| Sample search results for: a2 pla2 activity |
| 1 | Group-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2 | ||
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Summary: activities. Phospholipases A2 Synthetic human Group IIA sPLA2 was a generous gift of Drs. T. Hackeng and J... , [2] where B2 and B5 are the activities obtained from the sPLA2-IIA and sPL-V assays, respectively. ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 2 | Genes encoding multiples forms of phospholipase A2 are expressed in immature forms of human leukemic blasts | ||
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Summary: leukemic blasts Letter to the Editor Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position... of malignant proliferation.3 Deregulated PLA2 activity contributes to the pathogenesis of several malignancies... desaturase ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 3 | Prostaglandins & other Lipid Mediators 77 (2005) 235248 Distinguishing phospholipase A2 types in biological | ||
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Summary: ; Phospholipase A2; MAFP; BEL; Indoxam; Dole assay; PLA2 activity assay; PIP2 Corresponding author. Tel.: +1 858... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 1. Introduction Phospholipase ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 4 | Identification of the Expressed Form of Human Cytosolic Phospholipase A2 (cPLA2 ) | ||
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Summary: Identification of the Expressed Form of Human Cytosolic Phospholipase A2 (cPLA2 ) cPLA2 3... In this study, we identify the principal splice variant of human cytosolic phospholipase A2 ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 5 | APMIS 114: 12730, 2006 C 2006 The Authors Printed in Denmark . All rights reserved | ||
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Summary: Helicobacter pylori in vitro. APMIS 2006;114:12730. Group IIA phospholipase A2 (PLA2-IIA) is an enzyme which... lymphoma, and gastric cancer (1). Phospholipase A2 (PLA2) is a lipolytic en- zyme that hydrolyzes... , and ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 6 | Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2 in Mouse Lung Fibroblasts*S | ||
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Summary: Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2 in Mouse Lung Fibroblasts... Group IVA cytosolic phospholipase A2 (cPLA2 ) initiates eicosanoid production; however, this pathway... exhibited much higher lysophospholipase ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 7 | The ABC's of Group IV cytosolic phospholipase A2 Karin Killermann Lucas, Edward A. Dennis* | ||
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Summary: December 2003 Abstract The three known human Group IV phospholipase A2 (PLA2) paralogs, Group IVA, IVB... , calcium-independent PLA2 activity was identified in the insect cell lysates, which can be inhibited... in the presence of BEL, enabling ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 8 | Cloning and Recombinant Expression of Human Group IIF-Secreted Phospholipase A2 | ||
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Summary: -secreted phospholipases A2 (sPLA2) form a diverse family of at least nine enzymes that hydrolyze phospholipids to release... expression of hGIIF sPLA2 in Escherichia coli shows that the enzyme is Ca2 -dependent, maxi- mally active... . ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 9 | Phospholipase A2 regulation of arachidonic acid mobilization Jesus Balsindea | ||
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Summary: Alonso Abstract Phospholipase A2 (PLA2) constitutes a growing superfamily of lipolytic enzymes... and lipox- ins. Multiple PLA2 enzymes are active within and surrounding the cell and these enzymes have... ; Phospholipase; In£ammation 1. ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 10 | Localization of various secretory phospholipase A2 enzymes in male reproductive organs | ||
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Summary: of transcripts for several secretory phospholipase A2 (sPLA2) enzymes in male genital organs. In this study, we... ; Prostaglandin; Male reproductive organ; Testis; Mouse 1. Introduction Secretory phospholipase A2 (sPLA2... ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 11 | Novel Human Secreted Phospholipase A2 with Homology to the Group III Bee Venom Enzyme* | ||
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Summary: of sPLA2 activity in the culture medium, indicating that the cDNA codes for a secreted enzyme. Using... . In recent years, it has been realized that phospholipases A2 (PLA2,1 EC 3.1.1.4) form a superfamily... phospholipases ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 12 | Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory | ||
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Summary: constitute the delayed phase of mast cell activation. Phospholipase A2 (PLA2),3 which liberates free fatty... of secretory phospholipase A2 (sPLA2) isozymes, and those having heparin affinity markedly ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 13 | Cloning and Recombinant Expression of a Novel Mouse-secreted Phospholipase A2* | ||
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Summary: ´decine, Avenue de Valombrose, 06107 Nice, France Secreted phospholipases A2 (sPLA2s) form a class of structurally... . Recombinant expression of mGIID sPLA2 in Escherichia coli indicates that the cloned sPLA2 is an ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 14 | Characterization and Differentiation-dependent Regulation of Secreted Phospholipases A2 in Human Keratinocytes and | ||
