fish acclimated to 8?C were approximately 10-fold more sensitive to adrenalinesupplemented perfusate than were hearts from fish acclimated to 18?C. The concentrations required for half-maximal stimulation (EC50) of myocardial power output were 1.9?10 ?8 mol l ?1 adrenaline and 1.7?10 ?7 mol l ?1 adrenaline for hearts acclimated to 8?C and 18?C, respectively. In vitro, isometric ventricular strip preparations demonstrated a similar increase in adrenergic sensitivity with coldacclimation. The EC50 values for maximal tension development were 2.7?10 ?7 mol l ?1 adrenaline (8?C-acclimated) and 1.1?10 ?6 mol l ?1 adrenaline (18?C-acclimated) when tested at acclimation temperature. This shift in adrenergic sensitivity was a function of the temperature acclimation because changes in bath temperature per se, either from 8?C to 18?C for 8?C-acclimated hearts or from 18?C to 8?C for 18?C-acclimated hearts, had

John E. Keen; Daisy-mae Vianzon; Anthony P. Farrell; Glen F. Tibbits
1993-01-01

389

Regulated nuclear trafficking of the homeodomain protein otx1 in cortical neurons. Mol. Cell Neurosci

  CiteSeer

Summary: Otx1 is a homeodomain protein required for axon refinement by layer 5 neurons in developing cerebral cortex. Otx1 localizes to the cytoplasm of progenitor cells in the rat ventricular zone, and remains cytoplasmic as neurons migrate and begin to differentiate. Nuclear translocation occurs during the first week of postnatal life, when layer 5 neurons begin pruning their long-distance axonal projections. Deletion analysis reveals that Otx1 is imported actively into cell nuclei, that the N-terminus of Otx1 is necessary for nuclear import, and that a putative nuclear localization sequence within this domain is sufficient to direct nuclear import in a variety of cell lines. In contrast, GFP–Otx1 fusion proteins that contain the N-terminus are retained in the cytoplasm of cortical progenitor cells, mimicking the distribution of Otx1 in vivo. These results suggest that ventricular cells actively sequester Otx1 in the cytoplasm, either by preventing nuclear import or by promoting a balance of export over import signals.

Y. Alex Zhang; Ami Okada; Chuen Hong Lew; Susan K. Mcconnell
2002-01-01

390

Heart-induced movements in the thorax as detected by MRI

  CERN Preprints

Summary: In order to provide information for the use of radar in diagnostics a qualitative map of movements in the thorax has been obtained. This map was based on magnetic resonance image sequences of a human thorax during suspended respiration. The movements were measured using two distinct techniques. Segmentation provided measures of aorta dilatation and displacements, and image edge detection indicated other movements. The largest heart movements were found in the anterior and left regions of the heart with in-plane displacements on the order of 1 cm and which caused lung vessels displacements on the order of 2-3mm especially on the left side due to the heart ventricular. Mechanical coupling between the heart and aorta caused aorta displacements and shape distortions. Despite this coupling, aorta dilatations most likely reflected blood pressure variations.

Solberg, Lars Erik; Fosse, Erik; Hol, Per Kristian
2014-01-01

391

Copyright © 2012 Termedia & Banach Corresponding author:

  CiteSeer

Summary: Cardiac pacing is a proven therapy of cardiac conduction disturbances and an effective treatment modality in many cardiac arrhythmias. Implantable cardiac defibrillators (ICDs) are particularly beneficial for selected groups of patients with a history of severe ventricular arrhythmias or at a high risk of sudden cardiac death. Despite their potential lifesaving properties, both pacemakers and ICDs are associated with a number of complications. The most frequent include pneumothorax; myocardial perforation; lead malposition, displacement or fracture due to excessive manipulation of the device by the patient (Twiddler’s syndrome) [1]. Another group of complications comprises infections: from the pacemaker pocket to bacterial endocarditis with its origin on leads or the tricuspid valve, failure of leads to pace and/or sense appropriately, erosion of the pacemaker site or its leads, and thrombotic events with the most frequently observed subclavian vein thrombosis [2]. In the era of massive anticoagulation and antiplatelet therapy bleeding complications are not uncommon,

Marek Banaszewski; Janina St?pi?ska; Prof Janina; St?pi?ska Md
2012-01-01

392

Cardiac Autonomic Nervous System in Heart Failure: Imaging Technique and Clinical Implications

  CiteSeer

Summary: Abstract: The autonomic nervous system interacts in the pathophysiology of heart failure. Dysfunction of the sympathetic nervous system has been identified as an important prognostic marker in patients with chronic heart failure. At present, cardiac sympathetic nerve imaging with 123-iodine metaiodobenzylguanidine [123-I MIBG] has been employed most frequently for the assessment of cardiac sympathetic innervation and activation pattern. The majority of studies have shown that cardiac sympathetic dysfunction as assessed with 123-I MIBG imaging is a powerful predictor for heart failure mortality and morbidity. Additionally, 123-I MIBG imaging can be used for prediction of potentially lethal ventricular tachyarrhythmias in heart failure patients. At present however, the lack of standardization of 123-I MIBG imaging procedures represents an evident issue. Standardized criteria on the use of 123-I MIBG imaging will further strengthen the clinical use of 123-I MIBG imaging in heart failure patients.

Mark J. Boogers; Caroline E. Veltman; Jeroen J. Bax

393

Quantitative Analysis of Heart Rate Variability

  CiteSeer

Summary: In the modern industrialized countries every year several hundred thousands of people die due to the sudden cardiac death. The individual risk for this sudden cardiac death cannot be defined precisely by common available, non-invasive diagnostic tools like Holter-monitoring, highly amplified ECG and traditional linear analysis of heart rate variability (HRV). Therefore, we apply some rather unconventional methods of nonlinear dynamics to analyse the HRV. Especially, some complexity measures that are basing on symbolic dynamics as well as a new measure, the renormalized entropy, detect some abnormalities in the HRV of several patients who have been classified in the low risk group by traditional methods. A combination of these complexity measures with the parameters in the frequency domain seems to be a promising way to get a more precise definition of the individual risk. These findings have to be validated by a representative number of patients. 1 Introduction Ventricular arrhythmi...

J. Kurths; A. Voss; A. Witt; P. Saparin; H. J. Kleiner; N. Wessel
1995-01-01

394

World Academy of Science, Engineering and Technology 60 2011 Microalbuminuria in Essential

  CiteSeer

Summary: Abstract—Essential hypertension (HTN) usually clusters with other cardiovascular risk factors such as age, overweight, diabetes, insulin resistance and dyslipidemia. The target organ damage (TOD) such as left ventricular hypertrophy, microalbuminuria (MA), acute coronary syndrome (ACS), stroke and cognitive dysfunction takes place early in course of hypertension. Though the prevalence of hypertension is high in India, the relationship between microalbuminuria and target organ damage in hypertension is not well studied. This study aim at detecting MA in essential hypertension and its relation to severity of HTN, duration of HTN, body mass index (BMI), age and TOD such as HTN retinopathy and acute coronary syndrome The present study was done in 100 patients of essential hypertension non diabetics admitted to

Sharan Badiger; Prema T. Akkasaligar; Eep Hm; Biradar Ms

395

Brain Image Registration Based on Curve Mapping

  CiteSeer

Summary: A new two-stage approach for brain image registration is proposed. In the first stage, an active contour algorithm is used to establish a length-preserving, one-to-one mapping between the cortical and the ventricular boundaries in the two images to be registered. This mapping is used in the second step by a two-dimensional transformation which is based on an elastic body deformation. This method was tested by registering magnetic resonance images to both photographic pathology images and atlas images. I. Introduction Registration of both intra-subject and inter-subject images has been the subject of extensive study in the medical imaging literature. It is important for several reasons. First, images obtained through different modalities can be properly superposed only after accurate registration. Visualization and quantitative analysis can be improved by such superposition. Second, atlas images accurately registered to patient data can be used for automatic identification of brain an...

Chris Davatzikos; Jerry L. Prince
1994-01-01

396

Mathematical modeling applied to the left ventricle of heart

  CERN Preprints

Summary: Background: How can mathematics help us to understand the mechanism of the cardiac motion? The best known approach is to take a mathematical model of the fibered structure, insert it into a more-or-less complex model of cardiac architecture, and then study the resulting fibers of activation that propagate through the myocardium. In our paper, we have attempted to create a novel software capable of demonstrate left ventricular (LV) model in normal hearts. Method: Echocardiography was performed on 70 healthy volunteers. Data evaluated included: velocity (radial, longitudinal, rotational and vector point), displacement (longitudinal and rotational), strain rate (longitudinal and circumferential) and strain (radial, longitudinal and circumferential) of all 16 LV myocardial segments. Using these data, force vectors of myocardial samples were estimated by MATLAB software, interfaced in the echocardiograph system. Dynamic orientation contraction (through the cardiac cycle) of every individual myocardial fiber could ...

Ranjbar, Saeed
2014-01-01

397

ICA applied to atrial fibrillation analysis

  CiteSeer

Summary: In this work we present a new biomedical application of independent component analysis (ICA) to solve the problem of atrial activity (AA) extraction from real electrocardiogram (ECG) recordings of atrial fibrillation (AF). The proper analysis and characterization of AA from ECG recordings requires, as a first step, the cancellation of ventricular activity (VA). The present contribution demonstrates the appropriateness of ICA to solve this problem based on three considerations: firstly AA and VA are generated by independent bioelectric sources, secondly AA and VA are subgaussian and supergaussian activities, respectively, and finally the surface ECG can be regarded as an instantaneous linear mixing process. After ICA algorithm application to recordings from 7 patients in AF, we prove that the AA source can be identified using a kurtosis-based reordering of the separated sources and a ulterior spectral analysis for those sources with subgaussian kurtosis. 1.

