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Sample search results for: growth factor ii

 

1

Insulin-like growth factor II : Cellular effects through different receptors.

  Open Access Theses and Dissertations

Summary: ??Insulin-like growth factor -II (IGF-II) and IGF-I are single-chain polypeptidesstructurally homologous to proinsulin and share similarities with insulin in functionalcharacteristics. Cellular actions of IGF-II are… (more)

Zhang, Qimin
1998-01-01

2

Transforming growth factor -receptor II protein expression in benign prostatic hyperplasia is associated

  Physics Websites

Summary: 1 Transforming growth factor -receptor II protein expression in benign prostatic hyperplasia is associated with prostate volume and inflammation. Descazeaud A, Weinbreck N, Robert G, Vacherot F, Abbou CC prostatic hyperplasia (BPH) using immunohistochemistry analysis, and to compare the analysis with phenotypic

Paris-Sud XI, Université de

3

Original article Evidence that growth factors IGF-I, IGF-II

  Physics Websites

Summary: maturation of porcine oocytes via intracellular protein kinase A Alexander V. SIROTKINa*, Janka DUKESOVÁa of growth factors and protein kinase A (PKA)-dependent intracellular mechanisms in the control of nuclear ng.mL­1 medium) and inhibitors of PKA (Rp-cAMPS or KT5720; 100 ng.mL­1). Stages of meiosis were

Paris-Sud XI, Université de

4

Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2: Randomized Controlled Phase II Clinical Trial

  CiteSeer

Summary: Background: The options for medical use of signaling molecules as stimulators of tissue regeneration are currently limited. Preclinical evidence suggests that fibroblast growth factor (FGF)-2 can promote periodontal regeneration. This study aimed to clarify the activity of FGF-2 in stimulating regeneration of periodontal tissue lost by periodontitis and to evaluate the safety of such stimulation. Methodology/Principal Findings: We used recombinant human FGF-2 with 3 % hydroxypropylcellulose (HPC) as vehicle and conducted a randomized double-blinded controlled trial involving 13 facilities. Subjects comprised 74 patients displaying a

Masahiro Kitamura; Keisuke Nakashima; Yusuke Kowashi; Takeo Fujii; Hidetoshi Shimauchi; Takashi Sasano; Toshi Furuuchi; Mitsuo Fukuda; Toshihide Noguchi; Toshiaki Shibutani

5

Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis

  CiteSeer

Summary: \\V'c investigated insulin-like growth factor II (IGF-II) mRNA in three groups of human liver samples including primary liver cancers, benign liver tumors and cirrhosis; indeed these pathological conditions would allow us to distinguish between different steps in liver carcinogenesis. A 40- to 100-fold increase in IGF-II mRNA was shown in 9/40 of the liver cancer samples as compared to normal adult liver. RNA blot analysis using both IGF-II cDNA and oligonucleotide probes showed the reexpression of two fetal (6 and 5 kilobases) IGF-II transcripts in primary liver cancers and in some cirrhotic adjacent tissues; these included all the samples with enhanced IGF-II expression. By contrast the adult (5.3

Elisabetta Cariani; Cantal Lasserre; Danielle Seurin; Et Al; Contact The Aacr Publications; Elisabetta Carfani; Chantal Lasserre; Danielle Seurin; Bernard Hamelin; Dominique Franco; Michael P. Czech; Axel Ullrich; Christian Brechot
1988-01-01

6

Printed in U.S.A. Copyright © 1999 by The Endocrine Society Postnatal Overexpression of Insulin-Like Growth Factor II in Transgenic Mice Is Associated with Adrenocortical

  CiteSeer

Summary: THE INSULIN-LIKE growth factor (IGF) system plays an important role in the regulation of adrenal growth and differentiation (1–3). IGF peptides, receptors, and binding proteins are synthesized by the adrenal glands of various species, and both IGF-I and IGF-II have been found to induce steroidogenesis and mitogenesis in adrenocortical cells in vitro (4–11). Accumulating data indicate that IGF-II not only is an important fetal adrenocortical growth factor but also is involved in the regulation of adult adrenal growth and function. In adult bovine and human adrenocortical cells, IGF-II enhances the steroidogenic effect of ACTH more potently than IGF-I. This effect is mediated through interaction with the IGF-I receptor and modulated by locally produced IGFbinding proteins (5, 11). Furthermore, IGF-II has been implicated in adrenocortical tumorigenesis, because overexpression of IGF-II and the IGF-I receptor are associated with adrenocortical malignacies (8, 12, 13).

Enhanced Steroidogenesis; Matthias M. Weber; Christian Fottner; Peter Schmidt; Kathrin M. H. Brodowski; Katinka Gittner; Harald Lahm; Dieter Engelhardt; Eckhard Wolf

7

Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching

  CiteSeer

Summary: Members of the transforming growth factor- ? (TGF-?) superfamily signal through heteromeric type I and type II serine/threonine kinase receptors. Transgenic mice that overexpress a dominant-negative mutation of the TGF- ? type II receptor (DNIIR) under the control of a metallothionein-derived promoter (MT-DNIIR) were used to determine the role of endogenous TGF-?s in the developing mammary gland. The expression of the dominant-negative receptor was induced with zinc and was primarily localized to the stroma underlying the ductal epithelium in the mammary glands of virgin transgenic mice from two separate mouse lines. In MT-DNIIR virgin females treated with zinc, there was an increase in lateral branching of the ductal epithelium. We tested the hypothesis that expression of the dominant-negative receptor may alter expression of genes that are expressed in the stroma and regulated by TGF-?s, potentially resulting in the increased lateral branching seen in the MT-DNIIR mammary glands. The expression of hepatocyte growth factor mRNA was increased in mammary glands from transgenic animals relative to the wild-type controls, suggesting that this factor may play a role in TGF-?mediated regulation of lateral branching. Loss of responsiveness to TGF-?s in the mammary stroma resulted in increased branching in mammary epithelium, suggesting that TGF-?s play an important role in the stromal–epithelial interactions required for branching morphogenesis.

Heather Joseph; Agnieszka E. Gorska; Philip Sohn; Harold L. Moses
1999-01-01

8

Caractrisation et volution physiologique des rcepteurs pour les insulin-like growth factors I et II (IGFs)

  Physics Websites

Summary: by differential centrifugations of ewe mammary gland homogenates. These membrane preparations contained specific during lactation. These results suggest that the mammary gland may constitute a target organ for IGFS. These factors could be involved in the regulation of mammary gland development and during cell differentiation

Paris-Sud XI, Université de

9

Growth factors in orthopedic surgery

  CiteSeer

Summary: Growth factors have represented an essential issue of interest for the researchers and clinicians in orthopedics and trauma over the last 40 years. In the last 10 to 15 years, the advances registered in this field have permitted the identification of the most active cellular and humoral factors as well as the improvement of their use in the orthopedic and trauma surgery. Their domain of application has been continuously enlarged and the results have been visible from the beginning. The authors present their appreciation on the actual state of this subject as well as their experience with results and related conclusions.

Corneliu Zaharia; Marius Niculescu; Nicoleta Despa

10

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Mutational Analysis of Activin/Transforming Growth Factor- ? Type I and Type II Receptor Kinases in Human Pituitary Tumors*

  CiteSeer

Summary: Genetic mutation or loss of activin/transforming growth factor-? (TGF?) receptor function has been shown in human lymphoid, breast, and colorectal tumors as well as Hep2B and Mv1Lu cell lines. Although activin stimulates FSH ? biosynthesis and secretion, a large percentage of human gonadotroph tumors have previously been demonstrated to be nonresponsive to characterized activin effects. This phenotype may be indicative of loss of functional cell surface receptors and/or intracellular signaling mediators of activin responses. Several studies examining the structure/function of type I and II receptors specific for ligands in the TGF ? superfamily have delineated the critical regions for receptor intracellular kinase function. In the case of TGF?, inactivating mutations in these regions have been shown to render these receptors kinase deficient by a dominant negative phenotype and result in resistance to growth arrest. We therefore hypothesized

F. Homero D’abronzo; Brooke Swearingen; Anne Klibanski; Joseph M. Alexander

11

The SCET_II and factorization

  HEP - Phenomenology (arXiv)

Summary: We reformulate the soft-collinear effective theory which includes the collinear quark and soft gluons. The quark form factor is used to prove that SCET$_{\\rm II}$ reproduces the IR physics of the full theory. We give a factorization proof in deep inelastic lepton-hadron scattering by use of the position space formulation.

Zheng-Tao Wei
2004-02-03

12

Attenuation of corneal myofibroblast development through nanoparticle-mediated soluble transforming growth factor-? type II receptor (sTGF?RII) gene transfer

  MIT - DSpace

Summary: Purpose: To explore (i) the potential of polyethylenimine (PEI)-DNA nanoparticles as a vector for delivering genes into human corneal fibroblasts, and (ii) whether the nanoparticle-mediated soluble extracellular domain of ...

Sharma, Ajay

13

MATERIAL FACTORS INFLUENCING METALLIC WHISKER GROWTH .

  Open Access Theses and Dissertations

Summary: ??DISSERTATION ABSTRACT MATERIAL FACTORS INFLUENCING METALLIC WHISKER GROWTH Chad L. Rodekohr Doctor of Philosophy December 19, 2008 (M.S., Auburn University, 2006) (B.S., Auburn University, 1997)… (more)

Rodekohr, Chad
2008-01-01

14

Growth Factor Receptor Signaling from Stroma*

  CiteSeer

Summary: Estrogens are crucial for growth and function of the female genital tract. Recently, we showed that induction of uterine epithelial proliferation by estradiol is a paracrine event requiring an estrogen receptor-positive stroma. Growth factors [such as EGF (epidermal growth factor) ligands] are likely paracrine mediators, which may directly or indirectly regulate epithelial proliferation in estrogen target organs via cell-cell interactions. In this report, we used mice with a null mutation in their EGF receptor (EGFR) to examine the role of EGFR signaling in growth of the uterus and vagina and in estrogeninduced uterine and vaginal epithelial proliferation. When WT and EGFR-knockout (EGFR-KO) uteri and vaginae were grown as renal capsule grafts in nude mice, growth of uterine and vaginal grafts of EGFR-KO mice was reduced, compared with their WT counterparts. Grafts of both EGFR-KO uteri and vaginae were about one third smaller (wet weight) than their corresponding WT organs, even

Growth Requires Epidermal; Yun Kit Hom; Peter Young; Jane F. Wiesen; Päivi J. Miettinen; Rik Derynck; Zena Werb; Gerald; R. Cunha

15

Fibroblast growth factors, their receptors and signaling

  CiteSeer

Summary: Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embryonic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.

C J Powers; S W Mcleskey; A Wellstein
2000-01-01

16

Growth factor parametrization in curved space

  General Relativity & Quantum Cosmology (arXiv)

Summary: The growth rate of matter perturbation and the expansion rate of the Universe can be used to distinguish modified gravity and dark energy models in explaining cosmic acceleration. We explore here the inclusion of spatial curvature into the growth factor. We expand previous results using the approximation $\\Omega_{m}^\\gamma$ and then suggest a new form, $f_a=\\Omega_m^\\gamma+(\\gamma-4/7)\\Omega_k$, as an approximation for the growth factor when the curvature $\\Omega_k$ is not negligible, and where the growth index $\\gamma$ is usually model dependent. The expression recovers the standard results for the curved and flat $\\Lambda$CDM and Dvali-Gabadadze-Porrati models. Using the best fit values of $\\Omega_{m0}$ and $\\Omega_{k0}$ to the expansion/distance measurements from Type Ia supernovae, baryon acoustic oscillation, WMAP5, and $H(z)$ data, we fit the growth index parameter to current growth factor data and obtain $\\gamma_{\\Lambda}(\\Omega_{k} \

Yungui Gong; Mustapha Ishak; Anzhong Wang
2009-03-02

17

Growth factor parametrization and modified gravity

  General Relativity & Quantum Cosmology (arXiv)

Summary: The growth rate of matter perturbation and the expansion rate of the Universe can be used to distinguish modified gravity and dark energy models in explaining the cosmic acceleration. The growth rate is parametrized by the growth index $\\gamma$. We discuss the dependence of $\\gamma$ on the matter energy density $\\Omega$ and its current value $\\Omega_0$ for a more accurate approximation of the growth factor. The observational data, including the data of the growth rate, are used to fit different models. The data strongly disfavor the Dvali-Gabadadze-Porrati model. For the dark energy model with a constant equation of state, we find that $\\Omega_0=0.27\\pm 0.02$ and $w=-0.97\\pm 0.09$. For the $\\Lambda$CDM model, we find that $\\gamma=0.64^{+0.17}_{-0.15}$. For the Dvali-Gabadadze-Porrati model, we find that $\\gamma=0.55^{+0.14}_{-0.13}$.

Yungui Gong
2008-08-09

18

Explaining Economic Growth: Factor Accumulation, Total Factor Productivity Growth, and Production Efficiency Improvement

  Engineering Websites

Summary: involves five geographic regions ­ Africa, East Asian, Latin America, South Asia, and the West. Factor possesses a positive and significant effect on output growth in Africa, East Asia, and the West. Labor

Ahmad, Sajjad

19

Nerve Growth Factor and Diabetic Neuropathy

  CiteSeer

Summary: Neuropathy is one of the most debilitating complications of both type 1 and type 2 diabetes, with estimates of prevalence between 50–90 % depending on the means of detection. Diabetic neuropathies are heterogeneous and there is variable involvement of large myelinated fibers and small, thinly myelinated fibers. Many of the neuronal abnormalities in diabetes can be duplicated by experimental depletion of specific neurotrophic factors, their receptors or their binding proteins. In experimental models of diabetes there is a reduction in the availability of these growth factors, which may be a consequence of metabolic abnormalities, or may be independent of glycemic control. These neurotrophic factors are required for the maintenance of the neurons, the ability to resist apoptosis and regenerative capacity. The best studied of the neurotrophic factors is nerve

Gary Pittenger; Aaron Vinik
2003-01-01

20

ORIGINAL RESEARCH Neuropeptides, Growth Factors, and Cytokines: A Cohort

  Biology and Medicine Websites

Summary: ). These included cytokines, growth factors and hormones, as well as converting enzymes, or protease inhibitors in the adrenal medulla. Keywords Adrenal medulla Á Chromaffin cell Á Cytokine Á Growth factor Á Hormone ÁORIGINAL RESEARCH Neuropeptides, Growth Factors, and Cytokines: A Cohort of Informational Molecules

Baker, Chris I.

21

Insulin-like growth factors and insulin-like growth factor binding proteins in wounds / James Gray Robertson.

  Open Access Theses and Dissertations

Summary: ??Thesis aimed to determine general roles for insulin-like growth factor binding proteins (IGFBPs) in regulating insulin-like growth factor-I (IGF-I) actions in wound repair. Preliminary experiments… (more)

Robertson, James Gray
1999-01-01

22

Nonlinear Diffusion of a Growth Inhibitory Factor in Multicell Spheroids

  Computer Technologies and Information Sciences Websites

Summary: Nonlinear Diffusion of a Growth Inhibitory Factor in Multicell Spheroids M. A. J. CHAPLAIN School A mathematical model is presented for the production of a growth inhibitory factor (GIF) within a multicell interrelated processes. Solid tumor growth is known to take place in two distinct phases-the avascular phase

Maini, Philip K.

23

ORIGINAL ARTICLE HEXIM1 modulates vascular endothelial growth factor expression

  Biotechnology Websites

Summary: ORIGINAL ARTICLE HEXIM1 modulates vascular endothelial growth factor expression and function that mutation of the C-terminus of transcription factor hexamethylene bisacetamide-induci- ble protein 1 (HEXIM1 growth factor (VEGF) expression. HEXIM1 regulation of some genes has also been shown to be positive


24

Identification of novel components in fibroblast growth factor signalling.

  Open Access Theses and Dissertations

Summary: ??Fibroblast growth factor receptors play many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling… (more)

Dudka, Anna Agnieszka
2010-01-01

25

Glycosaminoglycan-protein interactions : the fibroblast growth factor paradigm

  MIT - DSpace

Summary: Specific interactions between heparan sulfate glycosaminoglycans (HSGAGs) and proteins are central to a wide range of biological processes such as anticoagulation, angiogenesis and growth factor activation. The specificity ...

Kwan, Chi-Pong, 1973-
2002-01-01

26

RAPID COMMUNICATIONS AN ENDOTHELIAL CELL-DERIVED GROWTH FACTOR

  CiteSeer

Summary: Cell-free plasma-derived serum (PDS) is deficient in the platelet-derived growth factor and will not support the growth of 3T3 cells, fibroblasts, or smooth muscle cells. However, when PDS-containing medium is preincubated with endothelial cells, the medium becomes modified so that it will support growth. The activity produced by the endothelial cells results from a polypeptide of 10,000 to 30,000 daltons which has several features that differ from those of the platelet-derived growth factor, including heat instability and lack of adsorption to CM Sephadex. Growth of nontransformed cell strains in culture requires one or more exogenous growth factors. The availability of these polypeptides appears to determine the extent of growth, and account, at least in part, for the phenomenon of density-dependent inhibition of growth (12, 28, 31-33). In contrast, studies of endothelial cell strains have

Corinne Gajdusek; Paul Dicorleto; Russell Ross; Stephen M Schwartz
1980-01-01

27

STRONG SINGULARITY OF SINGULAR MASAS IN II1 FACTORS

  Mathematics Websites

Summary: STRONG SINGULARITY OF SINGULAR MASAS IN II1 FACTORS Allan M. Sinclair Roger R. Smith Stuart A@math.tamu.edu s.a.white-1@ed.ac.uk awiggins@math.tamu.edu Abstract A singular masa A in a II1 factor N is defined by the property that any unitary w N for which A = wAw must lie in A. A strongly singular masa A is one

Smith, Roger

28

Tempered Endoscopy for Real Groups II: spectral transfer factors

  Mathematics Websites

Summary: Tempered Endoscopy for Real Groups II: spectral transfer factors D. Shelstad Abstract and their relation to the geometric factors to prove an explicit version of the tempered spectral transfer theorem of orbital integrals and characters, is accessible for the tempered spectrum of real groups through

Shelstad, Diana

29

Insulin-like growth factor receptor expression and function in human breast cancer. Cancer Res

  CiteSeer

Summary: The insulin-like growth factors IGF-I and Idi-li are potent mitogens for several breast tumor cell lines in culture. Additionally, both IGF-I and IGF-II mRNAs are easily detected in the majority of breast tumor specimens examined, while no breast cancer epithelial cell lines we have studied express authentic IGF-I mRNA, and few lines express IGF-II iiiRNA. Although receptors for insulin, IGF-I, and IGF-II have been described, there is significant cross-reactivity between the various recep tors and ligands in the insulin/insulin-like growth factor family, and it is not clear which receptor or receptors are responsible for the biological effects of these growth factors in this system. Using an RNase protection assay, we examined breast tumor speci mens and breast cancer epithelial cell lines for expression of mRNA encoding the type I and type II IGF receptors as well as the insulin receptor. Virtually all of the specimens examined expressed mRNA for

Kevin J. Cullen; Douglas Yee; William S. Sly; Et Al; Contact The Aacr Publications; Kevin J. (alien; Douglas Yee; William S. Sly; James Perdue; Brian Hampton; Neal Rosen
1990-01-01

30

Characterizing and engineering antibodies against the epidermal growth factor receptor

  MIT - DSpace

Summary: Epidermal growth factor receptor (EGFR) signaling leads to cellular proliferation and migration, and thus EGFR dysregulation can significantly contribute to the survival of tumor cells. Aberrant EGFR signaling due to ...

Chao, Ginger
2008-01-01

31

Epidermal growth factor receptor downregulation by small heterodimeric binding proteins

  MIT - DSpace

Summary: No single engineered protein has been shown previously to robustly downregulate epidermal growth factor receptor (EGFR), a validated cancer target. A panel of fibronectin-based domains was engineered to bind with picomolar ...

Hackel, Benjamin J.

32

ORIGINAL ARTICLE Altered expression of glutamate signaling, growth factor,

  Biotechnology Websites

Summary: of select candidate genes was then interrogated using quantitative real-time PCR (qPCR) and in situ of altered glutamate, astroglial and growth factor functions in MDD for the first time to the brainstem


33

Transforming Growth Factor-s: signalisation et rles physio-pathologiques

  Physics Websites

Summary: dans la régulation de l'inflammation et la réparation tissulaire. Le TGF- est aussi impliqué dans Factor- (TGF-) family members are multifunctional peptide growth factors that regulate cell growth inflammation and tissue repair. Also, TGF- has been implicated in the pathogenesis of human diseases, including

Paris-Sud XI, Université de

34

Masas and Bimodule Decompositions of II_1 Factors

  Texas A&M University - TxSpace

Summary: ,j nsummationdisplay k=1 xi,kzk,j = 0, nsummationdisplay k=1 zi,kxprimek,j = xprimei,j. C. The Invariant We consider the conjugacy invariant for a masa A in a II1 factor M derived from writing the direct integral decomposition of its left-right action. More precisely...

Mukherjee, Kunal K.
2010-10-12

35

Hypoglykämie durch paraneoplastische Sekretion von Insulin-like Growth Factor-I (IGF-I) bei einer Patientin mit metastasiertem großzelligen Bronchialkarzinom.

  Open Access Theses and Dissertations

Summary: ??Erster Fall einer bisher nicht bekannten Pathogenese hypoglykämischer Episoden bei einer Patientin durch Insulin-like- growth-factor I im Unterschied zur klassischen IGF-II-vermittelten Tumor-Hypoglykämie. Bestimmung von Glukose,… (more)

Figge, Anja Margarete
2004-01-01

36

Molecular markers for growth hormone sensitivity in man : focus on growth hormone-binding protein and insulin-like growth factor I gene expression.

  Open Access Theses and Dissertations

Summary: ??Molecular markers for growth hormone sensitivity in man: Focus on growth hormone-binding protein and insulin-like growth factor I gene expression.Ragnar Bjarnason, International Pediatric Growth Research… (more)

Bjarnason, Ragnar 1959-
1997-01-01

37

Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

  CiteSeer

Summary: Neurons and glia are generated throughout adulthood from proliferating cells in two regions of the rat brain, the subventricular zone (SVZ) and the hippocampus. This study shows that exogenous basic fibroblast growth factor (FGF-2) and epidermal growth factor (EGF) have differential and site-specific effects on progenitor cells in vivo. Both growth factors expanded the SVZ progenitor population after 2 weeks of intracerebroventricular administration, but only FGF-2 induced an increase in the number of newborn cells, most prominently neurons, in the olfactory bulb, the normal destination for neuronal progenitors migrating from the SVZ. EGF, on the other hand, reduced the total number of newborn neurons reaching the olfactory bulb and substantially enhanced the generation of astrocytes in the olfactory bulb. Moreover, EGF increased the number of newborn cells in the striatum either by migration of SVZ cells or

H. Georg Kuhn; Jürgen Winkler; Gerd Kempermann; Leon J. Thal; Fred H. Gage

38

Mini-Review Employment of the Epidermal Growth Factor Receptor in Growth Factor–independent Signaling Pathways

  CiteSeer

Summary: THE traditional view of growth factor receptors and hormone receptors in general is that a specific ligand directly recognizes a highly selective binding site on its cognate receptor and, thereby, activates receptor-dependent signaling and biological responses. In the case of the EGF receptor, several structurally related proteins (EGF, transforming growth factor alpha, amphiregulin, betacellulin, epiregulin, heparin-binding EGF) are recognized as direct agonists. Each of these growth factors binds to the ectodomain of the EGF receptor and provokes its activation through a mechanism that involves dimerization, activation of the receptor tyrosine kinase cytosolic domain, and autophosphorylation of the receptor. This process initiates signaling pathways that lead to mitogenesis. Recently it has become apparent that the EGF receptor

Graham Carpenter

39

Synergism between a human growth hormone-releasing factor and thyrotropin-releasing factor on growth hormone release in relation

  Computer Technologies and Information Sciences Websites

Summary: on growth hormone release in relation with the stage of lactation of Holstein dairy cows (1) H. LAPIERRE D vaches Holstein en début, au pic et en fin de lactation (18, 72 et 210 jours, respectivement) ont reçu lactation. Human growth hormone-releasing factor (hGRF) and its fragment, (1-29)NH2, stimulate GH release

Boyer, Edmond

40

Shear stress magnitude and directionality modulate growth factor gene expression in

  Biotechnology Websites

Summary: Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned levels of 12 endothelial growth factor genes in response to alterations in wall shear stress (WSS) under nitric oxide synthase (NOS3), platelet-derived growth factor A, platelet-derived growth factor B (PDGFB

Passerini, Tony

41

Part II Impacts of Climate Change on Growth and Development

  CiteSeer

Summary: Part II considers how climate change will affect people’s lives, the environment and the prospects for growth and development in different parts of the world. All three dimensions are fundamental to understanding how climate change will affect our future. These effects will not be felt evenly across the globe. Although some parts of the world would benefit from modest rises in temperature, at higher temperature increases, most countries will suffer heavily and global growth will be affected adversely. For some of the poorest countries there is a real risk of being pushed into a downwards spiral of increasing vulnerability and poverty. Average global temperature increases of only 1-2°C (above pre-industrial levels) could commit 15-40 percent of species to extinction. As temperatures rise above 2-3°C, as will very probably happen in the latter part of this century, so the risk of abrupt and large-scale damage increases, and the costs associated with climate change – across the three dimensions of mortality, ecosystems and income – are likely to rise more steeply. In mathematical terms, the global damage function is

unknown authors

42

REVIEW ARTICLE Fibroblast growth factor signaling in mammalian tooth

  Biology and Medicine Websites

Summary: and odontoblasts, as well as in the development and homeostasis of the stem cell niche that fuels the continuously a number of cellular pro- cesses, including proliferation, differentiation, cell adhesion and cell mobility. Keywords Fibroblast growth factors Á Tooth development Á Adult stem cells Á Mouse Á Human Introduction

Klein, Ophir

43

Modelling hematopoiesis mediated by growth factors: Delay equations describing periodic

  Computer Technologies and Information Sciences Websites

Summary: and reg- ulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed to carry out explanation on some blood diseases, characterized by oscillations in circulating blood cells. A system of three differential

Boyer, Edmond

44

Discovering Small Molecule Ligands of Vascular Endothelial Growth Factor

  Materials Science Websites

Summary: -based assay platform that we used to identify inhibitors of vascular endothelial growth factor (VEGF)­ kinase detects binding of a target protein with SMM and identifies ligands to the protein as inhibitor candidates Institute and found 12 inhibitors to VEGF­KDR (VEGFR2) interactions with IC50 ranging from 0.3 to 60 l

Zhu, Xiangdong

45

A module of negative feedback regulators defines growth factor signaling

  Biology and Medicine Websites

Summary: and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor the function of signaling networks. Cells respond in a stereotypic and highly reproducible manner to external for deciphering organizational principles of signaling networks by analyz- ing the dynamics of network components


46

GAMES AND ELEMENTARY EQUIVALENCE OF II1 FACTORS ISAAC GOLDBRING AND THOMAS SINCLAIR

  Mathematics Websites

Summary: () and the property of being McDuff are both elementary properties (for separable II1 factors). Thus, if we let MDL be a separable II1 factor that has Property () but is not McDuff (see [3]), then MDL, the hyperfinite II1 factor

Goldbring, Isaac

47

TAYLOR MAP ON GROUPS ASSOCIATED WITH A II 1 -FACTOR MARIA GORDINA

  Mathematics Websites

Summary: TAYLOR MAP ON GROUPS ASSOCIATED WITH A II 1 -FACTOR MARIA GORDINA Abstract. A notion of the heat kernel measure is introduced for the L 2 com- pletion of a hyper#12;nite II 1 -factor with respect of this II 1 -factor in the L 2 norm induced by a trace on C is a Hilbert space L 2 (C). Elements

Gordina, Maria

48

Distribution and significance of the insulin-like growth factor-IIMannose-6 phosphate receptor in the central nervous system with special emphasis on the cholinergic system.

  Open Access Theses and Dissertations

Summary: ??The insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a multifunctional single transmembrane glycoprotein which mediates the trafficking of M6P-containing lysosomal enzymes from the trans-Golgi network to… (more)

Hawkes, Cheryl.
2005-01-01

49

Matrix rheology effects on reaction rim growth II: coupled diffusion and creep model

  Geosciences Websites

Summary: . If diffusion is rate limiting the usual linear proportionality between rim growth and ffiffi t p resultsMatrix rheology effects on reaction rim growth II: coupled diffusion and creep model D. W. SCHMID,1 for reaction rim growth in spherical geometry shows that the progress rate is proportional to the reaction

Podladchikov, Yuri

50

MATURE TLINEAGE LEUKEMIA WITH GROWTH FACTOR-INDUCED MULTILINEAGE DIFFERENTIATION

  CiteSeer

Summary: Human multipotent stem cell lines are of great interest for studies of hematopoietic differentiation and maturation and ofleukemogenesis. The advent of different stem cell assays (1-3) and the availability of recombinant or highly purified growth factors (4-7) made possible the identification of precursor cells and delineation of their growth factor dependency. Acute leukemias, which are believed to represent clonal expansions ofnormally occurring progenitor cells, have proved useful in defining different stages of normal differentiation (8). The use of such cells to study early events ofstem cell differentiation and maturation and to elucidate interlineage relationships has been limited by the lack of differentiation capacity in most leukemic cells. Recently, a TALL and a T-cell lymphoblastic lymphoma with in vivo and/or in vitro multilineage differentiation potential have been described that might serve as models to study hematopoietic stem cells. The TALL displayed in vitro and in vivo spontaneous and growth factor induced multilineage differentiation potential (9, 10), while the lymphoblastic lymphoma showed conversion to a bilineage Tlymphoid and myeloid leukemia at relapse (11). Both lymphoblastic processes displayed T cell precursor phenotypes of early thymocytes (CD2 + CD3- CD5 + CD7') or of prothymocytes (CD2- CD3-CD5`CD7'HLADR+TdT+) (12-14). These studies led

Frank Griesinger; Diane C Arthur; Richard Brunning; Janet L Parkin; Augusto C Ochoa; Wesley J Miller; Christopher W. Wilkowski; James M Greenberg; Carole Hurvitz; John H Kersey

51

Controlled delivery of platelet-rich plasma-derived growth factors for bone formation

  Engineering Websites

Summary: -derived growth factor, transforming growth factor beta-1, and insulin- like growth factor from two types phosphatase (ALP) activity of human osteoblast-like cells were also evaluated. It was found that factor and they promoted cell proliferation and ALP activity. These results demonstrate the potential of this autologous

Lu, Helen H.

52

Oberwolfach Reports 5 (2008), 21142115. Fundamental groups of II1 factors and equivalence relations

  Mathematics Websites

Summary: Oberwolfach Reports 5 (2008), 2114­2115. Fundamental groups of II1 factors and equivalence the fundamental group of a II1 factor and of a II1 equivalence relation and showed that it equals R+ in the hyperfinite case. Since then, the question which subgroups of R+ can arise as a fundamental group, attracted

Vaes, Stefaan

53

The effects of growth factors on testicular germ cell apoptosis in the stallion

  Texas A&M University - TxSpace

Summary: recombinant growth factors, stem cell factor (SCF), leukemia inhibiting factor (LIF), granulocyte macrophage-colony stimulating factor (GM-CSF), and one hormone, estradiol (E?), alone or in combination, to prevent apoptosis of germ cells in short-term equine...

Donnelly, Casey Leanne
2002-01-01

54

Regulation of mTOR complex 1 in response to growth factors and nutrients

  MIT - DSpace

Summary: In multicellular organisms, cells ensure the simultaneous availability of growth factors and nutrients before they invest in cellular processes that lead to growth. The TOR kinase is a master regulator of cellular growth ...

Sancak, Yasemin S. (Yasemin Shechner)
2010-01-01

55

TAYLOR MAP ON GROUPS ASSOCIATED WITH A II1-FACTOR MARIA GORDINA

  Mathematics Websites

Summary: TAYLOR MAP ON GROUPS ASSOCIATED WITH A II1-FACTOR MARIA GORDINA Abstract. A notion of the heat kernel measure is introduced for the L2 com- pletion of a hyperfinite II1-factor with respect of this II1-factor in the L2 norm induced by a trace on C is a Hilbert space L2 (C). Elements of the space L2

Gordina, Maria

56

Smoothed Analysis of the Condition Numbers and Growth Factors of Matrices

  Computer Technologies and Information Sciences Websites

Summary: Smoothed Analysis of the Condition Numbers and Growth Factors of Matrices Arvind Sankar Department of arbitrary matrices are unlikely to have large condition numbers or large growth factors under Gaussian of the condition numbers and growth factors of matrices, and review prior work on their average-case analysis

Spielman, Daniel A.

57

The Response of Dorsal Root Ganglion Axons to Nerve Growth Factor Gradients Depends on Spinal Level

  Biology and Medicine Websites

Summary: The Response of Dorsal Root Ganglion Axons to Nerve Growth Factor Gradients Depends on Spinal Level assay to generate precisely controllable nerve growth factor gradients, we show for the first time that the guidance and outgrowth response of rat dorsal root ganglion neurons to identical nerve growth factor

Goodhill, Geoffrey J.

58

Role of the interaction of proHB-EGF with heparan sulfate proteoglycans ; Role of the interaction of pro heparin-binding epidermal growth factor-like growth factor with HSPGs .

  Open Access Theses and Dissertations

Summary: ??Heparin-binding epidermal growth factor-like growth factor (HB-EGF) exhibits activity as a juxtacrine, paracrine, and autocrine ligand for the epidermal growth factor receptor (EGFR), and possesses… (more)

Prince, Robin Neely
2009-01-01

59

Deep-Sea Research II 50 (2003) 635653 Phytoplankton growth and biological response to iron

  Geosciences Websites

Summary: Deep-Sea Research II 50 (2003) 635­653 Phytoplankton growth and biological response to iron to determine the community response to added iron and zinc and their effect on phytoplankton growth. Seawater was collected into acid-cleaned 20-l polycarbonate carboys and incubated with varying additions of iron and zinc

Wang, Wendy

60

Nucleation and growth in one dimension. II. Application to DNA replication kinetics

  Materials Science Websites

Summary: Nucleation and growth in one dimension. II. Application to DNA replication kinetics Suckjoon JunS6 Received 30 July 2004; published 21 January 2005 Inspired by recent experiments on DNA replication, we apply a one-dimensional nucleation-and-growth model to DNA-replication kinetics, focusing


61

Vector-based RNA interference against vascular endothelial growth factor-A significantly limits vascularization and growth of

  Chemistry Websites

Summary: vascularization and growth of prostate cancer in vivo Francesca Wannenes,1,2,a Silvia Anna Ciafre´,1,a Francesco factor (VEGF) expression in prostate cancer in vitro and in vivo. We demonstrated that transduction the expression of this growth factor in the human prostate cancer cell line PC3. As a consequence, PC3 cells

Cai, Long

62

Effects of hypothalamic hormones (GRF, TRH, Somatostatin) and insulin-like growth factor I on growth hormone

  Physics Websites

Summary: Effects of hypothalamic hormones (GRF, TRH, Somatostatin) and insulin-like growth factor I on growth hormone secretion from prepubertal male lamb pituitary cultures Monique M. BLANCHARD Cynthia G hormone-releasing factor (GRF 1-44) stimulated GH release in a dose-related manner : the maximal effective

Paris-Sud XI, Université de

63

Growth as affected by general hormonal factors and hormonal balances, and the limitations of such studies

  Physics Websites

Summary: Growth as affected by general hormonal factors and hormonal balances, and the limitations France. Summary. Many elements are implicated in fetal and postnatal growth ; the hormonal factors are discussed in this review. In the first section, general hormonal effects on the growth of domestic animals

Paris-Sud XI, Université de

64

Printed in U.S.A. Copyright © 2001 by The Endocrine Society Minireview: Tissue-Specific Versus Generalized Gene Targeting of the igf1 and igf1r Genes and Their Roles in Insulin-Like Growth Factor Physiology

  CiteSeer

Summary: The insulin-like growth factors (IGF-I and IGF-II) and the IGF-I receptor are critically important for normal growth and development of the organism. Gene-deletion of these elements has demonstrated that IGF-I is important for both prenatal and postnatal development, whereas IGF-II is important during prenatal stages only. The IGF-I receptor gene-deleted mouse dies at birth apparently as a result of poor muscular development. Utilizing the conditional gene-deletion OF ALL growth factor families studied, one that will most surely benefit from the application of the new gene targeting technologies allowing temporal and cellspecific control of gene expression are the insulin-like growth factors. The expression of the various components of the insulin-like growth factor system of ligands (IGF-I/II), receptors (IGF-IR, IGF2R), and soluble binding proteins

Andrew A. Butler; Derek Leroith

65

It’s Not Factor Accumulation: Stylized Facts and Growth Models

  CiteSeer

Summary: We document five stylized facts of economic growth. (1) The “residual ” rather than factor accumulation accounts for most of the income and growth differences across nations. (2) Income diverges over the long run. (3) Factor accumulation is persistent while growth is not persistent and the growth path of countries exhibits remarkable variation across countries. (4) Economic activity is highly concentrated, with all factors of production flowing to the richest areas. (5) National policies closely associated with long-run economic growth rates. We argue that these facts do not support models with diminishing returns, constant returns to scale, some fixed factor of production, and that highlight the role of factor accumulation. Empirical work, however, does not yet decisively distinguish among the different theoretical conceptions of “total factor productivity growth.” Economists should devote more effort towards modeling and quantifying total factor productivity.

William Easterly; Ross Levine
2001-01-01

66

Brief Communication 1283 Platelet-derived growth factor is constitutively secreted from

  Biology and Medicine Websites

Summary: Brief Communication 1283 Platelet-derived growth factor is constitutively secreted from neuronal cannot predict the site(s) of action or the biological functions of many neuron-derived factors. For example, can neuronal platelet-derived growth factor (PDGF) be secreted from axons and reach glial cells

Richardson, William D.

67

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

  MIT - DSpace

Summary: Due to its common dysregulation in epithelial-based cancers and extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) is a highly validated target for anticancer therapies. There ...

Spangler, Jamie Berta

68

Characterization and informed design of downregulating anti-epidermal growth factor receptor antibodies

  MIT - DSpace

Summary: Due to its common dysregulation in epithelial-based cancers and the extensive characterization of its role in tumor growth, epidermal growth factor receptor (EGFR) has long been an attractive target for monoclonal antibodies. ...

Spangler, Jamie Berta
2011-01-01

69

Platelet-derived growth factor receptor alpha signaling pathways in development and liver disease.

  Open Access Theses and Dissertations

Summary: ??Platelet derived growth factor receptor alpha (PDGFR?) signaling is critical for development and disease. Insufficient PDGFR? signal transduction results in developmental anomalies, while excessive signaling… (more)

Hayes, Brian Joseph
2014-01-01

70

Factors associated with Intra-Uterine Growth Retardation newborns in public maternity in Salvador.

  Open Access Theses and Dissertations

Summary: ??Factors associated with Intra-Uterine Growth Retardation have not been fully clarified. Small newborns for gestational age have shown different hematological parameters compared appropriate newborns for… (more)

Maria de Fátima Fernandes Pussick Nunes
2007-01-01

71

REQUIREMENT OF THE DYNLRB FAMILY DYNEIN LIGHT CHAINS IN TRANSFORMING GROWTH FACTOR BETA SIGNALING.

  Open Access Theses and Dissertations

Summary: ??Transforming growth factor ? (TGF?) is the prototype for a superfamily of related members. TGF? family signaling controls various fundamental cellular functions, including cell proliferation… (more)

Gao, Guofeng
2006-01-01

72

Expression of paracrine growth factors and their receptors in the ovine uterus.

  Open Access Theses and Dissertations

Summary: ??Epithelial-mesenchymal interactions are necessary for epithelial cell proliferation, differentiation, and function in the uterus and are mediated, in part, by paracrine growth factors of stromal… (more)

Chen, Chen
2012-01-01

73

The effect of transforming growth factor beta1 null mutation on murine reproductive function.

  Open Access Theses and Dissertations

Summary: ??Transforming growth factor beta 1 (TGF?1) is a multifunctional cytokine implicated in gonad and secondary sex organ development, spermatogenesis and ovarian function, immunoregulation of pregnancy,… (more)

Ingman, Wendy Vanessa
2002-01-01

74

Molecular Cloud Structure in the Magellanic Clouds: II. CO-to-H2 Conversion Factor

  Physics Websites

Summary: Molecular Cloud Structure in the Magellanic Clouds: II. CO-to-H2 Conversion Factor Soojong Pak Way, the 12CO J = 1 ! 0 line traces the molecular gas content. The conversion factor, XGAL, between that of our Galaxy? The metallicity dependence of the conversion factor has been an issue. Cohen et al. (1988

Pak, Soojong

75

One-parameter automorphism groups of the injective factor of type II1 with Connes spectrum zero

  Mathematics Websites

Summary: One-parameter automorphism groups of the injective factor of type II1 with Connes spectrum zero-parameter automorphism group of the injec- tive type II1 factor with Connes spectrum {0} which is not stably conjugate of the injective type II1 factor such that all are stably con- jugate but no two are cocycle conjugate. §0

Kawahigashi, Yasuyuki

76

Fractionation studies on the unidentified growth factor(s) in distillers dried solubles

  Texas A&M University - TxSpace

Summary: ~i=tiiiers dried soluoles ln conceni, ration lrva i', . l 0 l?arid uiu not finu si, ni1'icuiit Ji1' ereiice 1ii Lne, ;ro. , tn o Lne ciiick l;ravens et al. ('yl) repoite t. ie e?li. tenne o1 u, rowth factor in torula geai;t. C?uc. i et, ui. ('?i... "rltrr ro?v toJ oy itunler urr- . r. roan i ')1, in wn'ch aport it;~ ue. on tr, ited t. iuu whole liver anu dried bre er= yeast ai ?cured to oe . ", o~d s . urces oi tai- l'aCtOr Wnile dried Wiiej, di tiller= dried ~ui Oie-, nid ter. ontat. on s...

