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Sample search results for: leishmaniose visceral calazar

 

1

Alterações imunológicas no sangue periférico de cães submetidos à imunoprofilaxia para leishmaniose visceral canina.

  Open Access Theses and Dissertations

Summary: ??A leishmaniose visceral causada por Leishmania chagasi representa, no âmbito da interação parasito-hospedeiro, uma cadeia composta pela tríade homem-vetor-cão, na qual, os canídeos representam papel… (more)

Marcio Sobreira Silva Araujo
2006-01-01

2

Estudo das alterações clínico-laboratoriais e histopatológicas renais em cães com leishmaniose visceral naturalmente infectados no Distrito Federal.

  Open Access Theses and Dissertations

Summary: ??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, 2008. Considerando que os rins são freqüentemente acometidos na leishmaniose visceral canina, esse estudo visa… (more)

Dias, Cecília Azevedo
2008-01-01

3

Alteração testicular, epididimaria e do líquido cefalorraquidiano de cães (Canis familiaris) (Linnaeus,1758) naturalmente infectados por Leishmania(Leishmania) chagasi provenientes da Região Metropolitana do Recife.

  Open Access Theses and Dissertations

Summary: ??A leishmaniose visceral canina (LVC) ou calazar é uma doença sistêmica causada pelo protozoário da espécie Leishmania (Leishmania) chagasi. Sua transmissão realiza-se por insetos hematófagos… (more)

Fabiane Aragão Rodrigues
2006-01-01

4

Validação doTeste de Elisa com exoantígenos e da imunofluorescência direta para o diagnóstico da Leishmaniose Tegumentar Americana.

  Open Access Theses and Dissertations

Summary: ??Tese (doutorado)—Universidade de Brasília, Programa de Pós-Graduação em Ciências Médicas, 2011. A leishmaniose tegumentar americana (LTA) é um problema de saúde pública, cujo diagnóstico depende… (more)

Soares, Killarney Ataide
2011-01-01

5

Avaliação do perfil hipóxico e de marcadores de inflamação em lesões leishmanióticas induzidas por Leishmania amazonensis, nos modelos murinos pré e pós-tratamento anti leishmaniose.

  Open Access Theses and Dissertations

Summary: ??A leishmaniose experimental murina causada por Leishmania amazonensis é um modelo parasitário que apresenta variações no desenvolvimento da lesão dependendo da linhagem de camundongo utilizada,… (more)

Alexandra Paiva Araújo Vieira
2012-01-01

6

COMPARISON OF VISCERAL FAT AND GONADAL FAT VOWMES OF YELLOWTAIL

  Environmental Sciences and Ecology Websites

Summary: NOTES COMPARISON OF VISCERAL FAT AND GONADAL FAT VOWMES OF YELLOWTAIL ROCKFISH, SEBASTES FLAVIDUS 1964; Pereyra et al. 1969; Lorz et al. 1983). Annual cycles of visceral fat volume and gonad volume are documented in Guillemot (1982) and Guillemot et al. (1985). The studies showed that visceral fat volume


7

Role of Perivascular and Visceral Adipose Tissues in Murine Models of Obesity and Atherosclerosis: A Dissertation.

  Open Access Theses and Dissertations

Summary: ??Expansion of visceral adipose tissue correlates with the metabolic syndrome and increased cardiovascular risk. Hypertrophied visceral fat becomes inflamed, causing increased lipolysis, decreased triglyceride storage,… (more)

Fitzgibbons, Timothy P.
2012-01-01

8

Análise molecular de isolados do gênero leishmania e clínica de pacientes portadores de leishmaniose tegumentar americana atendidos no Hospital Universitário de Brasília.

  Open Access Theses and Dissertations

Summary: ??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2013. A Leishmaniose Tegumentar Americana é um grave problema… (more)

Graziani, Daniel
2013-01-01

9

Caracterização da atividade de tamoxifeno no tratamento da leishmaniose experimental e investigação sobre seus mecanismos de ação.

  Open Access Theses and Dissertations

Summary: ??The treatment of cutaneous and visceral leishmaniasis is challenging, since the drugs used are frequently ineffective, very toxic and require parenteral administration. Therefore, the discovery… (more)

Danilo Ciccone Miguel
2011-01-01

10

ATTITUDES AND SOCIAL COGNITION Visceral Fit: While in a Visceral State, Associated States of the World Seem More Likely

  CiteSeer

Summary: We propose that visceral states can influence beliefs through “visceral fit”: People will judge states of the world associated with their current visceral experience as more likely. We found that warmth influenced belief in global warming (Studies 1–3) and that thirst impacted forecasts of drought and desertification (Study 5). These effects emerged in a naturalistic setting (Study 1) and in experimental lab settings (Studies 2, 3, and 5). Studies 2–6 distinguished between 3 mechanistic accounts: temperature as information (Studies 2 and 3), conceptual accessibility (Studies 4 and 5), and fluency of simulation (Studies 6a and 6b). Studies 2 and 3 ruled out the temperature as information account. Feeling warm enhanced belief in global warming even when temperature was manipulated in an uninformative indoor setting, when participants ’ attention was first directed to the indoor temperature, and when participants ’ belief about the current outdoor temperature was statistically controlled. Studies 4 and 5 ruled out conceptual accessibility as the key mediator: Priming the corresponding concepts did not produce analogous effects on judgment. Studies 6a and 6b used a causal chain design and found support for a “simulational fluency ” account. Participants experiencing the visceral state of warmth constructed more fluent mental representations of hot (vs. cold) outdoor images, and those who were led to construe the same hot outdoor images more fluently believed more in global warming. Together, the results suggest that visceral states can influence one’s beliefs by making matching states of the world easier to simulate and therefore seem more likely.

Jane L. Risen; Clayton R. Critcher

11

Prevalência de oftalmopatias em cães naturalmente infectados com Leishmania (Leishmania) Chagasi no município de Belo Horizonte - Estudo clínico e Histopatológico.

  Open Access Theses and Dissertations

Summary: ??Dentre as doenças parasitárias sistêmicas com manifestação oftalmológica destaca-se a leishmaniose visceral canina, que pode determinar desde discretas alterações nos anexos oculares a envolvimento completo… (more)

Gustavo de Oliveira Fulgencio
2006-01-01

12

Avaliação da imunidade celular na pele de cães naturalmente infectados com Leishmania (Leishmania) infantum chagasi e sua correlação com transmissibilidade ao vetor.

  Open Access Theses and Dissertations

Summary: ??Foram selecionados aleatoriamente 38 cães naturalmente infectados por Leishmania (Leishmania) infantum chagasi oriundos de Araçatuba, São Paulo, área endêmica para leishmaniose visceral, e os quais… (more)

Claudio Nazaretian Rossi
2013-01-01

13

Lesões genitais em cadelas naturalmente infectadas com leishmania chagasi e soroconversão de cadelas acasaladas com cães portadores.

  Open Access Theses and Dissertations

Summary: ??A transmissão da leishmaniose visceral ocorre principalmente na presença do hospedeiro invertebrado, embora existam relatos de transmissão na ausência do vetor, inclusive a transmissão venérea… (more)

Fabiana Lessa Silva
2007-01-01

14

No evidence for association between SLC11A1 and visceral leishmaniasis in India

  University of Cambridge - Dspace

Summary: AbstractBackgroundSLC11A1 has pleiotropic effects on macrophage function and remains a strong candidate for infectious disease susceptibility. 5' and/or 3' polymorphisms have been associated with tuberculosis, leprosy, and visceral leishmaniasis (VL...

Mehrotra, Sanjana; Oommen, Joyce; Mishra, Anshuman; Sudharshan, Medhavi; Tiwary, Puja; Jamieson, Sarra E; Fakiola, Michaela; Rani, Deepa Selvi; Thangaraj, Kumarasamy; Rai, Madhukar; Sundar, Shyam; Blackwell, Jenefer M
2011-05-20

15

Running Head: Sex Differences in Brain Response to Visceral Pressure

  CiteSeer

Summary: Berman et al. 2 To explore sex differences in the response of seven brain regions to an aversive pelvic visceral stimulus, fMRI images were acquired from 13 healthy adults (6 women) during 15 s of cued rectal distension at two pressures: 25 mmHg (uncomfortable), and 45 mmHg (mild pain), as well as during an expectation condition (no distension). Random effects analyses combining subject data voxelwise found 45 mmHg pressure significantly activated the insular and anterior cingulate cortices in both sexes. In men only, the left thalamus and ventral striatum were also activated. Although all activations appeared more extensive in men, no sex difference attained significance. To explore the presence of deactivations, which are generally cancelled by more numerous activations when subjects are combined for each voxel, the number of activated voxels, number of deactivated voxels, and ratio of deactivated voxels to total voxels affected were assessed via random effects mixed model analyses combining subject data at the region level. Greater insula activation in men compared to women was seen during the expectation condition and during the 25 mmHg distension. Greater deactivations in women were seen in the amygdala (25 mmHg

Steven M. Berman; Bruce D. Naliboff; All Suyenobu; Jennifer S. Labus; Jean Stains; Joshua A. Bueller; Kim Ruby; Emeran A. Mayer; Address Correspondence To

16

Efeito do exercício de força sobre a adiposidade periférica e visceral, perfil lipídico, glicídico e hormonal em adolescentes obesos.

  Open Access Theses and Dissertations

Summary: ??Objetivo: Verificar as possíveis alterações provocadas pelos exercícios de força sobre a adiposidade periférica e visceral, perfil lipídico, glicídico e respostas hormonais, após doze semanas… (more)

Sérgio Garcia Stella
2006-01-01

17

Hedgehog and Wingless Induce Metameric Pattern in the Drosophila Visceral Mesoderm

  Biotechnology Websites

Summary: Hedgehog and Wingless Induce Metameric Pattern in the Drosophila Visceral Mesoderm David Bilder1 production of secreted signals encoded by the segment polarity genes hedgehog (hh) and wingless (wg system do not pattern the early endoderm. Instead, endoderm A­P patterning is induced at midem

Quake, Stephen R.

18

Beta-Cell Function and Visceral Fat in Lactating Women With a History of Gestational Diabetes

  Engineering Websites

Summary: Beta-Cell Function and Visceral Fat in Lactating Women With a History of Gestational Diabetes Ruth M. McManus, Ian Cunningham, Annette Watson, Lynda Harker, and Diane T. Finegood Lactation has been with comparison of results for lactating versus nonlactating women. A total of 26 women participated (14 BF and 12

Cunningham, Ian

19

Original article Canine visceral leishmaniasis caused by Leishmania infantum in Senegal

  Environmental Sciences and Ecology Websites

Summary: Original article Canine visceral leishmaniasis caused by Leishmania infantum in Senegal: risk, the number of positive PCRs, clinical signs and the number of Leishmania isolates. For the first time, the discriminative PCRs performed on canine Leishmania strains clearly evidenced that the pathogenic agent

Choisy, Marc

20

Differentiation of extraembryonic endoderm stem cell lines and parietal endoderm into visceral endoderm: the art of XEN cells 

  Edinburgh, University of - Research Archive

Summary: The extraembryonic endoderm of mammals is essential for nutritive support of the foetus and patterning of the early embryo. Visceral and parietal endoderm are major subtypes of this lineage with the former exhibiting ...

Paca, Agnieszka Maria
2012-06-22

21

Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice

  CiteSeer

Summary: SMAD4 serves as a common mediator for signaling of TGF-? superfamily. Previous studies illustrated that SMAD4-null mice die at embryonic day 6.5 (E6.5) due to failure of mesoderm induction and extraembryonic defects; however, functions of SMAD4 in each germ layer remain elusive. To investigate this, we disrupted SMAD4 in the visceral endoderm and epiblast, respectively, using a Cre-loxP mediated approach. We showed that mutant embryos lack of SMAD4 in the visceral endoderm (Smad4 Co/Co;TTR-Cre) died at E7.5-E9.5 without head-fold and anterior embryonic structures. We demonstrated that TGF-? regulates expression of several genes, such as Hex1, Cer1, and Lim1, in the anterior visceral endoderm (AVE), and the failure of anterior embryonic development in Smad4 Co/Co;TTR-Cre embryos is accompanied by diminished expression of these genes. Consistent with this finding, SMAD4-deficient embryoid bodies showed impaired responsiveness to TGF-??induced gene expression and morphological changes. On the other hand, embryos carrying Cre-loxP mediated disruption of SMAD4 in the epiblasts exhibited relatively normal mesoderm and head-fold induction although they all displayed profound patterning defects in the later stages

Cuiling Li; Yi-ping Li; Xin-yuan Fu; Chu-xia Deng

22

A neural correlate of visceral emotional responses: evidence from fMRI of the thoracic spinal cord

  Biology and Medicine Websites

Summary: A neural correlate of visceral emotional responses: evidence from fMRI of the thoracic spinal cord Functional magnetic resonance imaging (fMRI) of thoracic spinal cord neurons was used to examine the neural preparedness. These images also enhanced activity in autonomic and sensory nuclei, thus providing a clear

Smith, Stephen D.

23

Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India

  University of Cambridge - Dspace

Summary: associated with susceptibility to cutaneous and mucocutaneous leishmaniasis in Brazil. Here we investigate the role of CXCR1/CXCR2 in visceral leishmaniasis (VL) in India. Methods Three single nucleotide polymorphisms (SNPs) (rs4674259, rs2234671, rs3138060...

Mehrotra, Sanjana; Fakiola, Michaela; Oommen, Joyce; Jamieson, Sarra E; Mishra, Anshuman; Sudarshan, Medhavi; Tiwary, Puja; Rani, Deepa SELVI; Thangaraj, Kumarasamy; Rai, Madhukar; Sundar, Shyam; Blackwell, Jenefer M
2011-12-15

24

Insecticide Susceptibility of Phlebotomus argentipes in Visceral Leishmaniasis Endemic Districts in India and

  CiteSeer

Summary: Objectives: To investigate the DDT and deltamethrin susceptibility of Phlebotomus argentipes, the vector of Leishmania donovani, responsible for visceral leishmaniasis (VL), in two countries (India and Nepal) with different histories of insecticide exposure. Methods: Standard WHO testing procedures were applied using 4 % DDT and 0.05 % deltamethrin impregnated papers. The effect of the physiological status (fed and unfed) of females on the outcome of the bioassays was assessed and the optimal time of exposure for deltamethrin was evaluated on a colony population. Field populations from both countries were tested. Results: Fed and unfed females responded in a similar way. For exposure time on field samples 60 min was adopted for both DDT and deltamethrin. In Bihar, knockdown and mortality with DDT was respectively 20 and 43%. In Nepal almost all sand flies were killed, except at the border with Bihar (mortality 62%). With 0.05 % deltamethrin, between 96 and 100 % of the sand flies were killed in both regions. Conclusions: Based on literature and present data 4 % DDT and 0.05 % deltamethrin seem to be acceptable discriminating concentrations to separate resistant from susceptible populations. Resistance to DDT was confirmed in Bihar and in a border village of Nepal, but the sand flies were still susceptible in villages more inside Nepal where only synthetic pyrethroids are used for indoor spraying. The low effectiveness of indoor spraying with DDT in Bihar to control VL can be partially explained

Diwakar Singh Dinesh; Murari Lal Das; Albert Picado; Lalita Roy; Suman Rijal; Shri Prakash; Pradeep Das; Marleen Boelaert; Marc Coosemans

25

Modelling Within-Host Immune Response to Visceral Helminthiasis and Malaria Co-infection with Prophylaxis

  CERN Preprints

Summary: In this paper, a co-infection of malaria and visceral helminthiasis with immune stimulation and impairment is studied. We have assumed that an individual gets malaria infection during invasion by helminths larvae. In absence of immune response, our results show that the antigens invade the blood system if the rate of red cell rupture per invading merozoite is greater than one. If fewer merozoites are released, the initial state is globally asymptotically stable. If more merozoites are released, there exists malaria-only endemic point. However, both antigens coexist if the mean infection burden is greater than one. In this case, there is a threshold value for drug action below which no recovery of host is expected. In presence of immune response, three equilibrium states exist. The initial invasion state, and secondly, the unstable state when the immune population has been triggered and the antigens have been eliminated. The third state represents the endemic state which is stable if the infection-induced rupt...