José Joaquín Rieta; Francisco Castells; César Sánchez; Jorge Igual
2003-01-01

398

VIVENDI - A Virtual Ventricle Endoscopy System for Virtual Medicine

  CiteSeer

Summary: . Virtual Medicine is an emerging and challenging field in Computer Graphics. Numerous visualization methods are used to model and render data of different modalities. In this paper, we present a new endoscopy system for virtual medicine. The main purpose of this system is to provide support for the planning of complicated endoscopic interventions inside of the ventricular system of the human brain. Although, our current focus is on ventricle endoscopy, this system is applicable to other areas as well. In order to achieve interactive framerates on workstations with medium graphics performance, we apply an efficient implementation of a basic algorithm for general visibility queries. Keywords: Virtual Medicine, Virtual Environments, Surgical Assist Systems. 1 Introduction Minimally-invasive neurosurgical procedures are of increasing importance in neurosurgery. In comparison to commonly used surgical techniques, less brain tissue is damaged. Furthermore, minimally-invasive pr...

Dirk Bartz; Martin Skalej
1999-01-01

399

The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2." Neuron 31

  CiteSeer

Summary: Olig2, a basic helix-loop-helix (bHLH) transcription factor, is expressed in a restricted domain of the spinal cord ventricular zone that sequentially generates mo-toneurons and oligodendrocytes. Just prior to oligodendrocyte precursor formation, the domains of Olig2 and Nkx2.2 expression switch from being mutually ex-clusive to overlapping, and Neurogenins1 and 2 are extinguished within this region. Coexpression of Olig2 with Nkx2.2 in the spinal cord promotes ectopic and precocious oligodendrocyte differentiation. Both proteins function as transcriptional repressors in this assay. This effect is blocked by forced expression of Neurogenin1. By contrast, misexpression of Olig2 alone derepresses Neurogenins and promotes motoneuron differentiation. Olig2 therefore functions sequentially in motoneuron and oligodendrocyte fate specification. This dual action is enabled by spatio-temporal changes in the expression domains of other transcription factors with which Olig2 functionally in-teracts.

Qiao Zhou; Gloria Choi; David J. Anderson; Division Of Biology
2001-01-01

400

www.ipej.org S75 Review Article Cardiac Anatomic Considerations in Pediatric

  CiteSeer

Summary: Although interventional electrophysiology and the use of radiofrequency energy to cure various arrhythmias primarily developed in the adult population, similar applications in children have grown dramatically over the last decade. The anatomic basis for various arrhythmias is critically important for the pediatric ablationists to appreciate. Such understanding allows the use of alternative technique to affect cure while avoiding complications. Further, because of the relatively small heart and less thick myocardium in children, without the appreciation of the underlying cardiac anatomic relationships, collateral injury, for example to the arterial system, may occur. In this review, the cardiac anatomic consideration important in approaching various supraventricular and ventricular arrhythmias in the normal heart is discussed. Key Words: cardiac anatomy; conduction system; electrophysiology; children; radiofrequency ablation

Samuel J. Asirvatham

401

Case report Tetany in association with gentamicin therapy

  CiteSeer

Summary: Magnesium plays a role in calcium metabolism and hypomagnesaemia can lead to hypocalcaemia.1 Recently it has been recognised that prolonged aminoglycoside therapy can cause hypomagnesaemia.2 3 We have recently observed tetany associated with low serum levels of both calcium and magnesium in a patient receiving gentamicin, which resolved when the gentamicin was stopped and the serum magnesium was corrected. CASE HISTORY A 21-year-old male with a congenital ventricular septal defect was admitted with a ten- day history of rigors, malaise and anorexia. Three out of six blood cultures grew Staphylococcus aureus. A diagnosis of infective endocarditis was made and treatment with intravenous flucloxacillin and gentamicin was begun. Frequent peak and trough gentamicin levels were maintained within the thera-peutic range. Eighteen days after treatment commenced, the pyrexia recurred and flucloxacillin was replaced by vancomycin. Three days later, he developed an allergic drug rash, and the vancomycin was changed to fusidic acid. Antibiotics

L Beatty; N P S Campbell; R D G Neely
1989-01-01

402

Noninvasive imaging of cardiac transmembrane potentials within three-dimensional myocardium by means of a realistic geometry anisotropic heart model

  CiteSeer

Summary: Abstract—We have developed a new approach for imaging cardiac transmembrane potentials (TMPs) within the three-di-mensional (3-D) myocardium by means of an anisotropic heart model. The cardiac TMP distribution is estimated from body surface electrocardiograms by minimizing objective functions of the “measured ” body surface potential maps (BSPMs) and the heart-model-generated BSPMs. Computer simulation studies have been conducted to evaluate the present 3-D TMP imaging approach using pacing protocols. Simulations of single-site pacing at 24 sites throughout the ventricles, as well as dual-site pacing at 12 pairs of sites in the vicinity of atrio-ventricular ring were performed. The present simulation results show that the correlation coefficient (CC) and relative error (RE) between the “true ” and inversely estimated TMP distributions were

Bin He; Senior Member; Guanglin Li; Xin Zhang; Student Member
2003-01-01

403

Adjuvant Use of Ivabradine in Acute Heart Failure due to Myocarditis

  CiteSeer

Summary: which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We report two cases of young men in whom acute heart failure due to myocarditis was diagnosed. The patients had been transferred to the intensive care unit (ICU) with commencing symptoms of acute heart failure and consecutive multiorgan failure for further treatment and to evaluate the indication for implantation of a ventricular assist device or for high urgent orthotopic heart transplantation. In both patients, the I f-channel inhibitor ivabradine was administered off-label to provide selective heart rate reduction, and thus support hemodynamic stabilization. Though currently considered off-label use in patients suffering from severe hypotension and acute heart failure, the use of ivabradine may beneficially influence outcome by allowing optimization of the patient’s heart rate concomitant to initial measures of clinical stabilization. 1.

Article Id; Jennifer Franke; Dorothee Schmahl; Stephanie Lehrke; Regina Pribe; Raffi Bekeredjian; Andreas O. Doesch; Hugo A. Katus; Christian Zugck

404

Increased Density of the Liver and Amiodarone-Associated

  CiteSeer

Summary: This is a case report in which a 60-year-old man who suffered from ventricular tachycardia with dilated cardiomyopathy was prescribed amiodarone. After taking amiodarone, liver enzymes were increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium. He was suspected as hemochromatosis and liver biopsy was performed. An abnormal high density of liver tissue may be observed in an unenhanced CT in patients treated with amiodarone and we suggest that periodic monitoring of liver function and/or liver biopsy is warranted before an irreversible stage is reached. Copyright © 2009 Sunao Kojima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 1.

Sunao Kojima; Shinobu Kojima; Hirofumi Ueno; Motohiro Takeya; Hisao Ogawa
2009-01-01

405

REPORTS

  CiteSeer

Summary: significant, dose-dependent, concentration-dependent, and visually evident changes in cardiac contractility as indicated by increases in FS (Fig. 4A and movie S1) (19). Omecamtiv mecarbil improved left ventricular systolic function in a conscious canine model with chronically implanted sensors to assess LV dimensions, atrial and arterial pressures, and stroke volume (20). The direct effect on cardiac contractility was evident from the increase in myocardial wall thickening (WT) and FS (Fig. 4B) in the absence of a change in loading conditions, such as mean arterial pressure, LV end diastolic pressure, and total vascular resistance (–2.2 T 1.3%, –7.3 T 5.8%, and –2.4 T 2.3%,

unknown authors

406

RNAbinding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulation of neurons in mammalian CNS

  CiteSeer

Summary: Musashi1 (Msi1) is a mammalian neural RNA-binding protein highly enriched in neural precursor cells that are capable of generating both neurons and glia during embryonic and postnatal CNS development. Here, we identified Musashi2 (Msi2), a novel mammalian RNA-binding protein that exhibits high sequence similarity to Msi1. The Msi2 transcript appeared to be distributed ubiquitously in a wide variety of tissues, consistent with the mRNA distribution of its Xenopus homolog, xrp1. However, the present study revealed cell type-specific and developmentally regulated expression of Msi2 in the mammalian CNS. Interestingly, Msi2 was expressed prominently in precursor cells in the ventricular zone and subventricular zone with the same pattern as Msi1 throughout CNS development. In the postnatal and adult CNS, this concurrent expression of Msi2 and Msi1 was seen in cells of the astrocyte lineage,

Shin-ichi Sakakibara; Yuki Nakamura; Hitoshi Satoh; Hideyuki Okano
2001-01-01

407

Recovery of soft tissue object deformation from 3d image sequences using biomechanical models

  CiteSeer

Summary: Abstract. The estimation of soft tissue deformation from 3D image sequences is an important problem in a number of fields such as diagnosis of heart disease and image guided surgery. In this paper we describe a methodology for using biomechanical material models, within a Bayesian framework which allows for proper modeling of image noise, in order to estimate these deformations. The resulting partial differential equations are discretized and solved using the finite element method. We demonstrate the application of this method to estimating strains from sequences of in-vivo left ventricular MR images, where we incorporate information about the fibrous structure of the ventricle. The deformation estimates obtained exhibit similar patterns with measurements obtained from more invasive techniques, used as a gold standard. 1

Xenophon Papademetris; Pengcheng Shi; Donald P. Dione; Albert J; R. Todd Constable; James S. Duncan
1998-01-01

408

Inferior ST-Elevation Myocardial Infarction Associated with

  CiteSeer

Summary: Copyright © 2010 Oliver Koeth et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Takotsubo cardiomyopathy (TCM) is usually characterized by transient left ventricular apical ballooning. Due to the clinical symptoms which include chest pain, electrocardiographic changes, and elevated myocardial markers, Takotsubo cardiomyopathy is frequently mimicking ST-elevation myocardial infarction in the absence of a significant coronary artery disease. Otherwise an acute occlusion of the left anterior descending coronary artery can produce a typical Takotsubo contraction pattern. ST-elevation myocardial infarction (STEMI) is frequently associated with emotional stress, but to date no cases of STEMI triggering TCM have been reported. We describe a case of a female patient with inferior ST-elevation myocardial infarction complicated by TCM. 1.