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Summary: phospholipases A2 (sPLA2) expressed in the skin are thought to be involved in epidermal barrier home- ostasis... Mammalian phospholipases A2 (PLA2) are now classified into 12 groups (IXII). They are further subdivided... ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 15 | Calcium-independent phospholipase A2 : structure and function Michelle V. Winstead, Jesus Balsinde, Edward A. Dennis * | ||
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Summary: acetylhydro- lase activity as well as phospholipase A2 activity [2,6]. Additionally, Group VIA PLA2 exhibits... phospholipases A2 Ca2 -Independent PLA2 activities ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 16 | Groups IV, V, and X Phospholipases A2s in Human Neutrophils ROLE IN EICOSANOID PRODUCTION AND GRAM-NEGATIVE BACTERIAL PHOSPHOLIPID HYDROLYSIS* | ||
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Summary: of enzyme(s) with phospholipase A2 (PLA2) activity from human neutrophils. We show that circulating human... MLP or opsonized zymosan results in the release of GV but not GX sPLA2 and most, if not all, of the ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 17 | Localization of Group V Phospholipase A2 in Caveolin-enriched Granules in Activated P388D1 Macrophage-like Cells* | ||
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Summary: Localization of Group V Phospholipase A2 in Caveolin-enriched Granules in Activated P388D1... stimulation by lipopolysaccharide involves the action of Group V secreted phospholipase A2 (PLA2), Group IV... cytosolic ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 18 | Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+ | ||
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Summary: , bacterial lipopolysaccharide; PAF, platelet-activating factor; PLA2, phospholipase A2; RFP, red fluorescent... the Group IV cytosolic phospholipase A2 (cPLA2) and the Group V secreted ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 19 | Potentiation of Tumor Necrosis Factor -induced Secreted Phospholipase A2 (sPLA2)-IIA Expression in Mesangial Cells | ||
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Summary: Potentiation of Tumor Necrosis Factor -induced Secreted Phospholipase A2 (sPLA2)-IIA Expression... in Mesangial Cells by an Autocrine Loop Involving sPLA2 and Peroxisome Proliferator-activated Receptor... secreted phospholipases ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 20 | Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2 Group X*S | ||
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Summary: and Biophysics, University of Washington, Seattle, Washington 98195 Secreted phospholipase A2 group X (sPLA2-X... -leucyl-phenylalanine-mediated cPLA2 activation. These results indicate that sPLA2-X ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 21 | Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2* | ||
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Summary: ), leading to activation of cytosolic phospholipase A2 (cPLA2) (35). cPLA2 liberates arachidonic acid... -/calmodulin-dependent protein kinase II (CaM kinase II), a decoder of Ca2 signals, and cytosolic phospholipase ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 22 | Role of Charge Properties of Bacterial Envelope in Bactericidal Action of Human Group IIA Phospholipase A2 against | ||
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Summary: phospholipases A2 (PLA2) po- tently kill Staphylococcus aureus. Highly cationic prop- erties of these PLA2... to PLA2. A diminished positive charge in PLA2 reduces ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 23 | Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels | ||
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Summary: ; accepted 10 April 2006 Abstract Secreted phospholipases A2 (sPLA2) form a group of low-molecular weight... A2 (PLA2) are enzymes that catalyze the hydrolysis of the ester bond at the sn-2 position of phospho... - saccaride; ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 24 | On the Diversity of Secreted Phospholipases A2 CLONING, TISSUE DISTRIBUTION, AND FUNCTIONAL EXPRESSION OF TWO NOVEL MOUSE | ||
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Summary: - creted phospholipases A2 (sPLA2s) has been identified in mammals. Here, we report the cloning in mice... transiently transfected in COS cells, sPLA2 activity was found to accumulate in cell medium, indicating... with the other mouse ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 25 | Secretory Phospholipase A2 A Multifaceted Family of | ||
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Summary: of sPLA2 activity. Currently, the contribution of selective phospholipase A2 inhibition in preventing... Medicine Group LLC Secretory phospholipase A2 (sPLA2 ) represents a class of enzymes that ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 26 | Assaying Phospholipase A2 Activity Christina C. Leslie and Michael H. Gelb | ||
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Summary: and then add 10 lL of 10% BSA. Finally add the Assaying Phospholipase A2 Activity 235 #12;desired amount of sPLA... 16 Assaying Phospholipase A2 Activity Christina C. Leslie and Michael H. Gelb Summary Mammalian... cells contain many structurally ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 27 | A novel anti-inflammatory role for secretory phospholipase A2 in immune | ||