Dannenburg, Warren Nathaniel
1955-01-01

77

The Confluent System Formalism: II. The Growth History of Objects

  Astrophysics (arXiv)

Summary: With the present paper we conclude the presentation of a semianalytical model of hierarchical clustering of bound virialized objects formed by gravitational instability from a random Gaussian field of density fluctuations. In paper I, we introduced the basic tool, the so-called ``confluent system'' formalism, able to follow the evolution of bound virialized objects in the peak model. This was applied to derive the mass function of objects. In the present paper, we calculate other important quantities characterizing the growth history of objects. This model is compared with a similar one obtained by Lacey \\& Cole (1993) following the Press \\& Schechter (1974) approach. The interest of the new modeling presented here is twofold: 1) it is formally better justified as far as peaks are more reasonable seeds of objects than the indetermined regions in the Press \\& Schechter prescription, and 2) it distinguishes between merger and accretion enabling us to unambiguously define the formation and destruction of objects and to estimate growth rates and characteristic times not available in the previous approach.

Alberto Manrique; Eduard Salvador-Sole
1995-11-02

78

Porous materials with two populations of voids under internal pressure: II. Growth and

  Physics Websites

Summary: Porous materials with two populations of voids under internal pressure: II. Growth and coalescence of voids Pierre-Guy Vincent a,b , Yann Monerie a,c , Pierre Suquet b,1 aInstitut de Radioprotection et de S is devoted to the mechanical behavior of polycrystalline materials with two populations of voids, small

Paris-Sud XI, Université de

79

Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol

  CiteSeer

Summary: Although it is known that the lung undergoes compensatory growth after pulmonary resection, mechanisms by which lung cells exhibit compensatory proliferation are not well defined. We investigated the involvement of hepatocyte growth factor (HGF) in postpneumonectomy compensatory lung regeneration in mice, because HGF has mitogenic and morphogenic actions on lung epithelial cells. Following left pneumonectomy, alveolar and airway epithelial cells underwent compensatory DNA synthesis, reaching maximal levels 5 d after the surgery. Before changes in DNA synthesis in lung epithelial cells, expression of HGF mRNA and protein levels in the remaining lung, liver, and kidney were changed in response to left pneumonectomy, and these changes were associated with postoperative increases in plasma HGF levels. c-Met/HGF receptor expression was localized predominantly in alveolar type II and

Yasushi Sakamaki; Kunio Matsumoto; Shinya Mizuno; Shinichiro Miyoshi; Hikaru Matsuda

80

cells in the presence of insulin, transferrin and fibroflast growth factor (4F medium). This

  Physics Websites

Summary: cells in the presence of insulin, transferrin and fibroflast growth factor (4F medium). This growth precursor cells might be under the control of proteolytic events for their expansion through cell multiplication. In addition to growth hormone (GH) and triiodothyronine (Tg), fetuin, a bovine fetal protein

Paris-Sud XI, Université de

81

Structural Factorization of Plants to Compute their Functional and Architectural Growth

  Physics Websites

Summary: Structural Factorization of Plants to Compute their Functional and Architectural Growth Courn`ede P simulation of plant growth has been facing a bottleneck due to the cumber- some computation implied by the complex plant topological structure. In this paper, we present a new mathematical model for plant growth

Paris-Sud XI, Université de

82

Detection of growth factor binding to gelatin and heparin using a photonic crystal optical biosensor

  Biology and Medicine Websites

Summary: Detection of growth factor binding to gelatin and heparin using a photonic crystal optical: Photonic crystal biosensor Label-free Gelatin Heparin Growth factor Drug­carrier Drug­carrier interactions timed release. A novel photonic crystal biosensor was used to investigate a gelatin­protein controlled

Cunningham, Brian

83

Targeting the Dimerization of Epidermal Growth Factor Receptors with Small-Molecule Inhibitors

  Biology and Medicine Websites

Summary: B family that also includes ErbB2 (HER2), ErbB3, and ErbB4. Binding of EGF to its receptor inducesTargeting the Dimerization of Epidermal Growth Factor Receptors with Small-Molecule Inhibitors@biochem.wustl.edu The epidermal growth factor (EGF) receptor is a receptor tyrosine kinase involved in the control of cell

Pike, Linda J.

84

Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle

  Engineering Websites

Summary: Computational Model of Vascular Endothelial Growth Factor Spatial Distribution in Muscle and Pro Members of the vascular endothelial growth factor (VEGF) family of proteins are critical regulators of VEGF in rat extensor digitorum longus skeletal muscle under in vivo conditions. Using parameters based

Popel, Aleksander S.

85

The Maize CR4 Receptor-Like Kinase Mediates a Growth Factor-Like Differentiation Response

  Biotechnology Websites

Summary: ARTICLE The Maize CR4 Receptor-Like Kinase Mediates a Growth Factor-Like Differentiation Response, cuticle for- mation, and vesicle trafficking. Some plants show tu- mor-like proliferations of cells, pattern, and differentiation sug- gesting a function analogous to growth factor responses in animals

Becraft, Philip W.

86

ORIGINAL ARTICLE Transforming growth factor-b1 induces epithelial-to-mesenchymal

  Biology and Medicine Websites

Summary: ORIGINAL ARTICLE Transforming growth factor-b1 induces epithelial-to-mesenchymal transition, fibrosis and tumor progression. Transforming growth factor-b (TGF- b) can induce simultaneously both EMT not well understood. In the present study, we show that TGF-b1 induces apoptosis and EMT in AML-12 cells

Tian, Weidong

87

Soluble Isoforms of Vascular Endothelial Growth Factor Are Predictors of Response to Sunitinib in Metastatic

  Computer Technologies and Information Sciences Websites

Summary: Soluble Isoforms of Vascular Endothelial Growth Factor Are Predictors of Response to Sunitinib analyzed, only the levels of vascular endothelial growth factor (VEGF) soluble isoforms (VEGF121 and VEGF of VEGF soluble isoforms (VEGF121/ VEGF165) was significantly associated with prognosis (P = 0

Boyer, Edmond

88

Disulfide Bond Plasticity in Epidermal Growth Factor Benedetta A. Sampoli Benitez and Elizabeth A. Komives*

  Biology and Medicine Websites

Summary: Disulfide Bond Plasticity in Epidermal Growth Factor Benedetta A. Sampoli Benitez and Elizabeth A, California ABSTRACT Epidermal growth factor (EGF) has a (1-3,2-4,5-6) disulfide-bonding pattern. This pattern and at least one EGF-like domain show that disulfide bond isomers have significant bioactivity and suggests

Komives, Elizabeth A.

89

Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis

  CiteSeer

Summary: Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A) is a multifunctional cytokine with important roles in pathological angiogenesis. Using an adenoviral vector engineered to express murine VEGF-A164, we previously investigated the steps and mechanisms by which this cytokine induced the formation of new blood vessels in adult immunodeficient mice and demonstrated that the newly formed blood vessels closely resembled those found in VEGF-A–expressing tumors. We now report that, in addition to inducing angiogenesis, VEGF-A164 also induces a strong lymphangiogenic response. This finding was unanticipated because lymphangiogenesis has been thought to be mediated by other members of the VPF/VEGF family, namely, VEGF-C and VEGF-D. The new “giant ” lymphatics generated by VEGF-A164 were structurally and functionally abnormal: greatly enlarged with incompetent valves, sluggish flow, and delayed lymph clearance. They closely resembled the large lymphatics found in lymphangiomas/lymphatic malformations, perhaps implicating VEGF-A in the pathogenesis of these lesions. Whereas the angiogenic response was maintained only as long as VEGF-A was expressed, giant lymphatics, once formed, became VEGF-A independent and persisted indefinitely, long after VEGF-A expression ceased. These findings raise the possibility that similar, abnormal lymphatics develop in other pathologies in which VEGF-A is overexpressed, e.g., malignant tumors and chronic inflammation.

Janice A. Nagy; Eliza Vasile; Dian Feng; Christian Sundberg; Lawrence F. Brown; Michael J. Detmar; Joel A. Lawitts; Laura Benjamin; Xiaolian Tan; Eleanor J. Manseau; Ann M. Dvorak; Harold F. Dvorak
2002-01-01

90

Appendix II. Calculation of Slope Factors for Naturally Occurring Radionuclides

  Environmental Sciences and Ecology Websites

Summary: -life of 5.75 y, and Th-228, with a half-life of 1.91 y. Since the naturally-occurring thorium at the uranium mines will be in equilibrium with this progeny, the thorium slope factors are calculated as the sum


91

NEURON SURVIVAL, AXON GROWTH AND THE TRANSCRIPTION FACTOR SRY-BOX CONTAINING GENE 11 (SOX11)

  Biology and Medicine Websites

Summary: NEURON SURVIVAL, AXON GROWTH AND THE TRANSCRIPTION FACTOR SRY-BOX CONTAINING GENE 11 (SOX11 of transcription factors that appear to have important roles in sensory neuron biology is the Sox family of high that overexpress either NGF or GDNF in the skin (NGF-OE and GDNF-OE mice), the transcription factor Sox11

Sibille, Etienne

92

Transduction Pathway Inhibitors on Progestin- Induced Vascular Endothelial Growth Factor Levels in Human Breast Cancer Cells

  CiteSeer

Summary: vessels, is essential for tumor growth, expansion, and metastasis (1, 2). Clinical studies have suggested that targeting angiogenesis is a useful approach for controlling the growth of breast tumors (3–7). Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic growth factors, and its effects on the proliferation, survival, and permeability of endothelial cells have been extensively studied (8, 9). VEGF165 and VEGF121 are the predominant isoforms detected in most tissues (8). Whereas both VEGF165 and VEGF121 are released from normal and tumor cells to initiate angiogenesis, First Published Online November 4, 2004

Jianbo Wu; Ra Br; Salman M. Hyder

93

Integers, without large prime factors, in arithmetic progressions, II

  Computer Technologies and Information Sciences Websites

Summary: of their distribution. Let \\Psi(x; y) be the number of integers Ÿ x that are free of prime factors ? y, \\Psi q (x; y) be the number of such integers that are also coprime to q, and \\Psi(x; y; a; q) be the number of such integers in the congruence class a (modq). Our goal is to prove that the asymptotic formula (1:1) \\Psi(x; y; a; q) ¸ \\Psi q

Bernstein, Daniel

94

Modelling hematopoiesis mediated by growth factors: Delay equations describing periodic

  Mathematics Websites

Summary: and reg- ulation of blood cells. It is based upon differentiation of stem cells under the action of growth-dependent coefficients, stability switch, Hopf bifurcation, cell population models, hematopoiesis, stem cells. 1 be observed in blood vessels, are originated from a pool of hematopoi- etic pluripotent stem cells, located

Crauste, Fabien

95

Epidermal growth factor (EGF) facilitates depilation of the Angora rabbit

  Physics Websites

Summary: to remove the angora wool by plucking was measured in 30 animals (including 6 controls) 5-8 days after with controls. Key wordy : Angora rabbit, EGF, plucking, angora wool, rabbit. I. Introduction Epidermal growth of a weakness in the fibres (MOORE et al., 1981 b, 1982 a, b). The application of EGF as a wool harvesting agent

Paris-Sud XI, Université de

96

Charge Form Factors of Quark-Model Pions II

  Nuclear Theory (arXiv)

Summary: Experimental data of the pion charge form factor are well represented by Poincar\\'e invariant constituent-quark phenomenology depending on two parameters, a confinement scale and an effective constituent--quark mass. Pion states are represented by eigenfunctions of mass and spin operators and of the light-front momenta. An effective current density is generated by the dynamics from a null-plane impulse current density. A simple shape of the wave function depending only on the confinement scale is sufficient.

F. Coester; W. N. Polyzou
2004-05-30

97

Gene Transfer of the Vascular Endothelial Growth Factor Receptor flt-1 Suppresses Pulmonary Metastasis Associated with Lung Growth

  CiteSeer

Summary: Growth of solid tumor metastases is critically dependent on angiogenesis. We hypothesized that an “angiogenic-rich ” milieu, as in pneumonectomy-induced lung growth, would be conducive to growth of pulmonary metastases, and that transfer of an antiangiogenic gene would suppress tumor growth. Two weeks after left pneumonectomy in BALB/c mice, right lung mass increased 1.5-fold compared with controls (P ? 0.0001). Our pulmonary metastases model, intravenous administration of ?-galactosidase (?gal)– marked CT26.CL25 colon carcinoma cells, resulted in diffuse metastases at 12 d after administration. However, if left pneumonectomy was performed 1 d before tumor cell administration, right lung mass was increased 1.7-fold after 12 d (P ? 0.001 compared with the right ? left lung of controls), and ?gal activity was greater (2.8-fold, P ? 0.05). To assess antiangiogenesis therapy, tumor cells were administered 1 d after pneumonectomy and 1 d later, 5 ? 10 8 plaque-forming units of Adsflt (an Ad vector expressing the extracellular portion of the flt-1 vascular endothelial growth factor [VEGF] receptor) was administered. Compared with controls, mice receiving Adsflt via intranasal or intravenous routes showed suppression of pneumonectomy-induced tumor growth (P ? 0.01, both routes compared with controls). Postpneumonectomy lung growth enhances growth of lung metastases, but this can be suppressed with Adsflt antiangiogenesis therapy.

Masahiro Mae; Timothy P. O’connor; Ronald G. Crystal

98

Role of fibroblast growth factor signalling on the regulation of embryonic stem cells 

  Edinburgh, University of - Research Archive

Summary: Fibroblast growth factor (FGF) signalling plays many fundamentally important roles during the development of the mammalian embryo. However, its effects on pluripotent stem cells derived from mouse and human embryos appear ...

Freile Vinuela, Paz
2008-01-01

99

Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue

  MIT - DSpace

Summary: Early enthusiasm over angiogenic therapy, a method to induce vascular regeneration to treat ischemic tissue with growth factors, has been tempered by a series of unsuccessful clinical trials with limited late efficacy and ...

Le, Kha N., 1973-
2009-01-01

100

Function of Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in Hepatocellular Carcinoma.

  Open Access Theses and Dissertations

Summary: ??Title of Dissertation: FUNCTION OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 7(IGFBP7) IN HEPATOCELLULAR CARCINOMA By Dong Chen. Purpose: Hepatocellular carcinoma (HCC) is a highly virulent… (more)

Chen, Dong
2012-01-01

101

Factors influencing the growth of intensively reared kids from birth to twelve weeks of age

  Computer Technologies and Information Sciences Websites

Summary: essential to obtain a knowledge of the factors influencing growth and the present study was undertaken to farmers and to upgrade the indigenous breeds of goats in the country. Indigenous breeds are excluded from

Boyer, Edmond

102

Effects of cellular and tissue pharmacokinetics on control released growth factors

  MIT - DSpace

Summary: Aim: To examine the effects of cellular and tissue pharmacokinetics on control released growth factors. Motivation: The resurgence of interest in controlled drug delivery reflects the increasing appreciation of the importance ...

Wu, David, 1973-
2001-01-01

103

Experimental and computational analysis of epidermal growth factor receptor pathway phosphorylation dynamics

  MIT - DSpace

Summary: The epidermal growth factor receptor (EGFR, also known as ErbB 1) is a prototypical receptor tyrosine kinase (RTK) that activates multi-kinase phosphorylation cascades to regulate diverse cellular processes, including ...

Kleiman, Laura B
2010-01-01

104

Microenvironmental Stiffness Enhances Glioma Cell Proliferation by Stimulating Epidermal Growth Factor Receptor Signaling

  MIT - DSpace

Summary: The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with profound tissue stiffening and genomic lesions in key members of the epidermal growth factor receptor (EGFR) pathway. Previous studies ...

Umesh, Vaibhavi

105

The role of nerve growth factor and p75 neurotrophin receptor in recovery from liver fibrosis.

  Open Access Theses and Dissertations

Summary: ??Rodent hepatic myofibroblasts are susceptible to nerve growth factor-mediated apoptosis through p75 neurotrophin receptor ligation. Hepatic myofibroblast apoptosis is critical to resolution of liver fibrosis.… (more)

Kendall, Timothy J.
2008-01-01

106

Transforming growth factor-beta receptor signalling is modulated by integrin-linked kinase.

  Open Access Theses and Dissertations

Summary: ??Transforming growth factor-beta 1 (TGF-?1) modulates regeneration after injury through induction of fibroblast proliferation, migration, and differentiation into myofibroblasts. Induction of myofibroblast differentiation by TGF-?1… (more)

Boo, Stellar H
2013-01-01

107

Novel recombinant protein constructs for improved insulin-like growth factor-1 delivery

  MIT - DSpace

Summary: Four novel recombinant protein constructs were designed to improve the delivery of insulin-like growth factor-1 (IGF-1). The IGF-1 sequence was subcloned into a HisMax plasmid and expressed at low levels by transient ...

Was, Adam (Adam S.)
2006-01-01

108

Maturation stages of mouse dendritic cells in growth factor–dependent long-term cultures

  CiteSeer

Summary: The signals controlling the checkpoints of dendritic cells (DC) maturation and the correlation between phenotypical and functional maturational stages were investigated in a defined model system of growth factor–dependent immature mouse DC. Three sequential stages of DC maturation (immature, mature, and apoptotic) were defined and characterized. Immature DC (stage 1) had low expression of costimulatory molecules, highly organized cytoskeleton, focal adhesion plaques, and slow motility; accordingly, they were very efficient in antigen uptake and processing of soluble proteins. Further, at this stage most of major histocompatibility complex class II molecules were within cytoplasmic compartments consistent with a poor allostimulatory capacity. Bacteria or cytokines were very efficient in inducing progression from stage 1 towards stage 2 (mature). Morphological changes were observed by confocal analysis including depolymerization of F-actin and loss of vinculin containing adhesive structures which correlates with acquisition of high motility. Antigen uptake and presentation of native protein antigen was reduced. In contrast, presentation of immunogenic peptides and allostimulatory activity became very efficient and secretion of IL-12 p75 was detectable after antigen presentation. This functional DC maturation ended by apoptotic cell death, and no reversion to the immature

Claudia Winzler; Patrizia Rovere; Maria Rescigno; Francesca Granucci; Luciano Adorini; Valerie S. Zimmermann; Jean Davoust; Paola Ricciardi-castagnoli
1997-01-01

109

5022 Biochemistry 1983, 22, 5022-5028 Conversion of Nerve Growth Factor-Receptor Complexes to a Slowly

  Biology and Medicine Websites

Summary: 5022 Biochemistry 1983, 22, 5022-5028 Conversion of Nerve Growth Factor-Receptor Complexes to a Slowly Dissociating, Triton X-100 Insoluble State by Anti Nerve Growth Factor Antibodied Ronald D. Vale and Eric M. Shooter* ABSTRACT: Two populations of nerve growth factor (NGF) receptors can be distinguished

Vale, Ronald D.

110

Searching for Rare Growth Factors Using Multicanonical Monte Carlo Methods Author(s): Tobin A. Driscoll and Kara L. Maki

  Mathematics Websites

Summary: -164] to construct examples of n x n matrices having any growth factor up to the maximum of 2n-1, the weightSearching for Rare Growth Factors Using Multicanonical Monte Carlo Methods Author(s): Tobin AIndustrialandAppliedMathematics Vol.49,No. 4, pp.673-692 Searching forRare Growth Factors Using Multicanonical Monte Carlo Methods

Driscoll, Toby

111

Genetic and environmental factors affecting growth characters of Charolais cattle in Southeastern Brazil

  Texas A&M University - TxSpace

Summary: G=NETIC AND ENVIRONMENTAL FACTORS AFFECTING GROWTH CHARACTERS OF CHAROLAIS CATTLE IN SOUTHEASTERN BRAZIL A Thesis by PEDRO FRANKLIN BARBOSA Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE December 1982 Major Subject: Animal Breeding GENETIC AND ENVIRONMENTAL FACTORS AFFECTING GROWTH CHARACTERS OF CHAROLAIS CATTLE IN SOUTHEASTERN BRAZIL A Thesis by PEDRO FRANKLIN BARBOSA Approved as to style and content...

Barbosa, Pedro Franklin
1982-01-01

112

Cytokine & Growth Factor Reviews 12 (2001) 245257 Molecular piracy of Kaposi's sarcoma associated herpesvirus

  Biology and Medicine Websites

Summary: Cytokine & Growth Factor Reviews 12 (2001) 245­257 Survey Molecular piracy of Kaposi's sarcoma pathways, which include interferon-mediated anti-viral responses, cytokine-regulated cell growth, apoptosis herpesvirus; Molecular piracy; Oncoprotein; Signal transduction; Immune evasion; Viral cytokine homologs

Damania, Blossom

113

Factors affecting the direction of growth of tree roots M.P. Coutts

  Physics Websites

Summary: Factors affecting the direction of growth of tree roots M.P. Coutts Forestry Commission, Northern of the main roots of a tree is an important determinant of the form of the root system. It affects the way and for cultivation systems which can influence tree growth and anchorage. This review discusses the way in which root

Paris-Sud XI, Université de

114

Contribution to growth and increment analysis on the Italian CONECOFOR Level II Network

  CiteSeer

Summary: The paper deals with the "Estimation of growth and yield " included in the National Programme on Intensive Monitoring of Forest Ecosystems CONECOFOR Aims of the paper are: i) to outline the composition and design of Level II PMPs network, also examining the structural characteristics of forest stands; ii) to describe the contents of mensurational surveys carried out in winter 1996/97 and 1999/00; iii) to analyse the growth rates in progress at each PMP using selected descriptors. Stand origin (11 high forests and 13 stored coppices and transitory crops) and the number of forest types tested are focused as the main discriminants of the PMPs network. This composition, together with irregular forestry practice, results in a number of consequences (prevailing age classes, tree densities and related stand structures, growth patterns) which cause a high in-and-between variability of all growth parameters. For the purposes of this analysis, the network of the plots was divided into three main sets: broadleaved high forest (i.e. beech stands), 6 PMPs; coniferous forest (i.e. Norway spruce stands), 5 PMPs; coppice forest (i.e. deciduous and evergreen oaks, beech and hardbeam stands), 13 PMPs. The measurement of basic growth variables (dbh and tree height) was used to describe the tree populations in each PMP; the calculation of basal area, mean and top dbh, mean and top height, provided the reference dataset at each inventory. The assessment of social class according to Kraft gave information on vertical stand structure and made it possible to analyse growth according to tree layers. Data comparison provided increments in the interval 1997-2000. The occurrence of natural mortality and ingrowth was also assessed to take into account their combined effect on tree population dynamics. No trend

Gianfranco Fabbio; Emilio Amorini

115

Regulation of Growth Anisotropy in Well-Watered and Water-Stressed Maize Roots. II. Role of Cortical Microtubules

  Environmental Sciences and Ecology Websites

Summary: Regulation of Growth Anisotropy in Well-Watered and Water-Stressed Maize Roots. II. Role of alignment of cortical microtubules or cellulose microfibrils. Previously, for the primary root of maize (Zea

Baskin, Tobias

116

The growth factor of matter perturbations in an f(R) gravity

  General Relativity & Quantum Cosmology (arXiv)

Summary: The growth of matter perturbations in the $f(R)$ model proposed by Starobinsky is studied in this paper. Three different parametric forms of the growth index are considered respectively and constraints on the model are obtained at both the $1\\sigma$ and $2\\sigma$ confidence levels, by using the current observational data for the growth factor. It is found, for all the three parametric forms of the growth index examined, that the Starobinsky model is consistent with the observations only at the $2\\sigma$ confidence level.

Xiangyun Fu; Puxun Wu; Hongwei Yu
2010-12-10

117

-Catenin Mediates Mechanically Regulated, Transforming Growth Factor-1Induced Myofibroblast Differentiation of

  Engineering Websites

Summary: and recruitment of other transcriptional factors to regulate transcriptional responses.13­16 A signaling pathway-Catenin Mediates Mechanically Regulated, Transforming Growth Factor- 1­Induced Myofibroblast cardiovascular diseases.1 A hallmark of CAVD is increased myofibroblast differentiation of valve inter- stitial

Simmons, Craig A.

118

A minor fraction of basic fibroblast growth factor mRNA is deaminated in Xenopus stage VI

  Biology and Medicine Websites

Summary: A minor fraction of basic fibroblast growth factor mRNA is deaminated in Xenopus stage VI maturation. We previously demonstrated that a cytoplasmic double-stranded RNA (dsRNA) binding factor(s), cyto transcripts of basic fibroblast growth factor (bFGF), is protected in a similar manner. Consistent

Bass, Brenda L.

119

ELECTRON MICROSCOPE STUDIES OF THE MECHANISM OF NUCLEATION AND GROWTH OF Cu Au II FROM THE DISORDERED STATE

  Computer Technologies and Information Sciences Websites

Summary: 846. ELECTRON MICROSCOPE STUDIES OF THE MECHANISM OF NUCLEATION AND GROWTH OF Cu Au II FROM the electron microscope. The alloy is disordered by annealing at 450 °C, and the nucleation and growth with the electron microscope by Ogawa and al. [1], and subsequently by Pashley and co-workers [2], [3], [4

Boyer, Edmond

120

Growth hormones. II. Structure—function relationships N. Chne J. Martal P. de la Llosa J. Charrier

  Physics Websites

Summary: Review Growth hormones. II. Structure—function relationships N. Chêne J. Martal P. de la-en-Josas, France; 2 Laboratoire des Hormones polypeptidiques, CNRS, 91118 Gif sur-Yvette, France; 3 Station de-9-1988) Summary ― Localization of the somatotropic activity of growth hormones from several species

Paris-Sud XI, Université de

121

Study of epidermal growth factor-mediated growth inhibition of MDA-468 human breast cancer cells : a role for the tumour suppressor p53 in cell cycle arrest.

  Open Access Theses and Dissertations

Summary: ??Epidermal growth factor (EGF), in pharmacological concentrations, inhibits the cellular proliferation of MDA-468 human breast cancer cells. In this study, we characterized this unusual phenomenon… (more)

Prasad, Nagendra
1994-01-01

122

The epidermal growth factor receptor as a target for therapy in breast carcinoma. Breast Cancer Res

  CiteSeer

Summary: Epidermal growth factor (EGF) receptors are expressed at high levels in about one third of epithelial cancers, and autocrine activation of EGF receptors appears to be critical for the growth of many tumors. We hypothesized that blockade of the binding sites for EGF and transforming growth factor-? on EGF receptors with an antireceptor monoclonal antibody (mAb) might be an effective anti-cancer therapy. We produced murine mAb 225against EGF receptors and demonstrated blockade of receptor function, as well as inhibition of cell growth in cultures and in nude mouse xenografts. mAb C225is the human:murine chimeric version of mAb 225. Cell cycle inhibition occurred in G1 phase, and was due to upregulation of p27Kip1, resulting in inhibition of cyclin E/cyclin dependent kinase-2 activity and hypophosphorylation of Rb. In addition, the amount and/or activities of a number of proapoptotic molecules were enhanced. The antitumor activity in vivo against xenografts was at least partly attributable to reduced vascularization, resulting from decreased vascular endothelial growth factor and basic fibroblast growth factor production by the tumor cells. Metastasis of xenografts was curtailed with mAB C225treatment, accompanied by a decrease in tumor production of MMP-9. Further studies showed that mAbs 225and C225enhanced the cytotoxicity of chemotherapy against xenografts of a

J Mendelsohn
1994-01-01

123

Original article Insulin-like growth factorI during growth in bulls

  Physics Websites

Summary: , 1985). Exogenous GH stimulates growth of the skeleton, of muscle tissue, of the intestinal tract on the skeleton are mostly mediated by IGF1 (Froesch et al., 1986), but not exclusively (isaksson et ' al., 1982). In humans, blood concentrations of IGF, increase . from birth up to puberty (Zapf et al., 1981) and decrease

Paris-Sud XI, Université de

124

Plateletderived growth factor is chemotactic for fibroblasts. J Ce ll Bio l

  CiteSeer

Summary: ABSTRACT Chemotaxis assays in modified Boyden chambers were used to detect fibroblast chemoattractants in materials released from early-stage inflammatory cells, namely, mast cells, platelets, and neutrophils. Strong attractant activity was found in substances released from platelets. This activity was accounted for mainly by the platelet-derived growth factor (PDGF), which is released from the platelets and which was active as a chemoattractant at 0.5-1.0 mitogenic units/ml. The mitogenic activity of purified PDGF, measured by [3H]thymidine incorporation, occurs at a similar concentration range. By varying the gradient of PDGF, we demonstrated that PDGF stimulates chemotaxis rather than random motility. Preincubation of suspensions of fibroblasts in the presence of PDGF decreased the subsequent migration of cells to a gradient of PDGF as well as to a gradient of fibronectin, which is also an attractant for fibroblasts. The chemotactic response of fibroblasts to PDGF was not inhibited by hydroxyurea or azidocytidine but was inhibited by actinomycin D and cycloheximide, suggesting that synthesis of RNA and proteins but not of DNA is required for the chemotactic response to occur. Fibroblast growth factor, epidermal growth factor, nerve growth factor, and insulin were not chemotactic for human skin fibroblasts, suggesting that the chemoattractant activity of PDGF for fibroblasts is not a general property of growth factors and mitogens. These results suggest that PDGF could have

Heikki Seppa; Gary Grotendorst; Silja Seppa; Elliott Schiffmann; George R Martin
1982-01-01

125

Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation

  University of California eScholarship Repository

Summary: growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrixMatrix Metalloproteinase-9 after Vascular Endothelial Growth Factormatrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor


2006-01-01

126

An inhibitor of the EGF receptor family blocks myeloma cell growth factor activity of HB-EGF and potentiates

  Physics Websites

Summary: previously found that some myeloma cell lines express the heparin-binding epidermal growth factor-like growth, particularly by monocytes and stromal cells, but not by purified primary myeloma cells. 6/9 myeloma cell lines lines, through the PI-3K/AKT pathway. A pan-ErbB inhibitor blocked the myeloma cell growth factor

Paris-Sud XI, Université de

127

Baroclinic Vorticity Production in Protoplanetary Disks; Part II: Vortex Growth and Longevity

  CERN Preprints

Summary: The factors affecting vortex growth in convectively stable protoplanetary disks are explored using numerical simulations of a two-dimensional anelastic-gas model which includes baroclinic vorticity production and radiative cooling. The baroclinic feedback, where anomalous temperature gradients produce vorticity through the baroclinic term and vortices then reinforce these temperature gradients, is found to be an important process in the rate of growth of vortices in the disk. Factors which strengthen the baroclinic feedback include fast radiative cooling, high thermal diffusion, and large radial temperature gradients in the background temperature. When the baroclinic feedback is sufficiently strong, anticyclonic vortices form from initial random perturbations and maintain their strength for the duration of the simulation, for over 600 orbital periods. Based on both simulations and a simple vortex model, we find that the local angular momentum transport due to a single vortex may be inward or outward, dependin...

Petersen, M R; Julien, K; Petersen, Mark R.; Stewart, Glen R.; Julien, Keith
2006-01-01

128

Adenoviral-Mediated Expression of Antisense RNA to Fibroblast Growth Factors Disrupts Murine Vascular Development

  CiteSeer

Summary: Fibroblast growth factors (FGFs) are expressed in the developing embryo and are postulated to regulate embryonic and vascular growth. The goal of this study was to elucidate the role of basic fibroblast growth factor (FGF-2) in early murine embryonic cardiovascular development in the mouse embryo. Gestation day 7.5 embryos were harvested and placed in culture, and 12 hr later replication-defective adenovirus (0.5 3 10 6 plaque forming units) encoding either b-galactosidase or antisense FGF-2 RNA was injected into the sinus venosus of the cultured embryos. Embryos receiving only replication -defective adenovirus expressing the b-ga- lactosidase gene continued to develop normally over the next 12 hr. In contrast, those receiving adenovirus encoding antisense FGF-2 RNA displayed marked morphogenetic abnormalities, including cessation of growth and abnormal yolk sac vascular development, even though the embryonic hearts continued to beat.Abnormal development of the yolk sac vasculature w...

Isabelle Leconte Jonathan; Jonathan C. Fox; H. Scott Baldwin; Clayton A. Buck; Judith; L. Swain

129

Epidermal Growth Factor Promotes a Neural Phenotype in Thymic Epithelial Cells and Enhances Neuropoietic Cytoldne Expression

  CiteSeer

Summary: Abstract. Neural crest-derived cells populate the thymus, and their coexistence with epithelial cells is required for proper organ development and T cell education function. We show here that epidermal growth factor (EGF), a major epithelial cell growth-enhancing agent, has a morphogenetic action to promote the expression of a neuronal phenotype (e.g., neurofilament expression) in cultured thymic epithelial cells that are characterized by a cytokeratin-positive epithelial cell background. The proliferation of such neurodifferentiated cells is also enhanced by EGF. Furthermore, the growth factor enhances cells that express the genes encoding the preprotachykinin A-generated neuropeptides and the bipotential neuropoietic and lymphopoietic cytokines ciliary neurotrophic factor and

Isabella Screpanti; Susanna Scarpa; Daniela Meco; Diana Beuavia; Luigi Frati; Andrea Modesti; Alberto Gulino I

130

Unidentified growth factors in the diet of chicks reared under commercial broiler production conditions

  Texas A&M University - TxSpace

Summary: sources of unidentified chick growth factors to promote growth of chicks reared under practical broiler conditions . ? . , , ....... ? 50 Investigations concerning xhe affect of con? densed fish solubles s dried whey., an antibiotic fermentation... to be re^uir^d by the chick?*. Many investigators are of the opin? ion that such substances are present in condensed fish solubles, whale solubles, fish meal, hydrolyzed whey, dried skim milk, dried brewers' yeast, and other types of yeast, distillers...

Camp, Arthur A.
1958-01-01

131

Properties of the exact analytic solution of the growth factor and its applications

  General Relativity & Quantum Cosmology (arXiv)

Summary: There have been the approximate analytic solution \\cite{Silveria} and several approximate analytic forms \\cite{0508156,Carroll,0303112} of the growth factor $D_{g}$ for the general dark energy models with the constant values of its equation of state $\\omde$ after Heath found the exact integral form of the solution of $D_{g}$ for the Universe including the cosmological constant or the curvature term. Recently, we obtained the exact analytic solutions of the growth factor for both $\\omde = -1$ or $-\\fr{1}{3}$ \\cite{SK1} and the general dark energy models with the constant equation of state $\\omde$ \\cite{SK3} independently. We compare the exact analytic solution of $D_{g}$ with the other well known approximate solutions. We also prove that the analytic solutions for $\\omde = -1$ or $-\\fr{1}{3}$ in Ref. \\cite{SK1} are the specific solutions of the exact solutions of the growth factor for general $\\omde$ models in Ref. \\cite{SK3} even though they look quite different. We scrutinize the issue of using the well known parameterizations of the growth index and its parameter given in Ref. \\cite{WS} to obtain the growth factor for general dark energy models. We also investigate the possible extensions of the exact solution of $D_{g}$ to the time-varying $\\omde$ for the comparison with observations.

Seokcheon Lee; Kin-Wang Ng
2010-08-25

132

Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells.

  Computer Technologies and Information Sciences Websites

Summary: , in particular as the coreceptor of heparin-binding growth factors. We previously found that heparin. As amphiregulin (AREG) is another heparin-binding factor of the EGF family, we investigated its role in multiple as a coreceptor for heparin-binding growth factors and chemokines (Couchman, 2003; Rapraeger, 2000

Boyer, Edmond

133

Leukemia . Author manuscript Insulin is a potent myeloma cell growth factor through insulin/IGF-1 hybrid

  Computer Technologies and Information Sciences Websites

Summary: , Monoclonal ; pharmacology ; Cell Division ; drug effects ; Cell Line, Tumor ; Cell Survival ; drug effects ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Growth Substances ; pharmacology ; Humans ; Insulin ; genetics ; pharmacology ; Insulin-Like Growth Factor I ; pharmacology ; physiology ; Kinetics

Boyer, Edmond

134

Regulation of Cell Growth and Differentiation within the Context of Nuclear Architecture by the Runx2 Transcription Factor: a Dissertation.

  Open Access Theses and Dissertations

Summary: ??The Runx family of transcription factors performs an essential role in animal development by controlling gene expression programs that mediate cell proliferation, growth and differentiation.… (more)

Young, Daniel W
2005-01-01

135

Mapping of the TGF-[beta] 1 binding domain of CD109, a novel transforming growth factor beta accessory receptor.

  Open Access Theses and Dissertations

Summary: ??Transforming Growth Factor Beta (TGF-beta) is a multifunctional cytokine with a broad spectrum of effects including cellular proliferation, differentiation, and extracellular matrix production. Dysregulation of… (more)

Soe-Lin, Hahn.
2006-01-01

136

PLGA microsphere formulations for sustained local delivery of vascular endothelial growth factor: considerations for therapeutic angiogenesis of infarcted myocardium.

  Open Access Theses and Dissertations

Summary: ??PLGA microspheres were developed as an injectable depot for sustained, local delivery of vascular endothelial growth factor (VEGF) in infarcted myocardium. Cryogenic solid entrapment, solvent… (more)

Anderl, Jeffrey Neil
2006-01-01

137

Investigating the dose-dependent signalling of Transforming Growth Factor-Beta in bovine aortic endothelial cells .

  Open Access Theses and Dissertations

Summary: ??Transforming growth factor-beta (TGF?) is an important signaling molecule that regulates several cellular processes including angiogenesis. However, its effects on angiogenesis are complex, with it… (more)

Richard, Amy
2012-01-01

138

Keratinocyte growth factor signalling: a mathematical model of dermalepidermal interaction in epidermal wound healing

  Environmental Sciences and Ecology Websites

Summary: in epidermal wound healing Helen J. Wearing *, Jonathan A. Sherratt Centre for Theoretical Modelling of their therapeutic value is essential to achieve improved wound healing. Keratinocyte growth factor (KGF) seems cells, yet acts exclusively on epithelial cells. In this paper, we study KGF's role in epidermal wound

Rohani, Pejman

139

Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis

  Biology and Medicine Websites

Summary: Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis) is an endothelial cell-specific angiogenic protein suspected to be involved in the pathogenesis of endometriosis between the SNPs in the VEGF region and endometriosis. To further investigate the reported association

Nyholt, Dale R.

140

JOURNAL OF CELLULAR PHYSIOLOGY 171:125134 (1997) Effect of Cell Density and Growth Factors

  Biology and Medicine Websites

Summary: JOURNAL OF CELLULAR PHYSIOLOGY 171:125­134 (1997) Effect of Cell Density and Growth Factors on cell density in culture. Subcul- ture of confluent NRK cells to 1/30 of the confluent cell density increases with increasing cell density and eventually attains a level of expression per cell at five days

Price, Paul A.

141

Modelling and Asymptotic Stability of a Growth Factor-Dependent Stem Cells

  Physics Websites

Summary: differentiate and divide, so as to produce blood cells. Growth factors act at different levels, differential equations, distributed delay, asymptotic sta- bility, Lyapunov function, Hopf bifurcation, blood cells committed to one blood cell lin- eage: white cells, red blood cells or platelets) and self

Paris-Sud XI, Université de

142

A R T I C L E Structural basis for inhibition of the epidermal growth factor

  Biology and Medicine Websites

Summary: (RTKs) amphiregulin (AR), betacellulin (BTC), epigen (EPN), epiregulin of the epidermal growth factor with such inhibitory properties was devel- oped 20 years ago by immunizing mice with human A431 epi-and Hynes, 2004; Mendelsohn, 1988). For one of these antibodies, mAb 225, a human:murine chimeric version was produced

Utrecht, Universiteit

143

Author's personal copy Effect of environmental factors on survival and growth of quahog parasite

  Biology and Medicine Websites

Summary: that temperature and salinity affect QPX distribution and/or associated disease development were previously Thraustochytrid Growth Survival In vitro Environmental factors Temperature Salinity Oxygen a b s t r a c t Quahog parasite unknown (QPX) is a protistan microorganism associated with mass mortalities of hard clams


144

The Prostate 66:779 ^787 (2006) Vascular Endothelial Growth Factor Productionin

  Biology and Medicine Websites

Summary: The Prostate 66:779 ^787 (2006) Vascular Endothelial Growth Factor Productionin Human Prostate-Lipoxygenase (P12-LOX) expression is associated with advanced stage and grade prostate cancer stimulation of signal transduction in prostate cancer cell lines following exposure to 12(S)-HETE. RESULTS. P

Jankun, Jerzy

145

Formulae for Growth Factors In Expanding Universes Containing Matter and a Cosmological Constant

  Astrophysics (arXiv)

Summary: Formulae are presented for the linear growth factor D/a and its logarithmic derivative dlnD/dlna in expanding Friedmann-Robertson-Walker Universes with arbitrary matter and vacuum densities. The formulae permit rapid and stable numerical evaluation. A fortran program is available at http://casa.colorado.edu/~ajsh/growl/ .

A. J. S. Hamilton
2001-01-25

146

Mammalian Transforming growth factor-bs: Smad signaling and physio-pathological roles

  Physics Websites

Summary: disorders. 2. Structure and Signaling The three mammalian TGF-bisoforms, TGF-b1, TGF-b2 and TGF-b3, encoded receptors that activate transcription factors of the Smad family. 1. Introduction The Transforming Growth into a mature form for receptor binding and subsequent activation of signal transduction pathways (Figure 1

Paris-Sud XI, Université de

147

Huntingtin-associated Protein 1 Interacts with Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate and

  Biology and Medicine Websites

Summary: Huntingtin-associated Protein 1 Interacts with Hepatocyte Growth Factor-regulated Tyrosine Kinase-regulated tyrosine kinase sub- strate (Hrs), a mammalian homologue of yeast vacuolar protein sorting protein Vps27p to the late endocytic compartments. Huntington's disease (HD)1 is a neurodegenerative disorder caused

Li, Lian

148

Hepatic differentiation of human embryonic stem cells on growth factor-containing surfaces

  Materials Science Websites

Summary: Hepatic differentiation of human embryonic stem cells on growth factor-containing surfaces Mahboobe and Biotechnology (NIGEB), Tehran, Iran Abstract Embryonic stem cells (ESCs) hold considerable promise in tissue). Pluripotent human embryonic stem cells (hESCs) are expected to improve accessibility to a variety of human

Revzin, Alexander

149

Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor*

  Biology and Medicine Websites

Summary: of yeast vac- uolar protein sorting (Vps) protein Vps27p; however, the role of Hrs in lysosomal trafficking homologue of yeast Vps5p that recognizes the lysosomal targeting code of epidermal growth factor receptor (EGFR) and partici- pates in lysosomal trafficking of the receptor. Biochem- ical analyses demonstrate

Li, Lian

150

Nanosize effect on the hygroscopic growth factor of aerosol particles G. Biskos,1

  Environmental Sciences and Ecology Websites

Summary: mobility diameters of 6 to 60 nm were measured using a tandem nano-Differential Mobility AnalyzerNanosize effect on the hygroscopic growth factor of aerosol particles G. Biskos,1 L. M. Russell,2 P impurities. Citation: Biskos, G., L. M. Russell, P. R. Buseck, and S. T. Martin (2006), Nanosize effect

Russell, Lynn

151

Expression of paracrine growth factors and their receptors in the ovine uterus

  Texas A&M University - TxSpace

Summary: . . . Endocrinology of estrous cycle and pregnancy. . . . . Ungulate uterine development. Ovarian steroids and receptors. . . . . . . . . . . . . . . . . . . . . . . . , . . . . . Growth factors and receptors... and development and differentiated functions that support the establishment and maintenance of pregnancy. Effects of these steroid hormones on uterine cells are mediated through receptors for progesterone receptors (PR) and estrogen receptors (ER) present...

