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Sample search results for: a-type gaba receptor

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1 Stimulating electrode AMPA receptor
 

Summary:  2,3-dione Glutamate Glu GABA NMDA AMPA Na+ Na+ & Ca++ K+ Stimulating electrode AMPA receptor: NMDA... receptor: Agonist = N-methyl-D-Aspartate Agonist = AMPA GluGABA Cl- GABAA Interneuron GABAB GABA A receptor... GABAB receptor Agonist = ...

  

Source: Hasselmo, Michael - Department of Psychology & Computational Neurophysiology Laboratory, Boston University

 

Collection: Biology and Medicine

 
2 Calcium Influx through NMDA Receptors Directly Evokes GABA Release in Olfactory Bulb Granule Cells
 

Summary:  Calcium Influx through NMDA Receptors Directly Evokes GABA Release in Olfactory Bulb Granule Cells... -Na extracellular solutions, we show that endogenous glutamate can elicit GABA release via both NMDA receptor... --and docked vesicles containing GABA raises the pos- sibility that the ...

  

Source: Strowbridge, Ben - Department of Neurosciences, Case Western Reserve University

 

Collection: Biology and Medicine

 
3 Br. J. Pharmacol. (1990), 100, 807-813 Differential effects of petit mal anticonvulsants and convulsants
 

Summary:  acts as a partial agonist at the picrotoxin GABA-blocking receptor. 4 MPS had no effect on GABA... are thought to bind to the picrotoxin receptor in the GABA receptor/ionophore complex (Klunk et al., 1982a... Author for correspondence. appeared to act as a partial ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
4 Neuropharmacology 41 (2001) 539545 www.elsevier.com/locate/neuropharm
 

Summary:  receptor it was inferred that diazepam increases the affinity for GABA at only one of the two GABA binding... of the receptor that is distinct from the resting and GABA-activated states (Williams and Akabas, 2000). During... of GABA or diazepam on subsequent ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
5 Acute neurosteroid modulation and subunit isolation of the -aminobutyric acidA receptor in the bullfrog,
 

Summary:  acid (GABA) has multiple receptors. In mammals, the GABAA receptor subtype is modulated... neurotransmitter, -aminobutyric acid (GABA), to the GABAA receptor. In mammals, radioligand binding studies... . 2000). GABA, via the GABAA receptor, alters ...

  

Source: Boyd, Sunny K. - Department of Biological Sciences, University of Notre Dame

 

Collection: Biology and Medicine

 
6 Fax +41 61 306 12 34 E-Mail karger@karger.ch
 

Summary:  ­07;15:13­25 DOI: 10.1159/000094384 An Ionotropic GABA Receptor with Novel Pharmacology at Bullfrog Cone... receptor is more sensitive to GABA than the GABAA receptor [9­12], and currents mediated by these two types... of GABA receptors are ...

  

Source: Liu, Jian - Harvard University

 

Collection: Biology and Medicine

 
7 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  (2009) GABA-A Receptors: Developmental Roles. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 4... , pp. 453-461. Oxford: Academic Press. #12;GABA-A Receptors: Developmental Roles Y Ben-Ari, Universite... Development The activation of GABA receptors leads to ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
8 Ionotropic GABA Receptor From Lobster Olfactory Projection A. B. ZHAINAZAROV,1
 

Summary:  Ionotropic GABA Receptor From Lobster Olfactory Projection Neurons A. B. ZHAINAZAROV,1 M. WACHOWIAK... and B. W. Ache. Ionotropic GABA receptor from lobster olfactory additional diversity within these two... GABA receptors, for example, can occur study reports an ...

  

Source: Boettcher, Anne - Department of Biology, University of South Alabama

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
9 Regional differences in GABA and GAD immunoreactivity in rabbit horizontal cells
 

Summary:  ), and their terminals are presynaptic to GABA receptors. In adult rabbit, however, GABA and GAD immunoreactivity have... -5238098 $12.50 743 #12;cells. This is because GABA receptors are localized to bipolar dendritic tips... that the enzyme ac- tually synthesizes ...

  

Source: Pennsylvania, University of - Department of Neuroscience, Retina Group

 

Collection: Biology and Medicine

 
10 Brain Research 954 (2002) 6872 www.elsevier.com/locate/bres
 

Summary:  in GABA receptor binding in layer IV of adultA primate somatosensory cortex after peripheral nerve injury... in GABA and GABA receptor binding in primate somatosensory cortexA B following peripheral nerve injury... . Here we report reductions in GABA ...

  

Source: Wellman, Cara - Department of Psychological and Brain Sciences, Indiana University

 

Collection: Biology and Medicine

 
11 Slow Desensitization Regulates the Availability of Synaptic GABAA Receptors
 

Summary:  and postsynaptic receptors. We report here that low concentrations of GABA reduce IPSCs in hippocampal neurons... of channels in this ab- sorbing state allows GABAA receptors to detect even a few molecules of GABA... receptor desensitization in response to endogenously released ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
12 INMED/TINS special issue Trophic actions of GABA on neuronal
 

Summary:  in association with various trophic factors. Thus, GABA or the GABA receptor agonist muscimol inhibits... , decrease GABA production [1] and GABAA receptor expression [5], providing a feedback signal to control cell... act on GABA receptors. These ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
13 728 | SEPTEMBER 2002 | VOLUME 3 www.nature.com/reviews/neuro R E V I E W S
 

