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Sample search results for: abcb1 mdr1 expression

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1 Reduced intracellular accumulation of calcein by overexpression of fluorescent protein fusions of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos.
 

Summary:  of the up-regulated activities is pharmacologically similar to mammalian P-gp activity (aka MDR1 or ABCB1... of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos. Amro Hamdoun1 1... fluorescent protein (FP) fusions of the ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
2 Clin Pharmacol Ther . Author manuscript Donor P-gp polymorphisms strongly influence renal function and graft
 

Summary:  3A and the efflux transporter P-glycoprotein (P-gp; ), bothABCB1 abundantly expressed in the kidney... pairwise linkage disequilibrium (LD) between polymorphisms. TheABCB1 extent of disequilibrium was expressed... S , Petrasek J , Hribova P , Novotna E , Brabcova I , ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
3 Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients with long term follow-up.
 

Summary:  transporter P- glycoprotein (P-gp; ABCB1), both abundantly expressed in the kidney. We retrospectively... disequilibrium (LD) between ABCB1 polymorphisms. The extent of disequilibrium was expressed in terms of D' and r... ., Brabcova, I. & Viklicky, O. Haplotypic ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
4 Precision-cut slices as a tool to study induction of drug metabolism
 

Summary:  M) for 24 h after which mRNA expression of both CYP3A4 and MDR1/ABCB1 (small intestine and colon (A... (30 M) for 24 h after which mRNA expression of CYP3A4, CYP2B6, UGT1A6 and ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
5 PharmGKB Submission Update: IV. PMT Submissions of Genetic Variations in ATP-
 

Summary:  and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Phar- macogenetics 13... or blood for elimination or distribution. Summary of Data Submitted: Size of sample set assayed: ABCB1... :481­494. Pauli-Magnus C, Chinn L, Brett C, ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
6 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  italic for the mouse gene, and plain font for the expressed protein: 1) ABCB1, abcb1a/b, P-gp; 2) ABCC1... ) line. The three pairs were the human adenocarcinoma cell line KB-3-1 and its ABCB1- expressing variant... higher ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
7 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  italic for the mouse gene, and plain font for the expressed protein: 1) ABCB1, abcb1a/b, P-gp; 2) ABCC1... ) line. The three pairs were the human adenocarcinoma cell line KB-3-1 and its ABCB1- expressing variant... higher ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
8 Function of prokaryotic and eukaryotic ABC proteins in lipid transport Antje Pohla,b
 

Summary:  and Gottesmann [1] pointed out that ABCB1 (MDR1 Pgp) behaved like a bflippaseQ which would be able to transport... homeostasis? ABCA10 macrophage lipid homeostasis? ABCB ABCB1 MDR1 Pgp detoxification C6-nbd-PC C6-nbd-PE C6... ...

  

Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques

 

Collection: Chemistry ; Biology and Medicine

 
9 J Biopharm Stat. Author manuscript Comparison of model-based tests and selection strategies to detect
 

Summary:  the subject of much attention, for example the ABCB1 gene coding for the PLicinio and Wong, 2002 glycoprotein... , Yamaguchi and colleagues demonstrated the impact of ABCB1 polymorphism on paclitaxel pharmacokinetics in1999... patients with ovarian cancer ( ). The ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
10 Model-based tests for pharmacogenetic analyses Comparison of model-based tests and selection strategies to detect genetic
 

Summary:  (Licinio and Wong, 2002). Some genes have already been the subject of much attention, for example the ABCB1... recently, Yamaguchi and colleagues demonstrated the impact of ABCB1 polymorphism on paclitaxel... pharmacokinetics in patients with ovarian cancer (Yamaguchi et al., 2006). The ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
11 Molecular and Cellular Endocrinology 231 (2005) 7585 Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and
 

Summary:  in this study, we first characterized the expression of SXR and its target genes CYP3A4, and MDR1 in human adult... activation of SXR. SXR has been demonstrated to be closely associated with the expression of CYP3A4 and MDR1... the expressions of ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
12 Breed distribution and history of canine mdr1-1 , a pharmacogenetic mutation that marks the
 

Summary:  mice lacking Abcb1a, the murine ortholog of MDR1 (13). Mealey et al. (14) investigated canine MDR1... Breed distribution and history of canine mdr1-1 , a pharmacogenetic mutation that marks... in the canine multidrug ...

