| Sample search results for: aav genetic vaccines |
| 1 | JOURNAL OF VIROLOGY, Apr. 2004, p. 33613371 Vol. 78, No. 7 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.7.33613371.2004 | ||
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Summary: . This explains the difficulty of developing effective vaccines for ADV (8). Con- cerning AAV vectors... and genetically manipulate, major efforts toward the production and purifica- tion of the AAVs improved our... . Our AAV2-based model of AAV5 provides a bench- mark ... |
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Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 2 | Expert Review Designer Gene Delivery Vectors: Molecular Engineering and Evolution | ||
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Summary: (38). Since the biology and genetics of the AAV2 genome have been broadly studied, pseudotyping a AAV2... Engineering The majority of AAV targeting studies have involved direct genetic insertion of targeting ligands... . Furthermore, the genetically modified virus ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 3 | original article 594 www.moleculartherapy.org vol. 18 no. 3, 594600 mar. 2010 | ||
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Summary: Society of Gene & Cell Therapy Selecting the most efficient recombinant adeno- associated virus (rAAV... and immune response between humans and ani- mal models. Chimpanzees--the closest surviving genetic relative... promis- ing rAAV serotypes following lung coinfection. Analysis of differential luciferase activity |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 4 | JOURNAL OF VIROLOGY, June 2008, p. 58875911 Vol. 82, No. 12 0022-538X/08/$08.00 0 doi:10.1128/JVI.00254-08 | ||
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Summary: and Mark A. Kay1 * Departments of Pediatrics and Genetics, 300 Pasteur Drive,1 and Department... February 2008/Accepted 2 April 2008 Adeno-associated virus (AAV) serotypes differ broadly in transduction... , however, their use in patients is restricted by prevalent anti-AAV immunity or by their inadequate |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 5 | Zerit (Bristol-Myers) Emtriva (HIV/Gilead) | ||
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Summary: -P101 (Neurologix) AAV hAADC2G ) The Yale Pharmaceutical Pipeline Preclinical Phase I Phase II Phase III... NDA/BLA Market AAV-hAADC2Genzyme) FESTINAVIR® (Oncolys/Bristol Myers Squibb) Radezolid (RX-1741) (Rib... -X) Vax125(VaxInnate) VSV Vaccine (Profectus) M2e Influenza vaccine (VaxInnate) NHP 229 ... |
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Source: Wang, Xiao-Jing - Kavli Institute for Neuroscience & Department of Neurobiology, Yale University |
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Collection: Biology and Medicine |
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| 6 | Directed evolution of adeno-associated virus yields enhanced gene delivery vectors | ||
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Summary: Library generation and vector packaging. An AAV2 cap ORF genetic library was generated by error-prone PCR... treated with an AAV vector. Nat. Genet. 24, 257261 (2000). 7. Manno, C.S. et al. AAV-mediated factor IX... (AAV) 2 variants with enhanced properties. ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 7 | JOURNAL OF VIROLOGY, Aug. 2002, p. 76517660 Vol. 76, No. 15 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.15.76517660.2002 | ||
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Summary: Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the treatment of retinal... degenerative diseases. In prior work, subretinal injections of AAV2, AAV5, and AAV2 pseudotyped with AAV5... capsids (AAV2/5) showed variable retinal pigmented ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 8 | 64 NATURE MEDICINE VOLUME 5 NUMBER 1 JANUARY 1999 Hemophilia is an X-linked recessive bleeding disorder that | ||
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Summary: gene transfer of recombinant AAV vectors. Nature Genet. 16, 270-275 (1997). 24. Miao, C.H. et al... . The kinetics of rAAV integration in the liver. Nature Genet. 19, 1315 (1998). 25. Nakai, H. et al. Adeno... to have toxicity and immunogenicity associated with the therapy. Recombinant adeno-associated ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 9 | Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders | ||
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Summary: genetic forms has been unsuccessful. rAAV-mediated ribozyme knockdown of parkin, an E3 ligase involved... Department of Molecular Genetics and Microbiology, 2 Powell Gene Therapy Center, and McKnight Brain Institute... @ufl.edu. Available online 18 January 2006 Recombinant adeno-associated virus (rAAV) is ... |
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Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 10 | Current Gene Therapy, 2003, 3, 281-304 281 1566-5232/03 $41.00+.00 2003 Bentham Science Publishers Ltd. | ||
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Summary: -associated Virus (AAV) as Novel Vectors for Human Gene Therapy D. Grimm and M.A. Kay* Stanford University, School... of Medicine, Departments of Pediatrics and Genetics, 300 Pasteur Drive, Stanford, California, 94305, USA... Abstract: Gene transfer vectors based on the human adeno-associated virus serotype 2 (AAV-2) have been |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 11 | A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2 | ||
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Summary: of Medicine, Stanford, California, USA; 2 Department of Genetics, Stanford University School of Medicine... . A particularly interesting candidate is AAV8, which can efficiently and rapidly transduce a wide range of tissues... in vivo. To further unravel the mechan- isms behind AAV8 transduction, we used yeast two- hybrid ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 12 | Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia* | ||
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Summary: .3, and AAV5 helper pBS-HSP-R2C5 were provided by Targeted Genetics Inc. (Seattle, WA). AAV1 helper plasmid p5... by Targeted Genetics Inc. The identical rAAV2 genome was encapsidated into different AAV serotype capsids... Unique Biologic Properties of Recombinant ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 13 | Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display | ||
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Summary: Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display... ,2,3,y 1 Department of Molecular Genetics and Microbiology, 2 Powell Gene Therapy Center, 4 Department... should be addressed at the Department of Molecular Genetics and Microbiology, College of Medicine, Box |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 14 | JOURNAL OF VIROLOGY, Mar. 2002, p. 20432053 Vol. 76, No. 5 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.5.20432053.2002 | ||