Summary:  , and GABA is excitatory in mice that lack KCC2. Third, the activation or blockade of GABAA receptors alters... Metazoan phylum,has GABAB receptors that are similar to mammalian metabotropic receptors118 . GABA operates... of chloride when chloride-permeable channels,such as ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
14 Mapping the Agonist Binding Site of the GABAA Receptor: Evidence for a -Strand
 

Summary:  1 Y59 to S68 is a -strand. Key words: GABA; GABAA receptor; binding site; substituted cysteine... ., 1997; Barnard et al., 1998). The binding of GABA to GABAA receptors promotes conformational changes... be propagated to distant parts of the receptor. To understand the transduction of ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
15 Cellular/Molecular An Arginine Involved in GABA Binding and Unbinding But
 

Summary:  receptor plays in channel function. This residue is likely to face into the GABA-binding pocket, and its... desensitization. A, B, 1 2 or 1 2-R207C receptors were challenged with 2 msec (A) or 1 sec (B) pulses of GABA. All... , squares) and mutant (dashed lines, circles) receptors for 1 ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
16 Decreased Benzodiazepine Binding with Little Effect on -Aminobutyric Acid Binding in Rat Brain After Treatment
 

Summary:  , GABA binding site and TBPS site (associated with the ion channel domain of the receptor... of benzodiazepines to bind to a GABAA receptor and to increase the GABA-dependent gating of the intrinsic Cl channel... the other binding sites present on GABAA receptors. Indeed, the ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
17 Proc. Nati. Acad. Sci. USA Vol. 82, pp. 2168-2172, April 1985
 

Summary:  chro- maffin cells by using patch-clamp techniques. These channels share many properties with GABA-receptor... of 2 in the Hill plot, indicating a bimolecular bind- ing reaction of GABA to the receptor. Single... ]muscimol, a potent GABA receptor agonist, and for [3H]flunitrazepam, a ...

  

Source: Clapham, David E. - Department of Neurobiology, Harvard University

 

Collection: Biology and Medicine

 
18 Individually Monitoring Ligand-Induced Changes in the Structure of the GABAA Receptor at Benzodiazepine
 

Summary:  and benzodiazepine (BZD) binding sites of the GABA-A receptor are allosterically coupled remain elusive... ., 2001; Rudolph and Mohler, 2004). BZDs exert their effects by binding to the GABA-A receptor... . The GABA-A receptor mediates the majority of synaptic ...

  

Source: Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
19 Individually Monitoring Ligand-Induced Changes in the Structure of the GABAA Receptor at Benzodiazepine
 

Summary:  and benzodiazepine (BZD) binding sites of the GABA-A receptor are allosterically coupled remain elusive... ., 2001; Rudolph and Mohler, 2004). BZDs exert their effects by binding to the GABA-A receptor... . The GABA-A receptor mediates the majority of synaptic ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
20 Neuroscience Letters, 89 (1988) 335 341 335 Elsevier Scientific Publishers Ireland Ltd.
 

Summary:  was used to study the development of functional GABA receptors m cortical neurons dissociated from... that it was mediated by GABAA receptors. GABA receptors are thus present and functional very early in corticogenesis... receptors is at least partially responsible ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine


Page:   2  3  4  5 
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21 Evidence That Certain Retinal Bipolar Cells Use Both Glutamate and GABA
 

Summary:  with GABA, VGAT, VGLUT1, glutamate, G o, and neurokinin 3 receptor (NK3-R), the primary antibody against GAD... and then injected with DiI to reveal their complete morphology. A: Type I restricted its axon arbor to stratum 1... . 2000. Pharmacology of GABA(A) ...

  

Source: Pennsylvania, University of - Department of Neuroscience, Retina Group

 

Collection: Biology and Medicine

 
22 Benzodiazepines Induce a Conformational Change in the Region of the -Aminobutyric Acid Type A Receptor
 

Summary:  ) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA... . The -aminobutyric acid (GABA) type A (GABAA) receptors are the molecular targets for these clinical effects. GABAA... . ABBREVIATIONS: GABA, -aminobutyric acid; ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
23 Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
 

Summary:  glutamate receptors assemble into strict dimers, the GABA receptor spontaneously form dimers of heterodimers... ; Protein Structure, Quaternary ; Receptors, G-Protein-Coupled ; metabolism ; Receptors, GABA-B ; chemistry... ; GABA Cell-cell ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
24 Mapping convulsants' binding to the GABA-A receptor chloride ionophore: A proposed model for channel binding sites
 

Summary:  Mapping convulsants' binding to the GABA-A receptor chloride ionophore: A proposed model... Abstract Gamma-aminobutyric acid (GABA) type A receptors play a key role in brain inhibitory... (5-HT3) and N-acetylcholine receptors by GABA-A channel blockers, and examine ...

  

Source: Kalueff, Allan V. - Department of Pharmacology, Tulane University

 

Collection: Biology and Medicine

 
25 Neuropharmacology 37 (1998) 199205 Amphetamine releases GABA in striatum of the freely moving rat
 

Summary:  , a D1­D2 receptor antagonist, blocked the release of GABA in striatum produced by intraperitoneal... -independent transporter- mediated release of GABA probably acting on neu- ronal and/or glial glutamatergic receptors. Also... . Dopamine receptor antagonist blocks the release of glycine, ...

