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Sample search results for: growth factor ii

 

1

Original article Insulin-like growth factor II (IGF-II) mRNA

  Computer Technologies and Information Sciences Websites

Summary: Original article Insulin-like growth factor II (IGF-II) mRNA expression during skeletal muscleRNA expression and low plasma IGF-11 levels in both genetic types. The second step of mus- cle cell-II was reduced. @ InraBlsevier, Paris muscle / bovine / mRNA / insulin-like growth factor-II / double

Boyer, Edmond

2

Selective Expression of Insulin-Like Growth Factor II in the Songbird Brain

  Biology and Medicine Websites

Summary: songbirds. To address the molecular processes that gov- ern this replacement, we cloned the zebra finchSelective Expression of Insulin-Like Growth Factor II in the Songbird Brain Martin Holzenberger,2 insulin-like growth factor II (IGF-II) cDNA, a factor known to regulate neu- ronal development

Scharff, Constance

3

Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes

  Environmental Sciences and Ecology Websites

Summary: Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes comparative evolutionary analyses of the insulin-like growth factor II (IGF2) gene in teleost fishes. Our of placental livebearing fishes, suggesting that selection on IGF2 function is ongoing in placental species

Hrbek, Tomas - Department of Biology, Universidad de Puerto Rico

4

Transforming growth factor -receptor II protein expression in benign prostatic hyperplasia is associated

  Physics Websites

Summary: 1 Transforming growth factor -receptor II protein expression in benign prostatic hyperplasia is associated with prostate volume and inflammation. Descazeaud A, Weinbreck N, Robert G, Vacherot F, Abbou CC prostatic hyperplasia (BPH) using immunohistochemistry analysis, and to compare the analysis with phenotypic

Paris-Sud XI, Université de

5

RAPID COMMUNICATIONS A Unique Family of Endothelial Cell Polypeptide Mitogens: The Antigenic and Receptor Cross-Reactivity of Bovine Endothelial Cell Growth Factor, Brain-derived Acidic Fibroblast Growth Factor, and Eye-derived Growth Factor-II

  CiteSeer

Summary: ABSTRACT Bovine brain, hypothalamus, pituitary, and retina contain potent anionic polypeptide mitogens for endothelial cells. Immunological assays using murine monoclonal antibodies against bovine endothelial cell growth factor (ECGF) and radioreceptor assays using [1251]ECGF were performed to determine the cross-reactivity of ECGF with bovine acidic pl brain-derived fibroblast growth factor (acidic FGF) and bovine eye-derived growth factor-II (EDGF-II). We observed that acidic FGF and EDGF-II are recognized by anti-ECGF monoclonal antibodies and compete with [1251] ECGF for receptor occupancy. Furthermore, the biological activity of ECGF, acidic FGF, and EDGF-II is potentiated by the glycosylaminoglycan, heparin. These results argue that ECGF, acidic FGF, and EDGF-II belong to a common family of polypeptide growth factors. Several growth factors of peptidic nature have been isolated and purified from bovine neural tissue (1, 4-6, 9, 10, 14-19, 23, 24). These polypeptides share common biological properties since they are all potent mitogens for murine BALB/c 3T3 cells in vitro. In addition, several of these polypeptide mitogens stimulate endothelial cell proliferation in vitro (1,

Alain B. Schreiber; John Kenney; Joseph Kowalski; Kenneth A. Thomas; Guillermo Gimenez-gallego; Marl Rios-candelore; Jerry Di Salvo; Denis Barritault; Jose Courty; S Yves Courtois; Tevle Mehlman; Robert Friesel; A Warren Johnson; Thomas Maclag Ii

6

Original article Evidence that growth factors IGF-I, IGF-II

  Physics Websites

Summary: maturation of porcine oocytes via intracellular protein kinase A Alexander V. SIROTKINa*, Janka DUKESOVÁa of growth factors and protein kinase A (PKA)-dependent intracellular mechanisms in the control of nuclear ng.mL­1 medium) and inhibitors of PKA (Rp-cAMPS or KT5720; 100 ng.mL­1). Stages of meiosis were

Paris-Sud XI, Université de

7

The SCET_II and factorization

  HEP - Phenomenology (arXiv)

Summary: We reformulate the soft-collinear effective theory which includes the collinear quark and soft gluons. The quark form factor is used to prove that SCET$_{\\rm II}$ reproduces the IR physics of the full theory. We give a factorization proof in deep inelastic lepton-hadron scattering by use of the position space formulation.

Zheng-Tao Wei
2004-02-03

8

Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-? type II receptor (sTGF?RII) gene transfer

  MIT - DSpace

Summary: Purpose: To explore (i) the potential of polyethylenimine (PEI)-DNA nanoparticles as a vector for delivering genes into human corneal fibroblasts, and (ii) whether the nanoparticle-mediated soluble extracellular domain of ...

Sharma, Ajay

9

Singular subfactors of II_1 factors

  Texas A&M University - TxSpace

Summary: Page 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. PRELIMINARIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.1. Background and Notation . . . . . . . . . . . . . . . . . . . . 4 2.2. Group von Neumann... Algebras, Crossed Products, and Ex- amples of II1 Factors . . . . . . . . . . . . . . . . . . . . . . . 6 2.2.1.Group von Neumann Algebras . . . . . . . . . . . . . 6 2.2.2.Crossed Products . . . . . . . . . . . . . . . . . . . . 7 2.3. The Standard...

Wiggins, Alan Daniel
2007-09-17

10

Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin,

  Biology and Medicine Websites

Summary: Vised Manuscript ReceiVed April 23, 2002 ABSTRACT: Human insulin-like growth factors I and II (hIGF-I, h of the structural integrity of hIGF-I in relation to its biological function. Human insulin-like growth factor I (hStructural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin


11

Fibroblast growth factors, their receptors and signaling

  CiteSeer

Summary: Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embryonic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.

C J Powers; S W Mcleskey; A Wellstein
2000-01-01

12

Growth factor parametrization in curved space

  HEP - Phenomenology (arXiv)

Summary: The growth rate of matter perturbation and the expansion rate of the Universe can be used to distinguish modified gravity and dark energy models in explaining cosmic acceleration. We explore here the inclusion of spatial curvature into the growth factor. We expand previous results using the approximation $\\Omega_{m}^\\gamma$ and then suggest a new form, $f_a=\\Omega_m^\\gamma+(\\gamma-4/7)\\Omega_k$, as an approximation for the growth factor when the curvature $\\Omega_k$ is not negligible, and where the growth index $\\gamma$ is usually model dependent. The expression recovers the standard results for the curved and flat $\\Lambda$CDM and Dvali-Gabadadze-Porrati models. Using the best fit values of $\\Omega_{m0}$ and $\\Omega_{k0}$ to the expansion/distance measurements from Type Ia supernovae, baryon acoustic oscillation, WMAP5, and $H(z)$ data, we fit the growth index parameter to current growth factor data and obtain $\\gamma_{\\Lambda}(\\Omega_{k} \

Yungui Gong; Mustapha Ishak; Anzhong Wang
2009-07-01

13

Growth factor parametrization and modified gravity

  General Relativity & Quantum Cosmology (arXiv)

Summary: The growth rate of matter perturbation and the expansion rate of the Universe can be used to distinguish modified gravity and dark energy models in explaining the cosmic acceleration. The growth rate is parametrized by the growth index $\\gamma$. We discuss the dependence of $\\gamma$ on the matter energy density $\\Omega$ and its current value $\\Omega_0$ for a more accurate approximation of the growth factor. The observational data, including the data of the growth rate, are used to fit different models. The data strongly disfavor the Dvali-Gabadadze-Porrati model. For the dark energy model with a constant equation of state, we find that $\\Omega_0=0.27\\pm 0.02$ and $w=-0.97\\pm 0.09$. For the $\\Lambda$CDM model, we find that $\\gamma=0.64^{+0.17}_{-0.15}$. For the Dvali-Gabadadze-Porrati model, we find that $\\gamma=0.55^{+0.14}_{-0.13}$.

Yungui Gong
2008-12-16

14

Nutrients versus growth factors in mTORC1 activation

  MIT - DSpace

Summary: Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several ...

Efeyan, Alejo

15

Growth factor in f(T) gravity

  General Relativity & Quantum Cosmology (arXiv)

Summary: We derive the evolution equation of growth factor for the matter over-dense perturbation in $f(T)$ gravity. For instance, we investigate its behavior in power law model at small redshift and compare it to the prediction of $\\Lambda$CDM and dark energy with the same equation of state in the framework of Einstein general relativity. We find that the perturbation in $f(T)$ gravity grows slower than that in Einstein general relativity if $\\p f/\\p T>0$ due to the effectively weakened gravity.

Rui Zheng; Qing-Guo Huang
2011-02-23

16

ORIGINAL RESEARCH Neuropeptides, Growth Factors, and Cytokines: A Cohort

  Biology and Medicine Websites

Summary: ). These included cytokines, growth factors and hormones, as well as converting enzymes, or protease inhibitors in the adrenal medulla. Keywords Adrenal medulla Á Chromaffin cell Á Cytokine Á Growth factor Á Hormone ÁORIGINAL RESEARCH Neuropeptides, Growth Factors, and Cytokines: A Cohort of Informational Molecules

Baker, Chris I.

17

Review Lactoferrin – A Novel Bone Growth Factor

  CiteSeer

Summary: Lactoferrin is an iron-binding glycoprotein that belongs to the transferrin family. It is present in breast milk, in epithelial secretions, and in the secondary granules of neutrophils. In healthy subjects lactoferrin circulates at concentrations of 2-7 x 10-6 g/ml. Lactoferrin is a pleiotropic factor with potent antimicrobial and immunomodulatory activities. Recently, we have shown that lactoferrin can also promote bone growth. At physiological concentrations, lactoferrin potently stimulates the proliferation and differentiation of primary osteoblasts and also acts as a survival factor inhibiting apoptosis induced by serum withdrawal. Lactoferrin also affects osteoclast formation and, in murine bone marrow culture, lactoferrin potently inhibits osteoclastogenesis. In vivo, local injection of lactoferrin above the hemicalvaria of adult mice results in substantial increases in the dynamic histomorphometric indices of bone formation and bone area. The mitogenic effect of lactoferrin in osteoblast-like cells is mediated mainly through LRP1, a member of the family of low-density lipoprotein receptor-related proteins that are primarily known as endocytic receptors. Using confocal laser scanning microscopy, we demonstrated that fluorescently labeled lactoferrin is endocytosed and can be visualized in the cytoplasm of primary osteoblastic cells. Lactoferrin also induces activation of p42/44 MAPK signaling in primary osteoblasts, but the two pathways seem to operate independently as activation of MAPK signaling, but not endocytosis, is necessary for the mitogenic effect of lactoferrin. We conclude that lactoferrin may have a physiological role in bone growth and healing, and a potential therapeutic role as an anabolic factor in osteoporosis.

Dorit Naot; Phd Andrew Grey; Md Ian; R Reid; Jillian Cornish

18

Original article Effect of growth factors on proliferation, apoptosis

  Computer Technologies and Information Sciences Websites

Summary: that cAMP/PKA may be a mediator of the action of growth factors on these cells. The differential effects by ovarian cells [1, 5, 13, 15, 29] but also stimulate oocyte maturation [10, 11, 20, 21, 26, 28, 31]. GrowthOriginal article Effect of growth factors on proliferation, apoptosis and protein kinase

Boyer, Edmond

19

A module of negative feedback regulators defines growth factor signaling

  Biology and Medicine Websites

Summary: of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growthA module of negative feedback regulators defines growth factor signaling Ido Amit1,9, Ami Citri1 and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor


20

Insulin-Like Growth Factor Family and Combined Antisense Approach in Therapy of Lung Carcinoma

  CiteSeer

Summary: Background: Perturbation in a level of any peptide from insulin-like growth factor (IGF) family (ligands, receptors, and binding proteins) seems to be implicated in lung cancer formation; IGF ligands and IGF-I receptor through their mitogenic and anti-apoptotic action, and the mannose 6-phosphate/insulin-like growth factor II receptor (M6-P/IGF-IIR) possibly as a tumor suppressor. Materials and Methods: To determine the identity, role, and mutual relationship of IGFs in lung cancer growth and maintenance, we examined IGF’s gene (by RT-PCR) and protein (by immunohistochemistry) expression in 69 human lung carcinoma tissues. We also examined IGF-I receptor numbers (Scatchard analysis) and IGF-II production and release (by Western blot) in IGF-II/IGF-IR mRNA

Jasminka Paveli?; Ljubomir Paveli?
2002-01-01

21

Note on Integer Factoring Algorithms II

  Math Preprints (arXiv)

Summary: This note introduces a new class of integer factoring algorithms. Two versions of this method will be described, deterministic and probabilistic. These algorithms are practical, and can factor large classes of balanced integers N = pq, p < q < 2p in superpolynomial time. Further, an extension of the Fermat factoring method is proposed.

N. A. Carella
2007-02-08

22

Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm

  MIT - DSpace

Summary: Specific interactions between heparan sulfate glycosaminoglycans (HSGAGs) and proteins are central to a wide range of biological processes such as anticoagulation, angiogenesis and growth factor activation. The specificity ...

Kwan, Chi-Pong, 1973-
2002-01-01

23

Masas and Bimodule Decompositions of II_1 Factors

  Texas A&M University - TxSpace

Summary: The measure-multiplicity-invariant for masas in II_1 factors was introduced by Dykema, Smith and Sinclair to distinguish masas that have the same Pukanszky invariant. In this dissertation, the measure class (left...

Mukherjee, Kunal K.
2010-10-12

24

Original article Insulin-like growth factorI during growth in bulls

  Physics Websites

Summary: Original article Insulin-like growth factorI during growth in bulls H. Ronge J. Blum Université de-4-1988, accepted 24-11-1988) Summary ― In 10 bulls, changes in blood plasma concentrations of insulin the growth period. An age-dependent increase was also observed for blood levels of insulin, thyroxine

Paris-Sud XI, Université de

25

Experimental estimate of the diffusivity of Vascular Endothelial Growth Factor

  MIT - DSpace

Summary: The diffusivity of Vascular Endothelial Growth Factor (VEGF) is a number that is very important in determining the transport of VEGF. The transport of VEGF determines crucial processes such as angiogenesis and vasculogenesis. ...

Núñez, Daniel A
2006-01-01

26

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins

  MIT - DSpace

Summary: No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target. A panel of fibronectin-based domains was engineered to bind with picomolar ...

Hackel, Benjamin J.

27

Characterizing and engineering antibodies against the epidermal growth factor receptor

  MIT - DSpace

Summary: Epidermal growth factor receptor (EGFR) signaling leads to cellular proliferation and migration, and thus EGFR dysregulation can significantly contribute to the survival of tumor cells. Aberrant EGFR signaling due to ...

Chao, Ginger
2008-01-01

28

Shear stress magnitude and directionality modulate growth factor gene expression in

  Biotechnology Websites

Summary: nitric oxide synthase (NOS3), platelet-derived growth factor A, platelet-derived growth factor B (PDGFB) transcriptional changes in multiple genes, including elevated END1 (4.1 0.5), platelet-derived growth factor A (1

Passerini, Tony

29

IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity

  CiteSeer

Summary: Abstract. During wound healing, fibroblasts are recruited from the surrounding tissue to accomplish repair. The requisite migration and proliferation of the fibroblasts is promoted by growth factors including those that activate the epidermal growth factor receptor (EGFR). Counterstimulatory factors in wound fluid are postulated to limit this response; among these factors is the ELR-negative CXC chemokine, interferon inducible protein-10 (IP-10). We report here that IP-10 inhibited EGF- and heparin-binding EGF-like growth factor–induced Hs68 human dermal fibroblast motility in a dose-dependent manner (to 52 % and 44%, respectively, at 50 ng/ml IP-10), whereas IP-10 had no effect on either basal or EGFR-mediated mitogenesis (96 ? 15 % at 50 ng/ml). These data demonstrate for the first

Hidenori Shiraha; Angela Glading; Kiran Gupta; Alan Wells
1999-01-01

30

Explaining Economic Growth: Factor Accumulation, Total Factor Productivity Growth, and Production Efficiency Improvement

  Engineering Websites

Summary: examines cross-country patterns of economic growth by estimating a stochastic frontier production function criticism of the neoclassical growth model comes from its failure to explain cross-country differences

Ahmad, Sajjad

31

Expression levels of transcription factors in Escherichia coli: growth phase-and growth

  Biology and Medicine Websites

Summary: Expression levels of transcription factors in Escherichia coli: growth phase- and growth condition in Escherichia coli is controlled by regulating the utilization of a limited number of RNA polymerases between). On the basis of the complete genome sequence of several model Escherichia coli strains, the whole set of about

Dever, Jennifer A.

32

Synergism between a human growth hormone-releasing factor and thyrotropin-releasing factor on growth hormone release in relation

  Computer Technologies and Information Sciences Websites

Summary: on growth hormone release in relation with the stage of lactation of Holstein dairy cows (1) H. LAPIERRE D vaches Holstein en début, au pic et en fin de lactation (18, 72 et 210 jours, respectivement) ont reçu lactation. Human growth hormone-releasing factor (hGRF) and its fragment, (1-29)NH2, stimulate GH release

Boyer, Edmond

33

An Atomic Resolution Structure for Human Fibroblast Growth Factor 1

  Biology and Medicine Websites

Summary: An Atomic Resolution Structure for Human Fibroblast Growth Factor 1 Matthew J. Bernett. The backbone atoms of each structurally conserved region of the symmetry-related subdomains in FGF-1 overlay and Biochemistry, Florida State University, Tallahassee, Florida ABSTRACT A 1.10-Å atomic resolution X

Blaber, Michael

34

ARTICLE IN PRESS Platelet-derived growth factor regulates oligodendrocyte

  Biology and Medicine Websites

Summary: ARTICLE IN PRESS Platelet-derived growth factor regulates oligodendrocyte progenitor numbers such as multiple sclerosis, it will be important to understand the mechanisms that control oligodendrocyte­xxx sclerosis (MS) (Franklin, 2002; Ludwin, 1987). A major source of remyelinating oligodendrocytes is thought

Richardson, William D.

35

Discovering Small Molecule Ligands of Vascular Endothelial Growth Factor

  Materials Science Websites

Summary: -based assay platform that we used to identify inhibitors of vascular endothelial growth factor (VEGF)­ kinase detects binding of a target protein with SMM and identifies ligands to the protein as inhibitor candidates Institute and found 12 inhibitors to VEGF­KDR (VEGFR2) interactions with IC50 ranging from 0.3 to 60 l

Zhu, Xiangdong

36

Modelling hematopoiesis mediated by growth factors: Delay equations describing periodic

  Computer Technologies and Information Sciences Websites

Summary: and reg- ulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed to carry out explanation on some blood diseases, characterized by oscillations in circulating blood cells. A system of three differential

Boyer, Edmond

37

Crystallisation in flow Part II: Modelling crystal growth kinetics controlled by boundary layer thickness

  Physics Websites

Summary: 1 Crystallisation in flow Part II: Modelling crystal growth kinetics controlled by boundary layer already done in the case of a flow parallel to the crystal face. This crystal growth model is applied, based on crystal growth processes. The idea that mineral shapes and textures are related

Paris-Sud XI, Université de

38

A thermodynamical model of molecular beam epitaxy, application to the growth of II VI semiconductors

  Computer Technologies and Information Sciences Websites

Summary: 457 A thermodynamical model of molecular beam epitaxy, application to the growth of II VI to a set of equations which can be solved to predict the growth rate, the x value of a ternary alloy of this model resides in its ability to predict the effects of the modification of one of the growth parameter

Boyer, Edmond

39

Mammalian Transforming growth factor-bs: Smad signaling and physio-pathological roles

  Physics Websites

Summary: 1 Mammalian Transforming growth factor-bs: Smad signaling and physio- pathological roles Delphine, Transforming Growth Factor-b (TGF-b) has emerged as a family of growth factors involved in essential physiological processes, including embryonic development, differentiation, tissue repair and cell growth control

Paris-Sud XI, Université de

40

Factors Inhibiting Personal Growth When Teaching Academically Diverse Classes

  University of Kansas - KU ScholarWorks

Summary: . As factors impeding growth, teachers identified (a) feelings of despair and dissatisfaction over lack of control, dated equipment and materials, and fatfgue, (b) time constraints and problems given heavy work loads, and (c) discipline issues (e.g., "police..., & Schuler, 1986) and (b) a source of ideas about teaching (Kasten, 1984) . In reference to teacher-administrator relationships, Litt and Turk (1985) found that 291 high school teachers identified lack of feedback from supervisors and no control over...

Lenz, B. Keith; Melvin, Jeff; Kissam, Brenda; Bulgren, Janis; Roth, Janet
1992-08-01

41

The effects of growth factors on testicular germ cell apoptosis in the stallion

  Texas A&M University - TxSpace

Summary: recombinant growth factors, stem cell factor (SCF), leukemia inhibiting factor (LIF), granulocyte macrophage-colony stimulating factor (GM-CSF), and one hormone, estradiol (E?), alone or in combination, to prevent apoptosis of germ cells in short-term equine...

Donnelly, Casey Leanne
2002-01-01

42

Platelet-derived growth factor-a receptor activation is required for human cytomegalovirus infection

  Chemistry Websites

Summary: LETTERS Platelet-derived growth factor-a receptor activation is required for human cytomegalovirus understood4 . Here we show that platelet-derived growth factor-a receptor (PDGFR-a) is specif- ically

Cai, Long

43

Argonaute-2 Expression Is Regulated by Epidermal Growth Factor Receptor and Mitogen-Activated

  Biology and Medicine Websites

Summary: -life studies using cycloheximide indicated that EGF enhanced, whereas U0126 decreased, Ago2 protein stability, cycloheximide; DPN, diarylpropionitrile; EGF, epi- dermal growth factor; EGFR, epidermal growth factor receptor

Terasaki, Mark

44

Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis*S

  Materials Science Websites

Summary: the progression of degenerative disorders like osteoarthritis, in which the metabolic activity of articular chon carti- lage repair include fibroblast growth factors (FGFs),1 platelet- derived growth factor, bone

Buschmann, Michael

45

On the fundamental group of II1 factors and equivalence relations arising from group actions

  Mathematics Websites

Summary: that there exist II1 factors of the form M = L (X) F such that the fundamental group of M is R+, but M B( 2 (N effect of the uniqueness of the amenable II1 factor [5] and of the amenable II1 equivalence relation [7 ergodic p.m.p. action F X [15]. Moreover, many factors of the form L (X) Fn were shown to have trivial

Vaes, Stefaan

46

Cells, growth factors and bioactive surface properties in a mechanobiological model of implant healing

  Computer Technologies and Information Sciences Websites

Summary: Cells, growth factors and bioactive surface properties in a mechanobiological model of implant on the implant surface. When the variation of structural fraction to cell motility and growth factor synthesis: implant fixation, mechanobiology, growth factor, osteoblast, transport in porous media, biomaterial Word

Boyer, Edmond

47

Role of insulin-like growth factor 1 receptor signalling in cancer O Larsson*,1

  Chemistry Websites

Summary: Minireview Role of insulin-like growth factor 1 receptor signalling in cancer O Larsson*,1 Stockholm, Sweden The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer years implicates a crucial role of insulin-like growth factor 1 (IGF-1) signalling in development

Cai, Long

48

Bovine colostrum as substrate for the preparation of growth factor-enriched

  Physics Websites

Summary: .90). The greatest decreases in the concentrations of the three growth factors (78­84%) were observed within 24­48 hNote Bovine colostrum as substrate for the preparation of growth factor-enriched protein extracts of growth factor-enriched bioactive protein extracts derived from colostrum are proposed for the treatment

Paris-Sud XI, Université de

49

Delivering Heparin-Binding Insulin-Like Growth Factor 1 with Self-Assembling Peptide Hydrogels

  MIT - DSpace

Summary: Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ...

Miller, Rachel E.

50

Deep-Sea Research II 50 (2003) 635653 Phytoplankton growth and biological response to iron

  Geosciences Websites

Summary: Deep-Sea Research II 50 (2003) 635­653 Phytoplankton growth and biological response to iron to determine the community response to added iron and zinc and their effect on phytoplankton growth. Seawater was collected into acid-cleaned 20-l polycarbonate carboys and incubated with varying additions of iron and zinc

Wang, Wendy

51

Brief Detiaitive Report Growth Hormone and Insulln-like Growth Factor I Induce Immunoglobulin (Ig)E and IgG4 Production

  CiteSeer

Summary: We studied the effects of growth hormone (GH), insulin-like growth factor I (IGF-t), IGF-II, and insulin on human immunoglobulin E (IgE) and IgG4 production. GH and IGF-I induced IgE and IgG4 production by normal donors ' mononuclear cells (MNC) depleted of slgE + and slgG4 + B cells without affecting IgM, IgG1, IgG2, IgG3, IgA1, or IgA2 production, whereas IGF-II and insulin failed to do so. GH-induced IgE and IgG4 production was specific, and was not mediated by IGF-I, interleukin 4 (IL-4), or IL-13, since it was blocked by anti-GH antibody

Human B Cells; H. Kimata; M. Fujimoto

52

Effects of hypothalamic hormones (GRF, TRH, Somatostatin) and insulin-like growth factor I on growth hormone

  Physics Websites

Summary: Effects of hypothalamic hormones (GRF, TRH, Somatostatin) and insulin-like growth factor I on growth hormone secretion from prepubertal male lamb pituitary cultures Monique M. BLANCHARD Cynthia G hormone-releasing factor (GRF 1-44) stimulated GH release in a dose-related manner : the maximal effective

Paris-Sud XI, Université de

53

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response

  Chemistry Websites

Summary: Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element endothelial growth factor (VEGF) and its receptors have been implicated as key factors in tumor angiogenesis (HRE) was found to disrupt hypoxia-induc- ible factor (HIF) binding to HRE. In cultured HeLa cells

Stoltz, Brian M.

54

Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells.

  Computer Technologies and Information Sciences Websites

Summary: -binding epidermal growth factor-like growth factor (HB-EGF) is a growth factor for malignant plasma cells plasma cells or plasmablastic cells. AREG stimulated IL-6 production and growth of bone marrow stromal cells. We recently found that one of the members of the epidermal growth factor (EGF) family, HB- EGF

Boyer, Edmond

55

Some properties of factorized Lie algebras II 24 August 2012

  Mathematics Websites

Summary: A, HascB HascL. [3] Factorized Lie algebras ([10, Lemma 1]) L factorized Lie algebra by A and B H L factorized subalgebra of L factorized in L A B factorized subalgebra of L ([10, Lemma 2]) L = A + B (1) A H B H H factorized in L (2) A B = 0 H A H B H factorized in L 2 #12;([10, Lemma 3]) L factorized

Yoshii, Yoji

56

Unique Cartan decomposition for II1 factors arising from arbitrary actions of free groups

  Mathematics Websites

Summary: Unique Cartan decomposition for II1 factors arising from arbitrary actions of free groups by Sorin ergodic probability measure preserving action Fn (X, µ) of a free group on n generators Fn, 2 n conjugacy. We deduce that group measure space II1 factors arising from actions of free groups with different

Vaes, Stefaan

57

Misorientation texture development during grain growth. Part II: Theory

  Materials Science Websites

Summary: in the current work. In what follows we will discuss a new model for MDF evolution during grain growth; accepted 17 August 2009 Available online 7 October 2009 Abstract A critical event model for the evolution as a dense polycrystalline magnesia sam- ple. The steady-state equation of our model appears to be a good fit

Rohrer, Gregory S.

58

Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila

  Biology and Medicine Websites

Summary: Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting by binding to cell surface receptors and activating signal transduction pathways. However, growth could also effect on growth of several Drosophila cell types, and that ADGFs stimulate cell growth by an indirect

?urovec, Michal

59

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

  MIT - DSpace

Summary: Due to its common dysregulation in epithelial-based cancers and extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) is a highly validated target for anticancer therapies. There ...

Spangler, Jamie Berta

60

Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies

  MIT - DSpace

Summary: Due to its common dysregulation in epithelial-based cancers and the extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) has long been an attractive target for monoclonal antibodies. ...

Spangler, Jamie Berta
2011-01-01

61

The Confluent System Formalism: II. The Growth History of Objects

  Astrophysics (arXiv)

Summary: With the present paper we conclude the presentation of a semianalytical model of hierarchical clustering of bound virialized objects formed by gravitational instability from a random Gaussian field of density fluctuations. In paper I, we introduced the basic tool, the so-called ``confluent system'' formalism, able to follow the evolution of bound virialized objects in the peak model. This was applied to derive the mass function of objects. In the present paper, we calculate other important quantities characterizing the growth history of objects. This model is compared with a similar one obtained by Lacey \\& Cole (1993) following the Press \\& Schechter (1974) approach. The interest of the new modeling presented here is twofold: 1) it is formally better justified as far as peaks are more reasonable seeds of objects than the indetermined regions in the Press \\& Schechter prescription, and 2) it distinguishes between merger and accretion enabling us to unambiguously define the formation and destruction of objects and to estimate growth rates and characteristic times not available in the previous approach.

Alberto Manrique; Eduard Salvador-Sole
1996-03-09

62

DSIF, a novel transcription elongation factor that regulates RNA polymerase II

  Biology and Medicine Websites

Summary: DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, Boston, Massachusetts 02115 USA We report the identification of a transcription elongation factor from He with the transcription inhibitor 5,6-dichloro-1- -D-ribofuranosylbenzimidazole (DRB). This factor, termed DRB sensitivity


63

Molecular Cloud Structure in the Magellanic Clouds: II. CO-to-H2 Conversion Factor

  Physics Websites

Summary: Molecular Cloud Structure in the Magellanic Clouds: II. CO-to-H2 Conversion Factor Soojong Pak Conversion Factor in the Magellanic Clouds Neglecting the micro-turbulent width of the CO line, the CO-to-H2 conversion factor, X, can be expressed by the radius of the neutral cloud, Rcloud: X = N(H2) I(CO) / Mcloud L

Pak, Soojong

64

TWO-FACTORIZATIONS OF SMALL COMPLETE GRAPHS II: THE CASE OF 13 VERTICES

  Mathematics Websites

Summary: TWO-FACTORIZATIONS OF SMALL COMPLETE GRAPHS II: THE CASE OF 13 VERTICES F. Franek Department possible types of 2- factorizations of the complete graph K13, there exists at least one solution. We also enumerate all nonisomorphic solutions to the Oberwolfach problem OP(13;3,3,3,4). 1. Introduction A 2-factor

Franek, Frantisek

65

Nucleation and growth in one dimension. II. Application to DNA replication kinetics

  Materials Science Websites

Summary: of data, allowing the extraction of detailed statistical quantities. Since the DNA work provides a modelNucleation and growth in one dimension. II. Application to DNA replication kinetics Suckjoon JunS6 Received 30 July 2004; published 21 January 2005 Inspired by recent experiments on DNA


66

Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol

  CiteSeer

Summary: Although it is known that the lung undergoes compensatory growth after pulmonary resection, mechanisms by which lung cells exhibit compensatory proliferation are not well defined. We investigated the involvement of hepatocyte growth factor (HGF) in postpneumonectomy compensatory lung regeneration in mice, because HGF has mitogenic and morphogenic actions on lung epithelial cells. Following left pneumonectomy, alveolar and airway epithelial cells underwent compensatory DNA synthesis, reaching maximal levels 5 d after the surgery. Before changes in DNA synthesis in lung epithelial cells, expression of HGF mRNA and protein levels in the remaining lung, liver, and kidney were changed in response to left pneumonectomy, and these changes were associated with postoperative increases in plasma HGF levels. c-Met/HGF receptor expression was localized predominantly in alveolar type II and

Yasushi Sakamaki; Kunio Matsumoto; Shinya Mizuno; Shinichiro Miyoshi; Hikaru Matsuda

67

Structural Factorization of Plants to Compute their Functional and Architectural Growth

  Physics Websites

Summary: Structural Factorization of Plants to Compute their Functional and Architectural Growth Courn`ede P simulation of plant growth has been facing a bottleneck due to the cumber- some computation implied by the complex plant topological structure. In this paper, we present a new mathematical model for plant growth

Paris-Sud XI, Université de

68

cells in the presence of insulin, transferrin and fibroflast growth factor (4F medium). This

  Physics Websites

Summary: cells in the presence of insulin, transferrin and fibroflast growth factor (4F medium). This growth precursor cells might be under the control of proteolytic events for their expansion through cell multiplication. In addition to growth hormone (GH) and triiodothyronine (Tg), fetuin, a bovine fetal protein

Paris-Sud XI, Université de

69

Individualbased simulation of the clustering behaviour of epidermal growth factor receptors.

  Computer Technologies and Information Sciences Websites

Summary: with cell growth. We describe the implementation of a program which simulates the stimulation and clustering stimulate within­cell signalling events concerned with cell growth. Thus the cell can communicate in three ways. Firstly a mutation can cause the cell to generate its own growth factor, generating

Kent, University of

70

Controlled delivery of platelet-rich plasma-derived growth factors for bone formation

  Engineering Websites

Summary: Controlled delivery of platelet-rich plasma-derived growth factors for bone formation Helen H. Lu,1.interscience.wiley.com). DOI: 10.1002/jbm.a.31740 Abstract: Platelet-rich plasma (PRP) represents an autolo- gous source of PRP-derived growth factors using a hydrogel carrier system. Specifically, the release of platelet

Lu, Helen H.

71

Modelling and Asymptotic Stability of a Growth Factor-Dependent Stem Cells

  Mathematics Websites

Summary: Modelling and Asymptotic Stability of a Growth Factor-Dependent Stem Cells Dynamics Model) Abstract Under the action of growth factors, proliferating and nonproliferating hematopoietic stem cells population. We propose a mathe- matical model describing the evolution of a hematopoietic stem cell

Crauste, Fabien

72

Thick collagen-based matrices including growth factors to induce 3D neural differentiation

  Physics Websites

Summary: of the substrate, topological and chemical cues like growth factor concentration, orient the cell faith1 Thick collagen-based matrices including growth factors to induce 3D neural differentiation Marie at the crossroad of cell biology and materials science. The present work describes the design and functionalization

Paris-Sud XI, Université de

73

Keratinocyte growth factor signalling: a mathematical model of dermalepidermal interaction in epidermal wound healing

  Environmental Sciences and Ecology Websites

Summary: Keratinocyte growth factor signalling: a mathematical model of dermal±epidermal interaction; received in revised form 11 January 2000; accepted 11 January 2000 Abstract A wealth of growth factors are known to regulate the various cell functions involved in the repair process. An understanding

Rohani, Pejman

74

Role of Transforming Growth Factor in Long-Term Synaptic Facilitation in Aplysia

  Biology and Medicine Websites

Summary: Role of Transforming Growth Factor­ in Long-Term Synaptic Facilitation in Aplysia Fan Zhang, Shogo Endo, Leonard J. Cleary, Arnold Eskin, John H. Byrne* The role of transforming growth factor­ ( TGF- ) in long-term synaptic facilitation was examined in isolated Aplysia ganglia. Treatment with TGF- 1 induced

Byrne, John H.

75

Insulin is a potent myeloma cell growth factor through insulin / IGF-1 hybrid receptor activation

  Physics Websites

Summary: 1 Insulin is a potent myeloma cell growth factor through insulin / IGF-1 hybrid receptor activation; Running title: Insulin is a growth factor for human multiple myeloma cells Key words: multiple myeloma, insulin, IGF-1, IGF-1R, INSR, insulin/IGF-1 hybrid receptor Corresponding Author: Prof. Bernard Klein

Paris-Sud XI, Université de

76

Smoothed Analysis of the Condition Numbers and Growth Factors of Matrices

  Computer Technologies and Information Sciences Websites

Summary: Smoothed Analysis of the Condition Numbers and Growth Factors of Matrices Arvind Sankar Department University Shang-Hua Teng Department of Computer Science Boston University and Akamai Technologies Inc of arbitrary matrices are unlikely to have large condition numbers or large growth factors under Gaussian

Spielman, Daniel A.

77

RELATIONSHIP OF A NEW GROWTH FACTOR REQUIRED BY CERTAIN HEMOLYTIC STREPTOCOCCI TO GROWTH PHENOMENA IN OTHER BACTERIA

  CiteSeer

Summary: In 1941 the discovery of a new growth factor required by certain hemolytic streptococci was described in this laboratory (1). Grossowicz (2) shortly afterward was able to confirm the existence of this substance. Since that time new growth factors, distinct from the known vitamins, have been shown to stimulate growth of several types of bacteria. Pollack and Lindner (3) showed that a substance present in peptone was necessary for growth of Lactobacillus casei during the early part of the incubation period, but was not essential for growth during prolonged incubation. Smith (4) showed that certain strains of Streptococcus lactis were made to grow better by a substance in yeast and in peptone. Kuiken et al. (5) observed an unknown substance in tomato juice which was needed for maximal growth of Lactobacillus arabinosus. Chattaway et al. (6) recognized a growth-promoting substance for the diphtheria bacillus, and Thompson (7) showed that certain propionic acid bacteria were unable to grow satisfactorily unless an unknown material derived from natural products was supplied. Furthermore, it was observed some years ago in the course of the work on the factor


1944-01-01

78

Archimedean L-factors and Topological Field Theories II

  HEP - Theory (arXiv)

Summary: In the first part of this series of papers we propose a functional integral representation for local Archimedean L-factors given by products of the Gamma-functions. In particular we derive a representation of the Gamma-function as a properly regularized equivariant symplectic volume of an infinite-dimensional space. The corresponding functional integral arises in the description of a type A equivariant topological linear sigma model on a disk. In this paper we provide a functional integral representation of the Archimedean L-factors in terms of a type B topological sigma model on a disk. This representation leads naturally to the classical Euler integral representation of the Gamma-functions. These two integral representations of L-factors in terms of A and B topological sigma models are related by a mirror map. The mirror symmetry in our setting should be considered as a local Archimedean Langlands correspondence between two constructions of local Archimedean L-factors.