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Summary: 2001 In the presence of complementing adeno-associated virus type 2 (AAV-2) Rep proteins, AAV-2 genomes... can be pseudotyped with the AAV-5 capsid to assemble infectious virions. Using this pseudotyping... strategy, the involvement of the ubiquitin-proteasome system in AAV-5 and AAV-2 ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 15 | original article The American Society of Gene & Cell Therapy Molecular Therapy 1 | ||
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Summary: the transduction efficiency of different adeno-associated virus (AAV) capsid serotypes encod- ing for green... fluorescent protein (GFP) flanked by AAV2 inverted terminal repeats in the nonhuman primate basal ganglia... ). Six intact young adult cynomolgus monkeys received a single 10µl injection of AAV2/1-GFP, ... |
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Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 16 | SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret, | ||
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Summary: SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret, pig and human airway... and Other Genetic Diseases, College of Medicine, The University of Iowa, Iowa City, IA, USA Differences... - associated virus (rAAV)-mediated gene therapies to the lung for cystic fibrosis (CF). As new ferret and pig |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 17 | Intracellular trafficking of adeno-associated viral and JF Engelhardt1,2,3 | ||
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Summary: are accelerating42,85 and have complemented genetic analyses of the AAV2 capsid that has revealed an enormous... Adeno-associated virus (AAV) has attracted considerable interest as a gene therapy vector over the past... decade. In all, 85% of the current 2052 PubMed references on AAV (as of December 2004) ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 18 | JOURNAL OF VIROLOGY, Oct. 2006, p. 98319836 Vol. 80, No. 19 0022-538X/06/$08.00 0 doi:10.1128/JVI.00878-06 | ||
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Summary: Grimm, Kusum Pandey, Stephen R. Yant, Hui Xu, and Mark A. Kay* Departments of Pediatrics and Genetics... Adeno-associated virus serotype 8 (AAV8) is currently emerging as a powerful gene transfer vector, owing... to be in part due to its ability to uncoat more readily than other AAV serotypes such as AAV2, ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 19 | Helper Virus-Free, Optically Controllable, and Two-Plasmid-Based Production of Adeno-associated | ||
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Summary: Department of Pediatrics and Department of Genetics, Stanford University School of Medicine, 300 Pasteur... strategy for producing high-titer adeno-associated virus (AAV) vectors derived from six different AAV... serotypes (AAV-1 to AAV-6). The method, referred to as "HOT," is helper ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 20 | Characterization of the Relationship of AAV Capsid Domain Swapping to Liver | ||
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Summary: Characterization of the Relationship of AAV Capsid Domain Swapping to Liver Transduction Efficiency... , Stanford, California, USA; 2 Department of Genetics, Stanford University, Stanford, California, USA... Recombinant adeno-associated virus (AAV) vectors show promise for use in gene therapy. For liver-targeted gene |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 21 | JOURNAL OF VIROLOGY, Apr. 2005, p. 50475058 Vol. 79, No. 8 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.8.50475058.2005 | ||
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Summary: of Molecular Genetics and Microbiology,4 and Powell Gene Therapy Center,5 College of Medicine, University... , Bethesda, Maryland3 Received 14 July 2004/Accepted 17 November 2004 Adeno-associated virus (AAV... of AAV are in development for use in human gene therapy applications due to their ability to transduce |
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Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 22 | HUMAN GENE THERAPY 15:405413 (April 2004) Mary Ann Liebert, Inc. | ||
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Summary: transfer of recombinant AAV vectors. Nat. Genet. 16, 270276. STILWELL, J.L., and SAMULSKI, R.J. (2003... -associated virus (AAV) are two of the most efficient at transducing nondividing cells. We have constructed... recombinant adenovirus (AdVLacZ), adeno-associated virus serotype 2 (AAV2LacZ), and ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 23 | JOURNAL OF VIROLOGY, Mar. 2004, p. 31103122 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.31103122.2004 | ||
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Summary: and Genetics, Stanford University School of Medicine, Stanford, California 94305 Received 26 August 2003... (AAV2) vectors is ineffi- cient; less than 10% of hepatocytes are permissive for stable transduction... , and transgene expression is characterized by a lag phase of up to 6 weeks. AAV2-based vector genomes packaged |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 24 | original article The American Society of Gene Therapy Molecular Therapy vol. 16 no. 10, 17031709 oct. 2008 1703 | ||
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Summary: of inherited and acquired genetic disorders successfully.13 AAV is a nonpathogenic member of the Parvoviridae... 1709 oct. 2008 1703 Adeno-associated virus (AAV) vectors are extremely effective gene-delivery vehicles... , and infection of off-target cells. Recently, we have implemented directed evolution of ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 25 | original article 2088 www.moleculartherapy.org vol. 17 no. 12, 20882095 dec. 2009 | ||
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Summary: (AAV) vectors, leads to predomi- nant transduction of neurons and epithelia within the central nervous... , and as causal contributors in genetic disorders such as Alzheimer's and amyotrophic lateral sclerosis, efforts... creation of AAV vec- tors with valuable new gene delivery properties. We have engineered novel ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 26 | JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0 | ||
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Summary: of Pediatrics and Genetics, Stanford University School of Medicine, Stanford, California 94305 Received 16 March... 2000/Accepted 28 July 2000 Recombinant adeno-associated virus (rAAV) vectors stably transduce... hepatocytes in experimental animals. Following portal-vein administration of rAAV vectors in vivo, single |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 27 | original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285 | ||