Chen, Chen
2012-06-07

152

Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search-Projection

  Computer Technologies and Information Sciences Websites

Summary: Prediction of Inhibitory Activity of Epidermal Growth Factor Receptor Inhibitors Using Grid Search kinase (PTK) is an important protein target for anti-tumor drug discovery. To identify potential EGFR inhibitors, we conducted a quantitative structure­activity relationship (QSAR) study on the inhibitory

Zhang, Yang

153

Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs

  Biology and Medicine Websites

Summary: B) family of receptor tyrosine kinases plays an important role in regulating normal and oncogenic cellular physiology. While structures of isolated EGFR extracellular domains and intracellular protein tyrosine kinase domains have suggested mechanisms for growth factor-mediated receptor dimerization and allosteric kinase

Springer, Timothy A.

154

Pulmonary effects of keratinocyte growth factor in newborn rats exposed to hyperoxia

  Physics Websites

Summary: Pulmonary effects of keratinocyte growth factor in newborn rats exposed to hyperoxia Marie-induced impaired alveolarization, although the pulmonary mechanisms of this protection are poorly defined dysplasia (BPD) continues to occur among 20 to 40% of survivors, and new ways for combating this disease

Paris-Sud XI, Université de

155

Engineering of the Heparin-Binding Domain of Neurotrophin-6 onto Nerve Growth Factor

  Biology and Medicine Websites

Summary: Engineering of the Heparin-Binding Domain of Neurotrophin-6 onto Nerve Growth Factor Leopold L neurotrophins. However, it is the only one which is glycosylated and which contains a heparin-binding domain variable region III reverse turn of NGF with 31 residues from the NT-6 heparin-binding domain. Introduction

Ibáñez, Carlos

156

Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and

  Biology and Medicine Websites

Summary: Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N and C terminus data to be important in folding and stability. Specific mutations within the adjacent N and C terminus -strands of FGF-1 are shown to provide a substantial increase in stability. This increase is largely

Blaber, Michael

157

The Turkey Transcription Factor Pit-1/GHF-1 Can Activate the Turkey Prolactin and Growth Hormone

  Biology and Medicine Websites

Summary: The Turkey Transcription Factor Pit-1/GHF-1 Can Activate the Turkey Prolactin and Growth Hormone by cotransfection assays and immunofluorescence staining of pituitary sec- tions. In cotransfection assays, turkey Pit-1 activated the turkey Prl, turkey GH, and rat Prl promoters 3.8-, 3.7-, and 12.5-fold

Ramachandran, Ramesh

158

INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM

  Biology and Medicine Websites

Summary: INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH concentrations and ATP and 2-Cl-ATP fully sustained survival of PC12 cells after serum deprivation. Our results and Schubert, 1998). Simi- larly, P2 receptor e¡ects in the modulation of brain dam- age still awaits further

Burnstock, Geoffrey

159

Immobilization of Growth Factors on Collagen Scaffolds Mediated by Polyanionic Collagen Mimetic Peptides and Its

  Biology and Medicine Websites

Summary: interaction. The anionic CMPs exhibited specific binding affinity to type I collagen substrates whileImmobilization of Growth Factors on Collagen Scaffolds Mediated by Polyanionic Collagen Mimetic to the survival and ultimate functional capacity of engineered tissue constructs. Here we present a new collagen

Chen, Christopher S.

160

Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study

  Physics Websites

Summary: Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II Studies ; Male ; Memory Disorders ; blood ; Middle Aged ; Odds Ratio ; Risk Factors The distinction associations of' cardiovascular disease and its risk factors with different types of dementia and lower

Paris-Sud XI, Université de

161

Growth of a Vortex Mode during Gravitational Collapse Resulting in Type II Supernova

  Astrophysics (arXiv)

Summary: We investigate stability of a gravitationally collapsing iron core against non-spherical perturbation. The gravitationally collapsing iron core is approximated by a similarity solution for dynamically collapsing polytropic gas sphere. We find that the similarity solution is unstable against non-spherical perturbations. The perturbation grows in proportion to $ (t - t_0) ^{-\\sigma} $ while the the central density increases in proportion to $ (t - t_0) ^{-2} $. The growth rate is $ \\sigma = 1/3 + \\ell (\\gamma - 4/3) $, where $ \\gamma $ and $ \\ell $ denote the polytropic index and the parameter $ \\ell $ of the spherical harmonics, $ Y_{\\ell} ^m (\\theta, \\phi) $, respectively. The growing perturbation is dominated by vortex motion. Thus it excites global convection during the collapse and may contribute to material mixing in a type II supernova.

Tomoyuki Hanawa; Tomoaki Matsumoto
2000-01-26

162

Role of vascular endothelial growth factor (VEGF) in granulosa cell function: involvement of heterotrimeric G-protein signalling pathways. 

  Edinburgh, University of - Research Archive

Summary: Vascular Endothelial Growth Factor (VEGF) has been shown to be an absolute requirement for ovarian follicle development. Although VEGF is commonly regarded primarily as an angiogenic factor, granulosa cells are a major ...

Doyle, Lynsey Kerr
2009-01-01

163

Factorization of numbers with Gauss sums: II. Suggestions for implementations with chirped laser pulses

  Quantum Physics (arXiv)

Summary: We propose three implementations of the Gauss sum factorization schemes discussed in part I of this series: (i) a two-photon transition in a multi-level ladder system induced by a chirped laser pulse, (ii) a chirped one-photon transition in a two-level atom with a periodically modulated excited state, and (iii) a linearly chirped one-photon transition driven by a sequence of ultrashort pulses. For each of these quantum systems we show that the excitation probability amplitude is given by an appropriate Gauss sum. We provide rules how to encode the number N to be factored in our system and how to identify the factors of N in the fluorescence signal of the excited state.

W. Merkel; S. Wölk; W. P. Schleich; I. Sh. Averbukh; B. Girard; G. G. Paulus
2012-10-24

164

MEASUREMENT OF ACCUARACY OF THE ADVANCED PLACEMENT EXAM FOR CALCULUS II AND THE INFLUENTIAL FACTORS TO PRECALCULUS

  Mathematics Websites

Summary: MEASUREMENT OF ACCUARACY OF THE ADVANCED PLACEMENT EXAM FOR CALCULUS II AND THE INFLUENTIAL FACTORS ---------------------------------------------------------------------------------------------- 4 CHAPTERS 1. INTRODUCTION: AP CALCULUS STUDY-------------------------------------------------- 5 2---------------------------------------------------------------------- 9. Probability of AP Calculus Grades

Miles, Will

165

Unidentified growth factors for turkey poults maintained on a synthetic diet

  Texas A&M University - TxSpace

Summary: UNIDENTII'IED GROWTH 1'ACTORS FQR TURKEY PQULTS MAINTAINED QN A SYNTHETIC DIET A Thesis EATHI M. SALAMA Submitted to the Graduate School of the Agricultural and Mechanical College of Texas in partial fulfillment of the requirements... for the degree of MASTER QE SCIENCE January 1956 Major Subjects Biochemistry and Nutrition LIIRARY B 4 M CuLLEBE 8F tEXAB UNIDENTIFIED GROWTH FACTORS FOR TURKEY POULTS IEAINTAINED ON A SYNTHETIC DIET A Thesis FATHI M. SALAMA Approved as to style...

Salama, Fathi Mahmoud
1956-01-01

166

Stress intensity factors and fatigue growth of a surface crack in a drill pipe during rotary drilling operation

  Mathematics Websites

Summary: Stress intensity factors and fatigue growth of a surface crack in a drill pipe during rotary and the fatigue growth of a circumferential semi-elliptical surface crack in a hollow cylinder subjected to rotary fatigue growth rate law. Using this model, we can study the evolution of parameters characterizing


167

Mixed-mode, high-cycle fatigue-crack growth thresholds in II. Quantication of crack-tip shielding

  Materials Science Websites

Summary: Mixed-mode, high-cycle fatigue-crack growth thresholds in Ti±6Al±4V II. Quanti®cation of crack alloy is examined under high-cycle fatigue loading conditions, i.e., at a loading frequency of 1000 Hz Science Ltd. All rights reserved. Keywords: High-cycle fatigue; Fatigue thresholds; Mixed mode; Crack

Ritchie, Robert

168

Baroclinic Vorticity Production in Protoplanetary Disks; Part II: Vortex Growth and Longevity

  Astrophysics (arXiv)

Summary: The factors affecting vortex growth in convectively stable protoplanetary disks are explored using numerical simulations of a two-dimensional anelastic-gas model which includes baroclinic vorticity production and radiative cooling. The baroclinic feedback, where anomalous temperature gradients produce vorticity through the baroclinic term and vortices then reinforce these temperature gradients, is found to be an important process in the rate of growth of vortices in the disk. Factors which strengthen the baroclinic feedback include fast radiative cooling, high thermal diffusion, and large radial temperature gradients in the background temperature. When the baroclinic feedback is sufficiently strong, anticyclonic vortices form from initial random perturbations and maintain their strength for the duration of the simulation, for over 600 orbital periods. Based on both simulations and a simple vortex model, we find that the local angular momentum transport due to a single vortex may be inward or outward, depending its orientation. The global angular momentum transport is highly variable in time, and is sometimes negative and sometimes positive. This result is for an anelastic gas model, and does not include shocks that could affect angular momentum transport in a compressible-gas disk.

Mark R. Petersen; Glen R. Stewart; Keith Julien
2006-11-16

169

Structural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin,

  Biology and Medicine Websites

Summary: of the structural integrity of hIGF-I in relation to its biological function. Human insulin-like growth factor I (hStructural Origins of the Functional Divergence of Human Insulin-Like Growth Factor-I and Insulin. Turkenburg, Frederik M. de Bree,# and Zbigniew Dauter§ Structural Biology Laboratory, Chemistry Department


170

Copyright 1999 by the Genetics Society of America stumps, a Drosophila Gene Required for Fibroblast Growth Factor (FGF)-directed

  Biology and Medicine Websites

Summary: Copyright © 1999 by the Genetics Society of America stumps, a Drosophila Gene Required for Fibroblast Growth Factor (FGF)-directed Migrations of Tracheal and Mesodermal Cells Farhad Imam,1 David, 1998 Accepted for publication February 8, 1999 ABSTRACT Fibroblast growth factors (FGFs) bind to FGF

Krasnow, Mark A.

171

Platelet-derived Growth Factor (PDGF)-induced Ca2 in the CG4 Oligodendroglial Cell Line and in Transformed

  Biology and Medicine Websites

Summary: Platelet-derived Growth Factor (PDGF)-induced Ca2 Signaling in the CG4 Oligodendroglial Cell Line induced by platelet-derived growth factor (PDGF) was investigated in the oligodendroglial cell lines CG4- duced both oscillatory and non-oscillatory Ca2 responses in CEINGE cl3 cells as well as in CG4 cells

Fatatis, Alessandro

172

doi: 10.1111/j.1469-1809.2012.00726.x Association of the Vascular Endothelial Growth Factor

  Engineering Websites

Summary: doi: 10.1111/j.1469-1809.2012.00726.x Association of the Vascular Endothelial Growth Factor Gene Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent 9052, Belgium 8 Department Summary Published data on the association between the vascular endothelial growth factor (VEGF) gene ­460C


173

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial–mesenchymal transition

  CiteSeer

Summary: Abstract. Epithelial–mesenchymal transition (EMT) is an essential morphogenetic process during embryonic development. It can be induced in vitro by hepatocyte growth factor/scatter factor (HGF/SF), or by FGF-1 in our NBT-II cell model for EMT. We tested for a central role in EMT of a zinc-finger protein called Slug. Slug mRNA and protein levels were increased transiently in FGF-1–treated NBT-II cells. Transient or stable transfection of Slug cDNA in NBT-II cells resulted in a striking disappearance of the desmosomal markers desmoplakin and desmoglein from cell–cell contact areas, mimicking the initial steps of FGF-1 or HGF/SFinduced EMT. Stable transfectant cells expressed Slug protein and were less epithelial, with increased cell spreading and cell–cell separation in subconfluent cultures. Interestingly, NBT-II cells transfected with antisense Slug cDNA were able to resist EMT induction by FGF-1 or even HGF/SF. This antisense effect was suppressed by retransfection with Slug sense cDNA. Our results indicate that Slug induces the first phase of growth factor–induced EMT, including desmosome dissociation, cell spreading, and initiation of cell separation. Moreover, the antisense inhibition experiments suggest that Slug is also necessary for EMT. Epithelial cells adhere to each other through specialized structures essential for the maintenance of epithelial organization and differentiation. Among these, structures linked to the cytokeratin intermediate filament network appear to provide the strongest and most resilient adhesion (12, 15). The core unit of such structures is the desmosome, which appears early during epithelial differentiation (13, 24, 30, 37). Desmoglein and desmocollins are desmosome-specific cadherins that mediate cell– cell binding (15, 34). They are part of a molecular complex

Pierre Savagner; Kenneth M. Yamada; Jean Paul Thiery
1997-01-01

174

Noncompetitive, Chemokine-mediated Inhibition of Basic Fibroblast Growth Factor-induced Endothelial Cell Proliferation*

  CiteSeer

Summary: The proinflammatory and chemoattractant chemokine interleukin-8 (IL-8) inhibits cell proliferation induced by basic fibroblast growth factor (bFGF) in mouse endothelial cells isolated from subcutaneous sponge implant (sponge-induced mouse endothelial cells) and in bovine aortic endothelial GM 7373 cells. The mechanism of action of IL-8 was investigated in GM 7373 cells. IL-8 did not prevent the binding of bFGF to its tyrosine kinase FGF receptors (FGFRs) nor to cell surface heparan sulfate proteoglycans (HSPGs). A transient interaction of IL-8 with the cell before the addition of the growth factor was sufficient to prevent bFGF activity. The inhibitory activity of IL-8 was abolished by protein kinase C (PKC) inhibitors and was mimicked by the PKC activator 12-O-tetradecanoylphorbol-13-acetate. Accordingly,

Richard Horuk

175

Distance, Growth Factor, and Dark Energy Constraints from Photometric Baryon Acoustic Oscillation and Weak Lensing Measurements

  Astrophysics (arXiv)

Summary: Baryon acoustic oscillations (BAOs) and weak lensing (WL) are complementary probes of cosmology. We explore the distance and growth factor measurements from photometric BAO and WL techniques and investigate the roles of the distance and growth factor in constraining dark energy. We find for WL that the growth factor has a great impact on dark energy constraints but is much less powerful than the distance. Dark energy constraints from WL are concentrated in considerably fewer distance eigenmodes than those from BAO, with the largest contributions from modes that are sensitive to the absolute distance. Both techniques have some well determined distance eigenmodes that are not very sensitive to the dark energy equation of state parameters w_0 and w_a, suggesting that they can accommodate additional parameters for dark energy and for the control of systematic uncertainties. A joint analysis of BAO and WL is far more powerful than either technique alone, and the resulting constraints on the distance and growth factor will be useful for distinguishing dark energy and modified gravity models. The Large Synoptic Survey Telescope (LSST) will yield both WL and angular BAO over a sample of several billion galaxies. Joint LSST BAO and WL can yield 0.5% level precision on ten comoving distances evenly spaced in log(1+z) between redshift 0.3 and 3 with cosmic microwave background priors from Planck. In addition, since the angular diameter distance, which directly affects the observables, is linked to the comoving distance solely by the curvature radius in the Friedmann-Robertson-Walker metric solution, LSST can achieve a pure metric constraint of 0.017 on the mean curvature parameter Omega_k of the universe simultaneously with the constraints on the comoving distances.

Hu Zhan; Lloyd Knox; J. Anthony Tyson
2008-06-05

176

Studies on the isolation of unidentified growth factors in distillers dried solubles

  Texas A&M University - TxSpace

Summary: served to precipitate the crystals, but when more ethanol was added, the precipi- tate went into solution. The material was found to be soluble in acetone, cthe , methanol, ethanol, 32 isopropanol, 57. sodium hydroxide and 5/ sodium bicarbo- nate...STUDIES ON THE ISOLATION OF UNIDENTIFIED GROWTH FACTORS IN DISTILLERS DRIED SOLUBLES A Thesis bv Terence Dixon Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER...

Dixon, Terence
2012-06-07

177

Thick collagen-based matrices including growth factors to induce 3D neural differentiation

  Physics Websites

Summary: 1 Thick collagen-based matrices including growth factors to induce 3D neural differentiation Marie-Noëlle Labour1,2,3 , Amélie Banc1,2 , Audrey Tourette1,2 , Frédérique Cunin2 , Jean-Michel Verdier1,3 , Jean-Marie Devoisselle2 , Anne Marcilhac1,3 and Emmanuel Belamie*1,2 . 1 Ecole Pratique des Hautes Etudes, 46 rue de

Paris-Sud XI, Université de

178

Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor ? 1–induced Pulmonary Fibrosis

  CiteSeer

Summary: Fibrosis and apoptosis are juxtaposed in pulmonary disorders such as asthma and the interstitial diseases, and transforming growth factor (TGF)-?1 has been implicated in the pathogenesis of these responses. However, the in vivo effector functions of TGF-?1 in the lung and its roles in the pathogenesis of these responses are not completely understood. In addition, the relationships between apoptosis and other TGF-?1–induced responses have not been defined. To address these issues, we targeted bioactive TGF-?1 to the murine lung using a novel externally regulatable, triple transgenic system. TGF-?1 produced a transient wave of epithelial apoptosis that was followed by mononuclear-rich inflammation, tissue fibrosis, myofibroblast and myocyte hyperplasia, and septal rupture with honeycombing. Studies of these mice highlighted the reversibility of this fibrotic response. They also demonstrated that a null mutation of early growth response gene (Egr)-1 or caspase inhibition blocked TGF-?1–induced apoptosis. Interestingly, both interventions markedly ameliorated TGF-?1–induced fibrosis and alveolar remodeling. These studies illustrate the complex effects of TGF-?1 in vivo and define the critical role of Egr-1 in the TGF-?1 phenotype. They also demonstrate that Egr-1–mediated apoptosis is a prerequisite for TGF-?1–induced fibrosis and remodeling. Key words: asthma • pulmonary fibrosis • fibrosis reversibility • airway remodeling

Chun Geun Lee; Soo Jung Cho; Min Jong Kang; Svetlana P. Chapoval; Patty J. Lee; Paul W. Noble; Teshome Yehualaeshet; Binfeng Lu; Richard A. Flavell; Jeffrey Milbr; Robert J. Homer; Jack A. Elias

179

Growth factor control of skeletal muscle differentiation: commitment to terminal differntiation occurs in G1 phase and is repressed by fibroblast growth factor

  CiteSeer

Summary: Abstract. Analysis of MM14 mouse myoblasts demonstrates that terminal differentiation is repressed by pure preparations of both acidic and basic fibroblast growth factor (FGF). Basic FGF is ~30-fold more potent than acidic FGF and it exhibits half maximal activity in clonal assays at 0.03 ng/ml (2 pM). FGF repression occurs only during the G ~ phase of the cell cycle by a mechanism that appears to be independent of ongoing cell proliferation. When exponentially growing myoblasts are deprived of FGF, cells become postmitotic within 2-3 h, express muscle-specific proteins within 6-7 h, and commence fusion within 12-14 h. Although expression of these three terminal differentiation phenotypes occurs at different times, all are initiated by a single regulatory "commitment " event in G~. The entire population commits to terminal differentiation within 12.5 h of FGF removal as all cells complete the cell cycle and move into Gt. Differentiation does not require a new round of DNA synthesis. Comparison of MM14 behavior with other myoblast types suggests a general model for skeletal muscle development in which specific growth factors serve the dual role of stimulating myoblast proliferation and directly repressing terminal differentiation. S KE L Ea"A L muscle development involves an initial period of myoblast replication, followed by a phase in which some myoblasts continue to proliferate while others undergo terminal differentiation. The latter process involves the permanent cessation of DNA synthesis, activation of muscle-specific gene expression, and the fusion of single cells into multinucleated muscle fibers. In vitro studies indicate that the onset of terminal differentiation is delayed by media that are rich in serum and/or embryo extract components

Christopher H. Clegg; Thomas A. Linkhart; Bradley B. Olwin; Stephen D. Hauschka
1987-01-01

180

ATP Utilization by Yeast Replication Factor C II. MULTIPLE STEPWISE ATP BINDING EVENTS ARE REQUIRED TO LOAD PROLIFERATING CELL

  Biology and Medicine Websites

Summary: ATP Utilization by Yeast Replication Factor C II. MULTIPLE STEPWISE ATP BINDING EVENTS ARE REQUIRED of adenosine (3-thiotriphosphate) (ATP S), a nonhydrolyzable analog of ATP, to replication factor C with a N-terminal truncation ( 2­273) of the Rfc1 sub- unit (RFC) was studied by filter binding. RFC alone bound 1.8 ATP

Burgers, Peter M.

181

National Industrial Hemp Strategy ii March 2008Executive Summary Growth of the Canadian Industrial Hemp Sector

  CiteSeer

Summary: The history of hemp cultivation is as old as the history of civilization. In North America, hemp was a crucial crop during the colonial period, and it continued to be produced right up to and through the Second World War. A combination of regulatory pressures and changing public perceptions around drug use led to the disappearance of domestic hemp cultivation in North America in the years following WW II. In 1998, Canada joined the large international community of hemp producers by permitting the production of industrial hemp, under a carefully monitored regulatory process. While the growth of the Canadian industrial hemp sector over the past decade has been uneven and at times fraught with challenges, as would be expected from a fledgling industry, there is considerable cause for optimism: The market for hemp seed materials for human health, nutrition, and personal care applications is strong and growing. Market price for a drum of conventionally grown hemp oil is approximately $1600 Cdn, with organic hem oil fetching in the neighbourhood of $2500 a drum (Spring 2008).

Agri-food Canada

182

Competitive signalling between TrkA and p75 nerve growth factor receptor determines cell survival

  CiteSeer

Summary: In addition to its role as a survival factor, nerve growth factor (NGF) has been implicated in initiating apoptosis in restricted cell types both during development and after terminal cell differentiation. NGF binds to the TrkA tyrosine kinase and the p75 neurotrophin receptor, a member of the tumor necrosis factor cytokine family. To understand the mechanisms underlying survival versus death decisions, the TrkA receptor was introduced into oligodendrocyte cell cultures that undergo apoptosis in a p75-dependent manner. Here we report that activation of the TrkA NGF receptor in oligodendrocytes negates cell death by the p75 receptor. TrkA-mediated rescue from apoptosis correlated with mitogen-activated protein kinase activation. Concurrently, activation of TrkA in oligodendrocytes resulted in suppression of c-jun kinase activity initiated by p75, whereas induction of NF?B activity by p75 was unaffected.

Sung Ok Yoon; Patrizia Casaccia-bonnefil; Bruce Carter; Moses V. Chao
1998-01-01

183

Kinetic model of II-VI(001) semiconductor surfaces: Growth rates in atomic layer epitaxy T. Volkmann, M. Ahr, and M. Biehl

  Computer Technologies and Information Sciences Websites

Summary: kinetics results in two different regimes: at high the growth rate is limited to ¡£¢ ¤ layers per ALE demonstrate how the surface reconstruction and limited Cd-coverage restrict the ALE growth rate at highKinetic model of II-VI(001) semiconductor surfaces: Growth rates in atomic layer epitaxy T

Biehl, Michael

184

Vascular permeability factor (vascular endothelial growth factor gene is expressed differentially in normal tissues, macrophages and tumors

  CiteSeer

Summary: Persistent microvascular hyperpermeability to plasma proteins even after the cessation of injury is a characteristic but poorly understood feature of normal wound healing. It results in extravasation of fibrinogen that clots to form fibrin, which serves as a provisional matrix and promotes angiogenesis and scar formation. We present evidence indicating that vascular permeability factor (VPF; also known as vascular endothelial growth factor) may be responsible for the hyperpermeable state, as well as the angiogenesis, that are characteristic of healing wounds. Hyperpermeable blood vessels were identified in healing split-thickness guinea pig and rat punch biopsy skin wounds by their capacity to extravasate circulating macromolecular tracers (colloidal carbon, fluoresceinated dextran). Vascular permeability was maximal at 2-3 d, but persisted as late as 7 d after wounding. Leaky vessels were found initially at the wound edges and later in the subepidermal granulation tissue as keratinocytes migrated to cover the denuded wound surface. Angiogenesis was also prominent within this 7-d interval. In situ hybridization revealed that greatly increased amounts of VPF mRNA were expressed by keratinocytes, initially those at the wound edge, and, at later intervals, keratinocytes that migrated to cover the wound surface; occasional mononuclear cells also expressed VPF mRNA. Secreted VPF was detected by immunofluoroassay of medium from

F. Brown; Kiangteck Yeo; Brygida Berse; Tet-kin Yeo; Donald R Senger; Harold F. Dvorak; Livingston Van De
1992-01-01

185

BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth

  CiteSeer

Summary: Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M–stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center–like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function. Key words: tumor necrosis factor • B lymphocytes • T lymphocytes • B cell growth • immunoglobulin G Members of the TNF cytokine family are critically involved in the regulation of inflammation, of the immune

Pascal Schneider; Fabienne Mackay; Véronique Steiner; Kay Hofmann; Jean-luc Bodmer; Nils Holler; Christine Ambrose; Pornsri Lawton; Sarah Bixler; Hans Acha-orbea; Danila Valmori; Pedro Romero; Christiane Werner-favre; Rudolph H. Zubler; Jeffrey L. Browning
1999-01-01

186

Decreased Lung Fibroblast Growth Factor 18 and Elastin in Human Congenital Diaphragmatic Hernia and Animal Models

  CiteSeer

Summary: Rationale: Lung hypoplasia in congenital diaphragmatic hernia (CDH) seems to involve impaired alveolar septation. We hypothesized that disturbed deposition of elastin and expression of fibroblast growth factor 18 (FGF18), an elastogenesis stimulus, occurs in CDH. Objectives: To document FGF18 and elastin in human CDH and ovine surgical and rat nitrofen models and to use models to evaluate the benefit of treatments. Methods: Human CDH and control lungs were collected post mortem. Diaphragmatic hernia was created in sheep at 85 days; fetal lungs were collected at 139 days (term ? 145 days). Pregnant rats received nitrofen at 12 days; fetal lungs were collected at 21 days (term ? 22 days). Some of the sheep fetuses with hernia underwent tracheal occlusion (TO); some of the nitrofen-treated pregnant rats received vitamin A. Both treatments are known to promote lung growth.

Olivier Boucherat; Ra Benachi; Anne-marie Barlier-mur; Marie-laure Franco-montoya; Jelena Martinovic; Bernard Thébaud; Bernadette Chailley-heu; Jacques R. Bourbon

187

The Functions of Myosin II and Myosin V Homologs in Tip Growth and Septation in Aspergillus nidulans

  University of Kansas - KU ScholarWorks

Summary: The Functions of Myosin II and Myosin V Homologs in Tip Growth and Septation in Aspergillus nidulans Naimeh Taheri-Talesh1, Yi Xiong2¤, Berl R. Oakley1,2* 1Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, United States... of America, 2Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, United States of America Abstract Because of the industrial and medical importance of members of the fungal genus Aspergillus, there is considerable interest...

Taheri-Talesh, Naimeh; Xiong, Yi; Oakley, Berl R.
2012-02-16

188

Colony-Stimulating Factor Activates Human Macrophages to Inhibit Growth or Kill Mycobacterium avium Complex

  CiteSeer

Summary: Organisms belonging to the Mycobacterium avium complex (MAC) are associated with life-threatening bacteremia in patients with the acquired immunodeficiency syndrome (AIDS). As these organisms survive within macrophages, we examined the ability of recombinant human granubocyte-monocyte colony-stimulating factor (GM-CSF) to acti-vate human monocyte-derived macrophages to inhibit the intracellular growth or kill the most mouse-virulent MAC strain in our collection that belongs to serotype 1. While un-stimulated cells did not inhibit intracellular growth of MAC, macrophages activated by GM-CSF (10-10 U/mi) inhibited or killed up to 58 ± 5 % of the initial inoculum. This activation was dose-dependent, with maximal change occurring with a dose of 100 U/mb after 72 hr exposure. Inhibition or killing was demonstrated if GM-CSF was given both before or after establishment of infection. The combination of GM-CSF (10 U/mI) plus TNF (10 U/mI) augmented macrophage killing (range, 31 ± 4%) compared with GM-CSF (10k U/mI) alone, but the combination of recombinant human interferon-gamma (IFN-y) plus GM-CSF resulted in a significant decrease in intracellular inhibition of growth or killing (13.3 ± 2%) compared with 57.7 ± 5 % obtained with GM-CSF alone. These results indicate that: 1) GM-CSF can activate macrophages to inhibit intracellular growth or kill MAC; 2) killing may be augmented by TNF; and 3) lFNy may impair GM-CSF-dependent macrophage activation. Key words: recombinant human tumor necrosis factor (TNF), recombinant human inter-feron-gamma (IFN-y), cytokines, opportunistic infection, intracellular killing

Recombinant Granulocyte-macrophage; Luiz Eduardo; M. Bermudez; Lowell S. Young

189

2D protrusion but not motility predicts growth factor–induced cancer cell migration in 3D collagen

  MIT - DSpace

Summary: Growth factor–induced migration is a critical step in the dissemination and metastasis of solid tumors. Although differences in properties characterizing cell migration on two-dimensional (2D) substrata versus within ...

Meyer, Aaron Samuel

190

Revision to "1-x-3 Tandem Differential Mobility Analyzer for Measurement of the Irreversibility of the Hygroscopic Growth Factor"

  Environmental Management and Restoration Websites

Summary: are attributable to instrumental gradients of 1 to 2% RH. For example, an efflorescence test is susceptible near-:CPC0 would depend not on a phase transition but instead on a difference in growth factors at (RH0


191

Chronic Activation of Wild-Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

  MIT - DSpace

Summary: Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven ...

Whittaker, Charles A.

192

Multivariate Perturbation of a Growth Factor-Cytokine Signalling Network Reveals Complex Systemic Responses in Glioblastoma Cells

  MIT - DSpace

Summary: Glioblastoma cells can evade TRAIL-induced apoptosis through various strategies involving the growth factor-activated MEK–MAPK/ERK and PI3K–Akt/PKB pro-survival signalling cascades. Although these signalling cascades have ...

Tang, Yew Chung

193

II. Types of LithographyII. Types of Lithography A. Photolithography (optical, UV, EUV) F. Step Growth

  Materials Science Websites

Summary: Growth B. E-beam/ion-beam lithography C. X-ray lithography G. Nanoimprint H. Shadow Mask D. Interference Liu, UCD Phy250-1, 2011, NanoFab26 #12;IIII--D. Interference LithographyD. Interference Lithography.I. Smith, M. Hwang, C.A. Ross, J. Appl. Phys. 85 (1999) 6160. #12;XX--ray Interference Lithographyray

Liu, Kai

194

Molecular Cell, Vol. 12, 271280, August, 2003, Copyright 2003 by Cell Press ReviewIntegration of Growth Factor

  Biology and Medicine Websites

Summary: Research Center Massachusetts General Hospital factor 4E (eIF4E) binding protein (4EBP1) and the S6 02115 the growth factor signals upstream of 4EBP1 and S6K1, such as loss of the tumor suppressor PTEN aswork, which converges on effectors such as 4EBP1 and S6K1, leads to growth by promoting protein syn

Nghiem, Paul

195

Involvement of Src and Epidermal Growth Factor Receptor in the Signal-transducing Function of Na /K -ATPase*

  Biology and Medicine Websites

Summary: Involvement of Src and Epidermal Growth Factor Receptor in the Signal-transducing Function of Na /K, causing partial inhibition of the cardiac myocyte Na /K -ATPase, in- duce hypertrophy and several growth-related genes through signal pathways that include the activation of Ras and p42/44 mitogen-activated protein

Brand, Paul H.

196

Identification of a T cell-derived B cell growth factor distinct from interleukin

  CiteSeer

Summary: The importance of murine monokines and lymphokines in T cell immune responses has been emphasized by the development of T cell cloning technology (1) and the identification of cloned tumor lines that respond to or secrete these factors (2, 3). Such studies have shown that the monokine interleukin 1 (IL-1) 1 induces certain T cells to secrete interleukin 2 (IL-2), and that this lymphokine can maintain continuous in vitro proliferation of some T cell subsets. In contrast, the interaction of monokines and lymphokines with B cells is poorly understood, partly because of the lack of assays for B cell function in which contaminating accessory cells capable of mediating secondary effects have been excluded. We have recently described a procedure for the long-term culture of normal mouse B lymphocytes in which induced supernatants from a T cell hybridoma sustain slow proliferation of lipopolysaccharide-activated B cells for periods of up to 12 mo (4). This procedure implied the existence of a T cellderived growth factor that interacts with activated B lymphocytes to maintain proliferation. Here we identify such a factor in induced supernatants from the mouse thymoma EL4. This material is distinct from previously recognized factors, including

Maureen Howard; John Farrar; Mary Hilfiker; Barbara Johnson; Kiyoshi Takatsu; Toshiyuki Hamaoka; William E. Paul
1982-01-01

197

Controllable growth and photovoltaic applications of group II-VI semiconductor nanomaterials.

  Open Access Theses and Dissertations

Summary: ???Group II-VI semiconductors with ordered nanostructure arrays or higher level nanoarchitectures are expected to not only have enhanced applications in electromagnetic, optical, and green energy… (more)

Luan, Chunyan (???)
2012-01-01

198

Original article Plasma levels of growth hormone

  Physics Websites

Summary: Original article Plasma levels of growth hormone and insulin-like growth factor-I and -II from 2 of the somatotrophic hormones of 2 genetic lines of broiler chickens selected for 6-wk body weight (GL (FC-line). Blood samples were collected weekly and analysed for growth hormone (GH) and insulin

Paris-Sud XI, Université de

199

1Economic Progress as Cancer Risk Factor II. Why is Overall Cancer Risk Higher in More Developed Countries?

  CiteSeer

Summary: © Copyright is held by the authors. Working papers of the Max Planck Institute for Demographic Research receive only limited review. Views or opinions expressed in working papers are attributable to the authors and do not necessarily reflect those of the Institute. Economic progress as cancer risk factor II. Why is overall cancer risk higher in more developed countries?

Svetlana V. Ukraintseva; Anatoly I. Yashin
2005-01-01

200

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

  Biology and Medicine Websites

Summary: Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator their size. The target of rapamycin (TOR) is an evolutionarily conserved kinase that integrates signals from and cell cycle progression coordi- nately. In mammals, TOR is best known to regulate translation through


201

Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes

  CiteSeer

Summary: The survival, differentiation, and maintenance of responsive neurons are regulated by nerve growth factor (NGF), which is secreted by the target and interacts with receptors on the axon tip. It is uncertain how the NGF signal is communicated retrogradely from distal axons to neuron cell bodies. Retrograde transport of activated receptors in endocytic vesicles could convey the signal. However, little is known about endocytosis of NGF receptors, and there is no evidence that NGF receptors continue to signal after endocytosis. We have examined early events in the membrane traffic of NGF and its receptor, gp140 TrkA (TrkA), in PC12 cells. NGF induced rapid and extensive endocytosis of TrkA in these cells, and the receptor subsequently moved into small organelles located near the plasma membrane. Some of these organelles contained clathrin and ?-adaptin, which implies that TrkA is internalized by clathrinmediated

Mark L. Grimes; Jie Zhou; A Eric C. Beattie; A Eric C. Yuen; Deborah E. Hall; Janice S. Valletta; Jennifer H. Lavail; Nigel W. Bunnett; William C. Mobley
1996-01-01

202

Insulin-Like Growth Factor-1 Inhibits Mature Oligodendrocyte Apoptosis during Primary Demyelination

  CiteSeer

Summary: Metabolic insult results in apoptosis and depletion of mature oligodendrocytes during demyelination. To examine the role of insulin-like growth factor-1 (IGF-1) during acute demyelination and remyelination in the adult CNS, we exposed transgenic mice that continuously express IGF-1 (IGF-1 tg) to cuprizone intoxication. Demyelination was observed within the corpus callosum in both wild-type and IGF-1 tg mice 3 weeks after exposure to cuprizone. Wild-type mice showed significant apoptotic mature oligodendrocytes and a dramatic loss of these cells within the lesion that resulted in near complete depletion and demyelination by week 5. In contrast, the demyelinated corpus callosum of the IGF-1 tg mice was near full recovery by week 5. This rapid recovery was apparently caused by survival of the mature oligodendrocyte population because apoptosis was negligible, and by week 4, the mature oligodendrocyte population was completely

J. L. Mason; P. Ye; K. Suzuki; A. J. D’ercole; G. K. Matsushima

203

Proteolytic activation of latent transforming growth factor ~ from fibroblast-conditioned medium

  CiteSeer

Summary: Abstract. Transforming growth factor-13 (TGFI3) is produced by most cultured cells in an inactive form. Potential activation mechanisms of latent TGFI3 were studied using fibroblastic (NRK-49F and AKR-MCA) cell-conditioned medium as a model. Active TGFI3 was monitored by radioreceptor and soft agar assays as well as by antibody inhibition and immunoprecipitation. Little or no TGF[3 was detected in untreated conditioned medium. Treatment of the medium with extremes of pH (1.5 or 12) resulted in significant activation of TGFI3 as shown by radioreceptor assays, while mild acid treatment (pH 4.5) yielded only 20-30 % of the competition achieved by pH 1.5. In an effort to define more physiological means of TGFI3 activation, the effects of some proteases were tested.

Russette M. Lyons; Jorma Keski-oja; Harold L. Moses
1988-01-01

204

Lung overexpression of the vascular endothelial growth factor gene induces pulmonary edema

  CiteSeer

Summary: We hypothesized that the angiogenic mediator, vascular endothelial growth factor (VEGF), known to be expressed in the lung and to be capable of inducing local edema in skin, might evoke the development of lung edema if expressed in excess amounts. To test this hypothesis, we developed an in vivo model of VEGF overexpression in the lung on the basis of delivery to the respiratory epithelium of the VEGF165 complementary DNA by an E1 ? adenovirus vector (AdVEGF165). Administration of AdVEGF165 by the intratracheal route (10 9 plaque-forming units [pfu]) to C57Bl/6 mice showed increased expression of VEGF messenger RNA in lung tissue by Northern analysis. Overexpression of VEGF protein in the lung at Days 1 to 10 was confirmed by enzyme-linked immunosorbent assay. Intratracheal administration of AdVEGF165 resulted in a dose-dependent increase in lung wet/dry weight

Robert J. Kaner; John V. Ladetto; Ravi Singh; Norimasa Fukuda; Michael A. Matthay; Ronald G. Crystal
2000-01-01

205

Vascular Endothelial Growth Factor Receptor 2 Blockade Disrupts Postnatal Lung Development

  CiteSeer

Summary: Vascular endothelial growth factor (VEGF) is necessary for normal postnatal lung development and may underlie the structural lung damage that follows hyperoxic exposure. To determine the individual roles of VEGF receptors (VEGFR) 2 and 1 on postnatal lung growth, neonatal mice were treated with neutralizing antibodies to VEGFR-2 (DC101) or VEGFR-1 (MF1) in the perinatal period. At 1 wk of age, mice treated with DC101 on Days 2 and 4 of life had significantly larger mean alveolar diameters consistent with impaired alveolization. By 2 wk of age, however, perinatally treated DC101 mice had normal-appearing alveolar structure. Mice exposed to perinatal hyperoxia (O2) also had larger mean alveolar diameters at 1 wk of age, but unlike DC101-treated mice, their mitotic index was decreased at 1 wk of age and they had persistent alveolar enlargement beyond the first 2 wk of life. The O 2-treated lung also had an increase in caspase 3 at 1 wk of age and significantly greater expression of nitrotyrosine at 2 wk of age. Therefore, VEGFR-2 blockade in the perinatal period disrupts early alveolar development, but the effect is reversible with time, whereas hyperoxic lung injury is associated with ongoing lung structural impairment.

Sharon A. Mcgrath-morrow; Cecilia Cho; Chung Cho; Lijie Zhen; Daniel J. Hicklin; Rubin M. Tuder

206

Re: Loss of Imprinting of Insulin-Like Growth Factor-II

  Biology and Medicine Websites

Summary: Biologic Subtypes of Wilms Tumor In a recent issue of the Journal, Rav- enel et al. (1) claim that loss of Wilms tumors that have a different pathologic subtype, a later age of onset, and greater IGF2 expression nephrogenic rest (ILNR)-like tumors proposed by Beckwith et al. (2). However, Ravenel et al. (1) used only two

Broman, Karl W.

207

Angiotensin II potentiates vascular endothelial growth factor–induced angiogenic activity in

  CiteSeer

Summary: Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation Research can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at:

Atsushi Otani; Hitoshi Takagi; Kiyoshi Suzuma; Yoshihito Honda; Circ Res; Microcapillary Endothelial Cells; Atsushi Otani; Hitoshi Takagi; Kiyoshi Suzuma; Yoshihito Honda
1998-01-01

208

Ancient and continuing Darwinian selection on insulin-like growth factor II in placental fishes

  Environmental Sciences and Ecology Websites

Summary: (IGF2), and its antagonistic receptor, IGF2r, are oppositely imprinted in eutherian mammals and mar conflict, when antagonistic evolu- tionary processes such as a Red Queen race drive the rate to be the product of antagonistic evolution coincident with evolution of the placenta, but imprinted loci lack

Hrbek, Tomas - Department of Biology, Universidad de Puerto Rico

209

C H A P T E R E I G H T E E N Modeling of Growth Factor-Receptor

  Engineering Websites

Summary: C H A P T E R E I G H T E E N Modeling of Growth Factor-Receptor Systems: From Molecular systems 462 1.2. Computational models of the VEGF system 466 2. Molecular-Level Kinetics Models growth factor system involved in the in vivo regulation of blood vessel growth is called the vascular

Popel, Aleksander S.