  

Source: Broman, Karl W. - Department of Biostatistics and Medical Informatics, University of Wisconsin at Madison; Slatkin, Montgomery - Department of Integrative Biology, University of California at Berkeley

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
13 Published on Web Date: October 21, 2010 r 2010 American Chemical Society 82 DOI: 10.1021/cn100078a |ACS Chem. Neurosci. (2011), 2, 8289
 

Summary:  but did not inhibit MRP1. Accumulation of the fluorescent substrate calcein-AM in ABCB1-expressing cells... trans- porter (Table 1). At 100 nM, tariquidar decreased the resistance of ABCB1-expressing cells... confirmed that tariquidar is not a substrate for P-gp ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
14 Ecole Polytechnique Thse de doctorat
 

Summary:  .3 ABCA12 2q34 ABCA/ABC1 ABCA13 7p12.3 ABCB1 MDR1, P-gp, ABC20, GP170, PGY1 7q21.1 ABCB2 TAP1, PSF1, RING4... 2 NH2 COOH a) ABCC7/CFTR ABCB1/P-gP ABCC1/MRP1 ABCB2-3/TAP R b) R TMD NBD Domaine régulateur pastel... ), troubles respiratoires, infectieux ou alimentaires ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
15 Coordinated regulation of drug metabolizing enzymes, transporters and nuclear receptors
 

Summary:  -on-DemandTM Gene Expression Products were purchased for villin, GAPDH, UGT1A1, UGT1A6, SULT2A1, GSTA1 and MDR1/ABCB... UGT1A6 (4-fold), also mRNA expression of the transporters MDR1/ABCB1 (2.5-fold), ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
16 European Journal of Clinical Pharmacology manuscript No. (will be inserted by the editor)
 

Summary:  the impact on indinavir pharmacokinetics of ABCB1 polymorphisms, a gene inserm-00384935,version1-17May2009... shown that the ABCB1 C3435T genotype affects the absorption constant of indi- navir whereas Verstuyft et... Kit (Qiagen, Courtaboeuf, France). ABCB1 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
17 Antimicrob Agents Chemother . Author manuscript Population pharmacokinetic-pharmacogenetic study of nevirapine in
 

Summary:  of variability focusing on the , and ( genes.CYP2B6 CYP3A5 ABCB1 MDR1) 170 Cambodian HIV-infected patients were... ( ). and ( , which endcodes for P-glycoprotein) are known to be highly polymorphic (1 CYP3A5, CYP2B6 ABCB1 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
18 College/University: 1998 -2004 University of Kaiserslautern (Germany)
 

Summary:  in January 2005 Title of Thesis: ,,Analysis of conditional mdr-1 expression in human cells" Diploma work done... of chemoresistance genes (MGMT/Mdr-1) in haematopoietic cells Scientific Interests and Goals: The main interest of my... ) Tet-regulated expression of ...