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Summary: -inflammatory role that opposes the pro-inflammatory activity of group IIA sPLA2. Mechanistically, group V sPLA2... Phospholipase A2 (PLA2) comprise a diverse family whose members share the capacity to ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 28 | Activation, Inhibition, and Regiospecificity of the Lysophospholipase Activity of the 85-kDa Group IV Cytosolic | ||
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Summary: , as is the case for this enzyme's phospholipase A2 (PLA2) activity. In contrast, dioleoylglycerol, which... acting as a poor analogue of a diacylphospholipid substrate for the phospholipase A2 activ- ity of ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 29 | Cytosolic Phospholipase A2 (PLA2), but Not Secretory PLA2, Potentiates Hydrogen Peroxide Cytotoxicity in Kidney | ||
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Summary: Cytosolic Phospholipase A2 (PLA2), but Not Secretory PLA2, Potentiates Hydrogen Peroxide... Phospholipase A2 (PLA2) and reactive oxygen species have been implicated both individually ... |
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Source: Witzgall, Ralph - Naturwissenschaftliche Fakultät III - Biologie und Vorklinische Medizin, Universität Regensburg |
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Collection: Biology and Medicine |
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| 30 | Regulation of Delayed Prostaglandin Production in Activated P388D1 Macrophages by Group IV Cytosolic and Group V Secretory | ||
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Summary: phospholipase A2 (sPLA2) rather than Group IIA sPLA2 is involved in short term, imme- diate arachidonic acid... in the level of cytosolic phospholipase A2 (cPLA2) or COX-1 were ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 31 | ORIGINAL ARTICLE Dierentiation-Dependent Regulation of Secreted Phospholipases | ||
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Summary: phospholipases A2, the group VI Ca2 þ -independent phospholipases A2 and the group VII and VIII platelet-activating... of the novel subtypes of secreted phospholipases A2 has made clear that more than one ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 32 | Copyright 2005 by the American Society for Biochemistry and Molecular Biology, Inc. 2122 Journal of Lipid Research Volume 46, 2005 This article is available online at http://www.jlr.org | ||
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Summary: Abstract Cytosolic phospholipase A2 (cPLA2 ) is a mem- ber of the group IV family of intracellular... phospholipase A2 enzymes, but unlike the well-studied cPLA2 , it is constitu- tively bound to membrane... Phospholipases ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 33 | Secretory phospholipase A2 induces dendritic cell maturation Laure Perrin-Cocon1 | ||
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Summary: LDL: oxidized low density lipoprotein; PAF: platelet-activating factor; PLA2: phospholipase A2; PC: phosphatidyl... manuscript Eur J Immunol 08/2004; 34 2293-302 #12;Abstract High level of phospholipase A2 ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 34 | Distinct Arachidonate-releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 | ||
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Summary: augment IgE-dependent immediate production of leuk- otriene C4 and platelet-activating factor. sPLA2-IB... . Phospholipase A2 (PLA2),1 which catalyzes the hydrolysis of membrane glycerophospholipids to produce free fatty... ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 35 | Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2 ) and Comparison with | ||
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Summary: , and phospholipase A2 activities of the full set of mammalian cPLA2s were quantified. The relative level... lysophospholipase A2 activity comparable with the other isoforms (Table 4, entry 13) and relatively low ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 36 | Biochemistry and Physiology of Mammalian | ||
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Summary: Abstract Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of glycerophospholipids... - zymatically active secreted PLA2s (sPLA2s) and two ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 37 | Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute | ||
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Summary: phospholipids in response to cytokines. There is current interest in phospholipases A2 (PLA2)2 because... active investigation. In mouse blood platelets, disruption of the cPLA2- gene leads to a significant... ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 38 | CELLULAR & MOLECULAR BIOLOGY LETTERS Volume 12 (2007) pp 621 -632 | ||
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Summary: calcium-dependent phospholipase A2; DTNB 5,5'-dithio-bis(2-nitrobenzoic acid); MAPK mitogen-activated... , Ottawa, Ontario, Canada K1S 5B6 Abstract: Cytosolic calcium-dependent phospholipase A2 (cPLA2) has... and liver of hibernating ... |
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Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 39 | A BIFUNCTIONAL ROLE FOR GROUP IIA SECRETED PHOSPHOLIPASE A2 IN HUMAN RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTE ARACHIDONIC ACID METABOLISM. | ||
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Summary: inhibition alone, may not adequately block the activity- independent function of sPLA2-IIA. Phospholipase A2... secreted phospholipase A2 (sPLA2-IIA) is an important regulator of cytokine-mediated ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 40 | Function and Inhibition of Intracellular Calcium- | ||