Article Id; Takotsubo Cardiomyopathy; Oliver Koeth; Uwe Zeymer; Rudolf Schiele; Ralf Zahn
2010-01-01

409

Distribution of Action Potential Duration and T-wave Morphology: a Simulation Study

  CERN Preprints

Summary: The results of a simulation study of the action potential duration (APD) distribution and T-wave morphology taking into account the midmyocardial cells (M-cells) concept are described. To investigate the effect of M-cells we present a computer model in which ion channel action potential formulations are incorporated into three-dimensional whole heart model. We implemented inhomogeneous continuous action potential duration distribution based on different distributions of maximal slow delayed rectifier current conductance. Using the proposed action potential distribution procedure midmural zeniths with longest action potential length were created as islands of model cells in the depth of thickest areas of ventricular tissue. Different spatial functions on layer indexes were simulated and their influences on electrocardiogram waveforms were analyzed. Changing parameters of ion channel model we varied duration of minimal and maximal action potential and investigated T-wave amplitude, Q-Tpeak and QT intervals vari...

Ryzhii, Elena; Wei, Daming
2009-01-01

410

Identifying Global Anatomical Differences: Deformation-Based Morphometry

  CiteSeer

Summary: The aim of this paper is to illustrate a method for identifying macroscopic anatomical differences among the brains of different populations of subjects. The method involves spatially normalizing the structural MR images of a number of subjects so that they all conform to the same stereotactic space. Multivariate statistics are then applied to the parameters describing the estimated nonlinear deformations that ensue. To illustrate the method, we have compared the gross morphometry of male and female subjects. We also assessed brain asymmetry, the effect of handedness, and the interactions among these effects. 1 Introduction In this paper we introduce a new technique to characterize differences among structural or anatomical brain images. The anatomical differences between any two brains can be expressed at a microscopic scale (e.g. differences in cytoarchitectonics or myeloarchitectonics), at a mesoscopic scale (e.g. cortical dysplasia) or at a macroscopic level (e.g. ventricular enl...

John Ashburner; Chloe Hutton; Richard Frackowiak; Ingrid Johnsrude; Cathy Price; Karl Friston; London Wcn Bg
1998-01-01

411

Detection, Properties, and Frequency of Local Calcium Release from the Sarcoplasmic Reticulum in Teleost

  CiteSeer

Summary: Calcium release from the sarcoplasmic reticulum (SR) plays a central role in the regulation of cardiac contraction and rhythm in mammals and humans but its role is controversial in teleosts. Since the zebrafish is an emerging model for studies of cardiovascular function and regeneration we here sought to determine if basic features of SR calcium release are phylogenetically conserved. Confocal calcium imaging was used to detect spontaneous calcium release (calcium sparks and waves) from the SR. Calcium sparks were detected in 16 of 38 trout atrial myocytes and 6 of 15 ventricular cells. The spark amplitude was 1.4560.03 times the baseline fluorescence and the time to half maximal decay of sparks was 2763 ms. Spark frequency was 0.88 sparks mm 21 min 21 while calcium waves were 8.5 times less frequent. Inhibition of SR calcium uptake reduced the calcium transient (F/F0) from 1.7760.17 to 1.1260.18 (p = 0.002) and abolished calcium sparks and waves. Moreover, elevation of extracellular calcium from 2 to 10 mM promoted early and delayed afterdepolarizations (from 0.660.3 min 21 to 8.162.0 min 21, p = 0.001), demonstrating the ability of SR calcium release to induce afterdepolarizations in the trout heart. Calcium sparks of similar width and duration were also observed in zebrafish ventricular myocytes. In conclusion, this is the first study to consistently report calcium sparks in teleosts and demonstrate that the basic features of calcium release through the ryanodine receptor are conserved, suggesting that teleost cardiac myocytes is a relevant model

Anna Llach; Cristina E. Molina; Enrique Alvarez-lacalle; Lluis Tort; Raul Benítez; Leif Hove

412

Open Access Successful Treatment of Novel H1N1 Influenza related Fulminant Myocarditis with Extracorporeal Life Support

  CiteSeer

Summary: The prevalence of myocardial involvement in influenza infection ranges from 0 % to 12%. The 2009 pH1N1 influenza virus, formerly known as swine flu, first appeared in Mexico and the United States of America in March and April 2009 and has swept the globe with unprecedented speed. We report a case of fulminant myocarditis associated with this virus treated successfully using extra-corporal membrane oxygenator. Case report An 18 year old previously fit and well female suffered from lethargy and malaise for six weeks combined with rigors, fever, nausea, vomiting and diarrhea over four days. After collapsing on train, she was admitted to local hospital where she was diagnosed of cardiogenic shock with echocardiogram showing severely impaired left ventricular function with ejection fraction of 20%. She was started on Dobutamine and transferred to our institution for further management. On arrival, the systolic blood pressure was 54 mmHg, sinus tachycardia of 130 per minute, tachypnea and the lactate of 13 mmol/l. The air entry was good and there were no added sounds on auscultation. She arrested shortly after arrival, was intubated and ventilated and after 65 minutes of cardiopulmonary resuscitation (CPR) a Veno- Arterial Extra corporal membrane oxygenator (VA ECMO) was inserted. The decision to put ECMO was based on need of short term circulatory support and emergency situation. The option of short term left ventricular assist device (LVAD) was not feasible as patient was being resuscitated and could not be moved in theatre for LVAD implantation. The left femoral vessels accessed percutaneously by Seldinger technique. A 17 and 21 French cannulae were inserted into Femoral artery and vein respectively and connected

Prashant Nanasaheb Mohite; Aron Frederik Popov; Armin Bartsch; Bartlomiej Zych; Dhruva Dhar; Ajay Moza; Heike Krueger; André Ruediger Simon

413

COMMENTARY Microcirculation in cardiogenic shock: from scientific bystander to therapy target

  CiteSeer

Summary: Despite diagnostic and therapeutic improvements, mortality rates in patients with cardiogenic shock remain relatively high. Several studies showed that cardiogenic shock is associated with alterations in the microvascular circulation. These alterations may be reversed by extracorporeal support devices. A study by Munsterman and colleagues adds to the body of evidence showing that in patients deemed ready for discontinuing intra-aortic balloon pump (IABP) support, microcirculatory flow in small vessels increases after ceasing IABP therapy. This study not only highlights the need for optimal timing of weaning from IABP support but also supports recent findings that global hemodynamics do not necessarily result in changes of microvascular perfusion. All modalities of modern treatment in cardiogenic shock need to be evaluated for their effect on the microcirculation. Microcirculatory evaluations should be part of randomized controlled trial protocols. More effort is needed to improve outcomes and understand the microcirculation as a therapy target and not as a silent bystander. Despite diagnostic and therapeutic improvements, cardiogenic shock (CS) is still the most common cause of death in patients with acute myocardial infarction. Although percutaneous coronary intervention (PCI), inotropes, fluids, adjunctive medication, intra-aortic balloon pump (IABP), and ventricular assist devices are widely available, mortality rates in patients with CS remain high (40 % to 50%). Therefore, Munsterman and

Christian Jung; Er Lauten; Markus Ferrari

414

unknown title

  CiteSeer

Summary: Objective: To confirm the hypothesis that psychotropic drugs, especially neuroleptics, lithium, and antidepressants, are implicated as a cause of unexpected sudden death in psychiatric patients because of their cardiotoxicity, especially when hidden cardiac lesions are present. Method: We performed a full pathological examination of 14 psychiatric patients who unexpectedly and suddenly died between 1980 and 1999. Results: Neuroleptics were involved in 13 instances, antidepressants in 9, and anxiolytics in 5. Psychotropic drugs were combined in all but a single patient. In all 14 patients, toxicological analyses discarded drug overdose as cause of death. At postmortem examination, the brain and abdominal organs were normal. In 13 patients, the following lesions were found in the heart and lungs: dilated cardio-myopathy (6 patients), left ventricular hypertrophy (2 patients, 1 of which was associated with mitral prolapse and anomalies of His bundle), arrhythmogenic cardiopathy of the right ventricle (1 patient), pericarditis (1 patient), mitral prolapse (1 patient), muscular bridge on the anterior interventricular artery (1 patient), and Mendelsons syndrome (1 patient). In 1 case, no changes were seen. Most of the drugs that were taken immediately prior to death can induce arrhythmias either by prolonging the QT interval, potentially resulting in torsades de pointes, or by widening QRS complexes, possibly leading

Dominique Frassati Md; Alain Tabib; Bernard Lachaux; Natalie Giloux; Jean Daléry; Rachel Mégard Pharmd; Louis Pierre Jenoudet; Jacques Descotes

415

in the cardiorenal syndrome

  CiteSeer

Summary: Ó The Author(s) 2011. This article is published with open access at Springerlink.com Abstract The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients with diabetes mellitus and in patients with renal failure. Through the formation of collagen crosslinks, and by interaction with the AGE-receptor, which impairs calcium handling and increases fibrosis, AGE-accumulation has pathophysiologically been associated with the development of diastolic and renal dysfunction. Interestingly, diastolic dysfunction is a frequent finding in elderly patients, diabetic patients and in patients with renal failure. Taken together, this suggests that AGEs are related to the development and progression of diastolic HF and renal failure. In this review, the role of AGEs as a possible pathophysiological factor that link the development and progression of heart and renal failure, is discussed. Finally, the role of AGE intervention as a possible treatment in HF patients will be discussed.

Heart Fail Rev; Suzan Willemsen; Jasper W. L. Hartog; M. Rebecca; Heiner-fokkema Dirk; J. Veldhuisen; Adriaan A. Voors; A. A. Voors; M. R. Heiner-fokkema
2011-01-01

416

MITOCHONDRIA IN CARDIAC MUSCLE CELLS OF THE CANARY AND SOME OTHER BIRDS

  CiteSeer

Summary: The fine structure of mitochondria from the ventricular myocardium of canaries, sparrows, zebra finches, quail, and geese has been studied. The first three of these birds have very fast heart rates, the quail being intermediate, and the goose has a relatively slow rate. The canary heart has a unique form of mitochondrion containing large, parallel arrays of zigzag or angled cristae. Other cristae, continuous with the zigzag ones and also occupying large parts of the mitochondrial volume, are named retiform because of the hexagonal network which they form, sometimes in a single plane and sometimes three dimensional. These two types of cristae appear to be interconnectible. It is possible that there is a direct functional significance in these peculiar forms, but, in any case, the relative constancy of dimensions in these arrays is probably related to specific properties of the molecules of which the cristal membrane is composed. It is also demonstrated that this membrane is composed in part of approximately 30-A particles which are believed to be protein molecules. This unusual mitochondrial morphology is not seen either in the other fast bird hearts or in the slower ones, so that there is neither a simple correlation with heart rate nor probably with the

David B. Slautterback, Ph.D.