Anton Gerasimov; Dimitri Lebedev; Sergey Oblezin
2009-12-06

79

Archimedean L-factors and Topological Field Theories II

  CERN Preprints

Summary: In the first part of this series of papers we propose a functional integral representation for local Archimedean L-factors given by products of the Gamma-functions. In particular we derive a representation of the Gamma-function as a properly regularized equivariant symplectic volume of an infinite-dimensional space. The corresponding functional integral arises in the description of a type A equivariant topological linear sigma model on a disk. In this paper we provide a functional integral representation of the Archimedean L-factors in terms of a type B topological sigma model on a disk. This representation leads naturally to a classical Euler integral representation of Gamma-functions. These two integral representations of L-factors in terms of A and B topological sigma models are related by a mirror map. The mirror symmetry in our setting should be considered as a local Archimedean Langlands correspondence between two constructions of local Archimedean L-factors.

Gerasimov, Anton; Oblezin, Sergey
2009-01-01

80

Host factor regulation of Toxoplasma gondii growth and differentiation

  University of California eScholarship Repository

Summary: test specific effects of parasite upon host, and host uponeffect of the supernatant on parasite growth was specific to the parasites, or if hostthe parasite as a tachyzoite without an effect on host cell

Weilhammer, Dina
2010-01-01

81

Matrix Factorizations and Representations of Quivers II: type ADE case

  HEP - Theory (arXiv)

Summary: We study a triangulated category of graded matrix factorizations for a polynomial of type ADE. We show that it is equivalent to the derived category of finitely generated modules over the path algebra of the corresponding Dynkin quiver. Also, we discuss a special stability condition for the triangulated category in the sense of T. Bridgeland, which is naturally defined by the grading.

Hiroshige Kajiura; Kyoji Saito; Atsushi Takahashi
2006-04-03

82

Appendix II. Calculation of Slope Factors for Naturally Occurring Radionuclides

  Environmental Sciences and Ecology Websites

Summary: radioactive decay seriesnatural uranium, Ra-226, and Th-232used in the present report include-life of 5.75 y, and Th-228, with a half-life of 1.91 y. Since the naturally-occurring thorium at the uranium of the slope factors for Th-232, Ra-228+D, and Th-228+D that are listed in the HEAST tables. Natural uranium


83

Insulin-like Growth Factor 2 Is Required for Progression to Advanced Medulloblastoma in patched1 Heterozygous Mice

  Biotechnology Websites

Summary: Insulin-like Growth Factor 2 Is Required for Progression to Advanced Medulloblastoma in patched1. It was previously shown that the loss of function of insulin-like growth factor 2 (igf2) suppresses MB formation

Quake, Stephen R.

84

Charge Form Factors of Quark-Model Pions II

  CERN Preprints

Summary: Experimental data of the pion charge form factor are well represented by Poincar\\'e invariant constituent-quark phenomenology depending on two parameters, a confinement scale and an effective constituent--quark mass. Pion states are represented by eigenfunctions of mass and spin operators and of the light-front momenta. An effective current density is generated by the dynamics from a null-plane impulse current density. A simple shape of the wave function depending only on the confinement scale is sufficient.

Coester, F
2004-01-01

85

Charge Form Factors of Quark-Model Pions II

  Nuclear Theory (arXiv)

Summary: Experimental data of the pion charge form factor are well represented by Poincar\\'e invariant constituent-quark phenomenology depending on two parameters, a confinement scale and an effective constituent--quark mass. Pion states are represented by eigenfunctions of mass and spin operators and of the light-front momenta. An effective current density is generated by the dynamics from a null-plane impulse current density. A simple shape of the wave function depending only on the confinement scale is sufficient.

F. Coester; W. N. Polyzou
2004-09-20

86

Regulation of Growth Anisotropy in Well-Watered and Water-Stressed Maize Roots. II. Role of Cortical Microtubules

  Environmental Sciences and Ecology Websites

Summary: Regulation of Growth Anisotropy in Well-Watered and Water-Stressed Maize Roots. II. Role of alignment of cortical microtubules or cellulose microfibrils. Previously, for the primary root of maize (Zea

Baskin, Tobias

87

An inhibitor of the EGF receptor family blocks myeloma cell growth factor activity of HB-EGF and potentiates

  Physics Websites

Summary: 1 An inhibitor of the EGF receptor family blocks myeloma cell growth factor activity of HB previously found that some myeloma cell lines express the heparin-binding epidermal growth factor-like growth growth. The HB-EGF gene was expressed by bone marrow mononuclear cells of 8/8 patients with myeloma

Paris-Sud XI, Université de

88

Cholesterol Depletion Results in Site-specific Increases in Epidermal Growth Factor Receptor Phosphorylation due to

  Biology and Medicine Websites

Summary: Cholesterol Depletion Results in Site-specific Increases in Epidermal Growth Factor Receptor Phosphorylation due to Membrane Level Effects STUDIES WITH CHOLESTEROL ENANTIOMERS* Received for publication Institute, University of Minnesota, Austin, Minnesota 55912 In A431 cells, depletion of cholesterol

Pike, Linda J.

89

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

  Chemistry Websites

Summary: , downstream of growth factors4,5 , and eIF2 controls loading of the ternary complex on the 40S sub- unit birth. At three months of age, heterozygous mice, independently from gender and genetic background

Cai, Long

90

Novel recombinant protein constructs for improved insulin-like growth factor-1 delivery

  MIT - DSpace

Summary: Four novel recombinant protein constructs were designed to improve the delivery of insulin-like growth factor-1 (IGF-1). The IGF-1 sequence was subcloned into a HisMax plasmid and expressed at low levels by transient ...

Was, Adam (Adam S.)
2006-01-01

91

Role of fibroblast growth factor signalling on the regulation of embryonic stem cells 

  Edinburgh, University of - Research Archive

Summary: Fibroblast growth factor (FGF) signalling plays many fundamentally important roles during the development of the mammalian embryo. However, its effects on pluripotent stem cells derived from mouse and human embryos appear ...

Freile Vinuela, Paz
2008-01-01

92

Effects of cellular and tissue pharmacokinetics on control released growth factors

  MIT - DSpace

Summary: Aim: To examine the effects of cellular and tissue pharmacokinetics on control released growth factors. Motivation: The resurgence of interest in controlled drug delivery reflects the increasing appreciation of the importance ...

Wu, David, 1973-
2001-01-01

93

IGF-1 is the major growth factor on myeloma Blood. Author manuscript

  Physics Websites

Summary: ; HGF ; growth factor Introduction Multiple myeloma (MM) is a clonal plasma-cell disorder. Multiple myeloma cells (MMC) from almost all patients harbor chromosomal abnormalities by FISH , and aberrant gene

Paris-Sud XI, Université de

94

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

  MIT - DSpace

Summary: The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells ...

Sengupta, Shomit

95

Tradeoffs between Stretch Factor and Load Balancing Ratio in Routing on Growth Restricted Graphs

  Computer Technologies and Information Sciences Websites

Summary: Tradeoffs between Stretch Factor and Load Balancing Ratio in Routing on Growth Restricted Graphs the lengths of the routing paths, and the load balancing ratio, which measures how evenly the traffic load bal- ancing ratio is bounded by O((n/c)1-1/k ), where k is the graph's growth rate. We illustrate

Gao, Jie

96

Factors affecting the direction of growth of tree roots M.P. Coutts

  Physics Websites

Summary: Factors affecting the direction of growth of tree roots M.P. Coutts Forestry Commission, Northern of the main roots of a tree is an important determinant of the form of the root system. It affects the way and for cultivation systems which can influence tree growth and anchorage. This review discusses the way in which root

Paris-Sud XI, Université de

97

Somatomdine C/ insulin-like growth factor I (SMC/IGF-I) et rythropose in vitro

  Computer Technologies and Information Sciences Websites

Summary: /insulin-like growth factorI (SM-C/IGF-I) and human growth hormone (hGH) on colony formation by erythroid precursor cells (CFU- E and BFU-E) from children's bone marrow or blood was studied by methylcellulose cloning influencé par de nombreuses hormones, en particulier les stéroïdes 5 (3 (11, les hormones thyroï- diennes ou

Boyer, Edmond

98

Gene expression profile of cytokine and growth factor during differentiation of bone marrow-derived mesenchymal stem cell

  Biology and Medicine Websites

Summary: -renewal and differentiation of hematopoietic stem cells (HSCs) due to MSCs' secretion of cytokines and growth factors cell types, including osteoblasts, adipocytes and endothelial cells. Cytokine and growth factor genes and their derivatives for cell therapy. Ó 2005 Elsevier Ltd. All rights reserved. Keywords: Cytokines; Growth factors

Abraham, Nader G.

99

A Numerical Study of Pulsatile Flow Through a Hollow Fiber Cartridge: Growth Factor-Receptor Binding and Dissociation Analysis

  Computer Technologies and Information Sciences Websites

Summary: of a bioreactor. The multi-physics of fluid flow, the kinetics of fibroblast growth factor (FGF-2) binding to its of fibroblast growth factor-2 (FGF-2) to its cell surface receptor (FGFR) and the role of heparan sulfateA Numerical Study of Pulsatile Flow Through a Hollow Fiber Cartridge: Growth Factor

Zhang, Jun

100

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

  Biology and Medicine Websites

Summary: of cell growth and cell cycle progression Diane C Fingar1,2 and John Blenis*,1 1 Department of Cell-0678, USA Cell growth (an increase in cell mass and size through macromolecular biosynthesis) and cell cycle nutrients (amino acids and energy) and growth factors (in higher eukaryotes) to regulate cell growth


101

Dust origin in late-type dwarf galaxies: ISM growth vs. type II supernovae

  CERN Preprints

Summary: We re-evaluate the roles of different dust sources in dust production as a function of metallicity in late-type dwarf galaxies, with the goal of understanding the relation between dust content and metallicity. The dust content ol late-type dwarf galaxies with episodic star formation is studied with a multicomponent model of dust evolution, which includes dust input from AGB stars, type II SNe and dust growth by accretion of atoms in the ISM. Dust growth in the ISM becomes an important dust source in dwarf galaxies, on the timescale of 0.1 - a few Gyrs. It increases the dust-to-gas ratio (DGR) during post-burst evolution, unlike type II SNe, which eject grains to the ISM only during starbursts. Before the dust growth in the ISM overtakes the dust production, AGB stars can be major sources of dust in metal-poor dwarf galaxies. Our models reproduce the relation between the DGR and oxygen abundance, derived from observations of a large sample of dwarf galaxies. The steep decrease in the DGR at low O values is exp...

Zhukovska, Svitlana
2014-01-01

102

Growth hormones. II. Structure—function relationships N. Chne J. Martal P. de la Llosa J. Charrier

  Physics Websites

Summary: Review Growth hormones. II. Structure—function relationships N. Chêne J. Martal P. de la-en-Josas, France; 2 Laboratoire des Hormones polypeptidiques, CNRS, 91118 Gif sur-Yvette, France; 3 Station de-9-1988) Summary ― Localization of the somatotropic activity of growth hormones from several species

Paris-Sud XI, Université de

103

INFLUENCE OF VOCALIC CONTEXT ON PERCEPTION OF THE [J [s] DISTINCTION: II. SPECTRAL FACTORS

  Multidisciplinary Databases and Resources Websites

Summary: . Repp and Virginia A. Mann Abstract. The posi tion of the category boundary along a synthetic [J J-[ sJ), listeners perceive more instances of [sJ in the context of [u] than in the context of [a] (KunisakiINFLUENCE OF VOCALIC CONTEXT ON PERCEPTION OF THE [J [s] DISTINCTION: II. SPECTRAL FACTORS Bruno H


104

The growth factor of matter perturbations in an f(R) gravity

  General Relativity & Quantum Cosmology (arXiv)

Summary: The growth of matter perturbations in the $f(R)$ model proposed by Starobinsky is studied in this paper. Three different parametric forms of the growth index are considered respectively and constraints on the model are obtained at both the $1\\sigma$ and $2\\sigma$ confidence levels, by using the current observational data for the growth factor. It is found, for all the three parametric forms of the growth index examined, that the Starobinsky model is consistent with the observations only at the $2\\sigma$ confidence level.

Xiangyun Fu; Puxun Wu; Hongwei Yu
2010-12-10

105

Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon

  Biology and Medicine Websites

Summary: factor-I/II bioavail- ability and mitogenic activity. Analysis of the proximal pro- moter of the hIGFBP-1 physiological processes. The hAhR, a ligand-activated transcription factor, is pri- marily classified/II/III enzymes (Ramadoss et al., 2005). The hAhR adheres to the classical ligand-activated transcription factor

Perdew, Gary

106

Further fractionation studies on unidentified growth factors in distillers dried solubles

  Texas A&M University - TxSpace

Summary: of at least one of the uni entified factors. Novak, Hau. e and Carrick ('47) reported that di. stillers dried soluoles c~ntained an unidentified chick growth factor not identical with snf of the then known B vitamins. Novak and Hauge ('48) announced...

Rozacky, Eugene Emil
1955-01-01

107

Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats

  Biology and Medicine Websites

Summary: Beneficial Effects of Hematopoietic Growth Factor Therapy in Chronic Ischemic Stroke in Rats Li. Vania Apkarian, PhD; John A. Kessler, MD Background and Purpose--Stroke is the leading cause of adult disability worldwide. Currently, there is no effective treatment for stroke survivors. Stem cell factor (SCF

Apkarian, A. Vania

108

Trade-offs between Stretch Factor and Load Balancing Ratio in Routing on Growth Restricted

  Computer Technologies and Information Sciences Websites

Summary: 1 Trade-offs between Stretch Factor and Load Balancing Ratio in Routing on Growth Restricted Graphs of the routing paths, and the load balancing ratio, which measures the evenness of the traffic distribution. We show that if the routing algorithm is required to use paths with stretch factor c, then its load

Gao, Jie

109

NEURON SURVIVAL, AXON GROWTH AND THE TRANSCRIPTION FACTOR SRY-BOX CONTAINING GENE 11 (SOX11)

  Biology and Medicine Websites

Summary: of Pittsburgh, 2006 #12;v increased, suggesting Sox11 was important for expression of genes involved in Neuro2ANEURON SURVIVAL, AXON GROWTH AND THE TRANSCRIPTION FACTOR SRY-BOX CONTAINING GENE 11 (SOX11 is trophic factor sensitive and that it may contribute to the transcriptional control of genes involved

Sibille, Etienne

110

that of mice lacking components of the hepa-tocyte growth factor/Met signaling pathway

  Biology and Medicine Websites

Summary: that of mice lacking components of the hepa- tocyte growth factor/Met signaling pathway (25, 26 be the consequence of a constantly reduced supply of trophic factors (such as NGF) caused by impaired dynein of ALS (29). Retrograde transport of NFs is dynein-dependent, suggesting that the buildup of NFs

Zhou, Yi-Feng

111

Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to

  Physics Websites

Summary: used as single agents to treat cancers. They decrease tumor cell expression of hypoxia-inducible factor 1-a (HIF-1a) and vascular endothelial growth factor (VEGF). Hypothesizing that this might normalize/Principal Findings: Erlotinib treatment of human tumor cells in vitro and mice bearing xenografts in vivo led

Yodh, Arjun G.

112

The epidermal growth factor receptor as a target for therapy in breast carcinoma. Breast Cancer Res

  CiteSeer

Summary: Epidermal growth factor (EGF) receptors are expressed at high levels in about one third of epithelial cancers, and autocrine activation of EGF receptors appears to be critical for the growth of many tumors. We hypothesized that blockade of the binding sites for EGF and transforming growth factor-? on EGF receptors with an antireceptor monoclonal antibody (mAb) might be an effective anti-cancer therapy. We produced murine mAb 225against EGF receptors and demonstrated blockade of receptor function, as well as inhibition of cell growth in cultures and in nude mouse xenografts. mAb C225is the human:murine chimeric version of mAb 225. Cell cycle inhibition occurred in G1 phase, and was due to upregulation of p27Kip1, resulting in inhibition of cyclin E/cyclin dependent kinase-2 activity and hypophosphorylation of Rb. In addition, the amount and/or activities of a number of proapoptotic molecules were enhanced. The antitumor activity in vivo against xenografts was at least partly attributable to reduced vascularization, resulting from decreased vascular endothelial growth factor and basic fibroblast growth factor production by the tumor cells. Metastasis of xenografts was curtailed with mAB C225treatment, accompanied by a decrease in tumor production of MMP-9. Further studies showed that mAbs 225and C225enhanced the cytotoxicity of chemotherapy against xenografts of a

J Mendelsohn
1994-01-01

113

Baroclinic Vorticity Production in Protoplanetary Disks; Part II: Vortex Growth and Longevity

  CERN Preprints

Summary: The factors affecting vortex growth in convectively stable protoplanetary disks are explored using numerical simulations of a two-dimensional anelastic-gas model which includes baroclinic vorticity production and radiative cooling. The baroclinic feedback, where anomalous temperature gradients produce vorticity through the baroclinic term and vortices then reinforce these temperature gradients, is found to be an important process in the rate of growth of vortices in the disk. Factors which strengthen the baroclinic feedback include fast radiative cooling, high thermal diffusion, and large radial temperature gradients in the background temperature. When the baroclinic feedback is sufficiently strong, anticyclonic vortices form from initial random perturbations and maintain their strength for the duration of the simulation, for over 600 orbital periods. Based on both simulations and a simple vortex model, we find that the local angular momentum transport due to a single vortex may be inward or outward, dependin...

Petersen, M R; Julien, K; Petersen, Mark R.; Stewart, Glen R.; Julien, Keith
2006-01-01

114

Properly Oriented Heparin-Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth Factor,

  Chemistry Websites

Summary: to cell growth and differentiation (Baird & Bohlen, 1990; Basilico & Moscatelli, 1992; Folkman & Klagsbrun Fibroblast Growth Factor, Franklin J. Moy,§ Michal Safran,| Andrew P. Seddon,,# Doug Kitchen,§ Peter Bo: Interaction of basic fibroblast growth factor (FGF-2) with heparin or heparan sulfate proteoglycans (HSPGs

Powers, Robert

115

RNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes

  Biology and Medicine Websites

Summary: -transcriptional recruitment of pre-mRNA processing factors to human genes. Capping factors associate with paused RNARNA polymerase II pauses and associates with pre-mRNA processing factors at both ends of genes Kira genes and accumulate with paused polymerase in the 3¢ flanking region. The 3¢ processing factors


116

Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5

  CiteSeer

Summary: We investigated the role of keratinocyte growth factor (KGF) in regulation of alveolar epithelial cell (AEC) phenotype in vitro. Effects of KGF on cell morphology, expression of surfactant apoproteins A, B, and C (SP-A,-B, and-C), and expression of aquaporin 5 (AQP5), a water channel present in situ on the apical surface of alveolar type I (AT1) cells but not expressed in alveolar type II (AT2) cells, were evaluated in AECs grown in primary culture. Observations were made on AEC monolayers grown in serum-free medium without KGF (control) or grown continuously in the presence of KGF (10 ng/ml) from either Day 0 (i.e., the time of plating) or Day 4 or 6 through Day 8 in culture. AECs monolayers express AQP5 only on their apical surfaces as determined by cell surface biotinylation studies. Control AECs grown in the absence of KGF through Day 8 express increasing levels of AQP5, consistent with transition toward the AT1 cell phenotype. Exposure of AECs to KGF from Day 0 results in decreased AQP5 expression, retention of a cuboidal morphology, and greater numbers of lamellar bodies relative to control on Day 8 in culture. AECs treated with KGF from Day 4 or 6 exhibit a decrease in AQP5 expression through subsequent days in culture, as well as an increase in expression of surfactant apoproteins. These data, showing that KGF both prevents and reverses the increase in AQP5 (and decrease in surfactant apoprotein) expression that accompanies progression of the AT2 toward the AT1 cell phenotype, support the concepts that

Zea Borok; Richard L. Lubman; Spencer I. Danto; Xiao-ling Zhang; Stephanie M. Zabski; On S. King; Douglas M. Lee; Peter Agre; Edward D. Cr
1998-01-01

117

Unidentified growth factors in the diet of chicks reared under commercial broiler production conditions

  Texas A&M University - TxSpace

Summary: sources of unidentified chick growth factors to promote growth of chicks reared under practical broiler conditions . ? . , , ....... ? 50 Investigations concerning xhe affect of con? densed fish solubles s dried whey., an antibiotic fermentation... to be re^uir^d by the chick?*. Many investigators are of the opin? ion that such substances are present in condensed fish solubles, whale solubles, fish meal, hydrolyzed whey, dried skim milk, dried brewers' yeast, and other types of yeast, distillers...

Camp, Arthur A.
1958-01-01

118

Fibroblast growth factor-specific modulation of cellular response by syndecan-4

  CiteSeer

Summary: roteoglycans participate in growth factor interaction with the cell surface through their heparan sulfate chains (HS), but it is not known if they are otherwise involved in growth factor signaling. It appears now that the syndecan-4 core protein, a transmembrane proteoglycan shown previously to bind phosphatidylinositol 4,5-bisphosphate (PIP2) and activate PKC?, participates in mediating the effects of fibroblast growth factor (FGF)2 on cell function. Mutations in the cytoplasmic tail of syndecan-4 that either reduced its affinity to PIP2 (PIP2 ? ) or disrupted its postsynaptic density 95, disk large, zona occludens-1 (PDZ)-dependent binding (PDZ ? P) produced a FGF2-specific dominant negative phenotype in endothelial cells as evi-

Arie Horowitz; Eugene Tkachenko; Michael Simons
2002-01-01

119

Growth of a Vortex Mode during Gravitational Collapse Resulting in Type II Supernova

  Astrophysics (arXiv)

Summary: We investigate stability of a gravitationally collapsing iron core against non-spherical perturbation. The gravitationally collapsing iron core is approximated by a similarity solution for dynamically collapsing polytropic gas sphere. We find that the similarity solution is unstable against non-spherical perturbations. The perturbation grows in proportion to $ (t - t_0) ^{-\\sigma} $ while the the central density increases in proportion to $ (t - t_0) ^{-2} $. The growth rate is $ \\sigma = 1/3 + \\ell (\\gamma - 4/3) $, where $ \\gamma $ and $ \\ell $ denote the polytropic index and the parameter $ \\ell $ of the spherical harmonics, $ Y_{\\ell} ^m (\\theta, \\phi) $, respectively. The growing perturbation is dominated by vortex motion. Thus it excites global convection during the collapse and may contribute to material mixing in a type II supernova.

Tomoyuki Hanawa; Tomoaki Matsumoto
2000-01-26

120

Mon. Not. R. Astron. Soc. 322, 419425 (2001) Formulae for growth factors in expanding universes containing matter

  Physics Websites

Summary: , the growth factor evolves as ga 5Vm 2 Ha a a 0 daH aH3HaH3 5Vmaa2 Ha3 2 a 0 daH aH3HaH3 ; where Vma Vma23, for the growth factor g (hMon. Not. R. Astron. Soc. 322, 419±425 (2001) Formulae for growth factors in expanding universes

Weijgaert, Rien van de
2001-01-01

121

Draft: 3/12/2009 142:225 Growth Factor Receptor Signaling

  Biotechnology Websites

Summary: in disease (vascular diseases, cancer) d. -Catenin signaling (Wnt proteins) · Mediator of development production o TGF-/Wnt and ligand gradients during development · Cooperation/antagonism between transcription the angiogenic switch o VEGF/VEGF-targeted therapeutics c. FGF and HGF family of growth factors · Signaling


122

INFUSION OF NERVE GROWTH FACTOR (NGF) INTO KITTEN VISUAL CORTEX INCREASES IMMUNOREACTIVITY FOR NGF, NGF

  Biology and Medicine Websites

Summary: PLASTICITY OR COLUMN DEVELOPMENT M. A. SILVER, M. FAGIOLINI, D. C. GILLESPIE, C. L. HOWE, M. G. FRANK, N. P administration of nerve growth factor (NGF) has been shown to block or attenuate visual cortical plasticity in the rat. In cats and ferrets, the e¡ects of exogenous NGF on development and plasticity of visual cortex

Issa, Naoum

123

Nanosize effect on the hygroscopic growth factor of aerosol particles G. Biskos,1

  Environmental Sciences and Ecology Websites

Summary: mobility diameters of 6 to 60 nm were measured using a tandem nano-Differential Mobility AnalyzerNanosize effect on the hygroscopic growth factor of aerosol particles G. Biskos,1 L. M. Russell,2 P impurities. Citation: Biskos, G., L. M. Russell, P. R. Buseck, and S. T. Martin (2006), Nanosize effect

Russell, Lynn

124

Factors influencing the growth of intensively reared kids from birth to twelve weeks of age

  Computer Technologies and Information Sciences Websites

Summary: Factors influencing the growth of intensively reared kids from birth to twelve weeks of age H-week weight. There were no interactions influencing the birth weight of kids. However, the 12-week interactions. Loss of kids between years was significantly (P

Boyer, Edmond

125

Cytokine & Growth Factor Reviews 12 (2001) 245257 Molecular piracy of Kaposi's sarcoma associated herpesvirus

  Biology and Medicine Websites

Summary: Cytokine & Growth Factor Reviews 12 (2001) 245­257 Survey Molecular piracy of Kaposi's sarcoma6ard medical school, 1 Pine Hill Dri6e, Southborough, MA 01772, USA Abstract Kaposi's Sarcoma with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and Multicentric Casttleman's disease. KSHV

Damania, Blossom
2001-01-01

126

Hepatic differentiation of human embryonic stem cells on growth factor-containing surfaces

  Biotechnology Websites

Summary: Hepatic differentiation of human embryonic stem cells on growth factor-containing surfaces Mahboobe molecules to form 500 mm diameter spots. hESCs were cultured onto these GF-containing ECM spots for up to 12. Stem cells cultured on GF-containing surfaces stained positive for the endoderm markers SOX17 and FOXA2

Revzin, Alexander

127

Pulmonary effects of keratinocyte growth factor in newborn rats exposed to hyperoxia

  Physics Websites

Summary: -00411629,version1-28Aug2010 Author manuscript, published in "AJP - Lung Cellular and Molecular Physiology 2009;297(5):L965-76" DOI : 10.1152/ajplung.00136.2009 #12;2 Abstract. Acute lung injury and compromised of keratinocyte growth factor (KGF), a cell-cell mediator with pleiotrophic lung effects, are associated with low

Paris-Sud XI, Université de

128

Chlamydia muridarum Evades Growth Restriction by the IFN--Inducible Host Resistance Factor Irgb101

  Biology and Medicine Websites

Summary: Chlamydia muridarum Evades Growth Restriction by the IFN- -Inducible Host Resistance Factor Irgb101. Taylor,§¶ William F. Dietrich, and Michael N. Starnbach2 * Chlamydiae are obligate intracellular Chlamydia species have been linked to host variations in IFN- -mediated immune responses. In mouse cells

Starnbach, Michael

129

The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor

  Biotechnology Websites

Summary: target cells is an effective approach to overcome the shortcomings of protein delivery of growth factors proteins [3]. Major barriers with protein therapy are cost, low bioavailability and supraphysiological dosage for therapeutic efficacy [4]. One strategy to overcome these draw- backs is gene therapy [5

Salem, Aliasger K.

130

Human corneal epithelial cell response to epidermal growth factor tethered via coiled-coil interactions

  Materials Science Websites

Summary: Polytechnique de Montréal, P.O. Box 6079, succ. Centre-Ville, Montréal (Qc), Canada H3C 3A7 c Animal Cell growth factor (EGF) on polyethylene terephthalate (PET) films. After amination of PET surfaces by ammonia-[30-(2-pyridyldithio)-propionamido] hexanoate (LC-SPDP) linker, and the Kcoil-functionalized films were characterized

Buschmann, Michael

131

Growth Factor and Bcl-2 Mediated Survival During Abortive Proliferation of

  Biology and Medicine Websites

Summary: Growth Factor and Bcl-2 Mediated Survival During Abortive Proliferation of Hybridoma Cell Line John-1606, specifically with respect to the pos- sible environmental causes, and the ability of overex- pressed human bcl-2 (hbcl-2) to mitigate cell death. Abortive proliferation, or continuous proliferation

Sinskey, Anthony J.

132

Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle

  Engineering Websites

Summary: Members of the vascular endothelial growth factor (VEGF) family of proteins are critical regulators on experimental measurements, the model includes: VEGF secretion from muscle fibers; binding to the extracellular in resting skeletal muscle with uniform VEGF secretion, due to non-uniform capillary distribution

Popel, Aleksander S.

133

Immobilization of Growth Factors on Collagen Scaffolds Mediated by Polyanionic Collagen Mimetic Peptides and Its

  Biology and Medicine Websites

Summary: mimetic peptide (CMP) architecture consisting of multiple anionic charges at the peptide's N and differentiation of cells in collagen scaffolds by localization and sustained delivery of growth factors and other constraint can severely limit the size and architecture of 3-D cellular constructs, resulting in an urgent

Chen, Christopher S.

134

Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis

  Biology and Medicine Websites

Summary: Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis) is an endothelial cell-specific angiogenic protein suspected to be involved in the pathogenesis of endometriosis between the SNPs in the VEGF region and endometriosis. To further investigate the reported association

Nyholt, Dale R.

135

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

  CiteSeer

Summary: Abstract. The dissociation, migration, and remodeling of epithelial monolayers induced by hepatocyte growth factor (HGF) entail modifications in cell adhesion and in the actin cytoskeleton through unknown mechanisms. Here we report that ezrin, a membrane–cytoskeleton linker, is crucial to HGF

Tiziana Crepaldi; Alexis Gautreau; Paolo M. Comoglio; Daniel Louvard; Monique Arpin
1997-01-01

136

Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search-Projection

  Biotechnology Websites

Summary: Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search kinase (PTK) is an important protein target for anti-tumor drug discovery. To identify potential EGFR inhibitors, we conducted a quantitative structure­activity relationship (QSAR) study on the inhibitory

Zhang, Yang

137

Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs

  Biology and Medicine Websites

Summary: B) family of receptor tyrosine kinases plays an important role in regulating normal and oncogenic cellular physiology. While structures of isolated EGFR extracellular domains and intracellular protein tyrosine kinase domains have suggested mechanisms for growth factor-mediated receptor dimerization and allosteric kinase

Springer, Timothy A.

138

-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-1Induced Myofibroblast Differentiation of

  Engineering Websites

Summary: -Catenin Mediates Mechanically Regulated, Transforming Growth Factor- 1­Induced Myofibroblast Differentiation of Aortic Valve Interstitial Cells Jan-Hung Chen, Wen Li Kelly Chen, Krista L. Sider, Cindy Ying Yin Yip, Craig A. Simmons Objective--In calcific aortic valve disease, myofibroblasts and activation

Simmons, Craig A.

139

Fibroblast growth factor (FGF) signalling has been implicated during several phases of early embryogenesis, including the

  Biology and Medicine Websites

Summary: of several cell lineages and the coordination of morphogenetic movements. Here, we summarise our current at the surface of the cells. It considerably increases the affinity of FGF ligands for their receptors. Inner: Fibroblast growth factor, Embryogenesis, Mesoderm, Morphogenesis, Patterning, Stem cells Introduction

Amaya, Enrique

140

FACTORS CONTROLLING GROWTH AND SURVIVAL OF CULTURED SPOT PRAWN, PANDALUS PLATYCEROS,

  Environmental Sciences and Ecology Websites

Summary: FACTORS CONTROLLING GROWTH AND SURVIVAL OF CULTURED SPOT PRAWN, PANDALUS PLATYCEROS, IN PUGET SOUND ofjuvenile and yearling spot prawns, Pandalus platyceros, were studied at two sites in Puget Sound-free water. Although the cooler central Puget Sound site was judged suitable for prawn culture, fluctuations


141

The Prostate 66:779 ^787 (2006) Vascular Endothelial Growth Factor Productionin

  Biology and Medicine Websites

Summary: The Prostate 66:779 ^787 (2006) Vascular Endothelial Growth Factor Productionin Human Prostate-Lipoxygenase (P12-LOX) expression is associated with advanced stage and grade prostate cancer stimulation of signal transduction in prostate cancer cell lines following exposure to 12(S)-HETE. RESULTS. P

Jankun, Jerzy
2006-01-01

142

Migration Characteristics of Prostate Cancer Cells in Response to Epidermal Growth Factor (EGF)

  Engineering Websites

Summary: Migration Characteristics of Prostate Cancer Cells in Response to Epidermal Growth Factor (EGF) S to the American Cancer Society, prostate cancer is the second most common cause of cancer related death in men prostate cancer, cellular deformation leads to a shift from androgen- dependent to androgen

Chiao, Jung-Chih

143

Cultivating liver cells on printed arrays of hepatocyte growth factor Caroline N. Jones a

  Fission and Nuclear Technologies Websites

Summary: Cultivating liver cells on printed arrays of hepatocyte growth factor Caroline N. Jones a , Nazgul, University of California, Sacramento, CA 95817, USA c Department of Medicine, Transplant Research Institute), a protein important in liver development and regeneration, on microarrays of extracellular matrix (ECM

Revzin, Alexander

144

Local Delivery of Basic Fibroblast Growth Factor (bFGF) Using Adsorbed Silyl-heparin,

  Physics Websites

Summary: Local Delivery of Basic Fibroblast Growth Factor (bFGF) Using Adsorbed Silyl-heparin, Benzyl for binding. Once adsorbed the silyl-heparin/ FGF was able to induce capillary tube formation of endothelial into the extracellular matrix. The binding of FGFs to heparin/HS results in the formation or stabiliza- tion of dimers

Homes, Christopher C.

145

Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and

  Biology and Medicine Websites

Summary: Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus -strands hydrogen bond to each other and their interaction is postulated from both NMR and X-ray structure), hydrogen bond with each other as a pair of antiparallel -strands within the six-stranded -barrel

Blaber, Michael

146

Formulae for Growth Factors In Expanding Universes Containing Matter and a Cosmological Constant

  Astrophysics (arXiv)

Summary: Formulae are presented for the linear growth factor D/a and its logarithmic derivative dlnD/dlna in expanding Friedmann-Robertson-Walker Universes with arbitrary matter and vacuum densities. The formulae permit rapid and stable numerical evaluation. A fortran program is available at http://casa.colorado.edu/~ajsh/growl/ .

A. J. S. Hamilton
2001-01-25

147

Targeting the Dimerization of Epidermal Growth Factor Receptors with Small-Molecule Inhibitors

  Biology and Medicine Websites

Summary: Targeting the Dimerization of Epidermal Growth Factor Receptors with Small-Molecule Inhibitors receptor activation by blocking dimerization with small molecules. While inhibitors of protein / pro- tein-genera- tion lead compound represents the first drug-like, small-molecule inhibitor of EGF receptor activation

Pike, Linda J.

148

Decreased Lung Fibroblast Growth Factor 18 and Elastin in Congenital Diaphragmatic Hernia and Models

  Physics Websites

Summary: Decreased Lung Fibroblast Growth Factor 18 and Elastin in Congenital Diaphragmatic Hernia of treatments. Methods: Human CDH and control lungs were collected post-mortem. Diaphragmatic hernia was created Congenital diaphragmatic hernia (CDH) is a developmental abnormality that is associated with high mortality

Paris-Sud XI, Université de

149

Modelling and Asymptotic Stability of a Growth Factor-Dependent Stem Cells

  Physics Websites

Summary: differentiate and divide, so as to produce blood cells. Growth factors act at different levels, differential equations, distributed delay, asymptotic sta- bility, Lyapunov function, Hopf bifurcation, blood cells committed to one blood cell lin- eage: white cells, red blood cells or platelets) and self

Paris-Sud XI, Université de

150

VEGF121 and VEGF165 Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor

  Biology and Medicine Websites

Summary: VEGF121 and VEGF165 Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor blood vessels are formed from existing vessels in response to angiogenic stimuli (Carmeliet, 2000; Folk also regulates vessel diameter, although this has not been tested explicitly. The two most abundant

Hughes, Christopher C. W.

151

Increased Functional Half-life of Fibroblast Growth Factor-1 by Recovering a Vestigial Disulfide Bond

  Biology and Medicine Websites

Summary: Bond Jihun Lee* and Michael Blaber Abstract: The fibroblast growth factor (FGF) family of proteins, is present as a free cysteine (and adjacent position 66 is a noncysteine residue) (Zhang, et al. 1991, Blaber of point mutations at position 83 and 66 (Lee and Blaber 2009b). Notably, introduction of cysteine

Blaber, Michael

152

Fractionation studies on the unidentified growth factor(s) in distillers dried solubles

  Texas A&M University - TxSpace

Summary: &- " . 11xture; Ai, ("&. +). MLS M~2 Sal CoC12'6LL20e )1 aml +ps $~) Say oor lees (bg4rate4 gluoose), o$ gm, is + w + 1 aixture~ 1 + ~& kb(OR&002)2~%%(C@)2, , 2~1 agL NaF, li+ gaL oora~y 44 /ha ggj@yy kkka4 aa osleiua earboaate (Q8P). ~V154II1$5 L L..., uuL ua, rl 'ded Little bIOlc rICal . XCt iuIiy -mid. tn. it IL 1i 'ht bo . . IeCu 3 lrx 0 uc'(1 E)i vitaxxiIx 8, ( o I' t'' '1' ' rxic ulsu i i r r, xx o, seix tile efxeCt o3 9, ietniullinc, ux. OtiC, XCIu. , 3:xey x, utixr, dif-crex(t, roteixl...

Dannenburg, Warren Nathaniel
1955-01-01

153

Genetic and environmental factors affecting growth and reproduction characters of Morada Nova sheep in Northeastern Brazil

  Texas A&M University - TxSpace

Summary: of Morada Nova sheep. Data were obtained from 1, 338 ewes and 989 lambs sired by 50 rams at the Iracema Farm ? EPACE ? Quixada, Ceaza, Brazil from 1979 to 1984. The growth traits studied were birth weight (BW), weaning weight (WW), and yearling weight... (YW). Environmental factors con- sidered were year and location of birth, age of dam, sex of lamb, and type of birth and rearing. All environmental factors significantly affected (P & . 01) BW, WW and YW. Some factors, such as age of dam, had great...

Fernandes, Antonio Amaury Oria
1985-01-01

154

Role of vascular endothelial growth factor (VEGF) in granulosa cell function: involvement of heterotrimeric G-protein signalling pathways. 