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Summary: of phospholipase A2 (PLA2)1 : the well characterized Groups I, II, and III small Ca2 -dependent secretory... phospholipase A2s (sPLA2), the 85-kDa Group IV Ca2 -dependent cytosolic phos- pholipase ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 41 | Role of Phosphorylation and Basic Residues in the Catalytic Domain of Cytosolic Phospholipase A2 in Regulating | ||
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Summary: hydrolytic activity. Group IVA cytosolic phospholipase A2 (cPLA2 )3 specifi- cally hydrolyzes arachidonic... cytosolic phospholipase A2 (cPLA2 ) is regu- lated by phosphorylation and calcium-induced ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 42 | Cellular Arachidonate-releasing Function and Inflammation-associated Expression of Group IIF Secretory Phospholipase A2* | ||
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Summary: the cellular arachidonate (AA)-releas- ing function of group IIF secretory phospholipase A2 (sPLA2-IIF), a sPLA... phospholipase A2 (sPLA2)1 comprises a large fam- ily of lipolytic enzyme, in which 10 ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 43 | Distinct Roles in Signal Transduction for Each of the Phospholipase A2 Enzymes Present in P388D1 Macrophages* | ||
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Summary: of activation and substrate preferences of the two phospholipase A2s (PLA2s). Furthermore, the results suggest... group II phospholipase A2 (sPLA2) is the enzyme respon- sible for most of the AA ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 44 | Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages* | ||
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Summary: genes encode four different secretory phospholipase A2 (sPLA2) enzymes in mammals, namely the well... was detected in both resting and activated cells. In contrast, Group IIA sPLA2 message was undetectable... -mediated signal transduction. The ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 45 | Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2 in regulating interfacial kinetics and binding and cellular function | ||
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Summary: principally act to regulate cPLA2 hydrolytic activity. Group IVA cytosolic phospholipase A2 (cPLA2... UniversityofWashingtonHealthSciencesLibrariesonJanuary30,2009www.jbc.orgDownloadedfrom #12;2 Group IVA cytosolic phospholipase ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 46 | Regional Distribution, Ontogeny, Purification, and Characterization of the Ca2 | ||
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Summary: BRAIN Ca2 -INDEPENDENT PHOSPHOLIPASE A2 #12;homogenized, centrifuged, and assayed for PLA2 activities... , Indiana, U.S.A. Abstract: We purified an 80-kDa Ca2 -independent phospholipase A2 (iPLA2) from rat ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 47 | Characterization of Group X Phospholipase A2 as the Major Enzyme Secreted by Human Keratinocytes and its Regulation | ||
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Summary: constitutively released secreted phospholi- pase A2 activity into the cell culture supernatant, being re... and other secreted phos- pholipase A2 subtypes as well as secreted phospholi- pase A2 activity in cell... culture ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 48 | VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2 | ||
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Summary: as a marker of PLA2 activity (Murohara et al., 1998). Phospholipases A2 consist of a growing superfamily... A-IT; phospholipase A2, PLA2; and lyso-PAF acetyltransferase, lyso-PAF-AT) may participate in PAF ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 49 | Arachidonate Release and Eicosanoid Generation by Group IIE Phospholipase A2 | ||
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Summary: to cyclooxygenase (COX) enzymes for aug- mented PG generation (312). sPLA2-IIA can elicit AA release from activated... Abbreviations used: sPLA2, secretory phospholipase A2; AA, ara- chidonic acid; OA, oleic acid; PG, prostaglandin... Cl ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 50 | Group V Phospholipase A2-mediated Oleic Acid Mobilization in Lipopolysaccharide-stimulated P388D1 Macrophages* | ||
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Summary: phospholipase A2 and the group V secretory phospholipase A2 (sPLA2). Here we show that when the LPS-activated... triggers OA release. These data implicate a func- tionally active sPLA2 ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 51 | Annu. Rev. Pharmacol. Toxicol. 1999. 39:17589 Copyright c 1999 by Annual Reviews. All rights reserved | ||
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Summary: collection of signal-activated phospholipases are the phos- pholipase A2s. These enzymes hydrolyze the sn-2... . Direct cleavage of AA from the sn-2 position via phospholipase A2 (PLA2) is a key step in deacylation... ) in vitro assay of ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 52 | [CANCER RESEARCH 64, 69346940, October 1, 2004] Oncogenic Action of Secreted Phospholipase A2 in Prostate Cancer | ||
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Summary: of prostate cancer xenografts. Phospholipase A2 (PLA2) enzymes regulate the provision of arachidonic acid... to be elucidated. Phospholipase A2 (PLA2), catalyzes the hydrolysis of membrane glycerophospholipids, leading... ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 53 | Interfacial Binding of Bee Venom Secreted Phospholipase A2 to Membranes Occurs Predominantly by a Nonelectrostatic Mechanism | ||