  

Source: Askari, Amir - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
26 [Book Title], Edited by [Editor's Name]. ISBN 0-471-XXXXX-X Copyright 2000 Wiley[Imprint], Inc.
 

Summary:  seizure occurrence by prolonging the exposure of postsynaptic receptors to GABA, thus prolonging... of GABAA receptors and GABA transporters. #12;Wiley STM / Editor: Book Title, Chapter 17 / Overstreet... blockers nor of GABA itself were prevented by GABAB receptor ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
27 Defining the Propofol Binding Site Location on the GABAA Moez Bali and Myles H. Akabas
 

Summary:  and presence of GABA. Because propofol binding induces conformational change in the GABAA receptor, we needed... effects on GABAA receptors are concentration-dependent. At low concentrations, GABA- active anesthetics... of GABA separated by at least 4 Fig. 1. Homology model structure of ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
28 Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation
 

Summary:  209, suggesting that the binding site may constrict during gating. Key words: GABA; GABAA receptor... not shown). GABA dose­response analysis of the mutant receptors revealed six residues that cause shifts... of the receptor by pentobar- bital (Table 1). Notably, the mutations that ...

  

Source: Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
29 HPLC conditions are critical for the detection of GABA by microdialysis HPLC conditions are critical for the detection of
 

Summary:  .C. (1990) Investigations on GABAB receptor- mediated autoinhibition of GABA release. Naunyn Schmiedebergs... decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283... -119. Fraser D.D., Mudrick-Donnon L.A., Macvicar B.A. (1994) Astrocytic ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 JOURNALOFNEUROPHYSIOLOGY RAPID PUBLICATIONVol. 71, No. 6, June 1994. Printedin U.S.A. Clonazepam SuppressesGABA,-Mediated Inhibition in Thalamic
 

Summary:  ,)- and GABA,-receptor-mediated components that hyperpolarize the postsynaptic neurons and deinactivate... - man petit ma1 epilepsy (Penry and So 1981)) presumably by enhancing GABA,-receptor-mediated inhibition... of activation of fewer GABA, receptors, and not due to shunting of the synaptic current. The ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
31 Agonist-, Antagonist-, and Benzodiazepine-Induced Structural Changes in the 1Met113
 

Summary:  , the protein movements underlying GABA-induced channel acti- vation and BZD-mediated receptor modulation... to the GABAA receptor induces conformational rearrangements in the GABA binding site, providing structural... Materials and Methods). GABA activated wild-type ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
32 164 Current Literature in Basic Science A THALAMIC SLEEP TONIC
 

Summary:  the sensitivity of extrasynaptic GABA receptors and thus, increase their openings in response to ambient GABA... from localized synapses spreads to extrasynaptic receptors on that particular dendrite. GABA might even... the extrasynaptic receptors, whereas phasic ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
33 TheJournalofGeneralPhysiology J. Gen. Physiol. The Rockefeller University Press $15.00
 

Summary:  of GABA did not alter the fluorescence intensity of site- specific fluorescent-labeled GABA receptors... ' position in 1V257C12 receptors, inhibiting subsequent GABA-induced currents, whereas cationic reagents did... receptors. Application of 2 mM MTSET+ for 150 s in ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
34 Molecular Human Reproduction vol.3 no.8 pp. 677683, 1997 -Aminobutyric acid (GABA) induces the acrosome reaction in
 

Summary:  acid (GABA) type A-like receptor. Although there is direct evidence of GABA initiation of mouse sperm... . Evidence has been presented showing that GABA and muscimol, two GABA receptor agonists, can induce... have GABAA receptors on the cell ...

  

Source: Museo Nacional de Ciencias Naturales - Madrid, Reproductive Ecology and Biology Group

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
35 Functional and Structural Analysis of the GABAA Receptor 1 Subunit during Channel Gating and Alcohol Modulation*
 

Summary:  examined. GABA-induced currents in Xenopus oocytes expressing wild type and cysteine mutant GABAA receptors... site-directed mu- tagenesis in pGEMHE plasmid encoding the rat GABA receptor 1 subunit and a Quik... to GABAA receptors, GABA control currents were first ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
36 Structural Evidence that Propofol Stabilizes Different GABAA Receptor States at Potentiating and Activating Concentrations
 

Summary:  - epine; isoflurane; ethanol The GABA type A (GABAA) receptor is an allosteric inhibitory neurotransmitter... directly activates receptors, caus- ing channel opening in the absence of GABA (Sanna et al., 1995; Lam... GABA cur- rents, they have different effects on GABAA ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
37 Shunting and Hyperpolarizing GABAergic Inhibition in the High-Potassium Model of Ictogenesis
 

Summary:  in vitro were compared with the effect of GABA(A)-receptors antagonists and GABA(A) modulators on high... , activation of GABA(A) receptors pro- duced an isoelectric, purely shunting response characterized... , GABA(A)-receptor antagonists did not affect the occurrence of ictal dis- ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
38 Research Report Characterization of the binding of [3
 

Summary:  neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABAA) and metabotropic (GABAB) receptors... ., 1988). Mammalian receptors for GABA occur in two subclasses (Simeone et al., 2003). The GABAA receptor... of putative GABAB receptors has been ...