  Edinburgh, University of - Research Archive

Summary: Vascular Endothelial Growth Factor (VEGF) has been shown to be an absolute requirement for ovarian follicle development. Although VEGF is commonly regarded primarily as an angiogenic factor, granulosa cells are a major ...

Doyle, Lynsey Kerr
2009-01-01

155

Factorization of numbers with Gauss sums: II. Suggestions for implementations with chirped laser pulses

  Quantum Physics (arXiv)

Summary: We propose three implementations of the Gauss sum factorization schemes discussed in part I of this series: (i) a two-photon transition in a multi-level ladder system induced by a chirped laser pulse, (ii) a chirped one-photon transition in a two-level atom with a periodically modulated excited state, and (iii) a linearly chirped one-photon transition driven by a sequence of ultrashort pulses. For each of these quantum systems we show that the excitation probability amplitude is given by an appropriate Gauss sum. We provide rules how to encode the number N to be factored in our system and how to identify the factors of N in the fluorescence signal of the excited state.

W. Merkel; S. Wölk; W. P. Schleich; I. Sh. Averbukh; B. Girard; G. G. Paulus
2012-10-24

156

Mixed-mode, high-cycle fatigue-crack growth thresholds in II. Quantication of crack-tip shielding

  Materials Science Websites

Summary: Mixed-mode, high-cycle fatigue-crack growth thresholds in Ti±6Al±4V II. Quanti®cation of crack alloy is examined under high-cycle fatigue loading conditions, i.e., at a loading frequency of 1000 Hz Science Ltd. All rights reserved. Keywords: High-cycle fatigue; Fatigue thresholds; Mixed mode; Crack

Ritchie, Robert

157

Growth, Atomic Structure, and Type-II Band Alignment of GaSb/GaAs Quantum Dots and Rings

  Mathematics Websites

Summary: Growth, Atomic Structure, and Type-II Band Alignment of GaSb/GaAs Quantum Dots and Rings Dähne 1 1/8 of the Deutsche Forschungsgemeinschaft as well as by the European Commission in the SANDiE Network of Excellence-Kirsch, K. Pötschke, U. W. Pohl, D. Bimberg, and M. Dähne, Appl. Phys. Lett. 85, 5890 (2004). ! R. Timm, J

Nabben, Reinhard

158

Baroclinic Vorticity Production in Protoplanetary Disks; Part II: Vortex Growth and Longevity

  Astrophysics (arXiv)

Summary: The factors affecting vortex growth in convectively stable protoplanetary disks are explored using numerical simulations of a two-dimensional anelastic-gas model which includes baroclinic vorticity production and radiative cooling. The baroclinic feedback, where anomalous temperature gradients produce vorticity through the baroclinic term and vortices then reinforce these temperature gradients, is found to be an important process in the rate of growth of vortices in the disk. Factors which strengthen the baroclinic feedback include fast radiative cooling, high thermal diffusion, and large radial temperature gradients in the background temperature. When the baroclinic feedback is sufficiently strong, anticyclonic vortices form from initial random perturbations and maintain their strength for the duration of the simulation, for over 600 orbital periods. Based on both simulations and a simple vortex model, we find that the local angular momentum transport due to a single vortex may be inward or outward, depending its orientation. The global angular momentum transport is highly variable in time, and is sometimes negative and sometimes positive. This result is for an anelastic gas model, and does not include shocks that could affect angular momentum transport in a compressible-gas disk.

Mark R. Petersen; Glen R. Stewart; Keith Julien
2006-12-05

159

MEASUREMENT OF ACCUARACY OF THE ADVANCED PLACEMENT EXAM FOR CALCULUS II AND THE INFLUENTIAL FACTORS TO PRECALCULUS

  Mathematics Websites

Summary: MEASUREMENT OF ACCUARACY OF THE ADVANCED PLACEMENT EXAM FOR CALCULUS II AND THE INFLUENTIAL FACTORS ---------------------------------------------------------------------------------------------- 4 CHAPTERS 1. INTRODUCTION: AP CALCULUS STUDY-------------------------------------------------- 5 2---------------------------------------------------------------------- 9. Probability of AP Calculus Grades

Miles, Will

160

Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells

  CiteSeer

Summary: Abstract. Hepatocyte growth factor/scatter factor (HGF/SF) is the mesenchymal ligand of the epithelial tyrosine kinase receptor c-Met. In vitro, HGF/SF has morphogenic properties, e.g., induces kidney epithelial cells to form branching ducts in collagen gels. Mutation of the HGF/SF gene in mice results in embryonic lethality due to severe liver and placenta defects. Here, we have evaluated the morphogenic activity of HGF/SF with a large variety of epithelial cells grown in threedimensional collagen matrices. We found that HGF/SF induces SW 1222 colon carcinoma cells to form cryptlike structures. In these organoids, cells exhibit apical/ basolateral polarity and build a well-developed brush border towards the lumen. Capan 2 pancreas carcinoma cells, upon addition of HGF/SF, develop large hollow

Volker Brinkmann; Hutan Foroutan; Martin Sachs; K. Michael Weidner; Walter Birchmeier
1995-01-01

161

High-Resolution Solution Structure of Basic Fibroblast Growth Factor Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy

  Chemistry Websites

Summary: Da that exhibits a variety of functions related to cell growth and differentiation, has been determined using three & Moscatelli, 1992; Miya- moto et al., 1993). Its diverse role in regulating cell growth and differentiationHigh-Resolution Solution Structure of Basic Fibroblast Growth Factor Determined by Multidimensional

Powers, Robert

162

[CANCER RESEARCH 62, 8998, January 1, 2002] Growth Factor Requirements and Basal Phenotype of an Immortalized Mammary

  Biology and Medicine Websites

Summary: that are capable of conferring upon the cell an actual growth advantage. Such an advantage may relieve a cell of its normal requirements for a particular growth factor or may enhance the ability of a cell program is executed that exerts control over the progression from cell growth through the acquisition

Brown, Myles

163

Sphingosine and Sphingosine 1-Phosphate Differentially Modulate Platelet-derived Growth Factor-BB-induced Ca2

  Biology and Medicine Websites

Summary: (RTKs) (1, 2). PDGF1 is able to promote growth in fibroblasts (3), smooth muscle cells (4), and glialSphingosine and Sphingosine 1-Phosphate Differentially Modulate Platelet-derived Growth Factor of sphingosine and sphingosine 1-phosphate in Ca2 signaling following platelet-derived growth fac- tor (PDGF

Fatatis, Alessandro

164

89Zr-N-Succinyldesferal-human anti-insulin-like growth factor 1 receptor monoclonal antibody R1507

  Biology and Medicine Websites

Summary: 89Zr-N-Succinyldesferal-human anti-insulin-like growth factor 1 receptor monoclonal antibody R1507 [89Zr-R1507] Kam Leung, PhD National Center for Biotechnology Information, NLM, NIH, Bethesda, MD Chemical name: 89Zr-N-Succinyldesferal-human anti-insulin-like growth factor 1 receptor monoclonal antibody

Levin, Judith G.

165

[125I]-Labeled monoclonal antibody L8A4 against epidermal growth factor receptor variant III (EGFRvIII)

  Biology and Medicine Websites

Summary: [125I]-Labeled monoclonal antibody L8A4 against epidermal growth factor receptor variant III (EGFRv receptor variant III (EGFRvIII) Abbreviated name: [125I]SGMIB-L8A4 Synonym: Agent Category: Monoclonal antibody Target: Epidermal growth factor receptor variant III (EGFRvIII) Target Category: Receptor Method

Levin, Judith G.

166

Differential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding to the p75 Neurotrophin Receptor*

  Biology and Medicine Websites

Summary: and §Cornell University, Medical College, Department of Medicine, Division of Hematology-Oncology, New YorkDifferential Modulation of Neuron Survival during Development by Nerve Growth Factor Binding, New York 10021 Nerve growth factor (NGF) supports the survival and differentiation of distinct

Ibáñez, Carlos

167

Integrin v 3 mediates platelet-derived growth factor-BB-stimulated collagen gel contraction in cells expressing signaling

  Biology and Medicine Websites

Summary: Integrin v 3 mediates platelet-derived growth factor-BB-stimulated collagen gel contraction in cells expressing signaling deficient integrin 2 1 Gunilla Grundstro¨m,a Deane F. Mosher,b Takao Sakai the collagen-binding integrin, 2 1, and platelet-derived growth factor (PDGF) receptors in the context

Mosher, Deane F.

168

doi: 10.1111/j.1469-1809.2012.00726.x Association of the Vascular Endothelial Growth Factor

  Engineering Websites

Summary: doi: 10.1111/j.1469-1809.2012.00726.x Association of the Vascular Endothelial Growth Factor Gene Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent 9052, Belgium 8 Department Summary Published data on the association between the vascular endothelial growth factor (VEGF) gene ­460C


169

[CANCER RESEARCH 62, 37293735, July 1, 2002] Platelet-derived Growth Factor (PDGF) Autocrine Signaling Regulates Survival and

  Biology and Medicine Websites

Summary: [CANCER RESEARCH 62, 3729­3735, July 1, 2002] Platelet-derived Growth Factor (PDGF) Autocrine of the most common alterations being platelet-derived growth factor (PDGF) autocrine signaling characterized transcription-PCR. Expression of PDGF/PDGFR pairs that are known to functionally interact were identified in all


170

Leukemia . Author manuscript Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid

  Computer Technologies and Information Sciences Websites

Summary: Leukemia . Author manuscript Page /1 14 Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid receptor activation Anne Catherine Sprynski 1 2 , Dirk Hose 3 4 , Alboukadel Insulin and insulin growth factor type 1 (IGF-1) and their receptors are closely related molecules

Boyer, Edmond

171

902 Biochemical Society Transactions (2013) Volume 41, part 4 Nutrients and growth factors in mTORC1 activation

  Biology and Medicine Websites

Summary: 902 Biochemical Society Transactions (2013) Volume 41, part 4 Nutrients and growth factors in m, MA 02139, U.S.A., David H. Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts.S.A. Abstract Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin

Sabatini, David M.
2013-01-01

172

Observational calibration of the projection factor of Cepheids I. The Type II Cepheid kappa Pavonis

  CERN Preprints

Summary: The distances of pulsating stars, in particular Cepheids, are commonly measured using the parallax of pulsation technique. The different versions of this technique combine measurements of the linear diameter variation (from spectroscopy) and the angular diameter variation (from photometry or interferometry) amplitudes, to retrieve the distance in a quasi-geometrical way. However, the linear diameter amplitude is directly proportional to the projection factor (hereafter p-factor), which is used to convert spectroscopic radial velocities (i.e., disk integrated) into pulsating (i.e., photospheric) velocities. The value of the p-factor and its possible dependence on the pulsation period are still widely debated. Our goal is to measure an observational value of the p-factor of the type-II Cepheid kappa Pavonis, whose parallax was measured with an accuracy of 5% using HST/FGS. We used this parallax as a starting point to derive the p-factor of kappa Pav, using the SPIPS technique, which is a robust version of the p...

Breitfelder, Joanne; Mérand, Antoine; Gallenne, Alexandre; Szabados, Laszlo; Anderson, Richard; Willson, Matthew; Bouquin, Jean-Baptiste Le
2015-01-01

173

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial–mesenchymal transition

  CiteSeer

Summary: Abstract. Epithelial–mesenchymal transition (EMT) is an essential morphogenetic process during embryonic development. It can be induced in vitro by hepatocyte growth factor/scatter factor (HGF/SF), or by FGF-1 in our NBT-II cell model for EMT. We tested for a central role in EMT of a zinc-finger protein called Slug. Slug mRNA and protein levels were increased transiently in FGF-1–treated NBT-II cells. Transient or stable transfection of Slug cDNA in NBT-II cells resulted in a striking disappearance of the desmosomal markers desmoplakin and desmoglein from cell–cell contact areas, mimicking the initial steps of FGF-1 or HGF/SFinduced EMT. Stable transfectant cells expressed Slug protein and were less epithelial, with increased cell spreading and cell–cell separation in subconfluent cultures. Interestingly, NBT-II cells transfected with antisense Slug cDNA were able to resist EMT induction by FGF-1 or even HGF/SF. This antisense effect was suppressed by retransfection with Slug sense cDNA. Our results indicate that Slug induces the first phase of growth factor–induced EMT, including desmosome dissociation, cell spreading, and initiation of cell separation. Moreover, the antisense inhibition experiments suggest that Slug is also necessary for EMT. Epithelial cells adhere to each other through specialized structures essential for the maintenance of epithelial organization and differentiation. Among these, structures linked to the cytokeratin intermediate filament network appear to provide the strongest and most resilient adhesion (12, 15). The core unit of such structures is the desmosome, which appears early during epithelial differentiation (13, 24, 30, 37). Desmoglein and desmocollins are desmosome-specific cadherins that mediate cell– cell binding (15, 34). They are part of a molecular complex

Pierre Savagner; Kenneth M. Yamada; Jean Paul Thiery
1997-01-01

174

Mini-Review Some Recent Advances in the Chemistry and Biology of Transforming Growth Factor- Beta

  CiteSeer

Summary: ITHIN the past two years, there has been an exponential increase in research on transforming growth factor-beta (TGF-beta). ~ In this brief minireview, we cannot provide a detailed survey of this topic (see referenees 56 and 73 for other reviews). Rather, we will summarize some new results, indicative of the importance of this peptide as a multifunetional regulator of cellular activity. The term ~nultifunetional " implies that TGF-beta may either stimulate cell proliferation and growth, or inhibit cell proliferation and growth, or have numerous other actions having little relationship to either of these two processes. We will develop the theme that many of the actions of TGF-beta are related to the response of cells or tissues to stress or injury, and to the repair of resultant damage. However, it is clear that there is no one principal action for TGF-beta; moreover, the

Michael B. Sporn; Anita B. Roberts; Lalage M. Wakefield; Benoit De Crombrugghe

175

Mini-Review The Many Faces of Hepatocyte Growth Factor: from Hepatopoiesis to

  CiteSeer

Summary: ESEARCH performed over the past few years, in particular, has made it clear that, in addition to the liver, hepatocyte growth factor (HGF) 1 affects virtually every tissue in the body ranging from the nervous system to the immune and reticuloendothelial systems. Recent findings have also revealed that the biological responses of target cells to HGF are not confined to the induction of cell proliferation and motility per se but include a plethora of effects such as inhibition of cell growth, induction of morphogenesis, stimulation of T cell adhesion to endothelium and migration, enhancement of neuron survival, and regulation of erythroid differentiation. Furthermore, the discoveries of the HGF receptor as Met, of an HGF-related factor, called HGF-like protein, and of HGF-like's receptor as Ron, a transmembrane tyrosine kinase

Reza Zarnegar; George K. Michalopoulos

176

REVIEW Role of vascular endothelial growth factor in ovarian physiology – an overview

  CiteSeer

Summary: In the female reproductive system, as in a few adult tissues, angiogenesis occurs as a normal process and is essential for normal tissue growth and development. In the ovary, new blood vessel formation facilitates oxygen, nutrients, and hormone substrate delivery, and also secures transfer of different hormones to targeted cells. Ovarian follicle and the corpus luteum (CL) have been shown to produce several angiogenic factors, however, vascular endothelial growth factor (VEGF) is thought to play a paramount role in the regulation of normal and abnormal angiogenesis in the ovary. Expression of VEGF in ovarian follicles depends on follicular size. Inhibition of VEGF expression results in decreased follicle angiogenesis and the lack of the development of mature antral follicles. The permeabilizing activity of VEGF is thought to be involved in follicle antrum formation and in the ovulatory process. In the CL, VEGF expression corresponds to different patterns of angiogenesis during its lifespan. In most 1

Monika M. Kaczmarek; Dieter Schams; Adam J. Ziecik
2005-01-01

177

Latent Transforming Growth Factor- ? Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-?

  CiteSeer

Summary: Abstract. Transforming growth factor- ? (TGF-?) is secreted by many cell types as part of a large latent complex composed of three subunits: TGF-?, the TGF-? propeptide, and the latent TGF- ? binding protein (LTBP). To interact with its cell surface receptors, TGF- ? must be released from the latent complex by disrupting noncovalent interactions between mature TGF- ? and its propeptide. Previously, we identified LTBP-1 and transglutaminase, a cross-linking enzyme, as reactants involved in the formation of TGF-?. In this study, we demonstrate that LTBP-1 and large latent complex are substrates for transglutaminase. Furthermore, we show that the covalent association between LTBP-1 and the extracellular matrix is transglutaminase dependent, as little LTBP-1 is recovered from matrix

Irene Nunes; Pierre-emmanuel Gleizes; Christine N. Metz; Daniel B Rifkin

178

Growth factor control of skeletal muscle differentiation: commitment to terminal differntiation occurs in G1 phase and is repressed by fibroblast growth factor

  CiteSeer

Summary: Abstract. Analysis of MM14 mouse myoblasts demonstrates that terminal differentiation is repressed by pure preparations of both acidic and basic fibroblast growth factor (FGF). Basic FGF is ~30-fold more potent than acidic FGF and it exhibits half maximal activity in clonal assays at 0.03 ng/ml (2 pM). FGF repression occurs only during the G ~ phase of the cell cycle by a mechanism that appears to be independent of ongoing cell proliferation. When exponentially growing myoblasts are deprived of FGF, cells become postmitotic within 2-3 h, express muscle-specific proteins within 6-7 h, and commence fusion within 12-14 h. Although expression of these three terminal differentiation phenotypes occurs at different times, all are initiated by a single regulatory "commitment " event in G~. The entire population commits to terminal differentiation within 12.5 h of FGF removal as all cells complete the cell cycle and move into Gt. Differentiation does not require a new round of DNA synthesis. Comparison of MM14 behavior with other myoblast types suggests a general model for skeletal muscle development in which specific growth factors serve the dual role of stimulating myoblast proliferation and directly repressing terminal differentiation. S KE L Ea"A L muscle development involves an initial period of myoblast replication, followed by a phase in which some myoblasts continue to proliferate while others undergo terminal differentiation. The latter process involves the permanent cessation of DNA synthesis, activation of muscle-specific gene expression, and the fusion of single cells into multinucleated muscle fibers. In vitro studies indicate that the onset of terminal differentiation is delayed by media that are rich in serum and/or embryo extract components

Christopher H. Clegg; Thomas A. Linkhart; Bradley B. Olwin; Stephen D. Hauschka
1987-01-01

179

Competitive signalling between TrkA and p75 nerve growth factor receptor determines cell survival

  CiteSeer

Summary: In addition to its role as a survival factor, nerve growth factor (NGF) has been implicated in initiating apoptosis in restricted cell types both during development and after terminal cell differentiation. NGF binds to the TrkA tyrosine kinase and the p75 neurotrophin receptor, a member of the tumor necrosis factor cytokine family. To understand the mechanisms underlying survival versus death decisions, the TrkA receptor was introduced into oligodendrocyte cell cultures that undergo apoptosis in a p75-dependent manner. Here we report that activation of the TrkA NGF receptor in oligodendrocytes negates cell death by the p75 receptor. TrkA-mediated rescue from apoptosis correlated with mitogen-activated protein kinase activation. Concurrently, activation of TrkA in oligodendrocytes resulted in suppression of c-jun kinase activity initiated by p75, whereas induction of NF?B activity by p75 was unaffected.

Sung Ok Yoon; Patrizia Casaccia-bonnefil; Bruce Carter; Moses V. Chao
1998-01-01

180

The effect of crack surface interaction on the stress intensity factor in Mode III crack growth in round shafts

  Engineering Websites

Summary: is subjected to torsion. This interaction reduces the effective Mode III stress intensity factor. The effective show that asperity interactions significantly reduce the effective Mode III stress intensity factorThe effect of crack surface interaction on the stress intensity factor in Mode III crack growth

Vaziri, Ashkan

181

Vascular permeability factor (vascular endothelial growth factor gene is expressed differentially in normal tissues, macrophages and tumors

  CiteSeer

Summary: Persistent microvascular hyperpermeability to plasma proteins even after the cessation of injury is a characteristic but poorly understood feature of normal wound healing. It results in extravasation of fibrinogen that clots to form fibrin, which serves as a provisional matrix and promotes angiogenesis and scar formation. We present evidence indicating that vascular permeability factor (VPF; also known as vascular endothelial growth factor) may be responsible for the hyperpermeable state, as well as the angiogenesis, that are characteristic of healing wounds. Hyperpermeable blood vessels were identified in healing split-thickness guinea pig and rat punch biopsy skin wounds by their capacity to extravasate circulating macromolecular tracers (colloidal carbon, fluoresceinated dextran). Vascular permeability was maximal at 2-3 d, but persisted as late as 7 d after wounding. Leaky vessels were found initially at the wound edges and later in the subepidermal granulation tissue as keratinocytes migrated to cover the denuded wound surface. Angiogenesis was also prominent within this 7-d interval. In situ hybridization revealed that greatly increased amounts of VPF mRNA were expressed by keratinocytes, initially those at the wound edge, and, at later intervals, keratinocytes that migrated to cover the wound surface; occasional mononuclear cells also expressed VPF mRNA. Secreted VPF was detected by immunofluoroassay of medium from

F. Brown; Kiangteck Yeo; Brygida Berse; Tet-kin Yeo; Donald R Senger; Harold F. Dvorak; Livingston Van De
1992-01-01

182

Acceleration effect of basic fibroblast growth factor on the regeneration of peripheral nerve through a 15-mm gap

  Materials Science Websites

Summary: ; revised 8 October 2002; accepted 7 November 2002 Abstract: In this study, nerve guides composed of poly(d,l-lactide: poly(d,l-lactide); nerve guide; sciatic nerve; re- generation; basic fibroblast growth factor

Yang, Jian

183

Multivariate Perturbation of a Growth Factor-Cytokine Signalling Network Reveals Complex Systemic Responses in Glioblastoma Cells

  MIT - DSpace

Summary: Glioblastoma cells can evade TRAIL-induced apoptosis through various strategies involving the growth factor-activated MEK–MAPK/ERK and PI3K–Akt/PKB pro-survival signalling cascades. Although these signalling cascades have ...

Tang, Yew Chung

184

Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones

  CiteSeer

Summary: highly expressed in hypertrophic cartilage before osteoclast invasion. Hypertrophic cartilage also expresses vascular endothelial growth factor (VEGF), which binds to extracellular matrix and is made bioavailable by MMP-9

Michael T. Engsig; Qing-jun Chen; Thiennu H. Vu; Anne-cecilie Pedersen; Bente Therkidsen; Leif R. Lund; Kim Henriksen; Thomas Lenhard; Niels T. Foged; Zena Werb; Jean-marie Delaissé
2000-01-01

185

JK: Apert syndrome mutations in fibroblast growth factor receptor 2 exhibit increased affinity for FGF ligand. Hum Mol Genet

  CiteSeer

Summary: Dominantly acting mutations of the fibroblast growth factor (FGF) receptor 2 (FGFR2) gene have been implicated in various craniosynostosis syndromes. Apert syndrome, characterized in addition by syndactyly of the limbs, involves specific mutations at two adjacent residues, Ser252Trp and Pro253Arg, predicted to lie in the linker region between IgII and IgIII of the FGFR2 ligand-binding domain. We have analysed the interaction of FGF ligands with wild-type and Apert-type mutant FGFR2 ectodomains in solution. Wild-type and Apert-type receptors form a complex with FGF ligands with a stoichiometry of 2:2 (ligand:receptor). The kinetics and specificity of ligand binding to wild-type and Apert mutant receptors have been analysed using surface plasmon resonance techniques. This reveals that Apert mutations, compared with wild-type, exhibit a selective decrease in the dissociation kinetics of FGF2, but not of other FGF ligands examined. In contrast, the substitution Ser252Leu in FGFR2, previously observed in several asymptomatic individuals, exhibited wild-type kinetics. These findings indicate that Apert syndrome arises as a result of increased affinity of mutant receptors for specific FGF ligands which leads to activation of signalling under conditions where availability of ligand is limiting.

Jane Anderson; Helen D. Burns; Pita Enriquez-harris; Andrew O. M. Wilkie; John K. Heath
1998-01-01

186

Study of lung-metastasized prostate cancer cell line chemotaxis to epidermal growth factor with a BIOMEMS device

  Engineering Websites

Summary: Study of lung-metastasized prostate cancer cell line chemotaxis to epidermal growth factorpp) doi:10.1088/2043-6262/3/3/035007 Study of lung-metastasized prostate cancer cell line chemotaxis assaying of prostate cancer cell migration towards different growth factors. The device was created

Chiao, Jung-Chih

187

Molecular Cell, Vol. 12, 271280, August, 2003, Copyright 2003 by Cell Press ReviewIntegration of Growth Factor

  Biology and Medicine Websites

Summary: - is mutated in Cowden's disease, which is characterized by benign sebaceous (oil gland) tumors, as a well. In particular, we focus on the recent discovery that a tumor suppressor complex effectors for a growth factor or the nutrient signal leads to un- controlled growth. We focus on recent discoveries relat-mycin, which inhibits

Nghiem, Paul

188

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

  CiteSeer

Summary: The phosphatidylinositol 3-kinase (PI3K) signaling pathway has inherent oncogenic potential. It is upregulated in diverse human cancers by either a gain of function in PI3K itself or in its downstream target Akt or by a loss of function in the negative regulator PTEN. However, the complete consequences of this upregulation are not known. Here we show that insulin and epidermal growth factor or an inactivating mutation in the tumor suppressor PTEN specifically increase the protein levels of hypoxia-inducible factor (HIF) 1 ? but not of HIF-1 ? in human cancer cell lines. This specific elevation of HIF-1 ? protein expression requires PI3K signaling. In the prostate carcinomaderived cell lines PC-3 and DU145, insulin- and

Bing-hua Jiang; Guoqiang Jiang; Jenny Z. Zheng; Zhimin Lu; Tony Hunter; Peter K. Vogt
2000-01-01

189

Identification of a T cell-derived B cell growth factor distinct from interleukin

  CiteSeer

Summary: The importance of murine monokines and lymphokines in T cell immune responses has been emphasized by the development of T cell cloning technology (1) and the identification of cloned tumor lines that respond to or secrete these factors (2, 3). Such studies have shown that the monokine interleukin 1 (IL-1) 1 induces certain T cells to secrete interleukin 2 (IL-2), and that this lymphokine can maintain continuous in vitro proliferation of some T cell subsets. In contrast, the interaction of monokines and lymphokines with B cells is poorly understood, partly because of the lack of assays for B cell function in which contaminating accessory cells capable of mediating secondary effects have been excluded. We have recently described a procedure for the long-term culture of normal mouse B lymphocytes in which induced supernatants from a T cell hybridoma sustain slow proliferation of lipopolysaccharide-activated B cells for periods of up to 12 mo (4). This procedure implied the existence of a T cellderived growth factor that interacts with activated B lymphocytes to maintain proliferation. Here we identify such a factor in induced supernatants from the mouse thymoma EL4. This material is distinct from previously recognized factors, including

Maureen Howard; John Farrar; Mary Hilfiker; Barbara Johnson; Kiyoshi Takatsu; Toshiyuki Hamaoka; William E. Paul
1982-01-01

190

Original article Plasma levels of growth hormone

  Physics Websites

Summary: Original article Plasma levels of growth hormone and insulin-like growth factor-I and -II from 2 of the somatotrophic hormones of 2 genetic lines of broiler chickens selected for 6-wk body weight (GL (FC-line). Blood samples were collected weekly and analysed for growth hormone (GH) and insulin

Paris-Sud XI, Université de

191

PDL Class: Synthetic growth hormone-releasing factor analog Comparator Therapies: None Dossier received: Yes

  CiteSeer

Summary: FDA Approved Indications: Tesamorelin is a growth hormone releasing factor (GRF) analog indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. 1 Background/Reason for Review: Patients with human immunodeficiency virus (HIV) taking antiretroviral therapy frequently develop increased visceral adiposity, dyslipidemia, and insulin resistance, which may be associated with increased cardiovascular risk. Studies have shown that growth hormone-releasing hormone (GHRH) has shown positive changes in fat distribution in HIV-infected patients. 1, 2 Tesamorelin is a synthetic growth hormone-releasing factor analog that has been approved for the use of HIV infected patients with lipodystrophy. This review will evaluate the available evidence of efficacy, safety, and tolerability to further define its role in therapy and to identify potential parameters for use. Issues/Key questions: Is tesamorelin effective and safe for the treatment of excess abdominal fat in HIV-infected patients? Does treatment with tesamorelin result in improved health outcomes? Efficacy: There were two, Phase 3, randomized, controlled studies that evaluated the efficacy of tesamorelin compared to placebo; both studies conducted an initial 26-week phase and a 26-week extension phase to evaluate long-term safety. 7-9 Both studies saw a significant change in visceral adipose tissue (VAT) in patients treated with tesamorelin (-15.2 % and-10.9%) compared to placebo (+5.0 % and-0.6%, p<0.001 for both trials). Secondary efficacy endpoints from the extension phases indicate that this decrease in VAT is not maintained after treatment discontinuation. There was limited reduction in body mass index or waist circumference after 26 weeks after treatment with tesamorelin.

Executive Summary

192

Nerve growth factor (NGF), BDNF, neurotrophin-3 and neu-rotrophin 4/5 comprise the neurotrophin family of neu-

  Biology and Medicine Websites

Summary: Nerve growth factor (NGF), BDNF, neurotrophin-3 and neu- rotrophin 4/5 comprise the neurotrophin modulate the release of specific neurotransmitters. We found that activation of the p75 receptor--by BDNF-derived neurotrophic factor (BDNF) altered the neurotransmitter release properties of these sympathetic neuron

Birren, Susan J.

193

Regulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone in the

  Biology and Medicine Websites

Summary: in the immature mouse ovary This study investigated the regulation of Wilms' tumor gene (WT1) in the ovaryRegulation of Wilms' tumor gene expression by nerve growth factor and follicle-stimulating hormone their regulation of key transition genes or gene products. Wilms' tumor gene (WT1) encodes a transcription factor

Mayo, Kelly E.

194

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland

  CiteSeer

Summary: Abstract. We have examined the role of two mesenchymal ligands of epithelial tyrosine kinase receptors in mouse mammary gland morphogenesis. In organ cultures of mammary glands, hepatocyte growth factor (HGF, scatter factor) promoted branching of the ductal trees but inhibited the production of

Yanmin Yang; Eva Spitzer; Dirk Meyer; Martin Sachs; Catherin Niemann; Guido Hartmann; K. Michael Weidner; Carmen Birchmeier; Walter Birchmeier
1995-01-01

195

growth laws II). Hum. BioI. 10:181-213. IVLEV, V. S.

  Environmental Sciences and Ecology Websites

Summary: , W. E. 1966. "The biological productivity of waters" by V. S. IvIev. J. Fish. Res. Board Can. 23.] Zool. Zh. 18: 303-318. PALOHEIMO, J. E., AND L. M. DICKIE. 1966. Food and growth of fishes III. Relations among food, body size and growth efficiency. J. Fish. Res. Board Can. 23:1209-1248. PAULY, D. 1981


196

BRIEF REPORT Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia

  CiteSeer

Summary: OBJECTIVE—Fibroblast growth factor-21 (FGF-21) is a potent metabolic regulator, which in animal models has been shown to improve glucose metabolism and insulin sensitivity. Recently, FGF-21 was shown to be expressed and secreted from murine muscle cells in response to insulin stimulation. RESEARCH DESIGN AND METHODS—We studied muscular FGF-21 expression and plasma FGF-21 after acute insulin stimulation in young healthy men during a hyperinsulinemiceuglycemic clamp. Furthermore, we investigated systemic levels and muscle FGF-21 expression in humans with or without insulin resistance and chronic elevated insulin. RESULTS—FGF-21 was barely detectable in young healthy men before insulin infusion. After 3 or 4hofinsulin infusion during a hyperinsulinemic-euglycemic clamp, muscular FGF-21 expression increased significantly. Plasma FGF-21 followed the same

Pernille Hojman; Maria Pedersen; Anders Rinnov Nielsen; Rikke Krogh-madsen; Christina Yfanti; Thorbjørn Åkerstrom; Søren Nielsen; Bente Klarlund Pedersen

197

Expression of Fibroblast Growth Factor by F9 Teratocarcinoma Cells as a Function of Differentiation

  CiteSeer

Summary: Abstract. F9 teratocarcinoma stem cells treated with retinoic acid (RA) and dibutyryl cAMP (but2 cAMP) differentiate into embryonic parietal endoderm. Using heparin-attinity chromatography, endothelial cell proliferation assays, immunoprecipitation, and Western analysis with antibodies specific for acidic and basic fibroblast growth factors (FGFs), we detected biologically active FGF in F9 cells only after differentiation. A bovine basic FGF cDNA probe hybridized to 2.2-kb mRNAs in both F9 stem and parietal endoderm cells and to a 3.8-kb mRNA in F9 stem cells. A genomic DNA probe for acidic FGF hybridized to a 5.8-6.0-kb mRNA in both F9 stem and parietal endoderm cells, and to a 6.0-6.3-kb mRNA only in parietal endoderm cells. Although these FGF mRNAs were

Susan J. Braunhut; Lorraine J. Gudas; Tsutomu Kurokawa; Joachim Sasse; Patricia A. D' amore§ll

198

Distribution and modulation of the cellular receptor for transforming growth factor*Beta

  CiteSeer

Summary: Abstract. Scatchard analyses of the binding of transforming growth factor-beta (TGF-beta) to a wide variety of different cell types in culture revealed the universal presence of high affinity (Kd = 1-60 pM) receptors for TGF-beta on every cell type assayed, indicating a wide potential target range for TGF-beta action. There was a strong (r = +0.85) inverse relationship between the receptor affinity and the number of receptors expressed per cell, such that at low TGFbeta concentrations, essentially all cells bound a similar number of TGF-beta molecules per cell. The binding of TGF-beta to various cell types was not altered by many agents that affect the cellular response to TGF-beta, suggesting that modulation of TGF-beta binding to its receptor may not be a primary control

Lalage M. Wakefield; Diane M. Smith; Tohru Masui; Curtis C. Harris; Michael B. Sporn
1987-01-01

199

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

  CiteSeer

Summary: Abstract. The dissociation, migration, and remodeling of epithelial monolayers induced by hepatocyte growth factor (HGF) entail modifications in cell adhesion and in the actin cytoskeleton through unknown mechanisms. Here we report that ezrin, a membrane–cytoskeleton linker, is crucial to HGF-mediated morphogenesis in a polarized kidney-derived epithelial cell line, LLC-PK1. Ezrin is a substrate for the tyrosine kinase HGF receptor both in vitro and in vivo. HGF stimulation causes enrichment of ezrin recovered in the detergent-insoluble cytoskeleton fraction. Overproduction of wild-type ezrin, by stable transfection in LLC-PK1 cells, enhances cell migration and tubulogenesis induced by HGF stimulation. Overproduction of a truncated variant of ezrin causes mislocalization of endogenous

Tiziana Crepaldi; Alexis Gautreau; Paolo M. Comoglio; Daniel Louvard; Monique Arpin
1997-01-01

200

Re: Loss of Imprinting of Insulin-Like Growth Factor-II

  Biology and Medicine Websites

Summary: on the pathologic classification of Wilms tu- mors into perilobar nephrogenic rest (PLNR)-like or intralobarp13. Fourth, we found no difference in age at diagnosis for patients with Wilms tu- mors that did

Broman, Karl W.

201

Hydrogen isotope fractionation in freshwater and marine algae: II. Temperature and nitrogen limited growth rate effects

  Geosciences Websites

Summary: Hydrogen isotope fractionation in freshwater and marine algae: II. Temperature and nitrogen limited Accepted 7 November 2008 Available online 17 November 2008 a b s t r a c t Zhang and Sachs [Hydrogen. Introduction Hydrogen isotope ratios in plant and algal lipids from sediments are increasingly used

Sachs, Julian P.

202

Growth and Destruction of Disks: Combined H I and H II View

  Physics Websites

Summary: and H II View May 12, 2008 1 #12;FIGURE 1. The blue cloud and red sequence in a deep field around MS0451 and the Milky Way today. In denser environments, it appears they transform onto the red sequence. Tracking disk but retaining sensitivity to disk outskirts. THE BLUE CLOUD AND RED SEQUENCE A general but powerful statement

Bershady, Matthew A.

203

Growth and Characterization of Novel Optoelectronic Materials Based on II-VI Inorganic/Organic

  CiteSeer

Summary: ABSTRACT: Novel optoelectronic materials based on II-VI inorganic/organic low-dimensional heterostructure were successfully grown by electron beam evaporator. The structures were based on ZnSe, tris(8-hydroxyquinoline) aluminum (Alq 3) and N,N’–bis(3-methylphenyl)-N,N’–diphenyl-benzidine (TPD). The

Wisanu Pecharapa; Anusit Keawprajak; Nawapun Kayunkid; Sakon Rahong; Witoon Yindeesuk; Jiti Nukeaw
2006-01-01

204

Developmental Changes of Plasma Insulin, Glucagon, Insulin-like Growth Factors, Thyroid Hormones, and Glucose Concentrations in Chick Embryos and Hatched Chicks

  CiteSeer

Summary: ABSTRACT Developmental hormonal changes in Cobb the anabolic drive to promote protein deposition. Insulin 500 chick embryos and hatched chicks were determined by measuring plasma insulin, glucagon, insulin-like growth factor (IGF)-I, IGF-II, triiodothyronine, thyroxine, and glucose concentrations at different ages of embryogenesis and posthatch development. Plasma samples were obtained daily from 10 d of embryogenesis (10E) through 13 d posthatch and also at 17 and 21 d posthatch. A significant increase in plasma insulin was observed with increasing age from 10E to hatch. Plasma glucagon levels remained low until 17E, and then significantly increased approximately 3-fold at hatch, which corresponded with increasing plasma glucose levels during late embryo development. The plasma insulin to glucagon molar ratio of incubation from 14E to 17E ranged from 2

J. W. Lu; J. P. Mcmurtry; C. N. Coon

205

Damping of the baryon acoustic oscillations in the matter power spectrum as a probe of the growth factor

  Astrophysics (arXiv)

Summary: We investigate the damping of the baryon acoustic oscillations (BAO) signature in the matter power spectrum due to the quasi-nonlinear clustering of density perturbations. On the basis of the third order perturbation theory, we construct a fitting formula of the damping in an analytic way. This demonstrates that the damping is closely related with the growth factor and the amplitude of the matter power spectrum. Then, we investigate the feasibility of constraining the growth factor through a measurement of the damping of the BAO signature. An extension of our formula including higher order corrections of density perturbations is also discussed.