210

CLINICAL STUDY Fibroblast growth factor (FGF)-23 in patients with primary hyperparathyroidism

  CiteSeer

Summary: Objective: We aimed to determine the serum level of fibroblast growth factor-23 (FGF-23) in patients with primary hyperparathyroidism (pHPT) to understand its physiological role in the disorder. Patients and methods: Ninety-eight patients with pHPT who underwent parathyroidectomy formed the study group. We also measured serum FGF-23 in 11 of these patients on postoperative day 6. Results: Serum FGF-23 levels was significantly higher in pHPT patients than in healthy controls (35.6^17.8 ng/l vs 28.9^11.2 ng/l (mean^S.D.); P, 0.001 (Pearson’s correlation coefficient)), but there was no significant difference in the serum FGF-23 level between pHPT patients with normal renal function (creatinine clearance (Ccr) of $70ml/min) and healthy controls. Serum FGF-23 correlated positively with serum calcium (P, 0.0001) and intact parathyroid hormone (PTH) (P, 0.01), and negatively with Ccr (P, 0.001), serum phosphate (P, 0.05), and serum 1,25-dihydroxyvitamin D (1,25(OH)2D) (P, 0.05). Multiple linear regression analysis of factors potentially determining serum FGF-23 levels in pHPT patients showed serum calcium (P, 0.01) and Ccr (P, 0.001) to be significant predictors. The serum levels of FGF-23 did not change after parathyroidectomy despite the normalization of serum calcium values. Multiple linear regression ana-

Hiroyuki Yamashita; Takeyoshi Yamashita; Masashi Miyamoto; Takashi Shigematsu; Junichiro James; Takashi Shimada; Yuji Yamazaki; Seiji Fukumoto; Masafumi Fukagaw; Shiro Noguchi

211

Chimeras of the Native Form or Achondroplasia Mutant (G375C) of Human Fibroblast Growth Factor Receptor 3 Induce

  CiteSeer

Summary: Mutations in the gene for human fibroblast growth factor receptor 3 (hFGFR3) cause a variety of skeletal dysplasias, including the most common genetic form of dwarfism, achondroplasia (ACH). Evidence indicates that these phenotypes are not due to simple haploinsufficiency of FGFR3 but are more likely related to a role in negatively regulating skeletal growth. The effects of one of these mutations on FGFR3 signaling were examined by constructing chimeric receptors composed of the extracellular domain of human platelet-derived growth factor receptor ? (hPDGFR?) and the transmembrane and intracellular domains of hFGFR3 or of an ACH (G375C) mutant. Following stable transfection in PC12 cells, which lack platelet-derived growth factor (PDGF) receptors, all clonal cell lines, with either type of chimera, showed strong neurite outgrowth in the presence of PDGF but not in its absence. Antiphosphotyrosine immunoblots showed ligand-dependent autophosphorylation, and both receptor types stimulated strong phosphorylation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase, an event associated with the differentiative response of these cells. In addition, ligand-dependent phosphorylation of phospholipase C ? and Shc was also observed. All of these responses were comparable to those observed from ligand activation, such as by nerve growth factor, of the native PC12 cells used to prepare the stable transfectants. The cells with the chimera bearing the ACH mutation were more rapidly responsive to ligand with less sustained MAPK activation, indicative of a preactivated

Ligand-dependent Differentiation; Pc Cells; Leslie M. Thompson; Simona Raffioni; John J. Wasmuth; Ralph A. Bradshaw
1997-01-01

212

T-Quark Mass and Hyperfinite II1 von Neumann factor

  Physics (arXiv)

Summary: A theoretical model based on the D4 Lie Algebra and Hermitian Symmetric Spaces D5 / D4xU(1) and E6 / D5xU(1) allows calculation of ratios of tree-level particle masses (quark masses being constituent masses): Me-neutrino = Mmu-neutrino = Mtau-neutrino = 0 Me = 0.5110 MeV (assumed); Md = Mu = 312.8 MeV; Mmu = 104.8 MeV; Ms = 625 MeV; Mc = 2.09 GeV; Mtau = 1.88 GeV; Mb = 5.63 GeV; Mt = 130 GeV; W+/- mass = 80.326 GeV; Z0 mass = 91.862 GeV; Higgs mass = 145.8 GeV; Higgs VEV = 252.5 GeV; and ratios of force strength constants: (Ggravity)(Mproton)2 = 5 x 10-39 (asssumed); EM fine structure constant = 1/137.03608; Gfermi = (Gweak)(Mproton)2 = 1.02 x 10-5; color force strength = 0.6286 (at 0.245 GeV). With Nonperturbative QCD etc taken into account the color force strength = 0.123 (at 91 GeV). Fermilab (1994) says that Mt = about 170 GeV but I say (1984) that Mt = about 130 GeV. The theoretical Lagrangian is based on the structure of the real Cl(1,7) Clifford algebra which, through 8-fold periodicity, may produce a real Hyperfinite II1 von Neumann Algebra factor.

Frank Smith Jr.
2004-02-12

213

Trade-offs between Stretch Factor and Load Balancing Ratio in Routing on Growth Restricted

  Computer Technologies and Information Sciences Websites

Summary: and growth rate k if the number of nodes in every ball with radius r is bounded by rk . The communication growth rate. In this paper we study the trade-off between two quality measures for routing in growth has density and growth rate k if for every r 1 and every node v in the graph, there are at most rk

Gao, Jie

214

2009 SSAT QUICK SHOT PRESENTATION An Analysis of Trends and Growth Factor Receptor Expression of GI Carcinoid Tumors

  CiteSeer

Summary: # 2009 The Society for Surgery of the Alimentary Tract Introduction The purpose of our study was twofold: (1) to determine the incidence, patient and tumor characteristics, and outcome of patients with gastrointestinal carcinoid tumors using the Surveillance, Epidemiology and End Results (SEER) database, and (2) to delineate the expression pattern of growth factor receptors (GFRs) in carcinoid tumors. Materials and methods The SEER database search provided information on patients diagnosed with carcinoid tumors from 1990 to 2002. Carcinoid tumor sections (n=46) were stained for the GFRs: epidermal growth factor receptor, insulin-like

Kanika A. Bowen; Scott R. Silva; Jessica N. Johnson; Hung Q. Doan; Lindsey N. Jackson; Pat Gulhati; Suimin Qiu; Taylor S. Riall; B. Mark Evers
2009-01-01

215

Damping of the baryon acoustic oscillations in the matter power spectrum as a probe of the growth factor

  Astrophysics (arXiv)

Summary: We investigate the damping of the baryon acoustic oscillations (BAO) signature in the matter power spectrum due to the quasi-nonlinear clustering of density perturbations. On the basis of the third order perturbation theory, we construct a fitting formula of the damping in an analytic way. This demonstrates that the damping is closely related with the growth factor and the amplitude of the matter power spectrum. Then, we investigate the feasibility of constraining the growth factor through a measurement of the damping of the BAO signature. An extension of our formula including higher order corrections of density perturbations is also discussed.

Hidenori Nomura; Kazuhiro Yamamoto; Takahiro Nishimichi
2008-10-20

216

A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative

  Computer Technologies and Information Sciences Websites

Summary: factor 2 gene expression at four alternative translation initiation codons Bonnal Sophie 1 , Schaeffer C, Initiator ; genetics ; DNA, Complementary ; genetics ; Fibroblast Growth Factor 2 ; genetics ; Gene ; Transfection INTRODUCTION The human FGF-2 gene belongs to a gene family of 23 fibroblast growth factors

Boyer, Edmond

217

Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: A morphological and immunohistochemical study

  University of Cambridge - Dspace

Summary: at least 10 weeks. Hence, they could provide an important source of nutrients, growth factors and cytokines for the feto-placental unit. The endometrium may therefore play a greater role in regulating placental growth and differentiation post...

Hempstock, Joanne; Cindrova-Davies, Tereza; Jauniaux, Eric; Burton, Graham
2004-07-20

218

The Journal of Immunology Inhibition of Epidermal Growth Factor Receptor Tyrosine

  CiteSeer

Summary: Rheumatoid arthritis (RA) is an autoimmune synovitis characterized by the formation of pannus and the destruction of cartilage and bone in the synovial joints. Although immune cells, which infiltrate the pannus and promote inflammation, play a prominent role in the pathogenesis of RA, other cell types also contribute. Proliferation of synovial fibroblasts, for example, underlies the formation of the pannus, while proliferation of endothelial cells results in neovascularization, which supports the growth of the pannus by supplying it with nutrients and oxygen. The synovial fibroblasts also promote inflammation in the synovium by producing cytokines and chemokines. Finally, osteoclasts cause the destruction of bone. In this study, we show that erlotinib, an inhibitor of the tyrosine kinase epidermal growth factor receptor (EGFR), reduces the severity of established collagen-induced arthritis, a mouse model of RA, and that it does so by targeting synovial fibroblasts, endothelial cells, and osteoclasts. Erlotinib-induced attenuation of autoimmune arthritis was associated with a reduction in number of osteoclasts and blood vessels, and erlotinib inhibited the formation of murine osteoclasts and the proliferation of human endothelial cells in vitro. Erlotinib also inhibited the proliferation and cytokine production of human synovial fibroblasts in vitro. Moreover, EGFR was highly expressed and activated in the synovium of mice with collagen-induced arthritis and patients with RA. Taken together, these findings suggest that EGFR plays a central role in the pathogenesis of RA and that EGFR inhibition may provide benefits in the treatment of RA. The Journal of Immunology, 2012, 188: 3513–3521. R

Kinase Ameliorates; Collagen-induced Arthritis; Christina D. Swanson; Elliot H. Akama-garren; Emily A. Stein; Jacob D. Petralia; Pedro J. Ruiz; Abdolhossein Edalati; Tamsin M. Lindstrom; William H. Robinson

219

Nucleation and growth in one dimension, part II: Application to DNA replication kinetics

  Condensed Matter (arXiv)

Summary: Inspired by recent experiments on DNA replication, we apply a one-dimensional nucleation-and-growth model to DNA-replication kinetics, focusing on how to extract the time-dependent nucleation rate I(t) and growth speed v from data. We discuss generic experimental problems, namely spatial inhomogeneity, measurement noise, and finite-size effects. After evaluating how each of these affects the measurements of I(t) and v, we give guidelines for the design of experiments. These ideas are then discussed in the context of the DNA-replication experiments.

Suckjoon Jun; John Bechhoefer
2004-08-12

220

Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors

  Biology and Medicine Websites

Summary: Myc and YY1 mediate activation of the Surf-1 promoter in response to serum growth factors Ellen G; accepted 26 April 2000 Abstract The human Surf-1 and Surf-2 genes are divergently transcribed and share transcription in the Surf-1 direction, but has no effect on transcription in the Surf-2 direction. Mutations

Gaston, Kevin

221

The Effects of Nerve Growth Factor on Spatial Recent Memory in Aged Rats Persist after Discontinuation of Treatment

  Biology and Medicine Websites

Summary: 21205 Nerve growth factor (NGF) infusion significantly reduces spatial recent memory deficits in aged examined. Four- and 22-month-old rats were tested preoper- atively, infused intraventricularly with recombinant human NGF or vehicle, and tested both during the 4 week infusion period and during the 4 weeks

Frick, Karyn M.

222

[125I]-Labeled monoclonal antibody L8A4 against epidermal growth factor receptor variant III (EGFRvIII)

  Biology and Medicine Websites

Summary: transmembrane epidermal growth factor receptors (EGFRs) are described elsewhere (1-3). The EGFRs are known epithelial tumors (2, 3). Overexpression of the EGFR in tumors has been attributed to cellular amplification). In addition, overexpression of the EGFR in tumors usually indicates a poor clinical prognosis for a cancer

Levin, Judith G.

223

The transforming growth factor-(TGF) family of proteins is a large group of secreted pleiotropic cytokines

  Chemistry Websites

Summary: The transforming growth factor- (TGF) family of proteins is a large group of secreted pleiotropic immune system TGF signalling has a non-redundant essential role, which includes limiting the elaboration the development of certain lymphocyte subsets and limiting T-cell-mediated autoimmunity4,5 . In the immune system

Cai, Long

224

Insulin-like Growth Factor 2 Is Required for Progression to Advanced Medulloblastoma in patched1 Heterozygous Mice

  Biotechnology Websites

Summary: . It was previously shown that the loss of function of insulin-like growth factor 2 (igf2) suppresses MB formation precursors (GNP; ref. 1). Loss of function of the PATCHED1 (PTCH, ptc1 in mice) tumor suppressor gene, which spontaneously form MB and rhabdomyosarcoma (RMS), a tumor derived from muscle (14, 15). These tumors exhibit

Quake, Stephen R.

225

An in vivo study on the effect of scaffold geometry and growth factor release on the healing of bone defects

  Materials Science Websites

Summary: -implantation, the defects were evaluated by CTscan and histology. Analysis revealed that the basic architecture, having (34.9 Ã?10.7). It also showed the highest histological analysis scores with a high amount of bone forma the growth factor-free basic scaffold at 6 weeks (BMD 206.8 Ã?15.7). Histological analysis also revealed new

Hasýrcý, Vasýf

226

Transforming Growth Factor (TGF ) Mediates Schwann Cell Death In Vitro and In Vivo: Examination of c-Jun Activation,

  Biology and Medicine Websites

Summary: Transforming Growth Factor (TGF ) Mediates Schwann Cell Death In Vitro and In Vivo: Examination to Schwann Cell Differentiation David B. Parkinson,1 Ziping Dong,4 Howard Bunting,1 Jonathan Whitfield,3 Neuroanatomie, Med. Einrichtungen der Ruhr-Universita¨ t, 44780 Bochum, Germany In some situations, cell death

Jessen, Kristjan R

227

Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon

  Biology and Medicine Websites

Summary: Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through, small interfering RNA- mediated hAhR ablation inhibits TCDD and omeprazole- dependent hIGFBP-1 induction molecules of 90-kDa heat shock protein and a single molecule of the co- chaperone hepatitis X

Perdew, Gary

228

Cyclic Adenosine 3',5'-Monophosphate-Elevating Agents Inhibit Transforming Growth Factor--Induced SMAD3/4-Dependent

  Physics Websites

Summary: activator inhibitor-1; PGE2, prostaglandin E2; PKA: protein kinase A; TGF-, transforming growth factor--Induced SMAD3/4-Dependent Transcription Via a Protein Kinase A-Dependent Mechanism Meinhard Schiller, Frank, plasminogen activator inhibitor 1, we show that membrane- permeable dibutyryl cAMP, and other intracellular c

Paris-Sud XI, Université de

229

1583Journal of Thoracic Oncology Volume7,Number10,October2012 Introduction: Erlotinib (Tarceva) is an epidermal growth factor

  Biology and Medicine Websites

Summary: ) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, which effectively tar- gets EGFR faster, even if make-up doses are attempted. Conclusions: For existing and new kinase inhibitors-molecule tyrosine kinase inhibitors (TKIs) in cancer therapy is that prolonged target inhibition is essential. Thus


230

Parallel Dimers and Anti-parallel Tetramers Formed by Epidermal Growth Factor Receptor Pathway Substrate Clone 15 (EPS15)*

  Biology and Medicine Websites

Summary: Substrate Clone 15 (EPS15)* (Received for publication, August 28, 1997, and in revised form, October 17 The recently discovered localization of epidermal growth factor receptor pathway substrate clone 15 (Eps15 protein complex, AP-2, strongly suggest that Eps15 has an important role in the pathway of clathrin

Kirchhausen, Tomas

231

Properly Oriented Heparin-Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth Factor,

  Chemistry Websites

Summary: Properly Oriented Heparin-Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic: Interaction of basic fibroblast growth factor (FGF-2) with heparin or heparan sulfate proteoglycans (HSPGs of activation of the FGF receptor by FGF-2 and heparin, we have used NMR, dynamic light scattering, and HSPG

Powers, Robert

232

Impact of body condition on plasma leptin and insulin-like growth factor-I concentrations in stallions and geldings

  Texas A&M University - TxSpace

Summary: The objective of this study was to more clearly define the relationship between body condition, plasma leptin and insulin-like growth factor-I (IGF-I) in stallions and geldings in moderate (5.0-5.5) versus fleshy (7.0-7.5) body condition. Data...

Chancellor, Tommy Neal
2009-05-15

233

Actin depolymerizing factor is essential for viability in plants, and its phosphoregulation is important for tip growth

  Biology and Medicine Websites

Summary: is important for tip growth Robert C. Augustine1 , Luis Vidali1 , Ken P. Kleinman2 and Magdalena Bezanilla1,* 1. * For correspondence (fax +1 413 545 3243; e-mail bezanilla@bio.umass.edu). Summary Actin depolymerizing factor (ADF

Bezanilla, Magdalena

234

Stem CellRelated "Self-Renewal" Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance

  Biology and Medicine Websites

Summary: Stem Cell­Related "Self-Renewal" Signature and High Epidermal Growth Factor Receptor Expression pathways, and, more recently, to the particular biologic behavior of tumor stem-like cells. Here, we aimed treated within clinical trials testing the addition of concomitant and adjuvant temozolomide

Domany, Eytan

235

In recent years, informatics studies have predicted several new ways in which the transforming growth factor b (TGFb)

  Biology and Medicine Websites

Summary: , phosphorylation and nucleo-cytoplasmic shuttling. We review these studies and provide a brief `how to' guide, such as the transforming growth factor b (TGFb) family, perform a multitude of tasks. To illustrate the versatility sexual differentiation (reviewed by Derynck and Miyazono, 2008a). In order to perform these myriad roles

Newfeld, Stuart J.

236

Facile growth factor immobilization platform based on engineered phage So Young Yoo, Anna Merzlyak and Seung-Wuk Lee*

  Materials Science Websites

Summary: and cell morphology. We report a strategy for immobilizing growth factors on genetically engineered phage matrices for tissue regeneration. We modified M13 phages to express biotin-like peptides (HPQ) and of numerous cell types. Designing biomimetic materials with precisely controlled structural organization

Lee, Seung-Wuk

237

Integrin v 3 mediates platelet-derived growth factor-BB-stimulated collagen gel contraction in cells expressing signaling

  Biology and Medicine Websites

Summary: of functional interactions with collagen was studied. We expressed either wild-type 2 1 ( 2 1A) or 2 1 with a Y the collagen-binding integrin, 2 1, and platelet-derived growth factor (PDGF) receptors in the context to collagen even after transfection with 1A. Cells expressing 2 1Amut contracted three-dimensional collagen

Mosher, Deane F.

238

Crystallisation in flow Part II: Modelling crystal growth kinetics controlled by boundary layer thickness

  Physics Websites

Summary: to a natural case of calcite growth rate in 2D section perpendicular to the axis. The reconstructed calcite, a multidisciplinary study was carried out (Sizaret et al., Part I, 2006) on a well-known pipe-formed calcite. The AMS measurement on the magnetite-bearing calcite shows a good coherence between the magnetic lineation

Paris-Sud XI, Université de

239

Dark Matter Halo Growth II: Diffuse Accretion and its Environmental Dependence

  CERN Preprints

Summary: Dark matter haloes in Lambda CDM simulations grow by mergers with other haloes as well as accretion of "diffuse" non-halo material. We quantify the mass growth rates via these two processes, dM_mer/dt and dM_dif/dt, and their dependence on halo environment using the ~500,000 haloes in the Millennium simulation. Adopting a local mass density parameter as a measure of halo environment, we find the two rates show strong but opposite environmental dependence, with mergers playing an increasingly important role for halo growths in overdense regions and diffuse accretion dominating growth in voids. This behaviour is independent of the mass cuts used to define haloes vs non-haloes. For galaxy-scale haloes, these two opposite correlations largely cancel out, but a weak environmental dependence remains that results in a slightly lower mean total growth rate, and hence an earlier mean formation redshift, for haloes in denser regions. The mean formation redshift of the ~5000 cluster-mass haloes, on the other hand, appea...

Fakhouri, Onsi
2009-01-01

240

PHYSICAL REVIEW B 83, 035424 (2011) Role of codeposited impurities during growth. II. Dependence of morphology

  Materials Science Websites

Summary: ,1,4, and T. L. Einstein1,§ 1 Department of Physics, University of Maryland, College Park, Maryland, Tunisia 4 Scientific Attach´e, French Embassy in the United States, Consulate General of France, Houston of a small quantity (2%) of impurities with Cu during growth (step-flow mode, = 40 ML) significantly depends

Einstein, Theodore L.

241

The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells

  CiteSeer

Summary: Abstract. Depending on the target cells and culture conditions, scatter factor/hepatocyte growth factor (SF/HGF) mediates several distinct activities, i.e., cell motility, proliferation, invasiveness, tubular morphogenesis, angiogenesis, or cytotoxicity. A small isoform of SF/HGF encoded by a natural splice variant, which consists of the NH2-terminal hairpin structure and the first two kringle domains but not the protease homology region, induces cell motility but not mitogenesis. Two types of SF/HGF receptors have recently been discovered in epithelial cells, the high affinity c-Met receptor tyrosine kinase, and low affinity/high capacity binding sites, which are probably located on heparan sulfate proteoglycans. In the present study, we have addressed the question whether the various biological activities of SF/HGF are transduced into cells by a single type of receptor. We have here examined MDCK epithelial cells transfected with a hybrid cDNA encoding the ligand binding domain of the nerve growth factor (NGF) receptor and the membrane-spanning and tyrosine kinase domains of the Met receptor. We demonstrate that all biological effects of SF/HGF upon epithelial cells such as the induction of cell motility, proliferation, invasiveness, and tubular morphogenesis can now be triggered by the addition of NGE Thus, it is likely that all known biological signals of SF/HGF are transduced through the receptor tyrosine kinase encoded by the c-Met protooncogene. S CATTER factor/hepatocyte growth factor (SF/HGF) ~ has several distinct effects on cells in culture: (a) it is a strong mitogen for primary hepatocytes as well as other cell lines (Nakamura et al., 1987; Gohda et al., 1988; Zarnegar and Michalopoulos, 1989; Rubin et al., 1991); (b) it was independently identified as a motility and invasioninducing factor for epithelial and endothelial cells (Stoker et

K. Michael Weidner; Martin Sachs; Walter Birchmeier
1993-01-01

242

Down regulation of Epidermal Growth Factor receptors: direct demonstration of receptor degradation in human fibroblasts

  CiteSeer

Summary: ABSTRACT The metabolism of the receptor for epidermal growth factor (EGF) has been measured by labeling the receptor in vivo with radioactive amino acid precursors and then determining, by immunoprecipitation with specific anti-EGF receptor antisera, the rate of degradation of the receptor when the cells are placed in a nonradioactive medium. In human fibroblasts the rate of EGF receptor degradation (t1i2 = 10.1 h) was faster than the rate of degradation of total cell protein. When EGF was added to the nonradioactive medium, the half-life of prelabeled receptor was decreased to 1.2 h in human fibroblasts. These data demonstrate by direct analysis of receptor protein that during "down regulation " the EGF receptor is rapidly degraded. Enhanced receptor degradation was observed 5-10 min after the addition of EGF. The EGF-induced degradation of the receptor was blocked by methylamine, chloroquine, iodoacetate, or incubation at 25°C. We have also shown that EGF-induced down regulation in human fibroblasts results in a decrease in the total amount of EGF receptor protein present. The amount of EGF receptor protein has been quantitated by radiolabeling cellular protein and immunoprecipitation of the receptor. The EGF receptor constitutes ^-0.0035 % of the

Christa M Stoscheck; Graham Carpenter
1984-01-01

243

Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation

  CiteSeer

Summary: Hepatocyte growth factor (HGF), the ligand for the Met receptor tyrosine kinase, is a potent modulator of epithelial–mesenchymal transition and dispersal of epithelial cells, processes that play crucial roles in tumor development, invasion, and metastasis. Little is known about the Met-dependent proximal signals that regulate these events. We show that HGF stimulation of epithelial cells leads to activation of the Rho GTPases, Cdc42 and Rac, concomitant with the formation of filopodia and lamellipodia. Notably, HGF-dependent activation of Rac but not Cdc42 is dependent on phosphatidylinositol 3-kinase. Moreover, HGF-induced lamellipodia formation and cell spreading require phosphatidylinositol 3-kinase and are inhibited by dominant negative Cdc42 or Rac. HGF induces activation of the Cdc42/Rac-regulated p21-activated kinase (PAK) and c-Jun N-terminal kinase, and translocation of Rac, PAK, and Rho-dependent Rho-kinase to membrane ruffles. Use of dominant negative and activated mutants reveals an essential role for PAK but not Rho-kinase in HGF-induced epithelial cell spreading, whereas Rho-kinase activity is required for the formation of focal adhesions and stress fibers in response to HGF. We conclude that PAK and Rho-kinase play opposing roles in epithelial–mesenchymal transition induced by HGF, and provide new insight regarding the role of Cdc42 in these events.

Isabelle Royal; Nathalie Lamarche-vane; Louie Lamorte; Morag Park; Joan Brugge
1999-01-01

244

RAPID COMMUNICATIONS Phylogenetic Analysis of Platelet-derived Growth by Radio-receptor Assay Factor

  CiteSeer

Summary: ABSlRACt Competition between 12Sl-labeled platelet-derived growth factor (PDGF) and unlabeled PDGF forms the basis of a specific "radio-receptor assay " for quantifying PDGF in clotted blood serum. Human clotted blood serum contains 15 ng/ml of PDGF by radio-receptor assay; this corresponds to a PDGF content of ~7.5 x 10-5 pg per circulating platelet, a figure which is corroborated by purification data. Clotted blood sera from mammals, lower vertebrates and marine invertebrates were screened for homologues of human PDGF by radio-receptor assay. All tested specimens from phylum Chordata contain a mitogenic agent that competes with human PDGF for receptor binding. Sera from tunicates down on the chordate line of evolution and sera from all tested animals on the arthropod line of development were negative. The phylogenetic distribution of PDGF homologue does not correlate with platelet distribution since platelets and their precursor cell--the bone marrow megacaryocyteu are unique to the mammalian hematopoietic system. One anatomical feature appearing coordinately with PDGF on the vertebrate line of development is a pressurized circulatory system. The coincidental appearance of these features may lend support to the hypothesis that PDGF plays a role in maintenance and repair of the vascular lining in vivo.

Jai Pal Singh; Margery A. Chaikin; Charles D. Stiles

245

Epidermal growth factor receptor status as predictor of early recurrence of and death from breast cancer

  CiteSeer

Summary: The histological breakdown of a consecutive series of 264 surgically resected malignant lesions of the breast was studied. Oestrogen and epidermal growth factor receptor status was quantified and presented along with size and lymph node status of the non-ductal lesions. Those non-ductal tumours containing EGF receptors have all recurred within two years of resection. Twenty-one percent of the lobular carcinomas contained EGF receptors compared to 34 % of ductal carcinomas. EGF receptor status appeared to be associated with an increased risk of early recurrence and death whatever the histological sub-type of the breast cancer. Many prognostic variables have been described for use in the study of breast cancer. Patient variables (such as age at menarche or parity) and clinical findings (such as palpable lymph nodes) give useful information. Study of the resected specimen allows assessment of further variables. Size of the lesion is most accurately measured by the pathologist as is the involvement of lymph nodes with tumour. Various histological scoring systems

J. R. C. Sainsbury; S. Nicholson; B. Angus; J. R. Farndon; A. J. Malcolm; A. L. Harris
1987-01-01

246

Growth of galactic bulges by mergers. II. Low-density satellites

  Astrophysics (arXiv)

Summary: Satellite accretion events have been invoked for mimicking the internal secular evolutionary processes of bulge growth. However, N-body simulations of satellite accretions have paid little attention to the evolution of bulge photometric parameters, to the processes driving this evolution, and to the consistency of this evolution with observations. We want to investigate whether satellite accretions indeed drive the growth of bulges, and whether they are consistent with global scaling relations of bulges and discs. We perform N-body models of the accretion of satellites onto disc galaxies. A Tully-Fisher (M \\propto V_{rot}^ {alpha_TF}) scaling between primary and satellite ensures that density ratios, critical to the outcome of the accretion, are realistic. We carry out a full structural, kinematic and dynamical analysis of the evolution of the bulge mass, bulge central concentration, and bulge-to-disc scaling relations. The remnants of the accretion have bulge-disc structure. Both the bulge-to-disc ratio (B/D) and the Sersic index (n) of the remnant bulge increase as a result of the accretion, with moderate final bulge Sersic indices: n = 1.0 to 1.9. Bulge growth occurs no matter the fate of the secondary, which fully disrupts for alpha_TF=3 and partially survives to the remnant center for alpha_TF = 3.5 or 4. Global structural parameters evolve following trends similar to observations. We show that the dominant mechanism for bulge growth is the inward flow of material from the disc to the bulge region during the satellite decay. The models confirm that the growth of the bulge out of disc material, a central ingredient of secular evolution models, may be triggered externally through satellite accretion.

M. C. Eliche-Moral; M. Balcells; J. A. L. Aguerri; A. C. Gonzalez-Garcia
2006-06-30

247

ON THE GROWTH OF SUPERHARMONIC FUNCTIONS NEAR AN ISOLATED SINGULARITY. II

  Mathematics Websites

Summary: Mathematics Department Texas A&M University College Station, TX 77843 stalia@math.tamu.edu 1. Introduction In this paper we continue our study began in [10] of the growth near the origin of C 2 positive solutions u(x) of af(u) # -#u # f(u) in# (1.1) where# # IR n is a punctured neighborhood of the origin, a # [0, 1

Taliaferro, Steven D.

248

Electrostatic Barrier Against Dust Growth in Protoplanetary Disks. II. Measuring the Size of the "Frozen" Zone

  CERN Preprints

Summary: Coagulation of submicron-sized dust grains is the initial step of dust evolution in protoplanetary disks. This process can be significantly slowed down by the negative charging of dust aggregates in the weakly ionized disks. We apply the growth criteria obtained in Paper I to finding out a location where the charging stalls dust growth at the fractal growth stage, to which we will refer as the "frozen zone." We find that the frozen zone likely exists and covers a wide region of a disk, typically from a few AU to 100 AU from the central star. The maximum mass of the "frozen" fractal aggregates is approximately 10^-7 g at 1 AU and as small as a few monomer masses at 100 AU. The disk mass and the monomer size do not significantly affect the size of the frozen zone within a realistic range of these parameters. Strong turbulence can significantly reduce the size of the frozen zone, but such turbulence will cause the fragmentation of macroscopic aggregates made after the fractal stage. We consider the vertical mixi...

Okuzumi, Satoshi; Takeuchi, Taku; Sakagami, Masa-aki
2010-01-01

249

The Populus Class III HD ZIP Transcription Factor POPCORONA Affects Cell Differentiation during Secondary Growth of Woody Stems

  CiteSeer

Summary: The developmental mechanisms regulating cell differentiation and patterning during the secondary growth of woody tissues are poorly understood. Class III HD ZIP transcription factors are evolutionarily ancient and play fundamental roles in various aspects of plant development. Here we investigate the role of a Class III HD ZIP transcription factor, POPCORONA, during secondary growth of woody stems. Transgenic Populus (poplar) trees expressing either a miRNA-resistant POPCORONA or a synthetic miRNA targeting POPCORONA were used to infer function of POPCORONA during secondary growth. Whole plant, histological, and gene expression changes were compared for transgenic and wild-type control plants. Synthetic miRNA knock down of POPCORONA results in abnormal lignification in cells of the pith, while overexpression of a miRNA-resistant POPCORONA results in delayed lignification of xylem and phloem fibers during secondary growth. POPCORONA misexpression also results in coordinated changes in expression of genes within a previously described transcriptional network regulating cell differentiation and cell wall biosynthesis, and hormone-related genes associated with fiber differentiation. POPCORONA illustrates another function of Class III HD ZIPs: regulating cell differentiation during secondary growth.

Juan Du ¤a; Eriko Miura; Marcel Robischon ¤b; Ciera Martinez; Andrew Groover
2010-01-01

250

ii

  CiteSeer

Summary: iii Gray Wolves (Canis lupus) are a focal species for rare Temperate Rainforests located on the central coast of British Columbia, Canada. Characteristics of coastal wolf habitat are unknown. Wolf presence/absence data and spatial, physical and biological attributes of the coastal landscape were compiled in GIS and analysed with logistic regression. Akaike’s Information Criterion was used to select the best model describing wolf habitat. Island area and shape positively influenced wolf presence while distance to mainland, inter-island distance, and logged area negatively predicted wolf presence. Sub-island analysis showed positive effects on wolf occurrence from deer density and range of forest age, and a negative effect from mean forest age. Models had high classification accuracy evaluated with jackknife validation and Relative Operating Characteristic (ROC) curves. Identification of factors comprising coastal wolf habitat enhance understanding of the coastal ecosystem and are useful for conservation management and planning. iv

Patricia L. Swan; Patricia L. Swan
2005-01-01

251

Large time asymptotics of growth models on space-like paths II: PNG and parallel TASEP

  Mathematical Physics (arXiv)

Summary: We consider the polynuclear growth (PNG) model in 1+1 dimension with flat initial condition and no extra constraints. The joint distributions of surface height at finitely many points at a fixed time moment are given as marginals of a signed determinantal point process. The long time scaling limit of the surface height is shown to coincide with the Airy_1 process. This result holds more generally for the observation points located along any space-like path in the space-time plane. We also obtain the corresponding results for the discrete time TASEP (totally asymmetric simple exclusion process) with parallel update.

Alexei Borodin; Patrik L. Ferrari; Tomohiro Sasamoto
2007-07-28

252

Scatter Factor/Hepatocyte Growth Factor and its receptor, the c-met tyrosine kinase, can mediate a signal exchange between mesenchyme and epithelia during mouse development

  CiteSeer

Summary: Abstract. Scatter factor/hepatocyte growth factor (SF/HGF) has potent motogenic, mitogenic, and morphogenetic activities on epithelial cells in vitro. The cell surface receptor for this factor was recently identified: it is the product of the c-met protooncogene, a receptor-type tyrosine kinase. We report here the novel and distinct expression patterns of SF/HGF and its receptor during mouse development, which was determined by a combination of in situ hybridization and RNase protection experiments. Predominantly, we detect transcripts of c-met in epithelial cells of various developing organs, whereas the ligand is expressed in distinct mesenchymal cells in close vicinity. In addition, transient SF/HGF and c-met expression is found at certain sites of muscle formation; transient expres-

Eva Sonnenberg; Dirk Meyer; K. Michael Weidner; Carmen Birchmeier
1993-01-01

253

Sequences of B-Chain/Domain 1-10/1-9 of Insulin and Insulin-like Growth Factor 1 Determine Their Different Folding Behavior

  Biology and Medicine Websites

Summary: Sequences of B-Chain/Domain 1-10/1-9 of Insulin and Insulin-like Growth Factor 1 DetermineVed February 9, 2004; ReVised Manuscript ReceiVed May 14, 2004 ABSTRACT: Although insulin and insulin-like growth factor-1 (IGF-1) belong to one family, insulin folds into one thermodynamically stable structure

Tian, Weidong

254

The Different Folding Behavior of Insulin and Insulin-like Growth Factor 1 Is Mainly Controlled by Their B-Chain/Domain

  Biology and Medicine Websites

Summary: The Different Folding Behavior of Insulin and Insulin-like Growth Factor 1 Is Mainly ControlledVed October 19, 2001 ABSTRACT: Although insulin and insulin-like growth factor 1 (IGF-1) share homologous highly homologous sequences encode different folding behavior: insulin folds into one unique stable

Tian, Weidong

255

Src-mediated Inter-receptor Cross-talk between the Na /K -ATPase and the Epidermal Growth Factor Receptor Relays the Signal from

  Biology and Medicine Websites

Summary: activates tyro- sine phosphorylation of the epidermal growth factor receptor (EGFR), Src, and p42/44 mitogen and the EGFR in the ouabain-invoked pathways that lead to the activa- tion of MAPKs. Exposure of A7r5 and LLC-induced but not epidermal growth factor- induced Src binding to the EGFR and the subsequent EGFR tyrosine phosphorylation

Brand, Paul H.

256

Population statistics of beamed sources. II: Evaluation of Doppler factor estimates

  CERN Preprints

Summary: In a companion paper we presented a statistical model for the blazar population, consisting of distributions for the unbeamed radio luminosity function and the Lorentz factor distribution of each of the BL Lac and Flat Spectrum Radio Quasar (FSRQ) classes. Our model has been optimized so that it reproduces the MOJAVE distributions of apparent speeds and redshifts when the appropriate flux limit is applied and a uniform distribution of jet viewing angles is assumed for the population. Here we use this model to predict the Doppler factor distribution for various flux-limited samples for which Doppler factors have been estimated in a variety of ways (equipartition, variability + equipartition, inverse Compton dominance) on a blazar-by-blazar basis. By comparing the simulated and data-estimated Doppler factor distributions in each case, we evaluate the different methods of estimating blazar Doppler factors. We find that the variability Doppler factors assuming equipartition are the ones in the best agreement with...

Liodakis, I
2014-01-01

257

Effects of growth hormone and insulinlike growth factor I on salinity tolerance and gill Na + ,K + -ATPase in Atlantic salmon (Salmo salar): Interaction with cortisol. Gen

  CiteSeer

Summary: The potential roles of growth hormone (GH) and insulin-like growth factor I (IGF-I) in seawater (SW) acclimation of juvenile Atlantic salmon (Salmo salar) were examined. Compared to controls, fish in 12 ppt seawater given one or three injections (2–6 days) of GH (ovine, 0.2 µg ·g ?1) or IGF-I (recombinant bovine, 0.05–0.2 µg ·g ?1) had significantly greater salinity tolerance as judged by lower plasma sodium, osmolality, and muscle moisture content following transfer to 34 ppt. Single injections of GH and IGF-I in fish in fresh water failed to improve salinity tolerance following transfer to 25 ppt SW. Treatment of fish in 12 ppt with GH or IGF-I for 2–6 days did not increase gill Na +,K +-ATPase activity, but treatment with GH prevented decreases in gill Na +, K +-ATPase activity that occurred in controls following

Stephen D. Mccormick
1996-01-01

258

Growth of galactic bulges by mergers. II. Low-density satellites

  CERN Preprints

Summary: Satellite accretion events have been invoked for mimicking the internal secular evolutionary processes of bulge growth. However, N-body simulations of satellite accretions have paid little attention to the evolution of bulge photometric parameters, to the processes driving this evolution, and to the consistency of this evolution with observations. We want to investigate whether satellite accretions indeed drive the growth of bulges, and whether they are consistent with global scaling relations of bulges and discs. We perform N-body models of the accretion of satellites onto disc galaxies. A Tully-Fisher (M \\propto V_{rot}^ {alpha_TF}) scaling between primary and satellite ensures that density ratios, critical to the outcome of the accretion, are realistic. We carry out a full structural, kinematic and dynamical analysis of the evolution of the bulge mass, bulge central concentration, and bulge-to-disc scaling relations. The remnants of the accretion have bulge-disc structure. Both the bulge-to-disc ratio (B/D...

Eliche-Moral, M C; López-Aguerri, J A; Gonzalez-Garcia, A C
2006-01-01

259

Targeted Overexpression of Insulin-Like Growth Factor I to Osteoblasts of Transgenic Mice: Increased

  Biology and Medicine Websites

Summary: in the osteocyte la- cunea occupancy, suggesting that IGF-I may extend the osteocyte life span. We conclude, and osteocytes and deposited into bone matrix. In the rodent, IGF-II is believed to function primarily to control

Pike, J. Wesley

260

On The Structure Of The Chan-Paton Factors For D-Branes In Type II Orientifolds

  HEP - Theory (arXiv)

Summary: We determine the structure of the Chan-Paton factors of the open strings ending on space filling D-branes in Type II orientifolds. Through the analysis, we obtain a rule concerning possible distribution of O-plane types. The result is applied to classify the topology of D-branes in terms of Fredholm operators and K-theory, deriving a proposal made earlier and extending it to more general cases. It is also applied to compactifications with N=1 supersymmetry in four-dimensions. We adapt and develop the language of category in this context, and use it to describe some decay channels.

Dongfeng Gao; Kentaro Hori
2010-04-22

261

Relativistic Thermal Bremsstrahlung Gaunt Factor for the Intracluster Plasma. II. Heavy Elements

  Astrophysics (arXiv)

Summary: We calculate the relativistic thermal bremsstrahlung Gaunt factor for the high-temperature plasma which exists in clusters of galaxies. We calculate the Gaunt factor by employing the Bethe-Heitler cross section corrected by the Elwert factor. The calculations in this paper are made for the fully ionized plasma for the following cases: Z = 10 (Ne), 12 (Mg), 14 (Si), 16 (S), 26 (Fe). We also calculate the Gaunt factor by using the Coulomb-distorted wave functions for nonrelativistic electrons following the method of Karzas and Latter. By comparing the Gaunt factors calculated by these two different methods, we carefully assess the accuracy of the calculation. We present the numerical results in the form of tables.

Satoshi Nozawa; Naoki Itoh; Yasuharu Kohyama
1998-04-21

262

Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells

  CiteSeer

Summary: Abstract. Nerve growth factor induces neurite process formation in pheochromacytoma (PC12) cells and causes the parallel increase in levels of the microtubule-associated proteins, tau and MAP1, as well as increases in tubulin levels. Mechanisms to insure balanced accumulation of microtubule proteins and make their levels highly responsive to nerve growth factor were investigated. The effects on tau, MAP1, and tubulin are due to changes in protein synthesis rates, which for tau and tubulin we could show are due in part to changes in the mRNA levels. Whereas tubulin shows feedback regulation to modulate synthesis up or down, tau protein synthesis is not affected in a straightforward way by microtubule polymerization and depolymerization. The degradation of tau,

David Drubin; Sumire Kobayashi; Doug Kellogg; Marc Kirschner
1988-01-01

263

Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,30-diindolylmethane

  CiteSeer

Summary: 3,30-Diindolylmethane (DIM), an indole derivative pro-duced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM’s antiangiogenic activity. We found that DIM can inhibit vascular endothelial growth factor (VEGF)-induced cell proliferation and DNA synthesis in human umbilical vas-cular endothelial cells (HUVECs). Consistent with this inhibition, VEGF-induced extracellular signal-regulated kinase (ERK1/2) phosphorylation was greatly reduced. However, VEGF receptor phosphorylation induced by VEGF was not affected by DIM, indicating that DIM does not exert a direct and specific effect on the tyrosine kinase activity of this receptor. Further studies showed that DIM had a similar inhibitory effect on ERK1/2 phosphoryla-tion induced by a variety of growth factors. Furthermore, Ras–GTP content, which dramatically increased after HUVECs were challenged by either individual growth fac-tors or serum, was reduced by 80 % with 25 mM DIM treatment, which in turn resulted in the reduced activities of Raf and MEK, culminating in the drop of ERK1/2 activation. Overexpression of constitutively active GTPase mutant, Ras G12V, in HUVECs reversed the inhibitory effect of DIM on ERK1/2 activation. In a rodent Matrigel plug model, the presence of DIM strongly reduced VEGF-induced neovascularization, indicating that DIM is active in vivo. These data provide evidence that DIM inhibits Ras signaling induced by VEGF and other growth factors, which interferes with its downstream biological effects necessary for angiogenesis.