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Summary: of genetic defects in stem/progenitor cells. Indeed, proof of principle for gene correction with rAAV has... . 2009 285 Although recombinant adeno-associated virus (rAAV) has been widely used in lung gene therapy... approaches, it remains unclear to what extent commonly used AAV serotypes transduce adult ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 28 | Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer Superior | ||
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Summary: Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer... Superior to That of AAV8 Katsuya Inagaki,1 Sally Fuess,2 Theresa A. Storm,2 Gregory A. Gibson,3 Charles F... . Mctiernan,3 Mark A. Kay,2 and Hiroyuki Nakai1,* 1 Department of Molecular Genetics & Biochemistry and 3 |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 29 | JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0 | ||
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Summary: AND MARK A. KAY2 * Division of Medical Genetics, University of Washington, Seattle, Washington 98195... ,1 and Departments of Pediatrics and Genetics, Stanford University, Stanford, California 94305-52082 Received 3 June... . As a specific application of this finding, we generated adenovirusadeno-associated virus (AAV) hybrid ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 30 | Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host | ||
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Summary: .IX. Recombinant AAV vectors have provided long-term cures of genetic disease in a number of large-animal models1... . Genet. 24, 257261 (2000). 7. Manno, C.S. et al. AAV-mediated factor IX gene transfer to skeletal muscle... Successful transduction of liver in hemophilia by AAV-Factor IX ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 31 | GENE THERAPY Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors | ||
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Summary: treated with an AAV vec- tor. Nat Genet. 2000;24:257-261. 9. High KA. Adeno-associated virus-mediated gene... Colosi, and Mark A. Kay We report the generation and use of pseudotyped adeno-associated viral (AAV... ) vectors for the liver-specific expres- sion of human blood coagulation factor IX (hFIX). Therefore, an ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 32 | JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.16.76627671.2001 | ||
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Summary: in haemophilia B patients treated with an AAV vector. Nat. Genet. 24:257261. 18. Li, J., D. Dressman, Y. P. Tsao... of Cystic Fibrosis and Other Genetic Diseases,2 College of Medicine, The University of Iowa, Iowa City, Iowa... 52242 Received 22 March 2001/Accepted 11 May 2001 Adeno-associated virus ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 33 | Investor and Media Contact: Stacie D. Byars | ||
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Summary: OF RECOMBINANT AAV VECTORS Seattle, WA October 18, 2006 Targeted Genetics Corporation (Nasdaq: TGEN) today... that is not associated with any disease in humans. AAV vectors can #12;efficiently deliver genetic information... ® Investor and Media Contact: Stacie D. Byars Director, Communications Targeted ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 34 | Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd. | ||
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Summary: linked to the genetic defect. Interestingly, UV irradiation also increases the abundance of rAAV circular... Publishers Ltd. Rate Limiting Steps of AAV Transduction and Implications for Human Gene Therapy S. Sanlioglu1... of Medical Biology and Genetics, Akdeniz University, College of Medicine, Antalya, ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 35 | JOURNAL OF VIROLOGY, Oct. 2007, p. 1130411321 Vol. 81, No. 20 0022-538X/07/$08.00 0 doi:10.1128/JVI.01225-07 | ||
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Summary: Theresa A. Storm,2 Mark A. Kay,2 and Hiroyuki Nakai1 * Department of Molecular Genetics & Biochemistry... and Genetics, Stanford University School of Medicine, Stanford, California 943052 Received 4 June 2007/Accepted... of adeno-associ- ated virus (AAV) are processed by DNA repair machinery; however, how and what cellular |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 36 | JOURNAL OF VIROLOGY, July 2003, p. 73617366 Vol. 77, No. 13 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.13.73617366.2003 | ||
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Summary: -Strand Genome Conversion of Adeno-Associated Virus Type 2 (AAV-2) and AAV-5 Is Not Rate Limiting following... Center for Cystic Fibrosis and Other Genetic Diseases, University of Iowa, Iowa City, Iowa 52242... ,1 and Center for Genetic Lung Disease, National Jewish Medical and Research Center, University of ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 37 | JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0 | ||
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Summary: , Louisiana2 Received 7 July 1998/Accepted 1 October 1998 A central feature of the adeno-associated virus (AAV... , the molecular processes associated with episomal long-term persis- tence of AAV genomes are only poorly... understood. To investigate these mechanisms, we have utilized a re- combinant AAV (rAAV) ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 38 | The idea of gene-based therapeutics has been around for some time, but it only received serious attention | ||
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Summary: that is missing owing to genetic mutation. The least common of the techniques, gene correction/ alteration, has... of Pediatrics and Genetics, Associate Pediatric Chair for Basic Research, Stanford University, 269 Campus Drive... used in therapeutic trials have led to substantial clinical successes in patients with serious ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 39 | HUMAN GENE THERAPY 10:591 602 (March 1, 1999) Mary Ann Liebert, Inc. | ||
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Summary: ). The ki- netics of rAAV integration in the liver. Nature Genet. 19, 13±15. [Letter] MILLER, D.G., ADAM, M... have been demonstrated to enhance recombinant adeno-associated virus (rAAV) transduction. Such findings... are the foundation of developing new and innovative strategies to im- prove the efficiency of ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 40 | JOURNAL OF VIROLOGY, Oct. 2007, p. 1129011303 Vol. 81, No. 20 0022-538X/07/$08.00 0 doi:10.1128/JVI.00963-07 | ||