Nannyonga, Betty; Luboobi, L S
2011-01-01

26

Letters Visceral Leishmaniasis (Kala-Azar) Outbreak in Somali Refugees and Kenyan Shepherds, Kenya

  CiteSeer

Summary: To the Editor: A sharp increase in suspected visceral leishmaniasis (VL or kala-azar) cases was reported in April through May 2000 in three Kenyan refugee camps (Ifo, Dagahaley, and Hagadera). Located around Dadaab town in Northeastern Province, the three camps house an estimated 125,000 Somali refugees. VL outbreaks have been well documented in five distinct foci in Kenya (1,2), but until this outbreak, VL was only sporadically seen in the refugee camps or the province. We investigated a possible outbreak in the refugee sites. Before April 2000, doctors would request a formol-gel test (FGT) in case of suspected VL and treat an FGTpositive case with antimonials. Although the FGT is of uncertain validity, it is still used in district hospitals in Kenya for lack of alternative diagnostic tests. We considered a clinician’s request of an FGT as a proxy for “clinical VL suspicion ” and assessed the number of FGTs done from January 1999 to March 31, 2000. The first suspected VL patient was traced back to August 1999; this 40-year-old male Somali refugee had been ill for 8 months and sought treatment at Dagahaley camp. He responded well to antimonial treatment. From that date to April 1, 2000, an FGT was requested for five more patients; results were positive for two. Specific surveillance for VL was set up by the refugee health services in April 2000. Suspected patients or their caretakers were interviewed. Finger-prick blood was collected on filter paper and analyzed by direct agglutination test (DAT) (3). In August 2000, splenic aspirates were performed on eight patients for direct microscopic examination, and parasite culture was attempted for three specimens. In vitro isolation and gp63 polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) molecular typing was done at the Protozoology Unit of the Prince

unknown authors

27

Associações entre hipergamaglobulinemia E, alterações ultra-sonográficas do fígado e fatores de risco para Larva migrans visceral, e ELISA positivo para Toxocara canis em crianças e adolescentes: Estudo caso-controle.

  Open Access Theses and Dissertations

Summary: ??The lack case-control study a regard visceral larva migrans at children and adolescents encouraged accomplishment of retrospective, observational, case-control study was conducted between 2004 and… (more)

Elaine Alvarenga de Almeida Carvalho
2008-01-01

28

Research Article Visceral Abdominal and Subfascial Femoral Adipose Tissue Have Opposite Associations with Liver Fat in Overweight and Obese Premenopausal Caucasian Women

  CiteSeer

Summary: Copyright © 2011 Paulo M. Rocha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abdominal obesity has been associated with liver fat storage. However, the relationships between other body composition depots and metabolic syndrome features with hepatic fat are still unclear. We examined abdominal and thigh adipose tissue (AT) compartments associations with liver fat in 140 overweight and obese premenopausal Caucasian women. Blood lipids and, proinflammatory and atherothrombotic markers associations with hepatic fat were also analyzed. A larger visceral AT (VAT) was related with liver fat (P <0.05). Contrarily, thigh subfascial AT was inversely related to liver fat (P <0.05). Increased fasting insulin, triglycerides, PAI-1 concentrations, and a higher total-cholesterol/HDL-cholesterol ratio were also associated with hepatic fat, even after adjustment for VAT (P < 0.05). Thigh subfascial adiposity was inversely associated with liver fat, suggesting a potential preventive role against ectopic fat storage in overweight and obese women. These results reinforce the contribution of an abdominal obesity phenotype associated with a diabetogenic and atherothrombotic profile to liver lipotoxicity. 1.

Paulo M. Rocha; José T. Barata; Cláudia S. Minderico; Analiza M. Silva; Pedro J. Teixeira; Luís B. Sardinha

29

Emergency endovascular repair of ruptured visceral artery aneurysms

  University of Cambridge - Dspace

Summary: embolisation. Images showed unusual distorted anatomy with a large and small gastroduodenal artery and an inferior pancreatico duode- nal artery running parallel. There was extravasation of contrast from an aneurysm arising from the small duode- nal vessels... close to the superior mesenteric artery (SMA) (Figure 2). The feeding vessels were selectively embolised with coils from both SMA and celiac axis and stasis of flow was achieved (Figure 3, 4). The patient stayed in critical care unit for 5 days because...

Sadat, Umar; Noor, Nadim; Tang, Tjun Y; Varty, Kevin
2007-07-02

30

Systemic POMC Overexpression Increases Visceral Fat Accumulation in Mice.

  Open Access Theses and Dissertations

Summary: ??Proopiomelanocortin (POMC) is a polypeptide precursor with 241 amino acid residues which undergoes extensive post-translational modification to yield a range of smaller, biological active peptides… (more)

Tang, Chia-Hua
2011-01-01

31

Modelling and Simulation of Granuloma Formation in Visceral Leishmaniasis

  Computer Technologies and Information Sciences Websites

Summary: , York, UK Centre for Immunology and Infection, Hull York Medical School and Department of Biology understood. The importance of modelling in immunology is increasing particularly for dynamic processes Immune Systems (AIS) is widening to encompass the area of immunological modelling [1]. Along with [2

Timmis, Jon

32

SOMATIC AND VISCERAL GROWTH, AND ADIPOSITY IN THE PIG

  Computer Technologies and Information Sciences Websites

Summary: ; VARIATIONS ACCORDING TO THE KINDS OF OPERATIONS, TO THE SPECIFIC LOCATION ALONG THE INTESTINAL TRACT VISC�RALE, ET ADIPOSIT� CHEZ LE PORC AYR)�S R�SECTION PARTIELLE D'INTESTIN GR�LE. I. - VARIATIONS LI�ES AUX, d'une part les effets des divers actes opératoires mis en oeuvre lors de résection limitée d'intestin

Boyer, Edmond

33

Willpower and the Optimal Control of Visceral Urges

  CiteSeer

Summary: Common intuition and experimental psychology suggest that the ability to self-regulate, willpower, is a depletable resource. We investigate the behavior of an agent who optimally consumes a cake (or paycheck or workload) over time and who recognizes that restraining his consumption too much would exhaust his willpower and leave him unable to manage his consumption. Unlike prior models of self-control, a model with willpower depletion can explain the increasing consumption sequences observable in high frequency data (and corresponding laboratory …ndings), the apparent links between unrelated self-control behaviors, and the altered economic behavior following imposition of cognitive loads. At the same time, willpower depletion provides an alternative explanation for a taste for commitment, intertemporal preference reversals, and procrastination. Accounting for willpower depletion thus provides a more uni…ed theory of time preference.

Emre Ozdenoren; Stephen Salant; Dan Silverman
2006-01-01

34

Hyaluronan role in Xenopus laevis visceral skeleton morphogenesis.

  Open Access Theses and Dissertations

Summary: ??Hyaluronan (HA) is a crucial glycosaminoglycan of vertebrate extracellular matrix. In dynamic cellular systems, such as embryonic development, tissue regeneration and tumorigenesis, HA has been… (more)

CASINI, PAOLA
2008-01-01

35

Viscera(l) Views: Performing on the Brink of the Human.

  Open Access Theses and Dissertations

Summary: ??This dissertation is a performative exploration of experience within our technoscientific – that is, technologically and scientifically saturated – world. Drawing upon posthumanism and cyborg studies and… (more)

MacDonald, Shauna M.
2011-01-01

36

Original article Canine visceral leishmaniasis caused by Leishmania infantum in Senegal

  Biology and Medicine Websites

Summary: is a global concern and not simply a local problem. Indeed, in the context of global warming and the risk´decine, Montpellier, France Received 22 September 2009; accepted 3 September 2010 Abstract In the context of global warming and the risk of spreading arthropod-borne diseases, the emergence and reemergence of leishmaniasis


37

Visceral Leishmaniasis and Arsenic: An Ancient Poison Contributing to Antimonial Treatment Failure in the

  Biology and Medicine Websites

Summary: of the periodic table that share many struc- tural and chemical properties [7]. Anti- mony resistance, Banaras Hindu University, Varanasi, India, 3 College of Physical Sciences­Chemistry, Trace Element, Antwerp, Belgium Introduction Antimony and arsenic are elements that have a long history of use as poisons

Schnaufer, Achim

38

A Role of Visceral Adipose and Gastric Tissue in Inflammatory Conditions Associated With Metabolic Syndrome .

  Open Access Theses and Dissertations

Summary: ??Obesity has reached epidemic proportions globally. Obesity is accompanied by co-morbidities affecting multiple peripheral tissues. Obesity associated non-alcoholic fatty liver disease (NAFLD) is the leading… (more)

Mehta, Rohini
2013-01-01

39

Treatment of Obese Diabetic Mice With a Heme Oxygenase Inducer Reduces Visceral and Subcutaneous

  Biology and Medicine Websites

Summary: in a mouse and a rat model of diabetes, would ameliorate insulin resistance, obesity, and diabetes in the ob and in cultured MSCs and increased adiponectin levels in the culture media. Inhibition of HO activity decreased in the pathogenesis of insulin resistance, type 2 dia- betes, and its cardiovascular complications (1,2). Excessive

Abraham, Nader G.

40

Regionalisation of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder

  University of Cambridge - Dspace

Summary: Injected mRNA Stage Percentage of labelled conceptuses among the recovered nlsGFP E4.7-E5.0 50% nlsDsRed E4.7-E5.0 53% MmGFP E5.5 45% nlsDsRed E5.5 27% Stage Nb of blastocysts injected Nb of positive blastocysts transferred Nb... of the polar trophec- toderm from a squamous to a cuboidal epithelium (Addi- tional file 1A-B). In addition, pre-egg cylinder conceptuses may develop into early egg cylinder conceptuses as shown by the appearance of several layers of polar trophecto- derm cells...

Perea-Gomez, Aitana; Meilhac, Sigolene M; Piotrowska-Nitsche, Karolina; Gray, Dionne; Collignon, Jerome; Zernicka-Goetz, Magdalena
2007-08-16

41

Proximal visceral endoderm and extraembryonic ectoderm regulate the formation of primordial germ cell precursors

  University of Cambridge - Dspace

Summary: :gfp transgenic mouse lines were used to distinguish between PGC precursors and specified PGC, respectively. We observed that the VE regulates formation of an appropriate number of PGC precursors between E6.25–E7.25, but it is not essential...

Chuva de Sousa Lopes, Susana M; Hayashi, Katsuhiko; Surani, M Azim
2007-12-20

42

RESEARCH ARTICLE Open Access Ancient origin of somatic and visceral neurons

  Physics Websites

Summary: of the nervous system on a large phylogenetic scale is the identification of homologous neuronal types. Here, we to define homologous regions in the nervous system of dis- tant phyla. More recently, homology search has reference [6] for review). This approach provides a novel window on the complex- ity of ancestral nervous

Paris-Sud XI, Université de

43

Environmental concentration of nonylphenol alters the development of urogenital and visceral organs in avian model.

  Physics Websites

Summary: Montpellier 2; 34295 Montpellier (France). d 2iE foundation, International Institute for Water in various environmental compartments in concentrations ranging from ng to hundreds of ng/L in surface water et al., 2011; Mayer et al., 2007) and mg to hundreds of mg/kg in sewage sludge (González et al., 2010

Paris-Sud XI, Université de

44

Prevalência da infeção por Leishmania sp. em gatos residentes no Concelho de Cascais.

  Open Access Theses and Dissertations

Summary: ??A leishmaniose, causada pelo protozoário Leishmania infantum é uma doença parasitária transmitida por vetores flebotomíneos. Apesar de ser uma infeção que, tipicamente, afeta canídeos domésticos… (more)

Pinto, Pedro Miguel Faustino
2013-01-01

45

Universitt Ulm | 2010 2 Inhalt Content

  Computer Technologies and Information Sciences Websites

Summary: , Leishmaniose und Listeriose AIDS, Herpes, Leishmaniasis and Listeriosis ......... 17 Klimakiller Methan in Ethylen umgewandelt Climate Killer Methane Transformed into Ethylene ............18 Systembiologie Systems

Pfeifer, Holger

46

Atividade de constituintes micromoleculares de Renealmia alpinia (Rottb.) Maas (Zingiberaceae) sobre Leishmania (Leishmania) chagasi.

  Open Access Theses and Dissertations

Summary: ??As leishmanioses correspondem a um complexo de doenças tropicais causadas por protozoários pertencentes ao gênero Leishmania e encontram-se entre as seis endemias consideradas prioritárias no… (more)

Renata Machado Marchese
2009-01-01

47

Atividade de constituintes micromoleculares de Renealmia alpinia (Rottb.) Maas (Zingiberaceae) sobre Leishmania (Leishmania) chagasi.

  Open Access Theses and Dissertations

Summary: ??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, 2009. As leishmanioses correspondem a um complexo de doenças tropicais causadas por protozoários pertencentes ao gênero… (more)

Marchese, Renata Machado
2009-01-01

48

Gordura visceral, subcutânea e peri-renal: estudo de correlação com fatores de risco para aterotrombose utilizando a ultrasonografia.

  Open Access Theses and Dissertations

Summary: ??Background: The metabolic syndrome (MS) brings together a number of proatherogenic and pro-thrombotic risk-factors, which often culminate in premature death caused by atherosclerotic cardiovascular disease… (more)

Leonardo Silva Roever Borges
2008-01-01

49

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR2-Dependent Mechanism in Mice

  Biology and Medicine Websites

Summary: are not defined. We investigated the activation and function of cysteine cathepsins (Cat) in colitis. METHODS activated Cat-B, Cat-L, and Cat-S in colon and spinal cord, and Cat-S was preferentially secreted into the colonic lumen. Intralumi- nal Cat-S amplified visceromotor responses to colorectal distension and induced

Bogyo, Matthew

50

Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein- 4, and gamma-glutamyl transferase activity in overweight/obese humans

  University of California eScholarship Repository

Summary: binding protein 4, visceral fat, and the metabolic syndrome:visceral adi- posity, and this relationship is independent of hepatic fatfat content-independent association of the serum level of gamma- glutamyltransferase with visceral


2012-01-01

51

Développement d'outils chimiométriques pour l'étude des traitements antileishmaniens.

  Open Access Theses and Dissertations

Summary: ??Les leishmanioses sont des parasitoses en constante évolution, et l'accroissement d'apparitions de résistances vis-à-vis des traitements disponibles en fait une des préoccupations majeures des organismes… (more)

Imbert, Laurent
2012-01-01

52

The effect of active substances on mitochondrial function in Leishmania tarentolae.