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Summary: Vised Manuscript ReceiVed August 10, 2004 ABSTRACT: The secreted phospholipase A2 from bee venom (bvPLA2) contains... to electrostatics. Secreted phospholipases A2 (sPLA2)1 are 14-18 kDa, calcium-dependent, disulfide-rich ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 54 | Roles of Trp31 in High Membrane Binding and Proinflammatory | ||
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Summary: Kingdom Group V phospholipase A2 is a recently discovered secretory phospholipase A2 (PLA2) that has been... 357). In this study, we demonstrate that exogenous hsPLA2-V has much greater activity than does ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 55 | A pyrrolidine-based specic inhibitor of cytosolic phospholipase A2K blocks arachidonic acid release in a variety of mammalian cells | ||
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Summary: cytosolic phospholipase A2 K-isoform (cPLA2K). Pyrrolidine-1 inhibits cPLA2K by 50% when present at approx... produc- tion [6] and bactericidal activity [7]. An 87 kDa group IV cytosolic phospholipase A2 ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 56 | Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged | ||
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Summary: , this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression... new insight into the pathogenesis of gastric cancer progression and metastasis. Phospholipase A2 (PLA2... and lysophospholipids. One of the ... |
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Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University |
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Collection: Biology and Medicine |
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| 57 | 560 BMB reports http://bmbreports.org *Corresponding author. Tel: 608-263-1791; Fax: 608-263-1409; | ||
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Summary: event is the activation of phospholipase A2 (PLA2), which results in the hy- drolysis ofmembrane... disorders (4) are now available. This review focuses specifically on the role of phospholipase A2 ... |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 58 | Secreted Phospholipase A2 Group X Overexpression in Asthma and Bronchial Hyperresponsiveness | ||
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Summary: phospholipases A2: high activity of group V PLA2 to induce eicosanoid biosynthesis in neighboring inflam- matory... phospholipase A2 enzymes (sPLA2s) play key regulatory roles in the biosynthesis of ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 59 | Phosphorylation of Cytosolic Group IV Phospholipase A2 Is Necessary but Not Sufficient for Arachidonic Acid | ||
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Summary: -0601 Received November 24, 1999 Activation of the cytosolic Group IV phospholipase A2 (cPLA2) by agonists has... from its phospholipid storage sites is regulated by the activation of phospholipase A2s ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 60 | Copyright 2005 by the American Society for Biochemistry and Molecular Biology, Inc. 2488 Journal of Lipid Research Volume 46, 2005 This article is available online at http://www.jlr.org | ||
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Summary: phospholipase A2 2495 LPS-induced activation of GIVA PLA2 results in the activa- tion of low amounts of GV PLA2... and whether GIVA PLA2 activation increases the expression of GV ... |
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Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 61 | Serial Review: Redox-Regulated Phospholipase Signal Transduction Serial Review Editors: Henry J. Forman, Viswanathan Natarajan | ||
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Summary: is the activation of phospholipase A2 (PLA2), resulting in hydrolysis of membrane phospholipids and release of free... species; SNO, nitric oxide; MDA, malondialdehyde; HNE, 4-hydroxynonenal; PLA2, phospholipase ... |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 62 | *Biological Engineering Department, University of Missouri, Columbia, Missouri, USA Biochemistry Department, University of Missouri, Columbia, Missouri, USA | ||
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Summary: of phospholipases, studies to understand the role of phospho- lipases A2 (PLA2s) in cells in the CNS have been... -jB, nuclear factor-kappa B; PLA2, phospholipase A2; ROS, reactive oxygen species; ... |
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Source: Lee, James - Biological Engineering Department, University of Missouri-Columbia |
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Collection: Biology and Medicine |
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| 63 | Molecular Biology of the Cell Vol. 20, 42254234, October 1, 2009 | ||
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Summary: junctions (Taddei et al., 2008). Phospholipases A2 (PLA2s) constitute a large family of enzymes... -cadherin, occludin, and claudin-5 upon cPLA2 depletion and upon inhibition of its enzymatic activity using various... account for the observed ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 64 | Recombinant Production and Properties of Binding of the Full Set of Mouse Secreted Phospholipases A2 to the Mouse M-Type Receptor | ||