417

Progressive cortical change during adolescence in childhood-onset schizophrenia. A longitudinal magnetic resonance imaging study

  CiteSeer

Summary: Background: Adolescence provides a window to examine regional and disease-specific late abnormal brain development in schizophrenia. Because previous data showed progressive brain ventricular enlargement for a group of adolescents with childhood-onset schizophrenia at 2-year follow-up, with no significant changes for healthy controls, we hypothesized that there would be a progressive decrease in volume in other brain tissue in these patients during adolescence. Methods: To examine cortical change, we used anatomical brain magnetic resonance imaging scans for 15 patients with childhood-onset schizophrenia (defined as onset of psychosis by age 12 years) and 34 temporally yoked, healthy adolescents at a mean (SD) age of 13.17 (2.73) years at initial baseline scan and 17.46 (2.96) years at follow-up scan. Cortical gray and white matter volumes were obtained with an automated analysis system that classifies brain tissue into gray matter, white matter, and cerebrospinal fluid and separates the cortex into anatomically defined lobar regions. Results: A significant decrease in cortical gray matter

Judith L. Rapoport; Md Jay; N. Giedd; Md Jonathan Blumenthal; Ma Susan Hamburger; Alex Zijdenbos; Phd Tomás Paus; Phd Alan Evans; Blumenthal Fernandez
1999-01-01

418

Three-dimensional structure of the flow inside the left ventricle of the human heart

  CERN Preprints

Summary: The laboratory models of the human heart left ventricle developed in the last decades gave a valuable contribution to the comprehension of the role of the fluid dynamics in the cardiac function and to support the interpretation of the data obtained in vivo. Nevertheless, some questions are still open and new ones stem from the continuous improvements in the diagnostic imaging techniques. Many of these unresolved issues are related to the three-dimensional structure of the left-ventricular flow during the cardiac cycle. In this paper we investigated in detail this aspect using a laboratory model. The ventricle was simulated by a flexible sack varying its volume in time according to a physiologically shaped law. Velocities measured during several cycles on series of parallel planes, taken from two orthogonal points of view, were combined together in order to reconstruct the phase averaged, three-dimensional velocity field. During the diastole, three main steps are recognized in the evolution of the vortical str...

Fortini, S; Espa, S; Cenedese, A
2014-01-01

419

Angiotensin-converting Enzyme Inhibition Delays Pulmonary Vascular Neointimal Formation

  CiteSeer

Summary: Primary pulmonary hypertension (PPH) is a disease characterized pathologically by pulmonary artery medial hypertrophy, adventitial thickening, and neointimal proliferation. Increasing recognition of the importance of remodeling to the pathogenesis of PPH suggests new therapeutic possibilities, but it will be necessary to (1) identify essential mediators of remodeling, and (2) demonstrate that inhibiting those mediators suppresses remodeling before new antiremodeling therapies can be considered feasible. The effect of angiotensin-converting enzyme (ACE) inhibition on pulmonary vascular remodeling was studied in a newly developed rat model in which neointimal lesions develop between 3 and 5 wk after monocrotaline injury is coupled with increased pulmonary artery blood flow after contralateral pneumonectomy. Neointimal formation was significantly suppressed at 5 wk by ACE inhibition whether it was started 10 d before or 3 wk after remodeling was initiated, although medial hypertrophy and adventitial thickening still developed. By 11 wk, the extent of neointimal formation in rats treated with ACE inhibition was similar to rats without ACE inhibition at 5 wk. Pulmonary artery pressures and right ventricular weights correlated with the extent of neointimal formation. Northern blot analysis and in situ hybridization demonstrated marked suppression of lung tropoelastin and type I procollagen gene expression in the presence of ACE inhibition. An angiotensin

Kazushige Okada; Matthew L. Bernstein; Wei Zhang; Daniel P. Schuster; Mitchell D. Botney

420

www.ipej.org 173 Review Article Quality of Life in Patients with Implantable Cardioverter

  CiteSeer

Summary: Background: The implantable cardioverter defibrillator (ICD) is a life saving device for individuals with life threatening ventricular arrhythmias. There is no doubt that it is a cost effective therapy in various congenital and acquired arrhythmogenic disorders. Nevertheless, shock delivery may be painful and frightening which causes psychological distress and deterioration of perceived quality of life. Methods: A systematic meta-analysis on studies reporting quality of life in patients implanted with ICDs was done using professional databases. Related articles and references of the relevant articles were also searched for suitable studies. Results: Thirty studies with a total of 3412 patients on implantable defibrillators were identified. Five of them were large randomised studies with a total of 1680 patients, while 25 were nonrandomised studies. Medical Outcome Study 36-item Short Form health survey (SF – 36) was the most common instrument used for assessment of quality of life. Only one of the 5 major randomised trial reported worsening of quality of life after implantation of a defibrillator. In the subgroup of patients receiving shocks, three out of the five trials reported worsening of quality

Michael Niehaus Md

421

Inhibition of Heart Calcium and Chloride Currents by Sodium Iodide Specific Attenuation in cAMP-dependent Protein Kinase-mediated Regulation

  CiteSeer

Summary: ABSTRACT The enzymes cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) regulate the activity of cardiac ion channel proteins. In this study the whole-cell arrangement of the patch clamp technique was used to examine the effect of NaI on PKA-stimulated CI- and Ca 2+ channels in isolated guinea pig ventricular myocytes. CI- currents (lcl) activated either by the 13-adrenergic agonist isoproterenol or the membrane-soluble cAMP analogue, 8-chlorphenylthio (8-CPT) cAMP, were greatly reduced in amplitude after substitution of an external solution containing 140 mM NaCI with a solution containing 140 mM NaI. This reduction was accompanied by a shift of- 7 mV in the reversal potential (E,~) for Icl and could be reversed upon return to the NaCI external solution. Inhibition of Io by NaI occurred in a concentration-dependent manner and was more pronounced for inward Io (ICs0 = 19 mM at-60 mV) than for outward Ict (ICs0 = 60 mM at +60 mV). In contrast to Icl activated by PKA, lcl activated by PKC was slightly augmented in the presence of NaI and the E,~v was found to shift by- 15 mV. Based on these data, the relative permeability of I- to C1- (Pl/Pcl) for this channel was calculated to

Kenneth B. Walsh; Kathryn J. Long

422

Manuscript received

  CiteSeer

Summary: A19-year-old male with cyanosis and clubbing was diagnosed with tetralogy of Fallot (TOF). Chest x-ray (A) showed prominent rib notching involving the left hemithorax (arrow). Major aortopulmonary collaterals (arrows) suggested by the rib notching were confirmed by a computerized tomogram (B, C, Online Video 1). Post-operatively he had pulmonary edema, secondary to these collaterals. Aortic angiogram (H, Online Video 2) showed tortuous posterior intercostal arteries eroding the lower margins of the corresponding ribs. Indirect collaterals arising from these vessels were supplying the left lung that were successfully coil embolized (I, Online Video 3). The TOF anatomy is demonstrated from D to G. Rib notching secondary to Major aortopulmonary collaterals is rare, as they do not run in the intercostal grooves (1), but when they arise from the inter costal arteries, notching of ribs could be expected as in this case. @ ? infundibular pulmonary stenosis; IVS ? interventricular septum; LA ? left atrium; LPA ? left pulmonary artery; LV ? left ventricle; PA ? pulmonary artery; RPA ? right pulmonary artery; RV ? right ventricle; VSD ? ventricular septal defect.

Ravindran Rajendran; P. Subramanian; Cardiology Sri Jayadeva
2012-01-01

423

RESEARCH Open Access Pulse Decomposition Analysis of the digital arterial pulse during hemorrhage simulation

  CiteSeer

Summary: Background: Markers of temporal changes in central blood volume are required to non-invasively detect hemorrhage and the onset of hemorrhagic shock. Recent work suggests that pulse pressure may be such a marker. A new approach to tracking blood pressure, and pulse pressure specifically is presented that is based on a new form of pulse pressure wave analysis called Pulse Decomposition Analysis (PDA). The premise of the PDA model is that the peripheral arterial pressure pulse is a superposition of five individual component pressure pulses, the first of which is due to the left ventricular ejection from the heart while the remaining component pressure pulses are reflections and re-reflections that originate from only two reflection sites within the central arteries. The hypothesis examined here is that the PDA parameter T13, the timing delay between the first and third component pulses, correlates with pulse pressure. T13 was monitored along with blood pressure, as determined by an automatic cuff and another continuous blood pressure monitor, during the course of lower body negative pressure (LBNP) sessions involving four stages,-15 mmHg,-30 mmHg,-45 mmHg, and-60 mmHg, in fifteen subjects (average age: 24.4 years, SD: 3.0 years; average height: 168.6 cm, SD: 8.0 cm; average weight: 64.0 kg, SD: 9.1 kg). Results: Statistically significant correlations between T13 and pulse pressure as well as the ability of T13 to resolve

Martin C Baruch; Darren Er Warburton; Shannon Sd Bredin; Anita Cote; David W Gerdt; Charles M Adkins

424

Shape versus size: Improved understanding of the morphology of brain structures

  CiteSeer

Summary: Abstract. Standard practice in quantitative structural neuroimaging is a segmentation into brain tissue, subcortical structures, fluid space and lesions followed by volume calculations of gross structures. On the other hand, it is evident that object characterization by size does only capture one of multiple aspects of a full structural characterization. Desirable parameters are local and global parameters like length, elongation, bending, width, complexity, bumpiness and many more. In neuroimaging research there is increasing evidence that shape analysis of brain structures provides new information which is not available by conventional volumetric measurements. This motivates development of novel morphometric analysis techniques answering clinical research questions which have been asked for a long time but which remained unanswered due to the lack of appropriate measurement tools. Challenges are the choice of biologically meaningful shape representations, robustness to noise and small perturbations, and the ability to capture the shape properties of populations that represent natural biological shape variation. This paper describes experiments with two different shape representation schemes, a finescale, global surface characterization using spherical harmonics, and a coarsely sampled medial representation (3D skeleton). Driving applications are the detection of group differences of amhygdala-hippocampal shapes in schizophrenia and the analysis of ventricular shape similarity in a mono/dizygotic twin study. The results clearly demonstrate that shape captures information on structural similarity or difference which is not accessible by volume analysis. Improved global and local structure characterization as proposed herein might help to explain pathological changes in neurodevelopment/neurodegeneration in terms of their biological meaning. 1.