  Open Access Theses and Dissertations

Summary: ??Leishmaniose ist eine Infektionserkrankung, die durch protozoische Parasiten der Gattung Leishmania hervorgerufen wird. Mitochondrien von Leishmanien werden als mögliches Target von Verbindungen, wie Tocopherol-derivaten, Chromanol-ähnlichen… (more)

Lackova, Alexandra
2014-01-01

53

Ocorrência de Leishmania spp. em cães, gatos e equinos no Estado de São Paulo.

  Open Access Theses and Dissertations

Summary: ??Cães, gatos e equinos domésticos podem ser importantes reservatórios de agentes infecciosos potencialmente zoonóticos, podendo-se destacar entre eles as leishmanioses. Por esse motivo, torna-se necessário… (more)

Graziella Ulbricht Benvenga
2013-01-01

54

Current Biology 20, 16, August 24, 2010 2010 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2010.06.059 Visceral-Locomotory Pistoning

  Engineering Websites

Summary: , Argonne, IL 60439, USA Summary Animals with an open coelom do not fully constrain internal tissues [1­3], and changes in tissue or organ position during body movements cannot be readily discerned from outside changes in the center of mass as a result of internal tissue movements [4, 5]. We used phase

Socha, Jake

55

Effects of Environmental Change on the Genetic Diversity and Distribution of Phlebotomus ariasi, a Vector of Visceral Leishmaniasis in Southwest Europe

  CiteSeer

Summary: DECLARATION BY CANDIDATE I have read and understood the School's definition of plagiarism and cheating given in the Research Degrees Handbook. I declare that this thesis is my own work, and that I have acknowledged all results and quotations from the published or unpublished work of other people. I have read and understood the School's definition and policy on the use of third parties (either paid or unpaid) who have contributed to the preparation of this thesis by providing copy editing and, or, proof reading services. I declare that no changes to the intellectual content or substance of this thesis were made as a result of this advice, and, that I have fully acknowledged all such contributions.

Shazia Sophie Mahamdallie; Full Shazia; Sophie Mahamdallie
2010-01-01

56

Avaliação ultrassonográfica da gordura visceral em participantes do Projeto Atividade Física na Vila ênfase na correlação com os fatores de risco cardiometabólicos.

  Open Access Theses and Dissertations

Summary: ??Abdominal obesity is closer to epidemic proportions in some countries with increasing prevalence among population around the world. Epidemiological studies have been confirmed that abdominal… (more)

Valeria Cataldo Gomes da Silva
2009-01-01

57

The IL-33/ST2 Axis Is Associated with Human Visceral Leishmaniasis and Suppresses Th1 Responses in the Livers of BALB/c Mice Infected

  Physics Websites

Summary: in the Livers of BALB/c Mice Infected with Leishmania donovani Octavie Rostan,a,b Jean-Pierre Gangneux-33 cells in a liver biopsy specimen from a patient. Similarly, in BALB/c mice experimentally infected cells and ST2 cells in the mouse liver. In ST2 / BALB/c mice, better control of the hepatic parasite

Paris-Sud XI, Université de

58

Research Article An Open-Label Pilot Study to Assess the Efficacy and Safety of Virgin Coconut Oil in Reducing Visceral Adiposity

  CiteSeer

Summary: Copyright © 2011 Kai Ming Liau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. This is an open-label pilot study on four weeks of virgin coconut oil (VCO) to investigate its efficacy in weight reduction and its safety of use in 20 obese but healthy Malay volunteers. Methodology. Efficacy was assessed by measuring weight and associated anthropometric parameters and lipid profile one week before and one week after VCO intake. Safety was assessed by comparing organ function tests one week before and one week after intake of VCO. Paired t-test was used to analyse any differences in all the measurable variables. Results. Only waist circumference (WC) was significantly reduced with a mean reduction of 2.86 cm

Kai Ming Liau; Yeong Yeh Lee; Chee Keong Chen; Aida Hanum; G. Rasool

59

A Software Tool for Volume Registration and Atlas-Based Segmentation of Human Fat-Water MRI Data in Longitudinal A. A. Joshi1

  Engineering Websites

Summary: and visceral adipose tissue depots as well as the degree of fat infiltration in the liver, pancreas, skeletal of subcutaneous and visceral fat depots [5-8]. In this work, we additionally focus on the organs (liver, pancreas

Southern California, University of

60

INTRODUCTION One central question in vertebrate development is how

  Biotechnology Websites

Summary: in the nervous system (the central and peripheral nervous system, CNS and PNS), where many hundreds of different pressure and visceral distension from the periphery to the central nervous system. Visceral sensory neurons

Sali, Andrej

61

Transgenerational Inheritance of Increased Fat Depot Size, Stem Cell Reprogramming, and Hepatic Steatosis Elicited by Prenatal Exposure to the Obesogen Tributyltin in Mice

  University of California eScholarship Repository

Summary: between hepatic/visceral fat and hepatic insulin resistanceLipids in the wrong place: visceral fat and nonalcoholicfat depot weights in F2 males were more marked than in F1 males, with substantial and significant increases in all visceral

Chamorro-García, Raquel; Sahu, Margaret; Abbey, Rachelle J; Laude, Jhyme; Pham, Nhieu; Blumberg, Bruce
2013-01-01

62

RESEARCH ARTICLE Open Access Analysis of lifestyle and metabolic predictors of

  Physics Websites

Summary: RESEARCH ARTICLE Open Access Analysis of lifestyle and metabolic predictors of visceral obesity Background: The aim of this study was to provide a framework for the analysis of visceral obesity and its lipids and adipocyte sizes have been considered as potential correlates of visceral obesity in women

Paris-Sud XI, Université de

63

SEASONAL CYCLES OF FAT AND GONAD VOLUME IN FIVE SPECIES OF NORTHERN CALIFORNIA ROCKFISH

  Environmental Sciences and Ecology Websites

Summary: SEASONAL CYCLES OF FAT AND GONAD VOLUME IN FIVE SPECIES OF NORTHERN CALIFORNIA ROCKFISH changes in visceral fat volume and gonad volume are compared in five species of rockfish from northern. In these species, visceral fat was deposited between spring and fall, at the same time as gametogenesis. Visceral


64

Microglia: a newly discovered role in visceral hypersensitivity? Carl Y. Saab1, Jing Wang2, Chunping Gu2, Kirsten N. Garner2, and Elie D. Al-Chaer2

  Biology and Medicine Websites

Summary: and after injection of FKN, minocycline or vehicle. Somatic thermal hyperalgesia was measured by latency. FKN also induced thermal hyperalgesia in control rats, consistent with previous reports; (2 60 min after injection. The anti-nociceptive effect of minocycline lasted for 180 min in rats with CI

Hayar, Abdallah

65

Effects of Bovine Respiratory Disease on Immune Response, Animal Performance, Nitrogen Balance, and Blood and Nutrient Flux Acros Total Splanchnic Tissues in Beef Steers.

  Open Access Theses and Dissertations

Summary: ??ctives were to evaluate the effects of bovine respiratory disease (BRD) on immune response, cattle performance, carcass characteristics, visceral organ mass, apparent nutrient digestibility, nutrient… (more)

Burciaga-Robles, Luis Octa
2009-01-01

66

Usability and Print Design.

  Open Access Theses and Dissertations

Summary: ??The print designer needs techniques to help align their perspective (functionality and appearance) to users’ perspectives (visceral, behavioral, and reflective; useful, usable, and desirable) of… (more)

Pollak, Jacob S.
2013-01-01

67

doi:10.1152/ajpendo.00077.2006 291:517-524, 2006. First published Apr 25, 2006;Am J Physiol Endocrinol Metab

  Biology and Medicine Websites

Summary: chronic hyperinsulinemia resulting from blunted hepatic clear- ance of insulin, visceral obesity in peripheral tissues was associated with significantly elevated intramuscular fat contents that may be second

Brand, Paul H.

68

Interaction of diet and adipose glucocorticoid action in metabolic syndrome.

  Open Access Theses and Dissertations

Summary: ??Metabolic syndrome, a combination of co-associated features including visceral obesity, dyslipidemia, hypertension, insulin resistance and increased risk of cardiovascular disease, has reached epidemic levels. Recent… (more)

Man, Tak Yung
2010-01-01

69

INFLAMMATION-INDUCED PLASTICITY OF MICTURITION REFLEX PATHWAYS.

  Open Access Theses and Dissertations

Summary: ??Although a seemingly basic and simple behavior, micturition necessitates precise integration and coordination of multiple divisions of the nervous system: visceral sensory, somatic motor, sympathetic,… (more)

Arms, Lauren
2011-01-01

70

Frequência do HLA classe I e II na pneumopatia intersticial e na hipertensão arterial pulmonar em pacientes com esclerose sistêmica.

  Open Access Theses and Dissertations

Summary: ??Introdução: A esclerose sistêmica (ES) é uma doença autoimune caracterizada por disfunção endotelial, vasculopatia obliterativa, fibrose cutânea e visceral. Trata-se de doença poligênica complexa que… (more)

Ana Paula Toledo Del Rio
2012-01-01

71

Efeito do consumo de suco de cranberry de baixa caloria sobre fatores de risco cardiovascular em indivíduos com síndrome metabólica.

  Open Access Theses and Dissertations

Summary: ??A Síndrome Metabólica (SM) é um transtorno patológico complexo que inclui resistência à insulina, hipertensão arterial, adiposidade visceral e dislipidemia, aumentando o risco de desenvolvimento… (more)

Tathiana Name Colado Simão
2012-01-01

72

Cranberry Flavonoid Supplementation and Biomarkers of Oxidative Stress in Subjects with Metabolic Syndrome.

  Open Access Theses and Dissertations

Summary: ??Metabolic syndrome (MeS), a collection of risk factors including dyslipidemia, hypertension, visceral adiposity, and hyperglycemia, is also a condition associated with increased oxidative stress and… (more)

Ortiz, Jennifer Paige
2010-01-01

73

Barostato rectal en el síndrome de intestino irritable .

  Open Access Theses and Dissertations

Summary: ??Background: Many patients with irritable bowel syndrome (IBS) have lowered sensory thresholds to rectal distention when compared to control subjects, a phenomenon called visceral hypersensitivity.… (more)

Defilippi Guerra, Claudia
2006-01-01

74

Irritable bowel syndrome. Pathophysiological and clinical aspects.

  Open Access Theses and Dissertations

Summary: ??Irritable bowel syndrome (IBS) is characterized by abdominal pain and/or discomfort related to abnormal bowel habits. Gastrointestinal (GI) motility disturbances, visceral hypersensitivity and psychological factors… (more)

Simrén, Magnus 1966-
2001-01-01

75

Interaction of diet and adipose glucocorticoid action in metabolic syndrome 

  Edinburgh, University of - Research Archive

Summary: Metabolic syndrome, a combination of co-associated features including visceral obesity, dyslipidemia, hypertension, insulin resistance and increased risk of cardiovascular disease, has reached epidemic levels. Recent ...

Man, Tak Yung
2010-01-01

76

37th Annual Northwestern

  Biology and Medicine Websites

Summary: , manage and treat vascular diseases, including but not limited to aneurysms, peripheral vascular disease the treatment options for visceral and renal artery aneurysmal and occlusive disease CONFERENCE LOCATION

Contractor, Anis

77

Efeitos da administração de metformina e pioglitazona sobre o metabolismo glicídico e a pressão arterial de ratos hipertensos tornados obesos pela injeção neonatal de glutamato monossódico.

  Open Access Theses and Dissertations

Summary: ??Introdução: Resistência insulínica (RI) e adiposidade visceral estão envolvidas na fisiopatogenia da Síndrome Metabólica (SM). Tratamento farmacológico da RI pode melhorar anormalidades glicêmicas e níveis… (more)

Carolina Baeta Neves Duarte Ferreira
2009-01-01

78

NATURAL HISTORY OF THE BAY SCALLOpl By JAMES S. GU'l'SELL, Ph. D.

  Environmental Sciences and Ecology Websites

Summary: _ Adductor muscle - - - ---- Circulatory system - - -- Nervous system and sense organs - .. - Urinogenital system _ Feeding _ Ciliary currents of the mantle, vis- ceral mass, etc _ Pigmentation of the visceral


79

ANATOMY AND PHYSIOLOGY OF THE WING-SHELL ATRINA RIGIDA

  Environmental Sciences and Ecology Websites

Summary: . Circulatory system " . Arterial system . Venous system " . Adductor muscles . Retractor muscles of the foot : ' . Visceral mass : . Foot and byssus . Kidney . Digestive tract ". ". " " . Nervous system ". : . " . Sense


80

Expression and regulation of monocyte chemoattractant protein-3 (MCP-3) in fibrosis.

  Open Access Theses and Dissertations

Summary: ??Systemic sclerosis is a multisystem connective tissue disease characterised by skin thickening and widespread, but variable, visceral fibrosis. The aetiopathogenesis is likely to involve immunological… (more)

Ong, V.H.
2009-01-01

81

LEISHMANIOSECUTANEE CHEZ LES MILITAIRES EN OPERATION EN GUYANE

  Physics Websites

Summary: : 05 94 33 88 75 e-mail : bzt.sebastien@wanadoo.fr La leishmaniose tégumentaire est une maladie'aspects variés, la maladie évolue en dépit de tous les traitements locaux mis en oeuvre. Les formes ulcéro, frontière est avec le Brésil, et assure des ssa-00399503,version1-29Oct2009 Manuscrit auteur, publié dans

Paris-Sud XI, Université de

82

Cell, Vol. 107, 387398, November 2, 2001, Copyright 2001 by Cell Press Jelly belly: A Drosophila LDL Receptor

  Engineering Websites

Summary: 10029 into groups of cells that will give rise to the heart, somatic muscle, visceral muscle, fat body al., 1994). Hh acts in combi-derm into visceral, somatic, and heart muscle precur- nation with dpp in the embryo (Campos-Ortega and Hartenstein, 1997).which somatic muscle precursors support the proper The 12

Quake, Stephen R.

83

Segmentation of male abdominal fat using MRI

  Mathematics Websites

Summary: Segmentation of male abdominal fat using MRI Peter Stanley Jørgensen Kongens Lyngby 2006 IMM is done into 3 classes: subcutaneous adipose tissue, visceral adipose tissue and other tissue. The MRI of adipose tissue into the subcutaneous adipose tissue and visceral adipose tissue classes is done using


84

V. Sinniger et al. EFFECT OF NOR-TRIMEBUTINE ON NEURONAL ACTIVATION INDUCED BY A

  Physics Websites

Summary: were counted for 1h as a marker of abdominal pain. c-fos expression was used as a marker of neuronal of trimebutine in the therapy of abdominal pain in the irritable bowel syndrome. Keywords c-fos ; colitis ; somato-visceral pain ; trimebutine ; visceral afferents. 2 inserm-00388054,version1-31Jul2009 #12;V

Paris-Sud XI, Université de

85

Bladder inflammation and hypogastric neurectomy influence uterine motility in the rat

  Biology and Medicine Websites

Summary: August 2001 Abstract How pathophysiology of one pelvic organ influences the physiology of another; Viscero­visceral interactions; Pelvic organs; Urinary tract Motility patterns of the urinary the hypogastric and pelvic nerves [3,7,12,20]. The existence of physiological viscero­visceral interac- tions

Berkley, Karen J.