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Summary: * Department of Molecular Genetics & Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh... , Pennsylvania 152611 ; Program in Genetics and Genome Biology, Hospital for Sick Children Research Institute... -Frederick, Frederick, Maryland 217023 ; and Departments of Pediatrics and Genetics, Stanford University ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 41 | JOURNAL OF VIROLOGY, Jan. 2005, p. 214224 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.214224.2005 | ||
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Summary: . Storm,1 Shin-ichi Muramatsu,2 Yuko Nara,2 and Mark A. Kay1,3 Departments of Pediatrics1 and Genetics,3... adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target... tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 42 | HUMAN GENE THERAPY 18:871880 (October 2007) Mary Ann Liebert, Inc. | ||
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Summary: in the rat retina. We used two viral vectors, based on lentivirus and adeno-associated virus (AAV... ), to deliver shRNAs and silence bFGF in retinal pigment epithelial cells in vivo. The AAV experiments made use... , School of Medicine, Stanford University, Stanford, CA 94305. 4Department of Genetics, School of Medicine |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 43 | NATURE BIOTECHNOLOGY VOL 18 MAY 2000 http://biotech.nature.com 527 Recombinant adeno-associated virus (rAAV) vectors based on AAV | ||
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Summary: transfer of recombinant AAV vectors. Nat. Genet. 16, 270276 (1997). 6. Snyder, R.O. et al. Efficient... -associated virus (rAAV) vectors based on AAV type 2 can safely transduce various tissues and result in persistent... into the portal vasculature, rAAV vector genomes enter almost all ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 44 | [23] Adeno-Associated Virus Vectors for Short Hairpin RNA Expression | ||
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Summary: ). In addition, beyond using naturally occurring AAV variants, multiple groups have succeeded in genetically... gene knockdowns in vivo and to test new genetic disease models. The usefulness of the AAV/shRNA system... of gene transfer vectors based on adeno-associated virus (AAV) for ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 45 | MOLECULAR AND CELLULAR BIOLOGY, May 2003, p. 35583565 Vol. 23, No. 10 0270-7306/03/$08.00 0 DOI: 10.1128/MCB.23.10.35583565.2003 | ||
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Summary: treated with an AAV vector. Nat Genet. 24:257261. 17. Marshall, E. 2002. Gene therapy a suspect... of Technology, Pasadena, California 91125,1 and Laboratory of Genetics, Salk Institute for Biological Studies... used in mammalian somatic cell genetics or to cure genetic diseases. ... |
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Source: Baltimore, David - Division of Biology, California Institute of Technology |
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Collection: Biotechnology ; Biology and Medicine |
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| 46 | JOURNAL OF VIROLOGY, Mar. 2004, p. 28632874 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.28632874.2004 | ||
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Summary: and Other Genetic Diseases,2 University of Iowa College of Medicine, Iowa City, Iowa 52242, and Targeted... Genetics Corporation, Seattle, Washington 981013 Received 12 August 2003/Accepted 21 November 2003... - tion and transduction of recombinant adeno-associated virus type 2 (rAAV-2) and rAAV-5 serotypes |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 47 | Loss of ATM Function Enhances Recombinant Adeno-Associated Virus Transduction and Integration through Pathways Similar to UV Irradiation | ||
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Summary: :298]. Nat. Genet. 17, 453456. 77ATM DEFICIENCY ENHANCES rAAV TRANSDUCTION #12;Berns, K. I. (1990... ). The kinetics of rAAV integration in the liver [letter]. Nat. Genet. 19, 1315. Miller, S. C., Taylor, A... by a genetic defect in the ATM gene that results in altered cellular ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 48 | Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic | ||
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Summary: antibody that linked AAV particles to IIb3 integrins expressed on the surface of these cells. Genetic... and in an in vivo xenograft tumor model [21]. Therefore, AAVs have the potential to be genetically redirected... - permissive OvCa cell lines. Finally, an AAV vector with a ... |
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Source: Hemminki, Akseli - Department of Biosciences, University of Helsinki |
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Collection: Biology and Medicine |
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| 49 | JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0 | ||
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Summary: of recombinant AAV vectors. Nat. Genet. 16:270276. 18. Summerford, C., J. S. Bartlett, and R. J. Samulski. 1999... 1999 Adeno-associated virus (AAV) is inefficient at infecting differentiated airway epithelia because... of a lack of receptors at the apical surface. We hypothesized that incorporation of AAV ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 50 | Enhanced Preparation of Adeno-Associated Viral Vectors by Using High Hydrostatic Pressure to | ||
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Summary: -Schaal et al., 1999), making AAV5 is the most genetically distant of the primate AAV serotypes 16 (Lukashov... to other serotypes, we also characterized the stability of vectors based on the genetically distant AAV5... based on adeno-asso- ciated virus (AAV) have ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 51 | BioMed Central Page 1 of 12 | ||
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Summary: and which drive gene expression in single strand AAV vectors in gene therapy protocols were very highly... to design pDC-based vaccines in humans, and they are also useful in vitro to evaluate the immunogenicity... adeno-associated virus (rAAV) with a genome conventionally packaged as single- stranded molecules (ss |
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Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique |
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Collection: Physics |
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| 52 | Directed evolution of adeno-associated virus to an infectious respiratory virus | ||
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Summary: the human therapeutic potential of a customized AAV vector. CF is a complex and lethal genetic disease... by nature, could greatly enhance the respiratory infectivity of a virus. Adeno-associated viruses (AAV... for replication and gene expression. Wild-type AAV is a 4.7 kb single-stranded DNA virus that ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 53 | original article 2096 www.moleculartherapy.org vol. 17 no. 12, 20962102 dec. 2009 | ||