Leonard F. Bjeldanes

264

High resolution spectroscopy for Cepheids distance determination. II. A period- projection factor relation

  CERN Preprints

Summary: The projection factor is a key quantity for the interferometric Baade-Wesselink (hereafter IBW) and surface-brightness (hereafter SB) methods of determining the distance of Cepheids. Indeed, it allows a consistent combination of angular and linear diameters of the star. We aim to determine consistent projection factors that include the dynamical structure of the Cepheids' atmosphere. Methods. Hydrodynamical models of delta Cep and l Car have been used to validate a spectroscopic method of determining the projection factor. This method, based on the amplitude of the radial velocity curve, is applied to eight stars observed with the HARPS spectrometer. The projection factor is divided into three sub-concepts : (1) a geometrical effect, (2) the velocity gradient within the atmosphere, and (3) the relative motion of the "optical" pulsating photosphere compared to the corresponding mass elements (hereafter fo-g). Both, (1) and (3) are deduced from geometrical and hydrodynamical models, respectively, while (2) is d...

Nardetto, N; Mathias, Ph; Fokin, A; Gillet, D
2008-01-01

265

II_{\\infty} Factors and M-theory in Asymptotically Flat Space-Time

  HEP - Theory (arXiv)

Summary: I discuss a formulation of M-theory at null infinity, which is based on general principles of holographic space-time, and is manifestly covariant. The construction utilizes a certain Type II Von Neumann algebra, which provides a kinematic framework, alternative to Fock Space, for describing the scattering states of eleven dimensional asymptotically flat M-theory. The construction provides a greatly clarified statement of the connection between SUSY and holography. I make preliminary remarks about dynamical equations for the S-matrix, and compactifications.

T. Banks
2006-07-03

266

Clumping factors of HII, HeII and HeIII

  CERN Preprints

Summary: Estimating the intergalactic medium ionization level of a region needs proper treatment of the reionization process for a large representative volume of the universe. The clumping factor, a parameter which accounts for the effect of recombinations in unresolved, small-scale structures, aids in achieving the required accuracy for the reionization history even in simulations with low spatial resolution. In this paper, we study for the first time the redshift evolution of clumping factors of different ionized species of H and He in a small but very high resolution simulation of the reionization process. We investigate the dependence of the value and redshift evolution of clumping factors on their definition, the ionization level of the gas, the grid resolution, box size and mean dimensionless density of the simulations.

Jeeson-Daniel, Akila; Graziani, Luca
2014-01-01

267

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3

  Materials Science Websites

Summary: in cartilage matrix included excessive proteolysis of aggrecan core protein and type II collagen, as measured of metalloproteinase MMP13, type X collagen, cellular hypertrophy and loss of proteo- glycan at the articular surface and proteoglycan (aggrecan) matrix that is secreted and maintained by relatively few chondrocytes in the adult

Buschmann, Michael

268

High resolution spectroscopy for Cepheids distance determination. II. A period- projection factor relation

  Astrophysics (arXiv)

Summary: The projection factor is a key quantity for the interferometric Baade-Wesselink (hereafter IBW) and surface-brightness (hereafter SB) methods of determining the distance of Cepheids. Indeed, it allows a consistent combination of angular and linear diameters of the star. We aim to determine consistent projection factors that include the dynamical structure of the Cepheids' atmosphere. Methods. Hydrodynamical models of delta Cep and l Car have been used to validate a spectroscopic method of determining the projection factor. This method, based on the amplitude of the radial velocity curve, is applied to eight stars observed with the HARPS spectrometer. The projection factor is divided into three sub-concepts : (1) a geometrical effect, (2) the velocity gradient within the atmosphere, and (3) the relative motion of the "optical" pulsating photosphere compared to the corresponding mass elements (hereafter fo-g). Both, (1) and (3) are deduced from geometrical and hydrodynamical models, respectively, while (2) is derived directly from observations. The Fe I 4896.439 A line is found to be the best one to use in the context of IBW and SB methods. A coherent and consistent period-projection factor relation (hereafter Pp relation) is derived for this specific spectral line: p = [0.064 +- 0.020] log P + [1.376 +- 0.023]. This procedure is then extended to derive dynamic projection factors for any spectral line of any Cepheid. This Pp relation is an important tool for removing bias in the calibration of the period-luminosity relation of Cepheids. Moreover, it reveals a new physical quantity fo-g to investigate in the near future.

N. Nardetto; D. Mourard; Ph. Mathias; A. Fokin; D. Gillet
2008-04-08

269

Role of IGF-II/M6P receptor in the regulation of brain function.

  Open Access Theses and Dissertations

Summary: ??Insulin-like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor is a single trans-membrane glycoprotein that is widely but selectively distributed throughout the central nervous system (CNS). IGF-II/M6P receptor is… (more)

Amritraj, Asha
2010-01-01

270

The Role of Vascular Endothelial Growth Factor at the Blood-Brain Barrier in Diabetes.

  Open Access Theses and Dissertations

Summary: ??Diabetes is a risk factor for stroke and vascular dementia. Clinical studies using gadolinium-magnetic resonance imaging techniques have shown diabetic patients exhibit a permeability increase… (more)

Marcelo, Aileen J.
2012-01-01

271

Factors controlling common smelt abundance and rainbow trout growth in the Rotorua Lakes, New Zealand.

  Open Access Theses and Dissertations

Summary: ??Recreational fisheries are of considerable ecological, economic and cultural importance worldwide, and understanding the factors that influence them is an important goal of fishery managers.… (more)

Blair, Jennifer Marie
2012-01-01

272

Molecular line intensities as measures of cloud masses - II. Conversion factors for specific galaxy types

  Astrophysics (arXiv)

Summary: We present theoretically-established values of the CO-to-H2 and C-to-H2 conversion factors that may be used to estimate the gas masses of external galaxies. We consider four distinct galaxy types, represented by M51, NGC 6946, M82 and SMC N27. The physical parameters that best represent the conditions within the molecular clouds in each of the galaxy types are estimated using a chi^2 analysis of several observed atomic fine structure and CO rotational lines. This analysis is explored over a wide range of density, radiation field, extinction, and other relevant parameters. Using these estimated physical conditions in methods that we have previously established, CO-to-H2 conversion factors are then computed for CO transitions up to J=9-8. For the conventional CO(1-0) transition, the computed conversion factor varies significantly below and above the canonical value for the Milky Way in the four galaxy types considered. Since atomic carbon emission is now frequently used as a probe of external galaxies, we also present, for the first time, the C-to-H2 conversion factor for this emission in the four galaxy types considered.

T. A. Bell; S. Viti; D. A. Williams
2007-04-19

273

Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and

  Biology and Medicine Websites

Summary: acid-binding protein (FABP4/aP2) (9). GDF3 overexpression in mice by adenovirus gene transfer resulted/differentiation factor 3 (GDF3) is highly expressed in adipose tissue, and previous overexpression experiments in mice have suggested that it may act as an adipogenic factor under conditions of high lipid load. GDF3 has

Ibáñez, Carlos

274

Further fractionation studies on unidentified growth factors in distillers dried solubles

  Texas A&M University - TxSpace

Summary: in either corn ox soy- bean oil meal, The factor was similar to the one found in casein by Carrick et al. , ('4'u) ~ Hill et al. , ('44) pxe- sented. data on a deficiency of an unidentified factor in practical chick xat'iona whicn was suppliea...

Rozacky, Eugene Emil
1955-01-01

275

High Temperature Requirement Factor A1 (HTRA1) Gene Regulates Angiogenesis through Transforming Growth

  Biology and Medicine Websites

Summary: High Temperature Requirement Factor A1 (HTRA1) Gene Regulates Angiogenesis through Transforming, China Background: Genetic variants of high temperature requirement factor A1 (HTRA1) associate with AMD with AMD. HTRA1 knock-out mice display reduced blood vessel in retina and up-regulation of GDF6. Conclusion


276

Regulation of RNA polymerase II transcription by sequence-specific DNA binding factors

  CiteSeer

Summary: unfortunate consequence of this complexity that the critical role of the sequence-specific factors is sometimes overlooked. In an earlier time, our view of transcription was not so complicated. I will therefore go back in time to the early 1980s and describe some of our ideas and knowledge (or what I remember of what we thought we knew) regarding sequence-specific factors. I will then briskly travel forward in time through the present and into the future. This account reflects some selected thoughts and impressions, and is not meant to be comprehensive. To capture the flavor of this earlier era in transcriptional regulation, I have cited “vintage ” papers and reviews. I hope that this perspective will be of some interest and utility to a broad range of scientists, particularly those

James T. Kadonaga
2004-01-01

277

ESCRT factors restrict mycobacterial growth Jennifer A. Philips*, Maura C. Porto*, Hui Wang*, Eric J. Rubin

  Biology and Medicine Websites

Summary: growth. Mycobacterium phagosome tuberculosis ubiquitin One-third of the human population is infected with M. tuberculosis, and each year it causes 2­3 million deaths. The success of M. tuberculosis acidify or recruit late endosomal markers, such as Rab7, or mature lyso- somal hydrolases. M. tuberculosis

Higgins, Darren

278

Acorn Size As A Factor in Early Seedling Growth of Blue Oaks1

  Environmental Sciences and Ecology Websites

Summary: .) acorns of different size classes (weights) and from different trees which produced predominantly small size also affected other variables in a significant manner. Parent tree influence was significant for some variables but not for height growth. In diverse tree species researchers have reported that seed

Standiford, Richard B.

279

Purified Plasma Membranes Inhibit Polypeptide Growth Factor-induced DNA Synthesis

  Biology and Medicine Websites

Summary: Angeles, California 90024 ABSTRACT Plasma membranes derived from NR-6 cells, a varient line of Swiss mouse is a variant cell line obtained from clone 42 3T3 cells that has no detectable EGF-binding activity (12). SerumT3 Cells The growth in culture of untransformed fibroblasts such as murine 3T3 cells, is dependent

Vale, Ronald D.

280

Initial B564 Question: What Regulates Population Growth? Abiotic Factors or Biotic Interactions

  Environmental Sciences and Ecology Websites

Summary: structured by stabilizing, density-dependent interactions, or are communities random assemblages formed thru immigration (and speciation)? #12;2 1. List Community Properties/Metrics Diversity, Stability, ... 2. Contrast Productivity Total Growth Biomass = Stored Energy Stability General: Resistance to Perturbation 1. Mathematical

Caraco, Thomas

281

What Do Aging, Exercise, Swallowing Problems, and Nerve Growth Factors Have in Common?

  Fission and Nuclear Technologies Websites

Summary: are proteins found in the body that help with nerve function. They are important for nerve growthB and BDNF was measured with a staining protocol that uses fluorescent antibodies to these proteins (shown below). The amount of fluorescence (red for BDNF and green for TrkB) indicates the amount of protein

Wisconsin at Madison, University of

282

Soft processes at the LHC, II: Soft-hard factorization breaking and gap survival

  CERN Preprints

Summary: We calculate the probability that the rapidity gaps in diffractive processes survive both eikonal and enhanced rescattering. We present arguments that enhanced rescattering, which violates soft-hard factorization, is not very strong. Accounting for NLO effects, there is no reason to expect that the black disc regime is reached at the LHC. We discuss the predictions for the survival of the rapidity gaps for exclusive Higgs production at the LHC.

Ryskin, M G; Khoze, V A
2008-01-01

283

Form factors in finite volume II:disconnected terms and finite temperature correlators

  HEP - Lattice (arXiv)

Summary: Continuing the investigation started in a previous work, we consider form factors of integrable quantum field theories in finite volume, extending our investigation to matrix elements with disconnected pieces. Numerical verification of our results is provided by truncated conformal space approach. Such matrix elements are important in computing finite temperature correlation functions, and we give a new method for generating a low temperature expansion, which we test for the one-point function up to third order.

B. Pozsgay; G. Takacs
2007-06-25

284

Soft processes at the LHC, II: Soft-hard factorization breaking and gap survival

  HEP - Phenomenology (arXiv)

Summary: We calculate the probability that the rapidity gaps in diffractive processes survive both eikonal and enhanced rescattering. We present arguments that enhanced rescattering, which violates soft-hard factorization, is not very strong. Accounting for NLO effects, there is no reason to expect that the black disc regime is reached at the LHC. We discuss the predictions for the survival of the rapidity gaps for exclusive Higgs production at the LHC.

M. G. Ryskin; A. D. Martin; V. A. Khoze
2008-12-12

285

Epithelial-Specific and Stage-Specific Functions of Insulin-Like Growth Factor-I during Postnatal Mammary Development

  CiteSeer

Summary: Postnatal development of the mammary gland requires inter-actions between the epithelial and stromal compartments, which regulate actions of hormones and growth factors. IGF-I is expressed inbothepithelial and stromal compartmentsdur-ing postnatal development of the mammary gland. However, little is known about how local expression of IGF-I in epithe-lium or stroma regulates mammary growth and differentia-tion during puberty and pregnancy-induced alveolar devel-opment. The goal of this study was to investigate the mechanisms of IGF-I actions in the postnatal mammary gland and test the hypothesis that IGF-I expressed in stromal and epithelial compartments has distinct functions. We estab-lished mouse lines with inactivation of the igf1 gene in mam-mary epithelium by crossing igf1/loxP mice with mouse lines expressing Cre recombinase under the control of either the

Aimee V. Loladze; Malinda A. Stull; Anne M. Rowzee; Jean Demarco; James H. Lantry Iii; Clifford J. Rosen; Derek Leroith; Kay-uwe Wagner; Lothar Hennighausen; Teresa L. Wood

286

C/EBPb contributes to hepatocyte growth factor-induced replication of rodent hepatocytes

  Biology and Medicine Websites

Summary: critical for this process are not clear. C/EBPb and C/EBPa are liver-enriched transcription factors, and the effect upon hepatocyte replication was determined. Results: HGF had no effect in rat liver upon C/EBPa

Ponder, Katherine P.

287

Two Distinct Modes of Signaling by Vascular Endothelial Growth Factor C Guide Blood and Lymphatic Vessel Patterning in Zebrafish: A Dissertation.

  Open Access Theses and Dissertations

Summary: ??Vascular Endothelial Growth Factor Receptor-3 (VEGFR3/Flt4) and its ligand Vegfc are necessary for development of both blood and lymphatic vasculature in vertebrates. In zebrafish, Vegfc/Flt4… (more)

Villefranc, Jacques A.
2011-01-01

288

Effect of Intravitreous Anti–Vascular Endothelial Growth Factor Therapy on Choroidal Thickness in Neovascular Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography

  MIT - DSpace

Summary: A critical method of monitoring patients with neovascular age-related macular degeneration (AMD) being treated with anti–vascular endothelial growth factor (anti-VEGF) is optical coherence tomography (OCT), which uses ...

Branchini, Lauren

289

In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds

  MIT - DSpace

Summary: The inability of articular cartilage to repair itself after acute injury has been implicated in the development of osteoarthritis. The objective of this work was to develop methods for delivering growth factors to cartilage ...

Miller, Rachel E. (Rachel Elizabeth)
2010-01-01

290

Quantitative analysis of 2D and 3D models for epidermal growth factor receptor-dependent cell migration in the context of the extracellular microenvironment

  MIT - DSpace

Summary: Major therapeutic efforts have been devoted to targeting the epidermal growth factor receptor (EGFR), which is aberrantly expressed in many cancers and is correlated with tumor progression and invasiveness. In the current ...

Kim, Hyung-Do, Ph. D. Massachusetts Institute of Technology
2009-01-01

291

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

  MIT - DSpace

Summary: Epidermal growth factor receptor (EGFR)-mediated signaling helps regulate bone development and healing through its effects on osteogenic cells. Here, we show how EGFR activity and osteogenic differentiation responses in ...

Platt, Manu O.

292

Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor

  CiteSeer

Summary: Abstract. The time course of molecular events that accompany degeneration and death after nerve growth factor (NGF) deprivation and neuroprotection by NGF and other agents was examined in cultures of NGFdependent neonatal rat sympathetic neurons and compared to death by apoptosis. Within 12 h after onset of NGF deprivation, glucose uptake, protein synthesis, and RNA synthesis fell precipitously followed by a moderate decrease of mitochondrial function. The molecular mechanisms underlying the NGF deprivation-induced decrease of protein synthesis and neuronal death were compared and found to be different, demonstrating that this decrease of protein synthesis is insufficient to cause death subsequently. After these early changes and during the onset of neuronal atrophy,

Thomas L. Deckwerth; Eugene M. Johnson
1993-01-01

293

Receptor-mediated endocytosis of epidermal growth factor by hepatocyte in the perfused rat liver: ligand and receptor dynamics

  CiteSeer

Summary: Abstract. Substantial amounts of epidermal growth factor (EGF) are cleared from the circulation by hepatocytes via receptor-mediated endocytosis and subsequently degraded within lysosomes. We have used a combined biochemical and morphological approach to examine the fate of the receptor after exposure to EGF. Polyclonal antibodies were prepared against the purified receptor and their specificity established by immunoprecipitation and immunoblotting techniques. The EGF receptor was then localized by immunofluorescence and immunoperoxidase techniques and quantified on immunoblots. In untreated livers, EGF receptor was restricted to the sinusoidal and lateral surfaces of hepatocytes. 2-4 min after exposure of cells to EGF, the receptor was found in small vesicles

William A. Dunn; Timothy P. Connolly; Ann L. Hubbard
1984-01-01

294

Modeling CO Emission: II. The Physical Characteristics that Determine the X factor in Galactic Molecular Clouds

  CERN Preprints

Summary: We investigate how the X factor, the ratio of H_2 column density (NH2) to velocity-integrated CO intensity (W), is determined by the physical properties of gas in model molecular clouds (MCs). We perform radiative transfer calculations on chemical-MHD models to compute X. Using integrated NH2 and W reproduces the limited range in X found in observations, resulting in a mean value X=2\\times10^20 s/cm^2/K^1/km^1 from the Galactic MC model. However, in limited velocity intervals, X can take on a much larger range due to CO line saturation. Thus, X strongly depends on both the range in gas velocities and volume densities. The temperature (T) variations within individual MCs do not strongly affect X, as dense gas contributes most to setting X. For fixed velocity and density structure, gas with higher T has higher W, yielding X ~ T^-1/2 for T~20-100 K. We demonstrate that the linewidth-size scaling relation does not influence the X factor - only the range in velocities is important. Clouds with larger linewidths, r...

Shetty, Rahul; Dullemond, Cornelis P; Ostriker, Eve C; Harris, Andrew I; Klessen, Ralf S
2011-01-01

295

Up- regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis

  CiteSeer

Summary: Capillary hemangioblastoma is the most frequent manifestation of the autosomal dominantly inherited von Hippel-Lindau (VHL) disease but also presents as a nonfamilial, sporadic vascular tumor. Hemangioblasto mas are characterized by a dense network of capillaries in association with cysts. To investigate the mechanisms underlying neovascularization and cyst formation, we analyzed eight VHL disease-associated and five spo radic hemangioblastomas. Histologically, both tumor types showed a sim ilar phenotype. The capillaries expressed the endothelial cell markers von Willebrand factor and CD31 antigen. We investigated the expression of vascular endothelial growth factor (VEGF), an endothelial cell-specific mitogen which is also known to induce vascular permeability in vivo, and its high affinity tyrosine kinase receptors.//'- / and r\\l>K. Northern blot and

S. Wizigmann-voos; G. Breier; W. Risau; Et Al; Cancer Res; Contact The Aacr Publications; S. Wizigmann-voos; G. Breier; W. Risau; K. H. Plate
1993-01-01

296

Fourier Theory on the Complex Plane II: Weak Convergence, Classification and Factorization of Singularities

  Mathematical Physics (arXiv)

Summary: The convergence of DP Fourier series which are neither strongly convergent nor strongly divergent is discussed in terms of the Taylor series of the corresponding inner analytic functions. These are the cases in which the maximum disk of convergence of the Taylor series of the inner analytic function is the open unit disk. An essentially complete classification, in terms of the singularity structure of the corresponding inner analytic functions, of the modes of convergence of a large class of DP Fourier series, is established. Given a weakly convergent Fourier series of a DP real function, it is shown how to generate from it other expressions involving trigonometric series, that converge to that same function, but with much better convergence characteristics. This is done by a procedure of factoring out the singularities of the corresponding inner analytic function, and works even for divergent Fourier series. This can be interpreted as a resummation technique, which is firmly anchored by the underlying analytic structure.

Jorge L. deLyra
2014-09-15

297

Relativistic Thermal Bremsstrahlung Gaunt Factor for the Intracluster Plasma. II. Analytic Fitting Formulae

  Astrophysics (arXiv)

Summary: We present accurate analytic fitting formulae which summarize the results of the recent calculation by Nozawa, Itoh and Kohyama on the relativistic thermal bremsstrahlung Gaunt factor for the intracluster plasma. The fitting is carried out for Z = 1 to 28, 6.0 < log T < 8.5, -4.0 < log (omega/kT) < 1.0, where Z is the charge number of the ion, T is the temperature, and omega is the angular frequency of the emitted photon. The present analytic fitting formulae will be useful for the analysis of the X-ray emission which comes from the intracluster plasma as well as the other X-ray sources.

Naoki Itoh; Tsuyoshi Sakamoto; Shugo Kusano; Satoshi Nozawa; Yasuharu Kohyama
2007-07-31

298

Original article Effects of gas atmosphere, platelet-derived growth factor

  Computer Technologies and Information Sciences Websites

Summary: factor on cell numbers of rabbit embryos cultured in a protein-free medium JR Giles RH Foote Department October 1996) Summary ― While culture conditions for embryos have improved, development in vitro atmospheres were evaluated for their effect on rabbit embryo development. Adding PDGF, mLIF or h

Boyer, Edmond

299

VEGF121 and VEGF165 Regulate Blood Vessel Diameter Through Vascular Endothelial Growth Factor Receptor

  Biology and Medicine Websites

Summary: provide critical factors that promote sprouting, lumen formation, and vessel stability. Using this assay capillary sprouting. Moreover, specific inhibition of VEGFR-2 signaling results in a dramatic reduction of EC sprouting in response to VEGF, indicating the critical importance of this receptor. The increase

Hughes, Christopher C. W.

300

Differentiating effects of somatomedin-C/insulin-like growth factor I and insulin on Leydig

  Computer Technologies and Information Sciences Websites

Summary: -C/IGF-I increased hCG receptor number and the cAMP and testosterone responses to this hormone. The enhanced secretion and spermatogenesis, are mainly under the control of pituitary hormones. While it is clear indicate that in addition to this endocrine regulation, other hormones and factors, coming from the blood

Boyer, Edmond

301

Direct Numerical Simulation of Reionization II: Recombinations, Clumping Factors, and the Photon Budget for Reionization

  CERN Preprints

Summary: In this first of several application papers, we investigate the mechanics of reionization from stellar sources in high-z galaxies, the utility of various clumping factors on estimating the recombination time in the IGM, and the photon budget required to achieve reionization. We test the accuracy of the static and time-dependent models of Madau et al. as predictors of reionization completion/maintenance. We simulate a WMAP7 LCDM cosmological model in a 20 Mpc comoving cube with 800^3 uniform fluid cells and dark matter particles. By tuning our star formation to approximately match the observed star formation rate density and luminosity function, we created a fully coupled radiation-hydro realization of H reionization which begins to ionize at z~10 and completes at z~5.8. We find that roughly 2 ionizing photons per H atom are required to convert the neutral IGM to a highly ionized state, which supports the "photon starved" scenario discussed by Bolton & Haehnelt. The events during reionization that lead to ...

So, Geoffrey C; Reynolds, Daniel R; Harkness, Robert P
2013-01-01

302

JL: Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall. Am Respir Crit Care Med 2006

  CiteSeer

Summary: Background: Small airway remodeling (SAR) is an important cause of airflow obstruction in cigarette smokers with chronic obstructive pulmonary disease, but the pathogenesis of SAR is not understood. Objective: To determine whether smoke causes production of profibrotic growth factors in the airway wall. Methods: We exposed C57Bl/6 mice to cigarette smoke for up to 6 mo and examined growth factor/procollagen gene expression in laser-capture microdissected small airways by real-time reverse transcription–polymerase chain reaction. Results: With a single smoke exposure, increases in procollagen, connective tissue growth factor (CTGF), transforming growth factor (TGF)- ? 1, platelet-derived growth factor (PDGF)-A and-B expression were seen 2 h after the start of smoking and declined to baseline by 24 h. With repeated exposures and at killing of animals 24 h after the last exposure, increases in procollagen, CTGF, PDGF-B, and (minimally) PDGF-A expression persisted through 1 wk, 1 mo, and 6 mo. TGF- ? 1 gene expression declined over time; however, increased immunochemical staining for phopho-Smad 2 was present at all time points, indicating continuing TGF- ? downstream signaling. Morphometric analysis showed that the small airways in smoke-exposed mice had more collagen at 6 mo. Conclusions: These findings suggest that smoke can induce growth factor and procollagen production in small airways in a time frame that initially is too short for a significant inflammatory response and that profibrotic growth factor and procollagen gene expression become self-sustaining with repeated smoke exposures. These results imply that the pathogenesis of and possible treatment approaches to emphysema and small airway remodeling might be quite different.

Andrew Churg; Hsin Tai; Tonya Coulthard; Rona Wang; Joanne L. Wright

303

Mechanistic Studies of Palladium Thin Film Growth from Palladium(II) -Diketonates. 1. Spectroscopic Studies of the

  Chemistry Websites

Summary: Studies of the Reactions of Bis(hexafluoroacetylacetonato)palladium(II) on Copper Surfaces Wenbin Lin Abstract: The reactions of bis(hexafluoroacetylacetonato)palladium(II), Pd(hfac)2, on copper have been studied. Whereas multilayers of Pd(hfac)2 desorb molecularly from copper surfaces between 200 and 270 K

Girolami, Gregory S.

304

Common polymorphism in H19associated with birthweight and cord blood IGF-II levels in humans

  University of Cambridge - Dspace

Summary: is an important common determinant of maternal-uterine restraint, as first-born infants are more likely to be restrained in utero and show compensatory postnatal catch-up growth, compared to subsequent-born infants [5]. Heritable or genetic factors may also... of the genes known to be imprinted and paternally or maternally expressed influence fetal growth [8]. An imprinted region on chromosome 11p15.5 in humans regulates the major fetal growth factor "insulin-like growth factor-II" (IGF-II). The IGF2 gene...

Petry, Clive J; Ong, Ken K; Barratt, Bryan J; Wingate, Diane; Cordell, Heather J; Ring, Susan M; Pembrey, Marcus E; ALSPAC Study Team; Reik, Wolf; Todd, John A; Dunger, David B
2005-05-10

305

Specific Uptake of Tumor Necrosis Factor- ? Is Involved in Growth Control of Trypanosoma brucei

  CiteSeer

Summary: Abstract. Trypanosoma brucei is lysed by tumor necrosis factor- ? (TNF-?) in a dose-dependent way, involving specific binding of the cytokine to a trypanosomal glycoprotein present in the flagellar pocket of the parasite. TNF-?–gold particles are endocytosed via coated pits and vesicles and are directed towards lysosome-like digestive organelles. The specific uptake of the cytokine by the parasite results in a developmentally regulated loss of osmoregulatory capacity. TNF- ? specific lysis is prevented when lysis assays are performed at a temperature ?26?C, despite uptake of the cytokine. Inhibition of lysis is also observed when a lysosomotropic agent is added during the first 2 h of incubation. Both monomorphic and pleomorphic trypanosomes are lysed but only when isolated during the peak of parasitaemia.

Stefan Magez; Maurice Geuskens; Alain Beschin; Herwig Del Favero; Hendrik Verschueren; Ralf Lucas; Etienne Pays; Patrick De Baetselier

306

Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells

  CiteSeer

Summary: Basic fibroblast growth factor (bFGF) exerts a mitogenic effect on cortical neuroblasts, whereas neurotrophin 3 (NT3) promotes differentiation in these cells. Here we provide evidence that both the mitogenic effect of bFGF and the differentiationpromoting effect of NT3 are linked with modifications of cell cycle kinetics in mouse cortical precursor cells. We adapted an in vitro assay, which makes it possible to evaluate (1) the speed of progression of the cortical precursors through the cell cycle, (2) the duration of individual phases of the cell cycle, (3) the proportion of proliferative versus differentiative divisions, and (4) the influence on neuroglial differentiation. Contrary to what has been claimed previously, bFGF promotes proliferation via a change in cell cycle kinetics by simultaneously decreasing G 1 duration and increasing the proportion of proliferative divisions. In contrast, NT3 lengthens G 1 and promotes differentiative

Agnès Lukaszewicz; Pierre Savatier; Véronique Cortay; Henry Kennedy; Colette Dehay

307

Growth factors induce nuclear translocation of MAP kinases (1>42 mapk and p44 mapk) but not of

  CiteSeer

Summary: Abstract. Mitogen-activated protein kinases (p42 '~'k and p44 "~k) are serine/threonine kinases that are activated rapidly in cells stimulated with various extracellular signals. This activation is mediated via MAP kinase kinase (p45-~-t), a dual specificity kinase which phosphorylates two key regulatory threonine and tyrosine residues of MAP kinases. We reported previously that the persistent phase of MAP kinase activation is essential for mitogenically stimulated cells to pass the "restriction point " of the cell cycle. Here, using specific polyclonal antibodies and transfection of epitopetagged recombinant MAP kinases we demonstrate that these signaling protein kinases undergo distinct spatiotemporal localization in growth factor-stimulated cells. In G0-arrested hamster fibroblasts the activator

Claude Sardet; Anne Brunet; Jacques Pouyssgur
1993-01-01

308

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis

  CiteSeer

Summary: Abstract. We have found that the spontaneous migration of bovine aortic endothelial cells from the edge of a denuded area in a confluent monolayer is dependent upon the release of endogenous basic fibroblast growth factor (bFGF). Cell movement is blocked by purified polyclonal rabbit IgG to bFGF as well as affinity purified anti-bFGF IgG and anti-bFGF F(ab')2 fragments. The inhibitory effect of the immunoglobulins is dependent upon antibody concentration, is reversible, is overcome by the addition of recombinant bFGF, and is removed by affinity chromatography of the antiserum through a column of bFGF-Sepharose. Cell movement is also reversibly inhibited by the addition of protamine sulfate and suramin; two agents reported to block bFGF binding to its receptor. The addition of

Yasufumi Sato; Daniel B. Rifkin
1988-01-01

309

COMPUTER SIMULATION OF A HOLLOW-FIBER BIOREACTOR: HEPARAN REGULATED GROWTH FACTORS-RECEPTORS BINDING AND DISSOCIATION ANALYSIS

  CiteSeer

Summary: This thesis demonstrates the use of numerical simulation in predicting the behavior of proteins in a flow environment. A novel convection-diffusion-reaction computational model is first introduced to simulate fibroblast growth factor (FGF-2) binding to its receptor (FGFR) on cell sur-faces and regulated by heparan sulfate proteoglycan (HSPG) under flow in a biore-actor. The model includes three parts: (1) the flow of medium using incompressible Navier-Stokes equations; (2) the mass transport of FGF-2 using convection-diffusion equations; and (3) the cell surface binding using chemical kinetics. The model con-sists of a set of coupled nonlinear partial differential equations (PDEs) for flow and mass transport, and a set of coupled nonlinear ordinary differential equations (ODEs) for binding kinetics. To handle pulsatile flow, several assumptions are made includ-

Changjiang Zhang; Changjiang Zhang; Changjiang Zhang
2011-01-01

310

JCB Article Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice

  CiteSeer

Summary: uchenne muscular dystrophy is an X-linked degenerative disorder of muscle caused by the absence of the protein dystrophin. A major consequence of muscular dystrophy is that the normal regenerative capacity of skeletal muscle cannot compensate for increased susceptibility to damage, leading to repetitive cycles of degeneration– regeneration and ultimately resulting in the replacement of muscle fibers with fibrotic tissue. Because insulin-like growth factor I (IGF-I) has been shown to enhance muscle regeneration and protein synthetic pathways, we asked whether high levels of muscle-specific expression of IGF-I in mdx muscle could preserve muscle function in the diseased state. In transgenic mdx mice expressing mIgf-I (mdx:mIgf ?/ ? D), we showed that muscle mass increased by at least 40 % leading to similar increases in force generation in

Elisabeth R. Barton; Linda Morris; Antonio Musaro; Nadia Rosenthal; H. Lee Sweeney

311

Research Article Macrophage Migration Inhibitory Factor in Fetoplacental Tissues from Preeclamptic Pregnancies with or without Fetal Growth Restriction

  CiteSeer

Summary: Copyright © 2012 Simona Cardaropoli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The proinflammatory cytokine MIF (macrophage migration inhibitory factor) is involved in physiological and pathological processes in pregnancy. MIF maternal serum levels are increased in preeclampsia (PE). We hypothesize that pregnancy tissues are the source of MIF overexpression in PE. MIF protein was studied in maternal sera, placental tissues, fetal membranes, and umbilical cord of 8 control and 20 PE pregnancies: 10 with normal fetal growth (PE-AGA) and 10 with fetal growth restriction (PE-FGR). MIF levels were significantly higher in PE-AGA membranes than in controls and PE-FGR. In PE-FGR, MIF cord concentrations were higher than in PE-AGA while MIF placental levels were lower than in controls. MIF maternal serum levels were higher in PE, compared to controls, and the difference was mainly due to PE-FGR samples. These data support MIF involvement in PE pathogenesis and suggest that different pregnancy tissues contribute to MIF production in PE with and without fetoplacental compromise. 1.

Simona Cardaropoli; Luana Paulesu; Roberta Romagnoli; Francesca Ietta; Daniela Marzioni; Mario Castellucci; Ro Rolfo; Elena Vasario; Ettore Piccoli; Tullia Todros

312

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

  CiteSeer

Summary: Abstract. Integrins mediate cell adhesion, migration, and a variety of signal transduction events. These integrin actions can overlap or even synergize with those of growth factors. We examined for mechanisms of collaboration or synergy between integrins and growth factors involving MAP kinases, which regulate many cellular functions. In cooperation with integrins, the growth factors EGF, PDGF-BB, and basic FGF each produced a marked, transient activation of the ERK (extracellular signal-regulated kinase) class of MAP kinase, but only if the integrins were both aggregated and occupied by ligand. Transmembrane accumulation of total tyrosine-phosphorylated proteins, as well as nonsynergistic MAP kinase activation, could be induced by simple integrin aggregation, whereas enhanced transient accumulation

Shingo Miyamoto; Hidemi Teramoto; J. Silvio Gutkind; Kenneth M. Yamada
1996-01-01

313

Variation and condition factor and growth in young-of-year fishes in floodplain and riverine habitats of the Cosumnes River, CA. Hydrobiologia 527: 77–84

  CiteSeer

Summary: Condition factors and growth rates of postlarval (young-of-year) fishes in a Central California river were compared in order to determine the relative importance of floodplain and riverine habitats for rearing. Sampling took place between April and June of 2001 and 2002 in the lower Cosumnes River and its floodplain. Sacramento splittail showed higher condition and length increment in floodplain habitats than in riverine habitats. Sacramento suckers showed differences in condition between sites, but suckers from the floodplain had lower weight increments than those from the river. The weight increment in Sacramento splittail was not significantly different between habitats. In addition, two alien species, common carp and golden shiner, had similar condition factors and growth rates. This study shows the usefulness of condition factor and growth rate in evaluating the importance of different habitats for early life history stages of fishes.

F. Ribeiro; P. K. Crain; P. B. Moyle
2004-01-01

314

Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension

  CiteSeer

Summary: Vascular endothelial growth factor (VEGF) is a potent mitogenic and permeability factor targeting predominantly endothelial cells. At least two tyrosine kinase receptors, Flk-1 and Flt-1, mediate its action and are mostly expressed by endothelial cells. VEGF and VEGF receptor expression are upregulated by hypoxia in vivo and the role of VEGF in hypoxia-induced angiogenesis has been extensively studied in a variety of disease entities. Although VEGF and its receptors are abundantly expressed in the lung, their role in hypoxic pulmonary hypertension and the accompanying vascular remodeling are incompletely understood. We report in this in vivo study that hypoxia increases mRNA levels for both VEGF and Flk-1 in the rat lung. The kinetics of the hypoxic response differ between receptor and ligand: Flk-1 mRNA showed a biphasic response to hypoxia with a significant, but transient, rise in mRNA levels observed after 9–15 h of hypoxic exposure and the highest levels noted after 3 wk. In contrast, VEGF mRNA levels did not show a significant increase with acute hypoxia, but increased progressively after 1–3 wk of hypoxia. By in situ hybridization, VEGF mRNA was localized predominantly in alveolar epithelial cells with increased signal in the lungs of hypoxic animals compared with controls. Immunohistochemical staining with anti-VEGF antibodies localized VEGF peptide throughout the lung parenchyma and was increased in hypoxic compared with normoxic animals. Furthermore, hypoxic animals had significantly higher circulating VEGF

Helen Christou; Atsushi Yoshida; Victoria Arthur; Toshisuke Morita; Stella Kourembanas
1998-01-01

315

Mechanistic Studies of Palladium Thin Film Growth from Palladium(II) -Diketonates. 2. Kinetic Analysis of the

  Chemistry Websites

Summary: a clean copper surface is dosed with Pd(hfac)2 and heated in ultrahigh vacuum; the transmetalation Analysis of the Transmetalation Reaction of Bis(hexafluoroacetylacetonato)palladium(II) on Copper Surfaces Abstract: The reaction pathways and kinetics for the selective deposition of palladium on copper from

Girolami, Gregory S.

316

Growth, Atomic Structure, and Type-II Band Alignment of GaSb/GaAs Quantum Dots and Rings

  Mathematics Websites

Summary: defined at negative VS two electric field effects: ! tip-induced band bending, perpendicular to cleavage appearance of GaSb/GaAs layer depending on bias polarity: ! broadly smoothened at positive VS ! sharply surface ! additional band bending parallel to surface, due to type-II band alignment 10 nm V = -1.8 VS

Nabben, Reinhard

317

Factors

  CiteSeer

Summary: To determine frequency of methicillin-resistant Staphylococcus aureus infections caused by strains typically associated with community-acquired infections (USA300) among persons with healthcare-related risk factors (HRFs), we evaluated surveillance data. Of patients with HRFs, 18%–28 % had a “community-associated” strain, primarily USA300; of patients without HRFs, 26% had a “healthcare-associated ” strain, typically USA100. In the United States, initial reports of methicillin-resistant Staphylococcus aureus (MRSA) infections among injection drug users in Detroit in 1981 were followed by reports of MRSA associated with the deaths of 4 children in Minnesota and North Dakota in 1997 (1). For the next few years, public health personnel in several states investigated outbreaks of MRSA infections of skin and soft tissue among diverse populations who typically had little or no previous contact with the healthcare system, such as Native Americans (2), sports teams (3), prison inmates (4),

Healthcare Risk; R. Monina Klevens; Melissa A. Morrison; Scott K. Fridkin; Arthur Reingold; Susan Petit; Ken Gershman; Susan Ray; Lee H. Harrison; Ruth Lynfield; Ghinwa Dumyati; John M. Townes; Allen S. Craig; Gregory Fosheim; Linda K. Mcdougal; Fred C. Tenover For

318

Biochem. J. (2005) 390, 125136 (Printed in Great Britain) doi:10.1042/BJ20041955 125 Hepatocyte growth factor is a preferred in vitro substrate for human

  Biology and Medicine Websites

Summary: identified. Cell culture studies with baby hamster kidney cells overexpressing human hepsin showed a calcium-dependenBiochem. J. (2005) 390, 125­136 (Printed in Great Britain) doi:10.1042/BJ20041955 125 Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease

Craik, Charles S.

319

Using DNA Microarray to Identify Sp1 as a Transcriptional Regulatory Element of Insulin-like Growth Factor-1 in Cardiac Muscle Cells

  Computer Technologies and Information Sciences Websites

Summary: -like Growth Factor-1 in Cardiac Muscle Cells Tao Li1 , Yung-Hsiang Chen1,2 , Tsun-Jui Liu1,2 , Jia Jia1 in myocardial remodeling. We have studied cardiac muscle gene expression with DNA microarray and employed) stimulation in cardiac muscle cells. The analysis showed that the Sp1 binding site is a likely target of IGF-1

Kibler, Dennis F.

320

Protein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling Induced 3T3-L1

  Biology and Medicine Websites

Summary: with inhibitors of phos- phatidylinositol 3-kinase, LY294002 or wortmannin, leads to the complete blockadeProtein Kinase B/AKT 1 Plays a Pivotal Role in Insulin-like Growth Factor-1 Receptor Signaling the phosphatidylinositol 3-kinase-protein ki- nase B/Akt signal cascade. In 3T3-L1 preadipocytes, pro- tein kinase B/Akt 1

Tian, Weidong

321

X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Michael Blaber,*, Jerry DiSalvo,| and Kenneth A. Thomas|

  Biology and Medicine Websites

Summary: a potential heparin binding site. The hydrogen bond with the N2 moiety of Asn 18 appears to be the mostFGF) and similar but not identical to interactions observed for bovine aFGF with heparin analogs. Of the added spectrum growth factor yet characterized. As with the other characterized FGFs, aFGF binds to heparin

Blaber, Michael

322

Clinical Study Enhanced Vascular Endothelial Growth Factor Gene Expression in Ischaemic Skin of Critical Limb Ischaemia Patients

  CiteSeer

Summary: Copyright © 2012 Silvia Bleda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. To perform a quantitative analysis of the vascular endothelial growth factor (VEGF) gene transcription in the skin of ischemic legs and provide information for VEGF in the pathogenesis in critical limb ischemia (CLI). Methods. Skin biopsies were obtained from 40 patients with CLI. Control samples came from 44 patients with chronic venous disease. VEGF gene expression was analysed using quantitative polymerase chain reaction. Results. Patients with CLI had higher skin VEGF expression than control group (RQ: 1.3 ± 0.1 versus 1, P = 0.04). Conclusions. We found an association between ischemic skin and an elevated VEGF expression in legs from patients with CLI. These data support that the mechanism for VEGF upregulation in hypoxia conditions is intact and acts appropriately in the ischaemic limbs from patients with CLI. 1.