86

Estrous changes in vaginal nociception in a rat model of endometriosis Angie M. Cason, Chad L. Samuelsen, and Karen J. Berkley*

  Biology and Medicine Websites

Summary: before and up to 4 months after autotransplantation of uterus (n 9) or fat (n 6) in abdominal sites: Estrogen; Fertility; Uterus; Referred pain; Visceral nociception; Dyspareunia; Psychophysics; Urogenital occur outside the uterus. Symptoms include reduced fertility and pelvic visceral pain, specifically

Berkley, Karen J.

87

Original Research Automatic Intra-Subject Registration-Based

  Engineering Websites

Summary: and linear regression of SAT and VAT volumes, organ volumes, and hepatic and pancreatic fat fractions (HFF, visceral, and organ (hepatic, pancreatic) fat has adverse effects on health and increases the risks of heart disease, diabetes, metabolic disorders, and cer- tain cancers (1,2). Subcutaneous and visceral

Southern California, University of

88

Characterization of abdominal adiposity and its relationship to adipokines and the adaptive immune response

  University of Kansas - KU ScholarWorks

Summary: to abdominal visceral adiposity. This dampening effect was observed across all categories of CD4+ T cell cytokines. Together, these results suggest that visceral fat mass in pregnancy has the potential to play a role in obesity-related pregnancy complications...

Ozias, Marlies
2013-12-31

89

ZOO 3713 COMPARATIVE VERTEBRATE ANATOMY Fall 2014 Syllabus Instructor : Mr. Frank T. Logiudice

  Environmental Sciences and Ecology Websites

Summary: Circulatory System 14 Nov 16 Circulatory System (cont.) 14 Nov 23 Urogenital System 15 Nov 31 Urogenital.) Lab Practical 2 is on 23 October Unit 3: Circulatory System and Visceral Organ Systems Topic -The circulatory system and visceral organ systems of the shark. mudpuppy and cat - Ch 3 Study Dates ­28 October


90

ZOO 3713 COMPARATIVE VERTEBRATE ANATOMY Fall 2013 Syllabus Instructor : Mr. Frank T. Logiudice

  Environmental Sciences and Ecology Websites

Summary: 20 Endocrine System 18 Oct 27 Digestive System 12 Nov 3 Respiratory System 13 Nov 10 Circulatory System 14 Nov 17 Circulatory System (cont.) 14 Nov 24 Urogenital System 15 Dec 1 Urogenital System (cont Unit 3: Circulatory System and Visceral Organ Systems Topic -The circulatory system and visceral organ


91

Sermon for Marsh Baldon, Road to Emmaus `Now when they heard this they were cut to the heart and said to Peter and the

  Mathematics Websites

Summary: is almost more visceral, they were pierced, their hearts were skewered or pierced by Peter's words. Surely hearts are pierced, too, when the eyes of the disciples at Emmaus are opened to the presence of the risen

Capdeboscq, Yves

92

The Role of Preadipocyte 11? Hydroxysteroid Dehydrogenase type 1 in Regional Fat Distribution 

  Edinburgh, University of - Research Archive

Summary: Glucocorticoid excess promotes visceral obesity, which is closely associated with morbidity and cardiometabolic disease. Similar features are found in the Metabolic Syndrome in the absence of elevated plasma cortisol. Whilst ...

De Sousa Peixoto, Ricardo
2007-01-01

93

Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Cte

  Environmental Sciences and Ecology Websites

Summary: ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous ethanol-fixed liver and other visceral tissues of 213 insectivorous bats (representing 13 genera


94

ISSUE NO.23 ISSN 1477-4860

  Biology and Medicine Websites

Summary: , kala-azar or visceral leishmaniasis (black water fever) continues to be referred as `the Assam Fever clings to it". Everywhere in the province European nostrils detected "noxious exhalations" and European

Rambaut, Andrew

95

Acta Tropica 100 (2006) 241245 Short communication

  Biology and Medicine Websites

Summary: species are differentiated by their fragment length. Indeed, L. donovani strains were characterized). species of the Leishmania donovani complex. This visceral form is characterized by hepatosplenomegaly,ecologyandpathology. L. infantum is anthropozoonotic with a dog reservoir, whereas


96

Robert L. Humphreys Jr. Honolulu Laboratory. Southwest Fisheries Science Center

  Environmental Sciences and Ecology Websites

Summary: - ences in macroparasites as well as hepatosomatic and visceral fat-so- matic indices. Of the two variants (the "fat," "in- termediate," and "lean" morphotypes.l were previously recognized and found 455 fatness in- dex


97

The role of vitamin D and adiponectin in ethnic-specific differences in body fat distribution and risk for cardiovascular disease.

  Open Access Theses and Dissertations

Summary: ??Background: Body fat distribution, in particular visceral adipose tissue (VAT), contributes to risk of cardiovascular disease (CVD). The Multicultural-Community Health Assessment Trial (M-CHAT) reported that… (more)

Sulistyoningrum, Dian
2012-01-01

98

Interventional radiology core skills simulation: mid term status of the CRaIVE projects EPOS: P-130

  Computer Technologies and Information Sciences Websites

Summary: contained in this pdf file is automatically generated from digital material submitted to e-Poster by third of radiologists trained in performance ofBackground. [Interventional . Visceral andradiology uses imaging to guide

Villard, Pierre-Frederic

99

Body mass, age, and reproductive influences on liver mass of white-tailed deer (Odocoileus virginianus)

  Environmental Sciences and Ecology Websites

Summary: body mass is controlled. Key words: Odocoileus virginianus, ruminant, scaling relationships, visceral. [Traduit par la Rédaction] Mots-clés : Odocoileus virginianus, ruminant, relation d'échelle, organe

Weckerly, Floyd "Butch" - Department of Biology, Texas State University

100

A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screening 

  Edinburgh, University of - Research Archive

Summary: Toxocara canis is an ascarid nematode parasite of canids. Larvae infect a wide range of accidental hosts including humans, in whom they are the aetiologic agent of visceral and ocular Larva migrans. The labile surface ...

Doedens, Andrew; Loukas, Alex; Maizels, Rick
2001-01-01

101

The Annals of Applied Statistics 2013, Vol. 7, No. 2, 669690

  Engineering Websites

Summary: of Geriatrics and Clinical Gerontology, NIA. The CIDR Visceral Adiposity Study includes a genome-wide association study funded as part of the Division of Aging Biology and the Division of Geriatrics and Clinical

Gordon, Geoffrey J.

102

Transforming SMEs into Successful Experience Stagers

  Engineering Websites

Summary: . Visceral design aims to appeal to the human senses impulsively and even subconsciously rather than. For example, if the dry cleaning service were to create a relaxing atmosphere using music and lighting

Karlsson, Brynjar

103

Machine Learning Approaches for Mood Classification of Songs toward Music Search Engine

  Computer Technologies and Information Sciences Websites

Summary: ]. The con- test concentrated on using audio information to detect mood of music. They use 5 mood clusters Wistful Humorous Fiery Confident Sweet Bittersweet Whimsical Visceral Boisterous Fun Autumnal Wry

Shirai, Kiyoaki

104

International Journal of Machine Consciousness World Scientific Publishing Company

  Computer Technologies and Information Sciences Websites

Summary: of the autobiographical self, the self-concept, the volitional or executive self, and the narrative self. This ext physical state of the organism [1999]. This proto-self receives neural and hormonal signals from visceral

Memphis, University of

105

On the Banks of the Karakoro

  University of Kansas - KU ScholarWorks

Summary: On the Banks of the Karakoro offers readers intimate details of life in Mauritania, a little-known West African country saddled by the Sahara and underdevelopment. Heartbreaking, visceral, honest, and hopeful, the account of my experience...

Miller, Jeremiah
2012-05-31

106

Talk about it Impaled computer

  Computer Technologies and Information Sciences Websites

Summary: but rather the powdery insides of an exploded stress doll. Colohan squeezed it to death while attempting a digital Christmas taps into something much deeper -- our reverence for, and visceral fear of, machines

Golbeck, Jennifer

107

DISPATCHES

  CiteSeer

Summary: Asymptomatic human visceral leishmaniasis was identified in Israel by using an enzyme-linked immunosorbent assay. Positive serum samples were more prevalent in visceral leishmaniasis–endemic (2.97%) compared to nonendemic (1.01%) regions (p=0.021). Parasite exposure was higher than expected, despite the small number of clinical cases, suggesting factors other than infection per se influence clinical outcome. Human visceral leishmaniasis (HVL), caused by the Leishmania donovani complex, is lethal if not promptly diagnosed and treated (1). Yet in the Mediterranean and Middle East, only a small percentage of infections progress to clinical disease (2,3). HVL in this region is primarily a disease of young children; however, its epidemiology is changing. In southern Europe, 50 % of new cases are in adults coinfected with HIV (4).

Irit Adini; Moshe Ephros; Jacopo Chen; Charles L. Jaffe

108

doi: 10.1098/rspb.2009.1662 , 915-922 first published online 18 November 20092772010Proc. R. Soc. B

  Biology and Medicine Websites

Summary: skull modifications. All modifications are of `soft morphology' (covered external nares and choanae. Aspects of its skull and visceral mor- phology are described and considered in terms of the possible life typhlonectid that has a highly modified skull and choanae covered by the oral mucosa, but has large, open

Wake, Marvalee H.

109

INTRODUCTION In Drosophila, the mesoderm is specified by genes that allot

  Biology and Medicine Websites

Summary: is retained in adult muscle progenitors set aside during embryogenesis but declines in embryonic muscle on the development of somatic muscles. Baylies and Bate (1996) also showed that Twi behaved like a `myogenic switch, in the mesoderm, Twi levels help determine cell-fate choices between somatic and visceral mesoderm. Vertebrate twi


110

INTRODUCTION During the course of embryogenesis the potential of cells

  Biology and Medicine Websites

Summary: INTRODUCTION During the course of embryogenesis the potential of cells becomes increasingly, visceral and somatic muscle, heart (dorsal) muscle, hemocytes, gonad-sheath cells (gonadal mesoderm, 197-205) and has been proposed to function in a cell-fate choice between fat cell and somatic gonadal

Hoshizaki, Deborah K.

111

Biochem. J. (1989) 262, 541-548 (Printed in Great Britain) Kinetic analysis of the interaction of alkyl glycosides

  Biology and Medicine Websites

Summary: substrates. INTRODUCTION Human visceral organs such as liver, spleen and kidney contain two prominent ,JBiochem. J. (1989) 262, 541-548 (Printed in Great Britain) Kinetic analysis of the interaction of alkyl glycosides with two human fl-glucosidases Venkatakrishnan GOPALAN,* Lydia B. DANIELS,* Robert H

Gopalan, Venkat

112

Endocrinology 2010 151:5157-5164 originally published online Sep 22, 2010; , doi: 10.1210/en.2010-0176 Sonia M. Najjar

  Biology and Medicine Websites

Summary: 48109 Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including-capacityrunners(LCR)]viaselectionbasedontread- mill running distance to exhaustion exhibit features of the metabolic syndrome, including visceral. Koch, Steven L. Britton, Ulrik Wisløff, Abraham D. Lee, and Sonia M. Najjar Center for Diabetes

Toledo, University of

113

Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in Rats with Low Aerobic Capacity

  Biology and Medicine Websites

Summary: selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia running distance to exhaustion exhibit features of the metabolic syndrome, including visceral obesity. Lee, and Sonia M. Najjar Center for Diabetes and Endocrine Research (T.A.B., S.K.R., M.K., S.J.L., P

Toledo, University of

114

CHAPTER VII Anatomy of the gllls__________________________________________________ 121

  Environmental Sciences and Ecology Websites

Summary: _________________________________ 139 Metallic Ions __ _ 139 Hydrogen lons______ __ __ 140 Various drugs_ _ _ 140 Inhibition of ciliary. This primitive type, present in the order Protobranchia FISHERY BULLETIN: VOLUME 64, CHAPTER VII (fig. 115, A with the mantle and visceral mass. These were formerly designated as a separate order of Pseudolamellibranchia


115

Nodal signalling is involved in leftright asymmetry in Cristina Grande1,2,3

  Environmental Sciences and Ecology Websites

Summary: LETTERS Nodal signalling is involved in left­right asymmetry in snails Cristina Grande1,2,3 & Nipam a randomization of the left­right asymmetry of visceral organs3,4 . Orthologues of nodal have also been described are expressed on the right side of the embryo in the dextral (right-handed) species Lottia gigantea

Patel, Nipam H.

116

Algebraic decomposition of fat and water in MRI Mathews Jacob, Member, IEEE, and Bradley P. Sutton, Member, IEEE

  Biology and Medicine Websites

Summary: several applications in medical imaging, including fat suppression and quantification of visceral fat. We1 Algebraic decomposition of fat and water in MRI Mathews Jacob, Member, IEEE, and Bradley P. Sutton, Member, IEEE Abstract-- The decomposition of MRI data to generate water and fat images has

Jacob, Mathews

117

Knowledge-based Quantification of Pericardial Fat in Non-Contrast CT Data

  Computer Technologies and Information Sciences Websites

Summary: fat has shown excellent correlation with abdominal visceral fat,3 a known cardiovascular risk factorKnowledge-based Quantification of Pericardial Fat in Non-Contrast CT Data Raja YalamanchiliaDepartment of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA ABSTRACT Recent studies show that pericardial fat

Kakadiaris, Ioannis

118

Antivir Ther . Author manuscript Immune deficiency could be an early risk factor for altered insulin

  Engineering Websites

Summary: (OGTT), adipokines, subcutaneous and visceral fat surfaces (SAT and VAT, assessed by computed tomography immunovirological status, inflammatory markers, insulin resistance and fat distribution have not been studied) and the body fat distribution based on dual-energy X-ray absorptiometry (DEXA). Results Median age was 36 years


119

Atherosclerosis 209 (2010) 136141 Contents lists available at ScienceDirect

  Biology and Medicine Websites

Summary: stratification. We extended previously developed quantitation of thoracic fat volume (TFV) from non measured from non-contrast CT for 201 patients. In 105 patients, abdominal visceral fat area (VFA) was measured from an additional single-slice CT. In 26 patients, images were quantified by two readers

Kakadiaris, Ioannis

120

Godzilla Geometry page-1 Godzilla Geometry a.k.a. the Cosmic Distance Ladder

  Physics Websites

Summary: activities can offer students a visceral feel for how the cosmological distance ladder works. This physical activities that took advantage of the observatory's resources. After all the students had cycled through Kavli Institute for Cosmological Physics University of Chicago 5640 South Ellis Ave Chicago, IL 60637 e

Collar, Juan I.

121

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research

  Biology and Medicine Websites

Summary: 's personal copy Mini-review The role of interoception and alliesthesia in addiction Martin P. Paulus a August 2009 Keywords: Addiction Insula Interoception Alliesthesia Reward This review presents a novel conceptualization of addiction, integrating the concepts of interoception (i.e., the CNS representation of visceral

Squire, Larry R.

122

ARTICLE IN PRESS Purinergic P2 receptors as targets for novel analgesics

  Biology and Medicine Websites

Summary: ) injections producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype, which, and ureter that mediate the initiation of pain. Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP released from epithelial cells lining the bladder, ureter, and intestine during

Burnstock, Geoffrey

123

Purinergic P2 receptors as targets for novel analgesics Geoffrey Burnstock *

  Biology and Medicine Websites

Summary: pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype, which was shown the initiation of pain. Purinergic mechanosensory transduction has been proposed for visceral pain, where ATP to the pain centers in the brain as well as initiating local reflexes. P1, P2X, and P2Y receptors also appear

Burnstock, Geoffrey

124

(WHR) and fasting triglyceridemia status on postabsorptive lipid metabolism.