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Summary: ReceiVed NoVember 29, 2006 ABSTRACT: To date, 12 secreted phospholipases A2 (sPLA2s) have been... -type receptor is discussed on the basis of our current knowledge of sPLA2 functions. Secreted phospholipases A2... , these four ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 65 | Expression of phospholipases A2 in primary human lung macrophages Role of cytosolic phospholipase A2-in arachidonic acid release and platelet | ||
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Summary: : Arachidonic acid Platelet activating factor Phospholipase A2 Lung macrophage Eicosanoid Inflammation... (cPLA2) and secreted phospholipases A2 (sPLA2) to the generation of lipid mediators in human... by ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 66 | Expression of Phospholipases A2 and C in Human Corneal Epithelial Cells | ||
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Summary: -healing pro- cesses in human corneal epithelial cells (HCECs), expression of phospholipase A2s (PLA2s... within the cell.8 There are different families of phospholipases, among which the phospholipase A2s (PLA2... calcium ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 67 | Cytosolic Phospholipase A2-Is Necessary for Platelet-activating Factor Biosynthesis, Efficient Neutrophil-mediated Bacterial | ||
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Summary: Cytosolic Phospholipase A2- Is Necessary for Platelet-activating Factor Biosynthesis, Efficient... , University of Toronto, Toronto, Ontario M5S 3E2, Canada The role of a cytosolic phospholipase A2- (cPLA2... 2- ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 68 | Cloning and Recombinant Expression of a Structurally | ||
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Summary: set of secreted phospho- lipases A2 (sPLA2s) that liberate arachidonic acid from phospholipids... sPLA2s only over a short stretch of amino acids in the active site region. Northern blot and reverse... , suggesting that hGXII could have novel ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 69 | TheJournalofExperimentalMedicine JEM The Rockefeller University Press $15.00 | ||
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Summary: , including prostaglandins, is tightly controlled by the regulated action of phospholipase A2s (PLA2s... in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A2s (PLA2s), most notably... 2, ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 70 | Group V Phospholipase A2-dependent Induction of | ||
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Summary: the constitutive Group IV cytosolic phospholipase A2 (cPLA2) and the inducible Group V secretory phospholipase A2... of these effects was observed if inactive Group V sPLA2 was utilized, implying that enzyme ... |
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|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 71 | INFECTION AND IMMUNITY, Mar. 2006, p. 17511756 Vol. 74, No. 3 0019-9567/06/$08.00 0 doi:10.1128/IAI.74.3.17511756.2006 | ||
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Summary: of the host. In this study, we assessed the role of macrophage phospholipases A2 (PLA2s) in defense against M... in protecting the bacterium against innate defenses. Phospholipase A2 (PLA2) enzymes hydrolyze the sn-2 bond... ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 72 | Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum | ||
|
Summary: developed for all human secreted phospholipases A2 (PLA2), viz. group (G) IB, GIIA, GIID, GIIE, GIIF, GIII... Phospholipase A2 (PLA2) was first identified in snake venoms and mammalian pancreas [1]. A large number... were ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 73 | Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor [Journal Home Page] [Search the Journals] [Table of Contents] [PDF version of this article] [Download | ||
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Summary: secreted phospholipases A2 (sPLA2s) constitute a family of structurally related enzymes that are likely... -inflammatory therapeutic effects of sPLA2 inhibitors may be due not only to inhibition of enzymatic activity but also... phospholipases ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 74 | EOSINOPHIL CYSTEINYL LEUKOTRIENE SYNTHESIS MEDIATED BY EXOGENOUS SECRETED PHOSPHOLIPASE A2 GROUP X | ||
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Summary: A2 GROUP X Ying Lai,1 Rob C. Oslund,3 James G. Bollinger,3 William R. Henderson, Jr.,2 Luis F... 105.6 (6.6) LPS N >3937.5 sPLA2-X (100 nM) N 122.6 (19.8) Untreated Y 107.2 (9.5) LPS Y 105.5 (13.9) sPLA... ;2 Supplemental Table 2: Selectivity of ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 75 | Group X Secreted Phospholipase A2 Proenzyme Is Matured by a Furin-like Proprotein Convertase and Releases | ||
|
Summary: phospholipases A2 (sPLA2s), group X sPLA2 has the most potent hydrolyzing activity toward phosphatidylcholine... . The mammalian secreted phospholipases A2 ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 76 | Lung mast cells are a source of secreted phospholipases A2 Massimo Triggiani, MD, PhD,a | ||
|
Summary: . Results: Phospholipase A2 (PLA2) activity was higher in the BALF of asthmatic patients than in the control... , Italy, and Seattle, Wash Background: Secreted phospholipases A2 (sPLA2s) are released in ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
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| 77 | Edema Toxin Impairs Anthracidal Phospholipase A2 Expression by Alveolar | ||