Silvia Bleda; Joaquín De Haro; Francisco Acin; César Varela; Leticia Esparza

323

THE DIETARY GLYCEMIC INDEX AND ITS IMPLICATIONS IN CANCER RISK, INSULIN-LIKE GROWTH FACTORS AND OXIDATIVE STRESS

  CiteSeer

Summary: This thesis is an investigation of the role of the dietary glycemic index (GI) in endometrial and ovarian cancer risk and two potential mechanisms, related to insulin-like growth factors (IGF) and oxidative stress. The dietary GI is a measure of the foods ’ potential for blood glucose rises and the higher the GI the higher the blood glucose and insulin responses. In studies 1 and 2, the average daily GI of the diet was assessed in subjects with newly diagnosed endometrial cancer, those with ovarian cancer and in healthy controls. These case-control studies found positive associations between dietary GI and risk of endometrial and ovarian cancer (Odds Ratios, 2.1 and 1.7 respectively, for highest versus lowest GI quintile). These and other emerging studies indicate a possible link between high GI diets and cancer risk suggesting a potential role of glucose and insulin in carcinogenesis and a possible protective effect of low GI diets. A potential mechanism of cancer promotion, affected by insulin, has been linked to high IGF-I and lower IGF binding proteins (IGFBP) levels. Study 3 and 4 investigated the potential role in cancer risk of IGF components in bloodsamples of subsets of the endometrial and ovarian cancer studies. These casecontrol

Livia Silvia; Adriana Augustin; Livia Silvia; Adriana Augustin
2010-01-01

324

Identification of Tyrosine Residues in Constitutively Activated Fibroblast Growth Factor Receptor 3 Involved in Mitogenesis, Stat Activation, and

  CiteSeer

Summary: Fibroblast growth factor receptor 3 (FGFR3) mutations are frequently involved in human developmental disorders and cancer. Activation of FGFR3, through mutation or ligand stimulation, results in autophosphorylation of multiple tyrosine residues within the intracellular domain. To assess the importance of the six conserved tyrosine residues within the intracellular domain of FGFR3 for signaling, derivatives were constructed containing an N-terminal myristylation signal for plasma membrane localization and a point mutation (K650E) that confers constitutive kinase activation. A derivative containing all conserved tyrosine residues stimulates cellular transformation and activation of several FGFR3 signaling pathways. Substitution of all nonactivation loop tyrosine residues with phenylalanine rendered this FGFR3 construct inactive, despite the presence of the activating K650E mutation. Addition of a single tyrosine residue, Y724, restored its ability to stimulate cellular transformation, phosphatidylinositol 3-kinase activation, and phosphorylation of Shp2, MAPK, Stat1, and Stat3. These results demonstrate a critical role for Y724 in the activation of multiple signaling pathways by constitutively activated mutants of FGFR3.

Phosphatidylinositol -kinase Activation; Kristen C. Hart; Scott C. Robertson; Daniel J. Donoghue
2000-01-01

325

Effects of nutritional state on ghrelin, somatolactin, and the growth hormone and insulin-like growth factor axis in the tilapia, Oreochromis mossambicus.

  Open Access Theses and Dissertations

Summary: ??Mozambique tilapia (Oreochromis mossambicus) is an important aquaculture species that is cultured in tropical climates worldwide. Similar to terrestrial vertebrates, a functional growth hormone (GH)/insulin-like… (more)

Fox, Bradley K
2008-01-01

326

Growth Factors Wound Healing

  Mathematics Websites

Summary: with TGF- activity or signaling in genetically engineered mice, the researchers are mimicking of identified genetic polymorphisms linked to susceptibil- ity to diseases is steadily increasing in the wake with the avail- ability of tools for precise genetic modification enables a functional analysis of these disease

Schüler, Axel

327

Kinetics of surface roughening via pit growth during the oxidation of the basal plane of graphite. II. Theory and simulation

  Physics Websites

Summary: Kinetics of surface roughening via pit growth during the oxidation of the basal plane of graphite expressions for the description of the oxidation kinetics of the basal planes of the graphite surface of the graphite surface, as revealed by scanning tunneling microscopy, is discussed. INTRODUCTION THEORETICAL

Peters, Achim

328

Entropic Folding Pathway of Human Epidermal Growth Factor Explored by Disulfide Scrambling and Amplified Collective Motion Simulations,

  Biotechnology Websites

Summary: (denoted EGF-II) and that the native disulfide bonding pattern is less prevalent in one of the mutants-II exhibits two native disulfide bonds (Cys14-Cys31 and Cys33- Cys42), its large configurational entropy inhibits a direct transition to the native structure in the folding process. When Ser9 is mutated into Cys

Wriggers, Willy

329

A virus-induced mammalian growth with the characters of a tumor (the Shope rabbit papilloma). II. Experimental alterations of the growth on the skin: morphological considerations: the phenomena of retrogression

  CiteSeer

Summary: In Papers I and II the behavior and appearance of the papilloma under various circumstances have been described. They are those characterizing the tumors. Yet the cause of the growth is a filterable virus. Are there no distinguishing signs of its presence? This question will now be taken up. Concerning Inclusion Bodies The morphology of the growing or retrogressing papilloma does not suggest the presence of a virus. But in one important respect it has been insufficiently dealt with,--the possible presence within the affected epithelial cells of inclusion bodies such as occur in certain virus diseases has not been considered. Hurst (1) could find no inclusions but we have renewed the search and have compared the cytological findings with those in some epidermoid carcinomas of man and tar cancersofmice. The sections ofhumantumorswe owe to the kindness of several pathologists. A large variety of mouse tumors were available, deriving

Peyton Rous; J. W. Beard

330

Influence of environmental and climatic factors on the radial growth of European ash (Fraxinus excelsior L.) 1 The aim of the research was to evaluate the influence of various environmen-

  Environmental Sciences and Ecology Websites

Summary: excelsior L.) 1 The aim of the research was to evaluate the influence of various environmen- tal factors on the radial growth of European ash (Fraxinus excelsior L.). Six research plots were selected. Two of them were factors on the radial growth of European ash (Fraxinus excelsior L.) EKOLOGIJA. 2006. Nr. 1. P. 1


331

Endometriosis as a neurovascular condition: estrous variations in innervation, vascularization, and growth factor content of ectopic endometrial cysts

  Biology and Medicine Websites

Summary: and defined by vascularized endometrial growths outside the uterus. Endometriosis is produced in cycling rats by autotransplanting pieces of uterus onto abdominal arteries where they develop into cysts. The surgery induces) IS A CONDITION in women of childbearing age defined by the presence of endometrial growths outside the uterus

Berkley, Karen J.

332

H: TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res

  CiteSeer

Summary: It has long been postulated that protein tyrosine phosphatases may act as tumor suppressors because of their ability to counteract the oncogenic actions of protein tyrosine kinases. Here we report the cloning and char acterization of a novel human protein tyrosine phosphatase, TEP1. TEP1 contains the protein tyrosine phosphatase signature motif, and we show that it possesses an intrinsic protein tyrosine phosphatase activity. TEP1 also shares extensive homology with tensm, a cytoskeletal protein localized to focal adhesions, and with auxilin, a protein involved in synaptic vesicle transport. Immunofluorescence studies show that TEP1 is a cytoplasmic protein. The abundance of TEP1 transcription is altered in many trans formed cells. In the transforming growth factor fl-sensitive cells, TEP1 expression is rapidly down-regulated by transforming growth factor @1, a cytokine shown to be involved in regulating cell adhesion and cell motility. We have also mapped the gene encoding TEP1 to chromosome 10q23, a

Da-ming Li; Hong Sun; Cancer Res; Contact The Aacr Publications; Da-ming Li; Hong Sun
1997-01-01

333

Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty: the Whitehall II Prospective Cohort Study

  Computer Technologies and Information Sciences Websites

Summary: 1 Diabetes Risk Factors, Diabetes Risk Algorithms, and the Prediction of Future Frailty.ac.uk Running head Diabetes risk scores and frailty Key Words Ageing, frailty, diabetes risk scores, diabetes;2 Abstract Objective: To examine whether established diabetes risk factors and diabetes risk algorithms

Boyer, Edmond

334

Characterization of Cyclic and Separating Vectors and Application to an Inverse Problem in Modular Theory, II. Semifinite Factors

  Mathematical Physics (arXiv)

Summary: This paper generalizes the results obtained in an earlier paper (math.OA/0003087) for finite factors to infinite but still semifinite factors. First we give a characterization of cyclic and separating vectors for infinite semifinite factors in terms of operators associated with this vector and being affiliated with the factor. Further we show how this operator generates the modular objects of the given cyclic and separating vector generalizing an idea of Kadison and Ringrose. With the help of these results we can show that the second simple class of solutions for the inverse problem constructed in math.OA/0003087 never exists in infinite semifinite factors. Finally we give a classification of the solutions of the inverse problem in the case of modular operators having pure point spectrum, completely analoguous to the finite case.

Stefan Boller
2000-04-06

335

Charged pion form factor between Q^2=0.60 and 2.45 GeV^2. II. Determination of, and results for, the pion form factor

  CERN Preprints

Summary: The charged pion form factor, Fpi(Q^2), is an important quantity which can be used to advance our knowledge of hadronic structure. However, the extraction of Fpi from data requires a model of the 1H(e,e'pi+)n reaction, and thus is inherently model dependent. Therefore, a detailed description of the extraction of the charged pion form factor from electroproduction data obtained recently at Jefferson Lab is presented, with particular focus given to the dominant uncertainties in this procedure. Results for Fpi are presented for Q^2=0.60-2.45 GeV^2. Above Q^2=1.5 GeV^2, the Fpi values are systematically below the monopole parameterization that describes the low Q^2 data used to determine the pion charge radius. The pion form factor can be calculated in a wide variety of theoretical approaches, and the experimental results are compared to a number of calculations. This comparison is helpful in understanding the role of soft versus hard contributions to hadronic structure in the intermediate Q^2 regime.

Huber, G M; Horn, T; Beise, E J; Gaskell, D; Mack, D J; Tadevosyan, V; Volmer, J; Abbott, D; Aniol, K; Anklin, H; Armstrong, C; Arrington, J; Assamagan, K; Avery, S; Baker, O K; Barrett, B; Bochna, C; Boeglin, W; Brash, E J; Breuer, H; Chang, C C; Chant, N; Christy, M E; Dunne, J; Eden, T; Ent, R; Gibson, E; Gilman, R; Gustafsson, K; Hinton, W; Holt, R J; Jackson, H; Jin, S; Jones, M K; Keppel, C E; Kim, P H; Kim, W; King, P M; Klein, A; Koltenuk, D; Kovaltchouk, V; Kiang, M; Liu, J; Lolos, G J; Lung, A; Margaziotis, D J; Markowitz, P; Matsumura, A; McKee, D; Meekins, D; Mitchell, J; Miyoshi, T; Mkrtchyan, H; Müller, B; Niculescu, G; Niculescu, I; Okayasu, Y; Pentchev, L; Perdrisat, C; Pitz, D; Potterveld, D; Punjabi, V; Qin, L M; Reimer, P; Reinhold, J; Roche, J; Roos, P G; Sarty, A; Shin, I K; Smith, G R; Stepanyan, S; Tang, L G; Tvaskis, V; Van der Meer, R L J; Vansyoc, K; Van Westrum, D; Vidakovic, S; Vulcan, W; Warren, G; Wood, S A; Xu, C; Yan, C; Zhao, W -X; Zheng, X; Zihlmann, B
2008-01-01

336

Charged pion form factor between Q^2=0.60 and 2.45 GeV^2. II. Determination of, and results for, the pion form factor

  Nuclear Experiment (arXiv)

Summary: The charged pion form factor, Fpi(Q^2), is an important quantity which can be used to advance our knowledge of hadronic structure. However, the extraction of Fpi from data requires a model of the 1H(e,e'pi+)n reaction, and thus is inherently model dependent. Therefore, a detailed description of the extraction of the charged pion form factor from electroproduction data obtained recently at Jefferson Lab is presented, with particular focus given to the dominant uncertainties in this procedure. Results for Fpi are presented for Q^2=0.60-2.45 GeV^2. Above Q^2=1.5 GeV^2, the Fpi values are systematically below the monopole parameterization that describes the low Q^2 data used to determine the pion charge radius. The pion form factor can be calculated in a wide variety of theoretical approaches, and the experimental results are compared to a number of calculations. This comparison is helpful in understanding the role of soft versus hard contributions to hadronic structure in the intermediate Q^2 regime.

G. M. Huber; H. P. Blok; T. Horn; E. J. Beise; D. Gaskell; D. J. Mack; V. Tadevosyan; J. Volmer; D. Abbott; K. Aniol; H. Anklin; C. Armstrong; J. Arrington; K. Assamagan; S. Avery; O. K. Baker; B. Barrett; C. Bochna; W. Boeglin; E. J. Brash; H. Breuer; C. C. Chang; N. Chant; M. E. Christy; J. Dunne; T. Eden; R. Ent; E. Gibson; R. Gilman; K. Gustafsson; W. Hinton; R. J. Holt; H. Jackson; S. Jin; M. K. Jones; C. E. Keppel; P. H. Kim; W. Kim; P. M. King; A. Klein; D. Koltenuk; V. Kovaltchouk; M. Kiang; J. Liu; G. J. Lolos; A. Lung; D. J. Margaziotis; P. Markowitz; A. Matsumura; D. McKee; D. Meekins; J. Mitchell; T. Miyoshi; H. Mkrtchyan; B. Mueller; G. Niculescu; I. Niculescu; Y. Okayasu; L. Pentchev; C. Perdrisat; D. Pitz; D. Potterveld; V. Punjabi; L. M. Qin; P. Reimer; J. Reinhold; J. Roche; P. G. Roos; A. Sarty; I. K. Shin; G. R. Smith; S. Stepanyan; L. G. Tang; V. Tvaskis; R. L. J. van der Meer; K. Vansyoc; D. Van Westrum; S. Vidakovic; W. Vulcan; G. Warren; S. A. Wood; C. Xu; C. Yan; W. -X. Zhao; X. Zheng; B. Zihlmann
2008-09-18

337

K: Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons

  CiteSeer

Summary: Numerous studies have suggested that glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic molecule. We show now on a variety of cultured neurons including peripheral autonomic, sensory, and CNS dopaminergic neurons that GDNF is not trophically active unless supplemented with TGF-?. Immunoneutralization of endogenous TGF- ? provided by serum or TGF-?-secreting cells, as e.g., neurons, in culture abolishes the neurotrophic effect of GDNF. The dose–response relationship required for the synergistic effect of GDNF and TGF- ? identifies 60 pg/ml of either factor combined with 2 ng/ml of the other factor as the EC 50. GDNF/TGF- ? signaling employs activation of phosphatidylinositol-3 (PI-3) kinase as an intermediate step as shown by the effect of the specific PI-3 kinase inhibitor wortmannin. The synergistic action of GDNF and TGF- ? involves protection of glycosylphosphatidylinositol

Kerstin Krieglstein; Prisca Henheik; Lilla Farkas; Jozsef Jaszai; Dagmar Galter; Knut Krohn; Klaus Unsicker
1998-01-01

338

Migration and Growth of Protoplanetary Embryos II: Emergence of Proto-Gas-Giants Cores versus Super Earths' Progenitor

  CERN Preprints

Summary: Nearly $15-20%$ of solar type stars contain one or more gas giant planet. According to the core-accretion scenario, the acquisition of their gaseous envelope must be preceded by the formation of super-critical cores with masses ten times or larger than that of the Earth. It is natural to link the formation probability of gas giant planets with the supply of gas and solid in their natal disks. However, a much richer population of super Earths suggests that 1) there is no shortage of planetary building-block material, 2) gas giants' growth barrier is probably associated with whether they can merge into super-critical cores, and 3) super Earths are probably failed cores which did not attain sufficient mass to initiate efficient accretion of gas before it is severely depleted. Here we construct a model based on the hypothesis that protoplanetary embryos migrated extensively before they were assembled into bona fide planets. We construct a Hermite-Embryo code based on a unified viscous-irradiation disk model and a...

Liu, Beibei; Lin, Douglas N C; Aarseth, Sverre J
2014-01-01

339

Stern, C.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In: Hepatocyte Growth Factor -Scatter Factor (HGF-SF) and the c-MET receptor. (ed. I.D. Goldberg and E. Rosen) Basel: Birkhauser Verlag. pp. 369-380.

  Biology and Medicine Websites

Summary: Stern, C.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In inducing molecule in vertebrate embryos? In: Hepatocyte Growth Factor - Scatter Factor (HGF- SF) and the c.D. and Ireland, G.W. (1993) HGF/SF: a neural inducing molecule in vertebrate embryos? In: Hepatocyte Growth

Stern, Claudio

340

In vitro regulation of porcine Leydig cell steroidogenesis by epidermal growth factor (EGF) and transforming growth factor alpha (TGFa) and the immunolocalization of TGFa in the immature porcine testis

  Texas A&M University - TxSpace

Summary: OF CELL CULTURE SOLUTIONS. . . 61 APPENDIX C: STEROID RADIOIMMUNOASSAY PROTOCOL. . . . . . . 63 APPENDIX D: STEROID RADIOIMMUNOASSAY SOLUTIONS. . . . 65 Page APPENDIX E: IMMUNOHISTOCHEMISTRY METHODOLOGY. . . . . . 67 APPENDIX F: PREPARATION... hormone (LH), follicle stimulating hormone (FSH), growth hormone (GH) and prolactin (Bellve and Zheng, 1989). LH release is controlled by a complex interaction of the sex steroids and hypothalamic gonadotoropin releasing hormone (GnRH). In the mature...

Blackwell, Jenna Lynne
2012-06-07

341

Form-factors in the Baxter-Bazhanov-Stroganov model II: Ising model on the finite lattice

  Mathematical Physics (arXiv)

Summary: We continue our investigation of the Baxter-Bazhanov-Stroganov or \\tau^{(2)}-model using the method of separation of variables [nlin/0603028,arXiv:0708.4342]. In this paper we derive for the first time the factorized formula for form-factors of the Ising model on a finite lattice conjectured previously by A.Bugrij and O.Lisovyy in [arXiv:0708.3625,arXiv:0708.3643]. We also find the matrix elements of the spin operator for the finite quantum Ising chain in a transverse field.

G. von Gehlen; N. Iorgov; S. Pakuliak; V. Shadura; Yu. Tykhyy
2007-11-03

342

Protein Engineering vol 1 no 5 pp 399-406, 1987 Solution conformations of human growth hormone releasing factor

  Biology and Medicine Websites

Summary: releasing factor: comparison of the restrained molecular dynamics and distance geometry methods for a system factor in trifluoroethanoJ have been determined by molecular dynamics and distance geometry methods simulations, the NOE data were not sufficient for global con- vergence to a unique three-dimensional geometry

Clore, G. Marius

343

Abstract N is often cited as a limiting factor for sapling growth in northeastern USA forests. However, under

  Environmental Sciences and Ecology Websites

Summary: (Odocoileus virginianus L.). We con- ducted a field fertilization experiment to test the hypoth- esis that saplings increase stem tissue N when soil N availability is elevated. We fertilized saplings of nine tree) and black cherry (Prunus serotina), had significant increases in radial growth when fertilized under high


344

Effect of animal protein factor (APF) and antibiotics on the growth responses and general appearance of young dairy calves

  Texas A&M University - TxSpace

Summary: . Cunha? Hs go Hdwards and C. 8 Qeadows. growth promoting effects of aur~?u?tu?in on pigs, Arch. NiocIwaa. 26? 324, 19% ~ 23, Jaoobson? N, L, raper pres *nted at Am ric?n 'ocisty for Animal ?roduction lIeetln, ;s? November? 19'ql ~ Johnson? I' ~ I...

Seminario, Carlos
1952-01-01

345

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

  MIT - DSpace

Summary: The mammalian target of rapamycin (mTOR) protein kinase is a master growth promoter that nucleates two complexes, mTORC1 and mTORC2. Despite the diverse processes controlled by mTOR, few substrates are known. We defined ...

Rameseder, J.

346

Printed in U.S.A. Copyright © 2000 by The Endocrine Society Activation of a Uterine Insulin-Like Growth Factor I Signaling Pathway by Clinical and Environmental

  CiteSeer

Summary: Recent data indicate that insulin-like growth factor I (IGF-I) may have a function in mediating the mitogenic effects of 17?-estradiol (E 2) in the uterus and in regulating the growth of uterine neoplasms. This study was designed to determine whether synthetic and plantderived chemicals that interact with estrogen receptor- ? (ER?) and elicit estrogenic responses also mimic E 2 by activating the uterine IGF-I signaling pathway. Ovariectomized adult female mice were treated with both environmental and clinically relevant chemicals previously reported to display estrogenic and/or antiestrogenic properties, and their uteri were evaluated for an activated IGF-I signaling pathway. Diethylstilbestrol, 4-hydroxytamoxifen, the raloxifene analog LY353381, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), bisphenol A, and genistein were shown to mimic E 2 in the uterus by increasing the level of IGF-I messenger RNA, inducing IGF-I receptor

Estrogens Requirement; Estrogen Receptor; Diane M. Klotz; Sylvia Curtis Hewitt; Kenneth S. Korach; Richard P. Diaugustine
2000-01-01

347

Diffusion Dynamics during the Nucleation and Growth of Ge=Si Nanostructures on Si(111) F. Ratto,1,*,

  Materials Science Websites

Summary: , with a view to applications in micro- and optoe- lectronics. The growth of germanium on low index silicon simulations, three- dimensional islands are shown to display a substantial tendency towards self nuclei display a tendency towards self-ordering? (ii) What factors govern the relative growth


348

Supersymmetry and the Atiyah-Singer Index Theorem II: The Scalar Curvature Factor in the Schr{\\" o}dinger Equation

  HEP - Theory (arXiv)

Summary: The quantization of the superclassical system used in the proof of the index theorem results in a factor of $\\hbar^{2}R/8 $ in the Hamiltonian. The path integral expression of the kernel is analyzed up to and including 2-loop order. The existence of the scalar curvature term is confirmed by comparing the linear term in the heat kernel expansion with the 2-loop order terms in the loop expansion.

Ali Mostafazadeh
1993-09-10

349

Factorization of non-linear supersymmetry in one-dimensional Quantum Mechanics. II: proofs of theorems on reducibility

  CERN Preprints

Summary: In this paper, we continue to study factorization of supersymmetric (SUSY) transformations in one-dimensional Quantum Mechanics into chains of elementary Darboux transformations with nonsingular coefficients. We define the class of potentials that are invariant under the Darboux - Crum transformations and prove a number of lemmas and theorems substantiating the formulated formerly conjectures on reducibility of differential operators for spectral equivalence transformations. Analysis of the general case is performed with all the necessary proofs.

Sokolov, A V
2009-01-01

350

Factorization of non-linear supersymmetry in one-dimensional Quantum Mechanics. II: proofs of theorems on reducibility

  Mathematical Physics (arXiv)

Summary: In this paper, we continue to study factorization of supersymmetric (SUSY) transformations in one-dimensional Quantum Mechanics into chains of elementary Darboux transformations with nonsingular coefficients. We define the class of potentials that are invariant under the Darboux - Crum transformations and prove a number of lemmas and theorems substantiating the formulated formerly conjectures on reducibility of differential operators for spectral equivalence transformations. Analysis of the general case is performed with all the necessary proofs.

A. V. Sokolov
2009-03-16

351

In vitro model of injury/cytokine-induced cartilage catabolism modulated by dynamic compression, growth factors, and glucocorticoids

  MIT - DSpace

Summary: The degradation of articular cartilage is the hallmark in the pathogenesis of osteoarthritis (OA). It still remains largely unknown which precise mechanisms initiate cartilage degradation. However, risks factors include ...

Li, Yang, Ph. D. Massachusetts Institute of Technology
2013-01-01

352

A Macro- and Micro-Designed Chitosan-Alginate Scaffold with Sustained Growth Factor Release for Chondrogenesis

  University of California eScholarship Repository

Summary: followed by immobilization of stromal cell-derived factor-immobilization of RGDS on hydrogel surfaces to direct cellimmobilization of interferon-gamma induces neuronal differentiation of neural stem cells.

Reed, Stephanie
2014-01-01

353

Use of growth factors and adhesive ligands to promote connective tissue progenitor colony formation from fresh marrow

  MIT - DSpace

Summary: The current gold standard for bone graft material is autologous bone, which provides mechanical support, possesses factors that promote bone formation, and contains connective tissue progenitors (CTPs), a heterogeneous ...

Marcantonio, Nicholas A. (Nicholas Alexander)
2008-01-01

354

Partner orbits and action differences on compact factors of the hyperbolic plane. Part II: Higher-order encounters

  Mathematical Physics (arXiv)

Summary: We continue considering the geodesic flow on compact factors of the hyperbolic plane. In the first part of this paper [10], we proved the existence of a unique periodic partner orbit for a given periodic orbit with a small-angle self-crossing in configuration space which is a `2-encounter' and we derived an estimate for the action difference of the orbit pair. In this part, we provide an inductive argument to deal with higher-order encounters. We construct partner orbits and give estimates for the action differences between orbit pairs.

Hien Minh Huynh
2015-01-18

355

Enhanced expression of hepatocyte growth factor by pulmonary ischemia-reperfusion injury in the rat. Am J Respir Crit Care Med

  CiteSeer

Summary: Hepatocyte growth factor (HGF) has recently been noted to function as a pulmotrophic factor for lung regeneration. The present study was conducted to determine if HGF would be induced in a rat model of pulmonary ischemia–reperfusion (IR) injury, which was established by occlusion of the left lung, and to examine the significance of HGF in subsequent lung repair. The sham-operated rats underwent simple thoracotomy in which the lung was not clamped. We measured the plasma and the tissue levels of HGF by enzyme-linked immunosorbent assays, and the expression of HGF mRNA by Northern blotting. The plasma HGF level was markedly elevated after pulmonary ischemia and reached the peak value on the third postoperative day, being 5-fold higher than that of the sham-operated rats. HGF mRNA expression and the tissue HGF levels were augmented twofold in the ischemic reperfused lung. Immunohistochemical analysis revealed that the infiltrating alveolar

Takatsugu Yamada; Michiyoshi Hisanaga; Yoshiyuki Nakajima; Shinya Mizuno; Kunio Matsumoto

356

THE REGULATION OF PINOCYTOSIS IN MOUSE MACROPHAGES II. FACTORS INDUCmO V~SICLV. FOP.MATION*

  CiteSeer

Summary: A prior study outlined a microscopic technique with which one could quantitate the formation of pinocytic vesicles in cultured mouse macrophages (1). Under these conditions it was evident that vesicle formation responded promptly to factors contained in newborn calf serum. In addition, through the use of metabolic inhibitors, it was possible to examine certain of the determinants involved in pinosome formation. Largely through the efforts of Holter and his colleagues an increasing body of knowledge has accumulated on the mechanism of pinocytosis in the amoeba (2, 3). A portion of these investigations has been concerned with the induction of channel formation and the resulting uptake of both small and large molecules from the external environment (4). In general, only charged molecules function as effective stimulators of pinocytosis and these are all thought to bind to the surface coat of the amoeba (5). With the previous studies of the Carlsberg group as a guideline and with the knowledge that newborn calf serum contained pinocytosis-stimulating factors,

Bx Zanvil; A. Cohn; Eileen Parks
1966-01-01

357

Nutritional and environmental factors affecting germination, growth, and sporulation of Pithomyces chartarum (Berk. & Curt.) M. B. Ellis

  Texas A&M University - TxSpace

Summary: , growth, and sporulation. Three isolates were used in this research, two from Texas and one from New Zealand. Germination required air and moisture, and several germ tubes were able to form per spore within a few hours. Spores were able to germinate...- desmin (65). This fungus has caused economic losses to ranchers in New Zealand since 1908 when the disease was first described by J. A. Gi. lruth (21) a New Zealand veterinarian. The disease caused loss in weight of animals and skin lesions on the face...

Whitlock, Larry Lee
2012-06-07

358

POLYAMINES INCREASE IN SYMPATHETIC NEURONS AND NON- NEURONAL CELLS AFTER AXOTOMY AND ENHANCE NEURITE OUTGROWTH IN NERVE GROWTH FACTOR-PRIMED PC12 CELLS

  CiteSeer

Summary: Abstract—Following axonal damage, sympathetic neurons are capable of regenerating and reinnervating their target tissues. Some years ago exogenous administration of polyamines was shown to enhance this regeneration. Recently, it was found that axonal injury leads to a dramatic up-regulation of the expression of arginase I in sympathetic neurons. This enzyme catalyzes the conversion of arginine to ornithine, which can subsequently be converted to the diamine putrescine and, ultimately, to the polyamines spermidine and spermine. In the present study, using an antiserum that reacts with both spermidine and spermine, we have found an increase in polyamine levels in both neurons and non-neuronal cells in the superior cervical ganglion 2 and 5 days following transection of the ganglion’s postganglionic trunks. Using PC12 cells primed with nerve growth factor and then stripped off the culture dish and replated as a model system for axotomized sympathetic neurons, we found that spermidine treatment, with or without nerve growth factor, resulted in an increased percentage of cells with a neurite whose length was at least twice the diameter of the neuron’s cell body. These increases could be seen within 48 h and were still evident after 8 days. Together, these data support the possibility that endogenous polyamines are involved in the normal regeneration which occurs following sympathetic axonal damage. © 2004 IBRO. Published by Elsevier Ltd. All rights reserved.

R. C. Schreiber; A K. L. Boeshore; A G. Laube; R. W. Veh B; R. E. Zigmond A

359

Printed in U.S.A. Copyright © 1998 by The Endocrine Society Nerve Growth Factor Processing and Trafficking Events Following TrkA-Mediated Endocytosis*

  CiteSeer

Summary: We expressed the high affinity nerve growth factor receptor TrkA in Chinese hamster ovary (CHO) fibroblasts to study nerve growth factor (NGF) trafficking and processing events following receptormediated ligand internalization in a nonneuronal and p75 minus cell line. These stable clonal cell lines express approximately 2.5 ? 10 5 TrkA receptors and bind 125 I-NGF with high affinity (K d ? 4 ? 10 ?10 M). The TrkA receptors are autophosphorylated on tyrosine residues upon NGF stimulation and are capable of tyrosine phosphorylating downstream signaling molecules. The t 1/2 of 125 I-NGF internalization is 5 min, and the probability of an occupied TrkA receptor internalizing within 1 min at 37 C is 9.8%. By 2 h following endocytosis, less than 10 % of internalized 125 I-NGF is degraded, as determined by TCA precipitation. Thirty minutes following ligand endocytosis, endocytosed 125 I-NGF is delivered back to the cell surface and released by the cell (retroendocytosis), possibly by remaining associated with recycling TrkA receptors. We measured the effect of acidification on

Antje Zapf-colby; Jerrold; M. Olefsky
1998-01-01

360

Cells respond to extracellular cues via receptor signaling. In this manner, cellular behavior is under strict control of hormones, growth factors or neurotransmitters. Binding of a ligand to its cognate receptor triggers

  Physics Websites

Summary: behavior is under strict control of hormones, growth factors or neurotransmitters. Binding of a ligand branch into different series of molecular conversions leading to, for instance, activation of transcription factors, regulation of metabolic processes or changes in cell morphology. To regulate

van den Brink, Jeroen

361

350 nature neuroscience volume 3 no 4 april 2000 Neurotrophins are a family of growth factors regulating the sur-

  Biology and Medicine Websites

Summary: -derived neurotrophic factor (BDNF)4, neurotrophin-3 (NT3)5­9 and neurotrophin-4/5 (NT4)10,11. The diverse functions: NGF signals through the TrkA receptor, both BDNF and NT4 bind to the TrkB receptor, and NT3 interacts largely overlapping neuronal deficits14. Although both NT4 and BDNF bind to the TrkB and p75NTR receptors


362

Cell contact–dependent immunosuppression by CD4 ? CD25 ? regulatory T cells is mediated by cell surface-bound transforming growth factor beta

  CiteSeer

Summary: CD4 ? CD25 ? T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4 ? CD25 ? T cells by cell–cell contact and not secretion of suppressor cytokines. In this study, we demonstrated that CD4 ? CD25 ? T cells do produce high levels of transforming growth factor (TGF)-?1 and interleukin (IL)-10 compared with CD4 ? CD25 ? T cells when stimulated by plate-bound anti-CD3 and soluble anti-CD28 and/or IL-2, and secretion of TGF-?1 (but not other cytokines), is further enhanced by costimulation via cytotoxic T lymphocyte–associated antigen (CTLA)-4. As in prior studies, we found that CD4 ? CD25 ? T cells suppress proliferation of CD4 ? CD25 ? T cells; however, we observed here that such suppression is abolished by the presence of anti–TGF-?. In addition, we found that CD4 ? CD25 ? T cells suppress B cell immunoglobulin production and that anti–TGF-? again abolishes such suppression. Finally, we found that stimulated CD4 ? CD25 ? T cells but not CD4 ? CD25 ? T cells express high and persistent levels of TGF-?1 on the cell surface. This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4 ? CD25 ? T cells exert immunosuppression by a cell–cell interaction involving cell surface TGF-?1. Key words: T lymphocytes, suppressor-effector • CD4-positive T lymphocytes • receptors, interleukin 2 • transforming growth factors • autoimmune diseases

Kazuhiko Nakamura; Atsushi Kitani; Warren Strober
2001-01-01

363

Transgenic Mice Expressing a B Cell Growth and Differentiation Factor Gene (Interleukin 5) Develop Eosinophilia and Autoantibody Production

  CiteSeer

Summary: Interleukin 5 (1175) has been suggested to be involved in the growth and differentiation of B cells and eosinophils. Especially, Ly-1+ B cells, which have been considered to produce autoantibodies, are selectively developed by this lymphokine in long-term bone marrow culture. To envisage the possible engagement of IL5 in the development of these cells in vivo, transgenic mice carrying the mouse IL5 gene ligated with a metallothionein promoter were generated. Transgenic mice carrying the 1175 gene exhibited elevated levels of 11,5 in the serum and an increase in the levels of serum IgM and IgA. A massive eosinophilia in peripheral blood, bone marrow, and spleen, and an infiltration ofmuscle and liver with eosinophils, were observed. When cadmiumcontaining saline was injected intraperitoneally into transgenic mice, IM production was augmented about five times within 24 h, and a distinctive Ly-1 + B cell population became apparent in the spleen after 5 d. 1175 receptors were detected on those cells by monoclonal antibodies against IL-5 receptors. Another interesting finding in these transgenic mice was an increase in polyreactive anti-DNA antibodies of IgM class. It is suggested, therefore, that aberrant expression of the IL5 gene may induce accumulation of Ly-1+ B cells and eosinophils. Furthermore, this IL5 transgenic mouse can be a model mouse for eosinophilia, and we can determine the role of IL5

Akira Tominaga; Satoshi Takaki; Nobuo Koyama; Shigeki Katoh; Ryoji Matsumoto; Masahiro Migita; Yasumichi Hitoshi; Yukio Hosoya; Shigehito Yamauchij; Yoshiyuki Kanai; Kiyoshi Takatsu

364

Large-scale growth evolution in the Szekeres inhomogeneous cosmological models with comparison to growth data

  General Relativity & Quantum Cosmology (arXiv)

Summary: We use the Szekeres inhomogeneous cosmological models to study the growth of large-scale structure in the universe including nonzero spatial curvature and a cosmological constant. In particular, we use the Goode and Wainwright formulation, as in this form the models can be considered to represent exact nonlinear perturbations of an averaged background. We identify a density contrast in both classes I and II of the models, for which we derive growth evolution equations. By including Lambda, the time evolution of the density contrast as well as kinematic quantities can be tracked through the matter- and Lambda-dominated cosmic eras up to the present and into the future. In various models of class I and class II, the growth rate is found to be stronger than that of the LCDM cosmology, and it is suppressed at later times due to the presence of Lambda. We find that there are Szekeres models able to provide a growth history similar to that of LCDM while requiring less matter content and nonzero curvature, which speaks to the importance of including the effects of large-scale inhomogeneities in analyzing the growth of large-scale structure. Using data for the growth factor f from redshift space distortions and the Lyman-alpha forest, we obtain best fit parameters for class II models and compare their ability to match observations with LCDM. We find that there is negligible difference between best fit Szekeres models with no priors and those for LCDM, both including and excluding Lyman-alpha data. We also find that the growth index gamma parametrization cannot be applied in a simple way to the growth in Szekeres models, so a direct comparison of the function f to the data is performed. We conclude that the Szekeres models can provide an exact framework for the analysis of large-scale growth data that includes inhomogeneities and allows for different interpretations of observations. (abridged)

Austin Peel; Mustapha Ishak; M. A. Troxel
2012-12-11

365

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor

  CiteSeer

Summary: Abstract. Cultured human embryonic lung fibroblasts were used as a model to study the effects of transforming growth factor-13 (TGFI3) on the plasminogen activator (PA) activity released by nontumorigenic cells into the culture medium. The cells were exposed to TGFfl under serum-free conditions, and the changes in PA activity and protein metabolism were analyzed by caseinolysis-in-agar assays, zymography, and polypeptide analysis. Treatment of the cells with TGFI ~ caused a significant decrease in the PA activity of the culture medium as analyzed by the caseinolysis-in-agar assays. The quantitatively most prominent effect of TGFI3 on confluent cultures of ceils was the induction of an Mr 47,000 protein, as detected by metabolic labeling. The Mr 47,000 protein was a PA inhibitor as judged by re-

Marikki Laiho; Oui Saksela; Peter A. Andreasen; Jorma Keski-oja
1986-01-01

366

growth factor-?1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell 12: 27–36

  CiteSeer

Summary: Transforming growth factor-?1 (TGF-?) can be tumor suppressive, but it can also enhance tumor progression by stimulating the complex process of epithelial-to-mesenchymal transdifferentiaion (EMT). The signaling pathway(s) that regulate EMT in response to TGF- ? are not well understood. We demonstrate the acquisition of a fibroblastoid morphology, increased N-cadherin expression, loss of junctional E-cadherin localization, and increased cellular motility as markers for TGF-?– induced EMT. The expression of a dominant-negative Smad3 or the expression of Smad7 to levels that block growth inhibition and transcriptional responses to TGF- ? do not inhibit mesenchymal differentiation of mammary epithelial cells. In contrast, we show that TGF- ? rapidly activates RhoA in epithelial cells, and that blocking RhoA or its downstream target p160 ROCK,bythe expression of dominant-negative mutants, inhibited TGF-?–mediated EMT. The data suggest that TGF- ? rapidly activates RhoA-dependent signaling pathways to induce stress fiber formation and mesenchymal characteristics.

Neil A. Bhowmick; Mayshan Ghiassi; Andrei Bakin; Mary Aakre; Christopher A. Lundquist; Michael E. Engel; Carlos L. Arteaga; Harold L. Moses
2001-01-01

367

Exchange Driven Growth

  Condensed Matter (arXiv)

Summary: We study a class of growth processes in which clusters evolve via exchange of particles. We show that depending on the rate of exchange there are three possibilities: I) Growth: Clusters grow indefinitely; II) Gelation: All mass is transformed into an infinite gel in a finite time; and III) Instant Gelation. In regimes I and II, the cluster size distribution attains a self-similar form. The large size tail of the scaling distribution is Phi(x) ~ exp(-x^{2-\

E. Ben-Naim; P. L. Krapivsky
2003-05-08

368

Printed in U.S.A. Copyright © 1997 by The Endocrine Society Transient Exposure of Human Myoblasts to Tumor Necrosis Factor- ? Inhibits Serum and Insulin-Like Growth Factor-I Stimulated Protein Synthesis*

  CiteSeer

Summary: Tumor necrosis factor- ? (TNF-?) induces cachexia and is postulated to be responsible for muscle wasting in several pathophysiological conditions. The purpose of the present study was to investigate whether exposure of human myoblasts to TNF- ? could directly inhibit the ability of serum or insulin-like growth factor I (IGF-I) to stimulate protein synthesis as assessed by the incorporation of [ 3 H]phenylalanine into protein. Serum and IGF-I stimulated protein synthesis dose dependently. Half-maximal stimulation of protein synthesis occurred at 05 % serum and 8 ng/ml of IGF-I, respectively. TNF- ? inhibited IGF-I-stimulated protein synthesis in a dose-dependent manner. Additionally, as little as 2 ng/ml of TNF- ? impaired the ability of IGF-I to stimulate protein synthesis by 33 % and, at a dose of 100 ng/ml, TNF- ? completely prevented the increase in protein synthesis induced by either serum or a maximally stimulating dose of IGF-I.