  Physics Websites

Summary: resistance. Dual energy X-ray absorptiometry (DEXA) and anthropometric measure- ments combination with intra-abdominal visceral fat excess by simple anthropometric parame- ters (waist measurement: WM anthropometric measurements were collected at the same time by a unique inves- tigator. Multiple data on regional

Paris-Sud XI, Université de

125

The organizer factors Chordin and Noggin are required for mouse

  Biology and Medicine Websites

Summary: , Berkeley, California 94720-3204, USA k Samuel Lunenfeld Research Institute, Mount Sinai Hospital .............................................................................................................................................. In mice, there is evidence suggesting that the development of head and trunk structures is organized by distinctly separated cell populations1,2 . The head organizer is located in the anterior visceral endoderm

De Robertis, Eddy M.

126

Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK

  Biology and Medicine Websites

Summary: , cancer, dry eye, bladder hyperactivity, erectile dysfunction, osteoporosis, diabetes, gut motility.--Thrombosis.--Visceral pain.-- Cancer.--Osteoporosis.--Peripheral vascular disease.--Cystic fibrosis.--Parkinson's disease supraventricular, cáncer, ojo seco, hiperactividad de vejiga, disfunción eréctil, osteoporosis, diabetes, motilidad

Burnstock, Geoffrey

127

BioMed Central Page 1 of 16

  Physics Websites

Summary: AccessResearch article Regionalisation of the mouse visceral endoderm as the blastocyst transforms-embryonic region of the egg cylinder forms from the blastocyst. Our analysis suggests a new model for the formation into single surface cells of the inner cell mass of the blastocyst and analysed the distribution of labelled

Paris-Sud XI, Université de

128

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation

  Biology and Medicine Websites

Summary: Review Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, as well as ATP and GTP, most likely appeared in the prebiotic period, with adenine derivatives being

Burnstock, Geoffrey

129

Preliminary study on the use of neural arches in the age determination of

  Environmental Sciences and Ecology Websites

Summary: 861 Preliminary study on the use of neural arches in the age determination of bluntnose sixgill for estimated size-at-maturity for females enhancing and examining vertebral is 396 cm (Ebert, 1992), although the use of in chondrocranium, jaws, visceral neural arches as an alternate body arches, fin cartilage


130

Twelfth Night Zoe Golub-Sass '16

  Chemistry Websites

Summary: provoking and visceral. It is, in essence, a celebration of the arts--music, poetry Festival and in leading roles in both Bat Boy the Musical and Seussical the Musical with the UTC. She's volunteered with Shakespeare Santa Cruz for numerous

Snider, Barry B.

131

Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese subjects

  Computer Technologies and Information Sciences Websites

Summary: 1 Impaired alternative macrophage differentiation of peripheral blood mononuclear cells from obese differentiation and obesity Address correspondence to: Bart Staels Inserm UR 1011, Institut Pasteur de Lille 1 in "Diab Vasc Dis Res 2012;9(3):189-95" DOI : 10.1177/1479164111430242 #12;2 ABSTRACT Visceral obesity

Boyer, Edmond

132

New CT imaging method for adipose tissue analysis in mouse model of obesity SYLVAIN ORDUREAU

  Physics Websites

Summary: New CT imaging method for adipose tissue analysis in mouse model of obesity SYLVAIN ORDUREAU 3 and for quantification of visceral and subcutaneous fat. Equivalent methods adapted to murine models of obesity are still to obese mice [-206;-32]. The resulting computed volumes of fat tissue were respectively 4756 and 5978 mm3

Paris-Sud XI, Université de

133

Diab Vasc Dis Res . Author manuscript Impaired alternative macrophage differentiation of peripheral blood

  Computer Technologies and Information Sciences Websites

Summary: of peripheral blood mononuclear cells from obese subjects Gael Bories 1 , Robert Caiazzo 2 3 , Bruno Derudas 1 Staels Abstract Visceral obesity, a chronic, low-grade inflammatory is suggested to influence the metabolic complications of obesity." " These macrophages derive primarily from

Boyer, Edmond

134

Corresponding author: Philippe Lefebvre, Facult de Mdecine de Lille-Ple Recherche; INSERM U545-Btiment J&K; Boulevard du Professeur Leclerc ;

  Computer Technologies and Information Sciences Websites

Summary: REPROGRAMS PEROXISOME PROLIFERATOR- ACTIVATED RECEPTOR g TRANSCRIPTIONAL ACTIVITY IN OBESITY Bruno Lefebvre1 #12;-2- SUMMARY The chronic, low grade inflammation occurring in obese patients, which predisposes report that the PPAR( signaling pathway operates differently in visceral WAT from lean mice vs. obese

Boyer, Edmond

135

Muscle type-specific expression of Zasp52 isoforms in Drosophila Anja Katzemich, Jenny Yanyan Long, Klodiana Jani, Byeo Ri Lee, Frieder Schck

  Biology and Medicine Websites

Summary: : Zasp Drosophila PDZ-LIM domain protein Alp/Enigma family Alternative splicing Muscle attachment Z diskMuscle type-specific expression of Zasp52 isoforms in Drosophila Anja Katzemich, Jenny Yanyan Long assembly Myofibril assembly Heart muscle Visceral muscle Somatic muscle a b s t r a c t Zasp52 is a member

Schoeck, Frieder

136

Hindawi Publishing Corporation Experimental Diabetes Research

  Biotechnology Websites

Summary: state, and hypertension in increasing an individual's risk of developing type II diabetes mellitus, excess visceral adipose deposition, hyperglycaemia, glucose and insulin intolerances, hypertension such as an excessive caloric intake are indi- cated as important factors in initiating obesity and the as- sociated

Hammock, Bruce D.

137

Navigation methods that use traditional orthogonal views are limited since three-dimensional information

  Computer Technologies and Information Sciences Websites

Summary: and residents with an image-guided system for pedicle screw placement that used standard orthographic navigation and a 3D view method. The placement of pedicle screws is a technically demanding procedure owing that is in close proximity to sensitive neural, vascular and visceral elements. As such, we chose pedicle screw

Stewart, James

138

State of the mind: Emotions, body feelings, and thoughts share distributed neural Suzanne Oosterwijk, Kristen A. Lindquist, Eric Anderson, Rebecca Dautoff, Yoshiya Moriguchi,

  Biology and Medicine Websites

Summary: 'm going to ask you to create today are body feelings. A bodily sensation consists of internal, visceral. Sometimes you have very specific feelings in your organs such as a sense of your stomach muscles air, the feeling of your heart fluttering in your chest, and so on. Sometimes you have more vague

Barrett, Lisa Feldman

139

Columbia University Program in Physical Therapy Alumni News

  Biology and Medicine Websites

Summary: to work with the performing arts community and apply her visceral and kinesthetic understanding of danceColumbia University Program in Physical Therapy Alumni News SHANNON NARASIMHAN, DPT Shannon Narasimhan, CUDPT 2012 Katy Perry: The Prismatic World Tour Shannon is currently a Neuro Tour Physical

Grishok, Alla

140

Sexual size dimorphism in spiders: patterns and processes

  Environmental Sciences and Ecology Websites

Summary: - soma is the spider's abdomen containing most of the visceral organs, the gonads, and the silk glands the abdomen are pumped into the anterior regions of the body to expand the new and still soft cuticle (Foelix) and are therefore very useful and easy to measure for estimating a spider's size. On the other hand, the abdomen

Foellmer, Matthias

141

Symposium Clinical Research Priority Program Non-resectable liver tumors

  Plasma Physics and Fusion Websites

Summary: 1st Symposium ­ Clinical Research Priority Program Non-resectable liver tumors ­ from palliation Department of Visceral and Transplant Surgery LAB D 34 Phone 044 255 20 71 Venue UniversityHospital Zürich Research Priority Program) on liver tumors. Treatment of complex liver diseases is only possible

Zürich, Universität

142

Prostaglandins & other Lipid Mediators 104105 (2013) 4248 Contents lists available at SciVerse ScienceDirect

  Biotechnology Websites

Summary: hydrolase on glucose homeostasis and islet damage in a streptozotocin-induced diabetic mouse model Lingdan of chemical- induced diabetes. STZ increased daily water intake and decreased visceral (spleen and pancreas-induced diabetes. © 2012 Elsevier Inc. All rights reserved. 1. Introduction The Centers for Disease Control

Hammock, Bruce D.

143

Reactive oxygen species deglycosilate glomerular a-dystroglycan

  Biology and Medicine Websites

Summary: visceral epithelial cells, which cover the outside of the glomerular basement mem- brane (GBM). Together with the GBM and the fenestrated glomerular endothelial cells they form the capillary filter, which allows size, besides the a3b1-integrin, a major connecting molecule between the podocyte and the GBM.1 Furthermore

Campbell, Kevin P.

144

musischeszentrum www.uni-ulm.de/einrichtungen/muz

  Computer Technologies and Information Sciences Websites

Summary: ) · Gabriel Pierné, Konzert für Harfe und Orchester · Ludwig van Beethoven, Sinfonie Nr. 6 ,,Pastorale in the 21st century, now and before 3. Lecture on the Lateral and visceral on Language and art 4. MUZ Tage

Ulm, Universität

145

38th Annual Northwestern

  Biology and Medicine Websites

Summary: detect, diagnose, manage and treat vascular diseases, including but not limited to aneurysms, peripheral the limitations of eVAr · Demonstrate the treatment options for visceral and renal artery aneurysmal and occlusive about the latest developments in treatment of thoracoabdominal aortic aneurysm disease · evaluate new

Chisholm, Rex L.

146

Vaginal hyperalgesia in a rat model of endometriosis Karen J. Berkley*, Angie Cason, Heather Jacobs,

  Biology and Medicine Websites

Summary: sham) was induced by autotransplantation of small pieces of uterus (or fat) on mesenteric cascade rights reserved. Keywords: Uterus; Referred pain; Fertility; Pelvic organ; Visceral pain Endometriosis the uterus, usually in the abdominal/pelvic cavity. Its main symptoms include reduced fertility, severe dysme

Berkley, Karen J.

147

Chapter 2: Regression analysis This chapter introduces a method of analyzing the relationship between one quantitative

  Mathematics Websites

Summary: and body-size dependency of hematology in highly trained athletes. Medicine and Science in Sports and linear, though the relationship differs by gender. Given the same percent body fat, women tend to have less subcutaneous fat than men. Presumably, women have somewhat more visceral fat than men when percent

Bardsley, John

148

Dterminisme neuro humoral de l'adaptation de l'intestin rsiduel aprs entrectomie

  Physics Websites

Summary: factors and the role of the nervous system in the adaptation processes. Evidence for blood-borne factors system is established. Visceral sensitivity conveyed to the central nervous system through the vagal under study. The paper then reviews extrinsic influences, i.e. nervous effects as shown by denervation

Paris-Sud XI, Université de

149

Intermuscular tendons are essential for the development of vertebrate stomach

  Physics Websites

Summary: coordination of the enteric nervous system and the visceral smooth muscle cells (SMC), and defective The gastrointestinal (GI) tract is a remarkably complex, three-dimensional, specialized system derived from a simple layer), endoderm (which forms the epithelial lining), and ectoderm (which includes the enteric nervous

Paris-Sud XI, Université de

150

New Species of Lipinia (Squamata: Scincidae) from Borneo, Revealed by Molecular and Morphological Data

  Environmental Sciences and Ecology Websites

Summary: toe IV 16­17; supralabials 6; infralabials 6­7; subcaudals 68­74; and dorsum tan brown with dark gray-brown color pattern typically comprising a pale (rarely dark) middorsal stripe at least anteriorly; visceral differs in coloration and its preference for terrestrial habitats. In addition, analysis of DNA sequence

Austin, Christopher C.

151

Protostomia: Lophotrochozoa: Mollusca Protostomia: Lophotrochozoa: Mollusca

  Environmental Sciences and Ecology Websites

Summary: carbonate shells ­ lost or reduced in some · Heart and open circulatory system #12;Mollusca Protostomia · Calcium carbonate shells ­ lost or reduced in some · Heart and open circulatory system ­ hemocoel #12 or reduced in some · Heart and open circulatory system ­ hemocoel · 3 main body parts: foot, visceral mass


152

Acta Tropica 97 (2006) 364369 Refinement of techniques for the propagation of Leishmania

  Biology and Medicine Websites

Summary: development against visceral leishmaniasis. Here we report refinements to the hamster model of infection Health Organisation reports over 12 million cases of all forms of leishmaniasis worldwide with 500 is by no means the perfect animal model. Firstly, due to their comparatively high body mass, they require larger

Schnaufer, Achim

153

Acknowledgment I would like to thank my two advisors, Gene Gindi and George Zubal, for their

  Biology and Medicine Websites

Summary: tattooing. They have to open you up. They use an ink that contains a radioactive isotope so that the tattoo: : : I have it tattooed on my heart. And I don't mean on the skin of my chest over my heart. I mean tattooed on the organ itself. It's illegal in the States--I had to go to Mexico. It's called visceral

Duncan, James S.

154

The interaction of antinociceptive effects of morphine and GABA receptor agonists within the rat spinal cord

  CiteSeer

Summary: Previous reports indicate that there may be an interaction between ?-aminobutyric acid receptors and opioid receptors systems within the spinal cord, the antinociceptive effects of which have not been elucidated. We examined the effects of intrathecally coadministered morphine and muscimol or baclofen on somatic and visceral antinociception in rats. The tail flick (TF) test and colorectal distension (CD) test were used to assess somatic and visceral antinociceptive effects, respectively. Motor function was also assessed. The measurements were performed for 180 min after the intrathecal administration of morphine (0.1–10 ?g), muscimol (0.2–10 ?g), baclofen (0.03–1 ?g), combination of morphine and muscimol or baclofen, or saline. Morphine, muscimol, or baclofen increased both TF latency and

Kaoru Hara; Shinichi Sakura Md; Yoshihiro Kosaka
1999-01-01

155

A novel cadherin cell adhesion molecule: its expression pattern associated with implantation and organogenesis of mouse embryos

  CiteSeer

Summary: Abstract. The Ca2+-dependent cell adhesion molecules, termed cadherins, were previously divided into two subclasses, E- and N-types, with different adhesive specificity. In this study, we identified a novel class of cadherin, termed P-cadherin, using a visceral endoderm cell line PSA5-E. This cadherin was a l18,000-D glycoprotein and distinct from E- and N-cadherins in immunological specificity and molecular mass. In accord with these findings, cells with P-cadherin did not cross-adhere with cells with E-cadherin. P-Cadherin first appeared in developing mouse embryos in the extraembryonic ectoderm and the visceral endoderm at the egg cylinder stage and later was expressed in various tissues. The placenta and the uterine decidua most abundantly expressed

Akinao Nose; Masatoshi Takeichi
1986-01-01

156

An investigation of the Schwartz Cognitive-Somatic Anxiety Questionnaire

  Texas A&M University - TxSpace

Summary: to other visceral and glandular processes (Kotses, Rapaport & Glaus, 1978; Shapiro & Surwit, 1976), and in extending the application of these learning principles to stress-related disorders such as asthma (Kotses, Glaus, Bricel, Edwards, & Crawford..., the muscular system, and/or the respiratory system. Some of the current stress-related behaviors in the literature are: anxiety related behaviors, asthma, cardiac arrhythmias, headaches, hypertension, muscular rehabilitation, muscular tension, pain, sexual...