  

Source: Boyd, Sunny K. - Department of Biological Sciences, University of Notre Dame

 

Collection: Biology and Medicine

 
39 New Encyclopedia of Neuroscience -CONTRIBUTORS' INSTRUCTIONS PROOFREADING
 

Summary:  Excitatory/Inhibitory Shift of GABA Actions during Development p0015The activation of GABA receptors leads... receptors and NMDA receptors that is quite opposite to the actions of GABA in adult neurons has important... , applications of GABA ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
40 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  of the NR1 subunit, enhances AMPA currents, and modulates GABA currents. Because D1-like receptor regu... to as the fast A-type current (IA) because it shows fast inactivation kinetics (around 12 msec at À10 mV). IKS... , also referred to as ID, IAs, or the slow A-type current, is the slowly inactivating ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
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41 Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus
 

Summary:  . The GABA(A) receptor agonist isoguvacine increased ®ring of CA3 pyramidal cells in neonatal slices while... at P11.3 Æ 0.4), but only interictal activity before and after that age. The GABA(A) receptor... ; Baram et al., 1997) and GABA(B) receptor antagonists ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
42 EPC epc270 Dispatch: June 23, 2008 CE: PEK Journal MSP No. No. of pages: 3 PE: Cindy
 

Summary:  . Here we show that autocrine/paracrine -aminobutyric acid (GABA) signalling by means of GABAA receptors... their action by GABA receptors and are used during pregnancy by women with epilepsy. Epilepsy Currents, Vol. 8... 42 43 44 45 46 47 48 49 50 51 52 53 CURRENT LITERATURE IN BASIC SCIENCE ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
43 Local and Global Ligand-Induced Changes in the Structure of the GABAA Yukiko Muroi, Cynthia Czajkowski, and Meyer B. Jackson*
 

Summary:  to these parts of the protein. Applying GABA along with competitive and noncompetitive GABAA receptor antagonists... of these residues change polarity when the receptor is activated by GABA. According to this interpretation, R1L127 2... of GABA applied to R1 2 ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
44 Local and Global Ligand-Induced Changes in the Structure of the GABAA Yukiko Muroi, Cynthia Czajkowski, and Meyer B. Jackson*
 

Summary:  . Applying GABA along with competitive and noncompetitive GABAA receptor antagonists indicated that different... of these residues change polarity when the receptor is activated by GABA. According to this interpretation, R1L127 2... of GABA applied to R1 2 receptors ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
45 Research report Characterization of the GABAA receptor in the brain of the
 

Summary:  : Neurotransmitters, modulators, transporters, and receptors Topic: GABA receptors Keywords: Amphibian; Bicuculline... in the quail brain as in the rat brain [15]. GABA binding to the GABAA receptor plays important roles... ]flunitrazepam binding and func- tional studies support the ...

  

Source: Boyd, Sunny K. - Department of Biological Sciences, University of Notre Dame

 

Collection: Biology and Medicine

 
46 2005 Nature Publishing Group GABA (-aminobutyric acid) is the main inhibitory
 

Summary:  -mediated signalling. In recent years, it has become evident that GABA receptor activation can also take place... discuss how factors such as GABAA receptor heterogeneity,receptor localization and the GABA concentration... hundred)1­4 .These receptors experience a ...

  

Source: Sandini, Giulio - Dipartimento di Informatica Sistemistica e Telematica, Università degli Studi di Genova

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
47 Channel Opening by Anesthetics and GABA Induces Similar Changes in the GABAA Receptor M2 Segment
 

Summary:  Channel Opening by Anesthetics and GABA Induces Similar Changes in the GABAA Receptor M2 Segment... submaximal GABA- induced currents. Higher concentrations directly activate the receptors. Functional effects... activate receptors in GABA's absence. At still higher ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
48 Cellular/Molecular Unnatural Amino Acid Mutagenesis of the GABAA Receptor
 

Summary:  receptors. Peak GABA-induced currents were recorded at 22 25°C from individual oocytes using the Opus... statistical significance using the same PRISM software. Modeling the GABAA receptor and docking of GABA... , and 2205) or tRNA-Phe ( 165) molecules, produced functional receptors that ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
49 Activation and block of recombinant GABAA receptors by pentobarbitone: a single-channel study
 

Summary:  ; single channel Abbreviation: PB, pentobarbitone sodium salt Introduction The GABAA receptor channel (GABA... on GABA receptors have shown that currents evoked by PB are indistinguishable in conductance from those... evoked by GABA, suggesting similarities in the open channel structure ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
50 TOWARDDEVELOPMENTOFBIOACTIVE,NEUROTRANSMITTER-IMMOBILIZED SURFACES FORINTERACTION WITH POST-SYNAPTIC MEMBRANERECEPTORS
 

Summary:  to this work. Abstract- Here we report progress toward the development of bioactive surfaces based on GABA... on antibodies, enzymes, and receptors, to our knowledge, this is the first report of a prototype... of avidin and subsequent attachmento fa derivatized form of GABA via a biotin-avidin aiffinity bond. Surface

  

Source: Vu, Tania - Division of Biomedical Engineering, Oregon Health and Science University

 

Collection: Engineering ; Biotechnology

 
51 Brain Research 959 (2003) 295303 www.elsevier.com/locate/brainres
 

Summary:  . Iontophoresis of the antagonists and agonists of GABA receptors were employed to separately investigate... the contribution of GABA and GABA receptors to pattern adaptation of LGNd cells. When GABA receptorsA B A were... , a selective ...