Robert A. Frost; Charles H. Lang; Marie; C. Gelato

369

Fetal Exposure to Altered Amniotic Fluid Glucose, Insulin, and Insulin-Like Growth Factor–Binding Protein 1 Occurs Before Screening for Gestational Diabetes Mellitus

  CiteSeer

Summary: OBJECTIVE — We explored the possibility that perturbations in amniotic fluid glucose, insulin, and insulin-like growth factor–binding protein 1(IGFBP1) and/or metabolic acids exist before routine screening for GDM. RESEARCH DESIGN AND METHODS — We selected consenting mother-infant pairs (n ? 408) who met our inclusion criteria (singleton pregnancy, no genetic abnormalities, and no preexisting diabetes) and for whom sufficient amniotic fluid and appropriate medical information were available. We compared birth outcomes and second trimester amniotic fluid glucose, insulin, IGFBP1 concentrations, and amniotic fluid lactic, ?-hydroxybutyric, and uric acids of mothers with gestational diabetes mellitus (GDM) (n ? 52) with those of mothers with no diagnosis of GDM at ?24 weeks (n ? 356). RESULTS — Higher amniotic fluid glucose, lactic acid, uric acid, and insulin and lower IGFBP1 concentrations were present by 15.1 ? 0.1 weeks in mothers in whom GDM was subsequently diagnosed. However, logistic regression showed that second trimester amniotic fluid glucose, but not insulin, IGFBP1, or metabolic acids was associated with an increased odds ratio (1.2 [95 % CI 1.052–1.338]) for diagnosis of GDM at 24–28 weeks. In addition, probability

Daniel K. Tisi; David H. Burns; Gary W. Luskey; Kristine G. Koski

370

1 Specificity Protein 1 and Smad-Dependent Regulation of Human Heme Oxygenase-1 Gene by Transforming Growth Factor-?1 in Renal Epithelial Cells *

  CiteSeer

Summary: Excess transforming growth factor-?1 (TGF-?1) in the kidney leads to increased cell proliferation and deposition of extracellular matrix, resulting in progressive kidney fibrosis. TGF-?1, however, stabilizes and attenuates tissue injury through the activation of cytoprotective proteins, including heme oxygenase-1 (HO-1). HO-1 catabolizes pro-oxidant heme into substances with anti-oxidant, anti-apoptotic, anti-fibrogenic, vasodilatory and immune modulatory properties. Little is known regarding the molecular regulation of human HO-1 induction by TGF-?1 except that it is dependent on de novo RNA synthesis and requires a group of structurally related proteins called Smads. It is not known if other DNA binding proteins are required to initiate transcription of HO-1 and, furthermore, the promoter region(s) involved in TGF-?1-mediated induction of HO-1 has not been identified. The purpose of this study was to further delineate the molecular regulation of HO-1 by TGF-?1 in human renal proximal tubular cells. Actinomycin D and nuclear run-on studies demonstrate that TGF-?1 augments HO-1 expression by increased gene transcription and does not involve increased mRNA stability. Using transient transfection, mithramycin A, small interfering RNA, electrophoretic mobility shift assays and decoy oligonucleotide experiments, a TGF-?1-responsive region is identified between 9.1 and 9.4kb of the human HO-1

Amie Traylor; Thomas Hock; Nathalie Hill-kapturczak

371

? v ? 3 Integrin Mediates the Cell-adhesive Capacity and Biological Activity of Basic Fibroblast Growth Factor (FGF-2) in Cultured Endothelial Cells

  CiteSeer

Summary: Fibroblast growth factor-2 (FGF-2) immobilized on non-tissue culture plastic promotes adhesion and spreading of bovine and human endothelial cells that are inhibited by anti-FGF-2 antibody. Heat-inactivated FGF-2 retains its cell-adhesive activity despite its incapacity to bind to tyrosine-kinase FGF receptors or to cell-surface heparan sulfate proteoglycans. Recombinant glutathione-S-transferase-FGF-2 chimeras and synthetic FGF-2 fragments identify two cell-adhesive domains in FGF-2 corresponding to amino acid sequences 38–61 and 82–101. Both regions are distinct from the FGF-receptor-binding domain of FGF-2 and contain a DGR sequence that is the inverse of the RGD cell-recognition sequence. Calcium deprivation, RGD-containing eptapeptides, soluble vitronectin (VN), but not fibronectin (FN), inhibit cell adhesion to FGF-2. Conversely, soluble FGF-2 prevents cell adhesion to VN but not FN, thus implicating VN receptor in the cell-adhesive activity of FGF-2. Accordingly, monoclonal and polyclonal anti- ? v ? 3 antibodies prevent cell adhesion to FGF-2. Also, purified human ? v ? 3 binds to immobilized FGF-2 in a cation-dependent manner, and this interaction is competed by soluble VN but not by soluble FN. Finally, anti- ? v ? 3 monoclonal and polyclonal antibodies specifically inhibit mitogenesis and urokinase-type plasminogen

Marco Rusnati; Elena Tanghetti; Anna Gual; Marco Presta; Mosatoshi Takeichi
1996-01-01

372

Molecular beam epitaxy growth and characterization of broken-gap ,,type II... superlattices and quantum wells for midwave-infrared laser diodes

  Physics Websites

Summary: type-II MWIR laser development work em- ployed multiple quantum well MQW samples with InAs/ GaInSb indepen- dently vary the thicknesses of the two constituent layers as well as the composition of the GaInSb, the suppression of AR and ISBA was some- what limited with the two-layer BGSL structure.4 Therefore the InAs/GaInSb

Flatte, Michael E.

373

Ets-1 Is Essential for Connective Tissue Growth Factor (CTGF/CCN2) Induction by TGF-b1 in Osteoblasts

  CiteSeer

Summary: Background: Ets-1 controls osteoblast differentiation and bone development; however, its downstream mechanism of action in osteoblasts remains largely undetermined. CCN2 acts as an anabolic growth factor to regulate osteoblast differentiation and function. CCN2 is induced by TGF-b1 and acts as a mediator of TGF-b1 induced matrix production in osteoblasts; however, the molecular mechanisms that control CCN2 induction are poorly understood. In this study, we investigated the role of Ets-1 for CCN2 induction by TGF-b1 in primary osteoblasts. Results: We demonstrated that Ets-1 is expressed and induced by TGF-b1 treatment in osteoblasts, and that Ets-1 overexpression induces CCN2 protein expression and promoter activity at a level similar to TGF-b1 treatment alone. Additionally, we found that simultaneous Ets-1 over-expression and TGF-b1 treatment synergize to enhance CCN2 induction, and that CCN2 induction by TGF-b1 treatment was impaired using Ets-1 siRNA, demonstrating the requirement of Ets-1 for CCN2 induction by TGF-b1. Site-directed mutagenesis of eight putative Ets-1 motifs (EBE) in the CCN2 promoter demonstrated that specific EBE sites are required for CCN2 induction, and that mutation of EBE sites in closer proximity to TRE or SBE (two sites previously shown to regulate CCN2 induction by TGF-b1) had a greater effect on CCN2 induction, suggesting potential synergetic interaction among these sites for CCN2 induction. In addition, mutation of EBE sites prevented protein complex binding, and this protein complex formation was also inhibited by addition of Ets-1 antibody or Smad 3 antibody,

Max T. Geisinger; Y Astaiza; Tiffany Butler; Steven N. Popoff; Sonia Lobo Planey; John A. Arnott

374

Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: Biochemical characterization and biological consequences in endothelial cell cultures. Molecular Biology of the Cell

  CiteSeer

Summary: Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor-2 (FGF-2), but their mechanism of action has not been elucidated. Here, a possible direct interaction of sialo-glycolipids with FGF-2 has been investigated. Size exclusion chromatography demonstrates that native, but not heat-denatured, 125I-FGF-2 binds to micelles formed by gangliosides GT1b, GD1b, orGM1. Also, gangliosides protect native FGF-2 from trypsin digestion at micromolar concentrations, the order of relative potency being GT1b ? GD1b ? GM1 ? GM2 ? sulfatide ? GM3 ? galactosyl-ceramide, whereas asialo-GM1, neuraminic acid, and N-acetylneuramin-lactose were ineffective. Scatchard plot analysis of the binding data of fluorochrome-labeled GM1 to immobilized FGF-2 indicates that FGF–2/GM1 interaction occurs with a Kd equal to 6 ?M. This interaction is inhibited by the sialic acid-binding peptide mastoparan and by the synthetic fragments FGF-2(112–129) and, to a lesser extent, FGF-2(130–155), whereas peptides FGF-2(10–33), FGF-2(39–59), FGF-2(86–96), and the basic peptide HIV-1 Tat(41–60) were ineffective. These data identify the COOH terminus of FGF-2 as a putative ganglioside-binding region. Exogenous gangliosides inhibit the binding of 125I-FGF-2 to high-affinity tyrosine-kinase FGF-receptors (FGFRs) of endothelial GM 7373 cells at micromolar concentrations. The order of relative potency was GT1b ? GD1b ? GM1 ? sulfatide a ? sialo-GM1. Accordingly, GT1b,GD1b, GM1, and GM2, but not GM3 and

Marco Rusnati; Elena Tanghetti; Chiara Urbinati; Giovanni Tulipano; Sergio Marchesini; Marina Ziche; Marco Presta
1999-01-01

375

The role of placental alkaline phosphatase in the regulation of insulin-like growth factor binding protein-1 in pregnancy complicated by diabetes.

  Open Access Theses and Dissertations

Summary: ??Introduction: Abnormal fetal growth remains a major problem in pregnancies complicated by diabetes and is associated with increased maternal and offspring mortality and morbidity. Insulin-like… (more)

Lubina Solomon, Alexandra
2011-01-01

376

Insulin-Like Growth Factor Binding Proteins -1 and -3, and Hydroxysteroid (11-Beta) Dehydrogenase One: Potential Roles in Ruminant Conceptus Development and Endometrial Function.

  Open Access Theses and Dissertations

Summary: ??Maternal contributions from the uterine endometrial luminal (LE) and glandular (GE) epithelia are unequivocally required to support ruminant conceptus growth and development, elongation and implantation.… (more)

Simmons, Rebecca M.
2010-01-01

377

Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF.

  Open Access Theses and Dissertations

Summary: ??Biocompatible hydrogels composed of covalently crosslinked, chemically modified hyaluronan (HA), gelatin (Gtn), and heparin (Hp) were synthesized for controlled release of human vascular endothelial growth… (more)

Pike, Daniel B.
2007-01-01

378

Molecular beam epitaxy growth and characterization of type-II InAs/GaSb strained layer superlattices for long-wave infrared detection

  Materials Science Websites

Summary: superlattices for long-wave infrared detection E. Plis,a A. Khoshakhlagh, S. Myers, H. S. Kim, N. Gautam, Y. DAs/GaSb and InAs/InxGa1-xSb strained layer superlattices SLSs for long-wave infrared detection. Growth conditions in excessive dark current due to tunneling.1 Since first proposed in the 1980s Refs. 2 and 3 InAs/ InGa Sb

New Mexico, University of

379

Insulin-Like Growth Factor Binding Proteins -1 and -3, and Hydroxysteroid (11-Beta) Dehydrogenase One: Potential Roles in Ruminant Conceptus Development and Endometrial Function

  Texas A&M University - TxSpace

Summary: Maternal contributions from the uterine endometrial luminal (LE) and glandular (GE) epithelia are unequivocally required to support ruminant conceptus growth and development, elongation and implantation. Therefore, studies were conducted to examine...

Simmons, Rebecca M.
2010-07-14

380

Multiwavelength study of massive galaxies at z~2. II. Widespread Compton thick AGN and the concurrent growth of black holes and bulges

  Astrophysics (arXiv)

Summary: Approximately 20-30% of 1.46.2 keV. The stacked X-ray spectrum rises steeply at >10 keV, suggesting that these sources host Compton-thick Active Galactic Nuclei (AGNs) with column densities N_H~10^{24} cm^-2 and an average, unobscured X-ray luminosity L_{2-8 keV}~(1-4)x10^43 erg/s. Their sky density(~3200 deg^-2) and space density (~2.6x10^-4 Mpc^-3) are twice those of X-ray detected AGNs at z~2, and much larger than those of previously-known Compton thick sources at similar redshifts. The mid-IR excess galaxies are part of the long sought-after population of distant heavily obscured AGNs predicted by synthesis models of the X-ray background. The fraction of mid-IR excess objects increases with galaxy mass, reaching ~50-60% for M~10^11 M_sun, an effect likely connected with downsizing in galaxy formation. The ratio of theinferred black hole growth rate from these Compton-thick sources to the global star formation rate at z=2 is similar to the mass ratio of black holes to stars inlocal spheroids, implying concurrent growth of both within the precursors oftoday's massive galaxies.

E. Daddi; D. M. Alexander; M. Dickinson; R. Gilli; A. Renzini; D. Elbaz; A. Cimatti; R. Chary; D. Frayer; F. E. Bauer; W. N. Brandt; M. Giavalisco; N. A. Grogin; M. Huynh; J. Kurk; M. Mignoli; G. Morrison; A. Pope; S. Ravindranath
2007-05-19

381

Laplacian Growth II: Saffman - Taylor Problem Without Surface Tension in Filtration Combustion: Formation of One Finger with Half of the Channel Width

  Nonlinear Sciences (arXiv)

Summary: Filtration combustion is described by Laplacian growth without surface tension. These equations have elegant analytical solutions that replace the complex integro-differential motion equations by simple differential equations of pole motion in a complex plane. The main problem with such a solution is the existence of finite time singularities. To prevent such singularities, nonzero surface tension is usually used.However, nonzero surface tension does not exist in filtration combustion, and this destroys the analytical solutions. However, a more elegant approach exists for solving the problem. First, we can introduce a small amount of pole noise to the system. Second, for regularisation of the problem, we throw out all new poles that can produce a finite time singularity. It can be strictly proved that the asymptotic solution for such a system is a single finger. Moreover, the qualitative consideration demonstrates that a finger with 1/2 of the channel width is statistically stable. Therefore, all properties of such a solution are exactly the same as those of the solution with nonzero surface tension under numerical noise. The solution of the ST problem without surface tension is similar to the solution for the equation of cellular flames in the case of the combustion of gas mixtures.

Oleg Kupervasser
2014-05-22

382

Form factors in the massless coset models su(2)_k+1 \\otimes su(2)_k /su(2)_2k+1 - Part II

  Mathematical Physics (arXiv)

Summary: Massless flows from the coset model su(2)_k+1 \\otimes su(2)_k /su(2)_2k+1 to the minimal model M_k+2 are studied from the viewpoint of form factors. These flows include in particular the flow from the Tricritical Ising model to the Ising model. By analogy with the magnetization operator in the flow TIM -> IM, we construct all form factors of an operator that flows to \\Phi_1,2 in the IR. We make a numerical estimation of the difference of conformal weights between the UV and the IR thanks to the \\Delta-sum rule; the results are consistent with the conformal weight of the operator \\Phi_2,2 in the UV. By analogy with the energy operator in the flow TIM -> IM, we construct all form factors of an operator that flows to \\Phi_2,1. We propose to identify the operator in the UV with \\sigma_1\\Phi_1,2.

P. Grinza; B. Ponsot
2005-04-11

383

Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation by a platelet-derived growth factor receptor

  Biology and Medicine Websites

Summary: Bone-metastatic potential of human prostate cancer cells correlates with Akt/PKB activation of Pathology, Drexel University College of Medicine, Philadelphia, PA 19102, USA Prostate adenocarcinoma be the ability of bone- produced factors to specifically select disseminated prostate cancer cells

Meucci, Olimpia

384

Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFβ-Activated Kinase 1 Tyrosine Phosphorylation and NFκB Signaling in Multiple Myeloma and Bladder Cancer

  University of California eScholarship Repository

Summary: factor-beta-activated kinase-1 blocks cancer cell adhesion,beta}1 through MAPK/ERK kinase pathway. Am J Physiol Lung Cellbeta-1,4-N-acetylglucosaminyltransferase, isozyme A NM_012214 1.11E-04 Down A microarray experiment was performed using MGHU3 bladder cancer cells


2014-01-01

385

Measurement of Lande g factor of 5D5/2 state of BaII with a single trapped ion

  CERN Preprints

Summary: We present the first terrestrial measurement of the Lande g factor of the 5D5/2 state of singly ionized barium. Measurements were performed on single Doppler-cooled 138Ba+ ions in a linear Paul trap. A frequency-stabilized fiber laser with nominal wavelength 1.762 um was scanned across the 6S1/25D5/2 transition to spectroscopically resolve transitions between Zeeman sublevels of the ground and excited states. From the relative positions of the four narrow transitions observed at several different values for the applied magnetic field, we find a value of 1.2020+/-0.000 for g of 5D5/2.

Kurz, N; Shu, Gang; Noel, T; Blinov, B B
2010-01-01

386

On the von Neumann Economic Growth Problem Yinyu YE \\Lambda

  Computer Technologies and Information Sciences Websites

Summary: of inputs consumed, during one time period. Then, fl represents the growth factor at intensity y. So By â?? fl required in period (t + 1) with the growth factor fl. The NEG problem is to find the largest growth factorOn the von Neumann Economic Growth Problem Yinyu YE \\Lambda Department of Management Sciences

Ye, Yinyu

387

Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J Neurosci 2002;22:8922–31

  CiteSeer

Summary: Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates the adaptive response to hypoxia in mammalian cells. It consists of a regulatory subunit HIF-1?, which accumulates under hypoxic conditions, and a constitutively expressed subunit HIF-1?. In this study we analyzed HIF-1 ? expression in the rat cerebral cortex after transient global ischemia induced by cardiac arrest and resuscitation. Our results showed that HIF-1 ? accumulates as early as 1 hr of recovery and persists for at least 7 d. In addition, the expression of HIF-1 target genes, erythropoietin and Glut-1, were induced at 12 hr to 7d of recovery. A logical explanation for HIF-1 ? accumulation might be that the brain remained hypoxic for prolonged periods after resuscitation. By using the hypoxic marker 2-(2-nitroimidazole-1[H]-y1)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5), we showed

Juan C. Chavez; Joseph C. Lamanna

388

A Structural Analysis of Chile's Long-Term Growth: History, Prospects and Policy Implications*

  Renewable Energy Websites

Summary: II.1 Climate Zone II.2 Scope of the Market II.3 Natural Resource Endowments II.4 Population, Culture of these Structural Features III. Chile's Long-Term Growth Record in International Comparison IV. Natural Resource and the Volatility of Export Earnings IV.4 Are Natural Resources a Hindrance to Growth? IV.5 A Brief Literature


389

Original article Decreased circulating growth hormone levels

  Physics Websites

Summary: insulin-like growth factor-1 is not mediated by somatostatin in the pig fetus GSG Spencer AA Macdonald SS of the levels of insulin-like growth factor 1 (IGF-1which are lower in the pig fetus (Spencer et al, 1983a, 1989Original article Decreased circulating growth hormone levels following centrally administered

Paris-Sud XI, Université de

390

Quasar Spectrum Classification with PCA - II: Introduction of Five Classes, Artificial Quasar Spectrum, the Mean Flux Correction Factor dF,and the Identification of Emission Lines in the Ly alpha Forest

  Astrophysics (arXiv)

Summary: We investigate the variety in quasar UV spectra (1020-1600A) with emphasis on the weak emission lines in the Ly alpha forest region using principal component analysis (PCA). This paper is a continuation of Suzuki et al. (2005, Paper I), but with a different approach. We use 50 smooth continuum fitted quasar spectra (0.14 < z < 1.04) taken by the Hubble Space Telescope (HST) Faint Object Spectrograph. Three weak emission lines in the Ly alpha forest are identified as FeII 1070.95A, FeII+FeIII 1123.17A, and CIII* 1175.88A. Using first two standardized PCS coefficients, we introduce five classifications: Class Zero and Class I-IV. These classifications will guide us in finding the continuum level in the Ly alpha forest, and we discuss the characteristics of each class. We show weak emission lines in the Ly alpha forest become eminent for Class III and IV. By actively using PCS, we can generate artificial quasar spectra which are useful to test the detection of quasars, DLAs, and the continuum calibration. We provide 10,000 artificially generated spectra. We show that the power-law extrapolated continuum is inadequate to perform precise measurements of the mean flux in the Ly alpha forest because of the weak emission lines and the extended tails of Ly alpha and Ly beta/OVI emission lines. We introduce a correction factor dF such that the true mean flux can be related to that is measured by using power-law continuum extrapolation: = dF. The correction factor dF ranges from 0.84 to 1.05 with a mean of 0.947 and a standard deviation of 0.031 for our 50 quasars. This result means that we miss 5.3% of flux on average and we show that there are cases where we would miss 16% of flux using a power-law extrapolation.

Nao Suzuki
2005-03-10

391

Stability of block LDLT factorization of a

  Mathematics Websites

Summary: birthday Abstract For symmetric inde®nite tridiagonal matrices, block LDLT factorization without in factorization; Growth factor; Numerical stability; Rounding error analysis; LAPACK; LINPACK 1. Introduction and explain how Bunch's derivation of it yields a bound of order 1 for the growth factor. In Section 3 we show

Higham, Nicholas J.

392

Printed in U.S.A. Copyright © 1997 by The Endocrine Society Involvement of Glucocorticoid-Induced Factor(s) in the Stimulation of Growth Hormone Expression in the Fetal Rat Pituitary Gland in Vitro*

  CiteSeer

Summary: The mechanism by which glucocorticoids induce GH expression between embryonic days 18 and 19 (E18–19) in the fetal rat pituitary gland was examined with an in vitro organ culture system. Twentyfour hour incubation of E18 pituitary glands in serum-free medium containing either dexamethasone (DEX, 5–50 nM) or corticosterone (0.5–5 ?M) resulted in a conspicuous accumulation of GH messenger RNA (mRNA), whereas no spontaneous expression of GH mRNA was noted without glucocorticoid. Triiodothyronine (1 nM) alone weakly induced GH mRNA but increased the effect of DEX 2-fold. The GH mRNA accumulation was not observed after 5 or 10 h incubation with THE DIFFERENTIATION and development of GH cells in the fetal rat pituitary gland depend largely upon functions of the pituitary specific nuclear transcription factor pit-1 (also known as GHF-1). Several studies have established

Haruo Nogami; Kinji Inoue; Koki Kawamura

393

GROUP ACTIONS ON INJECTIVE FACTORS

  Mathematics Websites

Summary: GROUP ACTIONS ON INJECTIVE FACTORS Yasuyuki Kawahigashi Department of Mathematics, Faculty in classification of group actions on injective factors. We deal with three kinds of groups; discrete groups, actions on the injective factor of type II1 are considered, and for the last one, we give a complete

Kawahigashi, Yasuyuki

394

Effectiveness of Learning Transportation Network Growth through the Use of Simulator

  Engineering Websites

Summary: 0 Effectiveness of Learning Transportation Network Growth through the Use of Simulator May 19, 2004....................................................................................................3 II. SIMULATION AND SIMULATOR OF NETWORK GROWTH (SONG 1...................................................................................5 B. SIMULATOR OF NETWORK GROWTH (SONG 1.0)...................................................9 III

Levinson, David M.

395

: (i) -, ; (ii) -

  Biology and Medicine Websites

Summary: . . () , . , . , . ­ ­ , . : , , , . , , , , , , . . , , , «» : (i) - , ; (ii) - , (van Doorn et al., 2011). 30- , . , . , , , . , (Galluzzi et al., 2012). , (van Doorn et al., 2011.) , ( , ) , . , , - (Bonneau et al., 2008), , , , ­ (Uren et al., 2000). , , , , . : (VPE

Kaplan, Alexander

396

Water ice growth around evolved stars

  Astrophysics (arXiv)

Summary: We present a model of the growth of water ice on silicate grains in the circumstellar envelopes of Asymptotic Giant Branch (AGB) stars and Red Super Giants. We consider the growth of ice by gas grain collisions, the thermal evaporation of ice from a grain, and sputtering. Our model contains several improvements compared to earlier models, including a detailed treatment of the effects of sputtering, a detailed calculation of the radiation pressure on the grain, and the treatment of subsonic drift velocities. In terms of drift velocity between the grains and gas in the envelope, we find that the ice formation process can be divided into three regimes: (i) a sputtering dominated regime where ice growth is heavily suppressed, (ii) an intermediate regime with moderately efficient condensation and (iii) a thermally dominated regime where ice formation is highly efficient. Sputtering is the critical factor which determines if ice formation can occur at all. We find that in Red Supergiants, ice formation is suppressed, while the winds of OH/IR stars allow for efficient condensation and can convert significant fractions of the available water vapor (tens of percent) into ice mantles on grains. Population II AGB stars hardly form ice due to their low dust to gas ratios. We also modify an analytical equation describing condensation and depletion (Jura and Morris, 1985) in order to give reasonable results for high and low drift velocities. Initially, ice will condense in crystalline form, but continuing condensation at low temperatures, and damage caused by interstellar UV photons favor the production of amorphous ice as well. We predict that a significant fraction of the ice formed will be amorphous.

C. Dijkstra; C. Dominik; S. N. Hoogzaad; A. de Koter; M. Min
2003-01-29

397

Singular subfactors of II_1 factors

  Texas A&M University - TxSpace

Summary: off of other people’s chairs at Glasgow. Thanks to Thomas Schlumprecht for making my transition here so easy and to Ken Dykema, Gilles Pisier, and Bill Johnson for putting up with my stupid questions. Being in the math department at A&M made me realize... for honestly describing what to expect as a researcher. I thank all my friends from UT, especially Kate, Adam, Judy, Cecilia, Kurt, Chris, Christine, Kelly, Rafael, and Mike. ”I was so afraid that you would all be math nerds!” Yeah, me, too! What the hell...

Wiggins, Alan Daniel
2007-09-17

398

Learning II Factors that influence CC

  Multidisciplinary Databases and Resources Websites

Summary: rarely encounter the exact same stimulus twice Discrimination CS+ ---> UCS CS- ---> ____ · The stimuli will come to control responding: ­ The CS+ will elicit a CR ­ The CS- will not elicit a CR Discrimination 0

Coulson, Seana

399

II. The Community Organizes........................................................................................................4

  CiteSeer

Summary: Acknowledgements......................................................................................................................... ii Executive Summary....................................................................................................................... iii

Starflower Foundation; Ella Elman; Ecologist Contents

400

II. The Community Organizes............................................................................................5

  CiteSeer

Summary: Acknowledgements............................................................................................................. ii Executive Summary........................................................................................................... iii

Starflower Foundation; Ella Elman; Ecologist Contents

401

II. The Community Organizes........................................................................................................3

  CiteSeer

Summary: Acknowledgements......................................................................................................................... ii Executive Summary....................................................................................................................... iii

Starflower Foundation; Ella Elman; Ecologist Contents

402

Binghamton University Graduate Growth Initiative

  Materials Science Websites

Summary: academic programs and departments an opportunity to develop new tracks within degrees, new graduate certificates and new degree initiatives that can foster new avenues of intellectual pursuit and career be expanded to meet the growth initiatives; (ii) serve as a general call for proposals for new career

Suzuki, Masatsugu

403

I. The Growth Plate A. Structural organization

  CiteSeer

Summary: The growth plate is the final target organ for longitudinal growth and results from chondrocyte proliferation and differentiation. During the first year of life, longitudinal growth rates are high, followed by a decade of modest longitudinal growth. The age at onset of puberty and the growth rate during the pubertal growth spurt (which occurs under the influence of estrogens and GH) contribute to sex difference in final height between boys and girls. At the end of puberty, growth plates fuse, thereby ceasing longitudinal growth. It has been recognized that receptors for many hormones such as estrogen, GH, and glucocorticoids are present in or on growth plate chondrocytes, suggesting that these hormones may influence processes in the growth plate directly. Moreover, many growth factors, i.e., IGF-I, Indian hedgehog, PTHrP, fibroblast growth factors, bone morphogenetic proteins, and vascular endothelial growth factor, are now considered as crucial regulators of chondrocyte proliferation and differentiation. In this review, we present an update on the present perception of growth plate function and the regulation of chondrocyte proliferation and differentiation by systemic and local regulators of which most are now related to human growth

M. Karperien; J. M. Wit; B. Extracellular Matrix Proteins; B. Thyroid Hormone; C. Glucocorticoids; D. Estrogens; E. Androgens; F. Intracrinology

404

Revisited abundance diagnostics in quasars: Fe II/Mg II ratios

  Astrophysics (arXiv)

Summary: Both the Fe II UV emission in the 2000- 3000 A region [Fe II (UV)] and resonance emission line complex of Mg II at 2800 A are prominent features in quasar spectra. The observed Fe II UV/ Mg II emission ratios have been proposed as means to measure the buildup of the Fe abundance relative to that of the alpha-elements C, N, O, Ne and Mg as a function of redshift. The current observed ratios show large scatter and no obvious dependence on redshift. Thus, it remains unresolved whether a dependence on redshift exists and whether the observed Fe II UV/ Mg II ratios represent a real nucleosynthesis diagnostic. We have used our new 830-level model atom for Fe+ in photoionization calculations, reproducing the physical conditions in the broad line regions of quasars. This modeling reveals that interpretations of high values of Fe II UV/ Mg II are sensitive not only to Fe and Mg abundance, but also to other factors such as microturbulence, density, and properties of the radiation field. We find that the Fe II UV/ Mg II ratio combined with Fe II (UV)/ Fe II (Optical) emission ratio, where Fe II (Optical) denotes Fe II emission in 4000 - 6000 A can be used as a reliable nucleosynthesis diagnostic for the Fe/Mg abundance ratios for the physical conditions relevant to the broad-line regions (BLRs) of quasars. This has extreme importance for quasar observations with the Hubble Space Telescope and also with the future James Webb Space Telescope.

E. Verner; F. Bruhweiler; D. Verner; S. Johansson; T. Gull
2003-06-25

405

Research Report Laminin activates CaMK-II to stabilize nascent

  Biology and Medicine Websites

Summary: enriched along the axon and in the growth cone as detected using a phospho-Thr287 specific CaMK-II antibody. 1 integrin was found in a similar pattern along the axon and in the growth cone. Direct inhibition of CaMK-II in 1-day-old neurons immediately froze growth cone dynamics, disorganized F

Tombes, Robert M.

406

Hepatocyte Growth Factor By Alex Brown

  Environmental Sciences and Ecology Websites

Summary: phospholipase c- (PLC-), phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K), Ras G protein, and STAT (a). It also provides sites for PI3K, Shp2, STAT and Crk to associate (Gual et al, 2000). Hence the binding

Nottingham, University of

407

517.95:517.958:517.928(06) ii ii i ii: . .

  Mathematics Websites

Summary: ii ii i ii #12; .. I i i , i I i i 19 I : i ii ii i ii I · 1998 #12; 517.95:517.958:517.928(06) ii ii i ii: . . . / . I- ; .: .. iii i. ­ , 1998. ­ 280 . i i i i- i i ii. i i - 'i ii ii i i ­ i ii, i, , i, , -i i. i i i i ­ i - i . i , i i i. ii, ii, i i - i i

Popovych, Roman

408

LES ENNEMIS DES BOURDONS II. —

  Physics Websites

Summary: .R.A., 91440 Bures-sur-Yvette SUMMARY THE ENEMIES OF BUMBLE-BEES. II. - ORGANISMS AFFECTING ADULTS The author investigates the relations between bumble-bees and their enemies, predators and parasites, when the connections, particularly poisonings due to insecticides, add themselves to biotic factors of natural limitation of bumble

Paris-Sud XI, Université de

409

Factoring Factor Maps

  CiteSeer

Summary: . A noninjective bounded-to-one factor map from an irreducible shift of finite type onto a sofic system can be factored as a composition of other such maps in only finitely many ways (up to isomorphism). This generalizes to factor maps from systems with canonical coordinates to finitely presented dynamical systems. Section 0. Introduction The analysis of bounded-to-one and especially of resolving factor maps has played a key role in the study of various coding relations among shifts of finite type and Markov chains [2, 3, 7, 14, 20 ... ]. The classification of sofic systems up to topological conjugacy reduces to the classification of such maps, because sofic systems come with canonical resolving factor maps from shifts of finite type [15, 5]. The study of these maps is also at the heart of applications of symbolic dynamical ideas to the problem of efficiently coding data into and out of magnetic media [1, 12, 17]. The problem of determining when there exists a resolving map between tw...

Mike Boyle
1998-01-01

410

for SME Growth Evidence from India

  CiteSeer

Summary: This paper probes the drivers, dimensions, achievements, and outcomes of technological innovations carried out by SMEs in the auto components, electronics, and machine tool sectors of Bangalore in India. Further, it ascertains the growth rates of innovative SMEs vis-à-vis noninnovative SMEs in terms of sales turnover, employment, and investment. Thereafter, it probes the relationship between innovation and growth of SMEs by (i) estimating a correlation between innovation sales and sales growth, (ii) calculating innovation sales for high, medium, and low growth innovative SMEs and doing a one-way ANOVA, and (iii) ascertaining the influence of innovation sales, along with investment growth and employment growth on gross value-added growth by means of multiple regression analysis. The paper brings out substantial evidence to argue that innovations of SMEs contributed to their growth.

M. H. Bala Subrahmanya; M. Mathirajan; K. N. Krishnaswamy; M. H. Bala Subrahmanya; M. Mathirajan; K. N. Krishnaswamy
2010-01-01

411

HUMAN FACTORS IN COMPUTING SYSTEMS

  Computer Technologies and Information Sciences Websites

Summary: HUMAN FACTORS IN COMPUTING SYSTEMS CHI '95 CONFERENCE COMPANION iiANOW14:118 "ML". ft .AIR. an as CHI `95MOSAIC OF CREATIVITY C O N F E R E N C E O N HUMAN FACTORS IN COMPUTING SYSTEMS MAY 7-11 1995 " CHI `95 MOSAIC OF CREATIV Visual annotation of links in adaptive hypermedia Peter Brusilovsky On leave

Brusilovsky, Peter

412

Macrophage Integrin-Mediated, HuR-Dependent Angiogenic Factor Gene Expression.

  Open Access Theses and Dissertations

Summary: ??Activated macrophages, via the secretion of pro-angiogenic factors, modulate the angiogenic response to inflammation. Several of these factors, including vascular endothelial growth factor (VEGF), are… (more)

Modi, Yasha Satish

413

Introduction of Economic Growth

  CiteSeer

Summary: If the time since modern humans first appeared, some 200 thousand years ago, were magically compressed into a single day, the era of sustained growth in living standards would occupy only the most recent minute and a half. Prior to this emergence (around 1800), living standards were low and did not vary enormously throughout the world—perhaps by a factor of 2 according to numbers compiled by the late economist Angus Maddison ( 1). The emergence of modern economic growth in some parts of the world but not others has caused living standards to diverge dramatically. By the end of the 20th century, the ratio of per capita gross domestic product (GDP) in the richest countries exceeded that in the poorest by more than a factor of 50.

Charles I. Jones; Michael Spence Takes; Michael Spence
1998-01-01

414

DO LEADERS MATTER? NATIONAL LEADERSHIP AND GROWTH SINCE WORLD

  Computer Technologies and Information Sciences Websites

Summary: rates. We find robust evidence that leaders matter for growth. The results suggest that the effectsDO LEADERS MATTER? NATIONAL LEADERSHIP AND GROWTH SINCE WORLD WAR II* BENJAMIN F. JONES AND BENJAMIN A. OLKEN February 2005 ABSTRACT Economic growth within countries varies sharply across decades

Bustamante, Fabián E.

415

Vitamin B12, antibiotics and unidentified factors in the nutrition of the turkey poult and mature chicken

  Texas A&M University - TxSpace

Summary: that liver "L" and dried whey contained at least on unidenti- fied factor, not Identical with vitamin B19, which was required for rapid chick growth. Stokstad et al. ('49) also reported that the "animal protein factor" consisted of vitamin B19 plus some... effort in typing this thesis. 00'ii TEA i S Introduction 1&eview of the Li terature Experimental Procedure Hesults and Discussion 11 . 20 Summary Li terature Gi ted Tables 32 40 I NT RODU0TI 0 N /Zhe importance of animal protein 1n poultry...

Reid, Bobby Leroy
2012-06-07

416

Economic Growth

  CiteSeer

Summary: We analyze an economy that lacks a strong legal-political institutional infrastructure and is populated by multiple powe*rful groups. Powerful groups dynamically interact via a,$scal process that effectively allows open access to the aggregate capital stock. In equzl~&ium, this leads to slow economic growth and a “‘voracity e,@ect, ” by which a shock, such as a terms o,f trade wind-,fall, perversely generates a more than proportionate increase in fiscal redistribution and reduces growth. We also show that a dilution in the concentration o,f power leads to,faster growth and a less procyclical response to shocks. (JEL F43, 010, 023, 040) Two common characteristics of developing countries that have grown slowly in the last several decades are the absence of strong legal and political institutions and the presence of multiple powerful groups in society. In this paper, we analyze a dynamic model of the economic growth process that contains these features. We employ the model to ask three questions. First, why does the combination of a weak institutional structure and fractionalization inside the governing elite generate slow growth? Second, what is the relationship between the concentration of power (the number of powerful groups) and growth? Third, why do such countries not only grow slowly but also frequently respond in a perverse fashion to favorable shocks, by increasing more than proportionally fiscal redistribution and investing in inefficient capital projects?

Philip R. Lane; Aaron Tornell; Philip R. Lane; Aaron Tornell
1976-01-01

417

General law of growth and replication. Growth equation and its applications

  CERN Preprints

Summary: We present significantly advanced studies of the previously introduced physical growth mechanism and unite it with biochemical growth factors. Obtained results allowed formulating the general growth law which governs growth and evolutional development of all living organisms, their organs and systems. It was discovered that the growth cycle is predefined by the distribution of nutritional resources between maintenance needs and biomass production. This distribution is quantitatively defined by the growth ratio parameter, which depends on the geometry of an organism, phase of growth and, indirectly, organism's biochemical machinery. The amount of produced biomass, in turn, defines the composition of biochemical reactions. Changing amount of nutrients diverted to biomass production is what forces organisms to proceed through the whole growth and replication cycle. The growth law can be formulated as follows: the rate of growth is proportional to influx of nutrients and growth ratio. Considering specific biochem...

Shestopaloff, Yu K
2012-01-01

418

The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin and the comparison of this procedure with other tests of pituitary and adrenal function. II. In patients with hypothalamic or pituitary dysfunction or anorexia nervosa

  CiteSeer

Summary: The sequence of events that follows the intravenous injection of insulin has been reviewed extensively by De Bodo and Altszuler (1). A complex set of mechanisms normally operates to antagonize the action of insulin, thereby limiting the extent to which the blood glucose falls and causing a rapid return to original levels. There is evidence that glucocorticoids and growth hormone play an important role as hormonal insulin antagonists. Thus both Addison's disease and hypopituitarism are known to be associated with increased insulin sensitivity, whereas patients with Cushing's syndrome or acromegaly are resistant to its hypoglycemic action (2, 3). The observation that the intravenous injection of insulin into control subjects results in rapid elevations of plasma cortisol (4, 5) and growth hormone (6-9) also supports the possible physiologic importance of these hormones as insulin antagonists. Since the release of these two hormones depends on adequate hypothalamic as well as pituitary and adrenal function (5, 7, 10), it was apparent that a rapid test of both the hypothalamo-pituitary-adrenal axis for the secretion of cortisol and the hypothalamo-pituitary axis for the secretion of growth hormone could be developed with insulininduced hypoglycemia as a stimulus. The present paper describes the time sequence of the changes in plasma sugar, free fatty acids (FFA), cortisol, and growth hormone in normal * Submitted for publication September 21, 1965; accepted

F. C. Greenwood; T J. Landon; T. C. B. Stamp
1966-01-01

419

Pattern formation in crystal growth under parabolic shear flow. II Research Institute for Applied Mechanics, Kyushu University, 6-1 Kasuga-koen, Kasuga, Fukuoka 816-8580, Japan

  Physics Websites

Summary: the surface of icicles or inclined plane. In a previous paper [K. Ueno, Phys. Rev. E 68, 021603 (2003)], we be experimentally produced during ice growth by continu- ously supplying a proper water Q ml/h on an inclined plane with mean velocity V¯ from an undercooled thin liquid flowing down an inclined plane under the action

Goldstein, Raymond E.

420

Genetic Inactivation of ERK1 and ERK2 in Chondrocytes Promotes Bone Growth and Enlarges the Spinal Canal

  Biotechnology Websites

Summary: in achondroplasia. Conversely, whether the decrease--or inactivation--of ERK1 and ERK2 promotes bone growth is activated by various cytokines and growth factors, including family members of fibroblast growth factor (FGF


421

Introduction Factorization

  Mathematics Websites

Summary: A Friendly Introduction to Factorization Theory Chapman Introduction The Language of Factorization Theory Factorization in Hilbert's Monoid Factorization in Meyerson's Monoid A Tale of Two Sequences: A Friendly Introduction to the Theory of Non-Unique Factorization in Integral Domains and Monoids Scott

Chapman, Scott

422

GaN growth by RF-plasma assisted molecular beam epitaxy.

  Open Access Theses and Dissertations

Summary: ??Growth of GaN by molecular beam epitaxy is ultimately limited by thermal decomposition. Factors influencing thermal decomposition are growth species (atomic versus metastable molecular nitrogen),… (more)

VanMil, Brenda.
2005-01-01

423

II. METHODOLOGY

  CiteSeer

Summary: Abstract—The main objective of this project is to build an autonomous microcontroller-based mobile robot for a local robot soccer competition. The black competition field is equipped with white lines to serve as the guidance path for competing robots. Two prototypes of soccer robot embedded with the Basic Stamp II microcontroller have been developed. Two servo motors are used as the drive train for the first prototype whereas the second prototype uses two DC motors as its drive train. To sense the lines, lightdependent resistors (LDRs) supply the analog inputs for the microcontroller. The performances of both prototypes are evaluated. The DC motor-driven robot has produced better trajectory control over the one using servo motors and has brought the team into the final round.

A. A. Shafie; M. F. Alias; M. H. Ali; Line Following

424

ISSN 13601725 Stability of Block LDL T Factorization of a

  Mathematics Websites

Summary: Abstract For symmetric indefinite tridiagonal matrices, block LDL T factorization without interchanges­ ing method, LDL T factorization, growth factor, numerical stability, rounding error analysis, LAPACK a bound of order 1 for the growth factor. In Section 3 we show that kLk=kAk can be arbitrarily large

Higham, Nicholas J.

425

Growth Kinetics of Wildlife E. coli Isolates in Soil and Water

  Texas A&M University - TxSpace

Summary: ................................................................................................... viii LIST OF TABLES .................................................................................................... x CHAPTER I INTRODUCTION ................................................................................ 1 1.1.... Introduction ................................................................................... 1 1.2. Objectives ..................................................................................... 6 II GROWTH KINETICS OF E. coli ISOLATES...

Gallagher, Meghan
2012-07-16

426

Metabolic indices for growth: endocrine profile of steers on different nutritional and growth regulation regimes

  Texas A&M University - TxSpace

Summary: . . Body composition determination. Physiological measurements. Analysis and interpretation RESULTS AND DISCUSSION. . Treatment effects on endocrine factors and metabolites. . . . . . 10 . . . . . . . 1 3 . . . . . . . 1 3 . 16 . . . . 18 . 20... . . . . 22 . . . . . 22 Intake level effects on endocrine factors and metabolites. . . . . . . . . 32 Treatment effects on growth functions. . Intake level effects on growth functions. . . . . . . 40 . . . . 43 RESULTS AND DISCUSSION (cont...