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Summary: A2 (sPLA2-IIA) against B. anthracis. A component of innate immunity produced by alveolar macrophages... ,17]. This activity is the most significant biological property of sPLA2-IIA, being observed at much lower... A; SEM, standard error of the ... |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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|
Collection: Mathematics |
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| 78 | Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein Kinases* | ||
|
Summary: Serine 727 Phosphorylation and Activation of Cytosolic Phospholipase A2 by MNK1-related Protein... A2 (cPLA2) is phosphorylated on Ser-505 by p38 protein kinase and on Ser-727 by an unknown kinase... is responsible for in vivo phosphorylation of ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 79 | Proc. Natl. Acad. Sci. USA Vol. 95, pp. 79517956, July 1998 | ||
|
Summary: ) ABSTRACT Secretory phospholipase A2 (sPLA2) is the major effector involved in arachidonic acid (AA... that activation of the sPLA2 at the plasma membrane is highly dependent on previous acti- vation of the cytosolic... phospholipase ... |
|||
|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
|||
|
Collection: Biology and Medicine |
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| 80 | Localization of Structural Elements of Bee Venom Phospholipase A2 Involved in N-type Receptor Binding and Neurotoxicity* | ||
|
Summary: - cretory phospholipases A2 (sPLA2s) have specific recep- tors in brain membranes called N-type receptors... . Secretory phospholipases A2 (sPLA2s,1 14 kDa) catalyze the hydrolysis of the sn-2 position... to those of the other ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
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| 81 | Identification of a Third Pathway for Arachidonic Acid Mobilization and Prostaglandin Production in Activated P388D1 | ||
|
Summary: enzymes involved in both of these phases are the same, namely the cytosolic group IV phospholipase A2 (cPLA... not involved. Zymosan appears to signal exclusively through activation of the cPLA2, which is coupled... to generate a prostaglandin bio- synthetic response ... |
|||
|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 82 | Novel Mammalian Group XII Secreted Phospholipase A2 Lacking Enzymatic Morgane Rouault, James G. Bollinger,| Michel Lazdunski, Michael H. Gelb,| and Gerard Lambeau*, | ||
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Summary: Novel Mammalian Group XII Secreted Phospholipase A2 Lacking Enzymatic Activity, Morgane Rouault... number of mammalian secreted phospholipases A2 (sPLA2s) has been identified over the past few years. Here... , the GXIIB ... |
|||
|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
|||
|
Collection: Chemistry ; Biology and Medicine |
|||
| 83 | Neurobiology of Disease Phospholipases A2 Mediate Amyloid-Peptide-Induced | ||
|
Summary: that phospholipases A2 (PLA2s), namely the cytosolic and the calcium-independent PLA2s (cPLA2 and iPLA2 ), are key... . Key words: Alzheimer's disease (AD); amyloid- peptide (A ); ... |
|||
|
Source: Lee, James - Biological Engineering Department, University of Missouri-Columbia |
|||
|
Collection: Biology and Medicine |
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| 84 | Cellular Arachidonate-releasing Function of Novel Classes of Secretory Phospholipase A2s (Groups III and XII)* | ||
|
Summary: of secre- tory phospholipase A2s (sPLA2s), groups III and XII. Hu- man group III sPLA2 promoted spontaneous... . Human group XII sPLA2 had a weak enzymatic activity in vitro and minimally affects cellular ... |
|||
|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
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| 85 | Expression and characterization of human group V phospholipase A2 Yijun Chen, Edward A. Dennis * | ||
|
Summary: V phospholipase A2 ac- tivity on DPPC vesicles. The PLA2 activity assays were con- ducted at 40³C... head group preference of the group V phospholipase A2. Activity of PLA2 toward 100 ... |
|||
|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
|||
| 86 | Expression and function of phospholipase A2 in brain Mar|a A. Balboa1;2 | ||
|
Summary: by Edward A. Dennis, Isabel Varela-Nieto and Alicia Alonso Abstract Phospholipase A2 (PLA2) appears to play... as a model to study injury/ in£ammation-related activation of the new PLA2 forms GIVB and GIVC. ß 2002... 1. Introduction ... |
|||
|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 87 | Intracellular processing of group X sPLA2 in HEK293 cells Group X Secreted Phospholipase A2 Proenzyme Is Matured By a Furin-Like Proprotein Convertase | ||
|
Summary: . ------------------------------------ The mammalian secreted phospholipases A2 (sPLA2s) form a structurally-related family of up to 10 active enzymes... Intracellular processing of group X sPLA2 in HEK293 cells 1 Group X Secreted Phospholipase ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
|||
|
Collection: Chemistry ; Biology and Medicine |
|||
| 88 | Mini-review Localization and function of cytosolic phospholipase A2a at the Golgi | ||
|
Summary: phospholipase A2a (cPLA2a, Group IVA phospholipase A2) is a central mediator of arachidonate release from... RNA or pharmacological inhibition of enzymatic activity of cPLA2a affects fundamental cellular ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
|||
|
Collection: Chemistry ; Biology and Medicine |
|||
| 89 | Bactericidal Properties of Human and Murine Groups I, II, V, X, and XII Secreted Phospholipases A2* | ||
|
Summary: IIA secreted phospholipase A2 (sPLA2) is known to display potent Gram-positive bactericidal ac- tivity... . These studies show that highly basic sPLA2s display potent bactericidal activity with the exception... surface of the ... |