Guido Gerig; Martin Styner; Martha E. Shenton; Jeffrey A. Lieberman
2001-01-01

425

open access to scientific and medical research Review

  CiteSeer

Summary: Abstract: Eating disorders are usually associated with an increased risk of premature death with a wide range of rates and causes of mortality. “Sudden death ” has been defined as the abrupt and unexpected occurrence of fatality for which no satisfactory explanation of the cause can be ascertained. In many cases of sudden death, autopsies do not clarify the main cause. Cardiovascular complications are usually involved in these deaths. The purpose of this review was to report an update of the existing literature data on the main findings with respect to sudden death in eating disorders by means of a search conducted in PubMed. The most relevant conclusion of this review seems to be that the main causes of sudden death in eating disorders are those related to cardiovascular complications. The predictive value of the increased QT interval dispersion as a marker of sudden acute ventricular arrhythmia and death has been demonstrated. Eating disorder patients with severe cardiovascular symptoms should be hospitalized. In general, with respect to sudden death in eating disorders, some findings (eg, long-term eating disorders, chronic hypokalemia, chronically low plasma albumin, and QT intervals.600 milliseconds) must be taken into account, and it must be highlighted that during refeeding, the adverse effects of hypophosphatemia include cardiac failure. Monitoring vital signs and performing electrocardiograms and serial measurements of plasma potassium are relevant during the treatment of eating disorder patients.

Beatriz Jáuregui-garrido; Ignacio Jáuregui-lobera

426

Review Chlorination Disinfection By-Products in Drinking Water and Congenital Anomalies: Review and Meta-Analyses

  CiteSeer

Summary: Objectives: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide recommendations for future studies. Data s o u r c e s a n d extraction: We included all published epidemiologic studies that evaluated a relationship between an index of DBP exposure (treatment, water source, DBP measurements, and both DBP measurements and personal characteristics) and risk of congenital anomalies. When three or more studies examined the same exposure index and congenital anomaly, we conducted a metaanalysis to obtain a summary risk estimate comparing the highest exposure group with the lowest exposure group. When five or more studies examined total trihalomethane (TTHM) exposure and a specific congenital anomaly, we conducted a meta-analysis to obtain exposure–response risk estimates per 10 µg/L TTHM. Data synthesis: For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM [17%; 95 % confidence interval (CI), 3–34] based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95 % CI, 21–107), but this was

Mark J. Nieuwenhuijsen; David Martinez; James Grellier; James Bennett; Nicky Best; Nina Iszatt; Martine Vrijheid; Mireille B. Toledano

427

Cardiac-like behavior of an insect flight muscle

  CiteSeer

Summary: The synchronous wing depressor muscles of the hawkmoth Manduca sexta undergo large amplitude motions at lengths that lie entirely on the ascending region of their twitch length–tension curve. Moreover, these muscles bear a striking functional resemblance to mammalian cardiac muscle in both the shape of their length–tension curve and in their working length range. Although operation on the ascending region of the twitch length–tension curve sacrifices maximal force, it does permit the generation of larger forces at greater strains. In the case of cardiac muscle, this mechanical behavior is critical for accommodating the increasing stresses Summary associated with greater ventricular filling. Similar characteristics in moth flight muscle suggest an analogous regulatory mechanism for skeletal muscles performing repetitive oscillatory work; the strong length dependence of force over their working length range should give the wing depressors the capacity to generate larger forces as wing stroke amplitude increases. These results support the notion that the length–tension relationship of muscle can be tuned to function in locomotor muscles. Key words: flight, strain, Manduca sexta, length–tension, muscle.

Michael S. Tu; Thomas L. Daniel
2004-01-01

428

Antagonist, PD123319, on Cardiovascular Remodelling of Aged Spontaneously Hypertensive Rats during Chronic Angiotensin II

  CiteSeer

Summary: which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cardiac AT2R expression is upregulated in the normal process of aging. In this study we determined the contribution of AT2R to chronic antihypertensive and remodelling effects of AT1R blockade in aged hypertensive rats. Adult (20 weeks) and senescent (20 months) spontaneously hypertensive rats (SHRs) were treated with either the AT1R antagonist, candesartan cilexetil (2 mg/kg/day), the AT2R antagonist, PD123319 (10 mg/kg/day), or a combination of the 2 compounds. Mean arterial pressure (MAP) and left ventricular volume were markedly decreased by candesartan cilexetil, however, simultaneous treatment with PD123319 had no additional effect on either parameter. Perivascular fibrosis was significantly reduced by candesartan cilexetil in aged animals only, and this effect was reversed by concomitant PD123319 administration. Vascular hypertrophy was reduced by candesartan cilexetil, and these effects were reversed by simultaneous PD123319. These results suggest that AT2R stimulation does not significantly influence the antihypertensive effect of chronic AT1R blockade, but plays a role in the regulation of vascular structure. The severe degree of cardiac perivascular fibrosis in senescent animals was regressed by AT1R blockade and this effect was reversed by simultaneous AT2R inhibition, demonstrating an antifibrotic role of AT2R stimulation in the aging hypertensive heart. 1.

Subtype Receptor (atr Blockade; Emma S. Jones; M. Jane Black; Robert E. Widdop
2011-01-01

429

CEREBROSPINAL FLUID RESEARCH REVIEW Open Access

  CiteSeer

Summary: The regulation of brain states by neuroactive substances distributed via the cerebrospinal fluid; a review Jan G Veening 1,2,3 * , Henk P Barendregt 3 The cerebrospinal fluid (CSF) system provides nutrients to and removes waste products from the brain. Recent findings suggest, however, that in addition, the CSF contains message molecules in the form of actively released neuroactive substances. The concentrations of these vary between locations, suggesting they are important for the changes in brain activity that underlie different brain states, and induce different sensory input and behavioral output relationships. The cranial CSF displays a rapid caudally-directed ventricular flow followed by a slower rostrally-directed subarachnoid flow (mainly towards the cribriform plate and from there into the nasal lymphatics). Thus, many brain areas are exposed to and can be influenced by substances contained in the CSF. In this review we discuss the production and flow of the CSF, including the mechanisms involved in the regulation of its composition. In addition, the available evidence for the release of neuropeptides and other neuroactive substances into the CSF is reviewed, with particular attention to the selective effects of these on distant downstream receptive brain areas. As a conclusion we suggest that (1) the flowing CSF is involved in more than just nutrient and waste control, but is also used as a broadcasting system consisting of coordinated messages to a variety of nearby and distant brain areas; (2) this special form of volume transmission underlies changes in behavioral states. Review outline

unknown authors

430

Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease A Statement for Professionals From the American Heart Association

  CiteSeer

Summary: Abstract—Obesity adversely affects cardiac function, increases the risk factors for coronary heart disease, and is an independent risk factor for cardiovascular disease. The risk of developing coronary heart disease is directly related to the concomitant burden of obesity-related risk factors. Modest weight loss can improve diastolic function and affect the entire cluster of coronary heart disease risk factors simultaneously. This statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism reviews the relationship between obesity and the cardiovas-cular system, evaluates the effect of weight loss on coronary heart disease risk factors and coronary heart disease, and provides practical weight management treatment guidelines for cardiovascular healthcare professionals. The data demonstrate that weight loss and physical activity can prevent and treat obesity-related coronary heart disease risk factors and should be considered a primary therapy for obese patients with cardiovascular disease. (Circulation. 2004; 110:2952-2967.) Key Words: AHA Scientific Statements obesity cardiovascular diseases exercise diet Obesity is an important risk factor for coronary heartdisease (CHD), ventricular dysfunction, congestive heart failure, stroke, and cardiac arrhythmias. Weight loss in obese patients can improve or prevent many of the obesity-related risk factors for CHD (ie, insulin resistance and type 2

Council On Nutrition; Physical Activity

431

CASE REPORT Open Access Persistent increase in cardiac troponin I in Fabry disease: a case report

  CiteSeer

Summary: Background: Hypertrophic cardiomyopathy is a frequent manifestation in Fabry disease (FD)- an X-linked lysosomal storage disorder caused by reduced activity of the enzyme a-galactosidase A. In FD an elevation of specific cardiac biomarkers, such as cardiac troponin I (cTNI) has been reported in case of clinical manifestation suggestive of myocardial ischemia. In diagnosing acute myocardial infarction cTNI is considered the most reliable parameter. Case Presentation: In the referred case we present a 59 years old female patient with the diagnosis of FD presenting with persistently increased cTNI level (lowest value 0.46 ng/ml, highest value 0.69 ng/ml; normal range <0.05 ng/ml) over a period of 5 months lacking cardiac clinical signs. Since renal insufficiency did not explain the degree of cTNI elevation, this was interpreted as a result of cardiac involvement in FD. Cardiac MRI showed marked left ventricular hypertrophy and focal late Gadolinium enhancement. Conclusions: Our case report demonstrates a persistent cTNI release in FD with cardiac involvement. Proving the persistence in a symptom free interval, it might be related to a direct damage of myocytes. In FD cTNI could serve as a beneficial long term parameter providing new perspectives for screening strategies. Background