Reinhardt, Christopher Dean
1991-01-01

427

Lemniscate growth

  Hopf Topology Archive

Summary: May 8, 2012 ... It was recently noticed that lemniscates do not survive Laplacian growth [12] ...... are complex analytic, the equation is valid not only on ? but everywhere the ... fluid is called “shear-thickening” (e.g., corn-starch and water).


2012-05-08

428

Improved parametrization of the growth index for dark energy and DGP models

  General Relativity & Quantum Cosmology (arXiv)

Summary: We propose two improved parameterized form for the growth index of the linear matter perturbations: (I) $\\gamma(z)=\\gamma_0+(\\gamma_{\\infty}-\\gamma_0){z\\over z+1}$ and (II) $\\gamma(z)=\\gamma_0+\\gamma_1 \\frac{z}{z+1}+(\\gamma_{\\infty}-\\gamma_1-\\gamma_0)(\\frac{z}{z+1})^{\\alpha}$. With these forms of $\\gamma(z)$, we analyze the accuracy of the approximation the growth factor $f$ by $\\Omega^{\\gamma(z)}_m$ for both the $\\omega$CDM model and the DGP model. For the first improved parameterized form, we find that the approximation accuracy is enhanced at the high redshifts for both kinds of models, but it is not at the low redshifts. For the second improved parameterized form, it is found that $\\Omega^{\\gamma(z)}_m$ approximates the growth factor $f$ very well for all redshifts. For chosen $\\alpha$, the relative error is below 0.003% for the $\\Lambda$CDM model and 0.028% for the DGP model when $\\Omega_{m}=0.27$. Thus, the second improved parameterized form of $\\gamma(z)$ should be useful for the high precision constraint on the growth index of different models with the observational data. Moreover, we also show that $\\alpha$ depends on the equation of state $\\omega$ and the fractional energy density of matter $\\Omega_{m0}$, which may help us learn more information about dark energy and DGP models.

Jiliang Jing; Songbai Chen
2009-08-30

429

Revisited abundance diagnostics in quasars: Fe II/Mg II ratios

  CERN Preprints

Summary: Both the Fe II UV emission in the 2000- 3000 A region [Fe II (UV)] and resonance emission line complex of Mg II at 2800 A are prominent features in quasar spectra. The observed Fe II UV/ Mg II emission ratios have been proposed as means to measure the buildup of the Fe abundance relative to that of the alpha-elements C, N, O, Ne and Mg as a function of redshift. The current observed ratios show large scatter and no obvious dependence on redshift. Thus, it remains unresolved whether a dependence on redshift exists and whether the observed Fe II UV/ Mg II ratios represent a real nucleosynthesis diagnostic. We have used our new 830-level model atom for Fe+ in photoionization calculations, reproducing the physical conditions in the broad line regions of quasars. This modeling reveals that interpretations of high values of Fe II UV/ Mg II are sensitive not only to Fe and Mg abundance, but also to other factors such as microturbulence, density, and properties of the radiation field. We find that the Fe II UV/ Mg II...

Verner, E M; Verner, D A; Johansson, S; Gull, T R
2003-01-01

430

Mouse Snail family transcription repressors regulate chondrocyte extracellular matrix, type II collagen and aggrecan

  Physics Websites

Summary: differentiation Key Words: Snail, transcription factor, chondrocyte, collagen type II, aggrecan 1 Endocrine Unit (3-7). Type II collagen is a homotrimer of the alpha1 (II) chain (Col2a1). Two elements1 Mouse Snail family transcription repressors regulate chondrocyte extracellular matrix, type II

Paris-Sud XI, Université de

431

Public Networks and Economic Growth

  CiteSeer

Summary: Abstract: This paper discusses the role of public networks in economic growth and development. Disclaimer: The opinions presented herein are held by the author and are not necessarily those of Yahoo! Inc. Perhaps the most fundamental question of economics is: “What leads to economic growth?” Sustained growth can make a huge difference in things that matter – infant mortality, education, quality of life – within a single generation. Moreover, it is clear that policies matter: at the end of World War II, North Korea was the richer, relatively well-developed portion of the Korean peninsula, whereas today South Korea is over fifteen times richer per person. Governments have played a substantial role in growth, with contributions that are both positive and negative. While some economists argue that government only harms growth, the empirical evidence doesn’t corroborate this position. Moreover, there are sound theoretical reasons for government involvement in coordination and public goods. Most of the empirical literature is consistent with a finding that government involvement in transportation and communication enhances economic growth. This note government explores involvement in, either through regulating, subsidizing or operating, public networks. Economics has recently developed new tools for operating public networks and exchanges, which can be brought to bear on this

R. Preston Mcafee
2009-01-01

432

ii i i , i i i i ii I

  Mathematics Websites

Summary: ii i i , i i i i ii I I 512.536.7 Ii i i' i ii ii 01.01.06 i i i- i 2012 #12;i . i i i i i - i i ii I ii i i , i . i: i- , , ii i , i i i ii I , i i i. iii : i- , I , i i ii , i ii i i; i- i , i i ii , i. i 26 2012 . 15 i ii ii 35.051.18 i i

Banakh, Taras

433

and Induces Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Expression

  CiteSeer

Summary: Permissions: Requests for permissions to reproduce figures, tables, or portions of articles originally published in Circulation Research can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office. Once the online version of the published article for which permission is being requested is located, click Request Permissions in the middle column of the Web page under Services. Further information about this process is available in the Permissions and Rights Question and Answer document. Reprints: Information about reprints can be found online at:

Francesco Facchiano; Laura Maria Barlucchi; Guido Melillo; Barbara Illi; Lucia Testolin; Carlo Gaetano; Maurizio C. Capogrossi; Circ Res; Francesco Facchiano; Laura Maria Barlucchi; Guido Melillo; Barbara Illi; Lucia Testolin; Carlo Gaetano; Maurizio C. Capogrossi

434

ii i i , i i i i ii I

  Mathematics Websites

Summary: ii i i , i i i i ii I I 512.536.7 Ii i i' i ii ii 01.01.06 i i i- i i , i- , , ii i 2012 #12;2 I 3 i 1. i, i i - ii ii 11 1.1. I i, i i i 11 1.2. i ii . . . . . . . . . . . . . . 19 i 2. i i'- i - 33 2.1. i i i I (N) . . . . . . . . . . 35 2.2. ii i i i

Banakh, Taras

435

Short Communication Reproduction of honeybee workers is regulated by epidermal growth

  Biology and Medicine Websites

Summary: Short Communication Reproduction of honeybee workers is regulated by epidermal growth factor Keywords: Reproductive division Epidermal growth factor receptor Fertility Hymenoptera Honeybee Apis, also induces reproduc- tion in worker honeybees (Apis mellifera). These data show that worker fertility

Wenseleers, Tom

436

11 IIS1110 00 IIS010 0101244IIS

  Mathematics Websites

Summary: 10100 10 IIS 101010 100 00010111 111 001 325 Institute of Information Science 0000041 01 1561 3 431 FromtheNetherlandsto Poland What's Inside Newsletter of the Institute of Information Science Academia of Information Science The Institute of Information Science (IIS) was established in 1982. We currently have 38

Chen, Sheng-Wei

437

Growth index with the cosmological constant

  General Relativity & Quantum Cosmology (arXiv)

Summary: We obtain the exact analytic form of the growth index at present epoch ($a=1$) in a flat universe with the cosmological constant ({\\it i.e.} the dark energy with its equation of state $\\omega_{de} = -1$). For the cosmological constant, we obtain the exact value of the current growth index parameter $\\gamma = 0.5547$, which is very close to the well known value 6/11. We also obtain the exact analytic solution of the growth factor for $\\omega_{de}$ = -1/3 or -1. We investigate the growth index and its parameter at any epoch with this exact solution. In addition to this, we are able to find the exact $\\Omega_{m}^{0}$ dependence of those observable quantities. The growth index is quite sensitive to $\\Omega_{m}^{0}$ at $z = 0.15$, where we are able to use 2dF observation. If we adopt 2dF value of growth index, then we obtain the constrain $0.11 \\leq \\Omega_{m}^{0} \\leq 0.37$ for the cosmological constant model. Especially, the growth index is quite sensitive to $\\Omega_{m}^{0}$ around $z \\leq 1$. We might be able to obtain interesting observations around this epoch. Thus, the analytic solution for this growth factor provides the very useful tools for future observations to constrain the exact values of observational quantities at any epoch related to growth factor for $\\omega_{de} = -1$ or -1/3.

Seokcheon Lee; Kin-Wang Ng
2009-07-09

438

Bioclimatology Water deficits during reproductive growth

  Physics Websites

Summary: of water status under field controlled conditions, comparing an irrigated check with treatments with im- posed water deficiencies. Statistically significant differences were found between treatments in predawnBioclimatology Water deficits during reproductive growth of soybeans. II. Water use and water

Paris-Sud XI, Université de

439

15. Tracey KJ, Cerami A. Tumor necrosis factor, other cytokines

  CiteSeer

Summary: growth factor as a local mediator of the neurotrophic action of vitamin B 12 (cobalamin) in the rat central nervous system. FASEB J 1999;13:2083–2090. 7. Peracchi M, Bamonti Catena F, Pomati M, et al. Human cobalamin deficiency: alterations in serum tumour necrosis factor- ? and epidermal growth factor. Eur J Haematol 2001;

Scalabrino G; Nicolini G; Buccellato Fr; Et Al. Epidermal; Yamada M; Ikeuchi T; Hatanaka H. The Neurotrophic Action

440

Growth Strategies

  CiteSeer

Summary: This is an attempt to derive broad, strategic lessons from the diverse experience with economic growth in last fifty years. The paper revolves around two key arguments. One is that neoclassical economic analysis is a lot more flexible than its practitioners in the policy domain have generally given it credit. In particular, first-order economic principles—protection of property rights, market-based competition, appropriate incentives, sound money, and so on—do not map into unique policy packages. Reformers have substantial room for creatively packaging these principles into institutional designs that are sensitive to local opportunities and constraints. Successful countries are those that have used this room wisely. The second argument is that igniting economic growth and sustaining it are somewhat different enterprises. The former generally requires a limited range of (often unconventional) reforms that need not overly tax the institutional capacity of the economy. The latter challenge is in many ways harder, as it requires constructing over the longer term a sound institutional underpinning to endow the economy with resilience to shocks and maintain productive dynamism. Ignoring the distinction between these two tasks leaves reformers saddled with impossibly ambitious, undifferentiated, and impractical policy agendas.

Dani Rodrik
2003-01-01

441

Growth and Ideas

  CiteSeer

Summary: INTRODUCTION People in countries like the United States are richer by a factor of about 10 or 20 than people a century or two ago. Whereas U.S. per capita income today is $33,000, conventional estimates put it at $1800 in 1850. Yet even this difference likely understates the enormous increase in standards of living over this period. Consider the quality of life of the typical American in the year 1850. Life expectancy at birth was a scant 40 years, just over half of what it is today. Refrigeration, electric lights, telephones, antibiotics, automobiles, skyscrapers, and air conditioning did not exist, much less * This is a draft of a chapter for the Handbook of Economic Growth. I am grateful to Philippe Aghion and Paul Romer for helpful comments, and to the National Science Foundation for research support. the more sophisticated technologies that impact our lives daily in the 21st century. Perhaps the central question of the literature on economic growth is "Why is there growth at

Charles I. Jones
2004-01-01

442

Americans Want Smarter Growth. Smart Growth America

  Energy Storage, Conversion and Utilization Websites

Summary: Americans Want Smarter Growth. Smart Growth America Here's how to get there. #12;uring the past scarce. D 1 Americans' Attitudes about Growth are Changing As people strive to improve the livability quality of life. They are demanding smarter growth. ? Table of Contents 1 Chapter 1: Americans' Attitudes

Handy, Susan L.

443

Factorization on a Riemann surface in scattering theory

  Mathematics Websites

Summary: of factorization of the Jones matrices (Jones, 1984) and, in particularly, factorization of the Chebotarev matrix which eliminates the exponential growth of the factors. In order the factors to have an algebraicFactorization on a Riemann surface in scattering theory Y.A. Antipov 1 , V.V. Silvestrov 2 1

Bath, University of

444

TARGETED INHIBITION OF SP1 TRANSCRIPTION FACTOR AND ANTI-ANGIOGENESIS OF HUMAN PANCREATIC CANCER.

  Open Access Theses and Dissertations

Summary: ??Transcription factor Specificity Protein 1(Sp1) is reported to be essential for vascular endothelial growth factor (VEGF) constitutive expression in human pancreatic adenocarcinoma. The definitive role… (more)

Jia, Zhiliang
2010-01-01

445

II. EvaporationII. Evaporation Vaporization

  Materials Science Websites

Summary: II. EvaporationII. Evaporation Vaporization (mtorr) cm Line-of-sight transport Liu, UCD Phy250-1, 2011, NanoFab #12;Evaporation SourceEvaporation Source & compatibility #12;Evaporation SourceEvaporation Source Electron-beamInduction Electron-beamInduction Liu, UCD

Liu, Kai

446

Comportamento eletroquímico dos metais Co(II), Ni(II), Mn(II), Fe(II) e Zn(II) na presença do ligante azoteto.

  Open Access Theses and Dissertations

Summary: ??O comportamento eletroquímico dos metais cobalto(II), níquel(II), manganês(II), ferro(II) e zinco(II) na presença do ligante azoteto foi estudado em duas condições: variando-se a concentração do… (more)

Claudia Giovedi
1998-01-01

447

Non Commutative Bianchi type II Quantum Cosmology

  General Relativity & Quantum Cosmology (arXiv)

Summary: In this paper we present the noncommutative Bianchi Class A cosmological models coupled to barotropic perfect fluid. The commutative and noncommutative quantum solution to the Wheeler-DeWitt equation for any factor ordering, to the anisotropic Bianchi type II cosmological model are found, using a stiff fluid ($\\gamma=1$). In our toy model, we introduce noncommutative scale factors, is say, we consider that all minisuperspace variables $\\rm q^i$ does not commute, so the simplectic structure was modified.

M. Aguero; J. A. Aguilar S.; C. Ortiz; M. Sabido; J. Socorro
2007-03-29

448

Zeus at HERA II

  HEP - Experiment (arXiv)

Summary: The ZEUS detector has been upgraded in a number of areas to prepare for the physics opportunities of HERA II. These upgrades, and their physics rationale and promise, are briefly outlined. The measurement of polarisation at HERA II, and its importance for the HERA II physics programme, is also discussed.

B. Foster
2001-07-24

449

-PTOLEMY II -HETEROGENEOUS CONCURRENT

  Engineering Websites

Summary: -PTOLEMY II - HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Mudit Goel University of California at Berkeley http://ptolemy.eecs.berkeley.edu Memorandum UCB/ERL M99/40 Document Contents Part 1: Using Ptolemy II 1. Introduction 1-1 1.1.Modeling and Design 1-1 1.2.Architecture Design 1


450

-PTOLEMY II -HETEROGENEOUS CONCURRENT

  Engineering Websites

Summary: -PTOLEMY II - HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Christopher of Electrical Engineering and Computer Sciences University of California at Berkeley http://ptolemy with Ptolemy II 1.0 March 15, 2001 This project is supported by the Defense Advanced Research Projects Agency


451

Analysis II Intro Problem

  Computer Technologies and Information Sciences Websites

Summary: Algebra MATH 233 Multivariate Calculus ECE 303 Junior Seminar ECE 242 Data Structures ECE 232 Hardware ECE Electronics I MATH 131 Calculus I MATH 132 Calculus II MATH 331 Differential Equations ECE 333 Fields & Waves ECE 584 Microwaves I ECE 585 Microwaves II PHYS 151 Physics I PHYS 152 Physics II MATH 235 Linear

Massachusetts at Amherst, University of

452

I I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII

  Multidisciplinary Databases and Resources Websites

Summary: I I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII IIIIIIIIIIIIIIIIII I II I I I II I I I II I I I II I I I II I I I II I I I II I I I II I I I I I IIIIIIIIIIIIIIIIIIIII I II I I I II I I I II I I


454

RESEARCH ARTICLE Growth control by a moving morphogen gradient during

  Physics Websites

Summary: , organs grow to stereotyped sizes, but growth control mechanisms are poorly understood. Here, we measured the signaling dynamics of the morphogen Dpp, one of several Drosophila factors controlling morphogenetic growth dynamics of the wing disc, we previously proposed a temporal model for morphogenetic growth control

Jülicher, Frank

455

Fuzzy closure operators II: induced relations, representation, and examples

  Computer Technologies and Information Sciences Websites

Summary: Fuzzy closure operators II: induced relations, representation, and examples RADIM B LOHL VEK, Czech Republic, belohlav@osu.cz Abstract. Closure operators (and related structures) are investigated study relations induced by fuzzy closure operators (fuzzy qua- siorders and similarities); factorization

Belohlavek, Radim

456

Tutorial II Newtonian Cosmology; Hubble Expansion; Observational

  Physics Websites

Summary: for a matter- dominated FRW Universe. 1 #12;Exercise 2: Hubble Expansion and Bounded Objects We have seen a Friedmann Universe needed (yet), · On the basis of a Taylor series expansion of the expansion factor aTutorial II Newtonian Cosmology; Hubble Expansion; Observational Cosmology Exercise 1: Newtonian

Weijgaert, Rien van de

457

Statistical method II Pi-Wen Tsai

  Mathematics Websites

Summary: Analysis of Variance: Design and analysis of experiments by Montgomery D.C. Generalized Linear Models Continuous binary Nominal, ordinal (> 2 categories) Analysis of variance Continuous nominal+some continuous Analysis of covariance Pi-Wen Tsai () Statistical method II 2010 4 / 10 #12;1 Factor: A set of related

Tsai, Pi-Wen

458

Algebra Moderna II, 2008-II Michael Barot

  Mathematics Websites

Summary: Algebra Moderna II, 2008-II Michael Barot Fecha de entrega: 22/02/2008 http://www.matem.unam.mx/barot/cursos/2008-2.html Serie 1 1j En R = Z � Z se define (a, b) + (c, d) = (a + c, b + d) y (a, b) · (c, d) = (ac, ad+bc). Verifica que (R, +, ·) es un anillo, indica los neutros 0R, 1R, determina los divisiores de

Barot, Michael

459

STUDY OF THE EFFECTS OF HEAVY METALS ON SEED GERMINATION AND PLANT GROWTH ON ALFALFA PLANT (Medicago sativa) GROWN IN SOLID MEDIA

  CiteSeer

Summary: Preliminary studies have shown that alfalfa plants (Medicago sativa) can grow in some heavy metalcontaminated soils. Based on that, we studied the individual effects of several doses of Cd(II), Cr(VI), Cu(II), Ni(II), and Zn(II) on the growth of live alfalfa plants using solid media. The doses used in this study were 0, 5,

unknown authors

460

Air War College Nonresident Studies Directorate. ii Contents

  CiteSeer

Summary: Disclaimer....................................................................................................................................... ii Tables............................................................................................................................................. iv

Teresa M. Pitts; Lt Col
2007-01-01

461

PTOLEMY II HETEROGENEOUS

  Engineering Websites

Summary: ­PTOLEMY II ­ HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Ron Galicia Mudit University of California at Berkeley http://ptolemy.eecs.berkeley.edu Document Version 0.1.1 February 12 Syntaxes 1­6 1.5. Ptolemy II 1­7 1.5.1. Package Structure 1­7 1.5.2. Overview of Key Classes 1­9 1


462

-PTOLEMY II -HETEROGENEOUS

  Engineering Websites

Summary: -PTOLEMY II - HETEROGENEOUS CONCURRENT MODELING AND DESIGN IN JAVA John Davis, II Ron Galicia Mudit University of California at Berkeley http://ptolemy.eecs.berkeley.edu Document Version 0.1.1 February 12.2.8. Timed CSP and Timed PN 1-5 1.3.Choosing Models of Computation 1-6 1.4.Visual Syntaxes 1-6 1.5.Ptolemy II


463

Bayes Factors

  CiteSeer

Summary: In a 1935 paper, and in his book Theory of Probability, Jeffreys developed a methodology for quantifying the evidence in favor of a scientific theory. The centerpiece was a number, now called the Bayes factor, which is the posterior odds of the null hypothesis when the prior probability on the null is one-half. Although there has been much discussion of Bayesian hypothesis testing in the context of criticism of P -values, less attention has been given to the Bayes factor as a practical tool of applied statistics. In this paper we review and discuss the uses of Bayes factors in the context of five scientific applications in genetics, sports, ecology, sociology and psychology.

Robert E. Kass; Adrian E. Raftery
1995-01-01

464

Fibrin Matrices With Affinity-Based Delivery Systems and Neurotrophic Factors Promote

  Biology and Medicine Websites

Summary: ARTICLE Fibrin Matrices With Affinity-Based Delivery Systems and Neurotrophic Factors Promote ABSTRACT: Glial-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) have both been shown. The delivery of either growth factor at the site of injury may, therefore, result in quantitative differences

Moran, Daniel

465

Abstracts ii Schedule....................................................................................................................................................... iii

  Physics Websites

Summary: ...............................................................................................3 HAD II Special: Neptune after One Orbit: Reflections on the Discovery of a Planet ...........................................................................................5 Kavli Lecture: Cassini Eyes the Rings of Saturn

Ciotti, Luca

466

STUDY OF THE EFFECTS OF HEAVY METALS ON SEED GERMINATION AND PLANT GROWTH ON ALFALFA PLANT (Medicago sativa) GROWN IN SOLID MEDIA

  CiteSeer

Summary: Preliminary studies have shown that alfalfa plants (Medicago sativa) can grow in some heavy metalcontaminated soils. Based on that, we studied the individual effects of several doses of Cd(II), Cr(VI), Cu(II), Ni(II), and Zn(II) on the growth of live alfalfa plants using solid media. The doses used in this study were 0, 5, 10, 20, and 40 ppm. The seed germination and plant growth was significantly affected by Cd(II) and Cr(VI) at 10 ppm, as well as by Cu(II) and Ni(II) at 20 ppm and higher concentrations (P<1%). Zn(II) did not affect seed germination. The roots of the plants exposed to 5 ppm-dose of Cd(II), and 5 and 10 ppm-dose of Cr(VI), Cu(II), Ni(II), and Zn(II), grew more than the roots of the control treatment by more than 30%. Exposures of 5 ppm of Cd(II) reduced the shoot size by 16 % as compared to the control. While Cr(VI), Cu(II), Ni(II), and Zn(II) increased the shoot size by 14.0%, 60.0%, 36.0%, and 7.7%, respectively; only Zn(II) promoted the shoot growth at the doses of 20 and 40 ppm.

J. R. Peralta; J. L. Gardea-torresdey; K. J. Tiemann; E. Gómez; S. Arteaga; E. Rascon

467

Arthropod Growth & Development

  Biology and Medicine Websites

Summary: these limits, growth does not occur. Legs in larvae Ametabolous and hemimetabolous nymphs usually have the same1 Arthropod Growth & Development Some Basics The processes of growth and development are called ontogeny These are not necessarily the same thing, however Growth typically refers to changes in body size

Brown, Christopher A.

468

Growth Cones Contain Myosin II Bipolar Filament Arrays

  Biology and Medicine Websites

Summary: force [Bridgman et al., 2001; Tullio et al., 1996]. Partially as a consequence of the reduced traction force, axonal outgrowth rates of knock- out neurons are slowed [Tullio et al., 2001; Bridgman et al

Bridgman, Paul C.

469

The Prospective Association of Serum Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-1 Levels with All Cause and Cardiovascular Disease Mortality in Older Adults: The Rancho Bernardo Study

  CiteSeer

Summary: The IGF system has been implicated in cardiovascular disease (CVD) development. The prospective association of serum IGF-I and IGF-binding protein-1 (IGFBP-1) with all cause, ischemic heart disease (IHD), and non-IHD CVD mortality was examined in 633 men and 552 nonestrogen-using postmenopausal women, aged 51–98 yr (mean, 74 yr) in 1988–1992, who were followed through July 2001 (96 % follow-up). During the 9- to 13-yr follow-up, there were 522 deaths; 224 were attributed to CVD, and 105 were caused by IHD. IGF-I and IGFBP-1 were independently and jointly related to risk of IHD mortality. In a proportional hazards model including both IGF-I and IGFBP-1 and adjusting for CVD risk factors, the relative THE IGF SYSTEM has been implicated in the development of cardiovascular disease (CVD). IGF-I stimulates nitric oxide production from both the endothelium and vascular

Gail A. Laughlin; Elizabeth Barrett-connor; Michael H. Criqui

470

Integrable mappings and polynomial growth

  CERN Preprints

Summary: We describe birational representations of discrete groups generated by involutions, having their origin in the theory of exactly solvable vertex-models in lattice statistical mechanics. These involutions correspond respectively to two kinds of transformations on $q \\times q$ matrices: the inversion of the $q \\times q$ matrix and an (involutive) permutation of the entries of the matrix. We concentrate on the case where these permutations are elementary transpositions of two entries. In this case the birational transformations fall into six different classes. For each class we analyze the factorization properties of the iteration of these transformations. These factorization properties enable to define some canonical homogeneous polynomials associated with these factorization properties. Some mappings yield a polynomial growth of the complexity of the iterations. For three classes the successive iterates, for $q=4$, actually lie on elliptic curves. This analysis also provides examples of integrable mappings in ...

Boukraa, S; Rollet, G
1994-01-01

471

Department of Mathematics 4.4: Introduction to Factoring

  Engineering Websites

Summary: be factored. 2. Basic Forms (a) Formulas of Squares: I. Difference of two squares a2 - b2 = (a + b)(a - b) IIUNLV Department of Mathematics §4.4: Introduction to Factoring 1. Greatest Common Factor (a in reverse. We consider two basic forms: i. The leading coefficient is 1: x2 + bx + c ii. The leading

Ahmad, Sajjad

472

Montag Dienstag Mittwoch Donnerstag Freitag Analysis II VL Analysis II VL

  Computer Technologies and Information Sciences Websites

Summary: Montag Dienstag Mittwoch Donnerstag Freitag Analysis II VL Analysis II VL Lineare Algebra II Ã? Analysis I Ã? Analysis II GÃ? Praktische Informatik II GÃ? Praktische Informatik II Ã? Lineare Algebra II A VL Analysis I Ã? Lineare Algebra II A VL Praktische Informatik II Ã? Lineare Algebra II Ã? Lineare Algebra II Ã?

Mannheim, Universität

473

Strange Attractor in Immunology of Tumor Growth

  Nonlinear Sciences (arXiv)

Summary: The time delayed cytotoxic T-lymphocyte response on the tumor growth has been developed on the basis of discrete approximation (2-dimensional map). The growth kinetic has been described by logistic law with growth rate being the bifurcation parameter. Increase in the growth rate results in instability of the tumor state and causes period-doubling bifurcations in the immune+tumor system. For larger values of tumor growth rate a strange attractor has been observed. The model proposed is able to describe the metastable-state production when time series data of the immune state and the number of tumor cells are irregular and unpredictable. This metastatic disease may be caused not by exterior (medical) factors, but interior density dependent ones.

Margarita Voitikova
1997-08-21

474

Growth and Yield of Giant Sequoia1 David J. Dulitz 2

  Environmental Sciences and Ecology Websites

Summary: Growth and Yield of Giant Sequoia1 David J. Dulitz 2 Abstract: Very little information exists concerning growth and yield of giant sequoia (Sequoiadendron giganteum [Lindl.] Buchholz). For old-growth trees, diameter growth is the single factor adding increment since maximum height has been obtained

Standiford, Richard B.

475

Intracellular control of developmental and regenerative axon growth

  Biology and Medicine Websites

Summary: regulated process that requires stimulating signals from extracellular factors. The extracellular signals are then transduced to regulate coordinately gene expression and local axon assembly. Growth factors, especially neurotrophins that act via receptor tyrosine kinases, have been heavily studied as extracellular factors

Zhou, Fengquan

476

Clinical Study Time-Dependent Changes of Plasma Concentrations of Angiopoietins, Vascular Endothelial Growth Factor, and Soluble Forms of Their Receptors in Nonsmall Cell Lung Cancer Patients Following Surgical Resection

  CiteSeer

Summary: Copyright © 2012 Ewa Kopczy?ska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Even when patients with nonsmall cell lung cancer undergo surgical resection at an early stage, recurrent disease often impairs the clinical outcome. There are numerous causes potentially responsible for a relapse of the disease, one of them being extensive angiogenesis. The balance of at least two systems, VEGF VEGFR and Ang Tie, regulates vessel formation. The aim of this study was to determine the impact of surgery on the plasma levels of the main angiogenic factors during the first month after surgery in nonsmall cell lung cancer patients. The study group consisted of 37 patients with stage I nonsmall cell lung cancer. Plasma concentrations of Ang1, Ang2, sTie2, VEGF, and sVEGF R1 were evaluated by ELISA three times: before surgical resection and on postoperative days 7 and 30. The median of Ang2 and VEGF concentrations increased on postoperative day 7 and decreased on

Ewa Kopczy?ska; Maciej Dancewicz; Janusz Kowalewski; Roman Makarewicz; Hanna Kardymowicz; Agnieszka Kaczmarczyk; Tomasz Tyrakowski
2012-01-01

477

2008 Guidelines to Defra's GHG Conversion Methodology Paper for Transport Emission Factors

  Renewable Energy Websites

Summary: 2008 Guidelines to Defra's GHG Conversion Factors: Methodology Paper for Transport Emission Factors: Methodology Paper for Transport Emission Factors Contents I. INTRODUCTION 3 II. AVIATION 4 Previous Approach 4 New Passenger Air Transport Emission Factors 5 New Freight Air Transport Emission Factors 10 Other


478

Growth mechanism of nanostructured superparamagnetic rods obtained by electrostatic co-assembly

  Condensed Matter (arXiv)

Summary: We report on the growth of nanostructured rods fabricated by electrostatic co-assembly between iron oxide nanoparticles and polymers. The nanoparticles put under scrutiny, {\\gamma}-Fe2O3 or maghemite, have diameter of 6.7 nm and 8.3 nm and narrow polydispersity. The co-assembly is driven by i) the electrostatic interactions between the polymers and the particles, and by ii) the presence of an externally applied magnetic field. The rods are characterized by large anisotropy factors, with diameter 200 nm and length comprised between 1 and 100 {\\mu}m. In the present work, we provide for the first time the morphology diagram for the rods as a function of ionic strength and concentration. We show the existence of a critical nanoparticle concentration and of a critical ionic strength beyond which the rods do not form. In the intermediate regimes, only tortuous and branched aggregates are detected. At higher concentrations and lower ionic strengths, linear and stiff rods with superparamagnetic properties are produced. Based on these data, a mechanism for the rod formation is proposed. The mechanism proceeds in two steps : the formation and growth of spherical clusters of particles, and the alignment of the clusters induced by the magnetic dipolar interactions. As far as the kinetics of these processes is concerned, the clusters growth and their alignment occur concomitantly, leading to a continuous accretion of particles or small clusters, and a welding of the rodlike structure.

M. Yan; J. Fresnais; J. -F. Berret
2010-10-14

479

Clustering of photometric luminous red galaxies I : Growth of Structure and Baryon Acoustic Feature

  CERN Preprints

Summary: The possibility of measuring redshift space (RSD) distortions using photometric data have been recently highlighted. This effect complements and significantly alters the detectability of baryon acoustic oscillations (BAO) in photometric surveys. In this paper we present measurements of the angular correlation function of luminous red galaxies (LRGs) in the photometric catalog of the final data release (DR7) of the Sloan Digital Sky Survey II (SDSS). The sample compromise ~ 1.5 x 10^6 LRGs distributed in 0.45 < z < 0.65, with a characteristic photometric error of ~ 0.05. Our measured correlation centered at z=0.55 is in very good agreement with predictions from standard LCDM in a broad range of angular scales, $0.5^\\circ < \\theta < 6^\\circ$. We find that the growth of structure can indeed be robustly measured, with errors matching expectations. The velocity growth rate is recovered as $f \\sigma_8 = 0.53 \\pm 0.42$ when no prior is imposed on the growth factor and the background geometry follows a LC...

Crocce, Martin; Cabre, Anna; Carnero, Aurelio; Sanchez, Eusebio
2011-01-01

480

I.., . ., .. ii i i i

  Physics Websites

Summary: i i ¡ ¢ £ ¤¥ I I ' & $ % I.., . ., .. ii i i i : ICMP­03­18U I : 535.37 PACS: 75.30.Cr; 75.50.Mm; 61.44.Br; 32.50.+d ii i i i - : I.., .., .. i. i i , ii i i i - ii i ii, i i i - i . i i i , i iii i. i i i i i i . i i i, i ii i - i i i


481

~]~ERSPECTIVES Almost all of the studies to date in which growth

  Biology and Medicine Websites

Summary: ~]~ERSPECTIVES Almost all of the studies to date in which growth factors have been assessed with soluble growth factors. Nanogram per ml concentrations of activin, TGF-]32 and the FGFs can all cause some to differentiate into mesodernt All of the factors identified to date are related either tofibroblast growthfactor

Stern, Claudio

482

Population GrowthPopulation Growth Population Parameters

  Environmental Sciences and Ecology Websites

Summary: of change in population size · Four parameters influence population growth ­ Births ­ Deaths ­ Immigration ­ Emigration Population Growth · Births (b) = NATALITY ­ addition of individuals due to birth/hatching/etc. ­ expressed as # births/unit time ­ (b) is a rate function · Crude birthrate ­ # births/unit time/1000

Cochran-Stafira, D. Liane

483

Personal Details I wish my gift to remain anonymous II

  Environmental Sciences and Ecology Websites

Summary: as appropriate) Name of account holder Account number II II II II II II II II Sort code II II ­ II II ­ II II Signed Date For office/bank use only. Pay to Brasenose College, Account Number: 50314226, Sort Code: 20

Oxford, University of

484

RISK SENSITIVE CONTROL AND AN OPTIMAL INVESTMENT MODEL (II)

  Mathematics Websites

Summary: RISK SENSITIVE CONTROL AND AN OPTIMAL INVESTMENT MODEL (II) W. H. Fleming1 and S. J. Sheu2 Brown University and Academia Sinica Abstract. We consider an optimal investment problem proposed by Bielecki and Pliska. The goal of the investment problem is to optimize the long term growth of expected utility

Sheu, Shuenn-Jyi

485

Observational links between AGN evolution and galaxy growth

  Astrophysics (arXiv)

Summary: There is growing interest in the possible link between the growth of supermassive black holes and the effect of feedback from them on galaxy growth. There are three areas of significant uncertainty: (i) the physics of the feedback; (ii) the prevalence and effectiveness of feedback; (iii) the link between the growth of black holes and their hosts. The 2QZ optical QSO survey indicates that luminous QSOs are relatively short-lived, and it has recently been shown that the observed bolometric luminosity density from all AGN and its evolution can be reproduced if black holes grew coevally with their galaxies, implying but not requiring a causal link between galaxy growth and black hole growth. At low redshifts there is some evidence that black hole and galaxy growth are starting to decouple.

L. Miller
2006-11-21

486

The Haar system in the preduals of hyperfinite factors

  CERN Preprints

Summary: We shall present examples of Schauder bases in the preduals to the hyperfinite factors of types $\\hbox{II}_1$, $\\hbox{II}_\\infty$, $\\hbox{III}_\\lambda$, $0 < \\lambda \\leq 1$. In the semifinite (respectively, purely infinite) setting, these systems form Schauder bases in any associated separable symmetric space of measurable operators (respectively, in any non-commutative $L^p$-space).

Potapov, Denis
2008-01-01

487

Human and Environmental Factors Influence Soil Faunal AbundanceMass

  Multidisciplinary Databases and Resources Websites

Summary: Human and Environmental Factors Influence Soil Faunal Abundance­Mass Allometry and Structure DANIEL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 II. Soil Faunal Descriptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 53 A. Data on Taxonomy, Average BodyMass, and Population Density 53 B. Environmental Data

Cohen, Joel E.

488

Does Financial Liberalization Spur Growth

  CiteSeer

Summary: We show that equity market liberalizations, on average, lead to a one percent increase in annual real economic growth over a five-year period. The effect is robust to alternative definitions of liberalization and does not reflect a business cycle effect. The channel of growth is both increased investment post liberalization which partially reflects a decreased cost of capital and increased factor productivity. The additional investment is largely financed by foreign capital leading to deteriorating trade balances. Some of the liberalization effect can be accounted for by coincidental macroeconomic reforms as well as financial development. However, our analysis shows that even after controlling for a broad range of variables, a statistically significant and economically important role is played by equity market liberalization. We appreciate the helpful comments of Wayne Ferson, Peter Henry, Ross Levine, Graciela Kaminsky,

Geert Bekaert; Campbell R. Harvey; Christian Lundblad; Han Kim; Luc Laeven; Michael Pagano; Vicente Pons; Tano Santos; Andrei Shleifer; René Stulz
2005-01-01

489

PNUTS/PP1 Regulates RNAPII-Mediated Gene Expression and Is Necessary for Developmental Growth

  MIT - DSpace

Summary: In multicellular organisms, tight regulation of gene expression ensures appropriate tissue and organismal growth throughout development. Reversible phosphorylation of the RNA Polymerase II (RNAPII) C-terminal domain (CTD) ...

Ciurciu, Anita

490

The Effects of saponins from Sapindus Rarakfruit on rumen microbes and host animal growth

  Physics Websites

Summary: The Effects of saponins from Sapindus Rarakfruit on rumen microbes and host animal growth A Thalib by capsule ingredients (treatment II). It is concluded that MES can improve ability of rumen microbes

Paris-Sud XI, Université de

491

Membership Applied for:............................................................................. Is this a new application YES II NO II

  Biology and Medicine Websites

Summary: :............................................................................. Is this a new application YES II NO II MR/MRS/MISS/MS/DR/PROF/Other (please state Prefer not to say II Do you consider yourself to have a disability Yes II No II If yes, are you happy disability? Yes II No II If yes: Hearing impairment II Visual impairment II Learning II Physical impairment

Miall, Chris

492

Jan Hendrik Bruinier II Anna von Pippich Fabrizio Andreatta -Milan, Italy II Massimo Bertolini -Essen, Germany II Siegfried Bcherer -

  Mathematics Websites

Summary: Massimo Bertolini - Essen, Germany II Siegfried Böcherer - Mannheim, Germany II Thanasis Bouganis - Durham II Jay Jorgenson - New York, USA II Winfried Kohnen - Heidelberg, Germany II Jürg Kramer - Berlin, Germany II Siddarth Sankaran - Bonn, Germany II Maryna Viazovska - Bonn, Germany II Tonghai Yang - Madison

Haller-Dintelmann, Robert

493

ii^-A ^"^m^

  Environmental Sciences and Ecology Websites

Summary: -^..;,^ :- '^y'-'^.^y ii^-A ^"^m^:: . .. i I ecnnicai Heport NMFS Circular Marine Flora and Fauna. Gentry. M. B. Hale, and J. M. Marchello. October 1972, iii -I- 175 p., 6 figs., 6 tables. For sale bv


494

MATHEMATICAL IN GRAPHTHEORY II

  Mathematics Websites

Summary: MATHEMATICAL STRUCTURES IN GRAPHTHEORY II Oliver Knill Harvard University JAN 16 2014JAN 16 #12. Ivashchenko 1994 also has edge operations ChenYauYeh 2001: edge operations not needed HOMOTOPY #12;8 6 4 3 2

Knill, Oliver

495

J. Phys. II France 3 (1993) 21-26 JANUARY 1993, PAGE 21 Classification

  Physics Websites

Summary: on non wettable surfaces are metastable below a critical thickness and evolve by nucleation and growth of dry holes. The boles are predicted here to open at constant velocity. ii) The collective triodes: they dewet I)y nucleation and growth of dry patches [6, 7]. Microscopic films are unstable and dewet

Paris-Sud XI, Université de

496

Type II1 factors with uncountably many nonconjugate Cartan subalgebras

  Mathematics Websites

Summary: conférences, aussi avec Ophélie, et merci d'avoir voulu être membre de mon jury. Mama en papa hebben mijn doctoraatsleven misschien wel van het meest nabij gevolgd. Ze zeggen soms dat ik thuis voor drie tel. Mama en papa

Vaes, Stefaan

497

Factorization semigroups and irreducible components of Hurwitz space. II

  CERN Preprints

Summary: This article is a continuation of the article with the same title (see arXiv:1003.2953v1). Let {\\rm $\\text{HUR}_{d,t}^{G}(\\mathbb P^1)$} be the Hurwitz space of degree $d$ coverings of the projective line $\\mathbb P^1$ with Galois group $G$ and having fixed monodromy type $t$ consisting of a collection of local monodromy types (that is, a collection of conjugacy classes of permutations $\\sigma$ of the symmetric group $\\mathcal S_d$ acting on the set $I_d=\\{1,...,d\\}$). We prove that if the type $t$ contains big enough number of local monodromies belonging to the conjugacy class $C$ of an odd permutation $\\sigma$ which leaves fixed $f_C\\geq 2$ elements of $I_d$, then the Hurwitz space {\\rm $\\text{HUR}_{d,t}^{\\mathcal S_d}(\\mathbb P^1)$} is irreducible.

Kulikov, Vik S
2010-01-01

498

Schurian vector space categories of polynomial growth

  Mathematics Websites

Summary: space categories. A list of all infinitely sincere schurian vector space categories of polynomial growth, ) of dimension vector d is called sincere if d0 = 0 and dY = 0 for all Y ind K. A vector space category K is called sincere if there exists a sincere indecomposable factor space of K. The vector space category K

Bekkert, Viktor

499

Plant physiology Growth of white lupin seedlings

  Physics Websites

Summary: is an important factor of stand establishment. The relationship between seed weight and germinationPlant physiology Growth of white lupin seedlings during the rosette stage as affected by seed size June 1992; accepted 7 December 1992) Summary — Mean seed weight has a major influence

Paris-Sud XI, Université de

500

dependence of transition frequencies for ions SiII, CrII, FeII, NiII, and ZnII V. A. Dzuba,1

  Physics Websites

Summary: in the sensitivity to the variation by comparing optical transitions for different atoms. In this case the fredependence of transition frequencies for ions SiII, CrII, FeII, NiII, and ZnII V. A. Dzuba,1 V. V 2002 We perform an improved calculation of the dependence ( e2 /hc) of the transition frequencies

Kozlov, Mikhail G

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