  

Source: Manstein, Dietmar J. - Department of Biophysical Chemistry, Medizinische Hochschule Hannover

 

Collection: Biology and Medicine

 
19 Functional hot spots in human ATP-binding cassette transporter
 

Summary:  ABCB11 V444A NBD1 Neutral BSEP ABCB11 E1186K NBD2 Disease MDR1 ABCB1 P1051A NBD2 Neutral MDR1 ABCB1 S... 1141T NBD2 Neutral MDR1 ABCB1 T1256K ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
20 ANRS12154Pecan_NVP_v1_dernier enregistrement par Anne-Marie Population pharmacokinetic-pharmacogenetic study of1
 

Summary:  focusing on the5 CYP2B6, CYP3A5 and ABCB1 (MDR1) genes.6 170 Cambodian HIV-infected patients were included... enregistrement par Anne-Marie glycoprotein efflux transporter (1). CYP3A5, CYP2B6 and ABCB1 (MDR1, which endcodes... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics


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21 368 VOLUME 86 NUMBER 4 | OCTOBER 2009 | www.nature.com/cpt STATE ART nature publishing group
 

Summary:  , ABCB1 has been most studied because it encodes P-glycoprotein ((P-gp) or multidrug resistance 1 (MDR1... -gp (ABCB1), ABCG2, and sev- eral transporters of the ABCC family, most of which are apically (blood... -knockout mice ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
22 STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines
 

Summary:  selected for resistance to doxorubicin and is known to overexpress the MDR1 (ABCB1) efflux protein.10,20 We... -PCR (Table I). One of the highly overex- pressed genes (32-fold) was the efflux protein ABCB1 (MDR1... in this ...

  

Source: Uppsala Universitet, Department of Material Science, Signals and Systems Group

 

Collection: Engineering

 
23 Introduction to multidrug transporters, cellular resistance and lantibiotic production in Lactococcus lactis
 

Summary:  transporter ABCB1 (P-glycoprotein or MDR1) is a full- transporter in which a single polypeptide encompasses... its high sequence similarity to the human multidrug resistance protein ABCB1 (MDR1, P... ­ the human ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
24 Transmembrane Inhibitors of P-Glycoprotein, an ABC Transporter Nadya I. Tarasova,*, Rishi Seth, Sergey G. Tarasov, Teresa Kosakowska-Cholody, Christine A. Hrycyna,#,
 

Summary:  -852 was not found Figure 1. Inhibition of rhodamine 123 efflux from NIH/3T3 cells stably expressing MDR1 detected... ability to sensitize highly resistant human colon cancer cells HCT15, which express a high level of MDR1... of the ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
25 The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals
 

Summary:  ,28 =0.637, p=0.640). 3.3. Expression and localization of ABCB1 (P-gp) Immunochemical detection of P... ). ThPgpisoform 2 and CgPgpisoform1 clusters with human ABCB1, ABCB4, ABCB5 and ABCB11 genes. ABCB1 (MDR... , similar to ...

  

Source: Sotka, Erik - Grice Marine Laboratory, College of Charleston

 

Collection: Environmental Sciences and Ecology

 
26 Contribution to Substrate Specificity and Transport of Nonconserved Residues in Transmembrane Domain 12 of Human P-Glycoprotein
 

Summary:  compounds (1, 2). Expression of MDR1 in cancer cells confers resistance to multiple chemo- therapeutic... -type or mutant MDR1 cDNAs were cloned into a vaccinia expression vector (pTM1) downstream from a T7 promoter... infected with vTF 7-3 virus and transfected with ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
27 Heterologously expressed bacterial and human multidrug resistance proteins confer cadmium resistance
 

Summary:  in cadmium resistance, human MDR1, Lactococcus lactis lmrA, and Oenococcus oeni omrA were expressed... introduced by expression of the hMDR1 transporter. E. coli CS1562 (tolC- ) and JM109 (tolC+ ) were... control and ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
28 Comparison of [11 C]-(R)-PK 11195 and [11
 

Summary:  radioligands showed higher uptake in parental than ABCB1 over- expressing cells, this difference... . The three pairs were (listed as parental and resistant, respectively): KB-3-1 and KB-8-5-11 (ABCB1, also... . To determine if [3 H]PK 11195 and [3 H]PBR28 were substrates of ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
29 TOWARDS A TARGETED INHIBITION OF HEPATIC STELLATE CELL PROLIFERATION
 