Christian Tanislav; Andreas Feustel; Wolfgang Franzen; Oliver Wüsten; Christian Schneider; Frank Reichenberger; Arndt Rolfs; Nicole Sieweke

432

Medicolegal issues In the Statement of Claim, the patient

  CiteSeer

Summary: alleged that the GP had failed to correctly diagnose his condition at the consultation on 7 October 2000. According to the claim, the GP’s failure to diagnose ischaemic heart disease deprived the patient of the opportunity to be treated with thrombolytic therapy and/or other coronary interventional procedures. This failure to diagnose had caused the patient to suffer from an acute myocardial infarc-tion, complicated by the development of a left ventricular aneurysm. The claim alleged that the patient was now unable to work and required assistance with domestic duties. An expert opinion served with the Statement of Claim was critical of the GP’s standard of care. However, this opinion was based on the patient’s version of the consultation, namely that the patient had complained of epigastric, chest and left arm pains at the consulta-tion on 7 October 2000. An expert GP opinion obtained on behalf of the defen-dant GP noted that: ‘according to the

unknown authors

433

Review Article Recent Advances in the Treatment of ST-Segment Elevation

  CiteSeer

Summary: Copyright © 2012 Mun K. Hong.is is an open access article distributed under theCreative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ST-segment elevation myocardial infarction (STEMI) represents the most urgent condition for patients with coronary artery disease. Prompt diagnosis and therapy, mainly with primary angioplasty using stents, are important in improving not only acute survival but also long-term prognosis. Recent advances in angioplasty devices, including manual aspiration catheters and drug-eluting stents, and pharmacologic therapy, such as potent antiplatelet and anticoagulant agents, have signi?cantly enhanced the acute outcome for these patients. Continuing efforts to educate the public and to decrease the door-to-balloon time are essential to further improve the outcome for these high-risk patients. Future research to normalize the le ventricular function by autologous stem cell therapy may also contribute to the quality of life and longevity of the patients surviving STEMI. 1.

Myocardial Infarction; Munk Hong

434

Progress in Neurobiology 67 (2002) 451–467 Regulation of oligodendrocyte development in the vertebrate CNS

  CiteSeer

Summary: The vertebrate central nervous system (CNS) contains two major classes of macroglial cells, oligodendrocytes and astrocytes. Oligodendrocytes are responsible for the formation of myelin in the central nervous system, while the functions of astrocytes are more diverse and less well established. Recent studies have provided new insights into when, where and how these different classes of cell arise during CNS development. The founder cells of the oligodendrocyte lineage initially arise in distinct regions of the ventricular zone during early development as the result of local signals including sonic hedgehog. In the spinal cord, oligodendrocyte precursors appear to share a developmental lineage with motor neurons, although they may also develop from restricted glial precursors. Immature oligodendrocyte precursors are highly migratory. They migrate from their site of origin to developing white matter tracts using a variety of guidance cues including diffusible chemorepellents. The majority of oligodendrocyte precursor proliferation occurs in developing white matter as a result of the local expression of mitogenic signals. Oligodendrocyte precursor cell proliferation is regulated by a number of distinct growth factors that act at distinct stages in the lineage and whose activity is modulated by synergy with other molecules including chemokines. The final matching of oligodendrocyte and axon number is accomplished through a combination of local regulation of cell proliferation, differentiation and cell death. Not all oligodendrocyte precursors differentiate during development, and the adult CNS contains a significant population of precursors. Understanding the regulation of oligodendrogenesis will facilitate the use of these endogenous precursors to enhance repair in a variety of pathological conditions.

Robert H. Miller
2002-01-01

435

www.ipej.org 187 Review Article Optical Mapping Of Cardiac Arrhythmias

  CiteSeer

Summary: The concept of mapping rhythmic activation of the heart dates back to the beginning of last century, with initial descriptions of reentry in turtle hearts 1, to the first systematic mapping of sinus rhythm and then atrial flutter by Lewis et al 2. Barker et al 3 were the first to map the human heart. Initial mapping was primarily performed using single probes to record activation in different regions of the heart. The 1960’s and 70’s saw the development of computerized mapping of the human heart, e.g. in the cure of Wolf-Parkinson-White syndrome as well as in the study of Langendorff preparations 4. In fact, most of the recent advances in cardiac mapping have focused on improvements in multisite recordings within the heart, with the ability to simultaneous record electrical activation from several hundreds of sites having contributed significantly to our understanding of atrial and ventricular arrhythmias. Despite these recent advances, multisite contact mapping suffers from several limitations, including the technical problems associated with amplification, gains, sampling rates, signal-tonoise ratio, and the inability to see signals during high-voltage shocks. In addition, an intrinsic limitation of current mapping techniques is their inability to provide information about repolarization characteristics of electrically active cells, thereby limiting our ability to study

unknown authors

436

Running title: Mg Prevents Isoproterenol-Induced Acute Cardiac Dysfunction For correspondence and reprints contact:

  CiteSeer

Summary: Copyright Information Copyright © 2006 by the American Physiological Society. Page 2 of 30 Sympathetic nervous activation is a crucial compensatory mechanism in heart failure. However, excess catecholamine may induce cardiac dysfunction and ß-adrenergic desensitization. While magnesium is known to be a cardioprotective agent, its beneficial effects on acute cardiac dysfunction remain to be elucidated. We examined the effects of magnesium on left ventricular (LV) dysfunction induced by a large dose of isoproterenol (ISO) in dogs. Sixteen anesthetized dogs underwent a continuous infusion of ISO (1 Ag/kg/min) with or without a magnesium infusion (1 mg/kg/min). The dose-response to small doses of ISO (0.025-0.2 Ag/kg/min) was tested hourly. A large dose of ISO decreased LV systolic function, increased tau, and suppressed the dose-response to small doses of ISO in a time dependent manner. Magnesium significantly attenuated ISO-induced LV systolic and diastolic dysfunction, and preserved the dose-response to ISO. Serum ionized calcium significantly decreased with a large dose of ISO, but was fully maintained at baseline level with magnesium. A large dose of ISO increased serum lipid peroxide levels and serological markers of myocardial damage, which were significantly suppressed by magnesium. In conclusion, magnesium significantly attenuated excess ISO-induced acute cardiac dysfunction and ß-adrenergic desensitization. (187 words) 2

Yin-tie Jin; Naoyuki Hasebe; Tomoyuki Matsusaka; Shunsuke Natori; Takafumi Ohta; Shiro Tsuji; Kenjiro Kikuchi; Naoyuki Hasebe

437

547 Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage

  CiteSeer

Summary: The natriuretic peptide (NP) family is composed of three members: atrial, brain/ventricular and C-type NPs (ANP, BNP/VNP and CNP respectively) in tetrapods and teleostean fish, but only CNP in elasmobranch fish. In order to trace the process of divergence of the NP family in early vertebrate evolution, we attempted to detect NPs in the primitive ray-finned fish, the sturgeon (Acipenser transmontanus). Unexpectedly, we isolated four distinct NP cDNAs from the heart and brain of this chondrostean fish. The single NP from the brain was CNP, as judged from the lack of C-terminal ‘tail’ sequence extending from the intramolecular ring. Two of the three cardiac NPs were ANP and VNP, as judged by the presence of an amidation signal at its C-terminus (ANP) and a long and conserved C-terminal tail sequence (VNP) respectively. The third cardiac NP was most probably BNP because it possessed all the features characteristic of BNP including: (1) the presence of dibasic amino acids within the intramolecular ring; (2) the presence of AUUUA repeats in the 3?-untranslated region of its mRNA; (3) equivalent expression of its mRNA in the atrium and ventricle and appreciable expression in the brain. Based on the sturgeon BNP sequence, we further isolated BNP cDNA from the heart of tilapia and pufferfish for the first time in teleostean fish. Phylogenetic analysis of the precursors showed that newly

A Kawakoshi; S Hyodo; K Inoue; Y Kobayashi; Y Takei

438

Review Article Metabolic and Cardiovascular Effects of Ghrelin

  CiteSeer

Summary: Copyright © 2010 Manfredi Tesauro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized as a preprohormone and then proteolytically processed to yield a 28-amino acid peptide. This peptide was originally reported to induce growth hormone release; large evidence, however, has indicated many other physiological activities of ghrelin, including regulation of food intake and energy balance, as well as of lipid and glucose metabolism. Ghrelin receptors have been detected in the hypothalamus and the pituitary, but also in the cardiovascular system, where ghrelin exerts beneficial hemodynamic activities. Ghrelin administration acutely improves endothelial dysfunction by increasing nitric oxide bioavailability and normalizes the altered balance between endothelin-1 and nitric oxide within the vasculature of patients with metabolic syndrome. Other cardiovascular effects of ghrelin include improvement of left ventricular contractility and cardiac output, as well as reduction of arterial pressure and systemic vascular resistance. In addition, antinflammatory and antiapoptotic actions of ghrelin have been reported both in vivo and in vitro. This review summarizes the most recent findings on the metabolic and cardiovascular effects of ghrelin through GH-dependent and-independent mechanisms and the possible role of ghrelin as a therapeutic molecule for treating cardiovascular diseases. 1.