Hidenori Nomura; Kazuhiro Yamamoto; Takahiro Nishimichi
2008-10-20

206

Evolution and Growth of Virtual Plants Universitat Wurzburg, Lehrstuhl fur Informatik II

  Computer Technologies and Information Sciences Websites

Summary: Evolution and Growth of Virtual Plants Marc Ebner UniversitË?at WË?urzburg, Lehrstuhl fË?ur Informatik plants. Plants are modeled using Lindenmayer systems and rendered with OpenGL. The plants consist as their structural complexity. All plants are evaluated inside the same environ­ ment, which means that one plant

Ebner, Marc

207

SMBH growth parameters in the early Universe of Millennium and Millennium-II simulations

  CERN Preprints

Summary: We make BH merger trees from Millennium and Millennium-II Simulations to find under what conditions 10^9Msun SMBH can form by redshift z=7. In order to exploit both: large box size in the Millennium Simulation; and large mass resolution in the Millennium-II Simulation, we develop a method to combine these two simulations together, and use the Millennium-II merger trees to predict the BH seeds to be used in the Millennium merger trees. We run multiple semi-analytical simulations where SMBHs grow through mergers and episodes of gas accretion triggered by major mergers. As a constraint, we use observed BH mass function at redshift z=6. We find that in the light of the recent observations of moderate super-Eddington accretion, low mass seeds (100Msun) could be the progenitors of high redshift SMBHs (z~7), as long as the accretion during the accretion episodes is moderately super-Eddington, where f_Edd=3.7 is the effective Eddington ratio averaged over 50 Myr.

Smole, Majda; Martinovic, Nemanja
2015-01-01

208

Developing Schwann cells acquire the ability to survive without axons by establishing an autocrine circuit involving insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB

  CiteSeer

Summary: Although Schwann cell precursors from early embryonic nerves die in the absence of axonal signals, Schwann cells in older nerves can survive in the absence of axons in the distal stump of transected nerves. This is crucially important, because successful axonal regrowth in a damaged nerve depends on interactions with living Schwann cells in the denervated distal stump. Here we show that Schwann cells acquire the ability to survive without axons by establishing an autocrine survival loop. This mechanism is absent in precursors. We show that insulin-like growth factor, neurotrophin-3, and platelet-derived growth factor-BB are important components of this autocrine survival signal. The secretion of these factors by Schwann cells has significant implications for cellular communication in developing nerves, in view of their known ability to regulate survival and differentiation of other cells including neurons.

Carola Meier; Eric Parmantier; Angela Brennan; Rhona Mirsky; Kristjan R. Jessen
1999-01-01

209

A minor fraction of basic fibroblast growth factor mRNA is deaminated in Xenopus stage VI

  Biology and Medicine Websites

Summary: transcripts of basic fibroblast growth factor (bFGF), is protected in a similar manner. Consistent with the presence of cyto-dsRBP, we observed that the majority of bFGF RNA was not deaminated, before or after maturation. However, a minor fraction of the bFGF RNA was deaminated whether the RNA was isolated from stage

Bass, Brenda L.

210

Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells

  Physics Websites

Summary: . Neither bFGF nor NT3 influences the proportion of glia or neurons in short to medium term cultures; bFGF; NT3; corticogenesis INTRODUCTION Cortical stem cells from the ventricular zone are responsible, Ecole Normale Supérieure de Lyon, 69364 Lyon, France ABSTRACT Basic fibroblast growth factor (bFGF

Paris-Sud XI, Université de

211

Epidermal Growth Factor Receptors Are Localized to Lipid Rafts That Contain a Balance of Inner and Outer Leaflet Lipids

  Biology and Medicine Websites

Summary: 63110 The epidermal growth factor (EGF) receptor parti- tions into lipid rafts made using a detergent-free method, but is extracted from low density fractions by Triton X-100. By screening several detergents, we iden- tified Brij 98 as a detergent in which the EGF receptor is retained in detergent

Pike, Linda J.

212

Transforming Growth Factor-3 Restores Fusion in Palatal Shelves Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin*

  Biology and Medicine Websites

Summary: Transforming Growth Factor- 3 Restores Fusion in Palatal Shelves Exposed to 2 of Wisconsin Medical School, Madison, Wisconsin 53706 The pollutant, 2,3,7,8-tetrachlorodibenzo at a nearby chlorinated-phenol plant (10­12). Epidemiological studies performed after many of these high

Bradfield, Christopher A.

213

Theoretical Population Biology 71 (2007) 8094 The effect of size-dependent growth and environmental factors on

  Environmental Sciences and Ecology Websites

Summary: and environmental factors on animal size variability Scott D. Peacora,b,Ã, James R. Bencea , Catherine A. Pfisterc variation in size observed in animals from the same cohort reared together in controlled conditionsTheoretical Population Biology 71 (2007) 80­94 The effect of size-dependent growth


2007-01-01

214

Systematic assessment of growth factor treatment on biochemical and biomechanical properties of engineered articular cartilage constructs1

  Engineering Websites

Summary: : To determine the effects of bone morphogenetic protein-2 (BMP-2), insulin-like growth factor (IGF of BMP-2, IGF-I, and TGF-b1, at two concentrations and two dosage frequencies each were assessed-seeded PGA scaffolds, and indicated that treatment with bone morphogenetic protein-2 (BMP-2) and in- sulin

Athanasiou, Kyriacos

215

The Effects of Nerve Growth Factor on Spatial Recent Memory in Aged Rats Persist after Discontinuation of Treatment

  Biology and Medicine Websites

Summary: 21205 Nerve growth factor (NGF) infusion significantly reduces spatial recent memory deficits in aged examined. Four- and 22-month-old rats were tested preoper- atively, infused intraventricularly with recombinant human NGF or vehicle, and tested both during the 4 week infusion period and during the 4 weeks

Frick, Karyn M.

216

Facile growth factor immobilization platform based on engineered phage So Young Yoo, Anna Merzlyak and Seung-Wuk Lee*

  Materials Science Websites

Summary: and cell morphology. We report a strategy for immobilizing growth factors on genetically engineered phage matrices for tissue regeneration. We modified M13 phages to express biotin-like peptides (HPQ) and of numerous cell types. Designing biomimetic materials with precisely controlled structural organization

Lee, Seung-Wuk

217

In recent years, informatics studies have predicted several new ways in which the transforming growth factor b (TGFb)

  Biology and Medicine Websites

Summary: of highly conserved developmental signaling proteins, which are encoded as multigene families, such as the transforming growth factor b (TGFb) family, perform a multitude of tasks. To illustrate the versatility of these signaling molecules, we note just a few of the documented roles that TGFb family members play in mammals

Newfeld, Stuart J.

218

Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells

  Biology and Medicine Websites

Summary: . Individual delivery of BMP2 or TGF-h3 resulted in negligible bone tissue formation up to 22 weeks, regardless of exogenous growth factors are typically required to obtain bone regeneration, and it is unclear why lower to be used for therapeutic bone regeneration. We tested this hypothesis by measuring bone formation by rat

Simmons, Craig A.

219

Bioprinting of growth factors onto aligned sub-micron fibrous scaffolds for simultaneous control of cell differentiation and alignment

  Engineering Websites

Summary: (FGF-2) or bone-promoting bone morphogenetic protein-2 (BMP-2) prior to seeding with mouse C2C12 differentiation while printed FGF-2 and BMP-2 patterns promoted tenocyte and osteoblast fates, respectively 2011 Available online 5 August 2011 Keywords: Bone Muscle Tendon Growth factors a b s t r a c

Weiss, Lee E.

220

Impact of body condition on plasma leptin and insulin-like growth factor-I concentrations in stallions and geldings

  Texas A&M University - TxSpace

Summary: The objective of this study was to more clearly define the relationship between body condition, plasma leptin and insulin-like growth factor-I (IGF-I) in stallions and geldings in moderate (5.0-5.5) versus fleshy (7.0-7.5) body condition. Data...

Chancellor, Tommy Neal
2009-05-15

221

Transforming Growth Factor (TGF ) Mediates Schwann Cell Death In Vitro and In Vivo: Examination of c-Jun Activation,

  Biology and Medicine Websites

Summary: Transforming Growth Factor (TGF ) Mediates Schwann Cell Death In Vitro and In Vivo: Examination to Schwann Cell Differentiation David B. Parkinson,1 Ziping Dong,4 Howard Bunting,1 Jonathan Whitfield,3 Neuroanatomie, Med. Einrichtungen der Ruhr-Universita¨ t, 44780 Bochum, Germany In some situations, cell death

Jessen, Kristjan R

222

1583Journal of Thoracic Oncology Volume7,Number10,October2012 Introduction: Erlotinib (Tarceva) is an epidermal growth factor

  Biology and Medicine Websites

Summary: ) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which effectively tar- gets EGFR faster, even if make-up doses are attempted. Conclusions: For existing and new kinase inhibitors-molecule tyrosine kinase inhibitors (TKIs) in cancer therapy is that prolonged target inhibition is essential. Thus


223

Cyclic Adenosine 3',5'-Monophosphate-Elevating Agents Inhibit Transforming Growth Factor--Induced SMAD3/4-Dependent

  Physics Websites

Summary: activator inhibitor-1; PGE2, prostaglandin E2; PKA: protein kinase A; TGF-, transforming growth factor--Induced SMAD3/4-Dependent Transcription Via a Protein Kinase A-Dependent Mechanism Meinhard Schiller, Frank, plasminogen activator inhibitor 1, we show that membrane- permeable dibutyryl cAMP, and other intracellular c

Paris-Sud XI, Université de

224

and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta. Invest Ophthalmol Vis Sci

  CiteSeer

Summary: PURPOSE. To determine the genomic and proteomic expression changes in human trabecular meshwork cells when they are treated with transforming growth factor (TGF)-?. METHODS. Human trabecular meshwork cells from five donors were cultured for 3 days with 1 ng/mL of either TGF-?1 or-?2. Changes in

Xiujun Zhao; Keri E. Ramsey; Dietrich A. Stephan; Paul Russell

225

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors

  Biology and Medicine Websites

Summary: Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors Ellen G; accepted 26 April 2000 Abstract The human Surf-1 and Surf-2 genes are divergently transcribed and share transcription in the Surf-1 direction, but has no effect on transcription in the Surf-2 direction. Mutations

Gaston, Kevin

226

The transforming growth factor-(TGF) family of proteins is a large group of secreted pleiotropic cytokines

  Chemistry Websites

Summary: The transforming growth factor- (TGF) family of proteins is a large group of secreted pleiotropic transcriptional programmes. The TGF-family members are critically important in the early development of multiple types that deliver the functional cytokine very difficult. However, recent studies that use genetic

Cai, Long

227

Regulation of Trypanosoma cruzi infections in vitro, and in vivo by transforming growth factor

  CiteSeer

Summary: The effects of transforming growth factor a (TGF-a) on interferon y-mediated killing of the intracellular protozoan parasite Trypanosoma cruzi and on the course of T. cruzi infection in mice were investigated. Spleen cells from mice with acute T. cruzi infections were found to produce elevated levels of biologically active TGF-0 in vitro, and the possibility that TGF-0 may mediate certain aspects of T. cruzi infection was then addressed. When mouse peritoneal macrophages were treated with TGF-0 in vitro, the ability of IFN-y to activate intracellular inhibition of the parasite was blocked. This occurred whether cells were treated with TGF-0 either before or after IFN-y treatment. TGF-0 treatment also blocked the T. cruzi-inhibiting effects of IFN-y on human macrophages. Additionally, treatment of human macrophages with TGF-0 alone led to increased parasite replication in these cells. The effects of TGF-0 on T. cruzi infection in vivo were then investigated. Susceptible C57BL/6 mice developed higher parasitemias and died earlier when treated with TGF-0 during the course of infection. Resistant C57BL/6 x DBA/2 F1 mice treated with TGF-0 also had increased parasitemias, and 50 % mortality, compared with no mortality in infected, saline-treated controls. A single dose of TGF-R, given at the time of infection, was sufficient to significantly decrease resistance to infection in F1 mice and to exacerbate

S. Silva; Daniel R Twardzik; Steven G. Reed
1991-01-01

228

Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilagederived growth factor

  CiteSeer

Summary: ABSTRACT Cartilage-derived growth factor (CDGF), a cationic polypeptide of ~18,000 mol wt, was prepared from bovine articular cartilage; other sources were bovine and human scapular and costal cartilage. Previous studies have shown that CDGF stimulates the proliferation of cultured mouse fibroblasts as well as chondrocytes and endothelial cells from various sources. In this study, CDGF was shown to stimulate dose-dependently the accumulation of DNA and collagen by rat embryo fibroblasts and a population of fibroblasts derived from granulation tissue. CDGF also stimulated the proliferation of cultured bovine capillary endothelial cells dose-dependently. To evaluate the effects of CDGF in vivo, we implanted polyvinyl alcohol sponges subcutaneously in rats. 6 d postimplantation, sponges were injected with 300 pg of partially purified CDGF, a dose which takes into account the cell numbers in the sponges as compared with cell cultures. CDGF rapidly disappeared from the sponges and only ~10% of the initial dose was present at 4 h. Despite its transient presence, CDGF caused a relative increase in sponge DNA content of 2.6-fold at 48 h and 2.4-fold at 72 h. We repeated the sponge experiment by using 500-ng injections of CDGF purified to near homogeneity by heparin-Sepharose chromatography. Purified CDGF caused significant increases in sponge

Jeffrey M. Davidson; Michael Klagsbrun; Kenneth E. Hill; Anne Buckley; Robert Sullivan; Pamela S. Brewer; Stephen C. Woodward
1975-01-01

229

125I-LABELED HUMAN EPIDERMAL GROWTH FACTOR Binding, Internalization, and Degradation in

  CiteSeer

Summary: ~z~I-labeled human epidermal growth factor (hEGF) binds in a specific and saturable manner to human fibroblasts. At 37 ~ the cell-bound ~25I-hEGF initially may be recovered in a native form by acid extraction; upon subsequent incubation, the cell-bound ~25I-hEGF is degraded very rapidly, with the appearance in the medium of 125I-monoiodotyrosine. At 0 ~ cell-bound nSI-hEGF is not degraded but slowly dissociates from the cell. The data are consistent with a mechanism in which ~zSI-hEGF initially is bound to the cell surface and subsequently is internalized before degradation. The degradation is blocked by inhibitors of metabolic energy production (azide, cyanide, dinitrophenol), some protease inhibitors (Tos-Lys-CH2CI, benzyl guanidobenzoate), a lysosomotropic agent (chloroquine), various local anesthetics (cocaine, lidocaine, procaine), and ammonium chloride. After the binding and degradation of ~25I-hEGF, the fibroblasts are no longer able to rebind fresh hormone. The binding capacity of these cells is restored by


230

Epidermal growth factor receptor status as predictor of early recurrence of and death from breast cancer

  CiteSeer

Summary: The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptors have all recurred within two years of resection. Twenty-one percent of the lobular carcinomas contained EGF receptors compared to 34 % of ductal carcinomas. EGF receptor status appeared to be associated with an increased risk of early recurrence and death whatever the histological sub-type of the breast cancer. Many prognostic variables have been described for use in the study of breast cancer. Patient variables (such as age at menarche or parity) and clinical findings (such as palpable lymph nodes) give useful information. Study of the resected specimen allows assessment of further variables. Size of the lesion is most accurately measured by the pathologist as is the involvement of lymph nodes with tumour. Various histological scoring systems

J. R. C. Sainsbury; S. Nicholson; B. Angus; J. R. Farndon; A. J. Malcolm; A. L. Harris
1987-01-01

231

Modelling the effect of endogenous growth factor signalling using a combined agent -

  Computer Technologies and Information Sciences Websites

Summary: plating density and 2) cell distribution on population growth. We have demonstrated that EGFR-mediated population growth is affected by cell density, but not cell distribution. RESULTS: 1. Seeding Density The influence of cell seeding density on endogenous EGFR signalling and hence population growth was explored

Walker, Dawn

232

J. Phi-s-II FYance 7 (1997) 1123-1139 AuGusT 1997, PAGE 1123 Inter-Chain Structure Factors of Flexible Polylners in Solutions

  Physics Websites

Summary: J. Phi-s- II FYance 7 (1997) 1123-1139 AuGusT 1997, PAGE 1123 Inter-Chain Structure Factors of both the single chain structure factor h(q) and the inter-chain structure factor HD(q) of flexible the dilute to the concentrated regime, for chain lengths up to N = 256. The single chain properties (gyration

Paris-Sud XI, Université de

233

In Ovo Administration of Recombinant Human Insulin-Like Growth Factor-I Alters Postnatal Growth and Development of the Broiler Chicken

  CiteSeer

Summary: ABSTRACT Two experiments assessed the efficacy of in ovo administration of insulin-like growth factor-I (IGF-I) to enhance skeletal muscle development and improve feed efficiency of broilers. Hatching eggs were divided into three groups: uninjected control, vehicleinjected control, and recombinant human (rh) IGF-I (100 ng per embryo). Eggs in Experiment 1 were injected on Day 1, 4, or one of Day 7 through 18 of incubation. Growth rates for Days 1 and 4 resulted in the greatest response to treatment (P < 0.01, P < 0.06 respectively). Based on these results, Experiment 2 focused on Days 1 to 4 of incubation. Results from Experiment 2 showed that there was no significant difference in hatchability among control and rh IGF-I treatment groups. Injection on Day 3 resulted in the greatest response for increased live (P < 0.035) and leg (P < 0.02) weights in both sexes. Feed efficiencies of all rh IGF-I groups were significantly (P < 0.01) improved for the first 3 wk. In ovo administration of rh IGF-I on Day 3 increased feed efficiency (6.65%; P < 0.009) in pens of mixed-sex broilers. In addition, live weights (12.3%; P < 0.002), leg weights (11.7%; P < 0.01), breast weights (9.9%; P < 0.04), and heart weights (11.4%; P < 0.02) were increased in males. These results demonstrate that in ovo administration of rh IGF-I alters feed efficiency, growth, and tissue development. This finding lends itself to significant improvements in broiler production efficiency and profitability. (Key words: in ovo administration, insulin-like growth factor-I, feed efficiency, growth, muscle)

H. Kocamis; D. C. Kirkpatrick-keller; H. Klandorf; J. Killefer

234

Environmentally Relevant Concentrations of 17a-Ethinylestradiol (EE2) Interfere With the Growth Hormone (GH)/Insulin-Like Growth Factor (IGF)-I System in Developing Bony Fish

  CiteSeer

Summary: The aim of this study was to evaluate whether effects of environmental estrogens on fish growth and reproduction may be mediated via modulating the growth hormone (GH)/insulin-like growth factor I (IGF-I) system. To this end, developing male and female monosex populations of tilapia were exposed to

Natallia Shved; Giorgi Berishvili; Jean-francxois Baroiller; Helmut Segner; Manfred Reinecke
2008-01-01

235

Large time asymptotics of growth models on space-like paths II: PNG and parallel TASEP

  Mathematical Physics (arXiv)

Summary: We consider the polynuclear growth (PNG) model in 1+1 dimension with flat initial condition and no extra constraints. The joint distributions of surface height at finitely many points at a fixed time moment are given as marginals of a signed determinantal point process. The long time scaling limit of the surface height is shown to coincide with the Airy_1 process. This result holds more generally for the observation points located along any space-like path in the space-time plane. We also obtain the corresponding results for the discrete time TASEP (totally asymmetric simple exclusion process) with parallel update.

Alexei Borodin; Patrik L. Ferrari; Tomohiro Sasamoto
2007-07-28

236

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor ? 1

  CiteSeer

Summary: Interleukin (IL)-13 is a key mediator of tissue fibrosis caused by T helper cell type 2 inflammation. We hypothesized that the fibrogenic effects of IL-13 are mediated by transforming growth factor (TGF)-?. To test this hypothesis we compared the regulation of TGF- ? in lungs from wild-type mice and CC10-IL-13 mice in which IL-13 overexpression causes pulmonary fibrosis. IL-13 selectively stimulated TGF- ? 1 production in transgenic animals and macrophages were the major site of TGF- ? 1 production and deposition in these tissues. IL-13 also activated TGF- ? 1 in vivo. This activation was associated with decreased levels of mRNA encoding latent TGF-?–binding protein-1 and increased mRNA encoding urinary plasminogen activator, matrix metalloproteinase (MMP)-9, and CD44. TGF- ? 1 activation was abrogated by the plasmin/serine protease antagonist aprotinin. It was also decreased in progeny of crosses of CC10-IL-13 mice and MMP-9 null mice but was not altered in crosses with CD44 null animals. IL-13–induced fibrosis was also significantly ameliorated by treatment with the TGF- ? antagonist soluble TGF?R-Fc (sTGF?R-Fc). These studies demonstrate that IL-13 is a potent stimulator and activator of TGF- ? 1 in vivo. They also demonstrate that this activation is mediated by a plasmin/serine protease- and MMP-9–dependent and CD44-independent mechanism(s) and that the fibrogenic effects of IL-13 are mediated, in great extent, by this TGF- ? pathway. Key words: lung • plasmin • matrix metalloproteinase-9 • CD44 • asthma

Chun Geun Lee; Robert J. Homer; Zhou Zhu; Sophie Lanone; Xiaoman Wang; Victor Koteliansky; J. Michael Shipley; Philip Gotwals; Paul Noble; Qingsheng Chen; Robert M. Senior; Jack A. Elias
2001-01-01

237

Recycling of Epidermal Growth Factor-Receptor Complexes in A431 Cells: Identification of Dual Pathways

  CiteSeer

Summary: Abstract. The intracellular sorting of EGF-receptor complexes (EGFoRC) has been studied in human epidermoid carcinoma A431 cells. Recycling of EGF was found to occur rapidly after internalization at 37"C. The initial rate of EGF recycling was reduced at 18°C. A significant pool of internalized EGF was incapable of recycling at 18°C but began to recycle when cells were warmed to 37°C. The relative rate of EGF outflow at 370C from ceils exposed to an 18°C temperature block was slower (tla = 20 min) than the rate from cells not exposed to a temperature block (tv2 = 5-7 min). These data suggest that there might be both short- and long-time cycles of EGF recycling in A431 cells. Examination of the intraceUular EGF-RC dissociation and dynamics of short- and long-time recycling indicated that EGF recycled as EGF-RC. Moreover, EGF receptors that were covalently labeled with a photoactivatable derivative of 125I-EGF recycled via the long-time pathway at a rate similar to that of t25I-EGF. Since EGF-RC degradation was also blocked at 18°C, we propose that sorting to the lysosomal and long-time recycling pathway may occur after a highly temperature-sensitive step, presumably in the late endosomes. M ANY serum proteins, hormones, growth factors, and viruses are carried into the cell by receptormediated endocytosis. Ligand-receptor complexes formed at the cell surface are internalized via coated pits and transported to the membrane system of the endosomal compat~auent. This compartment represents several types of tubular-vesicular organelles that differ in morphology


238

Inhibition of basic fibroblast growth factor expression, angiogenesis, and growth of human bladder carcinoma in mice by systemic interferon-? administration. Cancer Res

  CiteSeer

Summary: The purpose of these studies was to determine whether systemic ad ministration of IFN-a can inhibit the expression of basic fibroblast growth factor (bFGF) in human transitional cell carcinoma, reduce its angiogenesis, and thus inhibit its growth in the bladder wall of nude mice. In vitro incubation of the highly metastatic 253J B-V cells and the IFN-a-resistant 253J B-V IFNR cells with noncytostatic concentrations of IFN-a downregulated the steady-state niKNA transcripts and protein production of bFGF. IFN-a-insensitive and IFN-a-resistant cells were implanted in the bladder wall of nude mice. Systemic administration of IFN-a decreased the in vivo expression of bFGF, decreased blood vessel density in the tumors, and inhibited tumor growth of both IFN-a-insensitive and IFNa-resistant cells. These data suggest that in addition to its well-docu mented antiproliferative effects, IFN-a can inhibit the growth of human bladder cancer cells by inhibition of angiogenesis.

Colin P. N. Dinney; Diane R. Bielenberg; Paul Perrotte; Et Al; Cancer Res; Contact The Aacr Publications; Colin P. N. Dinney; Diane R. Bielenberg; Paul Perrotte; Reuven Reich; Beryl Y. Eve; Corazãn D. Bucana; Isaiah J. Fidler
1998-01-01

239

Growth, atomic structure, and type-II band alignment of GaSb/GaAs nanostructures: Quantum wells, dots, and rings

  Mathematics Websites

Summary: Growth, atomic structure, and type-II band alignment of GaSb/GaAs nanostructures: Quantum wells as by the European Commission in the SANDiE Network of Excellence. References ! ! ! ! ! ! R. Timm, H. Eisele, A. Lenz, S. K. Becker, J. Grabowski, T.-Y. Kim, L. Müller-Kirsch, K. Pötschke, U. W. Pohl, D. Bimberg, and M

Nabben, Reinhard

240

Sequences of B-Chain/Domain 1-10/1-9 of Insulin and Insulin-like Growth Factor 1 Determine Their Different Folding Behavior

  Biology and Medicine Websites

Summary: Sequences of B-Chain/Domain 1-10/1-9 of Insulin and Insulin-like Growth Factor 1 DetermineVed February 9, 2004; ReVised Manuscript ReceiVed May 14, 2004 ABSTRACT: Although insulin and insulin-like growth factor-1 (IGF-1) belong to one family, insulin folds into one thermodynamically stable structure

Tian, Weidong

241

The Different Folding Behavior of Insulin and Insulin-like Growth Factor 1 Is Mainly Controlled by Their B-Chain/Domain

  Biology and Medicine Websites

Summary: The Different Folding Behavior of Insulin and Insulin-like Growth Factor 1 Is Mainly ControlledVed October 19, 2001 ABSTRACT: Although insulin and insulin-like growth factor 1 (IGF-1) share homologous highly homologous sequences encode different folding behavior: insulin folds into one unique stable

Tian, Weidong

242

Using DNA Microarray to Identify Sp1 as a Transcriptional Regulatory Element of Insulin-like Growth Factor-1 in Cardiac Muscle Cells

  Computer Technologies and Information Sciences Websites

Summary: 1 Using DNA Microarray to Identify Sp1 as a Transcriptional Regulatory Element of Insulin a computational strategy to identify common promoter motifs that respond to insulin-like growth factor-1 (IGF-1 in the promoter region. Insulin-like growth factor 1 (IGF-1) modulates myocardial gene expression and regulates

Kibler, Dennis F.

243

Effects of growth hormone and insulinlike growth factor I on salinity tolerance and gill Na + ,K + -ATPase in Atlantic salmon (Salmo salar): Interaction with cortisol. Gen

  CiteSeer

Summary: The potential roles of growth hormone (GH) and insulin-like growth factor I (IGF-I) in seawater (SW) acclimation of juvenile Atlantic salmon (Salmo salar) were examined. Compared to controls, fish in 12 ppt seawater given one or three injections (2–6 days) of GH (ovine, 0.2 µg ·g ?1) or IGF-I (recombinant bovine, 0.05–0.2 µg ·g ?1) had significantly greater salinity tolerance as judged by lower plasma sodium, osmolality, and muscle moisture content following transfer to 34 ppt. Single injections of GH and IGF-I in fish in fresh water failed to improve salinity tolerance following transfer to 25 ppt SW. Treatment of fish in 12 ppt with GH or IGF-I for 2–6 days did not increase gill Na +,K +-ATPase activity, but treatment with GH prevented decreases in gill Na +, K +-ATPase activity that occurred in controls following

Stephen D. Mccormick
1996-01-01

244

Scatter Factor/Hepatocyte Growth Factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development

  CiteSeer

Summary: Abstract. Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro. The cell surface receptor for this factor was recently identified: it is the product of the c-met protooncogene, a receptor-type tyrosine kinase. We report here the novel and distinct expression patterns of SF/HGF and its receptor during mouse development, which was determined by a combination of in situ hybridization and RNase protection experiments. Predominantly, we detect transcripts of c-met in epithelial cells of various developing organs, whereas the ligand is expressed in distinct mesenchymal cells in close vicinity. In addition, transient SF/HGF and c-met expression is found at certain sites of muscle formation; transient expres-

Eva Sonnenberg; Dirk Meyer; K. Michael Weidner; Carmen Birchmeier
1993-01-01

245

Targeted Overexpression of Insulin-Like Growth Factor I to Osteoblasts of Transgenic Mice: Increased

  Biology and Medicine Websites

Summary: in the osteocyte la- cunea occupancy, suggesting that IGF-I may extend the osteocyte life span. We conclude, and osteocytes and deposited into bone matrix. In the rodent, IGF-II is believed to function primarily to control

Pike, J. Wesley

246

On The Structure Of The Chan-Paton Factors For D-Branes In Type II Orientifolds

  HEP - Theory (arXiv)

Summary: We determine the structure of the Chan-Paton factors of the open strings ending on space filling D-branes in Type II orientifolds. Through the analysis, we obtain a rule concerning possible distribution of O-plane types. The result is applied to classify the topology of D-branes in terms of Fredholm operators and K-theory, deriving a proposal made earlier and extending it to more general cases. It is also applied to compactifications with N=1 supersymmetry in four-dimensions. We adapt and develop the language of category in this context, and use it to describe some decay channels.

Dongfeng Gao; Kentaro Hori
2010-04-22

247

Strange and singlet form factors of the nucleon: Predictions for G0, A4, and HAPPEX-II experiments

  HEP - Phenomenology (arXiv)

Summary: We investigate the strange and flavor-singlet electric and magnetic form factors of the nucleon within the framework of the SU(3) chiral quark-soliton model. Isospin symmetry is assumed and the symmetry-conserving SU(3) quantization is employed, rotational and strange quark mass corrections being included. For the experiments G0, A4, and HAPPEX-II we predict the quantities $G^{0}_E + \\beta G^{0}_M$ and $G^{\\rm s}_E + \\beta G^{\\rm s}_M$. The dependence of the results on the parameters of the model and the treatment of the Yukawa asymptotic behavior of the soliton are investigated.

Antonio Silva; Hyun-Chul Kim; Klaus Goeke
2004-11-30

248

Relativistic Thermal Bremsstrahlung Gaunt Factor for the Intracluster Plasma. II. Heavy Elements

  Astrophysics (arXiv)

Summary: We calculate the relativistic thermal bremsstrahlung Gaunt factor for the high-temperature plasma which exists in clusters of galaxies. We calculate the Gaunt factor by employing the Bethe-Heitler cross section corrected by the Elwert factor. The calculations in this paper are made for the fully ionized plasma for the following cases: Z = 10 (Ne), 12 (Mg), 14 (Si), 16 (S), 26 (Fe). We also calculate the Gaunt factor by using the Coulomb-distorted wave functions for nonrelativistic electrons following the method of Karzas and Latter. By comparing the Gaunt factors calculated by these two different methods, we carefully assess the accuracy of the calculation. We present the numerical results in the form of tables.

Satoshi Nozawa; Naoki Itoh; Yasuharu Kohyama
1998-04-21

249

HEMATOPOIESIS Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

  CiteSeer

Summary: The hematopoietic growth factor erythropoietin (Epo) triggers changes in the expression of genes that encode important regulators of erythroid cell growth and differentiation. We now report that Epo markedly upregulates chop (gadd153) expression and that this transcription factor plays a role in erythropoiesis. Using a differential hybridization assay, we isolated a full-length cDNA of chop as an Epo upregulated gene in Rauscher murine erythroleukemia cells. RNase protection assays demonstrated that Epo or dimethyl sulfoxide induction increased steady-state mRNA levels 10to 20-fold after 24 to 48 hours. Western blot analysis confirmed a marked increase in CHOP protein. Among the other c/ebp family members, only c/ebp ? was also upregulated during erythroid differentiation. Among normal hematopoietic cells examined, steady-state mRNA levels were highest

Margaret Coutts; Kunyuan Cui; Kerry L. Davis; Joan Cleves Keutzer; Arthur J. Sytkowski

250

www.mdpi.com/journal/ijms Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster

  CiteSeer

Summary: Abstract: Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. Several examples argue that FGF signalling is used in multi-step morphogenetic processes to achieve and maintain a transitional state of the cells required for the control of cell fate. In the genetic model Drosophila melanogaster, FGF signalling via the receptor tyrosine kinases Heartless (Htl) and Breathless (Btl) is particularly well studied. These FGF receptors affect gene expression, cell shape and cell–cell interactions during mesoderm layer formation, caudal visceral muscle (CVM) formation, tracheal morphogenesis and glia differentiation. Here, we will address the current knowledge of the biological functions of FGF signalling in the fly on the tissue, at a cellular and molecular level.

Villö Muha; Hans-arno J. Müller
2013-01-01

251

Plasma Membrane Phospholipid Scramblase 1 Is Enriched in Lipid Rafts and Interacts with the Epidermal Growth Factor Receptor

  Biology and Medicine Websites

Summary: with the Epidermal Growth Factor Receptor Jun Sun, Meera Nanjundan, Linda J. Pike,§ Therese Wiedmer, and Peter J-phosphorylation of PLSCR1, peaking at 5 min. Although PLSCR1 is a known substrate of c-Abl [Sun, J., et al. (2001) J. Biol that is important in the recognition and phagocytic clearance of injured, aged, or apoptotic cells (6-9). Although

Pike, Linda J.

252

The Maize CR4 Receptor-Like Kinase Mediates a Growth Factor-Like Differentiation Response

  Biotechnology Websites

Summary: for a differentiation response that is specifically programmed in the responding cells. Plant hormones such as auxin. For example, high auxin to cyto- kinin ratios inhibit lateral branch growth in the shoot but promote lateral

Becraft, Philip W.

253

Unidentified growth factors for turkey poults maintained on a synthetic diet

  Texas A&M University - TxSpace

Summary: copper sulfate. 24 TABLE 2 EFFECT OF EXTRACTION OF THE SOYBEAN PROTEIN AVD AMINO ACID SUPPLZKKNTATION ON POULT GROWTH TO 4 WEEKS 01' AGZ Ex eriment 1 Diet and. Supplements Average Weight at 4 weeks (grams) Response Over Basal Unextracted...

Salama, Fathi Mahmoud
1956-01-01

254

Prognostic value of vascular endothelial growth factor in breast cancer. Oncologist 5 Suppl

  CiteSeer

Summary: Angiogenesis, the process leading to the formation of new blood vessels from a preexisting vascular network, is necessary for tumor growth, invasion, and metastasis. Data from experimental and clinical studies indicate that breast carcinoma is an angiogenesisdependent tumor. Most retrospective

Giampietro Gasparini

255

II_{\\infty} Factors and M-theory in Asymptotically Flat Space-Time

  HEP - Theory (arXiv)

Summary: I discuss a formulation of M-theory at null infinity, which is based on general principles of holographic space-time, and is manifestly covariant. The construction utilizes a certain Type II Von Neumann algebra, which provides a kinematic framework, alternative to Fock Space, for describing the scattering states of eleven dimensional asymptotically flat M-theory. The construction provides a greatly clarified statement of the connection between SUSY and holography. I make preliminary remarks about dynamical equations for the S-matrix, and compactifications.

T. Banks
2006-07-03

256

The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the

  Biology and Medicine Websites

Summary: configuration through the interaction of loops or arms that extend from the backs of subdomains II and IV (11 of a back- to-back EGF receptor dimer (12, 13). Analyses of the binding of 125 I-EGF to its receptor have invariably resulted in concave up Scatchard plots that have been interpreted as indicating the presence

Pike, Linda J.

257

Clumping factors of HII, HeII and HeIII

  CERN Preprints

Summary: Estimating the intergalactic medium ionization level of a region needs proper treatment of the reionization process for a large representative volume of the universe. The clumping factor, a parameter which accounts for the effect of recombinations in unresolved, small-scale structures, aids in achieving the required accuracy for the reionization history even in simulations with low spatial resolution. In this paper, we study for the first time the redshift evolution of clumping factors of different ionized species of H and He in a small but very high resolution simulation of the reionization process. We investigate the dependence of the value and redshift evolution of clumping factors on their definition, the ionization level of the gas, the grid resolution, box size and mean dimensionless density of the simulations.

Jeeson-Daniel, Akila; Graziani, Luca
2014-01-01

258

High resolution spectroscopy for Cepheids distance determination. II. A period- projection factor relation

  Astrophysics (arXiv)

Summary: The projection factor is a key quantity for the interferometric Baade-Wesselink (hereafter IBW) and surface-brightness (hereafter SB) methods of determining the distance of Cepheids. Indeed, it allows a consistent combination of angular and linear diameters of the star. We aim to determine consistent projection factors that include the dynamical structure of the Cepheids' atmosphere. Methods. Hydrodynamical models of delta Cep and l Car have been used to validate a spectroscopic method of determining the projection factor. This method, based on the amplitude of the radial velocity curve, is applied to eight stars observed with the HARPS spectrometer. The projection factor is divided into three sub-concepts : (1) a geometrical effect, (2) the velocity gradient within the atmosphere, and (3) the relative motion of the "optical" pulsating photosphere compared to the corresponding mass elements (hereafter fo-g). Both, (1) and (3) are deduced from geometrical and hydrodynamical models, respectively, while (2) is derived directly from observations. The Fe I 4896.439 A line is found to be the best one to use in the context of IBW and SB methods. A coherent and consistent period-projection factor relation (hereafter Pp relation) is derived for this specific spectral line: p = [0.064 +- 0.020] log P + [1.376 +- 0.023]. This procedure is then extended to derive dynamic projection factors for any spectral line of any Cepheid. This Pp relation is an important tool for removing bias in the calibration of the period-luminosity relation of Cepheids. Moreover, it reveals a new physical quantity fo-g to investigate in the near future.