Goldston, James Donald
2012-06-07

157

Urine Protein Analysis and Correlation of Urinary Biomarkers with Renal Disease Progression in Dogs with X-Linked Hereditary Nephropathy

  Texas A&M University - TxSpace

Summary: The glomerular capillary wall is composed of three major structural components: the fenestrated capillary endothelium, the glomerular basement membrane (GBM) and visceral epithelial cells called podocytes (Figure 1). These components all closely interact... preventing passage of albumin or in functionally altering the other barrier components through signaling mechanisms.32 Glomerular basement membrane The glomerular basement membrane (GBM) is produced by both podocytes and endothelial cells.37 The main...

Nabity, Mary B.
2012-02-14

158

Key Words: Osler-weber-Rendu disease, Cerebral Infarction

  CiteSeer

Summary: Osler-Weber-Rendu disease is characterized by epistaxis, cutaneous telangiectasia, and visceral arteriovenous malfor-mations (AVMs). A 65-year-old male with recurrent epistaxis, old infarction and recent multiple rib fractures caused by a bicycle accident had middle cerebral thromboembolic infarctions when he stopped taking clopidogrel due to massive epistaxis and hemopneumothorax. On examinations, there was no focal cerebral stenosis, but there were telangiectasia, pulmonary and hepatic AVMs. A suspicious Osler-Weber-Rendu disease patient should be evaluated by proper screening and regular follow-up to minimize serious sequelae such as thromboembolic stroke.

Jong Hee Shon; Hui Chul Choi
2007-01-01

159

Sida rhomboidea. Roxb Leaf Extract Down-Regulates Expression of PPAR?2 and Leptin Genes in High Fat Diet Fed C57BL/6J Mice and Retards in Vitro 3T3L1 Pre-Adipocyte Differentiation

  CiteSeer

Summary: Abstract: Sida rhomboidea. Roxb leaf extract (SRLE) is being used by the populace of North-East India to alleviate symptoms of diabetes and obesity. We have previously reported its hypolipidemic and anti-diabetic properties. In this study, we report the effect of SRLE on (i) in vivo modulation of genes controlling high fat diet (HFD) induced obesity and (ii) in vitro 3T3L1 pre-adipocyte differentiation and leptin release. Supplementation with SRLE significantly prevented HFD induced increment in bodyweight, plasma lipids and leptin, visceral adiposity and adipocyte hypertrophy. Also, SRLE supplementation reduced food intake, down regulated PPAR?2, SREBP1c, FAS and LEP expressions and up-regulated CPT-1 in epididymal adipose tissue compared to obese mice. In vitro adipogenesis of 3T3L1 pre-adipocytes was significantly retarded in the presence of SRLE extract. Also decreased triglyceride accumulation, leptin release and glyceraldehyde-3-Phosphate dehydrogenase activity along with higher glycerol release without significant alteration of viability of 3T3L1 pre-adipocytes, was recorded. Our findings suggest that prevention of HFD induced visceral adiposity is primarily by down regulation of PPAR?2 and leptin gene expression coupled with attenuation of food intake in C57BL/6J mice.

Menaka C. Thounaojam; Ravirajsinh N. Jadeja; Umed V. Ramani; Ranjitsinh V. Devkar; A. V. Ramach
2011-01-01

160

PERSPECTIVE Role of the Domestic Chicken (Gallus gallus) in the

  CiteSeer

Summary: Zoonotic visceral leishmaniasis (ZVL) is a serious public health problem in several Brazilian cities. Although the proximity of chicken houses is often cited as a risk factor in studies of urban ZVL, the role chickens play in the epidemiology of the disease has not been defined. Chickens attract both male and female sand flies (Lutzomyia longipalpis) but are unable to sustain Leishmania infections, and their presence may exert a zooprophylactic effect. We discuss environmental, physiologic, socioeconomic, and cultural factors related to chicken raising that could influence Le. infantum transmission in Brazilian cities and evaluate whether this practice significantly affects the risk of acquiring ZVL. D uring the last 20 years, zoonotic visceral leishmaniasis (ZVL) due to Leishmania (Leishmania) infantum has become a serious public health problem in several Brazilian cities (1). The pathogen is transmitted by the bite of the phlebotomine sand fly Lutzomyia longipalpis (Lutz & Neiva 1912), and although humans can be infected, they are believed to be “dead-end ” hosts; domestic dogs are the main reservoirs

Epidemiology Of Urban Visceral; Marcos Horácio Pereira

161

AJNR Am J Neuroradiol 20:1920–1924, November/December 1999 Central Processing of Rectal Pain: A Functional MR Imaging Study

  CiteSeer

Summary: BACKGROUND AND PURPOSE: Although the central processing of somatic pain has been dealt with in numerous brain imaging studies, the neural correlates of visceral pain have received much more limited attention. Our goal was to assess the feasibility of detecting brain activation patterns induced by rectal pain by means of functional MR imaging. We hypothesized that the cerebral processing of rectal pain would exhibit strong similarities with the central processing of somatic pain. METHODS: Functional MR imaging data were obtained from eight healthy subjects. A block paradigm was applied. Rectal pain was induced by inflating a latex balloon catheter that had been inserted into the rectum. Functional responses were established by means of cross-correlation analysis. RESULTS: Activation was detected within the anterior cingulate gyrus, the prefrontal cortex, the insular cortex, the sensory-motor cortex, the inferior parietal lobule, the posterior cingulate gyrus, and the visual cortex. CONCLUSION: Functional MR imaging of visceral pain is feasible in healthy subjects. The activation patterns observed in this study support the hypothesis that the cerebral processing

Monica V. Baciu; Bruno L. Bonaz; Emmanuel Papillon; Richard A. Bost; Jean-françois Le Bas; Jacques Fournet; Christoph M. Segebarth
1999-01-01

162

RECONSTRUCTIVE VASCULAR SURGERY FOR INTESTINAL ANGINA

  CiteSeer

Summary: THE disastrous consequences of infarction of the bowel are well documented. In an accumulated series of 274 patients from seven major centres up to 1975 the mortality averaged 95 per cent. ' Baccelli2 in 1918 first described the syndrome of chronic intestinal ischaemia manifested by post-prandial pain. It was not until 1933 that Connor3 and Dunphy4 linked intestinal angina to chronic visceral artery occlusion and eventual bowel infarction. In 1957, Mickelson5 suggested a possible surgical approach in the management of atherosclerotic occlusion of the visceral arteries, and in the following year this proved to be successful.6 Intestinal angina, as a syndrome, was slow to be recognised and by 1972 only 92 cases had been reported.7 Since then, increasing numbers of cases have been reported, the largest series from the Mayo Clinic incorporating 56 patients treated over a period of 20 years.8 We present two cases of intestinal angina and discuss their diagnosis and management. CASE REPORTS Case I (N.H.). This 55-year-old woman gave a 6-month history of regular

C. F. Harvey; A. A. B. Barros D' sa

163

Available online:

  CiteSeer

Summary: Diabetes mellitus has now assumed epidemic proportions in many countries of the world. With the present population of 19.4 million diabetics, and approximately 60 million by the year 2025, India would rank first in its share of the global burden of diabetes. The autonomic nervous system (ANS) is an extensive neural network whose main role is to regulate the milieu intérieur by controlling homeostasis and visceral functions. Diabetes mellitus is most commonly associated with autonomic dysfunction, in persons with diabetes; prolonged hyperglycemia leads to degradation of the microvasculature, leading to a specific form of autonomic dysfunction firmed “Diabetes Autonomic Neuropathy”. The diagnosis of Autonomic Neuropathy is often difficult to establish in individuals, since clinical symptoms generally appear late in the course of the disease and may be nonspecific, Early detection of Autonomic Neuropathy would suggest the need for an aggressive approach in the management of diabetes mellitus with the help of simple autonomic function test.

Ekambaram Gnanadesigan; Balumahendran K; Gnanagurudasan E
2013-01-01

164

Microwave Bragg-scattering zone-axis-pattern analysis

  CERN Preprints

Summary: Louis deBroglie's connection between momentum and spatial-frequency vectors is perhaps most viscerally-experienced via the real-time access that electron-diffraction provides to transverse slices of a crystal's reciprocal lattice. The classic introductory (and/or advanced) physics lab-experiment on microwave Bragg-scattering can with a bit of re-arrangement also give students access to "zone-axis-pattern" slices through the 3D spatial-frequency (i.e. reciprocal) lattice of a ball-bearing crystal. In this paper we show how data from the standard experimental set up can be used to generate zone-axis-patterns oriented down the crystal rotation-axis. This may be used to give students direct experience with crystal shape-transforms (which help to explain anomalous peaks), as well as to the complementary relation between non-Cartesian basis-vectors in direct and reciprocal (co-vector) space.

Fraundorf, P; Garver, W; Freeman, M; Proctor, D
2013-01-01

165

www.mdpi.com/journal/ijerph Antimony Toxicity

  CiteSeer

Summary: Abstract: Antimony toxicity occurs either due to occupational exposure or during therapy. Occupational exposure may cause respiratory irritation, pneumoconiosis, antimony spots on the skin and gastrointestinal symptoms. In addition antimony trioxide is possibly carcinogenic to humans. Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. As a therapeutic, antimony has been mostly used for the treatment of leishmaniasis and schistosomiasis. The major toxic sideeffects of antimonials as a result of therapy are cardiotoxicity (~9 % of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections. Quality control of each batch of drugs produced and regular monitoring for toxicity is required when antimonials are used therapeutically.

International Journal Of; Shyam Sundar; Jaya Chakravarty

166

Monoamines and Nitric Oxide Are Employed by Afferents Engaged in Midline Thalamic Regulation

  CiteSeer

Summary: The neurochemical identities of afferents to the midline thalamus were investigated in chloral hydrate-anesthe-tized adult Sprague-Dawley rats. The retrograde tracers, FluoroGold or cholera toxin B subunit, were centered on the paraventricular thalamic nucleus (n.Pvt), a periventri-cular member of the diffuse thalamocortical projection sys-tem that is reciprocally linked with visceral areas of cere-bral cortex and implicated in food intake and addictive behavior. Tissues were processed with antisera raised against 5HT, the catecholamine-synthesizing enzymes, ty-rosine hydroxylase or phenylethanolamine Nmethyltrans-ferase or the cholinergic anabolic enzyme, ChAT. Seroto-nergic afferents principally derive from dorsal and median constituents of the mesopontine raphe. Previously unrec-ognized sources of catecholaminergic afferents were de-

Kazuyoshi Otake Is; David A. Ruggierois

167

Substance name Butyl benzyl phthalate (BBP)

  CiteSeer

Summary: Butylbenzyl phthalate has been classified as a developmental and a reproductive toxicant by the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction 1 and by the state of California. 2 The National Toxicology Program concluded that there is clear evidence of developmental toxicity and some evidence of male reproductive toxicity. 1 Efffects in animals included reduced sperm counts, reduced male fertility, prenatal mortality, and skeletal, visceral, and external malformations. 1 Butylbenzyl phthalate has been classified as a Category 1 endocrine disruptor by the European Union. 3 Exposure The Danish EPA found butylbenzyl phthalate in the coating of a wood toy. 4 A Dutch study of plastics in children’s products found butylbenzyl phthalate in 2 out of 7 polyurethane plastics. 5 Mono-benzyl

unknown authors

168

Vitreous Humour Extrusion after Suxamethonium Induction of Anaesthesia in a Polytraumatized Patient: A Case Report

  CiteSeer

Summary: Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Suxamethonium, a deepolarizing muscle relaxant, increases intraocular pressure. It is therefore advised to be avoided in open globe surgery, for fear of extruding ocular contents. Several anecdotal reports support this fear. Some workers however, dispute this claim. There is as yet no formal case report in the literature on the subject. Case Presentation. A 34-year old Nigerian male, was involved in a road traffic accident. He presented at the Accident & Emergency Unit of our hospital about 2 hours after the accident. Clinical examination revealed right corneal laceration (with intact ocular contents) and intra-abdominal visceral injury.

Article Id; Frederick Ebegue Amadasun; Theodore Ojeide Isesele

169

Generalized AA amyloidosis and fibrino-hemorrhagic pancreatitis in a Gazelle subgutturosa: a case report

  CiteSeer

Summary: ABSTRACT: Generalized AA Amyloidosis and fibrino-hemorrhagic pancreatitis were diagnosed in a 6-year-old, male Gazelle subgutturosa submitted for necropsy from a Wild Animal Production Station in Malatya, a province from eastern Turkey. Adhesions between the visceral surfaces of abdominal organs including the liver, pancreas, diaphragma and spleen were observed in the necropsy. Microscopically, the mass consisted of fibrino-hemorrhagic pancreatic tissue. Chronic inflammatory reactions characterized by mononuclear cell infiltration and fibrous connective tissue proliferation were found on the serosal surface in the liver. Amyloid depositions were detected and confirmed by Congo red stained sections of the pancreas, liver, kidneys, and spleen viewed under a polarized light microscope. Generalized AA amyloidosis was thought to responsible for a chronic inflammation characterized by adhesions in Gazelle subgutturosa. Generalized AA amyloidosis along with pancreatic involvement and fibrinohemorrhagic changes are described for the first time in the Gazelle subgutturosa species.

A. O. Ceribasi; Y. Eroksuz; S. Ceribasi; H. Ozer

170

Review Complexities of Assessing the Disease Burden Attributable to Leishmaniasis

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Summary: Abstract: Among parasitic diseases, morbidity and mortality caused by leishmaniasis are surpassed only by malaria and lymphatic filariasis. However, estimation of the leishmaniasis disease burden is challenging, due to clinical and epidemiological diversity, marked geographic clustering, and lack of reliable data on incidence, duration, and impact of the various disease syndromes. Non-health effects such as impoverishment, disfigurement, and stigma add to the burden, and introduce further complexities. Leishmaniasis occurs globally, but has disproportionate impact in the Horn of Africa, South Asia and Brazil (for visceral leishmaniasis), and Latin America, Central Asia, and southwestern Asia (for cutaneous leishmaniasis). Disease characteristics and challenges for control are reviewed for each of these foci. We recommend review of reliable secondary data sources and collection of baseline active survey data to improve current disease burden estimates, plus the improvement or establishment of effective surveillance systems to monitor the impact of control efforts.