|||
|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
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| 90 | Interfacial Enzymology of Parvovirus Phospholipases A2* Received for publication, November 9, 2003, and in revised form, January 7, 2004 | ||
|
Summary: The capsid of parvoviruses proteins were recently shown to contain secreted phospholipase A2 (sPLA2)- like... activity that is required during host cell entry. Par- voviral PLA2 domains have little sequence identity... , and a comparison has been ... |
|||
|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
|||
| 91 | Cellular Regulation of Cytosolic Group IV Phospholipase A2 by Phosphatidylinositol Bisphosphate Levels1 | ||
|
Summary: mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin... * Cytosolic group IV phospholipase A2 (cPLA2) is a ubiquitously expressed enzyme with key roles... in ... |
|||
|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 92 | SPINAL PHOSPHOLIPASE A2 IN INFLAMMATORY HYPERALGESIA: ROLE OF THE SMALL, SECRETORY PHOSPHOLIPASE A2 | ||
|
Summary: . Secreted phospholipase A2s (sPLA2s) form a class of structurally related enzymes that release arachidonic... fluid were collected from rats for assessment of sPLA2 protein expres- sion and sPLA2 activity. ... |
|||
|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 93 | Identity between the Ca2 -independent Phospholipase A2 Enzymes | ||
|
Summary: -0601 and the §Genetics Institute, Cambridge, Massachusetts 02140 A novel Ca2 -independent phospholipase A2 (iPLA2) has... modification of the CHO enzyme by [3 H]bro- moenol lactone is dependent on active enzyme as is the P388D1 iPLA2... . ... |
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|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 94 | Cytosolic Phospholipase A2-A: A PotentialTherapeuticTarget for Prostate Cancer | ||
|
Summary: ,5,6 Abstract Purpose: Cytosolic phospholipase A2-a (cPLA2-a) provides intracellular arachidonic acid to supply... transcription-PCR,Western blot, andimmunocytochemistry. Growthinhibition, apoptosis, and cPLA2-a activity were... as well as ... |
|||
|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
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| 95 | Interfacial activation, lysophospholipase and transacylase activity of Group VI Ca2 | ||
|
Summary: ; accepted 30 March 1998 Abstract The Group VI 80-kDa Ca2 -independent phospholipase A2 (iPLA2) has been... phospholipid remodeling. We now report that the Group VI iPLA2 displays interfacial activation toward short... ... |
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|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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Collection: Biology and Medicine |
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| 96 | 20 5 26 17001830 Professor John A. Oates | ||
|
Summary: Pharmacology Division, () Cytosolic phospholipase A2 (cPLA2) hydrolyzes arachidonic acid from cellular membrane... of the patient's cPLA2 genes (p.[Ser111Pro]+[Arg485His; Lys651Arg]). The total PLA activity in sonicated... of Cytosolic ... |
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|
Source: Miyashita, Yasushi - Department of Physiology, University of Tokyo |
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Collection: Biology and Medicine |
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| 97 | UNIVERSITE DE NICE-SOPHIA-ANTIPOLIS -UFR Sciences Ecole Doctorale des Sciences de la Vie et de la Sant | ||
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Summary: qui pourrait être dépendante de l'activation de la phospholipase A2 cytosolique (cPLA2-) (125). Ces... ......................................................................................................... 1 II. Les phospholipases A2 ... |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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|
Collection: Mathematics |
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| 98 | Action of Human Group IIa Secreted Phospholipase A2 on Cell Membranes | ||
|
Summary: not modulate plasma membrane phospholipid hydrolysis by exogenously added hIIa-PLA2. The phospholipase A2 (PLA2... The abbreviations used are: PLA2, phospholipase A2; DAUDA, 11- ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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|
Collection: Chemistry ; Biology and Medicine |
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| 99 | Spinal phospholipase A2 in inflammatory hyperalgesia: role of Group IVA cPLA2 | ||
|
Summary: Spinal phospholipase A2 in inflammatory hyperalgesia: role of Group IVA cPLA2 1,3 Karin Killermann... . This cascade must originate with free arachidonic acid (AA) released by the activity of spinal phospholipase A2... blotting and ... |
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|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 100 | Antisense Inhibition of Group VI Ca2 -independent Phospholipase | ||
|
Summary: on the use of the Group VI Ca2 -independent phospholipase A2 (iPLA2) inhibitor bromoenol lactone (BEL), we... with a decrease in both iPLA2 activity and protein in the antisense-treated cells. Col- lectively these data... in P388D1 macrophages. ... |
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|
Source: Dennis, Edward A. - Department of Chemistry and Biochemistry, University of California at San Diego |
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|
Collection: Biology and Medicine |
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