Summary:  of total area. #12;Pharmacological effects of M6PHSA-DOX 133 Analysis of mdr1a and mdr1b mRNA expression... PHSA-DOX 20 mg/kg/day (n=3). mRNA expression levels of mdr1a and mdr1b The ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 Structural Flexibility of the Linker Region of Human P-Glycoprotein Permits ATP Hydrolysis and Drug Transport
 

Summary:  were excised from pSX- MDR1/A with SacII and Xhol and ligated into retroviral expression vectors, i... the wild-type gene (22). Vaccinia Virus Expression Vector Construction. To construct pTM1-MDR1... the original expression vector pTM1- ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
31 4104-8--Templeton--Ch21--R1--07-24-03 16:17:03--Selectable Markers for Gene Therapy2
 

Summary:  are transporters. expressing the MDR1 gene in their bone marrow are resistant63 to the cytotoxic effects of many... thione-S-transferases (34), and only very low levels of endog- 127 enous MDR1 gene are expressed... marrow of recipient animals. Both investigators ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
32 Molecular Biology of the Cell Vol. 7, 1485-1498, October 1996
 

Summary:  enzymes to obtain the expression vector pTM1-MDR1. To introduce the V185 mutation, we replaced the Bgl... . (A) The unique restriction sites and main features of the expression plasmid pTM1-MDR1... at the 3'-end of the MDR1 ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
33 Applied Mathematics Letters 24 (2011) 12511256 Contents lists available at ScienceDirect
 

Summary:  -modulated ABC transporter induction CPT11 exposure may enhance the expression of ABCB1 and ABCG2 both... ­10] which enhances ABCB1 expression [11,12]. In the same way, chemical stress may activate the nuclear... responsible for CPT11 efflux and stands for the ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine

 
34 ForPeerReview Expression, localization, and inducibility by bile acids of hepatobiliary transporters in
 

Summary:  ) for the efflux pumps Mdr1b/Abcb1b, Mdr2/Abcb4, Mrp1/Abcc1, Mrp2/Abcc2, Mrp3/Abcc3, Abcg5, Abcg8. This profile... expression of most ABC transporters was found. Among the nine ABC genes examined, seven (Mdr1b, Mdr2, Mrp1... transporters ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
35 Drug metabolism in human and rat intestine: An in vitro approach
 

Summary:  the tract. In contrast, Bcrp, Mdr1a, Mdr1b, Mrp3 and Ost-Ost expression increases along the length... ) Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract. Br J Clin Pharmacol 60: 54... + [113] ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
36 NEM modication prevents high-anity ATP binding to the rst nucleotide binding fold of the sulphonylurea receptor, SUR1
 

Summary:  -sensitive structure similar to that of NBF1 of MDR1, a multidrug transporter, and confirm NBF1 as the high- affinity... ) and four Kir6.2 subunits [5^8]. Like P-glycoprotein (MDR1), the multi- drug resistance-related protein (MRP... in the absence of Mg2 and that unlike ...

  

Source: Tucker, Stephen J. - Department of Physics, University of Oxford

 

Collection: Physics ; Biology and Medicine

 
37 Place du test de permutation dans les mod`eles non lineaires `a effets mixtes : application en
 

Summary:  aussi ´et´e g´enotyp´es pour 5 polymorphismes : ABCB1 exon 26 et 21, CYP3A5*3, CYP3A5*6 et CYPA4*1B... polymorphismes simul´es sur un des param`eres du mod`ele sont inspir´es des exons 26 et 21 du g`ene ABCB1, soit... A5, MDR1 and IL-10 polymorphisms in adult ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
38 P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with
 

Summary:  -glycoprotein. Neuropharmacology. 2008;55:1364­ 1375. 5. Jamroziak K, Robak T. Pharmacogenomics of MDR1/ABCB1 gene: the influence... studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... found that dLop is ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
39 UNIVERSIT PARIS.DIDEROT (Paris 7) COLE DOCTORALE : 393
 