  

Source: Zhou, Yi-Feng - School of Life Sciences, University of Science and Technology of China

 

Collection: Biology and Medicine

 
52 Cellular/Molecular State-Dependent Cross-Linking of the M2 and M3 Segments
 

Summary:  receptors In electrophysiological experiments, we recorded GABA- induced currents (IGABA) from oocytes... expressing GABA 1 1 2 receptors. Where applicable, the 1 wt subunit was substituted by mutant 1 subunits... 1 2 receptors, DTT potentiated GABA-induced currents ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
53 -Aminobutyric Acid Increases the Water Accessibility of M3 Membrane-Spanning Segment Residues in -Aminobutyric Acid Type A Receptors
 

Summary:  of GABA to the GABAA receptors stimulates the opening and subsequent desensitization of an anion... 1). We measured the EC50 for GABA activation of wild-type receptor and each of the cysteine... substitution mutants. For wild-type receptor the GABA EC50 was 2.1 1.3 M ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
54 Altering cannabinoid signaling during development disrupts neuronal activity
 

Summary:  . Indeed, activation or block- ade of presynaptic GABAB receptors, which is another system controlling GABA... to activate G protein-coupled CB1 receptors and de- crease the release probability of GABA or glutamate (4, 5... CB1 receptors, and decrease GABA release. ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
55 Synaptic Signaling Between Neurons SHIH-CHUN LIN AND DWIGHT E. BERGLES*
 

Summary:  ionotropic receptors for glutamate and -aminobutyric acid (GABA) (Verkhratsky and Stein- hauser, 2000... ;elicit A-type (IA) and delayed-rectifier type (IK) K cur- rents in NG2 cells, unlike the voltage... suggests that the GABA reaching these receptors is released from local circuit ...

  

Source: Bergles, Dwight - Department of Neuroscience, Johns Hopkins University; Lin, Anna L. - Department of Physics, Duke University

 

Collection: Biology and Medicine ; Physics

 
56 Steroids can have rapid effects on mood and behaviour of animals, and on the function of neurons. A number of
 

Summary:  ). These studies have shown that PS can block receptors when applied before GABA (Zaman et al. 1992), indicating... that receptors with bound GABA can also be blocked. Experiments using steroids that potentiate GABAA receptor... receptor. METHODS Rat ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
57 Different Residues in the GABAA Receptor 1T60-1K70 Region Mediate GABA and SR-95531 Actions*
 

Summary:  Different Residues in the GABAA Receptor 1T60- 1K70 Region Mediate GABA and SR-95531 Actions... A (GABAA), receptor and explored the conformational changes that occur within the GABA-binding site during... ) receptors expressed in Xenopus oocytes. Data points were normal- ized to Imax for ...

  

Source: Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
58 GABA Transporter-1 (GAT1)-Deficient Mice: Differential Tonic Activation of GABAA Versus GABAB Receptors in the Hippocampus
 

Summary:  , where it lowers the ambient [GABA]o near GABAA receptors and GABAB auto- and heteroreceptors (Mitchell... each of 4 experiments with all 3 genotypes). 2691GABA RECEPTOR ACTIVATION IN GAT1 KO MICE J... per se on the GABA receptor currents. All chemicals were ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
59 Interneuron Diversity series Diversity of inhibitory
 

Summary:  and by the magnitude and duration of the GABA transient. Moreover, the kinetics of GABAA receptor openings might even... ]. Some GABAA receptors can be found at or beyond the perimeter of GABA synapses [7,8]. Comparable... GABA release should not be considered to activate only synaptic ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
60 1226 ajp.psychiatryonline.org Am J Psychiatry 167:10, October 2010 (Am J Psychiatry 2010; 167:12261231)
 

Summary:  (MRS), and reduced prefrontal GABA type A (GABAA)- benzodiazepine receptor complex have consistently... and rodents, GABA re- ceptor antagonists generally exert anxiogenic effects, while GABA receptor agonists (e... , Nutt DJ: Decreased brain GABA(A)-benzodiazepine ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine


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61 nature neuroscience volume 2 no 12 december 1999 1041 Olfaction is something of a luxury for
 

Summary:  GABA and inhibits (­) the mitral cell. The A-type potassium conductance (IA) in the granule cell... joined forces to provide a completely new interpretation for the field NMDA­GABA receptor link... , they showed that granule cell dendrites possess a high density of A-type potassium ...

  

Source: Segev, Idan - Department of Neurobiology, Hebrew University of Jerusalem

 

Collection: Biology and Medicine

 
62 Original Paper Brain Behav Evol 2005;65:127142
 

Summary:  [Schmidt, 1984]. GABA could thus influence calling behavior in the bullfrog. In birds, the GABAA receptor... ]. The inhibitory influence of GABA within the anuran visual system is evi- dence for the GABAA receptor... -NMDA, and GABA receptors to postsynaptic responses ...

  

Source: Boyd, Sunny K. - Department of Biological Sciences, University of Notre Dame

 

Collection: Biology and Medicine

 
63 Towards a Dynamic Neuropharmacology: Integrating Network and Receptor Levels
 

Summary:  regulators acting on the barbiturate or benzodi- azepine sites of GABA receptors, these drugs have both... of the GABAA receptor. (Both barbiturates and benzodiazepines shift the GABA concentration-response curve... not contain subunits (see later). One more difference is that at high concentration ...