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Summary: (AAV) serotypes can infect various cells of the retina when administered subretinally, but the retinal... and survival of retinal neurons. Intravitreal administration could cir- cumvent this problem, but only AAV2 can... several AAV serotype capsids and fol- lowed their retinal distribution after intravitreal injection. ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 54 | Virus Research 104 (2004) 5159 Novel approaches to augment adeno-associated virus | ||
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Summary: Available online 27 April 2004 Abstract Recombinant adeno-associated virus (rAAV) receptor binding... -limiting steps in rAAV type-2 (rAAV-2) transduction. Several strategies have been developed to enhance rAAV-2... therapy vector. To this end, the current study has investigated novel methods for augmenting ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 55 | Replication-defective viruses as vaccines and vaccine vectors Tim Dudek a,b | ||
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Summary: -defective vaccine vectors have been produced with many other viruses, including adeno-associated virus (AAV... Lean, C.S., 1997. A genetically inactivated herpes simplex virus type 2 (HSV-2) vaccine provides effective... Replication-defective viruses as vaccines and ... |
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Source: Knipe, David M. - Department of Microbiology and Molecular Genetics, Harvard University |
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Collection: Biology and Medicine |
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| 56 | JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0 | ||
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Summary: concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat. Genet. 16... and Departments of Pediatrics and Genetics, Stanford University, Stanford,2 and Cell Genesys, Foster City,3... California Received 3 August 1999/Accepted 5 January 2000 Recombinant adeno-associated virus vectors ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 57 | 2003 NaturePublishing Group 346 | MAY 2003 | VOLUME 4 www.nature.com/reviews/genetics | ||
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Summary: negatively affecting internalization57 .The AAV capsid has been successfully genetically engineered but... © 2003 NaturePublishing Group 346 | MAY 2003 | VOLUME 4 www.nature.com/reviews/genetics R E V I E W... with the promise to cure almost any disease -- pro- vided that we understood its genetic or ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 58 | COLE DOCTORALE : DES GNOMES AUX ORGANISMES UNIVERSIT D'VRY VAL D'ESSONNE | ||
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Summary: la vaccine ; on parle de fonctions « helper ». Le premier sérotype AAV sauvage caractérisé fut l'AAV... enseigner la prod AAV aux jeunes effrontés. Merci également à Bérangère, Christine, Samia, Christel, Diana... l'aide en production d'AAV, Émilie, Christophe Georger, Simon ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 59 | JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0 | ||
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Summary: -associated virus (rAAV) vectors for gene therapy of inherited disorders have demon- strated considerable potential... for molecular medicine. Recent identification of the viral receptor and corecep- tors for AAV type 2 (AAV-2) has... with this vector. However, the mechanisms by which AAV-2 enters cells ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 60 | ORIGINAL ARTICLE Surface immobilization of hexa-histidine-tagged | ||
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Summary: may thereby reduce off-target side effects. We have genetically engineered an AAV variant capable... , Berkeley, CA, USA Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical... the potential of AAV in a variety of therapeutic applications by reducing spread outside a target ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 61 | Linear DNAs Concatemerize in Vivo and Result in Sustained Transgene Expression | ||
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Summary: , B., and Kay, M. A. (1998). The kinetics of rAAV integration in the liver. Nat. Genet. 19: 1315. 9... of Pediatrics and Department of Genetics, Stanford University School of Medicine, Stanford, California 94305... in transfected cells. No differences in transgene expression or DNA molecular structures were observed when ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 62 | JOURNAL OF VIROLOGY, Jan. 2006, p. 426439 Vol. 80, No. 1 0022-538X/06/$08.00 0 doi:10.1128/JVI.80.1.426439.2006 | ||
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Summary: of genetic heter- ogeneity, with sequence homologies as low as 58% (AAV-5 and the rest, Fig. 1a... genotypes in stably transduced hepatocytes. (a) Scheme of the AAV-2 hfIX vector DNA. Shown are the genetic... , Kusum Pandey, Hiroyuki Nakai, Theresa A. Storm, and Mark A. Kay* Departments of Pediatrics and ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 63 | Introduction Cystic fibrosis (CF) is the most common inherited dis- | ||
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Summary: - virus, and adeno-associated virus (AAV), have been used in strategies conceived for functional... . The develop- ment of AAV as a gene therapy vehicle for treating CF has several unique advantages based on its... viral biology. For example, wild-type AAV infections are known to occur in the respiratory epithelium |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 64 | HUMAN GENE THERAPY 18:367378 (April 2007) Mary Ann Liebert, Inc. | ||
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Summary: exchange. Genetic modification of AAV has allowed for the study and design of its gene delivery properties... in genetic engineer- ing permit the customized design of AAV vectors for improved gene delivery, often based... -associated virus (AAV) is a promising vehicle for gene therapy, ... |
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|
Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 65 | JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0 | ||
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Summary: City, Iowa 52242, and Targeted Genetics Corporation, Seattle, Washington 981014 Received 12 May 2000... /Accepted 14 July 2000 Adeno-associated virus (AAV) is a single-stranded DNA parvovirus that causes... controlling infection. In this study, we have examined endocytic and intracellular trafficking of AAV-2 using |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 66 | ELSEVIER Virus Research 48 (1997) 41-56 Structural and functional heterogeneity of integrated | ||