Summary:  'excrétion d'un nombre important de médicaments (Marzolini et al., 2003). Le gène ABCB1 codant pour la P... populations caucasiennes et la fréquence du variant C3435T du gène ABCB1 est de respectivement 80% et 50% dans... simulés sont ceux des exons 26 et 21 du gène ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
40 Multidrug and peptide export in Lactococcus lactis
 

Summary:  transporter ABCB1 (P-glycoprotein or MDR1) is a full- transporter in which a single polypeptide encompasses... its high sequence similarity to the human multidrug resistance protein ABCB1 (MDR1, P... ­ the human ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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41 10.1177/0091270004269705ARTICLEKHARASCH ET ALEVALUATION OF CYP3A AND P-GLYCOPROTEIN ACTIVITIES USING ALFENTANIL AND FEXOFENADINEDRUG METABOLISM AND TRANSPORT Evaluation of First-Pass Cytochrome P4503A
 

Summary:  effect.7-10 P-glycoprotein (P-gp), the product of the MDR1 (ABCB1) gene, is an adenosine triphosphate... interactions. The human MDR1 gene is highly polymorphic, with numerous genetic variants identified and clinical... in humans to assess intestinal P-gp activity. ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
42 236 nature genetics volume 24 march 2000 A gene expression database for the
 

Summary:  gene ABCB1 (formerly MDR1) had closely related drug-activity profiles. HCT-15, with one of the highest... levels of ABCB1 expression, is a colon- derived line that clustered by gene expression pattern with other... colon ...

  

Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University; Brown, Patrick O.- Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine ; Biotechnology

 
43 Comparison of [11 C]-(R)-PK 11195 and [11
 

Summary:  radioligands showed higher uptake in parental than ABCB1 over- expressing cells, this difference... . The three pairs were (listed as parental and resistant, respectively): KB-3-1 and KB-8-5-11 (ABCB1, also... . To determine if [3 H]PK 11195 and [3 H]PBR28 were substrates of ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health

 

Collection: Biology and Medicine

 
44 Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal
 

Summary:  | efflux The efflux transporter P-glycoprotein (P-gp; encoded by ABCB1) blocks the entry of various... -gp and BCRP KO [mdr1a(-/-) , mdr1b(-/-) , bcrp(-/-) ] mice (25, 26). In a situation in which a weak base [11 C... to elucidate the mechanism of transport by ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
45 doi:10.1006/scdb.2001.0250, available online at http://www.idealibrary.com on seminars in CELL & DEVELOPMENTAL BIOLOGY, Vol. 0, 2001: pp. 110
 

Summary:  cancers express the MDR1 gene at levels sufficient to confer multidrug resistance. In fact, based... cancers will express the MDR1 gene at some time during therapy.15 (Details about the cloning and genetic... and the expression of human ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
46 AnmtRev, Genct.1995, 29:607-49 Copyright1995by AnnualReviewsInc. All rights reserved
 

Summary:  cells. The MDR1 gene, which encodes P-gp, is expressed at levels thought to be physiologically... , 232, 233). Basedon expression the humanMDR1genein transportingepithelia of the liver, kidney... newinhibitors and reversing agents. PRETRANSLATIONALREGULATIONOF ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
47 UNIVERSIT PARIS XI FACULT DE PHARMACIE DE CHTENAY-MALABRY
 

Summary:  2-5- Régulation du gène mdr1 73 3- La sous-famille MRP (Multidrug Resistance associated Proteins) 75... - Transporteurs ABC et VIH 81 5-1- Effet de l'infection par le VIH sur l'expression des transporteurs 81 tel... -2- Effet inhibiteur des antirétroviraux sur les transporteurs ABC 86 6-3- Effet des antirétroviraux sur ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
48 Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal
 

Summary:  | efflux The efflux transporter P-glycoprotein (P-gp; encoded by ABCB1) blocks the entry of various... -gp and BCRP KO [mdr1a(-/-) , mdr1b(-/-) , bcrp(-/-) ] mice (25, 26). In a situation in which a weak base [11 C... to elucidate the mechanism of transport by ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
49 Genetic variation in putative regulatory loci controlling gene expression in breast cancer
 

Summary:  the set of transcripts associated with SNPs in ABCB1, BAK, AKT2, and ABCC1 genes. ABCB1 (MDR1) is strongly... with genetic variants of ABCB1 (Table 10, which is published as supporting information on the PNAS web site... in ...