  

Source: Tóth, János - Institute of Mathematics, Budapest University of Technology and Economics

 

Collection: Mathematics

 
64 Brain Research 868 (2000) 202214 www.elsevier.com/locate/bres
 

Summary:  of CA1 pyramidal neuron GABA receptorA channels and the appearance of a GABA -receptor mediated... -clamp techniques were used to record evoked, GABA receptor-mediated IPSCs carried by HCO ­ClA 3 2 or Cl alone... mM DNQX. The3 3 micropipette contained 130 mM CsCl and ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
65 Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal Neurons
 

Summary:  by different GABAA receptor subtypes with different affinities for GABA. Key words: GABA affinity; tonic... - tizing receptor with high affinity for GABA located extrasynap- tically would be ideal for mediating... affinity for GABA than -subunit-containing ...

  

Source: Journal Neuroscience -- Rapid Communications

 

Collection: Biology and Medicine

 
66 A conserved salt bridge critical for GABAA receptor function and loop C dynamics
 

Summary:  evidence that this salt bridge is critical for GABA activation of the receptor. Moreover, using disulfide... responses Receptor (EC50, M) GABA nH mut/WT N G kcal/mol (EC50, M) PB nH mut/WT N G kcal/mol WT 13.3 1.5 1... GABA induced current by 44.4 4.7% (n 7) for the double cysteine ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
67 Cellular/Molecular GABA Affinity Shapes IPSCs in Thalamic Nuclei
 

Summary:  the activation phase, all current responses decayed while in equilibrium with GABA (i.e., the receptors... by changes in receptor gating or desensitization kinetics but can be attributed to slow GABA unbinding. Entry... of GABA at varying inter- vals. If an initial brief ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
68 GABAA Receptor M2M3 Loop Secondary Structure and Changes in Accessibility during Channel Gating*
 

Summary:  chimeras between the GABA receptor extracellular domain and the glycine receptor mem- brane-spanning domain... loop alter agonist efficacy in GABA, ACh, and glycine receptors (20­24). Naturally occurring mutations... 278C 1 2 receptors. MTSET application in the ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
69 JournalofPhysiology The GABAA receptor constitutes a major inhibitory force
 

Summary:  that ethanol influences channel closing with no effect on the affinity of the receptor for GABA or the channel... of the receptor for GABA, an increased channel opening rate constant, an increase in the number of active... for GABA, or how fast the receptor channel ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
70 GABA Receptors Containing Rdl Subunits Mediate Fast Inhibitory Synaptic Transmission in Drosophila Neurons
 

Summary:  GABA Receptors Containing Rdl Subunits Mediate Fast Inhibitory Synaptic Transmission in Drosophila... , the functional properties of synaptic GABA receptors in Drosophila have not been described. Here, we report... to bath application of picrotoxin demonstrates that these GABA ...

  

Source: Lee, Daewoo - Department of Biological Sciences, Ohio University

 

Collection: Biology and Medicine

 
71 Frontiers in Cellular Neuroscience www.frontiersin.org July 2010 | Volume 4 | Article 17 | 1 CELLULAR NEUROSCIENCE
 

Summary:  of GABA(A) receptors are long (mean, 65 ms) and variable (within a time window of 10­200 ms). During patch... GDPsamplitude,desynchronizedneuronalfiringduringGDPsandsloweddown GDPs propagation. Partial blockade of GABA(A) receptors with bicuculline increased neuronal... mM frozen stock solution.Driving force ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
72 -Aminobutyric Acid (GABA) and Pentobarbital Induce Different Conformational Rearrangements in the GABAA
 

Summary:  . For 1K221C 2 receptors, pentobarbital decreased the rate of cysteine modification whereas GABA had... no effect. For 1 2K215C receptors, pentobarbital had no effect whereas GABA increased the modification rate... region of the 1 (K219C, K221C) and 2 (K213C, K215C) subunits had no effects on ...

  

Source: Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
73 Interneurons set the tune of developing networks
 

Summary:  on the developmental aspects of the crosstalk between these two building blocks. GABA receptors and synapses... , the developmental profile of markers of GABA receptors and GABA synapses takes place very early and provides... selective glutamate and GABA ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
74 Cellular/Molecular Neuroscience Senior Editor: Dr. Laurence O. Trussell
 

Summary:  receptor kinetics, which in turn shape reponses to both ambient and synaptic GABA exposure. Here we... (GABA) exerts rapid inhibitory effects by binding to GABAA receptors. Enhancement of GABAA receptor... a higher affinity for GABA and slower desensitization than ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
75 ABBREVIATiONS: GABAR, y-aminobutyric acid type A receptor; GABA, y-aminobutyric acid; HEPES, 4-(2-hydroxyethyl)-1 -piperazineethane-sulfonic acid; PIPES, piperazine-N,N'-bis(2-ethanesulfonic acid); DZP, diazepam; ZOL, zolpidem; I-V. current-voltage, Vh, m
 

Summary:  ABBREVIATiONS: GABAR, y-aminobutyric acid type A receptor; GABA, y-aminobutyric acid; HEPES, 4... (GABA) type A receptor (GABAR) were transfected into L929 cells together with cDNAs encoding ei- ther... for func- tional receptor assembly in these cells. The GABA ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
76 GABAA Receptor 2 Tyr97 Line the GABA-binding Site
 

Summary:  GABAA Receptor 2 Tyr97 and Leu99 Line the GABA-binding Site INSIGHTS INTO MECHANISMS OF AGONIST... -mediated chloride current; GABAA, GABA type A; GABAAR, GABA type A receptor; MTS, N-biotinylamin- oethyl... --Oocytes expressing either wild-type or mutant receptors were ...