Caryn Bern; James H. Maguire; Jorge Alvar

171

REVIEW Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

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Summary: # The Author(s) 2010. This article is published with open access at Springerlink.com Abstract Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially visceral], glucose intolerance, endothelial dysfunction), each of which is an independent risk factor for cardiovascular disease (CVD). Multiple prospective studies have documented an association between insulin resistance and accelerated CVD in patients with type 2 diabetes, as well as in non-diabetic individuals. The molecular causes of insulin resistance, i.e. impaired insulin signalling through the phosphoinositol-3 kinase pathway with intact signalling through the mitogen-activated protein kinase pathway, are responsible for the impairment in insulin-stimulated glucose metabolism and contribute to the accelerated rate of CVD in

R. A. Defronzo; R. A. Defronzo
2009-01-01

172

Quantitative studies of pinocytosis. I. Kinetics of uptake of t2~l-polyvinylpyrrulidine by rat yolk sac cultured in vitro

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Summary: A method is described for the in vitro culture of 17.5-day rat visceral yolk sac. Tissue survival was good as judged by light and electron microscopy. The rate of pinocytic uptake of ~25I-labeled polyvinylpyrrolidone by the tissue was constant both within and between experiments. Within the concentration range 0.15-24 ~tg/ml, the a2~I-labeled polyvinylpyrrolidone neither stimulated nor inhibited pinocytosis. The system offers many advantages in the quantitative study of the physical basis of pinocytosis. Many important questions concerning pinocytosis remain unanswered. For example, do pinocyticaily ingested solutes enter chiefly in free solution, or adsorbed to the plasma membrane? By what means and to what extent can pinocytosis be stimulated and inhibited? Such questions can be answered only by experiments in which pinocytosis

Kenneth E. Williams; Elizabeth M. Kidston; Felix Beck; John B. Lloyd
1975-01-01

173

Ozernaya River System, Kamchatka

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Summary: Abstract.-Adult sockeye salmon Oncorhynchus nerka from the Ozernaya River near the outlet of Lake Kuril were infected with Myxobolus arcticus (Myxozoa) in the brain and spinal cord and with Philonema oncorhynchi (Nematoda) in the peritoneal cavity. Some of these sockeye salmon were affected by light visceral adhesions. This pathological condition was found in male fish only. Myxobolus arcticus was also found in the brain of adult Dolly Varden Salvelinus malma from a river flowing into Lake Kuril. There was no substantial difference in spore measurement of M. arcticus from salmonids among Kamchatka (Russia), Hokkaido (Japan), and British Columbia (Canada). The Dolly Varden carried Salmincola carpionis (Copepoda) on the roof and floor of the buccal cavity and Anisakis

Hokkaido Salmon Iiatcbery; Kazuya Nagasawa; Shigehiko Urawa; Vladimir A. D~binin

174

Using DECA to Design Automobiles with Affective Features

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Summary: Abstract—Traditionally, product designers believe that the most effective strategy to enhance customer satisfaction is to improve the design performance. However, currently functionality is more and more taken for granted. Customers are looking for a new fulfillment at a different perspective of appreciation. Products are expected to generate pleasurable sensations and experiences. Affect and emotions play an important role in customers ’ evaluation, and it is essential, to investigate how affective products can be designed. In this study, the objective was to help designer understand and include affect and emotions into the automobile design process. Affective design can be decomposed into three distinct levels: visceral, behavioral and reflective. Design Equation for Citarasa Analysis method (DECA), which involves affective requirements, was developed to aid the design process. Index Terms—affective design, automobile, Citarasa, DECA. I.

Hong Peng; Martin G. Hel

175

Premature Decline of Serum Total Testosterone in HIV- Infected Men in the HAART-Era

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Summary: Background: Testosterone (T) deficiency remains a poorly understood issue in men with Human Immunodeficiency Virus (HIV). We investigated the gonadal status in HIV-infected men in order to characterize T deficiency and to identify predictive factors for low serum T. Methodology/Principal Findings: We performed a cross-sectional, observational study on 1325 consecutive HIV male outpatients, most of them having lipodystrophy. Serum total T,300 ng/dL was used as the threshold for biochemical T deficiency. Morning serum total T, luteinizing hormone (LH), estradiol, HIV parameters, and body composition parameters by CT-scan and Dual-Energy-X-ray-Absorptiometry were measured in each case. Sexual behavior was evaluated in a subset of 247 patients. T deficiency was found in 212 subjects, especially in the age range 40–59, but was frequent even in younger patients. T deficiency occurred mainly in association with low/normal serum LH. Adiposity was higher in subjects with T deficiency (p,0.0001) and both visceral adipose tissue and body mass index were the main negative predictors of serum total T. Osteoporosis and erectile dysfunction were present in a similar percentage in men with or without T deficiency. Conclusions/Significance: Premature decline of serum T is common (16%) among young/middle-aged HIV-infected men and is associated with inappropriately low/normal LH and increased visceral fat. T deficiency occurs at a young age and may be considered an element of the process of premature or accelerated aging known to be associated with HIV infection. The

Vincenzo Rochira; Lucia Zirilli; Gabriella Orl; Daniele Santi; Giulia Brigante; Chiara Diazzi; Federica Carli; Cesare Carani; Giovanni Guaraldi

176

96 Current Molecular Medicine 2012, 12, 96-110 Basal Breast Cancer: A Complex and Deadly Molecular Subtype

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Summary: Abstract: During the last decade, gene expression profiling of breast cancer has revealed the existence of five molecular subtypes and allowed the establishment of a new classification. The basal subtype, which represents 15-25 % of cases, is characterized by an expression profile similar to that of myoepithelial normal mammary cells. Basal tumors are frequently assimilated to triple-negative (TN) breast cancers. They display epidemiological and clinico-pathological features distinct from other subtypes. Their pattern of relapse is characterized by frequent and early relapses and visceral locations. Despite a relative sensitivity to chemotherapy, the prognosis is poor. Recent characterization of their molecular features, such as the dysfunction of the BRCA1 pathway or the frequent expression of EGFR, provides opportunities for optimizing the systemic treatment. Several clinical trials dedicated to basal or TN tumors are testing cytotoxic agents and/or molecularly targeted therapies. This review summarizes the current state of knowledge of this aggressive and hard-to-treat subtype of breast cancer.

F. Bertucci; P. Finetti; D. Birnbaum; Marseille Umr Inserm Marseille

177

Downloaded from

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Summary: ABSTRACT. This article translates aspects of Freud’s analysis of uncanny experiences and feelings using Silvan Tomkins ’ writing on the taboos on looking and phantom limb phenomenon. Centering on a poem by Emily Dickinson that has often been read in terms of the return of the repressed, the article argues that Dickinson’s poem may be better understood using the idea of the sudden return or quickening of old, forgotten and overwritten visceral or kinesthetic theories. The article suggests that both Dickinson’s poem and Freud’s essay register peculiar experiences conditioned by photography as the graphic reproduction of facial affect, and proposes Tomkins’ affect theory as a tool for better describing these media conditions. KEY WORDS: affect, memory, perception, phantom limb phenomenon, photography, poetry, uncanny There is a footnote in the last section of the essay ‘The “Uncanny” ’ that makes me laugh. Freud (1919/1953) has just begun in the body of the essay to distinguish ‘the uncanny that we actually experience [from] the uncanny

Adam Frank; Silvan Tomkins; Affective Prosthetics; Adam Frank

178

Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality

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Summary: The phlebotomine sand fly Lutzomyia longipalpis is the most important vector of American visceral leishmaniasis (AVL), the disseminated and most serious form of the disease in Central and South America. In the natural environment, most female L. longipalpis are thought to survive for less than 10 days and will feed on blood only once or twice during their lifetime. Successful transmission of parasites occurs when a Leishmania-infected female sand fly feeds on a new host. Knowledge of factors affecting sand fly longevity that lead to a reduction in lifespan could result in a decrease in parasite transmission. Catalase has been found to play a major role in survival and fecundity in many insect species. It is a strong antioxidant enzyme that breaks down toxic reactive oxygen species (ROS). Ovarian catalase was found to accumulate in the developing sand fly oocyte from 12 to 48 hours after blood feeding. Catalase expression in ovaries as well as oocyte numbers was found to decrease with age. This reduction was not found in flies when fed on the antioxidant ascorbic acid in the sugar meal, a condition that increased mortality and activation of the prophenoloxidase cascade. RNA interference was used to silence catalase gene expression in female Lu. longipalpis. Depletion of catalase led to a significant increase of mortality and a reduction in the number of developing oocytes produced after blood feeding. These results demonstrate the central role

Hector Diaz-albiter; Roanna Mitford; O A. Genta; Mauricio R. V. Sant’anna; Rod J. Dillon
2010-01-01

179

Spontaneous pneumothorax as a first sign of pulmonary carcinoma

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Summary: which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background: Spontaneous pneumothorax (SP) is a rare manifestation of lung cancer. The mechanisms by which pneumothorax occurs in lung cancer is not clear, resulting in different views being expressed. Case presentation: Here we present a case in which pneumothorax occurred as a first manifestation of lung cancer. The chest x-ray of a 68 year old man revealed a right partial pneumothorax. VATS was then performed: the visceral pleura lying over segment S3 was destroyed and air leaks were found in this section. Pathologic examination of the biopsy specimen revealed non-small cell carcinoma. Thoracoscopic talc pleurodesis was performed. Conclusion: Spontaneous pneumothorax in association with lung cancer is rarely seen. Pneumothorax can be the first sign of lung cancer. The most common possibility for SP complicating lung cancer is the tumor necrosis mechanism or, in separate cases, rupture of the emphysematous bullae. Lung cancer should always be considered as a possible cause of SP in elderly patients or in heavy smokers.

Vladislavas Vencevi?ius; Saulius Cic?nas; Open Access

180

Review Article The Role of Salt in the Pathogenesis of

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Summary: License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Metabolic syndrome, as manifested by visceral obesity, hypertension, insulin resistance, and dyslipidemia, is reaching epidemic proportions in the Western World, specifically the United States. Epidemiologic studies suggest that the increased prevalence of metabolic syndrome directly correlates with an increase in the consumption of fructose, mainly in the form of high-fructose corn syrup. This inexpensive alternative to traditional sugar has been increasingly utilized by the food industry as a sweetener since the 1960s. While augmented caloric intake and sedentary lifestyles play important roles in the increasing prevalence of obesity, the pathogenesis of hypertension in metabolic syndrome remains controversial. One intriguing observation points to the role of salt in fructose-induced hypertension. Recent studies in rodents demonstrate that increased dietary fructose intake stimulates salt absorption in the small intestine and kidney tubules, resulting in a state of salt overload, thus setting in motion a cascade of events that will lead to hypertension. These studies point to a novel interaction between the fructose-absorbing transporter, Glut5, and the salt transporters, NHE3 and PAT1, in the intestine and kidney proximal tubule. This paper will focus on synergistic roles of

Fructose-induced Hypertension; Manoocher Soleimani; Pooneh Alborzi

181

Risk of Infection with Leishmania spp. in the Canine Population in the Netherlands

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Summary: 195-201. – The dog is the main reservoir of Leishmania infantum, the causative agent of visceral leishmaniasis (VL) in humans in Southern Europe. In order to identify the risk of dogs from a Leishmania non-endemic area traveling to a Leishmania-endemic area becoming infected and the risk of transmitting infection to humans in non-endemic areas an investigation was performed, in which the results of a questionnaire were combined with the results of a serologic survey. The questionnaire was sent to 1478 at random chosen families in the Netherlands. Of the 59.0 % responders 28.0 % had one or more dogs and 4.8 % of these dogs had visited Southern Europe during the summer period of that year. On a total population of 1,200,000 dogs in the Netherlands, this means that each year some 58,000 dogs are at risk of being exposed to a Leishmania infection in Southern Europe. During the period 1990-1992 blood was collected for serology in 1911 dogs presented to the Utrecht University Clinic because of clinical problems not related to leishmaniasis, of which 434 had been in Southern Europe in the foregoing years. None was serologically positive. From these data it can be deduced that the highest chance to obtain

E. Teske; F. Van Knapen; E. G. M. Beijer

182

Quantitative studies of pinocytosis. II. Kinetics of prolein uptake and digestion by rat yolk sac cultured in vitro

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Summary: Pinocytic uptake of l~5l-labeled bovine serum albumin by 17.5-day rat visceral yolk sac cultured in vitro has been examined. Uptake was followed by intracellular digestion and, after an initial period, the content of radioactivity in the tissue itself remained constant during the incubation. Radiolabel was returned to the culture medium predominantly as [125I]iodotyrosine; exocytosis of undigested protein did not occur. The rate of uptake of labeled protein, which was constant within an experiment and reproducible between experiments, was much higher than that of a nondigestible macromolecule, l~l-labeled polyvinylpyrrolidone. The higher rate of uptake was a consequence of the protein entering the cells chiefly by adsorption to the plasma membrane being internalized; ~25I-labeled albumin did not stimulate, nor did 125I-labeled polyvinyipyrrolidone inhibit pinocytosis. Different preparations of ~5I-labeled albumin had characteristically different rates of uptake, probably reflecting differences in affinity for plasma membrane receptors. The physiological

Kenneth E. Williams; Elizabeth M. Kidston; Felix Beck; John B. Lloyd
1975-01-01

183

Adipose tissue, inflammation, and cardiovascular disease. Circ Res

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Summary: Abstract—Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. Circulating mediators of inflammation participate in the mechanisms of vascular insult and atheromatous change, and many of these inflammatory proteins are secreted directly from adipocytes and adipose tissue–derived macrophages. Several factors linking obesity with an increased cardiovascular risk have been identified. The adipocyte-specific secretory protein adiponectin is a particularly promising candidate in this context. Its levels are decreased in obesity. Adiponectin may mediate some of its demonstrated cardioprotective effects through its anti-inflammatory properties. In addition to decreased expression of beneficial adipokines, secretion of a host of inflammatory factors from visceral adipose tissue may contribute to the increased cardiovascular risk associated with obesity. The cardioprotective effects of many of the most popular drug regimens corroborate these conclusions, demonstrating that along with improvements in other therapeutic end points, they mediate improvements in systemic inflammation. In some cases, these improvements are attributable to direct suppression of inflammatory signaling in adipocytes. The targeted suppression of various proinflammatory cascades in

Anders H. Berg; Circ Res; Anders H. Berg

184

Open Access Solitary fibrous tumor of the liver: a case report

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Summary: Hepatic solitary fibrous tumor (SFT) is a rare tumor originating from the mesenchyme. Here we report a new case of SFT in the liver and review the clinical presentation, radiological and operative findings, diagnosis, treatment, and outcome. The patient was a 59-year-old man who presented with progressive fatigue for 3 months and an abdominal mass for 3 days. On laboratory tests, no abnormality was detected except that abdominal ultrasonography revealed a 9.0 × 6.2 cm hypoechogenic mass in the left lobe of the liver. A computed tomographic scan confirmed a hypodense lesion in the left lobe of the liver. The patient underwent left hepatectomy. SFT was diagnosed on the basis of histopathological findings. The patient was free from all symptoms and had no signs of local recurrence after 24 months ’ follow up. Background Solitary fibrous tumor (SFT) is a rare spindle-cell neoplasm of mesenchymal origin, first described by Klemperer and Robin in the visceral pleura in 1931 [1]. It usuallyisfoundinthethoraciccavityandpleura,but, rarely, it can involve other organs such as the mediastinum

Case Report; Ke Sun; Jian-ju Lu; Xiao-dong Teng; Li-xiong Ying; Jian-feng Wei

185

REVIEW Detection of metabolic syndrome features among childhood cancer survivors: A target to prevent disease

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Summary: Abstract: Along with the growing epidemic of obesity, the risk of atherosclerosis, cardiovascular disease morbidity, and mortality are increasing markedly. Several risk factors for cardiovascular disease, such as visceral obesity, glucose intolerance, arterial hypertension, and dyslipidemia commonly cluster together as a condition currently known as metabolic syndrome. Thus far, insulin resistance, and endothelial dysfunction are the primary events of the metabolic syndrome. Several groups have recommended clinical criteria for the diagnosis of metabolic syndrome in adults. Nonetheless, in what concerns children and adolescents, there are no unified definitions, and modified adult criteria have been suggested by many authors, despite major problems. Some pediatric disease states are at risk for premature cardiovascular disease, with clinical coronary events occurring very early in adult life. Survivors of specific pediatric cancer groups, particularly acute lymphocytic leukemia, central nervous system tumors, sarcomas, lymphomas, testicular cancer, and following bone marrow transplantation, may develop metabolic syndrome traits due to: hormonal deficiencies (growth hormone deficiency, thyroid dysfunction, and gonadal failure), drug or radiotherapy damage, endothelial impairment, physical inactivity, adipose tissue dysfunction, and/or drug-induced magnesium deficiency. In conclusion, some primary and secondary prevention remarks are proposed in order to reduce premature cardiovascular disease risk in this particular group of patients.