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Summary: of integrated recombinant AAV genomes Dongsheng Duan b, Krishna J. Fisher a,b, John F. Burda a,b, John F... November 1996 Abstract Adeno-associated Virus (AAV) has emerged as a promising vector for gene therapy... of this virus is based on studies evaluating wild type AAV or recombinant AAV which was ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 67 | JOURNAL OF VIROLOGY, June 2004, p. 63446359 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.63446359.2004 | ||
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Summary: . Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2... )-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain Carmen S. Peden,1,2,3 Corinna Burger,2... Genetics and Microbiology,4 Powell Gene Therapy Center,2 and McKnight ... |
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Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 68 | NATURE BIOTECHNOLOGY VOLUME 25 NUMBER 10 OCTOBER 2007 1111 and drugs that act directly on disease genes. | ||
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Summary: , a network analysis of the OMIM database of genetic associations showed that the genetic origins of most dis... . Rev. Genet. 5, 101113 (2004). 5. Wishart, D. et al. Nucleic Acids Res. 34, D668D672 (2006). 6. Goh... and hubs. AAV vectors and tumorigenicity Mark A Kay Chromosomal integration of ... |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 69 | Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina | ||
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Summary: Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer... October 2005 The short- and long-term effects of gene therapy using AAV-mediated RPE65 transfer to canine... . Results with AAV 2/2, 2/1, and 2/5 vector pseudotypes, human or canine RPE65 cDNA, and constitutive |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 70 | original article 524 www.moleculartherapy.org vol. 17 no. 3, 524537 mar. 2009 | ||
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Summary: Society of Gene Therapy Recombinant adeno-associated virus (rAAV) expresses no viral genes after... transduction. In addition, because the brain is relatively immunoprivileged, intracranial rAAV transduction may... be immunologically benign due to a lack of antigen presentation. However, pre- exposure to AAV allows neutralizing |
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Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 71 | Vectors of Gene Therapy KATHERINE PARKER PONDER, M.D. | ||
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Summary: of the genetic material into a cell is necessary to achieve the desired therapeutic effect. For gene transfer... , either a messenger ribonucleic acid (mRNA) or genetic material that codes for mRNA needs... piece of genetic material (>1kb) is required that includes the promoter sequences that activate |
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Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 72 | Gene Therapy (1999) 6, 14271437 1999 Stockton Press All rights reserved 0969-7128/99 $12.00 | ||
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Summary: damage including UV, hyd- of rAAV transduction. Furthermore, using electron spin res- roxyurea... and ionizing irradiation have been shown to aug- onance spectroscopy (ESR), we demonstrated that both ment rAAV... /or activation of cellular factors important in the inhibits the augmentation of rAAV transduction following |
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|
Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 73 | HUMAN GENE THERAPY 18:8187 (January 2007) Mary Ann Liebert, Inc. | ||
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Summary: recombination in vivo, using a trans- splicing dual vector genetic approach. Evidence suggests that AAV... Genetics Corporation. REFERENCES BERNS, K.I., and GIRAUD, C. (1996). Adeno-associated Virus (AAV) Vectors... . ENGELHARDT13 ABSTRACT We have previously demonstrated that hybrid adeno-associated viral ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 74 | original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 18 no. 5, 873880 may 2010 873 | ||
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Summary: model of MPS IIIB, neo- natal mice were treated with intracranial AAV2/5-NAGLU (AAV), syngeneic bone... marrow transplant (BMT), or both (AAV/BMT). All treatments resulted in some improve- ment in clinical... phenotype. Adeno-associated viral (AAV) treatment resulted in improvements in lifespan, motor ... |
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Source: Orrock, John - Department of Zoology, University of Wisconsin at Madison |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 75 | GENE THERAPY AAV-mediated factor IX gene transfer to skeletal muscle in patients with | ||
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Summary: GENE THERAPY AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe... of a recombinant adeno-associated viral (rAAV) vector ex- pressing F.IX. In this study we investi- gated the safety... hemophilia B (F.IX < 1%) due to a missense mutation were injected at mul- tiple intramuscular sites with an rAAV |
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|
Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 76 | JOURNAL OF VIROLOGY, Jan. 2005, p. 364379 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.364379.2005 | ||
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Summary: systems. For example, genetic modification of AAV capsid proteins and the identification of new AAV... capacity (less than 5 kb) of adeno-associated virus (AAV) vectors has been effectively doubled... ) sequences mediate intermolecular recombination of AAV genomes, with the goal of ... |
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|
Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 77 | HUMAN GENE THERAPY 16:781791 (July 2005) Mary Ann Liebert, Inc. | ||
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Summary: Recombinant adeno-associated virus 2 (rAAV2) has been extensively used as a gene delivery vector... - pression of transgenes. New rAAV serotypes have been characterized and demonstrated to have improved... - ties of rAAV that have been studied in the nervous system such as cell tropism, duration of transgene |
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|
Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 78 | original article 2114 www.moleculartherapy.org vol.15no.12,21142123dec.2007 | ||