  

Source: Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
77 Cellular/Molecular The Transporters GlyT2 and VIAAT Cooperate to Determine
 

Summary:  mediated by the activa- tion of glycine or GABA receptors were fitted using the Hill equation: I Imax 1 EC... /GlyR EXP1 cells (Fig. 4E). Although EXP-1 is insensitive to blockers of vertebrate GABA receptors... to the ac- tivation of EXP1 receptors by GABA release ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
78 Brain Research Bulletin 71 (2006) 219223 OFF response of bullfrog cones is shaped by terminal
 

Summary:  ionotropic GABA receptors Jian Liua,b, Xiong-Li Yanga, a Institute of Neurobiology, Institutes of Brain... Available online 2 October 2006 Abstract We recently reported an ionotropic GABA receptor expressed... the patch clamp technique in current clamp mode, we show that activation of this ...

  

Source: Liu, Jian - Harvard University

 

Collection: Biology and Medicine

 
79 Supplemental Data Epileptogenic Actions of GABA and Fast Oscillations in the
 

Summary:  Supplemental Data Epileptogenic Actions of GABA and Fast Oscillations in the Developing Hippocampus... Receptors Is Required for the Generation of FOs and the Formation of a Secondary Focus (A) Kainate... was repeatedly applied to one hippocampus (ipsi) and the NMDA receptor antagonist APV (100 µm) was continuously

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
80 Glycine and GABAA Receptor Subunits on Renshaw Cells: Relationship With
 

Summary:  markers. We postulate that GABA and glycine corelease, and the presence of 3-containing GABAA receptors... that corelease GABA and glycine and express postsynaptic GABAA and glycine receptors induce postsynaptic currents... presynaptically might not always activate postsynaptic ...

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collection: Biology and Medicine


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81 news and views nature neuroscience volume 2 no 3 march 1999 201
 

Summary:  properties of the particular sort of GABA receptor- channel that is a homomeric assem- bly of 1 subunits... bindings of GABA mole- cules to the receptor are followed by iso- merisation to the open state (though... news and views nature neuroscience · volume 2 no 3 · march 1999 201 ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
82 Cellular/Molecular Charged Residues in the 1 and 2 Pre-M1 Regions Involved
 

Summary:  : GABA; GABAA receptor; pre-M1 region; substituted cysteine accessibility method; electrostatic... ) and GABA-bound receptor states (open/desensitized) to determine whether structural movements occur... - cytes expressing 1 2R216C receptors had no functional re- sponse to ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Zhang, Su-Chun - Neuroscience Training Program & Waisman Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
83 Special article Basic developmental rules
 

Summary:  be generated when GABA synapses are operative in the developing brain: GABA receptor antagonists are ictogenic... figure 4-6). These cur- rents are mediated by the activation of GABA- and glutamate NMDA-type receptors... receptor antagonist generates a tonic current ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
84 J.A. Reggia, E. Ruppin and D. Glanzman (Eds.) Progress in Bmin Research, Vol 121
 

Summary:  the appli- cation of antagonists of GABA, receptors and second, that the genesis of these oscillations... (TC) cells. The critical role for thalamic GABA, receptors on TC cells was established... , there is a diminished frequency of seizures following reinforcement of GABA, ...

  

Source: Destexhe, Alain - Unité de Neurosciences Intégratives et Computationnelles, CNRS

 

Collection: Biology and Medicine

 
85 Identification of Transduction Elements for Benzodiazepine Modulation of the GABAA Receptor: Three Residues Are Required
 

Summary:  and a conformational transition step in which the affinity of the receptor for GABA changes. Previously, using 2 / 1... for other members of the ligand- gated ion channel superfamily. Key words: GABA; GABAA receptor... with the vehicle. Maximal current ( 3­8 A) for all receptors was ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
86 ( )A.A. Roberts, C.K. KelloggrDeelopmental Brain Research 119 2000 2132 GABA receptor subtypes that differ in subunit combina-A
 

Summary:  #12;( )A.A. Roberts, C.K. KelloggrDeelopmental Brain Research 119 2000 21­32 GABA receptor subtypes... of GABA receptor activity increases A in multiple brain areas over postnatal development #12;( )A... DeÕelopmental Brain Research 119 2000 21­32 27 Fig. 3. Postnatal changes in relative levels of ...

  

Source: Kellogg, Carol K. - Department of Brain and Cognitive Sciences, University of Rochester

 

Collection: Biology and Medicine

 
87 3 -Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABAA Receptor Antagonists
 

Summary:  concentrations of GABA and/or directly gate GABAA receptor channels in the absence of GABA (Majewska, 1992... in Xeno- pus oocytes expressing recombinant GABAA receptors contain- ing 1, 2, and 2L subunits and on GABA... a combination of 1 2 2L GABAA receptor ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
88 Neuropharmacology 44 (2003) 10031012 www.elsevier.com/locate/neuropharm
 

Summary:  deactivation. In addition, abg receptors had an increased GABA EC50, reduced sensitivity to block by Zn2... to application of 1 mM GABA as a function of holding potential. Curves obtained for abg (1:1:10) receptors were... abg receptors (t = 24.8 ± 3.4 s, n = 9, p 0.001; data not ...