N. Nardetto; D. Mourard; Ph. Mathias; A. Fokin; D. Gillet
2008-04-08

259

Molecular line intensities as measures of cloud masses - II. Conversion factors for specific galaxy types

  Astrophysics (arXiv)

Summary: We present theoretically-established values of the CO-to-H2 and C-to-H2 conversion factors that may be used to estimate the gas masses of external galaxies. We consider four distinct galaxy types, represented by M51, NGC 6946, M82 and SMC N27. The physical parameters that best represent the conditions within the molecular clouds in each of the galaxy types are estimated using a chi^2 analysis of several observed atomic fine structure and CO rotational lines. This analysis is explored over a wide range of density, radiation field, extinction, and other relevant parameters. Using these estimated physical conditions in methods that we have previously established, CO-to-H2 conversion factors are then computed for CO transitions up to J=9-8. For the conventional CO(1-0) transition, the computed conversion factor varies significantly below and above the canonical value for the Milky Way in the four galaxy types considered. Since atomic carbon emission is now frequently used as a probe of external galaxies, we also present, for the first time, the C-to-H2 conversion factor for this emission in the four galaxy types considered.

T. A. Bell; S. Viti; D. A. Williams
2007-04-19

260

Genetic and environmental factors affecting growth characters of Charolais cattle in Southeastern Brazil

  Texas A&M University - TxSpace

Summary: . The results were reported for 1274 observations in the birth to weaning data, and 488 and 551 observations in the bull and heifer postnatal (birth to 24 months of age) data, respectively . Growth characters considered in this study were: birth weight... (BIRTH), 205-day weight (BW205), preweaning (birth to 205 days of age) absolute (BWAGR) and relative (BWRGR) growth rates, 365-day ( BW365 ), 455-day ( BW455 ), 550-day ( BW550 ), 640-day ( BW640 ) and 730-day (BW730) weights, postweaning (205 to 730...

Barbosa, Pedro Franklin
1982-01-01

261

GEOGRAPHICAL FEATURES VS. INSTITUTIONAL FACTORS: NEW PERSPECTIVES ON THE GROWTH OF

  Physics Websites

Summary: to the institution/geography debate on the explanation of growth and development. In particular, our methodology. The geography hypothesis declares that "the role of geography and resource endowments in development shouldn and Temple, 2005). The geography hypothesis advances two issues. Firstly, diseases could block long

Paris-Sud XI, Université de

262

The Turkey Transcription Factor Pit-1/GHF-1 Can Activate the Turkey Prolactin and Growth Hormone

  Biology and Medicine Websites

Summary: -0306; and Germplasm and Gamete Physiology Laboratory, Agricultural Research Service, U.S. Department of Agriculture plays in regulating the prolactin and growth hormone genes in avian species was examined- 1­Pit-1 interactions (Ingraham et al., 1990). The avian and teleostean Pit-1 proteins differ from

Ramachandran, Ramesh

263

ORIGINAL ARTICLE The a-receptor for platelet-derived growth factor as a target

  Biology and Medicine Websites

Summary: -mediated inhibition of skeletal metastases from prostate cancer cells MR Russell1,4 , WL Jamieson1,4 , NG Dolloff 1 of prostate cancer cells disseminated to the skeleton (Mundy, 2002). Using a mouse model of experimental. This is the first evidence that survival and growth of disseminated prostate cancer cells immediately after

Fatatis, Alessandro

264

Growth as affected by general hormonal factors and hormonal balances, and the limitations of such studies

  Physics Websites

Summary: excision. #12;Pituitary gland and its hormones. The effects of hypophysectomy vary with breed and age are reviewed with special emphasis on the role of the pituitary and its hormones (growth hormone, prolactin the effects of all the hormones, their role was first evi- denced by many experiments on endocrine gland

Paris-Sud XI, Université de

265

One-loop leading logarithms in electroweak radiative corrections: II. Factorization of collinear singularities

  HEP - Phenomenology (arXiv)

Summary: We discuss the evaluation of the collinear single-logarithmic contributions to virtual electroweak corrections at high energies. More precisely, we proof the factorization of the mass singularities originating from loop diagrams involving collinear virtual gauge bosons coupled to external legs. We discuss, in particular, processes involving external longitudinal gauge bosons, which are treated using the Goldstone-boson equivalence theorem. The proof of factorization is performed within the 't Hooft--Feynman gauge at one-loop order and applies to arbitrary electroweak processes that are not mass-suppressed at high energies. As basic ingredient we use Ward identities for Green functions with arbitrary external particles involving a gauge boson collinear to one of these. The Ward identities are derived from the BRS invariance of the spontaneously broken electroweak gauge theory.

Ansgar Denner; Stefano Pozzorini
2001-04-12

266

An Importance Sampling Scheme on Dual Factor Graphs. II. Models with Strong Couplings

  CERN Preprints

Summary: We consider the problem of estimating the partition function of the two-dimensional ferromagnetic Ising model in an external magnetic field. The estimation is done via importance sampling in the dual of the Forney factor graph representing the model. We present importance sampling schemes that can efficiently compute an estimate of the partition function in a wide range of model parameters. Emphasis is on models in which a subset of the coupling parameters is strong.

Molkaraie, Mehdi
2014-01-01

267

Form factors in finite volume II:disconnected terms and finite temperature correlators

  HEP - Lattice (arXiv)

Summary: Continuing the investigation started in a previous work, we consider form factors of integrable quantum field theories in finite volume, extending our investigation to matrix elements with disconnected pieces. Numerical verification of our results is provided by truncated conformal space approach. Such matrix elements are important in computing finite temperature correlation functions, and we give a new method for generating a low temperature expansion, which we test for the one-point function up to third order.

B. Pozsgay; G. Takacs
2007-06-25

268

Soft processes at the LHC, II: Soft-hard factorization breaking and gap survival

  HEP - Phenomenology (arXiv)

Summary: We calculate the probability that the rapidity gaps in diffractive processes survive both eikonal and enhanced rescattering. We present arguments that enhanced rescattering, which violates soft-hard factorization, is not very strong. Accounting for NLO effects, there is no reason to expect that the black disc regime is reached at the LHC. We discuss the predictions for the survival of the rapidity gaps for exclusive Higgs production at the LHC.

M. G. Ryskin; A. D. Martin; V. A. Khoze
2009-01-19

269

Chem 390 Physical Chemistry II Spring 2007 Boltzmann factors and partition functions revisited

  Chemistry Websites

Summary: of finding the system in the quantum state with energy Ej is proportional to the Boltzmann factor pj e-Ej /kBT e-Ej (1) where kB is Boltzmann's constant, and we have defined the useful combination 1/kBT. Each-Ej /kBT , (3) so that the properly normalized probabilities pj are [McQ&S, eq. (17.13)] pj = e-Ej Q = e


270

Molecular line intensities as measures of cloud masses - II. Conversion factors for specific galaxy types

  CERN Preprints

Summary: We present theoretically-established values of the CO-to-H2 and C-to-H2 conversion factors that may be used to estimate the gas masses of external galaxies. We consider four distinct galaxy types, represented by M51, NGC 6946, M82 and SMC N27. The physical parameters that best represent the conditions within the molecular clouds in each of the galaxy types are estimated using a chi^2 analysis of several observed atomic fine structure and CO rotational lines. This analysis is explored over a wide range of density, radiation field, extinction, and other relevant parameters. Using these estimated physical conditions in methods that we have previously established, CO-to-H2 conversion factors are then computed for CO transitions up to J=9-8. For the conventional CO(1-0) transition, the computed conversion factor varies significantly below and above the canonical value for the Milky Way in the four galaxy types considered. Since atomic carbon emission is now frequently used as a probe of external galaxies, we also ...

Bell, T A; Williams, D A
2007-01-01

271

Technological efficiency, technological change and total factor productivity growth in Chinese state-owned enterprises in the early 1990s

  CiteSeer

Summary: Based on a framework proposed by Battese and Coelli (1995), we estimated the stochastic frontier production function for four Chinese industries: building materials, chemicals, machinery and textiles during 1990–1994. The type of technological change is tested and total factor productivity (TFP) growth is calculated for each industry. We found no evidence of technological change in the building materials, chemicals and textiles industries and a neutral technological progress in the machinery industry. There was significant reduction of technical efficiency in the chemicals, machinery and textiles industries. As the result, chemicals and textiles experienced a negative TFP growth, whereas building materials and machinery display negligible TFP change. Our result cast doubt on the industrial reform measures in China. I.

Xiang Kong; Robert E. Marks; Guang Hua Wan
1999-01-01

272

Differentiating effects of somatomedin-C/insulin-like growth factor I and insulin on Leydig

  Computer Technologies and Information Sciences Websites

Summary: . Using an in vitro system of pig Leydig cells (LC) and Sertoli cells (SC) we have demonstrated that: 1 indicate that in addition to this endocrine regulation, other hormones and factors, coming from the blood

Boyer, Edmond

273

Insulin-like Growth Factor-I and Slow, Bi-directional Perfusion Enhance the Formation of Tissue-Engineered Cardiac Grafts

  MIT - DSpace

Summary: Biochemical and mechanical signals enabling cardiac regeneration can be elucidated using in vitro tissue-engineering models. We hypothesized that insulin-like growth factor-I (IGF) and slow, bi-directional perfusion could ...

Cheng, Mingyu

274

Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography

  MIT - DSpace

Summary: A critical method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses ...

Branchini, Lauren

275

Quantitative analysis of 2D and 3D models for epidermal growth factor receptor-dependent cell migration in the context of the extracellular microenvironment

  MIT - DSpace

Summary: Major therapeutic efforts have been devoted to targeting the epidermal growth factor receptor (EGFR), which is aberrantly expressed in many cancers and is correlated with tumor progression and invasiveness. In the current ...

Kim, Hyung-Do, Ph. D. Massachusetts Institute of Technology
2009-01-01

276

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

  MIT - DSpace

Summary: Epidermal growth factor receptor (EGFR)-mediated signaling helps regulate bone development and healing through its effects on osteogenic cells. Here, we show how EGFR activity and osteogenic differentiation responses in ...

Platt, Manu O.

277

Jump-Diffusion Risk-Sensitive Asset Management II: Jump-Diffusion Factor Model

  CERN Preprints

Summary: In this article we extend earlier work on the jump-diffusion risk-sensitive asset management problem [SIAM J. Fin. Math. (2011) 22-54] by allowing jumps in both the factor process and the asset prices, as well as stochastic volatility and investment constraints. In this case, the HJB equation is a partial integro-differential equation (PIDE). By combining viscosity solutions with a change of notation, a policy improvement argument and classical results on parabolic PDEs we prove that the HJB PIDE admits a unique smooth solution. A verification theorem concludes the resolution of this problem.

Davis, Mark
2011-01-01

278

Establishment of a Common European Economic Area as a Factor of Russia's Sustainable Growth

  CiteSeer

Summary: The idea of integration between the European Union and Russia within a "Common European Economic Area " is now at the top of the agenda in the dialogue between the EU and Russia. This confirms the fact that the EU considers Russia as a strategic partner. What this Common European Economic Area (CEEA) could be remains largely to be defined. This paper aims to argue that the CEEA is not only a positive development for the economic growth of Russia, but that it is a condition for the country’s sustainable growth and productivity increase. The paper then discusses the options for defining the CEEA in the most relevant way for Russia and the main conditions for succeeding in this strategy.

Ivan Samson; Jel Classification E

279

Receptor-mediated endocytosis of epidermal growth factor by hepatocyte in the perfused rat liver: ligand and receptor dynamics

  CiteSeer

Summary: Abstract. Substantial amounts of epidermal growth factor (EGF) are cleared from the circulation by hepatocytes via receptor-mediated endocytosis and subsequently degraded within lysosomes. We have used a combined biochemical and morphological approach to examine the fate of the receptor after exposure to EGF. Polyclonal antibodies were prepared against the purified receptor and their specificity established by immunoprecipitation and immunoblotting techniques. The EGF receptor was then localized by immunofluorescence and immunoperoxidase techniques and quantified on immunoblots. In untreated livers, EGF receptor was restricted to the sinusoidal and lateral surfaces of hepatocytes. 2-4 min after exposure of cells to EGF, the receptor was found in small vesicles

William A. Dunn; Timothy P. Connolly; Ann L. Hubbard
1984-01-01

280

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

  CiteSeer

Summary: Abstract. The time course of molecular events that accompany degeneration and death after nerve growth factor (NGF) deprivation and neuroprotection by NGF and other agents was examined in cultures of NGFdependent neonatal rat sympathetic neurons and compared to death by apoptosis. Within 12 h after onset of NGF deprivation, glucose uptake, protein synthesis, and RNA synthesis fell precipitously followed by a moderate decrease of mitochondrial function. The molecular mechanisms underlying the NGF deprivation-induced decrease of protein synthesis and neuronal death were compared and found to be different, demonstrating that this decrease of protein synthesis is insufficient to cause death subsequently. After these early changes and during the onset of neuronal atrophy,

Thomas L. Deckwerth; Eugene M. Johnson
1993-01-01

281

Modeling CO Emission: II. The Physical Characteristics that Determine the X factor in Galactic Molecular Clouds

  CERN Preprints

Summary: We investigate how the X factor, the ratio of H_2 column density (NH2) to velocity-integrated CO intensity (W), is determined by the physical properties of gas in model molecular clouds (MCs). We perform radiative transfer calculations on chemical-MHD models to compute X. Using integrated NH2 and W reproduces the limited range in X found in observations, resulting in a mean value X=2\\times10^20 s/cm^2/K^1/km^1 from the Galactic MC model. However, in limited velocity intervals, X can take on a much larger range due to CO line saturation. Thus, X strongly depends on both the range in gas velocities and volume densities. The temperature (T) variations within individual MCs do not strongly affect X, as dense gas contributes most to setting X. For fixed velocity and density structure, gas with higher T has higher W, yielding X ~ T^-1/2 for T~20-100 K. We demonstrate that the linewidth-size scaling relation does not influence the X factor - only the range in velocities is important. Clouds with larger linewidths, r...

Shetty, Rahul; Dullemond, Cornelis P; Ostriker, Eve C; Harris, Andrew I; Klessen, Ralf S
2011-01-01

282

Relativistic Thermal Bremsstrahlung Gaunt Factor for the Intracluster Plasma. II. Analytic Fitting Formulae

  Astrophysics (arXiv)

Summary: We present accurate analytic fitting formulae which summarize the results of the recent calculation by Nozawa, Itoh and Kohyama on the relativistic thermal bremsstrahlung Gaunt factor for the intracluster plasma. The fitting is carried out for Z = 1 to 28, 6.0 < log T < 8.5, -4.0 < log (omega/kT) < 1.0, where Z is the charge number of the ion, T is the temperature, and omega is the angular frequency of the emitted photon. The present analytic fitting formulae will be useful for the analysis of the X-ray emission which comes from the intracluster plasma as well as the other X-ray sources.

Naoki Itoh; Tsuyoshi Sakamoto; Shugo Kusano; Satoshi Nozawa; Yasuharu Kohyama
2007-07-31

283

Uterine Leiomyoma Risk. II. Atherogenic Factors and Uterine Irritation Faerstein et al. Risk Factors for Uterine Leiomyoma: A Practice-based Case-Control Study. II. Atherogenic Risk Factors and Potential Sources of Uterine Irritation

  CiteSeer

Summary: In this case-control study, the authors analyzed associations of uterine leiomyoma with atherogenic risk factors and potential sources of uterine irritation. The study included 318 case women with uterine leiomyoma that was first confirmed between 1990 and 1993 in the Baltimore, Maryland, area and

Eduardo Faerstein; Moyses Szklo; Neil B. Rosenshein

284

Engineering of the Heparin-Binding Domain of Neurotrophin-6 onto Nerve Growth Factor

  Biology and Medicine Websites

Summary: variable region III reverse turn of NGF with 31 residues from the NT-6 heparin-binding domain. Introduction derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). Their biological TrkA, BDNF and neurotrophin-4 (NT-4) bind TrkB and neurotrophin-3 (NT-3) preferentially binds Trk

Ibáñez, Carlos

285

On Optimal Growth Models when the Discount Factor is near 1 or equal to 1

  Physics Websites

Summary: in the policy function g. The CERMSEM, EP 1737 du CNRS, Universit´e de Paris I, Maison des Sciences Economiques one. We show that the value function and the policy function are continuous with respect both to the discount factor and the initial stock of capital x0. We prove that the optimal policy g(x0

Paris-Sud XI, Université de

286

Original article Effects of gas atmosphere, platelet-derived growth factor

  Computer Technologies and Information Sciences Websites

Summary: factor on cell numbers of rabbit embryos cultured in a protein-free medium JR Giles RH Foote Department, 1987; Carney and Foote, 1991). Although the majority of rabbit embryos cultured in these defined media and Foote, 1990, 1991; Col- las et al, 1991; Giles and Foote, 1995), indi- cating that the culture systems

Boyer, Edmond

287

Detection of growth factor binding to gelatin and heparin using a photonic crystal optical biosensor

  Engineering Websites

Summary: factor (rhTGF)-1 and bone morphogenetic protein (rhBMP)-2 with the two types of gelatin and heparin were interactions (basic gelatin with bone morphogenetic protein (BMP)-2 [7,9]). Protein­gelatin interactions: heparinNacidic gelatinNbasic gelatin. RhBMP-2 bound to the substrates but with less intensity than TGF-1

Cunningham, Brian

288

Optimal experimental design in an epidermal growth factor receptor signalling and down-regulation model

  Materials Science Websites

Summary: , the guanine exchange factor (GEF), Cool-1 (b-Pix) and the Rho family G protein Cdc42. The complex has been in Fig. 1. In particular, we examine the roles of the GEF, Cool-1 and the GTPase, Cdc42, that have down-regulation. The first mechanism involves the formation of a complex between active Cool-1, active

Myers, Chris

289

Direct Numerical Simulation of Reionization II: Recombinations, Clumping Factors, and the Photon Budget for Reionization

  CERN Preprints

Summary: In this first of several application papers, we investigate the mechanics of reionization from stellar sources in high-z galaxies, the utility of various clumping factors on estimating the recombination time in the IGM, and the photon budget required to achieve reionization. We test the accuracy of the static and time-dependent models of Madau et al. as predictors of reionization completion/maintenance. We simulate a WMAP7 LCDM cosmological model in a 20 Mpc comoving cube with 800^3 uniform fluid cells and dark matter particles. By tuning our star formation to approximately match the observed star formation rate density and luminosity function, we created a fully coupled radiation-hydro realization of H reionization which begins to ionize at z~10 and completes at z~5.8. We find that roughly 2 ionizing photons per H atom are required to convert the neutral IGM to a highly ionized state, which supports the "photon starved" scenario discussed by Bolton & Haehnelt. The events during reionization that lead to ...

So, Geoffrey C; Reynolds, Daniel R; Harkness, Robert P
2013-01-01

290

Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. PLoS One

  CiteSeer

Summary: Background: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the risk of developing specific malaria clinical complications. Nevertheless, susceptibility to experimental CM in the mouse has been linked to host genes including Transforming Growth Factor Beta 2 (TGFB2) and Heme oxygenase-1 (HMOX1). Here, we tested whether those genes were governing the risk of progressing to CM in patients with severe malaria syndromes. Methodology/Principal Findings: We report that the clinical outcome of P. falciparum infection in a cohort of Angolan children (n = 430) correlated with nine TGFB2 SNPs that modify the risk of progression to CM as compared to other severe forms of malaria. This genetic effect was explained by two haplotypes harboring the CM-associated SNPs (Pcorrec. = 0.035 and 0.036). In addition, one HMOX1 haplotype composed of five CM-associated SNPs increased the risk of developing the CM syndrome (Pcorrec. = 0.002) and was under-transmitted to children with uncomplicated malaria (P = 0.036). Notably, the HMOX1-associated haplotype conferred increased HMOX1 mRNA expression in peripheral blood cells of CM patients (P = 0.012). Conclusions/Significance: These results represent the first report on CM genetic risk factors in Angolan children and

Maria Rosário Sambo; Maria Jesus Trovoada; Carla Benchimol; Vatúsia Quinhentos; Rute Velosa; Maria Isabel Marques; Nuno Sepúlveda; Taane G. Clark; Stefan Mustafa; Oswald Wagner; António Coutinho; Carlos Penha-gonçalves

291

Growth factors, matrices, and forces combine and control stem Dennis E. Discher1, David J. Mooney2, and Peter W. Zandstra3

  Biotechnology Websites

Summary: Growth factors, matrices, and forces combine and control stem cells Dennis E. Discher1, David J of Toronto, Toronto, ON M5S 3E1 Canada Abstract Stem cell fate is influenced by a number of factors and mechanical niche with complex and dynamic regulation that stem cells sense. Decellularized tissue matrices

Zandstra, Peter W.

292

To hear Professor Ritchie Lowry's personal history is to gain insight intoAmerican history itself -from World War II to the current recession -and to understand the growth of Boston College from a local campus to one with national

  Materials Science Websites

Summary: To hear Professor Ritchie Lowry's personal history is to gain insight intoAmerican history itself - from World War II to the current recession - and to understand the growth of Boston College from in the Pacific Theater during World War II, spent a year and a half working for an international company in Japan

Huang, Jianyu

293

and protein expression changes in human trabecular meshwork cells treated with transforming growth factor-beta. Invest Ophthalmol Vis Sci

  CiteSeer

Summary: PURPOSE. To determine the genomic and proteomic expression changes in human trabecular meshwork cells when they are treated with transforming growth factor (TGF)-?. METHODS. Human trabecular meshwork cells from five donors were cultured for 3 days with 1 ng/mL of either TGF-?1 or-?2. Changes in gene expression determined with gene microarrays and alterations in protein expression detected by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) were studied in these cells after the incubation. RESULTS. With both TGF-?s, there was a substantial upregulation of genes that were related to secreted proteins or extracellular matrix. This result was consistent with pathologic changes observed in disease and with experiments on perfused trabecular meshwork. Several of the gene changes suggest that

Xiujun Zhao; Keri E. Ramsey; Dietrich A. Stephan; Paul Russell

294

Transforming Growth Factor ß\\Induces Cachexia and Systemic Fibrosis without an Antitumor Effect in Nude Mice

  CiteSeer

Summary: up by liver, spleen, lungs, kidneys, and tumor tissue but not by the brain. At doses exceeding 2 jig/day, TGF-,01 induced a generalized interstitial fibrosis and a cachexia, which was not mediated by elevated serum levels of tumor necrosis factor a as determined by Western blot analysis and enzyme-linked immunosorbent assay. A total of 200,000 cells of the estrogen receptor-negative human breast cancer line MDA-MB-231, which had been shown to be maximally growth inhibited in vitro by 40 pM TGF-/31 and to have high-affinity receptors (9, 11, 12), were injected into the mammary fat pad of each nude mouse. The duration of treatment was 16 days with ten animals in the control group and five animals in the treated groups. The dose ranged from 1 to 4 ^g per animal daily. The treatment was started 24 h after the injection of the tumor cells. Tumor

Gerhard Zugmaier; Soonmyoung Paik; George Wilding; Et Al; Contact The Aacr Publications; Gerhard Zugmaier; Soonmyoung Paik; George Wilding; Cornelius Knabbe; Ruth Lupu; Bernd Deschauer; Susan Simpson; Robert B. Dickson

295

Expression of Epidermal Growth Factor in Suprabasal Cells of Stratified Squamous Epithelia: Implications for a Role in Differentiation

  CiteSeer

Summary: There is a disparity in the fact that epidermal growth factor (EGF) can stimulate proliferation of a wide variety of cells in vitro, yet sites of synthesis for this polypeptide in vivo are generally associated with nonproliferative or differentiated cell populations. Unlike other known mitogenic members of the EGF family of ligands, EGF derives from a large (Mr ‘1 30,000) protein that contains multiple EGF-like domains; some of these domains contain putative Ca2-binding sites. In the present study, the mouse vaginal epithelium was used as a prototype tissue to investigate expression of the EGF precursor by stratified squamous epithelia. Stratification and cornification in this tissue are estrogen dependent. In the fully differentiated epithelium, EGF precursor

Y. Sakai; K. Gray Nelson; S. Snedeker; N. Bossert; M. P. Walker; J. Mclachlan; R. P. Diaugustine

296

Fish growth and degree-days II: selecting a base temperature for an among-population study

  Environmental Sciences and Ecology Websites

Summary: the thermal limits of growth and near the thermal optimum (e.g., as a result of the annual temperature cycle of describing the thermal opportunity for growth and development and is becoming increasingly popular when in To and the thermal range among simulated populations. We then show the same relationships in an analysis of length

Venturelli, Paul

297

Research Article Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction

  CiteSeer

Summary: Copyright © 2012 Simona Cardaropoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE). We hypothesize that pregnancy tissues are the source of MIF overexpression in PE. MIF protein was studied in maternal sera, placental tissues, fetal membranes, and umbilical cord of 8 control and 20 PE pregnancies: 10 with normal fetal growth (PE-AGA) and 10 with fetal growth restriction (PE-FGR). MIF levels were significantly higher in PE-AGA membranes than in controls and PE-FGR. In PE-FGR, MIF cord concentrations were higher than in PE-AGA while MIF placental levels were lower than in controls. MIF maternal serum levels were higher in PE, compared to controls, and the difference was mainly due to PE-FGR samples. These data support MIF involvement in PE pathogenesis and suggest that different pregnancy tissues contribute to MIF production in PE with and without fetoplacental compromise. 1.

Simona Cardaropoli; Luana Paulesu; Roberta Romagnoli; Francesca Ietta; Daniela Marzioni; Mario Castellucci; Ro Rolfo; Elena Vasario; Ettore Piccoli; Tullia Todros

298

Mechanistic Studies of Palladium Thin Film Growth from Palladium(II) -Diketonates. 2. Kinetic Analysis of the

  Chemistry Websites

Summary: follows an apparent power rate law that is first order in Cu and first order in hfac coverage Analysis of the Transmetalation Reaction of Bis(hexafluoroacetylacetonato)palladium(II) on Copper Surfaces Wenbin Lin, Ralph G. Nuzzo,*,, and Gregory S. Girolami*, Contribution from the School of Chemical

Girolami, Gregory S.

299

Protein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling Induced 3T3-L1

  Biology and Medicine Websites

Summary: with inhibitors of phos- phatidylinositol 3-kinase, LY294002 or wortmannin, leads to the complete blockadeProtein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling the phosphatidylinositol 3-kinase-protein ki- nase B/Akt signal cascade. In 3T3-L1 preadipocytes, pro- tein kinase B/Akt 1

Tian, Weidong

300

Annals of Biomedical Engineering, Vol. 32, No. 5, May 2004 (2004) pp. 645663 A Reaction-Diffusion Model of Basic Fibroblast Growth Factor

  Engineering Websites

Summary: -Diffusion Model of Basic Fibroblast Growth Factor Interactions with Cell Surface Receptors RENEE J. FILION and is expressed in many cultured cell types including fibroblasts, endothelial cells, smooth muscle cells such as cancer, atherosclerosis, and heart and limb ischemia, as well as normal wound healing and tissue

Popel, Aleksander S.
2004-01-01

301

Growth Factors Wound Healing

  Mathematics Websites

Summary: with TGF- activity or signaling in genetically engineered mice, the researchers are mimicking of identified genetic polymorphisms linked to susceptibil- ity to diseases is steadily increasing in the wake with the avail- ability of tools for precise genetic modification enables a functional analysis of these disease

Schüler, Axel

302

Laboratory and in situ investigations of factors affecting the growth and survivorship of the Scyphozoan jellyfish Aurelia sp1

  University of California eScholarship Repository

Summary: climate change, overfishing, and introduction of artificialIntroduction Global population growth and climate change areClimate Change……………………………………………… 10 Eutrophication……………………………………………….. 11 Habitat Modification…………………………………………. 16 Species Introduction………………………………………

Cawood, Alison Michelle
2012-01-01

303

Fast remote but not extreme quantiles with multiple factors. Applications to Solvency II and Enterprise Risk Management

  Mathematics Websites

Summary: II relies on the notion of 1-year equity distribution. Given the complexity of asset-liability and Enterprise Risk Management Matthieu Chauvigny Milliman, Paris, 64 rue Pierre Charron, 75008 Paris, email For operational purposes, in Enterprise Risk Management or in insurance for example, it may be important

Maume-Deschamps, Véronique

304

Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts

  Biology and Medicine Websites

Summary: and defined by vascularized endometrial growths outside the uterus. Endometriosis is produced in cycling rats by autotransplanting pieces of uterus onto abdominal arteries where they develop into cysts. The surgery induces) IS A CONDITION in women of childbearing age defined by the presence of endometrial growths outside the uterus

Berkley, Karen J.

305

H: TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res

  CiteSeer

Summary: It has long been postulated that protein tyrosine phosphatases may act as tumor suppressors because of their ability to counteract the oncogenic actions of protein tyrosine kinases. Here we report the cloning and char acterization of a novel human protein tyrosine phosphatase, TEP1. TEP1 contains the protein tyrosine phosphatase signature motif, and we show that it possesses an intrinsic protein tyrosine phosphatase activity. TEP1 also shares extensive homology with tensm, a cytoskeletal protein localized to focal adhesions, and with auxilin, a protein involved in synaptic vesicle transport. Immunofluorescence studies show that TEP1 is a cytoplasmic protein. The abundance of TEP1 transcription is altered in many trans formed cells. In the transforming growth factor fl-sensitive cells, TEP1 expression is rapidly down-regulated by transforming growth factor @1, a cytokine shown to be involved in regulating cell adhesion and cell motility. We have also mapped the gene encoding TEP1 to chromosome 10q23, a

Da-ming Li; Hong Sun; Cancer Res; Contact The Aacr Publications; Da-ming Li; Hong Sun
1997-01-01

306

Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study

  Physics Websites

Summary: between vascular dementia and Alzheimer s disease has become blurred, partly because of similar associations of' cardiovascular disease and its risk factors with different types of dementia and lower to be risk factor for4 impaired cognition or dementia, , whereas others either show no association

Paris-Sud XI, Université de

307

Growth factor-induced mobilization of cardiac progenitor cells reduces the risk of arrhythmias, in a rat model of chronic myocardial infarction. PLoS One

  CiteSeer

Summary: Heart repair by stem cell treatment may involve life-threatening arrhythmias. Cardiac progenitor cells (CPCs) appear best suited for reconstituting lost myocardium without posing arrhythmic risks, being commissioned towards cardiac phenotype. In this study we tested the hypothesis that mobilization of CPCs through locally delivered Hepatocyte Growth Factor and Insulin-Like Growth Factor-1 to heal chronic myocardial infarction (MI), lowers the proneness to arrhythmias. We used 133 adult male Wistar rats either with one-month old MI and treated with growth factors (GFs, n = 60) or vehicle (V, n = 55), or sham operated (n = 18). In selected groups of animals, prior to and two weeks after GF/V delivery, we evaluated stress-induced ventricular arrhythmias by telemetry-ECG, cardiac mechanics by echocardiography, and ventricular excitability, conduction velocity and refractoriness by epicardial multiple-lead recording. Invasive hemodynamic measurements were performed before sacrifice and eventually the hearts were subjected to anatomical, morphometric, immunohistochemical, and molecular biology analyses. When compared with untreated MI, GFs decreased stress-induced arrhythmias and concurrently prolonged the effective refractory period (ERP) without affecting neither the duration of

Leonardo Bocchi; Monia Savi; Gallia Graiani; Stefano Rossi; Aldo Agnetti; Francesca Stillitano; Costanza Lagrasta; Silvana Baruffi; Roberta Berni; Caterina Frati; Mario Vassalle; Elisabetta Cerbai; Emilio Macchi; Donatella Stilli; Federico Quaini; Ezio Musso
2011-01-01

308

Vascular Endothelial Growth Factor (VEGF) and Platelet (PF-4) Factor 4 Inputs Modulate Human Microvascular Endothelial Signaling in a Three-Dimensional Matrix Migration Context

  MIT - DSpace

Summary: The process of angiogenesis is under complex regulation in adult organisms, particularly as it often occurs in an inflammatory post-wound environment. As such, there are many impacting factors that will regulate the ...

Hang, Ta-Chun

309

Stern, C.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In: Hepatocyte Growth Factor -Scatter Factor (HGF-SF) and the c-MET receptor. (ed. I.D. Goldberg and E. Rosen) Basel: Birkhauser Verlag. pp. 369-380.

  Biology and Medicine Websites

Summary: Stern, C.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In inducing molecule in vertebrate embryos? In: Hepatocyte Growth Factor - Scatter Factor (HGF- SF) and the c.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In: Hepatocyte Growth

Stern, Claudio
1993-01-01

310

Form-factors in the Baxter-Bazhanov-Stroganov model II: Ising model on the finite lattice

  Mathematical Physics (arXiv)

Summary: We continue our investigation of the Baxter-Bazhanov-Stroganov or \\tau^{(2)}-model using the method of separation of variables [nlin/0603028,arXiv:0708.4342]. In this paper we derive for the first time the factorized formula for form-factors of the Ising model on a finite lattice conjectured previously by A.Bugrij and O.Lisovyy in [arXiv:0708.3625,arXiv:0708.3643]. We also find the matrix elements of the spin operator for the finite quantum Ising chain in a transverse field.

G. von Gehlen; N. Iorgov; S. Pakuliak; V. Shadura; Yu. Tykhyy
2008-04-14

311

On the Assumption of Initial Factorization in the Master Equation for Weakly Coupled Systems II: Solvable Models

  Quantum Physics (arXiv)

Summary: We analyze some solvable models of a quantum mechanical system in interaction with a reservoir when the initial state is not factorized. We apply Nakajima-Zwanzig's projection method by choosing a reference state of the reservoir endowed with the mixing property. In van Hove's limit, the dynamics is described in terms of a master equation. We observe that Markovianity becomes a valid approximation for timescales that depend both on the form factors of the interaction and on the observables of the reservoir that can be measured.

K. Yuasa; S. Tasaki; P. Facchi; G. Kimura; H. Nakazato; I. Ohba; S. Pascazio
2006-08-17

312

Protein Engineering vol 1 no 5 pp 399-406, 1987 Solution conformations of human growth hormone releasing factor

  Biology and Medicine Websites

Summary: releasing factor: comparison of the restrained molecular dynamics and distance geometry methods for a system factor in trifluoroethanoJ have been determined by molecular dynamics and distance geometry methods simulations, the NOE data were not sufficient for global con- vergence to a unique three-dimensional geometry

Clore, G. Marius

313

Fast remote but not extreme quantiles with multiple factors. Applications to Solvency II and Enterprise Risk Management

  Mathematics Websites

Summary: to estimate remote (but not extreme) quantiles of some function f of some random vector. The call to f may be time- and resource-consuming so that one aims at reducing as much as possible the number of calls to f: quantile estimation, risk factors, Enterprise Risk Management, accelerated algorithm, Simulation


314

Abstract N is often cited as a limiting factor for sapling growth in northeastern USA forests. However, under

  Environmental Sciences and Ecology Websites

Summary: (Odocoileus virginianus L.). We con- ducted a field fertilization experiment to test the hypoth- esis that saplings increase stem tissue N when soil N availability is elevated. We fertilized saplings of nine tree) and black cherry (Prunus serotina), had significant increases in radial growth when fertilized under high


315

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

  MIT - DSpace

Summary: The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined ...

Rameseder, J.

316

Effects of Environmental Factors on Growth Curve Variation for Kids 6-10 Months Old of Sistani Goat

  CiteSeer

Summary: Abstract- The aim of this study was conducted to analyze the effect of sex, dam weight after kidding, weaning age and litter size on growth curve variations for kids 6-10 months old of Sistani goat. The data (81 records) were collected from the

Hossein Bazzi

317

Supersymmetry and the Atiyah-Singer Index Theorem II: The Scalar Curvature Factor in the Schr{\\" o}dinger Equation

  HEP - Theory (arXiv)

Summary: The quantization of the superclassical system used in the proof of the index theorem results in a factor of $\\hbar^{2}R/8 $ in the Hamiltonian. The path integral expression of the kernel is analyzed up to and including 2-loop order. The existence of the scalar curvature term is confirmed by comparing the linear term in the heat kernel expansion with the 2-loop order terms in the loop expansion.

Ali Mostafazadeh
1993-09-10

318

Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow

  MIT - DSpace

Summary: The current gold standard for bone graft material is autologous bone, which provides mechanical support, possesses factors that promote bone formation, and contains connective tissue progenitors (CTPs), a heterogeneous ...

Marcantonio, Nicholas A. (Nicholas Alexander)
2008-01-01

319

Direct visualization of the binding and internalization of ferritin conjugate of epidermal growth factor in human carcinoma cells A-431, Z Cell Biol

  CiteSeer

Summary: We have prepared a conjugate of epidermal growth factor (EGF) and ferritin that retains substantial binding affinity for cell receptors and is biologically active. Glutaraldehyde-activated EGF was covalently linked to ferritin to produce a conjugate that contained EGF and ferritin in a 1:1 molar ratio. The conjugate was separated from free ferritin by affinity chromatography using antibodies to EGF. Monolayers of human epithelioid carcinoma cells (A-431) were incubated with EGF:ferritin at 4 ~ and processed for transmission electron microscopy. Under these conditions, ~ 6 • 105 molecules of EGF:ferritin bound to the plasma membrane of each cell. In the presence of excess native EGF, the number of bound ferritin particles was reduced by 99%, indicating that EGF:ferritin binds specifically to cellular EGF receptors. At 37 ~ cell-bound EGF:ferritin rapidly redistributed in the plane of the plasma membrane to form small groups that were subsequently internalized into pinocytic vesicles. By 2.5 min at 37 ~ 32 % of the cell-bound EGF:ferritin was localized in vesicles. After 2.5 min, there was a decrease in the proportion of conjugate in vesicles with a concomitant accumulation of EGF:ferritin in multivesicular bodies. By 30 min, 84 % of the conjugate was located in structures morphologically identified as multivesicular bodies or lysosomes. These results are consistent with other morphological and biochemical studies utilizing I~I-EGF and fluorescein-conjugated EGF. KEY WORDS hormone receptors growth factor 9 endocytosis lysosomes Epidermal growth factor (EGF) ~ initiates a complex series of cellular events which ultimately


1979-01-01

320

Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus

  CiteSeer

Summary: Physical exercise increases brain activity through mechanisms not yet known. We now report that in rats, running induces uptake of blood insulin-like growth factor I (IGF-I) by specific groups of neurons throughout the brain. Neurons accumulating IGF-I show increased spontaneous firing and a protracted increase in sensitivity to afferent stimulation. Furthermore, systemic injection of IGF-I mimicked the effects of exercise in the brain. Thus, brain uptake of IGF-I after either intracarotid injection or after exercise elicited the same pattern of neuronal accumulation of IGF-I, an identical widespread increase in neuronal c-Fos, and a similar stimulation of hippocampal brainderived neurotrophic factor. When uptake of IGF-I by brain cells was blocked, the exercise-induced increase on c-Fos expression was also blocked. We conclude that serum IGF-I mediates activational effects of exercise in the brain. Thus, stimulation of

Eva Carro; Angel Nuñez; Svetlana Busiguina; Ignacio Torres-aleman
2001-01-01

321

Nutritional and environmental factors affecting germination, growth, and sporulation of Pithomyces chartarum (Berk. & Curt.) M. B. Ellis

  Texas A&M University - TxSpace

Summary: , growth, and sporulation. Three isolates were used in this research, two from Texas and one from New Zealand. Germination required air and moisture, and several germ tubes were able to form per spore within a few hours. Spores were able to germinate...- desmin (65). This fungus has caused economic losses to ranchers in New Zealand since 1908 when the disease was first described by J. A. Gi. lruth (21) a New Zealand veterinarian. The disease caused loss in weight of animals and skin lesions on the face...