Manfredi Tesauro; Francesca Schinzari; Miriam Caramanti; Renato Lauro; Carmine Cardillo

439

REVIEW ARTICLE Epidemiology, Pathophysiology, Prognosis, and Treatment of Systolic and Diastolic Heart

  CiteSeer

Summary: Abstract: Underlying causes, risk factors, and precipitating causes of heart failure (HF) should be treated. Drugs known to precipitate or aggravate HF such as nonsteroidal antiinflammatory drugs should be stopped. Patients with HF and a low left ventricular ejection fraction (systolic heart failure) or normal ejection fraction (diastolic HF) should be treated with diuretics if fluid retention is present, with an angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker if the patient cannot tolerate an ACE inhibitor because of cough, angioneurotic edema, rash, or altered taste sen-sation, and with a beta blocker unless contraindicated. If severe systolic HF persists, an aldosterone antagonist should be added. If HF persists, isosorbide dinitrate plus hydralazine should be added. Calcium channel blockers should be avoided if systolic HF is present. Digoxin should be avoided in men and women with dia-stolic HF if sinus rhythm is present and in women with systolic HF. Digoxin should be given to men with systolic HF if symptoms persist, but the serum digoxin level should be maintained between 0.5 and 0.8 ng/mL. Key Words: heart failure, beta blockers, angiotensin-converting

Wilbert S. Aronow

440

Cocaine alters heart rate dynamics in conscious ferrets

  CiteSeer

Summary: This study was designed to test the hypothesis that cocaine intoxication induces distinctive alterations in sinus rhythm heart rate dynamics. Time-series and spectral analysis techniques were used to examine the effects of lethal doses of cocaine on heart rate variability in conscious, restrained ferrets. In all animals (n = 5), cocaine administration resulted in a marked decrease in sinus rhythm heart rate variability prior to sudden death. Heart rate variability (coefficient of variation of heart rate) just prior to death (0.018 ± 0.005) was significantly (p < 0.02) decreased compared to that at baseline prior to cocaine administration (0.061 ± 0.022). There was also a significant (p < 0.02) decrease in total spectral power prior to death compared to baseline. Transient low-frequency (0.04-0.10 Hz) oscillations in heart rate were also noted in three of the five animals following cocaine administration. There were, however, no significant changes in mean heart rate in response to cocaine. Alterations in heart rate dynamics were not seen in three saline-treated controls. Lethal effects of cocaine included ventricular arrhythmias (n = 2) and seizures (n = 3). One animal developed transient ST segment elevations that were consistent with coronary vasospasm. In conclusion, lethal doses of cocaine in the conscious ferret induce characteristic alterations in heart rate dynamics. These abnormalities (loss of

Bruce S. Stambler; James P. Morgan, Ph.D.; Joseph Mietus; George B. Moody
1991-01-01

441

Vortex formation and instability in the left ventricle

  CERN Preprints

Summary: We study the formation of the mitral vortex ring during early diastolic filling in a patient-specific left ventricle (LV) using direct numerical simulation. The geometry of the left ventricle is reconstructed from Magnetic Resonance Imaging (MRI) data of a healthy human subject. The left ventricular kinematics is modeled via a cell-based activation methodology, which is inspired by cardiac electro-physiology and yields physiologic LV wall motion. In the fluid dynamics videos, we describe in detail the three-dimensional structure of the mitral vortex ring, which is formed during early diastolic filling. The ring starts to deform as it propagates toward the apex of the heart and becomes inclined. The trailing secondary vortex tubes are formed as the result of interaction between the vortex ring and the LV wall. These vortex tubes wrap around the circumference and begin to interact with and destabilize the mitral vortex ring. At the end of diastole, the vortex ring impinges on the LV wall and the large-scale int...

Le, Trung; Coffey, Dane; Keefe, Daniel
2011-01-01

442

www.ipej.org 129

  CiteSeer

Summary: roman.laszlo/at/med.uni-tuebingen.de Key Words: Double ventricular excitation; dual atrioventricular node conduction physiology Case presentation A 44 year old man presented with recurrent symptomatic palpitations, always appearing during physical stress each with a similiar extent and never during resting periods. He also had fatigue and moderate dyspnoea during the episodes. The past medical history of the patient did not reveal any significant diseases. Findings of the attending physician including 12 lead ECG and echocardiography did not show any abnormality. As there was no electrocardiographic documentation of the episode, a 12-lead Holter evaluation was done. When the patient returned one week later, he reported of a typical episode of palpitations. The corresponding extract of the Holter ECG is shown in figure 1. In synopsis of the findings we saw the indication for an invasive electrophysiology study due to a documented paroxysmal narrow complex tachycardia with alternating R-R intervals coming along with symptomatic palpitations. An octapolar catheter was placed in the coronary sinus with distal and proximal pair of

unknown authors

443

Blockade of current through single calcium channels by Cd 2? , Mg 2? , and Ca 2? . Voltage and concentration dependence of calcium entry into the

  CiteSeer

Summary: and other multivalent ions on single Ca channel currents in cell-attached patch recordings from guinea pig ventricular cells. External Cd or Mg ions chopped long-lasting unitary Ba currents promoted by the Ca agonist Bay K 8644 into bursts of brief openings. The bursts appear to arise from discrete blocking and unblocking transitions. A simple reaction between a blocking ion and an open channel was suggested by the kinetics of the bursts: open and closed times within a burst were exponentially distributed, the blocking rate varied linearly with the concentration of blocking ion, and the unblocking rate was more or less independent ofthe blocker concentration. Other kinetic features suggested that both Cd 2 ' and Mg ` lodge within the pore. The unblocking rate was speeded by membrane hyperpolarization or by raising the Ba concentration, as if blocking ions were swept into the myoplasm by the applied electric field or by repulsive interaction with Ba t+. Ca ions reduced the amplitude of unitary Ba currents (50 % inhibition at ^-10 mM [Ca]o with 50 mM [Ba]o) without detectable flicker, presumably because Ca ions exit the pore very rapidly

Jeffry B Lansman; Peter Hess; Richard W Tsien
1986-01-01

444

Effects via Modification of Surface Potential

  CiteSeer

Summary: ABSTRACT Modulation of voltage-dependent sodium and potassium currents by charged amphiphiles was investigated in cardiac ventricular myocytes using the patch-clamp technique. Negatively charged sodium dodecylsulfate (SDS) increased amplitude oflNa, whereas positively charged dodecyltrimethylammonium (DDTMA) decreased INa. Furthermore, SDS shifted the steady-state activation and inactivation of INa in the negative direction, whereas DDTMA shifted the curves in the opposite direction. These shifts provided an explanation for the changes in current amplitude. Activation and inactivation kinetics of IN ~ were accelerated by SDS but slowed by DDTMA. These changes in both steady-state gating and kinetics oflN ~ are consistent with a decrease of the intramembrane field by SDS and an increase of the field by DDTMA due to an alteration of surface potential after their insertion into the outer monolayer of the sarcolemma. The effect of SDS on the steady-state inactivation OflN ~ was concentration dependent and partially reversed by screening surface charges with increased extracellular [Ca~+]. These amphiphiles also altered the activation of the delayed rectifier K ÷ current (Ir~dd), producing a shift in the negative direction by SDS but in the positive direction by DDTMA. These results suggest that the insertion of charged amphiphiles into the cell membrane alters the behavior of voltage-dependent IN ~ and Ir~del by changing the surface charge density, and consequently the surface potential and implies, although indirectly, that the lipid surface charges are important to the voltage-dependent gating of these channels.

Sen Ji; James N. Weiss; Glenn A. I_atnger

445

Mechanisms of Na +-Ca 2+ Exchange Inhibition by Amphiphiles in Cardiac Myocytes: Importance of Transbilayer Movement

  CiteSeer

Summary: Abstract. The membrane lipid environment and lipid signaling pathways are potentially involved in the modulation of the activity of the cardiac Na +-Ca 2+ exchanger (NCX). In the present study biophysical mechanisms of interactions of amphiphiles with the NCX and the functional consequences were examined. For this purpose, intracellular Ca 2+ concentration jumps were generated by laser-flash photolysis of caged Ca 2+ in guinea-pig ventricular myocytes and Na +-Ca 2+ exchange currents (INa/Ca) were recorded in the whole-cell configuration of the patchclamp technique. The inhibitory effect of amphiphiles increased with the length of the aliphatic chain between C7 and C10 and was more potent with cationic or anionic head groups than with uncharged head groups. Long-chain cationic amines (C 12) exhibited a cut-off in their efficacy in I Na/Ca inhibition. Analysis of the time-course, comparison with the Ni 2+-induced INa/Ca block and confocal laser scanning microscopy experiments with fluorescent lipid analogs (C6- and C12-NBD-labeled analogs) suggested that amphiphiles need to be incorporated into the membrane. Furthermore, NCX block appears to require transbilayer movement of the amphiphile to the inner leaflet (‘‘flip’’). We conclude that both, hydrophobic and electrostatic interactions between the lipids and the NCX may be important factors for the modulation by lipids and could be relevant in cardiac diseases where the lipid metabolism is altered. Key words: Sodium-calcium exchange — Cardiac myocyte — Caged calcium — Excitation-contraction

M. Keller; C. Pignier; E. Niggli; M. Egger
2003-01-01

446

LETTER TO THE EDITORS Noninvasive imaging in the diagnosis of acute viral myocarditis

  CiteSeer

Summary: Ó The Author(s) 2010. This article is published with open access at Springerlink.com Authors ’ reply We hereby respond to the comments of M. Gutberlet and H. Thiele to our review [1]. The first comment pertains to the assessment of pericardial effusion. A steady-state-free precession sequence (SSFP) is the basis of every myocardial examination and therefore should be used in every cardiac patient when evaluating left ventricular function and dimensions, 2, 3 and 4-chamber long-axis views, and 3-D short-axis volume, hence in every patient with pericardial effusion. T1- and T2-weighted images are additional sequences, useful in this patient cohort. The next topic addresses simple ‘‘eye-balling’ ’ in myocarditis. It was our intention to explain to the reader that a profound assessment of a proposed myocardial edema by modern sequences, such as a ‘‘STIR’ ’ sequence, a special T2-weighted image, must be followed by a thorough analysis. As stated in our review, the ratio of global myocardial signal intensity/muscle signal (global T2 ratio) intensity should be determined. This technique was introduced by Friedrich et al. [2] and used by Gutberlet et al. [3] and our group [4]. We discussed this technique and the published papers in detail in the ‘‘T2-weighted images’’ section, and, thus, do not understand the comments of Gutblerlet et al. In Fig. 1 of our review, that patient’s global T2 ratio was profoundly enhanced, indicating myocardial edema. This was an example of globally diffuse edema, not regional edema, as stated by M. Gutberlet and H. Thiele. Gutberlet and Thiel’s image 1 depicts a regional

Michael Jeserich; M. Jeserich
2010-01-01

447

Culture-Modified Bone Marrow Cells Attenuate Cardiac and Renal Injury in a Chronic Kidney Disease Rat Model via a Novel Antifibrotic Mechanism