  

Source: Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
89 Biomaterials 26 (2005) 18951903 Activation of membrane receptors by a neurotransmitter conjugate
 

Summary:  -synaptic receptor proteins. Muscimol (5-aminomethyl-3-hydroxyisoxazole), an analog of GABA (g-aminobutryic acid... of ``muscimol-biotin'' on cloned GABA receptors expressed in Xenopus oocytes. This compound, which... . Keywords: Neurotransmitter; GABA receptor; ...

  

Source: Vu, Tania - Division of Biomedical Engineering, Oregon Health and Science University

 

Collection: Engineering ; Biotechnology

 
90 nature neuroscience volume 4 no 5 may 2001 477 Ligand-gated ion channels are allosteric proteins that couple
 

Summary:  and activated receptors. With or without GABA, disulfide bonds formed at 1N275C/1E270C (20´) and 1S272C/1H267C... :phen applications. To maximally activate the receptors during application with DTT or Cu:phen, a GABA concentration... to reduce the receptors. Brief (10 s) test pulses of ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University; Jackson, Meyer B. - Neuroscience Training Program & Department of Physiology, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
91 ORIGINAL PAPER Guillaume Stephane Barbara Christina Zube
 

Summary:  data indicate the existence of an ionotropic GABA receptor which is permeable to chloride ions... within the nervous system of insects and ionotropic GABA receptors mediate fast inhibitory synaptic... transmission. The insect ionotropic GABA receptor is a chloride ...

  

Source: Menzel, Randolf - Institut für Biologie - Institut für Biologie, Freie Universität Berlin

 

Collection: Biology and Medicine

 
92 Proc. Natl. Acad. Sci. USA Vol. 92, pp. 7749-7753, August 1995
 

Summary:  of a and P subunits is sufficient to form GABA- gated ion channels, as shown in recombinant receptors... for electrophysi- ological receptor assays. Compared to wild-type neurons, the GABA dose-response curve in 720... the y2 subunit contributes to (i) the sensitivity of the receptor to ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
93 Suppression of Neuronal Hyperexcitability and Associated Delayed Neuronal Death by Adenoviral Expression of GABAC Receptors
 

Summary:  directly the sensitivity of postsynaptic neurons to GABA. The GABAC receptor, normally found only... ). Enhancement of the GABA effect at the receptor is a reasonable strategy for increasing inhibition... (Hevers and Luddens, 1998). An alternative to receptor modulation is chang- ing the ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
94 Distinct Structural Changes in the GABAA Receptor Elicited by Pentobarbital and GABA
 

Summary:  Distinct Structural Changes in the GABAA Receptor Elicited by Pentobarbital and GABA Yukiko Muroi... GABA binds, the GABAA receptor has structurally distinct binding sites for many of its other ligands... formed by b-subunit homomeric receptors, but GABA cannot ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
95 J Physiol 568.3 (2005) pp 951966 951 Epileptiform activity triggers long-term plasticity of GABAB
 

Summary:  . 2003) and modifications of ionotropic -aminobutyric acid (GABA)-receptor mediated synaptic... of GABAB receptors (GABABRs) to elevated quantities of endogenous GABA could impair GABABR... a pattern of GABA release similar to that induced by high K+ (see Methods) while preserving GABAB ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
96 Pentobarbital affects GABAA receptor-mediated responses in several ways. At low micromolar concentrations it potentiates
 

Summary:  concentrations it potentiates GABA-evoked responses, at high micromolar concentrations it opens GABAA receptors... anaesthetics do not exert the same effects on all the GABA-gated receptor Cl¦ ion channels (Thomson et al. 1996... in the binding of GABA to GABAA ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
97 Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian-Specific
 

Summary:  Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian... relationships of GABA receptor subunits across the chordates and detail their mode of evolution among mammals... . The presence of GABA receptor subunits from each of the ...

  

Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
98 Cellular/Molecular GABA-Induced Intersubunit Conformational Movement in
 

Summary:  Cellular/Molecular GABA-Induced Intersubunit Conformational Movement in the GABAA Receptor 1M1- 2M3... C (Table 1). A 90 s application of 5 mM DTT to 1Y231C 2 2 receptors did not affect subsequent GABA... receptors irreversibly modified the subsequent GABA-induced ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
99 BIOLOGY OF REPRODUCTION 52, 373-381 (1995) Evidence That a GABAA-Like Receptor Is Involved in Progesterone-lnduced
 

Summary:  exocytosis involves the activation of a y-aminobutyric acid (GABA) receptor, and whether activation... for 120 min did. Stimulation of capacitated spermatozoa with GABA or muscimol, two GABAA receptor agonists... or GABA. Picrotoxin, another GABAA receptor ...

  

Source: Museo Nacional de Ciencias Naturales - Madrid, Reproductive Ecology and Biology Group

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
100 SAMPLE EXAM QUESTIONS Multiple Choice
 

Summary:  the cortex and that these DA terminals possess Glu and GABA presynaptic receptors, which of the following... receptor docking site (b) the peptide might influence the ability of DA to open or close ion gates (c) DA... subtypes of the NT's receptor on the same target neuron (d) different subtypes of a NT's ...

  

Source: Bruno, John P. - Department of Psychology, Ohio State University

 

Collection: Biology and Medicine


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