Whitlock, Larry Lee
1972-01-01

322

Subcytotoxic H2O2 Stress Triggers a Release of Transforming Growth Factor-1, Which Induces Biomarkers of Cellular

  Biology and Medicine Websites

Summary: and overexpression of these four genes. Normal human diploid fibroblasts (HDFs)1 exposed to vari- ous types of noncytotoxic oxidative stress display a senescent- like phenotype coined "stress-induced premature senescence transcription factor (9, 10). Last, several genes overex- pressed in senescent HDFs, such as fibronectin

de Magalhães, João Pedro

323

Reactive Oxygen Species Mediate Met Receptor Transactivation by G Protein-coupled Receptors and the Epidermal Growth Factor

  Biology and Medicine Websites

Summary: in complex with the transcription factor TCF upon activation of the Wnt-signaling pathway. Independent of Wnt and the ¶IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 kinase-dependent phospho- rylation. Here, we demonstrate that in human hepato- cellular and pancreatic

Ullrich, Axel

324

Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway

  CiteSeer

Summary: ), the antiapoptotic protein Bcl-2 and the cytokine response modifier A (CrmA) in modulating Schwann cell death in vitro. Bcl-2 inhibited Schwann cell apoptosis induced by survival factor withdrawal, whereas CrmA did not. In contrast, Bcl-2-transfected Schwann cells were susceptible to apoptosis in

Merja Soilu-hänninen; Paul Ekert; Tamara Bucci; Daniel Syroid; Perry F. Bartlett; Trevor J. Kilpatrick
1999-01-01

325

Stromal Cell-Derived Factor-1/CXCL12 Contributes to MMTV-Wnt1 Tumor Growth Involving Gr1 + CD11b + Cells

  CiteSeer

Summary: Background: Histological examinations of MMTV-Wnt1 tumors reveal drastic differences in the tumor vasculature when compared to MMTV-Her2 tumors. However, these differences have not been formally described, nor have any angiogenic factors been implicated to be involved in the Wnt1 tumors. Methodology/Principal Findings: Here, we show that MMTV-Wnt1 tumors were more vascularized than MMTV-Her2 tumors, and this correlated with significantly higher expression of a CXC chemokine, stromal cell-derived factor-1 (SDF1/ CXCL12) but not with VEGFA. Isolation of various cell types from Wnt1 tumors revealed that SDF1 was produced by both tumor myoepithelial cells and stromal cells, whereas Her2 tumors lacked myoepithelial cells and contained significantly less stroma. The growth of Wnt1 tumors, but not Her2 tumors, was inhibited by a neutralizing antibody to SDF1, but not by neutralization of VEGFA. Anti-SDF1 treatment decreased the proportion of infiltrating Gr1 + myeloid cells in the Wnt1 tumors, which correlated with a decrease in the percentage of endothelial cells. The involvement of Gr1 + cells was evident from the retardation of Wnt1 tumor growth following in vivo depletion of these cells with an anti-Gr1-specific antibody. This degree of inhibition on Wnt1 tumor growth was comparable, but not additive, to the effect observed with anti-SDF1, indicative of overlapping mechanisms of inhibition. In contrast, Her2 tumors were not affected by the depletion of Gr1 + cells. Conclusions/Significance: We demonstrated that SDF1 is important for Wnt1, but not for HER2, in inducing murine

Bob Y. Liu; Irina Soloviev; Peter Chang; John Lee; Xiaodong Huang; Cuiling Zhong; Paul Polakis; Chie Sakanaka

326

Partner orbits and action differences on compact factors of the hyperbolic plane. II: Higher-order encounters

  Mathematical Physics (arXiv)

Summary: Physicists have argued that periodic orbit bunching leads to universal spectral fluctuations for chaotic quantum systems. To establish a more detailed mathematical understanding of this fact, it is first necessary to look more closely at the classical side of the problem and determine orbit pairs consisting of orbits which have similar actions. We specialize to the geodesic flow on compact factors of the hyperbolic plane as a classical chaotic system. The companion paper [14] proved the existence of a unique periodic partner orbit for a given periodic orbit with a small-angle self-crossing in configuration space that is a 2-encounter and derived an estimate for the action difference of the orbit pair. In this paper, we provide an inductive argument to deal with higher-order encounters: we prove that a given periodic orbit including an $L$-parallel encounter has $(L-1)!-1$ partner orbits; we construct partner orbits and give estimates for the action differences between orbit pairs.

Hien Minh Huynh
2015-03-06

327

Large-scale growth evolution in the Szekeres inhomogeneous cosmological models with comparison to growth data

  General Relativity & Quantum Cosmology (arXiv)

Summary: We use the Szekeres inhomogeneous cosmological models to study the growth of large-scale structure in the universe including nonzero spatial curvature and a cosmological constant. In particular, we use the Goode and Wainwright formulation, as in this form the models can be considered to represent exact nonlinear perturbations of an averaged background. We identify a density contrast in both classes I and II of the models, for which we derive growth evolution equations. By including Lambda, the time evolution of the density contrast as well as kinematic quantities can be tracked through the matter- and Lambda-dominated cosmic eras up to the present and into the future. In various models of class I and class II, the growth rate is found to be stronger than that of the LCDM cosmology, and it is suppressed at later times due to the presence of Lambda. We find that there are Szekeres models able to provide a growth history similar to that of LCDM while requiring less matter content and nonzero curvature, which speaks to the importance of including the effects of large-scale inhomogeneities in analyzing the growth of large-scale structure. Using data for the growth factor f from redshift space distortions and the Lyman-alpha forest, we obtain best fit parameters for class II models and compare their ability to match observations with LCDM. We find that there is negligible difference between best fit Szekeres models with no priors and those for LCDM, both including and excluding Lyman-alpha data. We also find that the growth index gamma parametrization cannot be applied in a simple way to the growth in Szekeres models, so a direct comparison of the function f to the data is performed. We conclude that the Szekeres models can provide an exact framework for the analysis of large-scale growth data that includes inhomogeneities and allows for different interpretations of observations. (abridged)

Austin Peel; Mustapha Ishak; M. A. Troxel
2012-12-11

328

JCB Report Fibroblast Growth Factor 2 Internal Ribosome Entry Site (IRES) Activity Ex Vivo and in Transgenic Mice Reveals a Stringent Tissue-specific Regulation

  CiteSeer

Summary: Abstract. Fibroblast growth factor 2 (FGF-2) is a powerful mitogen involved in proliferation, differentiation, and survival of various cells including neurons. FGF-2 expression is translationally regulated; in particular, the FGF-2 mRNA contains an internal ribosome entry site (IRES) allowing cap-independent translation. Here, we have analyzed FGF-2 IRES tissue specificity ex vivo and in vivo by using a dual luciferase bicistronic vector. This IRES was active in most transiently transfected human and nonhuman cell types, with a higher activity in p53 ?/ ? osteosarcoma and neuroblastoma cell lines. Transgenic mice were generated using bicistronic transgenes with FGF-2 IRES or encephalomyocarditis virus (EMCV) IRES. Measurements of luciferase activity revealed high FGF-2 IRES activity in 11-d-old embryos

Laurent Créancier; Dominique Morello; Pascale Mercier; Anne-catherine Prats

329

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system

  CiteSeer

Summary: Abstract. This study was conducted to determine how extraordinarily high numbers of epidermal growth factor receptors (EGF-R) affected the binding and internalization of EGF in the transformed cell line A431. I found that at low EGF concentrations, the kinetics of binding behaved as a nonsaturable, first-order process showing no evidence of multiple-affinity classes of receptors. However, EGF dissociation rates were strongly dependent on the degree of receptor occupancy in both intact cells and isolated membranes. This occupancy-dependent dissociation appears to be due to diffusion-limited binding. EGF-induced receptor internalization was rapid and first order when the absolute number of occupied receptors was below 4 x 103 min-~. However, at higher occupancies the specific

H. Steven Wiley
1988-01-01

330

Phospholipase C Release of Basic Fibroblast Growth Factor from Human Bone Marrow Cultures as a Biologically Active Complex with a Phosphatidylinositol-anchored Heparan

  CiteSeer

Summary: Abstract. Basic fibroblast growth factor (bFGF) is a potent mitogen for human bone marrow stromal cells and stimulates haematopoiesis in vitro. We report here that primary human bone marrow cultures contain bFGF and express heparin-like bFGF binding sites on the cell surface and in the extracellular matrix (ECM). bFGF bound predominantly to a 200-kD cell surface heparan sulfate proteoglycan (HSPG), which was also found in conditioned medium. bFGF was released from bone marrow cultures by incubation with phosphatidylinositol-specific phospholipase C (PI-PLC) and, less efficiently, by plasmin. Solubilized bFGF was found as a complex with the 20041) HSPG. The complex was biologically active as shown by its ability to stimulate plasminogen activator

Sulfate Proteoglycan; Georg Brunner; Janice Gabrilove; Daniel B. Rifkin; E. Lynette Wilson

331

doi:10.1155/2012/540791 Review Article Utility of Vascular Endothelial Growth Factor Inhibitors in the Treatment of Ovarian Cancer: From Concept to Application

  CiteSeer

Summary: Copyright © 2012 Afshin Amini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Despite recent advances in the management of ovarian cancer, it remains the most lethal gynecologic malignancy. Vascular endothelial growth factor (VEGF) has been shown to play a pivotal role in the progression of ovarian cancer leading to the eventual development of malignant ascites. On this basis, agents rendering VEGF ineffective by neutralizing VEGF (bevacizumab), blocking its receptors (aflibercept), or interfering with the postreceptor signaling pathways (sunitinib) provide us with the rational treatment options. These agents are generally used in combination with the standard chemotherapeutic drugs. Here, we discuss the basis of and the logic behind the use of these agents in the treatment of epithelial ovarian cancer, as well as their evaluation in different preclinical and clinical studies. 1.

Afshin Amini; Samar Masoumi Moghaddam; David L. Morris; Mohammad H. Pourgholami

332

Kinetic model of II-VI(001) semiconductor surfaces: Growth rates in atomic layer epitaxy T. Volkmann, M. Ahr, and M. Biehl

  Computer Technologies and Information Sciences Websites

Summary: -regulation of atomic layer epitaxy (ALE) and demonstrate how the interplay of the reservoir occupation with the surface kinetics results in two different regimes: at high the growth rate is limited to ¡£¢ ¤ layers per ALE. Comparing the temperature dependence of the ALE growth rate in our model with experimental results for Cd

Biehl, Michael

333

Water ice growth around evolved stars

  CERN Preprints

Summary: We present a model of the growth of water ice on silicate grains in the circumstellar envelopes of Asymptotic Giant Branch (AGB) stars and Red Super Giants. We consider the growth of ice by gas grain collisions, the thermal evaporation of ice from a grain, and sputtering. Our model contains several improvements compared to earlier models, including a detailed treatment of the effects of sputtering, a detailed calculation of the radiation pressure on the grain, and the treatment of subsonic drift velocities. In terms of drift velocity between the grains and gas in the envelope, we find that the ice formation process can be divided into three regimes: (i) a sputtering dominated regime where ice growth is heavily suppressed, (ii) an intermediate regime with moderately efficient condensation and (iii) a thermally dominated regime where ice formation is highly efficient. Sputtering is the critical factor which determines if ice formation can occur at all. We find that in Red Supergiants, ice formation is suppresse...

Dijkstra, C; Hoogzaad, S N; De Koter, A; Min, M
2003-01-01

334

Streit, A. and Stern, C.D. (1997). Competence for neural induction: HGF/SF, HGFl/MSP and their receptors c-met and Ron. In: Plasminogen-related growth factors. Ciba Fdn. Symp. 212,

  Biology and Medicine Websites

Summary: Streit, A. and Stern, C.D. (1997). Competence for neural induction: HGF/SF, HGFl. and Stern, C.D. (1997). Competence for neural induction: HGF/SF, HGFl/MSP and their receptors c-met and Ron. In: Plasminogen-related growth factors. Ciba Fdn. Symp. 212, 155-168. #12;Streit, A. and Stern, C

Stern, Claudio
1997-01-01

335

Inhibition of Hepatocyte DNA Synthesis by Transforming Growth Factor Cyclic AMP: Effect Immediately before the d/S Border1 and

  CiteSeer

Summary: Previous studies have shown that both transforming growth factor 0 (TGF-/3) and cyclic AMP (cAMP) inhibit hepatocyte DNA synthesis. While cAMP (in addition to being stimulatory in Go/early GO exerts its inhibition on hepatocytes late in (.,. the point where TGF-/3 inhibits has not been precisely defined. We have now examined further the inhibitory effects of cAMP and TGF-/3, on DNA synthesis in primary rat hepatocyte cultures and, in particular, tried to determine where in the prereplicative period the cells are sensitive to these agents. Although a transient exposure to TGF-/3, (but not glucagon) during the first hours of the cell culturing led to inhibition of DNA synthesis, the cells were more sensitive at a point late in (.,, where they also were inhibited by cAMP. Thus, exposure to TGF-/3,, glucagon, or the cAMP analogue 8-chlorophenylthio-cAMP at a time when there was a continuous recruitment of cells to S phase strongly decreased the rate of S-phase entry. For both TGF-/3

G. Hege Thoresen; Magne Refsnes; Thoralf Christoffersen; Cancer Res; Contact The Aacr Publications; G. Hege Thoresen; Magne Refsnes; Thoralf Christoffersen
2013-01-01

336

Nucleocytoplasmic transport is enhanced concomitant with nuclear accumulation of epidermal growth factor (EGF) binding activity in both 3T3-1 and EGF receptor reconstituted NR-6 fibroblasts.J. Cell Biol

  CiteSeer

Summary: Abstract. Measurements of nucleocytoplasmic transport of fluorescent-labeled macromolecules were performed in both an EGF-nonresponsive mutant fibroblast line (3T3-NR6) and in the same cell line reconstituted with active EGF receptors derived from rat hepatic membrane fraction. Immunolocalization studies of exogenously incorporated EGF receptors in reconstituted 3T3-NR6 fibroblasts demonstrated predominantly intracellular localization. The EGF receptor constructs also showed EGF-stimulated incorporation of [3H]thymidine, providing biochemical evidence for functional integration of the exogenously supplied EGF receptors into the reconstituted fibroblasts. Additional support for the functional incorporation of receptor may be inferred from the enhanced cellular accumulation of ~2SI-EGF in cells treated with chloroquine and leupeptin. ~25I-EGF binding and transnuclear macromolecular transport measurements in mutant and reconstituted cells, in conjunction with such measurements on nuclei isolated from these cells, provide data consistent with a growth factor/nuclear signaling mechanism dependent on the nuclear acquisition of EGF binding activity from the plasma membrane. p OLYPEPTIDE growth factors and hormones serve as regulatory molecules for cell differentiation and also as initiators of coordinated cellular responses to extracellular metabolic variation (15). Cell type-specific growth factor receptors in the plasma membrane of cells serve as the primary targets and ultimate discriminators for the large number of growth factors in the cellular environment (42, 43, 48). A question central to the mechanism of polypeptide growth factor signaling has been whether ligand-activated plasma membrane receptors (by themselves or in functional aggregates with other effector macromolecules [20, 22, 41]) produce a nuclear response uniquely as a result of either direct translocation to the nucleus (receptor translocation activation

Lian-wei Jiang; Melvin Schindler
1990-01-01

337

Molecular beam epitaxy growth and characterization of broken-gap ,,type II... superlattices and quantum wells for midwave-infrared laser diodes

  Physics Websites

Summary: type-II MWIR laser development work em- ployed multiple quantum well MQW samples with InAs/ GaInSb indepen- dently vary the thicknesses of the two constituent layers as well as the composition of the GaInSb, the suppression of AR and ISBA was some- what limited with the two-layer BGSL structure.4 Therefore the InAs/GaInSb

Flatte, Michael E.

338

FIRST-YEAR GROWTH OF THE WALLEYE, STIZOSZ-‘EDIO~ VITREUM VITREUM (MITCHILL), AND ASSOCIATED FACTORS IN THE RED LAKES, MINNESOTA’

  CiteSeer

Summary: First-year growth of the wallcyc, S&o&e&on vitreum vitreum ( Mitchill), was studied from 4,544 fish collcctcd during the first summer of lift in the Red Lakes in six seasons and from back calculations on 4,474 fish one year or more in age representing 17 year classes. Sexes did not differ in growth rate. Growth within the season varied greatly in different years and total growth deviatccl as much as 15.3 % from the mean of the cntirc period. Water tcmpcraturc, size of brood, and abundance of large walleyes and perch did not affect growth rate. Very early or late spawning influenced total growth during the season and final size and goodness or poorness of a season’s growth was determined by the middle of July. Growth rate of young-of-the-year perch and total use of perch as food did not signifi-cantly influence growth. Incidcncc of perch in walleye stomachs ranged from 10.9 to 98.0% and spottail shiner was a more important food item in most years than perch. Total first-year growth of the walleye was apparently clctcrmincd bcforc fish became a major item in the diet.

Lloyd L. Smith; Richard L. Pycha

339

Studies on the regulation of betanerve growth factor gene expression in the rat iris: the level of mRNAencoding nerve growth factor is increased in irises placed in explant cultures in vitro, but not in irises deprived of sensory or sympathetic innervatio

  CiteSeer

Summary: Abstract. Beta-nerve growth factor (NGF) is a protein necessary for the survival and maintenance of sympathetic and sensory neurons that appears to be produced by the target tissues of these neurons in vivo. Both denervation and the culture of explants of one model target, the rat iris, leads to an increase in the NGF content, suggesting that innervating neurons may regulate a step in synthesis or turnover of NGF. To determine whether there is a change in synthesis controlled at the mRNA level, the rat iris has been assayed for its content of NGF mRNA after surgical and chemical denervation and after explant into culture. Using a sensitive blot hybridization assay, a large, rapid increase in the content of NGF mRNA was observed upon explant of the rat iris. The increase was

David L. Shelton; Louis F. Reichardt
1986-01-01

340

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-?1-like molecule by plasmin during co-culture

  CiteSeer

Summary: Abstract. When a confluent monolayer of bovine aortic endothelial (BAE) cells is wounded with a razor blade, endothelial cells (ECs) spontaneously move into the denuded area. If bovine pericytes or smooth muscle cells (SMCs) are plated into the denuded area at low density, they block the movement of the ECs. This effect is dependent upon the number of cells plated into the wound area and contact between ECs and the plated cells. Antibodies to transforming growth factor-/31 (TGF-B1) abrogate the inhibition of BAE cell movement by pericytes or SMCs. TGF-/31, if added to wounded BAE cell monolayers, also inhibits cell movement. When cultured separately, BAE cells, pericytes, and SMCs each produce an inactive TGF-/31-like molecule which is activated in BAE cell-pericyte or BAE celI-SMC co-cultures. The activation appears to be mediated by plasmin as the inhibitory effect on cell movement in co-cultures of BAE cells and pericytes is blocked by the inclusion of inhibitors of plasmin in the culture medium. T HE organization of the cellular elements of the microvasculature is relatively simple since most capillaries and postcapillary venules consist only of endothelial cells (ECs) t and pericytes. In these vessels, the pericytes are located on the abluminal side of the ECs and appear to make direct contact with the ECs. In larger blood vessels, the two major cell types, the EC and the smooth muscle cell (SMC), are separated by the basal lamina which delineates the intima from the media. While there is some data available on the effects of in vivo interactions between ECs and SMCs (Reidy et al. 1982, 1983), there is increasing evidence that pericytes may be negative regulators of EC proliferation and neovascularization

Yasufumi Sato; Daniel B. Ritkin
1989-01-01

341

Multiwavelength study of massive galaxies at z~2. II. Widespread Compton thick AGN and the concurrent growth of black holes and bulges

  Astrophysics (arXiv)

Summary: Approximately 20-30% of 1.46.2 keV. The stacked X-ray spectrum rises steeply at >10 keV, suggesting that these sources host Compton-thick Active Galactic Nuclei (AGNs) with column densities N_H~10^{24} cm^-2 and an average, unobscured X-ray luminosity L_{2-8 keV}~(1-4)x10^43 erg/s. Their sky density(~3200 deg^-2) and space density (~2.6x10^-4 Mpc^-3) are twice those of X-ray detected AGNs at z~2, and much larger than those of previously-known Compton thick sources at similar redshifts. The mid-IR excess galaxies are part of the long sought-after population of distant heavily obscured AGNs predicted by synthesis models of the X-ray background. The fraction of mid-IR excess objects increases with galaxy mass, reaching ~50-60% for M~10^11 M_sun, an effect likely connected with downsizing in galaxy formation. The ratio of theinferred black hole growth rate from these Compton-thick sources to the global star formation rate at z=2 is similar to the mass ratio of black holes to stars inlocal spheroids, implying concurrent growth of both within the precursors oftoday's massive galaxies.

E. Daddi; D. M. Alexander; M. Dickinson; R. Gilli; A. Renzini; D. Elbaz; A. Cimatti; R. Chary; D. Frayer; F. E. Bauer; W. N. Brandt; M. Giavalisco; N. A. Grogin; M. Huynh; J. Kurk; M. Mignoli; G. Morrison; A. Pope; S. Ravindranath
2007-07-24

342

Aggregate and Sectoral TFP Growth in Turkey: A Growth Accounting Exercise

  Computer Technologies and Information Sciences Websites

Summary: : Growth accounting; total factor productivity; economic growth in Turkey JEL Classification: O40, O47 We performance. By contrast economic growth has been higher and more persistent in the last decade. The purpose and services. A growth accounting exercise allows us to decompose aggregate economic growth into growth

Yanikoglu, Berrin

343

Targeting insulin-like growth factor pathways University of Minnesota Cancer Center, Department of Medicine, MMC 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA

  Chemistry Websites

Summary: to insulin receptor (IR). The function for IR in health and disease is well known. IGF-IR plays an important role in childhood growth as demonstrated in both humans and mice (Liu et al, 1993; Abuzzahab et al), activation of IGF-IR requires binding to ligand in most physiologic settings. This important fact has

Cai, Long

344

The NPH4 locus encodes the auxin response factor ARF7, a conditional regulator of differential growth in aerial Arabidopsis tissue

  CiteSeer

Summary: . The phenotypes of nph4 mutants, which include multiple differential growth defects associated with reduced auxin responsiveness, including impaired auxin-induced gene expression, are consistent with the predicted loss of function of a transcriptional activator, and these phenotypes indicate that auxin

Reneé M. Harper; A Emily L. Stowe-evans; A Darron R. Luesse; Hideki Muto; B Kiyoshi Tatematsu; Masaaki K. Watahiki; Kotaro Yamamoto; Emmanuel Liscum A
2000-01-01

345

Antagonistic functions of Tis11b and HuR in the hormonal regulation of vascular endothelial growth factor mRNA stability

  Physics Websites

Summary: Antagonistic functions of Tis11b and HuR in the hormonal regulation of vascular endothelial growth, regulation of VEGF expression by the pituitary hormone ACTH ensures the maintenance of the organ vasculature export of HuR is a rate-limiting step in this process. HuR appears to transiently stabilize VEGF

Paris-Sud XI, Université de

346

Epidermal growth factor-induced selective phosphorylation of cultured rat hepatocyte 55-kD cytokeratin before filament reorganization and DNA synthesis

  CiteSeer

Summary: Abstract. We have reported previously that the addition of dexamethasone to cultured quiescent suckling rat hepatocytes in the presence of insulin, a culture condition which does not cause growth activation, induces a selective increase in the synthesis of the 49kD/55-kD cytokeratin (CK49/CK55

Richard Blouin; Lise Bourgon
1989-01-01

347

eta and eta' in a coupled Schwinger-Dyson and Bethe-Salpeter approach. II. The gamma^* gamma transition form factors

  Nuclear Theory (arXiv)

Summary: The applications of the consistently coupled Schwinger-Dyson and Bethe-Salpeter approach to the eta-eta' complex are extended to the two-photon transition form factors of eta and eta' for spacelike transferred momenta. We compare our predictions with experiment and some other theoretical approaches.

Dalibor Kekez; Dubravko Klabucar
2002-04-11

348

Form factors in the massless coset models su(2)_k+1 \\otimes su(2)_k /su(2)_2k+1 - Part II

  Mathematical Physics (arXiv)

Summary: Massless flows from the coset model su(2)_k+1 \\otimes su(2)_k /su(2)_2k+1 to the minimal model M_k+2 are studied from the viewpoint of form factors. These flows include in particular the flow from the Tricritical Ising model to the Ising model. By analogy with the magnetization operator in the flow TIM -> IM, we construct all form factors of an operator that flows to \\Phi_1,2 in the IR. We make a numerical estimation of the difference of conformal weights between the UV and the IR thanks to the \\Delta-sum rule; the results are consistent with the conformal weight of the operator \\Phi_2,2 in the UV. By analogy with the energy operator in the flow TIM -> IM, we construct all form factors of an operator that flows to \\Phi_2,1. We propose to identify the operator in the UV with \\sigma_1\\Phi_1,2.

P. Grinza; B. Ponsot
2005-04-11

349

Cognitive Neuroscience Cognitive Neuroscience Methods II.

  Biology and Medicine Websites

Summary: of the Additive Factors Method · With the additive factors method, stages of processing can be inferred1 Cognitive Neuroscience PSYC 685 Cognitive Neuroscience Methods II. Raja Parasuraman Overview Information Processing Neuropsychology Computational Modeling ........all at the 101 level Information

Parasuraman, Raja

350

: (i) -, ; (ii) -

  Biology and Medicine Websites

Summary: . . () , . , . , . ­ ­ , . : , , , . , , , , , , . . , , , «» : (i) - , ; (ii) - , (van Doorn et al., 2011). 30- , . , . , , , . , (Galluzzi et al., 2012). , (van Doorn et al., 2011.) , ( , ) , . , , - (Bonneau et al., 2008), , , , ­ (Uren et al., 2000). , , , , . : (VPE

Kaplan, Alexander

351

Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by a platelet-derived growth factor receptor

  Biology and Medicine Websites

Summary: Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USA Prostate adenocarcinoma be the ability of bone- produced factors to specifically select disseminated prostate cancer cells

Meucci, Olimpia

352

A Structural Analysis of Chile's Long-Term Growth: History, Prospects and Policy Implications*

  Renewable Energy Websites

Summary: II.1 Climate Zone II.2 Scope of the Market II.3 Natural Resource Endowments II.4 Population, Culture of these Structural Features III. Chile's Long-Term Growth Record in International Comparison IV. Natural Resource and the Volatility of Export Earnings IV.4 Are Natural Resources a Hindrance to Growth? IV.5 A Brief Literature


353

Insulin Through the Ages: Phylogeny of a Growth Promoting and Metabolic Regulatory Hormone 1

  CiteSeer

Summary: SYNOPSIS. Insulin was discovered in 1922 as the causative factor for a human metabolic disorder (diabetes mellitus), but it was recognized early that the hormone had a broad phylogenetic distribution. By the mid 1970s, insulin had been isolated and sequenced from all classes of vertebrates, including Agnatha. Also it was discovered that the insulin gene family in vertebrates included two closely related hormones named insulin-like growth factor (IGF)-I and-II. More recently, the application of recombinant DNA techniques have identified insulin-like peptide genes in invertebrates, including insects, molluscs and nematode and these findings clearly establish that insulin is an evolutionarily ancient hormone which is present in all metazoa. Here we briefly review the structure and function of the insulin/ IGF gene family in vertebrates and invertebrates. Although these studies are ongoing, it appears that in invertebrates the insulin-like peptides function predominately as mitogenic growth factors that act to promote tissue growth and development. However, in vertebrates the mitogenic growth function has been subsumed by IGF-I and-II while insulin has acquired the function of being primarily a metabolic regulatory hormone. The gene duplication and divergence events necessary for this development probably occurred early during vertebrate evolution in the transition from protochordates, represented by extant amphioxus, to primitive jawless vertebrates, represented by extant lamprey and hagfish.

Shu Jin; Chan; Donald F. Steiner

354

doi:10.1155/2011/124256 Review Article Transforming Growth Factor-Beta Signaling in the Neural Stem Cell Niche: A Therapeutic Target for Huntington’s Disease

  CiteSeer

Summary: Copyright © 2011 Mahesh Kandasamy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The neural stem cell niches possess the regenerative capacity to generate new functional neurons in the adult brain, suggesting the possibility of endogenous neuronal replacement after injury or disease. Huntington disease (HD) is a neurodegenerative disease and characterized by neuronal loss in the basal ganglia, leading to motor, cognitive, and psychological disabilities. Apparently, in order to make use of the neural stem cell niche as a therapeutic concept for repair strategies in HD, it is important to understand the cellular and molecular composition of the neural stem cell niche under such neurodegenerative conditions. This paper mainly discusses the current knowledge on the regulation of the hippocampal neural stem cell niche in the adult brain and by which mechanism it might be compromised in the case of HD. 1. Adult Neurogenesis The renowned Spanish neuroanatomist Cajal stated that “Once development was ended, the founts of growth and regeneration of the axons and dendrites dried up irrevocably. In adult centers, the nerve paths are something

Mahesh K; Ralf Reilmann; Jürgen Winkler; Ulrich Bogdahn; Ludwig Aigner

355

Nukiwa T. Simultaneous or delayed administration of hepatocyte growth factor equally represses the fibrotic changes in murine lung injury induced by bleomycin: a morphologic study. Am J Respir Crit Care Med 1997;156:1937

  CiteSeer

Summary: Hepatocyte growth factor (HGF) is a humoral mediator of epithelial-mesenchymal interactions, acting on a variety of epithelial cells as mitogen, motogen, and morphogen. Exogenous HGF acts as a hepatotrophic factor and a renotrophic factor during experimental injury. To investigate whether HGF has a pulmotrophic function, human recombinant HGF was administered to C57BL/6 mice with severe lung injury by bleomycin (BLM). Low dose simultaneous and continuous administration of HGF (50 ?g/mouse/7 d) with BLM (100 mg/mouse/7 d) repressed fibrotic morphological changes at 2 and 4 wk. Ashcroft score showed a significant difference in lung fibrosis with and without HGF at 4 wk (3.7 ? 0.4 versus 4.9 ? 0.3, p ? 0.05). Furthermore, either simultaneous or delayed administration of high dose HGF (280 ?g/mouse/14 d) equally repressed fibrotic changes by BLM when examined at 4 wk (Ashcroft score: 2.6 ? 0.4 and 2.4 ? 0.2 versus 4.1 ? 0.2, p ? 0.01). Hydroxyproline content in the lungs was significantly lower in mice with either simultaneous or delayed administration of high dose HGF as compared to those administered BLM alone (121.8 ? 8.1 % and 113.2 ? 6.2% versus 162.7 ? 4.6%, p ? 0.001). These findings indicate that exogenous HGF acts as a pulmotrophic factor in vivo and prevents the progression of BLM-induced lung injury when administered in either a simultaneous or delayed fashion. HGF may be a potent candidate to prevent or treat lung fibrosis.

Masahiro Yaekashiwa; Shoichi Nakayama; Kazuya Ohnuma; Toshihiko Sakai; Tatsuya Abe; Ken Satoh; Kunio Matsumoto; Toshikazu Nakamura; Tohru Takahashi

356

Water ice growth around evolved stars

  Astrophysics (arXiv)

Summary: We present a model of the growth of water ice on silicate grains in the circumstellar envelopes of Asymptotic Giant Branch (AGB) stars and Red Super Giants. We consider the growth of ice by gas grain collisions, the thermal evaporation of ice from a grain, and sputtering. Our model contains several improvements compared to earlier models, including a detailed treatment of the effects of sputtering, a detailed calculation of the radiation pressure on the grain, and the treatment of subsonic drift velocities. In terms of drift velocity between the grains and gas in the envelope, we find that the ice formation process can be divided into three regimes: (i) a sputtering dominated regime where ice growth is heavily suppressed, (ii) an intermediate regime with moderately efficient condensation and (iii) a thermally dominated regime where ice formation is highly efficient. Sputtering is the critical factor which determines if ice formation can occur at all. We find that in Red Supergiants, ice formation is suppressed, while the winds of OH/IR stars allow for efficient condensation and can convert significant fractions of the available water vapor (tens of percent) into ice mantles on grains. Population II AGB stars hardly form ice due to their low dust to gas ratios. We also modify an analytical equation describing condensation and depletion (Jura and Morris, 1985) in order to give reasonable results for high and low drift velocities. Initially, ice will condense in crystalline form, but continuing condensation at low temperatures, and damage caused by interstellar UV photons favor the production of amorphous ice as well. We predict that a significant fraction of the ice formed will be amorphous.

C. Dijkstra; C. Dominik; S. N. Hoogzaad; A. de Koter; M. Min
2003-01-29

357

Human Skin Culture as an Ex Vivo Model for Assessing the Fibrotic Effects of Insulin-Like Growth Factor Binding Proteins

  CiteSeer

Summary: Abstract: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology. A hallmark of SSc is fibrosis of the skin and internal organs. We recently demonstrated increased expression of IGFBP-3 and IGFBP-5 in primary cultures of fibroblasts from the skin of patients with SSc. In vitro, IGFBP-3 and IGFBP-5 induced a fibrotic phenotype and IGFBP-5 triggered dermal fibrosis in mice. To assess the ability of IGFBPs to trigger fibrosis, we used an ex vivo human skin organ culture model. Our findings demonstrate that IGFBP-3 and IGFBP-5, but not IGFBP-4, increase dermal and collagen bundle thickness in human skin explants, resulting in substantial dermal fibrosis and thickening. These fibrotic effects were sustained for at least two weeks. Our findings demonstrate that human skin ex vivo is an appropriate model to assess the effects of fibrosis-inducing factors such as IGFBPs, and for evaluating the efficacy of inhibitors/therapies to halt the progression of fibrosis and potentially reverse it.

Hidekata Yasuoka; Adriana T. Larregina; Yukie Yamaguchi; Carol A. Feghali-bostwick

358

Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling

  CiteSeer

Summary: Oxidative stress kills neurons by stimulating FOXO3, a transcription factor whose activity is inhibited by insulin-like growth factor I (IGF-I), a wide-spectrum neurotrophic signal. Because recent evidence has shown that oxidative stress blocks neuroprotection by IGF-I, we examined whether attenuation of IGF-I signaling is linked to neuronal death by oxidative stress, as both events may contribute to neurodegeneration. We observed that in neurons, activation of FOXO3 by a burst of oxidative stress elicited by 50 ?M hydrogen peroxide (H 2O 2) recruited a two-pronged pathway. A first, rapid arm attenuated AKT inhibition of FOXO3 through p38 MAPK-mediated blockade of IGF-I stimulation of AKT. A second delayed arm involved activation of FOXO3 by Jun-kinase 2 (JNK2). Notably, blockade of IGF-I signaling through p38 MAPK was necessary for JNK2 to activate FOXO3, unveiling a competitive regulatory interplay between the two arms onto FOXO3 activity. Therefore, an abrupt rise in oxidative stress activates p38 MAPK to tilt the balance in a competitive AKT/JNK2 regulation of FOXO3 toward its activation, eventually leading to neuronal death. In view of previous observations linking attenuation of IGF-I signaling to other causes of neuronal death, these findings suggest that blockade of trophic input is a common step in neuronal death.

David Dávila; Ignacio Torres-aleman

359

1.5 Malthusian Growth

  Hopf Topology Archive

Summary: Feb 16, 2007 ... The simplest mathematical model of population growth is obtained by assuming ... account of the fact that as the population increases, several factors will begin to affect the ..... Use some form of technology to solve the pair of.