  CiteSeer

Summary: Background: Most forms of chronic kidney disease are characterized by progressive renal and cardiac fibrosis leading to dysfunction. Preliminary evidence suggests that various bone marrow-derived cell populations have antifibrotic effects. In exploring the therapeutic potential of bone marrow derived cells in chronic cardio-renal disease, we examined the antifibrotic effects of bone marrow-derived culture modified cells (CMCs) and stromal cells (SCs). Methodology/Principal Findings: In vitro, CMC-conditioned medium, but not SC-conditioned medium, inhibited fibroblast collagen production and cell signalling in response to transforming growth factor-ß. The antifibrotic effects of CMCs and SCs were then evaluated in the 5/6 nephrectomy model of chronic cardio-renal disease. While intravascular infusion of 10 6 SCs had no effect, 10 6 CMCs reduced renal fibrosis compared to saline in the glomeruli (glomerulosclerosis index: 0.860.1 v 1.960.2 arbitrary units) and the tubulointersitium ( % area type IV collagen: 1.260.3 v 8.462.0, p,0.05 for both). Similarly, 10 6 CMCs reduced cardiac fibrosis compared to saline ( % area stained with picrosirius red: 3.260.3 v 5.160.4, p,0.05), whereas 10 6 SCs had no effect. Structural changes induced by CMC therapy were accompanied by improved function, as reflected by reductions in plasma creatinine (5863 v 81611 mmol/L), urinary protein excretion (96/41 v 646/41 mg/day), and diastolic cardiac stiffness (left ventricular end-diastolic pressure-volume relationship: 0.03060.003 v 0.05860.011 mm

Darren A. Yuen; Kim A. Connelly; Andrew Advani; Christine Liao; Michael A. Kuliszewski; Kerri Thai; Suzanne L. Advani; Yuan Zhang; Darren J. Kelly; Howard Leong-poi

448

Four-Chamber Heart Modeling and Automatic Segmentation for 3D Cardiac CT Volumes Using Marginal Space Learning and Steerable Features

  CiteSeer

Summary: We propose an automatic four-chamber heart segmentation system for the quantitative functional analysis of the heart from cardiac computed tomography (CT) volumes. Two topics are discussed: heart modeling and automatic model fitting to an unseen volume. Heart modeling is a non-trivial task since the heart is a complex nonrigid organ. The model must be anatomically accurate, allow manual editing, and provide sufficient information to guide automatic detection and segmentation. Unlike previous work, we explicitly represent important landmarks (such as the valves and the ventricular septum cusps) among the control points of the model. The control points can be detected reliably to guide the automatic model fitting process. Using this model, we develop an efficient and robust approach for automatic heart chamber segmentation in 3D CT volumes. We formulate the segmentation as a two-step learning problem: anatomical structure localization and boundary delineation. In both steps, we exploit the recent advances in learning discriminative models. A novel algorithm, marginal space learning (MSL), is introduced to solve the 9-dimensional similarity transformation search problem for localizing the heart chambers. After determining the pose of the heart chambers, we estimate the 3D shape through learning-based boundary delineation. The proposed method has been extensively tested on the largest dataset (with 323 volumes from 137 patients) ever reported in the literature. To the best of our knowledge, our system is the fastest with a speed of 4.0 seconds per volume (on a dual-core 3.2 GHz processor) for the automatic segmentation of all four chambers.

Yefeng Zheng; Adrian Barbu; Bogdan Georgescu; Michael Scheuering; Dorin Comaniciu
2008-01-01

449

Assessment of mitral bioprostheses using cardiovascular magnetic resonance Open Access

  CiteSeer

Summary: Background: The orifice area of mitral bioprostheses provides important information regarding their hemodynamic performance. It is usually calculated by transthoracic echocardiography (TTE), however, accurate and reproducible determination may be challenging. Cardiovascular magnetic resonance (CMR) has been proven as an accurate alternative for assessing aortic bioprostheses. However, whether CMR can be similarly applied for bioprostheses in the mitral position, particularly in the presence of frequently coincident arrhythmias, is unclear. The aim of the study is to test the feasibility of CMR to evaluate the orifice area of mitral bioprostheses. Methods: CMR planimetry was performed in 18 consecutive patients with mitral bioprostheses (n = 13 Hancock ®, n = 4 Labcore ®, n = 1 Perimount ®; mean time since implantation 4.5 ± 3.9 years) in an imaging plane perpendicular to the transprosthetic flow using steady-state free-precession cine imaging under breath-hold conditions on a 1.5T MR system. CMR results were compared with pressure half-time derived orifice areas obtained by TTE. Results: Six subjects were in sinus rhythm, 11 in atrial fibrillation, and 1 exhibited frequent ventricular extrasystoles. CMR image quality was rated as good in 10, moderate in 6, and significantly impaired in 2 subjects. In one prosthetic type (Perimount®), strong stent artifacts occurred. Orifice areas by CMR (mean 2.1 ± 0.3 cm2) and TTE (mean 2.1 ± 0.3 cm2) correlated significantly (r = 0.94; p < 0.001). Bland-Altman analysis showed a 95 % confidence interval from-0.16 to

Florian Von Knobelsdorff-brenkenhoff; André Rudolph; Ralf Wassmuth; Jeanette Schulz-menger
2010-01-01

450

peptides in stable patients with systolic heart failure ” by Rosenberg et al.

  CiteSeer

Summary: During the last decades, the pharmacotherapy of heart failure (HF) has changed dramatically. Large-scale trials have been conducted that have indisputably shown the efficacy of angiotensin-converting enzyme inhibitors (ACE-I) and betaadrenergic receptor blockers (?-blockers). These and other therapies have improved the overall outcome of patients with HF, although prognosis remains bleak. To identify patients with high risk for suffering a cardiovascular event or death, numerous (bio)markers have been put to test. (Serial) B-type natriuretic peptide (BNP) has emerged as a powerful surrogate parameter to monitor the severity of heart failure [1]. BNP can be measured easily and reliably [2] and currently, BNP is generally accepted as one of the strongest predictors for future events, death, and its use is advocated to monitor treatment [1]. In order for us to use BNP as a surrogate parameter at the full range of HF patients, we need to understand how BNP is regulated and what effects different drugs exert on BNP expression, production, and release. BNP is expressed by ventricular, and to a lesser extent, atrial cardiomyocytes upon stretch [1]. On a clinical level, this is paralleled by mRNA levels that are directly related to parameters of severity of HF and to LV geometry [3]. On a molecular level, angiotensin II directly increases mRNA levels of BNP via posttranscriptional control of BNP [4, 5]. This in part mediated by a GATA element in the BNP promoter [6]. GATA elements are necessary and sufficient to confer transcriptional activation of BNP gene in response R. A. de Boer: D. J. van Veldhuisen (*)

Rudolf A. De Boer; Dirk J. Van Veldhuisen
2008-01-01

451

A Randomized Trial of Exercise Training in Patients With Coronary Heart Disease

  CiteSeer

Summary: In order to determine whether or not regular exercise could alter myocardial perfusion or function, we randomized 146 male volunteers with stable coronary heart disease to either a supervised exercise program (n=72) or to a usual care program (n=74). Subjects underwent exercise tests initially and one year later. Significant differences between the two groups included improved aerobic capacity, thallium ischemia scores, and ventricu-lar function in the exercise intervention group. It was not possible to classify the conditions of patients as to the likelihood of improvement or deteriora-tion. This study demonstrated changes in myocardial perfusion and function in a select group of middle-aged men with coronary heart disease who underwent a medically appropriate exercise program lasting one year, but these changes were relatively modest. (JAMA 1984;252:1291-1297) THE USE of exercise training in the treatment of patients with coronary heart disease has gained widespread acceptance because of the many potential beneficial physiological and psychological adaptations.1 These in¬ clude decreased symptoms, increased functional capacity, and improved psychological well-being. However, attempts to define the mechanisms of the physiological changes have yielded conflicting results. While many animal studies have shown favorable cardiac changes to be induced by exercise training,2 studies in humans have attributed most of the beneficial changes in patients with coronary heart disease to pe¬ ripheral adaptations.3,4 In 1979, a National Heart, Lung, and Blood Institute workshop concluded that there existed a need for continued research using small randomized studies to further clarify the value of physical training ' because larger trials using morbidity and mortality end points have been inconclusive.6,7 In response to this, we proposed a

unknown authors

452

THE EFFECT OF LANATOSIDE-C ON THE RESPONSE OF THE HUMAN CARDIAC OUTPUT TO WALKING EXERCISE

  CiteSeer

Summary: When the possibility of heart failure is anticipated in the human subject during exercise, or during some other form of circulatory stress such as a surgical operation, the chance of benefit from the administration of digitalis must be weighed against the probability of circulatory impairment by the drug if no heart failure appears-a probability which has been suggested by prior clinical observations, ' and by physiological studies in resting human subjects free of heart failure." " Ue1 However, the changes of cardiac output caused by digitalis at rest may not necessarily indicate what effects the drug will have on the stressed circulation. In the normal dog, for instance, the resting systemic blood flow is reduced7 by a dose of cardiac glycoside which increases ventricular contractility, ' and which improves the output of the heart working under an increased pressure or flow load. ' It is apparent that the effect of digitalis on circulatory competence is best measured by a change of cardiac output when the heart is operating near the limit of its capacity, or when the adequacy of the output may be expressed in terms of concomitant peripheral circulatory demands. The present investigation was prompted by the need for more definitive information regarding the effect of cardiac glycosides on the normal human circulation under stress. With the aforementioned considerations in mind, it was proposed to evaluate the effect of Lanatoside-C on the circulatory response to some form of exercise commonly required of the human subject. For this purpose, it was of paramount importance to choose the proper type and degree of exercise with which to challenge the circulation, as well as the most suitable measurements by which to evaluate the circulatory response.

Allan V. N. Goodyer; Andrew Huvosf

Some links on this page may take you to non-federal websites. Their policies may differ from this site.