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Summary: Society of Gene Therapy Biological Differences in rAAV Transduction of Airway Epithelia in Humans... , The University of Iowa, Iowa City, Iowa, USA; 2 The Center for Gene Therapy of Cystic Fibrosis and Other Genetic... Hopkins University, Baltimore, Maryland, USA; 6 Targeted Genetics Corporation, Seattle, Washington, USA |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 79 | Molecular Engineering of Viral Gene Delivery Vehicles | ||
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Summary: of peptides. The first study that attempted genetic re- targeting of AAV2 involved the fusion of a single... /22/08.Forpersonaluseonly. #12;Ad: Adenovirus AAV: Adeno- associated virus VAP: viral attachment protein Contents... 3). The two primary approaches currently employed to deliver the therapeutic ... |
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Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 80 | Preventive HIV Vaccines What is a vaccine? | ||
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Summary: Preventive HIV Vaccines What is a vaccine? A vaccine is a medical product designed to stimulate... your body's immune system in order to prevent or control an infection. An effective preventive vaccine... infection or make you sick. What is the difference between a preventive HIV vaccine ... |
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|
Source: Bezrukov, Sergey M. - Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development |
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Collection: Chemistry ; Biology and Medicine |
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| 81 | JOURNAL OF VIROLOGY, Apr. 2003, p. 47514759 Vol. 77, No. 8 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.8.47514759.2003 | ||
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Summary: genetic diseases (1, 12). Due to the relatively small packaging size of this single-stranded virus, AAV... with an AAV vector. Nat Genet. 24:257261. 13. Lee, S. E., R. A. Mitchell, A. Cheng, and E. A. Hendrickson... concatemerization of the recombinant adeno-associated virus (rAAV) ... |
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Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 82 | JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.15.69696976.2001 | ||
|
Summary: of recombinant AAV vectors. Nat. Genet. 16:270276. 35. Snyder, R. O., S. K. Spratt, C. Lagarde, D. Bohl, B... . KAY* Departments of Pediatrics and Genetics, Stanford University School of Medicine, Stanford... , California 94305 Received 15 February 2001/Accepted 29 April 2001 Recombinant adeno-associated virus ... |
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|
Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 83 | JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0 | ||
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Summary: January 1999/Accepted 30 March 1999 Recombinant adeno-associated virus (rAAV) vectors allow for sustained... expression of transgene products from mouse liver following a single portal vein administration. Here a rAAV... vector expressing human coagulation factor F.IX (hF.IX), AAV-EF1 -F.IX (hF.IX expression was controlled |
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|
Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 84 | Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene | ||
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Summary: with an AAV vector. Nat. Genet. 24, 257261 (2000). 4. Manno, C.S. et al. AAV-mediated factor IX gene transfer... , random adeno-associated viral (AAV) libraries that can be selected for a desired function. First, the AAV... extension process. The resulting PCR product is then cloned ... |
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|
Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 85 | Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant | ||
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Summary: Genetic Diseases, College of Medicine, University of Iowa, Iowa City, Iowa Differences in airway... fibrosis (CF) using murine models. In this context, recombinant adeno-associated virus (rAAV) type 2 and rAAV... epithelia (rAAV2 rAAV5) as compared with mouse lung ... |
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|
Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 86 | MOLECULAR THERAPY Vol. 4, No. 6, December 2001 Copyright The American Society of Gene Therapy | ||
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Summary: in patients with severe hemophilia B treated with an AAV vector. Nat. Genet. 24: 257261. 9. Yamazaki, Y., et... of Germline Transmission of Vector Sequences Following Systemic Administration of Recombinant AAV-2 Vector... , Philadelphia, Pennsylvania 19104, USA 3 Division of Human Genetics and 4 Department ... |
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|
Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 87 | A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Muller Cells | ||
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Summary: of AAV-mediated gene delivery towards other retinal degenerative diseases. Importantly, genetic... of genetic factors, and individualized treatment options for afflicted patients are limited and cost... , or intravitreal, injection of an efficient vehicle such as an adeno- associated viral vector (AAV). ... |
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|
Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley |
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Collection: Materials Science ; Chemistry |
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| 88 | Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1408314088, December 1997 | ||
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Summary: A recombinant adeno-associated virus (rAAV) vector capable of infecting cells and expressing rat glial cell line... of a potent cytomegalovirus (CMV) immediate early promoter (AAV-MD-rGDNF) was constructed. Two ex- periments... were performed to evaluate the time course of expression of rAAV-mediated GDNF protein expression |
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Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 89 | Sites in the AAV5 capsid tolerant to deletions and tandem duplications Kaoru Hida a | ||
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Summary: Sites in the AAV5 capsid tolerant to deletions and tandem duplications Kaoru Hida a , Sang Y. Won b... January 2010 Available online 25 January 2010 Keywords: Directed evolution AAV Viral gene delivery a b... s t r a c t Gene therapy vectors based on adeno-associated virus (AAV) have shown much promise |
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|
Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University |
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Collection: Biology and Medicine ; Biotechnology ; Chemistry |