PRETEX (Halifax NS) #1 1054 1999 Mar 05 10:59:16
2010-01-20

360

II. The Community Organizes........................................................................................................4

  CiteSeer

Summary: Acknowledgements......................................................................................................................... ii Executive Summary....................................................................................................................... iii

Starflower Foundation; Ella Elman; Ecologist Contents

361

II. The Community Organizes........................................................................................................3

  CiteSeer

Summary: Acknowledgements......................................................................................................................... ii Executive Summary....................................................................................................................... iii

Starflower Foundation; Ella Elman; Ecologist Contents

362

II. The Community Organizes............................................................................................5

  CiteSeer

Summary: Acknowledgements............................................................................................................. ii Executive Summary........................................................................................................... iii

Starflower Foundation; Ella Elman; Ecologist Contents

363

Learning II Factors that influence CC

  Multidisciplinary Databases and Resources Websites

Summary: rarely encounter the exact same stimulus twice Discrimination CS+ ---> UCS CS- ---> ____ · The stimuli will come to control responding: ­ The CS+ will elicit a CR ­ The CS- will not elicit a CR Discrimination 0

Coulson, Seana

364

Binghamton University Graduate Growth Initiative

  Materials Science Websites

Summary: academic programs and departments an opportunity to develop new tracks within degrees, new graduate certificates and new degree initiatives that can foster new avenues of intellectual pursuit and career be expanded to meet the growth initiatives; (ii) serve as a general call for proposals for new career

Suzuki, Masatsugu

365

-- Session II--

  CiteSeer

Summary: This Issues Paper by the Secretariat is submitted FOR DISCUSSION under Session II of the Global Forum on Competition to be held on 17 and 18 February 2005. JT00177871 Document complet disponible sur OLIS dans son format d'origine Complete document available on OLIS in its original format DAF/COMP/GF(2005)2


366

Revisited abundance diagnostics in quasars: Fe II/Mg II ratios

  Astrophysics (arXiv)

Summary: Both the Fe II UV emission in the 2000- 3000 A region [Fe II (UV)] and resonance emission line complex of Mg II at 2800 A are prominent features in quasar spectra. The observed Fe II UV/ Mg II emission ratios have been proposed as means to measure the buildup of the Fe abundance relative to that of the alpha-elements C, N, O, Ne and Mg as a function of redshift. The current observed ratios show large scatter and no obvious dependence on redshift. Thus, it remains unresolved whether a dependence on redshift exists and whether the observed Fe II UV/ Mg II ratios represent a real nucleosynthesis diagnostic. We have used our new 830-level model atom for Fe+ in photoionization calculations, reproducing the physical conditions in the broad line regions of quasars. This modeling reveals that interpretations of high values of Fe II UV/ Mg II are sensitive not only to Fe and Mg abundance, but also to other factors such as microturbulence, density, and properties of the radiation field. We find that the Fe II UV/ Mg II ratio combined with Fe II (UV)/ Fe II (Optical) emission ratio, where Fe II (Optical) denotes Fe II emission in 4000 - 6000 A can be used as a reliable nucleosynthesis diagnostic for the Fe/Mg abundance ratios for the physical conditions relevant to the broad-line regions (BLRs) of quasars. This has extreme importance for quasar observations with the Hubble Space Telescope and also with the future James Webb Space Telescope.

E. Verner; F. Bruhweiler; D. Verner; S. Johansson; T. Gull
2003-06-25

367

Different phosphorylated forms of RNA polymerase II and associated mRNA

  Biology and Medicine Websites

Summary: Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during processing factors are coupled to transcription through binding to RNA polymerase II (Pol II). The largest throughout the transcription cycle. [Key Words: RNA polymerase II; TFIIH; capping enzyme; Kin 28] Received


368

517.95:517.958:517.928(06) ii ii i ii: . .

  Mathematics Websites

Summary: ii ii i ii #12; .. I i i , i I i i 19 I : i ii ii i ii I · 1998 #12; 517.95:517.958:517.928(06) ii ii i ii: . . . / . I- ; .: .. iii i. ­ , 1998. ­ 280 . i i i i- i i ii. i i - 'i ii ii i i ­ i ii, i, , i, , -i i. i i i i ­ i - i . i , i i i. ii, ii, i i - i i

Popovych, Roman

369

RNA Polymerase II and TAFs Undergo a Slow Isomerization after the Polymerase Is Recruited to

  Chemistry Websites

Summary: RNA Polymerase II and TAFs Undergo a Slow Isomerization after the Polymerase Is Recruited requires that RNA polymerase II (Pol II) and the general transcription factors assemble on promoter DNA into mRNA is catalyzed by the enzyme RNA polymerase II (Pol II) in a complex process involving

Goodrich, James

370

Mechanotransduction through growth-factor shedding into

  Biology and Medicine Websites

Summary: volume, not requiring induction of force-dependent biochemical processes within the cell or cell membrane Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA ............................................................................................................................................................................. Physical forces elicit biochemical signalling in a diverse array of cells, tissues and organisms1

So, Peter

371

Factoring Factor Maps

  CiteSeer

Summary: . A noninjective bounded-to-one factor map from an irreducible shift of finite type onto a sofic system can be factored as a composition of other such maps in only finitely many ways (up to isomorphism). This generalizes to factor maps from systems with canonical coordinates to finitely presented dynamical systems. Section 0. Introduction The analysis of bounded-to-one and especially of resolving factor maps has played a key role in the study of various coding relations among shifts of finite type and Markov chains [2, 3, 7, 14, 20 ... ]. The classification of sofic systems up to topological conjugacy reduces to the classification of such maps, because sofic systems come with canonical resolving factor maps from shifts of finite type [15, 5]. The study of these maps is also at the heart of applications of symbolic dynamical ideas to the problem of efficiently coding data into and out of magnetic media [1, 12, 17]. The problem of determining when there exists a resolving map between tw...

Mike Boyle
1998-01-01

372

Economic Growth

  CiteSeer

Summary: We analyze an economy that lacks a strong legal-political institutional infrastructure and is populated by multiple powe*rful groups. Powerful groups dynamically interact via a,$scal process that effectively allows open access to the aggregate capital stock. In equzl~&ium, this leads to slow economic growth and a “‘voracity e,@ect, ” by which a shock, such as a terms o,f trade wind-,fall, perversely generates a more than proportionate increase in fiscal redistribution and reduces growth. We also show that a dilution in the concentration o,f power leads to,faster growth and a less procyclical response to shocks. (JEL F43, 010, 023, 040) Two common characteristics of developing countries that have grown slowly in the last several decades are the absence of strong legal and political institutions and the presence of multiple powerful groups in society. In this paper, we analyze a dynamic model of the economic growth process that contains these features. We employ the model to ask three questions. First, why does the combination of a weak institutional structure and fractionalization inside the governing elite generate slow growth? Second, what is the relationship between the concentration of power (the number of powerful groups) and growth? Third, why do such countries not only grow slowly but also frequently respond in a perverse fashion to favorable shocks, by increasing more than proportionally fiscal redistribution and investing in inefficient capital projects?

Philip R. Lane; Aaron Tornell; Philip R. Lane; Aaron Tornell
1976-01-01

373

Kinetics of heat-shock response and inclusion body formation during temperature-induced production of basic fibroblast growth factor in high-cell-density cultures of recombinant E

  CiteSeer

Summary: The kinetics of the heat-shock response and the formation of inclusion bodies in recombinant Escherichia coli TG1 were studied in glucose-limited high-cell-density cultures in response to temperature-induced production of human basic fibroblast growth factor (hFGF-2), a protein which partially aggregates into inclusion bodies. The maximum synthesis rates of heat-shock proteins were similar to those in a control cultivation with a strain carrying an expression vector without inducible structural gene. However, the maximum of induction for many heat-shock proteins including DnaK, ClpB, and HtpG was reached at least 30 min later when synthesis of hFGF-2 was simultaneously induced by the temperature upshift. During this first production phase, hFGF-2 was exclusively deposited in the insoluble cell fraction. Thereafter, accumulation of soluble hFGF-2 was observed, too, indicating that the recombinant protein needs heat-shock chaperones for proper folding at elevated temperatures. Strong recombinant protein production prolonged the synthesis of the majority of heat-shock proteins (including GroELS, DnaK, ClpB, and HtpG) even in a wildtype dnaK+ background. In contrast, the synthesis rates of the small heat-shock proteins IbpA and IbpB declined within 1 h to preinduction values in control and hFGF-2 producing cultures. In the producing cultivation, IbpA and IbpB synthesis ceased to an undetectable level when soluble hFGF-2 started to accumulate, whereas the synthesis rates of the other heat-shock proteins including those belonging to the DnaK and GroEL families remained high throughout the entire production phase.

Frank Hoffmann; Ursula Rinas
2000-01-01

374

General law of growth and replication. Growth equation and its applications

  CERN Preprints

Summary: We present significantly advanced studies of the previously introduced physical growth mechanism and unite it with biochemical growth factors. Obtained results allowed formulating the general growth law which governs growth and evolutional development of all living organisms, their organs and systems. It was discovered that the growth cycle is predefined by the distribution of nutritional resources between maintenance needs and biomass production. This distribution is quantitatively defined by the growth ratio parameter, which depends on the geometry of an organism, phase of growth and, indirectly, organism's biochemical machinery. The amount of produced biomass, in turn, defines the composition of biochemical reactions. Changing amount of nutrients diverted to biomass production is what forces organisms to proceed through the whole growth and replication cycle. The growth law can be formulated as follows: the rate of growth is proportional to influx of nutrients and growth ratio. Considering specific biochem...

Shestopaloff, Yu K
2012-01-01

375

II. METHODOLOGY

  CiteSeer

Summary: Abstract—The main objective of this project is to build an autonomous microcontroller-based mobile robot for a local robot soccer competition. The black competition field is equipped with white lines to serve as the guidance path for competing robots. Two prototypes of soccer robot embedded with the Basic Stamp II microcontroller have been developed. Two servo motors are used as the drive train for the first prototype whereas the second prototype uses two DC motors as its drive train. To sense the lines, lightdependent resistors (LDRs) supply the analog inputs for the microcontroller. The performances of both prototypes are evaluated. The DC motor-driven robot has produced better trajectory control over the one using servo motors and has brought the team into the final round.

A. A. Shafie; M. F. Alias; M. H. Ali; Line Following

376

1FOOD CONVERSION EFFICIENCY IN TRANSGENIC TILAPIA WITH ACCELERATED GROWTH

  CiteSeer

Summary: Growth is a complex process that is regulated by the interaction of different factors. The growth hormone stimulates growth in fish by producing an increase in DNA synthesis and subsequent cell division. However, the understanding of how the increased growth hormone levels interact with behavioural

Isabel Guillén; Antonio Morales; Mario Pablo Estrada; José De La Fuente

377

RESEARCH ARTICLE Open Access Cellular response to micropatterned growth

  Biology and Medicine Websites

Summary: and the response to injury both require cell growth, migration and morphological remodeling, guided by a complex to examine cell growth and differentiation on patterned substrates printed with the commonly studied growth that micropatterning is also useful for studying factors that inhibit growth as it can direct cells to grow along

Ruthazer, Edward

378

/ II 1. .

  Mathematics Websites

Summary: Ïðîãðàììà ýêçàìåíà ïî ñ/ê Ýôôåêòèâíûå àëãîðèòìû #22; II 1. Ïîèñê ìèíèìàëüíîãî ñå÷åíèÿ. 2. Ïîèñê êîðîòêèìè êîíúþíêöèÿìè, äîêàçàòåëü- ñòâî êîððåêòíîñòè è ïîëèíîìèàëüíîé îöåíêè âðåìåíè åãî ðàáîòû. 1 #12 ëèòåðàòóðà: 1. R.Motwani, P.Raghavan, #16;Randomized Algorithms#17;. Cambridge University Press, 1995. 2. R

Hirsch, Edward A.

379

Personal Details I wish my gift to remain anonymous II

  Environmental Sciences and Ecology Websites

Summary: like to make a donation by credit/debit card. Please debit my card the sum of £ Name on card Credit card number II II II II ­ II II II II ­ II II II II ­ II II II II Debit card number II II II II II II Security number II II II (the last 3 digits from the signature strip) Card type: Mastercard II Visa II CAF

Oxford, University of

380

Improved parametrization of the growth index for dark energy and DGP models

  General Relativity & Quantum Cosmology (arXiv)

Summary: We propose two improved parameterized form for the growth index of the linear matter perturbations: (I) $\\gamma(z)=\\gamma_0+(\\gamma_{\\infty}-\\gamma_0){z\\over z+1}$ and (II) $\\gamma(z)=\\gamma_0+\\gamma_1 \\frac{z}{z+1}+(\\gamma_{\\infty}-\\gamma_1-\\gamma_0)(\\frac{z}{z+1})^{\\alpha}$. With these forms of $\\gamma(z)$, we analyze the accuracy of the approximation the growth factor $f$ by $\\Omega^{\\gamma(z)}_m$ for both the $\\omega$CDM model and the DGP model. For the first improved parameterized form, we find that the approximation accuracy is enhanced at the high redshifts for both kinds of models, but it is not at the low redshifts. For the second improved parameterized form, it is found that $\\Omega^{\\gamma(z)}_m$ approximates the growth factor $f$ very well for all redshifts. For chosen $\\alpha$, the relative error is below 0.003% for the $\\Lambda$CDM model and 0.028% for the DGP model when $\\Omega_{m}=0.27$. Thus, the second improved parameterized form of $\\gamma(z)$ should be useful for the high precision constraint on the growth index of different models with the observational data. Moreover, we also show that $\\alpha$ depends on the equation of state $\\omega$ and the fractional energy density of matter $\\Omega_{m0}$, which may help us learn more information about dark energy and DGP models.

Jiliang Jing; Songbai Chen
2010-02-25

381

Interaction between Transcription Elongation Factors and mRNA 3 -End Formation at the Saccharomyces cerevisiae

  Biology and Medicine Websites

Summary: Interaction between Transcription Elongation Factors and mRNA 3 -End Formation at the Saccharomyces, California 95616 Spt6 is a conserved transcription factor that associ- ates with RNA polymerase II (pol II elongation factor, Spt4, and pol II can affect 3 -end formation at GAL10. Additional analysis suggests

Winston, Fred

382

1Il!11: m:mm:lli11I,111 Illili:llili!!ill,1ll ill ill!!ii111,111,111 mm; 206 THE HUMAN FACTOR HAS KNOCKED THREE TIMES

  Computer Technologies and Information Sciences Websites

Summary: ................................................................................................................................ THE HUMAN FACTOR HAS KNOCKED THREE TIMES Three books on the ergonomics of computing systems B. Meyer SOFTWARE PSYCHOLOGY: HUMAN FACTORS IN COMPUTER AND INFORMATION SYSTEMS, by B. Shneiderman. Winthrop 3-540-10574-3 and 0-387-10574-3. THE PSYCHOLOGY OF HUMAN-COMPUTER INTERACTION, by S.P. Card, T

Meyer, Bertrand

383

Revisited abundance diagnostics in quasars: Fe II/Mg II ratios

  CERN Preprints

Summary: Both the Fe II UV emission in the 2000- 3000 A region [Fe II (UV)] and resonance emission line complex of Mg II at 2800 A are prominent features in quasar spectra. The observed Fe II UV/ Mg II emission ratios have been proposed as means to measure the buildup of the Fe abundance relative to that of the alpha-elements C, N, O, Ne and Mg as a function of redshift. The current observed ratios show large scatter and no obvious dependence on redshift. Thus, it remains unresolved whether a dependence on redshift exists and whether the observed Fe II UV/ Mg II ratios represent a real nucleosynthesis diagnostic. We have used our new 830-level model atom for Fe+ in photoionization calculations, reproducing the physical conditions in the broad line regions of quasars. This modeling reveals that interpretations of high values of Fe II UV/ Mg II are sensitive not only to Fe and Mg abundance, but also to other factors such as microturbulence, density, and properties of the radiation field. We find that the Fe II UV/ Mg II...

Verner, E M; Verner, D A; Johansson, S; Gull, T R
2003-01-01

384

Data Analysis II Winter 2012

  Biology and Medicine Websites

Summary: 1 Data Analysis II Psy 612 CRN 25306 Winter 2012 1000-1120 TR Condon 260 Instructor: Robert Mauro/7 Representation of Experimental Designs 2/9 Factorial Analysis of Variance K&W Section III Midterm Out 2/14 Random Factor Models & Quasi-F's K&W 24 2/16 Nested Designs K&W 25 MIDTERM DUE 10:00 AM by e-mail 2/21 Repeated

Lockery, Shawn

385

ii i i , i i i i ii I

  Mathematics Websites

Summary: ii i i , i i i i ii I I 512.536.7 Ii i i' i ii ii 01.01.06 i i i- i 2012 #12;i . i i i i i - i i ii I ii i i , i . i: i- , , ii i , i i i ii I , i i i. iii : i- , I , i i ii , i ii i i; i- i , i i ii , i. i 26 2012 . 15 i ii ii 35.051.18 i i

Banakh, Taras

386

A presynaptic endosomal trafficking pathway controls synaptic growth signaling

  MIT - DSpace

Summary: Structural remodeling of synapses in response to growth signals leads to long-lasting alterations in neuronal function in many systems. Synaptic growth factor receptors alter their signaling properties during transit through ...

Rodal, Avital A.

387

ii i i , i i i i ii I

  Mathematics Websites

Summary: ii i i , i i i i ii I I 512.536.7 Ii i i' i ii ii 01.01.06 i i i- i i , i- , , ii i 2012 #12;2 I 3 i 1. i, i i - ii ii 11 1.1. I i, i i i 11 1.2. i ii . . . . . . . . . . . . . . 19 i 2. i i'- i - 33 2.1. i i i I (N) . . . . . . . . . . 35 2.2. ii i i i

Banakh, Taras

388

Introduction Factorization

  Mathematics Websites

Summary: A Friendly Introduction to Factorization Theory Chapman Introduction The Language of Factorization: A Friendly Introduction to the Theory of Non-Unique Factorization in Integral Domains and Monoids Scott Chapman Sam Houston State University December 3, 2008 Chapman A Friendly Introduction to Factorization

Chapman, Scott

389

for ID12 and Tumor Necrosis Factor c ~ Production

  CiteSeer

Summary: The production of cytokines in monocytes/macrophages is regulated by several different cytokines that have activating or inhibitory effects. Interleukin (IL)-10, IL-4, IL-13, and transforming growth factor (TGF)- ~ are usually considered to be the most important macrophage-deactivating factors, with inhibitory effects on cytokine production. Unlike IL-IO and TGF-/3, which appear to act as downmodulators of many phagocytic cell functions, the mode of action of IL-4 and IL-13 is more complex. Addition of IL-4 and IL-13 to peripheral blood mononuclear cell (PBMC) cultures inhibited production of II.-12, tumor necrosis factor (TNF)-o~, IL-10, and II:1/ ~ induced by lipopolysaccharide (LPS) or Staphylococcus aureus added simultaneously with the cytokines. However, pretreatment of PBMC with II.-4 or I1.-13 for>--20 h enhanced the production of I1.-12 and TNF< ~ in response to LPS or S. aureus several fold in these cells; this IL-4-induced priming for the two cytokines was inhibited by anti-IL-4 neutralizing antibodies. IL-4 priming also enhanced the accumulation of IL-12 and TNF-ot mR.NA induced by LPS and S. aureus. The enhanced accumulation of transcripts for the 1I.-12 p35 and p40 chains by IL-4 priming was reflected in enhanced secretion of both the IL-12 free p40 chain and the p70 heterodimer. These results suggest an unexpected complexity in the regulatory role of IL-4 and IL-13 in immune responses.


390

Platelet-Derived Growth Factor and Basic Fibroblast Growth Factor Regulate Cell

  Biology and Medicine Websites

Summary: ., 1989; Gard and Pfeiffer, 1993), bFGF (Grinspan et al., 1993) and neurotrophin-3 (NT-3) (Barres et al, bFGF or astrocyte-conditioned medium had protective effects on the cells, by increasing cell- cubation of N38 cells with either PDGFaa or bFGF, how- ever, induced a polarized distribution

Bongarzone, Ernesto R.

391

Short Communication Reproduction of honeybee workers is regulated by epidermal growth

  Biology and Medicine Websites

Summary: Short Communication Reproduction of honeybee workers is regulated by epidermal growth factor Keywords: Reproductive division Epidermal growth factor receptor Fertility Hymenoptera Honeybee Apis, also induces reproduc- tion in worker honeybees (Apis mellifera). These data show that worker fertility

Wenseleers, Tom

392

SURVIVAL AND PROLIFERATION FACTORS OF NORMAL AND MALIGNANT PLASMA CELLS

  Computer Technologies and Information Sciences Websites

Summary: as a myeloma cell growth factor by Dr Kawano's and Dr Klein's groups 14 years ago, numerous studies have plasma cell generation are mostly unknown. Regarding malignant plasma cells, three categories of growth cell growth factors and of the associated transduction pathways should provide novel therapeutic

Boyer, Edmond

393

NECROSIS FACTOR AND TUMOR

  CiteSeer

Summary: Activated monocytes produce a variety of cytokines that are involved in inflammation, such as IL-1, TNF, chemotactic factors, transforming growth factor R, platelet-derived growth factor, and IFN-a and-Q (1). Chemotactic factors released at foci of injury or bacterial invasion are thought to mediate directed migration of leukocytes into inflammatory sites. Since the leukocyte composition of the inflammatory infiltrate depends on the temporal stage of the lesion (2) and the nature of the stimulus (3), it follows that some chemoattractants should be specific for a given type of leukocyte. We recently showed that LPS-stimulated monocytes produce a chemotactic factor that attracts neutrophils, but not monocytes (4). We purified this factor to homogeneity and described the N1-12-terminal sequence of the first 42 amino acids (5). We now report molecular cloning and sequencing ofthe full-length cDNA for this monocyte-derived neutrophil chemotactic factor (MDNCF) ' and the deduced amino acid sequence of the entire molecule. Specific cDNA probes also enabled us to test the capacity of a number of cytokines to induce MDNCF mRNA expression in human PBMC. The stimulation of MDNCF mRNA expression by IL-1 and TNF suggests that the local pro-inflammatory action of these cytokines may be mediated by induction of chemotactic factor secretion. Materials and Methods cDNA Cloning ofMDNCF and Nucleotide Sequence. Normal human PBMC were first fractionated by Ficoll-Hypaque and plastic adherent cells (> 90 % nonspecific esterase-positive monocytes), were cultured in RPMI-1640 medium supplemented with 1 % FCS and 10 ug/ml


394

Growth and dissipation in biological tissues D. Ambrosi, A. Guillou,

  Mathematics Websites

Summary: by many factors, including genetical predisposition, mechanical stimuli and availability of nutrients regard growth as a change in mass and geometry, while remodelling is taken to represent modifications

Ambrosi, Davide

395

Bioclimatology Water deficits during reproductive growth

  Physics Websites

Summary: of water status under field controlled conditions, comparing an irrigated check with treatments with im- posed water deficiencies. Statistically significant differences were found between treatments in predawnBioclimatology Water deficits during reproductive growth of soybeans. II. Water use and water

Paris-Sud XI, Université de

396

Growth Strategies

  CiteSeer

Summary: This is an attempt to derive broad, strategic lessons from the diverse experience with economic growth in last fifty years. The paper revolves around two key arguments. One is that neoclassical economic analysis is a lot more flexible than its practitioners in the policy domain have generally given it credit. In particular, first-order economic principles—protection of property rights, market-based competition, appropriate incentives, sound money, and so on—do not map into unique policy packages. Reformers have substantial room for creatively packaging these principles into institutional designs that are sensitive to local opportunities and constraints. Successful countries are those that have used this room wisely. The second argument is that igniting economic growth and sustaining it are somewhat different enterprises. The former generally requires a limited range of (often unconventional) reforms that need not overly tax the institutional capacity of the economy. The latter challenge is in many ways harder, as it requires constructing over the longer term a sound institutional underpinning to endow the economy with resilience to shocks and maintain productive dynamism. Ignoring the distinction between these two tasks leaves reformers saddled with impossibly ambitious, undifferentiated, and impractical policy agendas.

Dani Rodrik
2003-01-01

397

Growth and Ideas

  CiteSeer

Summary: INTRODUCTION People in countries like the United States are richer by a factor of about 10 or 20 than people a century or two ago. Whereas U.S. per capita income today is $33,000, conventional estimates put it at $1800 in 1850. Yet even this difference likely understates the enormous increase in standards of living over this period. Consider the quality of life of the typical American in the year 1850. Life expectancy at birth was a scant 40 years, just over half of what it is today. Refrigeration, electric lights, telephones, antibiotics, automobiles, skyscrapers, and air conditioning did not exist, much less * This is a draft of a chapter for the Handbook of Economic Growth. I am grateful to Philippe Aghion and Paul Romer for helpful comments, and to the National Science Foundation for research support. the more sophisticated technologies that impact our lives daily in the 21st century. Perhaps the central question of the literature on economic growth is "Why is there growth at

Charles I. Jones
2004-01-01

398

Title: In vitro meets in silico: measuring and modeling the influence of calcium gradients on cell In tissue engineering applications, scaffolds act as carriers for cells and growth factors that restore

  Computer Technologies and Information Sciences Websites

Summary: behavior. Background In tissue engineering applications, scaffolds act as carriers for cells and growthTitle: In vitro meets in silico: measuring and modeling the influence of calcium gradients on cell during an in vitro dissolution test. However, the reaction of the cells to these local calcium

Wolper, Pierre

399

Algebra Moderna II, 2008-II Michael Barot

  Mathematics Websites

Summary: Algebra Moderna II, 2008-II Michael Barot Fecha de entrega: 30/05/2008 http://www.matem.unam.mx/barot/cursos/2008-2.html Serie 7 1jDemuestra que el campo C de los n´umeros construibles es el campo m´as chico que

Barot, Michael

400

Intracellular control of developmental and regenerative axon growth

  Biology and Medicine Websites

Summary: regulated process that requires stimulating signals from extracellular factors. The extracellular signals signal regulated kinase (ERK) signalling in regulation of local axon assembly is less clear, but may coordinating with growth factor signalling. Finally, evidence is emerging that developmental versus

Zhou, Fengquan

401

Introduction Factorization

  Mathematics Websites

Summary: Theory Chapman Introduction and Motivation The Language of Non-Unique Factorizations Block Monoids Types Chapman Introduction and Motivation The Language of Non-Unique Factorizations Block Monoids Types and Motivation The Language of Non-Unique Factorizations Block Monoids Types of Monoids Examined

Chapman, Scott

402

Chap. II : Les structures

  Computer Technologies and Information Sciences Websites

Summary: Chap. II : Les objets structur´es Laurent Poinsot Chap. II : Les objets structur´es Laurent Poinsot 12 f´evrier 2009 #12;Chap. II : Les objets structur´es Laurent Poinsot Les objets structur´es Pour. 2/3), float (ex. 2.3, ) et complex (ex. 2 + 3 I). En les combinant, on peut construire des objets

Poinsot, Laurent

403

Zeus at HERA II

  HEP - Experiment (arXiv)

Summary: The ZEUS detector has been upgraded in a number of areas to prepare for the physics opportunities of HERA II. These upgrades, and their physics rationale and promise, are briefly outlined. The measurement of polarisation at HERA II, and its importance for the HERA II physics programme, is also discussed.

B. Foster
2001-07-24

404

-PTOLEMY II -HETEROGENEOUS CONCURRENT

  Engineering Websites

Summary: -PTOLEMY II - HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Christopher of Electrical Engineering and Computer Sciences University of California at Berkeley http://ptolemy with Ptolemy II 1.0 March 15, 2001 This project is supported by the Defense Advanced Research Projects Agency


405

Non Commutative Bianchi type II Quantum Cosmology

  General Relativity & Quantum Cosmology (arXiv)

Summary: In this paper we present the noncommutative Bianchi Class A cosmological models coupled to barotropic perfect fluid. The commutative and noncommutative quantum solution to the Wheeler-DeWitt equation for any factor ordering, to the anisotropic Bianchi type II cosmological model are found, using a stiff fluid ($\\gamma=1$). In our toy model, we introduce noncommutative scale factors, is say, we consider that all minisuperspace variables $\\rm q^i$ does not commute, so the simplectic structure was modified.

M. Aguero; J. A. Aguilar S.; C. Ortiz; M. Sabido; J. Socorro
2007-03-29

406

Growth of InAs Nanowires on SiO2 Substrates: Nucleation, Evolution, and the Role of Au Nanoparticles

  Engineering Websites

Summary: nanoparticles (NPs) enhance group V precursor (AsH3) pyrolysis but are not necessary to nucleate growth, (iiiAs nanowires. Many of these findings on InAs NW growth can be generalized to and provide very useful mechanisms specific to the growth technique and material system. Metal-assisted NW growth for group IV, II

Wang, Deli

407

ON THE FRACTURE AND FATIGUE CRACK GROWTH OF THIN SHEETS OF NANOCRYSTALLINE METAL ALLOYS BY

  CiteSeer

Summary: Fatigue crack growth was investigated in thin sheets of electrodeposited nickel– 1.6 % cobalt (Ni-Co) and rolled Inconel 718. Digital image correlation (DIC) was used to determine the crack opening displacement profiles, and the entire crack displacement fields. These parameters were then used to determine the magnitude of the crack tip stress intensity factor, and virtual extensometers were used to establish precisely the crack opening stress levels. The use of DIC enhanced the processing of experimental data and images, and gave detailed view of the crack tip stress intensity evolution with increasing crack length, transcending the limitations of previous measurement techniques. The Ni-Co alloy exhibits planar slip, has a nanocrystalline grain structure and high density of nanotwins as shown with extensive transmission electron microscopy. The crack growth rate exponent is less than 1.5 and the growth rates are finite stress intensity ranges as high as 100. We relate the fatigue crack growth resistance in the Ni-Co to slip-twin interactions, and the difficulty of slip to penetrate grain boundaries and annealing twins. ii Acknowledgments

John Oluseun Oyelakin

408

On Fatigue Crack Growth Using Cohesive Zone Model

  Engineering Websites

Summary: 8/8/2011 On Fatigue Crack Growth Using Cohesive Zone Model Kyoungsoo Park1; Glaucio H. Paulino2 (k-park@yonsei.ac.kr)8/8/2011 2 Contents Motivation Previous fatigue crack growth models Based-on stress intensity factors Nonlinear cohesive zone model Constitutive model of fatigue crack growth

Paulino, Glaucio H.

409

Knowledge intensive business services and long term growth

  Physics Websites

Summary: as a significant factor of economic growth. 1 Introduction Knowledge intensive business services (KIBS) can between knowledge intensive business services (KIBS) and the economic growth. Taking into account variousKnowledge intensive business services and long term growth Beno^it Desmarchelier, Faridah Djellal

Paris-Sud XI, Université de

410

ACCEPTED MANUSCRIPT Title Mechanical signals modulated Vascular Endothelial Growth

  Computer Technologies and Information Sciences Websites

Summary: (rat Ros17/2.8 and human osteoblasts) submitted to 4 mechanical regimens. Mechanical regimens (1 specifically expressed under high frequency in human osteoblasts. As F-actin stress fibers formation such as vascular endothelial growth factor A (VEGF) (57). VEGF in cooperation with the fibroblast growth factor

Boyer, Edmond

411

The Root Causes of Code Growth in Genetic Programming

  Computer Technologies and Information Sciences Websites

Summary: the concept of resilience in GP trees, and show that the buildup of resilience is essential for code growth programming by a factor that increases as the problem is scaled in difficulty. 1 Introduction The problem growth in this way leads to an improvement in performance by a factor that increases as the problem

Fernandez, Thomas

412

Journal of Crystal Growth 194 (1998) 321--330 Combined heat transfer in floating zone growth of large silicon

  Biology and Medicine Websites

Summary: Journal of Crystal Growth 194 (1998) 321--330 Combined heat transfer in floating zone growth the combined heat transfer in floating zone growth of large Si crystals with needle-eye technique factors associated with the components in the float zone furnace and both the diffuse and specular

Guo, Zhixiong "James"
1998-01-01

413

Effects of piscivore-mediated habitat use on growth, diet and zooplankton consumption of roach: an

  Biology and Medicine Websites

Summary: ; (ii) analyse the relevance of these habitat shifts for the diet, activity costs and growth of roach of roach to the littoral zone on roach diet, activity costs and growth. 2. The model suggests nutritious food items such as macrophytes, filamentous algae and detritus. 3. The growth of roach between May


414

Real-time optical diagnostics of graphene growth induced by pulsed chemical vapor deposition

  Materials Science Websites

Summary: the growth of graphene in (i) large single- crystals with (ii) controlled numbers of layers over (iii) largeReal-time optical diagnostics of graphene growth induced by pulsed chemical vapor deposition,b Norbert Thonnardb and Gyula Eresb The kinetics and mechanisms of graphene growth on Ni films at 720­880 C

Geohegan, David B.

415

ELSEVIER Journalof CrystalGrowth 175/176(1997)782-786 ,........ CRYITAL

  Materials Science Websites

Summary: . Experimental procedure The epitaxial layers were deposited by molecular beam epitaxy (MBE) using a Varian GenELSEVIER Journalof CrystalGrowth 175/176(1997)782-786 ,........ CRYITAL GROWTH MBE growth II system on 2 in (1 0 0) n÷-GaAs substrate oriented within + 0.5°. The preparation of the MBE

Ihn, Thomas

416

Bayes Factors

  CiteSeer

Summary: is one-half. Although there has been much discussion of Bayesian hypothesis testing in the context of criticism of P -values, less attention has been given to the Bayes factor as a practical tool of applied statistics. In this paper we review and discuss the uses of Bayes factors in the context of

Robert E. Kass; Adrian E. Raftery
1995-01-01

417

Original article Effect of a growth hormone infusion

  Physics Websites

Summary: ) and insulin-like growth factor-I (IGF-I) levels were deter- mined in Large White (LW) and Meishan (MS) femaleOriginal article Effect of a growth hormone infusion on plasma insulin-like growth factor and persistent rise in plasma IGF-I levels in both breeds. IGF-I response to GH was lower in LW than in MS pigs

Paris-Sud XI, Université de

418

Factored Language Models EE517 Lecture

  Computer Technologies and Information Sciences Websites

Summary: Language Models 5 Vocabulary Growth - full word forms Source: K. Kirchhoff, et al., "Novel Approaches;2 Factored Language Models 6 Vocabulary Growth - stemmed words Source: K. Kirchhoff, et al., "Novel.g. Geutner, 1995] · Parallel · [Kirchhoff et. al., JHU Workshop 2002] · [Bilmes & Kirchhoff, NAACL/HLT 2003

Duh, Kevin

419

Synergistic effect of obesity and lipid ingestion in suppressing the growth hormone response to exercise in children

  University of California eScholarship Repository

Summary: factor-1 and inflammatory response to a single exercise boutInflammatory cytokine, growth factor and counterregulatory responsesresponses, including secretion of immunomodulatory mediators (pro/ anti-inflammatory

Oliver, Stacy R.; Hingorani, Sunita R.; Rosa, Jaime S.; Zaldivar, Frank P.; Galassetti, Pietro R.
2012-01-01

420

-PTOLEMY II -HETEROGENEOUS

  Engineering Websites

Summary: -PTOLEMY II - HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Ron Galicia Mudit University of California at Berkeley http://ptolemy.eecs.berkeley.edu Document Version 0.1.1 February 12.2.8. Timed CSP and Timed PN 1-5 1.3.Choosing Models of Computation 1-6 1.4.Visual Syntaxes 1-6 1.5.Ptolemy II


421

PTOLEMY II HETEROGENEOUS

  Engineering Websites

Summary: ­PTOLEMY II ­ HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Ron Galicia Mudit University of California at Berkeley http://ptolemy.eecs.berkeley.edu Document Version 0.1.1 February 12 Syntaxes 1­6 1.5. Ptolemy II 1­7 1.5.1. Package Structure 1­7 1.5.2. Overview of Key Classes 1­9 1


422

Abstracts ii Schedule....................................................................................................................................................... iii

  Physics Websites

Summary: ...............................................................................................3 HAD II Special: Neptune after One Orbit: Reflections on the Discovery of a Planet ...........................................................................................5 Kavli Lecture: Cassini Eyes the Rings of Saturn

Ciotti, Luca

423

Type II universal spacetimes

  CERN Preprints

Summary: We study type II universal metrics of the Lorentzian signature. These metrics solve vacuum field equations of all theories of gravitation with the Lagrangian being a polynomial curvature invariant constructed from the metric, the Riemann tensor and its covariant derivatives of arbitrary order. We provide examples of type II universal metrics for all composite number dimensions. On the other hand, we have no examples for prime number dimensions and we prove non-existence of type II universal spacetimes in five dimensions. We also present type II vacuum solutions of selected classes of gravitational theories, such as Lovelock, quadratic and L(Riemann) gravities.

Hervik, Sigbjørn; Pravda, Vojt?ch; Pravdová, Alena
2015-01-01

424

Jan Hendrik Bruinier II Anna von Pippich Fabrizio Andreatta -Milan, Italy II Massimo Bertolini -Essen, Germany II Siegfried Bcherer -

  Mathematics Websites

Summary: , UK II Pierre Charollois - Paris, France II Gautam Chinta - New York, USA II Jens Funke - Durham, UK II Gerard Freixas - Paris, France II Eyal Goren - Montreal, Canada II Benjamin Howard - Boston, USA

Haller-Dintelmann, Robert

425

Empirical Verification of the Fe II Oscillator Strengths in the FUSE Bandpass

  Astrophysics (arXiv)

Summary: We report empirical determinations of atomic oscillator strengths, or f-values, for 11 ground-state transitions of Fe II in the wavelength range 1050 to 1150 Ang. We use ultraviolet absorption line observations of interstellar material towards stars in the Galaxy and the Magellanic Clouds taken with Copernicus, the Goddard High Resolution Spectrograph on-board the Hubble Space Telescope, and the Far Ultraviolet Spectroscopic Explorer. We derive absolute oscillator strengths by a combination of the apparent optical depth, component fitting, and curve-of-growth fitting techniques. Our derived oscillator strengths are generally in excellent agreement with recent theoretical calculations by Raassen & Uylings using the orthogonal operator technique. However, we identify three of the eleven transitions studied here whose f-values seem to be incompatible with these calculations, by as much as a factor of two. We suggest revisions to these f-values based upon our analysis.

J. Christopher Howk; Kenneth R. Sembach; Katherine C. Roth; Jeffrey W. Kruk
2000-07-17

426

On possible growth of Toeplitz languages

  CERN Preprints

Summary: We consider a new family of factorial languages whose subword complexity grows as $\\Theta(n^{\\alpha})$, where $\\alpha$ is the root of some transcendent equation. Analytical methods and in particular, a corollary of the Wiener-Pitt theorem, are used to find the asymptotic growth of the complexity. Factorial languages considered are languages of arithmetical factors of some Toeplitz words. So, we describe a new family of words with an unusual growth of arithmetical complexity.