Adriana Aparecida Siviero; Angela Maria Spinola; Gil Guerra-junior

186

Hysterectomy and Bilateral Salpingoovariectomy in a Transsexual Subject without Visible Scaring

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Summary: Copyright © 2010 Anna Myriam Perrone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective. To report on the use of laparoendoscopic single-site surgery (LESS) for the management of total hysterectomy (TH) with bilateral salpingoovariectomy (BSO) in a subject affected by gender identity disorder. Design.Casereport.Setting. University Hospital. Patient(s). A 27-year-old affected by Gender Identity Disorder underwent a hysterectomy and BSO as part of surgical sex reassignment. Intervention(s). Laparoendoscopic single-site surgery access for TH and BSO. Main Outcome Measure(s). The procedure was performed without incident. The trocar placement was easy and safe, without inadvertent port removal. No vascular or visceral injuries, loss of pneumoperitoneum, or intraoperative port site bleeding occurred. Result(s). A detailed description of the technique of a single-site surgery for management of hysterectomy and BSO. Conclusion. Our case presents the first report of single-site surgery for surgical treatment of subjects affected by GID. 1.

Article Id; Anna Myriam Perrone; Maria Cristina Scifo; Valentina Martelli; Paolo Casadio; Paolo Giovanni Morselli; Maria Cristina Meriggiola
2010-01-01

187

Impact of Resistant Starch on Body Fat Patterning and Central Appetite Regulation

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Summary: Background. Adipose tissue patterning has a major influence on the risk of developing chronic disease. Environmental influences on both body fat patterning and appetite regulation are not fully understood. This study was performed to investigate the impact of resistant starch (RS) on adipose tissue deposition and central regulation of appetite in mice. Methodology and Principle Findings. Forty mice were randomised to a diet supplemented with either the high resistant starch (HRS), or the readily digestible starch (LRS). Using 1 H magnetic resonance (MR) methods, whole body adiposity, intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL) were measured. Manganese-enhanced MRI (MEMRI) was used to investigate neuronal activity in hypothalamic regions involved in appetite control when fed ad libitum. At the end of the interventional period, adipocytes were isolated from epididymal adipose tissue and fasting plasma collected for hormonal and adipokine measurement. Mice on the HRS and LRS diet had similar body weights although total body adiposity, subcutaneous and visceral fat, IHCL, plasma leptin, plasma adiponectin plasma insulin/glucose ratios was significantly greater in the latter group. Adipocytes isolated from the LRS group were significantly larger and had lower insulin-stimulated glucose

Po-wah So; Wei-sheng Yu; Yu-ting Kuo; Clive Wasserfall; Anthony P. Goldstone; Jimmy D. Bell; Gary Frost

188

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

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Summary: Leishmania major promastigotes were found to avoid activation of mouse bone marrow-derived macrophages (BMMo) in vitro for production of cytokines that are typically induced during infection with other intracellular pathogens. Coexposure of BMMo to the parasite and other microbial stimuli resulted in complete inhibition ofinterleukin (IL) 12 (p40) mRNA induction and IL-12 release. In contrast, mRNA and protein levels for IL-lot, IL-113, tumor necrosis factor (TNF) ci, and inducible NO synthase (iNOS) were only partially reduced, and signals for IL-10 and monocyte chemoattractant protein (MCP-1/JE) were enhanced. The parasite could provide a detectable trigger for TNF-cx and iNOS in BMMo primed with interferon (IFN) y, but still failed to induce IL-12. Thus IL-12 induction is selectively impaired after infection, whereas activation pathways for other monokine responses remain relatively intact. Selective and complete inhibition of IL-12(p40) induction was observed using BMMo from either genetically susceptible or resistant mouse strains, as well as IL-10 knockout mice, and was obtained using promastigotes from cutaneous, visceral, and lipophosphoglycan-deficient strains of Leishmania. The impaired production of the major physiologic inducer oflFN-y is suggested to underlie the relatively prolonged interval of parasite intracellular survival and replication that is

Lucia Carrera; Ricardo T. Gazzinelli; R. Affaello Badolato; Sara Hieny; Werner Mfillerfl Ralfk/ihnfl; David L. Sacks
1996-01-01

189

Salmon Aquaculture and Transmission of the Fish Tapeworm

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Summary: Aquaculture of salmon constitutes a rapidly growing worldwide industry with an expanding globalized market (1,2). Although this industry has several economic benefits, according to recent reports it is also accompanied by effects that are detrimental to human and animal health and the environment (1,2). Aquaculture has been implicated in the transmission of infectious diseases. For example, in caged fish aquaculture, bacterial and parasitic diseases can be transmitted to wild fish (1,2). Furthermore, aquaculture-raised fish may be susceptible to the microorganisms and parasites of wild fish (1,3). However, in spite of the accepted fact that parasitic worms can be transmitted to humans by free-ranging fish (4), until recently, few examples have been reported of pathogens that could be transmitted to humans directly by the products and subproducts of salmon aquaculture. I discuss here information indicating that salmon aquaculture may be involved in expanding the range of fish tapeworm infections in nature and to humans. Several recent publications report outbreaks of human cases of infection by the fish tapeworm Diphyllobothrium latum in Brazil (5–9). These infections have been epidemiologically linked to consumption of raw salmon produced by the aquaculture industry in southern Chile, thousands of miles away (5–9). Infections by D. latum have been detected in several cities in Brazil (5–9), and in a tourist who traveled there from Europe (10). These cases of diphyllobothriasis are noteworthy because this parasite was totally unknown to clinicians and parasitologists in Brazil, where it does not appear to have an endemic life cycle (5–9). D. latum is transmitted to humans by plerocercoid larvae present in fish meat and visceral organs (www.dpd.cdc.gov/dpdx). D. latum and the closely related sea gull tapeworm, D. dendriticum, have well-established endemic life cycles in a series of glacial lakes that dot Region XIX and Region X in northern Chilean Patagonia.

Felipe C. Cabello

190

REVIEW Milk protein for improved metabolic health: a review of the evidence

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Summary: Epidemiological evidence shows that consumption of dairy products is associated with decreased prevalence of metabolic related disorders, whilst evidence from experimental studies points towards dairy protein as a dietary component which may aid prevention of type 2 diabetes (T2DM). Poor metabolic health is a common characteristic of overweight, obesity and aging, and is the forerunner of T2DM and cardiovascular disease (CVD), and an ever increasing global health issue. Progressive loss of metabolic control is evident from a blunting of carbohydrate, fat and protein metabolism, which is commonly manifested through decreased insulin sensitivity, inadequate glucose and lipid control, accompanied by a pro-inflammatory environment and hypertension. Adverse physiological changes such as excess visceral adipose tissue deposition and expansion, lipid overspill and infiltration into liver, muscle and other organs, and sarcopaenia or degenerative loss of skeletal muscle mass and function all underpin this adverse profile. ‘Sarcobesity ’ and sarcopaenic diabetes are rapidly growing health issues. As well as through direct mechanisms, dairy protein may indirectly improve metabolic health by aiding loss of body weight and fat mass through enhanced satiety, whilst promoting skeletal muscle growth and function through anabolic effects of dairy protein-derived branch chain amino acids (BCAAs). BCAAs enhance muscle protein synthesis, lean body mass and skeletal muscle metabolic function. The composition and processing of dairy protein has an impact on digestion, absorption, BCAA kinetics and function, hence the optimisation of dairy protein composition through selection and combination of specific protein components in milk may provide a way to maximize benefits for metabolic health.

Robin A Mcgregor

191

DISPATCHES

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Summary: Sequence analysis of the full-length medium segment and the partial small and large segments of a hantavirus, detected by reverse transcription–PCR in lung tissues of the Chinese mole shrew (Anourosorex squamipes) captured in Cao Bang Province, Vietnam, in December 2006, indicated that it is genetically distinct from rodentborne hantaviruses. Insectivores (or soricomorphs) have been largely ignored as being important in the evolutionary dynamics of hantaviruses, despite the isolation of Thottapalayam virus (TPMV) from the Asian house shrew (Suncus murinus) (1,2) and the detection of hantavirus antigens in tissues of the Eurasian common shrew (Sorex araneus), alpine shrew (S. alpinus), Eurasian water shrew (Neomys fodiens), and common mole (Talpa europea) (3). Recently, genetically distinct hantavirus sequences have been found by reverse transcription–PCR in the Therese shrew (Crocidura theresae) in Guinea (4) and the northern short-tailed shrew (Blarina brevicauda) in the United States (5). In addition, a phylogenetically distinct hantavirus has been isolated from lung tissues of the Ussuri shrew (C. lasiura), captured along the Imjin River near the demilitarized zone in South Korea (J.-W. Song and R. Yanagihara, unpub. data). The Study To further investigate the existence and phylogeny of nonrodentborne hantaviruses, we analyzed lung and other visceral tissues, collected in RNAlater Stabilization Reagent (QIAGEN, Valencia, CA, USA), from 24 soricomorphs, including 9 white-toothed shrews (Crocidura spp.), 3 Chinese mole shrews (Anourosorex squamipes), and 12 longnosed moles (Euroscaptor longirostris), captured in northern, central, and southern Vietnam during November and December 2006. RNA, extracted from 20–50 mg of each tissue by using the RNA-Bee isolation kit (TEL-TEST,

Thang T. Truong; Shannon N. Bennett; Richard Yanagihara

192

The Nature of the Dietary Protein Impacts the Tissue-to- Diet 15 N Discrimination Factors in Laboratory Rats

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Summary: Due to the existence of isotope effects on some metabolic pathways of amino acid and protein metabolism, animal tissues are 15 N-enriched relative to their dietary nitrogen sources and this 15 N enrichment varies among different tissues and metabolic pools. The magnitude of the tissue-to-diet discrimination (D 15 N) has also been shown to depend on dietary factors. Since dietary protein sources affect amino acid and protein metabolism, we hypothesized that they would impact this discrimination factor, with selective effects at the tissue level. To test this hypothesis, we investigated in rats the influence of a milk or soy protein-based diet on D 15 N in various nitrogen fractions (urea, protein and non-protein fractions) of blood and tissues, focusing on visceral tissues. Regardless of the diet, the different protein fractions of blood and tissues were generally 15 N-enriched relative to their non-protein fraction and to the diet (D 15 N.0), with large variations in the D 15 N between tissue proteins. D 15 N values were markedly lower in tissue proteins of rats fed milk proteins compared to those fed soy proteins, in all sampled tissues except in the intestine, and the amplitude of D 15 N differences between diets differed between tissues. Both between-tissue and between-diet D 15 N differences are probably related to modulations of the relative orientation of dietary and endogenous amino acids in the different metabolic pathways. More specifically, the smaller D 15 N values observed in tissue proteins with milk than soy dietary protein may be due to a slightly more direct channeling of dietary amino acids for tissue protein renewal and to a lower recycling of amino acids through fractionating

Nathalie Poupin; Cécile Bos; François Mariotti; Jean-françois Huneau; Daniel Tomé

193

SAGE-Hindawi Access to Research Veterinary Medicine International Volume 2011, Article ID 850568, 5 pages doi:10.4061/2011/850568 Research Article Pathological Study of Blood Parasites in Rice Field Frogs,

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Summary: Copyright © 2011 Achariya Sailasuta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. One hundred and forty adult rice field frogs, Hoplobatrachus rugulosus (Wiegmann, 1834), were collected in Srakaew province, Thailand. For blood parasite examination, thin blood smears were made and routinely stained with Giemsa. The results showed that 70 % of the frogs (98/140) were infected with 5 species of blood parasites, including a Trypanosoma rotatorium-like organism, Trypanosoma chattoni, Hepatozoon sp. a, Hepatozoon sp. b, and Lankesterella minima. Pathological examination of the liver, lung, spleen, and kidney of the frogs that were apparently infected with one of these blood parasites were collected and processed by routine histology and subsequently stained with haematoxylin and eosin. Histopathological findings associated with the Trypanosoma rotatorium-like organism and Trypanosoma chattoni-infected frogs showed no pathological lesions. Hepatozoon sp. aandHepatozoon sp. b-infected frogs developed inflammatory lesions predominantly in the liver, demonstrating granuloma-like lesions with Hepatozoon sp. meronts at the centre. Tissue sections of Lankesterella minima-infected frogs also showed lesions. Liver and spleen showed inflammatory lesions with an accumulation of melanomacrophage centres (MMCs) surrounding the meronts and merozoites. It is suggested that Hepatozoon sp. a, Hepatozoon sp.b,andLankesterella minima-infections are capable of producing inflammatory lesions in the visceral organs of rice field frogs, and the severity of lesions is tentatively related to levels

Achariya Sailasuta; Jetjun Satetasit; Malinee Chutmongkonkul

194

KJ: Contrasting effects of WIN 55212-2 on motility of the rat bladder and uterus

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Summary: Both the uterus and bladder contain cannabinoid (CB) receptors whose functions are poorly understood. Here, in urethaneanesthetized female rats in metestrus, we simultaneously compared the effects of close-arterial injections of the cannabinoid receptor agonist WIN 55,212–2 (WIN2) on uterine contractions (amplitude and rate) and micturition thresholds (MT) assessed by cystometry. Five doses of WIN2 were delivered (0.01, 0.1, 0.5, 1, and 1.5 ?mol/kg) in three groups: (1) controls; (2) after bladder inflammation with intravesicular turpentine; and (3) after bilateral hypogastric neurectomy (HYPX). In some rats, drugs were delivered via the tail vein. Regarding bladder, WIN2 dose-dependently reduced MTs in all groups. Both bladder inflammation and HYPX significantly increased this effect. Regarding uterus, WIN2 dose-dependently increased uterine contraction amplitude. Bladder inflammation or HYPX significantly decreased this effect. Coinjection of the CB1 antagonist SR141716A (SR) (1.5 ?mol/kg) and WIN2 (0.5 ?mol/kg) abolished or reduced the effects of WIN2 in both organs. SR alone had significant effects only after HYPX, reducing both MT and uterine contraction amplitude. The vehicle (0.4 % DMSO) and inactive enantiomer S(?)-WIN 55,212–3 were both ineffective. Close-arterial injections of WIN2 (0.5 ?mol/kg) produced significantly larger effects in both organs than tail vein injections. These results indicate that, whereas WIN2 reduces bladder motility, it mainly increases uterine motility, likely via CB1 receptors located in the two organs. The opposing effects of bladder inflammation and HYPX on the potency of WIN in the two organs suggest a neurally mediated viscero-visceral interaction in which bladder inflammation influences uterine CB1 sensitivity, possibly by inhibiting adrenergic input to the uterus. Key words: cannabinoid; hypogastric nerve; inflammation; pelvic organs; lower urinary tract; reproductive organs Numerous anecdotal reports indicate that cannabinoids (CBs) affect uterine and bladder motility. Thus, cannabis has been used for more than a century to treat dysmenorrhea and menorrhagia

Natalia Dmitrieva; Karen J. Berkley

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