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| 90 | JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0 | ||
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Summary: Adeno-associated viral (AAV) vectors have demonstrated great utility for long-term gene expression... in muscle tissue. However, the mechanisms by which recombinant AAV (rAAV) genomes persist in muscle tissue... remain unclear. Using a recombinant shuttle vector, we have demonstrated that circularized rAAV ... |
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|
Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 91 | Practical Aspects of the Development of ex Vivo and in Vivo Gene Therapy for Parkinson's Disease | ||
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Summary: genetically modified fibroblasts and in vivo applications using AAV vectors are likely to be safe based... grafting genetically modified autologous cells or introducing genetic material into cells in situ using... -associated (AAV) viral vectors expressing b-ga- lactosidase or tyrosine ... |
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|
Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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|
Collection: Biology and Medicine |
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| 92 | Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Gene therapy for hemophilia | ||
|
Summary: -associated virus vector (AAV vector), adenoviral vector, gene therapy, hemophilia, retroviral vector Curr Opin... -mail: kponder@im.wustl.edu Current Opinion in Hematology 2006, 13:301307 Abbreviations AAV adeno... . The status of the liver-directed adeno-associated virus (AAV) vector-mediated gene therapy trial in humans |
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|
Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 93 | Heparin binding induces conformational changes in Adeno-associated virus Hazel C. Levy a | ||
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Summary: Lafayette, IN 47907, USA c Department of Molecular Genetics and Microbiology and Powell Gene Therapy Center... Heparin sulfate a b s t r a c t Adeno-associated virus serotype 2 (AAV2) uses heparan sulfate proteoglycan... as a cell surface-attachment receptor. In this study the structures of AAV2 alone and complexed with heparin |
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|
Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 94 | RAPID COMMUNICATION Structural Analysis of Adeno-Associated Virus Transduction Circular Intermediates | ||
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Summary: , 1999; accepted May 24, 1999 Recombinant adeno-associated virus (rAAV) has recently been demonstrated... of the ITR arrays. To gain further insight into potential mechanisms by which AAV circular genomes are formed... sequences. The most predominant form consisted of a structure similar to that of previously generated AAV |
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|
Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 95 | JOURNAL OF VIROLOGY, Mar. 2005, p. 36063614 Vol. 79, No. 6 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.6.36063614.2005 | ||
|
Summary: Markus Grompe,4,6 and Mark A. Kay1,3 Departments of Pediatrics1 and Genetics,3 Stanford University School... , National Institutes of Health,5 Bethesda, Maryland; and Departments of Molecular and Medical Genetics4... 2004 Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low |
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|
Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 96 | JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0 | ||
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Summary: , Iowa Received 15 April 1999/Accepted 26 July 1999 Long-term recombinant AAV (rAAV) transgene expression... in muscle has been associated with the molecular conversion of single-stranded rAAV genomes to high... form remain to be defined. To this end, we tested whether concatamerization of rAAV circular |
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|
Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa |
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Collection: Biology and Medicine |
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| 97 | MOLECULAR THERAPY Vol. 6, No. 3, September 2002 Copyright The American Society of Gene Therapy | ||
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Summary: (rAAV2) Vectors Renius Owen IV, Ronald J. Mandel, Chandramohan V. Ammini, Thomas J. Conlon, Douglas S... , Biochemistry and Molecular Biology, Molecular Genetics and Microbiology, The General Clinical Research Center... , The Center for Mammalian Genetics, The Genetics Institute, and The Powell Gene Therapy ... |
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|
Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida |
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Collection: Biology and Medicine |
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| 98 | JOURNAL OF VIROLOGY, Nov. 2002, p. 1134311349 Vol. 76, No. 22 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.22.1134311349.2002 | ||
|
Summary: IX in haemophilia B patients treated with an AAV vector. Nat. Genet. 24:257261. 17. Kessler, P. D... . 1998. The kinetics of rAAV integration in the liver. Nat. Genet. 19:1315. 22. Nakai, H., R. W. Herzog... of recombinant AAV vectors. Nat. Genet. 16:270276. 31. ... |
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|
Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 99 | Adeno-Associated Virus Gene Repair Corrects a Mouse Model of Hereditary Tyrosinemia In Vivo | ||
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Summary: Grompe1,5 Adeno-associated virus (AAV) vectors are ideal for performing gene repair due to their ability... model of the metabolic disease hereditary tyrosinemia type I was used to test whether targeted AAV... and adult mice were treated with AAV serotypes 2 and 8 carrying a wild-type genomic sequence for repairing |
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Source: Kay, Mark A. - Department of Genetics, Stanford University |
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Collection: Biology and Medicine |
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| 100 | Novel perspectives for iNflueNza vacciNe formulatioN aNd admiNistratioN | ||
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Summary: culture based vaccines · Plant based vaccines · Reverse genetics (for faster generation of seed strains... -living, non-genetically modified Lactococcus lactis vaccine carrier induces systemic and local Th1-type... Novel perspectives for iNflueNza vacciNe formulatioN ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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