Cassaigne, Julien; Petrov, Fedor
2010-01-01

427

Montag Dienstag Mittwoch Donnerstag Freitag Analysis II VL Analysis II VL

  Computer Technologies and Information Sciences Websites

Summary: Montag Dienstag Mittwoch Donnerstag Freitag Analysis II VL Analysis II VL Lineare Algebra II Ã? Analysis I Ã? Analysis II GÃ? Praktische Informatik II GÃ? Praktische Informatik II Ã? Lineare Algebra II A VL Analysis I Ã? Lineare Algebra II A VL Praktische Informatik II Ã? Lineare Algebra II Ã? Lineare Algebra II Ã?

Mannheim, Universität

428

18. Potencias Matematicas II, 2012-II 18. Potencias

  Mathematics Websites

Summary: 18. Potencias Matem´aticas II, 2012-II 18. Potencias Leyes de potenciaci´on La multiplicaci) = 103 La ley se resume de esta manera: am · bm = (a · b)m . 18-1 #12;Matem´aticas II, 2012-II 18 m . 18-2 #12;18. Potencias Matem´aticas II, 2012-II Exponentes negativos Hasta ahora en todos los

Barot, Michael

429

Strange Attractor in Immunology of Tumor Growth

  Nonlinear Sciences (arXiv)

Summary: The time delayed cytotoxic T-lymphocyte response on the tumor growth has been developed on the basis of discrete approximation (2-dimensional map). The growth kinetic has been described by logistic law with growth rate being the bifurcation parameter. Increase in the growth rate results in instability of the tumor state and causes period-doubling bifurcations in the immune+tumor system. For larger values of tumor growth rate a strange attractor has been observed. The model proposed is able to describe the metastable-state production when time series data of the immune state and the number of tumor cells are irregular and unpredictable. This metastatic disease may be caused not by exterior (medical) factors, but interior density dependent ones.

Margarita Voitikova
1997-08-21

430

Jones Index theory for type II von Neumann algebras

  Mathematics Websites

Summary: @mate.unlp.edu.ar Abstract R. Longo's definition of index ([L2]) is extended to the case where the in- volved algebras are not factors, assuming they are of type II. Main tools are generalizations of technics used by R. Longo for inclusions of factors ([L2, L3]), R. Longo has developed a new definition of index and also techniques used

Argerami, Martin

431

Bayes Factors

  CiteSeer

Summary: In a 1935 paper, and in his book Theory of Probability, Jeffreys developed a methodology for quantifying the evidence in favor of a scientific theory. The centerpiece was a number, now called the Bayes factor, which is the posterior odds of the null hypothesis when the prior probability on the null

Robert E. Kass; Adrian E. Raftery
1995-01-01

432

Testing factorization

  HEP - Phenomenology (arXiv)

Summary: We briefly review the status of factorization in $b$-decays. We discuss several experimental tests of its nature and stress their importance. We show that decays into mesons which have small decay constants or spin greater than one (`designer mesons') offer a variety of new opportunities.

Gudrun Hiller
2001-11-19

433

I.., . ., .. ii i i i

  Physics Websites

Summary: i i ¡ ¢ £ ¤¥ I I ' & $ % I.., . ., .. ii i i i : ICMP­03­18U I : 535.37 PACS: 75.30.Cr; 75.50.Mm; 61.44.Br; 32.50.+d ii i i i - : I.., .., .. i. i i , ii i i i - ii i ii, i i i - i . i i i , i iii i. i i i i i i . i i i, i ii i - i i i


434

Growth mechanism of nanostructured superparamagnetic rods obtained by electrostatic co-assembly

  Condensed Matter (arXiv)

Summary: We report on the growth of nanostructured rods fabricated by electrostatic co-assembly between iron oxide nanoparticles and polymers. The nanoparticles put under scrutiny, {\\gamma}-Fe2O3 or maghemite, have diameter of 6.7 nm and 8.3 nm and narrow polydispersity. The co-assembly is driven by i) the electrostatic interactions between the polymers and the particles, and by ii) the presence of an externally applied magnetic field. The rods are characterized by large anisotropy factors, with diameter 200 nm and length comprised between 1 and 100 {\\mu}m. In the present work, we provide for the first time the morphology diagram for the rods as a function of ionic strength and concentration. We show the existence of a critical nanoparticle concentration and of a critical ionic strength beyond which the rods do not form. In the intermediate regimes, only tortuous and branched aggregates are detected. At higher concentrations and lower ionic strengths, linear and stiff rods with superparamagnetic properties are produced. Based on these data, a mechanism for the rod formation is proposed. The mechanism proceeds in two steps : the formation and growth of spherical clusters of particles, and the alignment of the clusters induced by the magnetic dipolar interactions. As far as the kinetics of these processes is concerned, the clusters growth and their alignment occur concomitantly, leading to a continuous accretion of particles or small clusters, and a welding of the rodlike structure.

M. Yan; J. Fresnais; J. -F. Berret
2010-10-14

435

Human Factors: 05-413/05-813 Carnegie Mellon University

  Computer Technologies and Information Sciences Websites

Summary: 1 Human Factors: 05-413/05-813 Carnegie Mellon University Fall 2012 Instructor: Sara Kiesler & Thursday, 12 ­ 1:20 p.m. Gates (GHC) 4211 Human factors in the United States got its major start in World War II, as the American military enlisted human factors experts to help in the selection, training

Kiesler, Sara

436

Population GrowthPopulation Growth Population Parameters

  Environmental Sciences and Ecology Websites

Summary: of change in population size · Four parameters influence population growth ­ Births ­ Deaths ­ Immigration ­ Emigration Population Growth · Births (b) = NATALITY ­ addition of individuals due to birth/hatching/etc. ­ expressed as # births/unit time ­ (b) is a rate function · Crude birthrate ­ # births/unit time/1000

Cochran-Stafira, D. Liane

437

Americans Want Smarter Growth. Smart Growth America

  Environmental Sciences and Ecology Websites

Summary: Americans Want Smarter Growth. Smart Growth America Here's how to get there. #12;uring the past decade, many of America's towns and cities have expanded at a breakneck pace, leading to runaway sprawl- dies for sprawl fuel a migration away from cities, many urban neighborhoods and their residents have

Handy, Susan L.

438

TWOFACTORIZATIONS OF SMALL COMPLETE GRAPHS II: THE CASE OF 13 VERTICES

  Mathematics Websites

Summary: TWO­FACTORIZATIONS OF SMALL COMPLETE GRAPHS II: THE CASE OF 13 VERTICES F. Franek Department possible types of 2­ factorizations of the complete graph K 13 , there exists at least one solution. We A 2­factor of a graph G is a spanning subgraph of G which is regular of degree 2. A 2­factorization

Franek, Frantisek

439

RISK SENSITIVE CONTROL AND AN OPTIMAL INVESTMENT MODEL (II)

  Mathematics Websites

Summary: RISK SENSITIVE CONTROL AND AN OPTIMAL INVESTMENT MODEL (II) W. H. Fleming1 and S. J. Sheu2 Brown University and Academia Sinica Abstract. We consider an optimal investment problem proposed by Bielecki and Pliska. The goal of the investment problem is to optimize the long term growth of expected utility

Sheu, Shuenn-Jyi

440

Instructional Methods/Strategies II MSED 400 (3 credit hours)

  Mathematics Websites

Summary: Instructional Methods/Strategies II MSED 400 (3 credit hours) IIT's Mathematics and Science) Knowledge Growth in Teaching with the ultimate focus on the Teacher as Transformer of Subject Matter. The program focuses on the development, revision, and elaboration of six primary domains of knowledge

Heller, Barbara

441

Clinical Study Time-Dependent Changes of Plasma Concentrations of Angiopoietins, Vascular Endothelial Growth Factor, and Soluble Forms of Their Receptors in Nonsmall Cell Lung Cancer Patients Following Surgical Resection

  CiteSeer

Summary: Copyright © 2012 Ewa Kopczy?ska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Even when patients with nonsmall cell lung cancer undergo surgical resection at an early stage, recurrent disease often impairs the clinical outcome. There are numerous causes potentially responsible for a relapse of the disease, one of them being extensive angiogenesis. The balance of at least two systems, VEGF VEGFR and Ang Tie, regulates vessel formation. The aim of this study was to determine the impact of surgery on the plasma levels of the main angiogenic factors during the first month after surgery in nonsmall cell lung cancer patients. The study group consisted of 37 patients with stage I nonsmall cell lung cancer. Plasma concentrations of Ang1, Ang2, sTie2, VEGF, and sVEGF R1 were evaluated by ELISA three times: before surgical resection and on postoperative days 7 and 30. The median of Ang2 and VEGF concentrations increased on postoperative day 7 and decreased on

Ewa Kopczy?ska; Maciej Dancewicz; Janusz Kowalewski; Roman Makarewicz; Hanna Kardymowicz; Agnieszka Kaczmarczyk; Tomasz Tyrakowski
2012-01-01

442

Observational links between AGN evolution and galaxy growth

  Astrophysics (arXiv)

Summary: There is growing interest in the possible link between the growth of supermassive black holes and the effect of feedback from them on galaxy growth. There are three areas of significant uncertainty: (i) the physics of the feedback; (ii) the prevalence and effectiveness of feedback; (iii) the link between the growth of black holes and their hosts. The 2QZ optical QSO survey indicates that luminous QSOs are relatively short-lived, and it has recently been shown that the observed bolometric luminosity density from all AGN and its evolution can be reproduced if black holes grew coevally with their galaxies, implying but not requiring a causal link between galaxy growth and black hole growth. At low redshifts there is some evidence that black hole and galaxy growth are starting to decouple.

L. Miller
2006-11-21

443

PNUTS/PP1 Regulates RNAPII-Mediated Gene Expression and Is Necessary for Developmental Growth

  MIT - DSpace

Summary: In multicellular organisms, tight regulation of gene expression ensures appropriate tissue and organismal growth throughout development. Reversible phosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) ...

Ciurciu, Anita

444

1 REDWOOD YIELD RESEARCH COOPERATIVE DATA SET DOCUMENTATION GROWTH PLOTS2

  CiteSeer

Summary: This document provides a descriptionof growth plot data assimilatedduring the heyday of the Redwood Yield Research Cooperative. It is organized as follows: Part II. Provides a description of the structure of standard files (in terms of

I. Introduction

445

This paper discusses the calibration and assessment of a cellular automata model for urban growth modeling.

  Engineering Websites

Summary: models can be designed either for a specific geographical location such as BASS II which models), or as general models such as human- induced land transformations (HILT) where its growth rules are designed

Shan, Jie

446

Moderators of the Diffusion of Technological Innovation: Growth of the Japanese PC Industry

  University of California eScholarship Repository

Summary: and thus limited software growth). Apple has successfullyApple (1976), Multitech (1976)§, Compaq (1982), PCs Limited (1984)§§, Packard Bell Packaged softwareApple II. Visicalc was the crucial innovation — the first important PC application software

West, Joel
1996-01-01

447

~]~ERSPECTIVES Almost all of the studies to date in which growth

  Biology and Medicine Websites

Summary: ~]~ERSPECTIVES Almost all of the studies to date in which growth factors have been assessed with soluble growth factors. Nanogram per ml concentrations of activin, TGF-]32 and the FGFs can all cause some to differentiate into mesodernt All of the factors identified to date are related either tofibroblast growthfactor

Stern, Claudio

448

Does Financial Liberalization Spur Growth

  CiteSeer

Summary: We show that equity market liberalizations, on average, lead to a one percent increase in annual real economic growth over a five-year period. The effect is robust to alternative definitions of liberalization and does not reflect a business cycle effect. The channel of growth is both increased investment post liberalization which partially reflects a decreased cost of capital and increased factor productivity. The additional investment is largely financed by foreign capital leading to deteriorating trade balances. Some of the liberalization effect can be accounted for by coincidental macroeconomic reforms as well as financial development. However, our analysis shows that even after controlling for a broad range of variables, a statistically significant and economically important role is played by equity market liberalization. We appreciate the helpful comments of Wayne Ferson, Peter Henry, Ross Levine, Graciela Kaminsky,

Geert Bekaert; Campbell R. Harvey; Christian Lundblad; Han Kim; Luc Laeven; Michael Pagano; Vicente Pons; Tano Santos; Andrei Shleifer; René Stulz
2005-01-01

449

Quantum Mechanics II (Undergraduate)

  Environmental Sciences and Ecology Websites

Summary: : ''Quantum Computation and Quantum Error Prevention'' PHYSICS 440 Info httpQuantum Mechanics II (Undergraduate) Applications of Quantum Mechanics Spring, 2014 Physics 440 TEXTBOOK: Introduction to Quantum Mechanics (Second Edition), by David J. Griffiths, and QUNET's wikibook

Nickrent, Daniel L.

450

-PTOLEMY II -HETEROGENEOUS CONCURRENT

  Engineering Websites

Summary: Reekie Neil Smyth Jeff Tsay Yuhong Xiong Department of Electrical Engineering and Computer Sciences.5.Visual Syntaxes 1-8 1.6.Ptolemy II 1-9 1.6.1. Package Structure 1-9 1.6.2. Overview of Key Classes 1-12 1 Language 1-17 Package Diagrams 1-17 Static Structure Diagrams 1-17 Appendix: Ptolemy II Naming Conventions


451

J. Phys. II France 2 (1992) 1931-1940 NOVEMBER 1992, PAGE 1931 Classification

  Physics Websites

Summary: .20K 68.10H Statistical approach for radial fingering in a Hele Shaw cell J. C. Geminard ii) and P for the growth of the microstructure envelope which couples envelope radius, individual growth rate of fingers and the distribution function in the cell size space. In a preliminary approach, we neglect the important screening

Paris-Sud XI, Université de
1992-01-01

452

Protection and Damage Factors 1

  CiteSeer

Summary: The growth and well being of hardwoods, as with any other organism, are dependent on the total environment. Many of the factors affecting the hardwoods are considered normal elements in their environment, contributing to their productivity. Other factors are generally considered to be damaging to hardwoods. These agents would usually include diseases, insects, and fire. The specific term used tends to indicate the role the agent has. When we use the term disease or pathogen, the indication is that there is damage being done to the plant. Since disease may be any condition of the plant not considered normal and the pathogen as the causative agent,

Ca. Pacific; Southwest Forest; Robert E. Martin

453

LPA as a Paracrine Mediator of Adipocyte Growth and Function Cline Pagsa, Alexia Girarda, Olivier Jeannetona, Pierre Barbea, Claude Wolf b, Max

  Physics Websites

Summary: , such as insulin, catecholamines, IGF-I, growth hormone, glucocorticoids and thyroid hormone, are known to promote in understanding normal and pathologic growth of adipose tissue. Many hormones, growth factors and cytokines

Paris-Sud XI, Université de

454

Packing-limited growth of irregular objects Peter Sheridan Dodds1,

  Mathematics Websites

Summary: rectangles. By combining rectangles, we are able to form and examine a range of shapes whose growth patterns of populations. In Sec. II we describe the various objects we construct from rectangles. Although not all rectangles in Appendix B. II. IRREGULAR OBJECTS CONSIDERED The building block shape of the objects we

Dodds, Peter

455

factorization irreducible

  Mathematics Websites

Summary: (h(x)) (mod f(x)) with O(n 1:69 ) field operations. g(x) = d p ne X j=0 0 @ b p nc\\Gamma1 X l=0 c j;l x l 1 A \\Delta x b p nc\\Deltaj [c j;l ] \\Delta 2 6 6 6 6 6 6 4 \\Gamma \\Gamma \\Gamma \\Gamma \\Gamma \\Gamma ! h 0 irreducible distinct factors of degree d, q = p k */ Step 1 Pick a random ff mod f ; fi j ff + ff p + ff p 2

Kaltofen, Erich

456

PERSPECTIVES Allometric growth, life-history invariants and population energetics

  Environmental Sciences and Ecology Websites

Summary: , efficiency, life-history invariants, metabo- lism, population energetics, production, scaling. Ecology specific organisms or systems. Indeed, in many cases, context dependent and historically contingent factors, growth, and life history ultimately govern the energy transformations of populations and communities

Enquist, Brian Joseph

457

Journal of Crystal Growth 266 (2004) 552567 Three-dimensional crystal growth--II: nonlinear simulation

  Mathematics Websites

Summary: a prescribed heat flux J, only those perturbations with wave- numbers l such that JloJ grow unstable crystals. Our simulations reveal that when the far-field heat flux into the system is prescribed was predicted by our previous analysis (see Ref. Cristini and Lowengrub) and suggests that our theory

Lowengrub, John

458

Development of novel epidermal growth receptor-based radiopharmaceuticals: Imaging agents for breast cancer

  University of California eScholarship Repository

Summary: at California Breast Cancer Research Symposium, Septemberat California Breast Cancer Research Symposium, Fall 2001 “research was to develop epidermal growth factor receptor (EGFR) nuclear medicine breast cancer

Van Brocklin, Henry F.
2001-01-01

459

Plant physiology Growth and photosynthesis of Gossypium hirsutum L

  Physics Websites

Summary: maintenues indé- pendantes de celles de l'air à 20 °C ou 30 °C. La culture de plantes à des températures duPlant physiology Growth and photosynthesis of Gossypium hirsutum L at high photon flux densities: effects of soil temperatures and nocturnal air temperatures M Königer K Winter Lehrstuhl für Botanik II

Paris-Sud XI, Université de

460

Pricing Growth-Rate Risk Lars Peter Hansen

  Mathematics Websites

Summary: Pricing Growth-Rate Risk Lars Peter Hansen University of Chicago Jos´e A. Scheinkman Princeton functionals of a multi- dimensional Brownian motion. To study pricing we consider the pricing implications a direction of growth-rate risk exposure that is priced using the stochastic discount factor S. By changing

Hansen, Lars Peter

461

Fracture mechanics analysis of slow crack growth in polyethylene

  Texas A&M University - TxSpace

Summary: Slow crack growth in polyethylene is often the limiting factor in long-term service of plastic pipe or other structural applications. A new test method and analysis method was developed to study slow crack growth in polyethylene. Two high density...

Self, Robert Alan
1997-01-01

462

Exploring Structural and Dynamical Factors in the

  Computer Technologies and Information Sciences Websites

Summary: are in Part II, in their original publication format. The research has been conducted at the DepartmentExploring Structural and Dynamical Factors in the Evolution of Artificial Neural Networks Boye Annfelt Høverstad April 6, 2010 #12;#12;ABSTRACT Real-world networks, such as the network of neurons

Langseth, Helge

463

GROWTH-PROMOTING BACTERIA) AND PGPB

  CiteSeer

Summary: Bacteria that can increase plant growth and productivity have been known for over a century (Brown, 1974). Prominent among these organisms are species of the genus Rhizobium (Dejordjevic et al., 1987) whose potential and practical use in agriculture is beyond doubt (O'Gara et al., 1995). Although other bacterial species associated with plants, but, without creating symbiosis like Rhizobium. were discovered early in this century (Beijerinck. 1925), the fact that many of them were able to promote plant growth was not widely recognized. The breakthrough in this field occurred in the mid 1970s with (i) the discovery that some bacteria, mainly pseudomonads, are capable of controlling soil-borne pathogens to indirectly enhance plant growth (Kloepper and Schroth, 1978, Kloepper et al., 1980), and (ii) the re-discovery (Döbereiner and Day, 1976) of Azospirillum spp. (Beijerinck, 1925) which directly affect plant metabolism and consequent growth. These findings established two research approaches to bacterial inoculation (i) the biocontrol of plant pathogens (Kloepper et al., 1989), and (ii) Azospirillum-related organisms (Bashan and Levanony, 1990). Most bacteria in both groups are root associated, free living in soil or the phyllosphere and unlike Rhizobium or Agrobacterium form no apparent structural association with plant roots (Kloepper et al., 1989; Bashan and Levanony, 1990). Curiously, the two fields have developed almost independently of one another, yielding only few cross-citations (Glick, 1995; Institute for Scientific Information (Philadelphia) citation search, 1996 done by the *Author for correspondence. authors) in papers with subjects in common such as migration towards the plant, survival in soil and effects on plant growth. The primary barriers between these two fields have been of both taxonomic and functional nature.

Yoav Bashan; Gina Holguin
1997-01-01

464

Collective Wisdom: Information Growth in Wikis and Blogs Sanmay Das and Malik Magdon-Ismail

  Computer Technologies and Information Sciences Websites

Summary: at a faster rate (a rich get richer phenomenon); and, simultaneously, (ii) the chances that a new visitor. They suggest that Wikipedia follows a "rich get richer" stochastic geometric growth model in which articles rich-get-richer growth models, like the WH model, is that the total number of edits on a given wiki

Magdon-Ismail, Malik

465

Wakefield Induced Correlated Energy Spread and Emittance Growth at TTF FEL

  Physics Websites

Summary: 1 Wakefield Induced Correlated Energy Spread and Emittance Growth at TTF FEL Feng ZHOU DESY normalized emittance (2 mm.mrad) is required to drive a Free Electron Laser at the TESLA Test Facility (TTF and emittance growth at the TTF FEL of phase I and II. 1 Introduction The Free Electron Laser at the TESLA Test


466

A Meta-Analysis of the Determinants of Organic Sales Growth S. Cem Bahadir

  Mathematics Websites

Summary: of organic sales growth performance of firms: (i) innovation, (ii) marketing orientation, (iii) advertising that are under a manager's control, innovation, advertising, market orientation, interorganizational networks strategies. Organic growth involves developing new products and/or taking existing products to new markets

Parzen, Michael

467

Large-scale growth evolution in the Szekeres inhomogeneous cosmological models with comparison to growth data

  CERN Preprints

Summary: We use the Szekeres inhomogeneous cosmological models to study the growth of large-scale structure in the universe including nonzero spatial curvature and a cosmological constant. In particular, we use the Goode and Wainwright formulation, as in this form the models can be considered to represent exact nonlinear perturbations of an averaged background. We identify a density contrast in both classes I and II of the models, for which we derive growth evolution equations. By including Lambda, the time evolution of the density contrast as well as kinematic quantities can be tracked through the matter- and Lambda-dominated cosmic eras up to the present and into the future. In various models of class I and class II, the growth rate is found to be stronger than that of the LCDM cosmology, and it is suppressed at later times due to the presence of Lambda. We find that there are Szekeres models able to provide a growth history similar to that of LCDM while requiring less matter content and nonzero curvature, which spe...

Peel, Austin; Troxel, M A
2012-01-01

468

Factored Leave Accrual Why Factored Leave Accrual?

  Engineering Websites

Summary: Factored Leave Accrual #12;2 Why Factored Leave Accrual? · Why are we moving to Factored Leave Accrual? The switch to factored leave is part of UC San Diego's efforts toward standardization with other and non-exempt Staff employees will convert to Factored Leave Accrual 3 #12;4 Leave accruals for employees

Fainman, Yeshaiahu

469

Climate, Growth and Population Dynamics of Yukon River Chinook Salmon

  CiteSeer

Summary: in response to fewer returning salmon. We examined annual growth of age-1.3 and age-1.4 Yukon Chinook salmon scales, 1965–2004, and tested the hypothesis that shifts in Chinook salmon abundance were related to annual growth at sea. Annual scale growth trends were not significantly correlated with salmon abundance indices, sea surface temperature, or climate indices, although growth during the first year at sea appeared to have been affected by the 1977 and 1989 ocean regime shifts. Chinook salmon scale growth was dependent on growth during the previous year, a factor that may have confounded detection of relationships among growth, environmental conditions, and abundance. Scale growth during the second year at sea was greater in oddnumbered years compared with even-numbered years, leading to greater adult length of age-1.3 salmon in oddnumbered years. The alternating-year pattern in Chinook salmon growth was opposite that observed in Bristol Bay sockeye salmon, and it may be related to the higher trophic level of Chinook salmon and indirect competition with pink salmon. This finding highlights the need to investigate alternating-year patterns in salmon growth, prey abundance, and factors that influence these patterns, such as pink salmon.

Gregory T. Ruggerone; Jennifer L. Nielsen; Beverly A. Agler

470

A GATA Transcription Factor Recruits Hda1 in Response to Reduced Tor1 Signaling to Establish a Hyphal Chromatin State in Candida albicans

  University of California eScholarship Repository

Summary: affects filamentous growth ASG1 Gal4p family zinc-fingerand invasive growth; caspofungin repressed AHR1 Zinc-fingerzinc finger transcription factor required for wild-type biofilm formation; mutation affects filamentous growth;

Lu, Yang; Su, Chang; Liu, Haoping; Mitchell, Aaron P
2012-01-01

471

CHUKCHI BORDERLAND CRUISE Arctic West -Phase II (AWS-02-II)

  Geosciences Websites

Summary: Leader: Rebecca Woodgate, University of Washington Barrow, Alaska, 19th August - Barrow, Alaska, 23rd - Phase II (AWS-02-II) USCGC Polar Star Cruise Leader: Rebecca Woodgate, University of Washington Barrow

Washington at Seattle, University of

472

Repression of Runx2 function by TGF-b through recruitment of class II histone deacetylases

  Biology and Medicine Websites

Summary: Francisco, CA, USA Transforming growth factor-b (TGF-b) inhibits osteoblast differentiation through presents an accessible, physiological sys- tem to study how transforming growth factor-b (TGF-b) represses complex at the Runx2-binding DNA sequence. Accor- dingly, HDAC4 or 5 is required for efficient TGF

Derynck, Rik

473

MgII Absorbers: Halos or Disks?

  Astrophysics (arXiv)

Summary: We challenge the conventional view that the majority of MgII/Lyman limit absorbers are extended halos of galaxies comprised of ``clouds'' with near-unity covering factor. The gaseous disks of spiral galaxies are known to extend to large radii and likely contribute a significant cross-section for absorption. We perform a Monte-Carlo survey of QSO fields in which the model galaxies have MgII absorbing ``clouds'' in a spherical halo or in a randomly oriented disk. For both geometries, models that recover the observed properties of MgII absorbers have only a 70-80% covering factor. Therefore, regardless of absorber geometry, a survey of randomly selected QSO fields should yield a non-negligible number of non-absorbing galaxies at small impact parameters. Very few have been observed (Steidel (1995)). However, selection effects are important, and once the observational procedures are applied to our model fields we find that this result is expected. Since both spherical halo and disk models can be made consistent with survey results, we present tests for discerning the geometric distribution of absorbing gas from Hubble Space Telescope images and high resolution spectra.

Jane C. Charlton; Christopher W. Churchill
1996-01-22

474

Growth modes of quasicrystals

  Condensed Matter (arXiv)

Summary: The growth of quasicrystals, i.e., aperiodic structures with long-range order, seeded from the melt is investigated using a dynamical phase field crystal model. Depending on the thermodynamic conditions, two different growth modes are detected, namely defect-free growth of the stable quasicrystal and a mode dominated by phasonic flips which are incorporated as local defects into the grown structure such that random tiling-like ordering emerges. The latter growth mode is unique to quasicrystals and can be verified in experiments on one-component mesoscopic systems.

C. V. Achim; M. Schmiedeberg; H. Löwen
2014-05-21

475

pillar II measures

  CiteSeer

Summary: Areas payments) pillar II payments from the CAP make a relatively minor contribution to gross farm income compared to those from pillar I. The points covered in the paper are: 1. A brief outline of Islay; the history of farming, its influence on the landscape and its importance for nature conservation

Eric Bignal Efncp

476

Luminous type II Supernovae

  CERN Preprints

Summary: Context. In this paper we present spectroscopic and photometric observation of five type II supernovae (SNe), namely SNe 2009dd, 2007pk, 2010aj, 1995ad, and 1996W. Together with other few SNe they form a group of luminous type II events. Aims. We investigate the similarities and the differences among these five SNe, that represent the bulk of the luminous type II so far. We also attempt to characterise this subgroup of core-collapse SNe by analysing their spectral evolution, in order to find evidences of interaction that are common to them. Methods. We collect data ranging from the ultraviolet (UV) to the near-infrared (NIR) with several telescopes in order to construct well-sampled light curves and spectral evolutions from the photospheric to the nebular phase. Both photometric and spectroscopic evolution indicate significant differences among the objects and between them and other luminous type II SNe. Modelling the data of SNe 2009dd, 2010aj and 1995ad allows us to constrain the explosion parameters and th...

Inserra, C; Turatto, M; Pumo, M L; Benetti, S; Cappellaro, E; Botticella, M T; Bufano, F; Elias-Rosa, N; harutyunyan, A; Taubenberger, S; Valenti, S; Zampieri, L
2012-01-01

477

ANALYSIS II Spring 1998

  Computer Technologies and Information Sciences Websites

Summary: in Math 554 (Spring 96) Course Materials: General Reference 1. Real Analysis, A First Course, by Russell AANALYSIS II Math 555 Spring 1998 Instructor: Professor: Bob Sharpley Office: 313D LeConte Office. Principles of Real Analysis (3 rd ed.), by Walter Rudin, McGraw-Hill, 1976. 2. http

Sharpley, Robert

478

Physics at HERA II

  HEP - Phenomenology (arXiv)

Summary: Deep inelastic electron proton scattering at HERA II will allow precise studies of QCD and stringent tests of physics beyond the standard model. We discuss these two aspects of DIS with emphasis on the regime of high gluon densities at small $x$ and on scalar quark production in supersymmetric theories with broken R-parity.

W. Buchmüller
2001-11-15

479

Calculus II Spring 2012

  Mathematics Websites

Summary: Math 110 Calculus II Spring 2012 Professor: Pete Goetz CRN: 22882 Office: BSS 358 Office Hours 10:00 am ­ 10:50 am KA 104 Textbook: Single Variable Calculus: Early Transcendentals, 7th Edition 0%-55% Calculus Center: Calculus Center Calculus Drop-in Tutoring Spring 2012 BSS 308

Goetz, Peter

480

Calculus II Calculus III

  Engineering Websites

Summary: of Math electives 4 hrs of Science electives 12hours of CSE Technical Electives (*) #12;MATH 1426 Calculus I MATH 2425 Calculus II MATH 2326 Calculus III PHYS 1443 PHYS 1444 ENGL 1301) Math Placement Test/Advising (MATH prerequisite classes as needed) Prerequisite Co-requisite NOTE

Texas at Arlington, University of

481

Calculus -II Multivariable Calculus

  Mathematics Websites

Summary: of Technology Madras February 2007 Revised: January 2009 #12;Contents Preface v 1 Functions of Several Variables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 2 Multiple Integrals 35 2.1 Double Integrals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 2.1.1 Calculating double integrals . . . . . . . . . . . . . . . . . . . 37 ii #12;Contents iii 2

Nair, M.Thamban

482

PROGRAMMATION LES BASES II

  Mathematics Websites

Summary: PROGRAMMATION LES BASES II Le but de faire des histogrammes avec pylab de la distribution de Ball,Ball Set,Machine EXAMPLE : 2009-01-21,3,32,25,45,28,29,48,8,TOPAZ (1) Faire : x = '2009-01 les lignes dans un chier un par un for ligne dans fh.readlines(): faire qqchose> ex : liste

McShane, Greg

483

ii^-A ^"^m^

  Physics Websites

Summary: . Gentry. M. B. Hale, and J. M. Marchello. October 1972, iii -I- 175 p., 6 figs., 6 tables. For sale bv-^..;,^ :- '^y'-'^.^y ii^-A ^"^m^:: . .. i I ecnnicai Heport NMFS Circular Marine Flora and Fauna publications in the marine sciences. Individual copies may be obtained (unless otherwise noted) from D82


484

REGULATION II: The Council

  Mathematics Websites

Summary: REGULATION II: The Council 1. Composition of Council 1.1 As provided for within Section 3 of the Statutes of the University, the Members of the Council shall be as follows: Class (1): The Pro of the Students' Union. 2. Appointment or Election of Members of Council 2.1 Subject to the Statutes: 2


485

CSC6870 Computer Graphics II CSC6870 Computer Graphics II

  Computer Technologies and Information Sciences Websites

Summary: surfaces · Tensor product surfaces. · Surfaces of revolutions. · Sweeping surfaces. · Subdivision surfaces of Revolution #12;CSC6870 Computer Graphics II Surface of Revolution · Geometric construction ­ Specify a planar Computer Graphics II Sweeping Surface CSC6870 Computer Graphics II Sweeping Surface · Surface of revolution

Hua, Jing

486

Introduction to Matlab II 1 MATLAB, part II

  Mathematics Websites

Summary: Introduction to Matlab II 1 MATLAB, part II Simple data summaries ­ mean, variance, etc Built into Matlab are functions for simple data analysis. They include, mean, median, var, std (standard deviation to Matlab II 2 Now for some functions you do need to be a bit careful as the second argument may

Irwin, Mark E.

487

Epidermal growth factor (EGF) facilitates depilation of the Angora rabbit

  Physics Websites

Summary: of a weakness in the fibres (MOORE et al., 1981 b, 1982 a, b). The application of EGF as a wool harvesting agent with a synthetic EGF gene (ALLEN et al., 1987). The present report describes a preliminary study of the application on cellulose acetate gels. The EGF was dissolved in physiological saline and glycerol (1:1 v

Paris-Sud XI, Université de

488

Epidermal Growth Factor Receptor Tyrosine Kinase InhibitorResistant Disease

  Biology and Medicine Websites

Summary: : 10.1200/JCO.2012.43.3912 A B S T R A C T Purpose EGFR-mutant lung cancer was first described as a new the disease. Methods This article reviews the clinical implications of EGFR mutations in lung cancer of EGFR mutations has altered the ways in which we consider and treat non­small-cell lung cancer (NSCLC


489

INTRODUCTION Many polypeptide growth factors are expressed in the mam-

  Biology and Medicine Websites

Summary: concentrated on the peripheral visual system (optic nerve and retina), which is one of the simplest and best-characterized regions of the CNS. The optic nerve carries axons from ganglion neurons in the retina to the brain and optic nerve have been well documented, making these ideal organs for investigating cell

Richardson, William D.

490

Growth Hormone and Human Blood Clotting Factor 1

  CiteSeer

Summary: bacterial, yeast, mammalian or plant cells. One of the earliest examples of protein biopharmaceuticals was the use of recombinant DNA technology to modify ‘Escherichia coli ’ for the production of Human Insulin, which was followed by the development of Human

Victoria Brewster; Roger Jarvis; Royston Goodacre

491

ORIGINAL ARTICLE Altered expression of glutamate signaling, growth factor,

  Biotechnology Websites

Summary: in the locus coeruleus of patients with major depression R Bernard1,2, *, IA Kerman1, *, RC Thompson3 , EG of major depressive disorder (MDD). These conclusions were primarily drawn from post-mortem studies is associated with depressive symptoms and is thought to have a role in the pathophysiology of MDD


492

INTRODUCTION Neurotrophins are a family of soluble growth factors required

  Biology and Medicine Websites

Summary: in transgenic mice overex- pressing NT3 under the control of the promoter and enhancer regions of the nestin. At birth, transgenic DRG showed increased neuron numbers, and displayed a normal propor- tion of neurons exhibited an increased number of axons at birth, indicating that all sensory neurons in transgenic mice

Ibáñez, Carlos

493

REVIEW ARTICLE On the regulation of broblast growth factor

  Biology and Medicine Websites

Summary: in a protected and inactive form, and at the cell surface, where it activates its cognate signaling receptor. Here we review recent progress in elucidating how HLGAG regulates FGF-induced signal transduction. Data- ceptor, signal transduction. (Received 14 April 1997; accepted 5 May 1997) Extracellular matrix (ECM

Sasisekharan, Ram

494

Nonlinear Diffusion of a Growth Inhibitory Factor in Multicell Spheroids

  Mathematics Websites

Summary: the distribution of vital nutrients (e.g., oxygen) within the spheroids have been carried out 18, 13-15, 18-23, 26 in the central processes of inhibition of mitosis, consumption of nutrients, and cell proliferation as well

Maini, Philip K.

495

Introduction Members of the fibroblast growth factor (FGF) superfamily of

  Biology and Medicine Websites

Summary: ), nasal cavity, forebrain, lower jaw, eyelids and pinnae. Analysis of mutants indicates that although initial NP formation is grossly normal, cells in the Fgf8-expressing domain undergo high levels of apoptosis, resulting in cessation of nasal cavity invagination and loss of virtually all OE neuronal cell

McConnell, Susan

496

Biophysical characterisation of the hepatocyte growth factor - glycosaminoglycan interaction 

  Edinburgh, University of - Research Archive

Summary: , proliferation, chemotaxis, cell morphology, tissue regeneration and angiogenesis. It is involved in embryogenesis, wound healing and many cancers. In this project, the interactions between the GAG binding N and NK -domains of HGF (HGF-N and HGF-NK) and different...

Johansson, Conny M.
2011-11-23

497

Factors Promoting Personal Growth When Teaching Academically Diverse Classes

  University of Kansas - KU ScholarWorks

Summary: The study was conducted as a collaborative research project with 42 secondary science and social studies teachers in two school districts in eastern Kansas. Researchers and teachers met in a series of Cooperative Study ...

Lenz, B. Keith; Melvin, Jeff; Kissam, Brenda; Bulgren, Janis; Roth, Janet
1992-08-01

498

Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions

  MIT - DSpace

Summary: This thesis focuses on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer ...

Macdonald, Mara Lee
2010-01-01

499

Lipopolysaccharide Potentiates the Effect of Hepatocyte Growth Factor upon Replication

  Biology and Medicine Websites

Summary: , Thyroid, Spleen, and Colon in Rats in Vivo Cuihua Gao,*, Susan Kennedy,*, and Katherine Parker Ponder*,,1 University School of Medicine, St. Louis, Missouri 63110 Received for publication November 8, 2000; accepted

Ponder, Katherine P.

500

Some factors influencing digestion and growth rates of beef steers

  Texas A&M University - TxSpace

Summary: trials. . . . . 17 3. Ths effooto af varioss levels af dehydrated alfalfa leaf meal and trace minoTsle shen fod to Hereford oteer calves for a l&4lf pel icd ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ o ~ Ths offeots of varions levels of dehydrated alfalfa... leaf meal on tho concentration of carotene in the ration and on the carotene contont cf ths blood from steers fed these rations. . . 22 5. Consumption and apparent digestibility cf nutrients in all rations fed ~ ~ ' ~ ' ~ ~ ~ ~ ~ ' ~ ' I...

Gossett, John Warren
1955-01-01

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