  

Source: Sharan, Roded - School of Computer Science, Tel Aviv University

 

Collection: Computer Technologies and Information Sciences

 
50 assembled many cell generations earlier. In con-trast, the daughter centrosome migrates away
 

Summary:  .1126/science.1135774 A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity Chava Kimchi... in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1... the structure of substrate and inhibitor ...

  

Source: Juelicher, Frank - Max-Planck-Institut für Physik komplexer Systeme

 

Collection: Biology and Medicine ; Physics

 
51 Summary and outlook H. Bart van den Berg van Saparoea and Arnold J.M. Driessen
 

Summary:  fermentation in wine making, #12;80 and MDR1 (ABCB1 or P-glycoprotein), a human MDR protein. The presence... superfamily that acts as a drug/H+ antiporter. When expressed in Escherichia coli or in human lung fibroblast... , and human tumor cells) increase the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
52 Chemistry and Physics of Lipids 141 (2006) 119132 Proteins involved in lipid translocation in eukaryotic cells
 

Summary:  a floppase activity in epithelial cells expressing MDR1or MDR3 (now named, respectively, ABCB1 and ABCB4... (2003) -idem ABCA1 PS, chol. Yes Hamon et al. (2000) Mice erythrocytes ABCB1 P-glycoprotein ...

  

Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques

 

Collection: Chemistry ; Biology and Medicine

 
53 P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with
 

Summary:  -glycoprotein. Neuropharmacology. 2008;55:1364­ 1375. 5. Jamroziak K, Robak T. Pharmacogenomics of MDR1/ABCB1 gene: the influence... studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... found that dLop is ...

  

Source: McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health

 

Collection: Biology and Medicine

 
54 Annu. Rev. Pharmacol. Toxicol. 1999. 39:36198 BIOCHEMICAL, CELLULAR,
 

Summary:  of P-gp (39). In this system, the wild-type or mutant MDR1 cDNAs constructed in an expression plasmid... mdr1a and mdr1b cDNAs (5), and of human MDR1 cDNA (6) in cultured cells and in mouse bone marrow ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
55 Effect of a P-Glycoprotein Inhibitor, Cyclosporin A, on the Disposition in
 

Summary:  23:1096­1112. Ieiri I, Takane H, Otsubo K. 2004. The MDR1 (ABCB1) gene poly- morphism and its... -gp knockout mice (mdr-1a/1b(À/À)) (Schinkel et al., 1994) (model 001487-MM, double homozygotes) and wild type... mice ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
56 Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic
 

Summary:  and adrenal glands were low or even absent (Table 4). The efflux transporter mdr1a was highly expressed... , mrp2 was expressed at significant levels. Mdr1b is highly detected in the adrenal glands (Table 5... Glands ++++ ++++ ++++ - ++++ ++++ ++++ - Table 5. Relative ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
57 P19. GENE THERAPEUTIC OVEREXPRESSION OF MDR1 RESULTS IN UPREGULATION OF FURTHER GENES INVOLVED
 

Summary:  - and radio- therapy of P-gp-expressing tumors. However, little is known about the influence of MDR1... -one annotated genes showed a significant change in expression (p < 10À4 ) in MDR1-overexpressing compared... P19. GENE THERAPEUTIC OVEREXPRESSION OF ...

  

Source: Granada, Universidad de - Departamento de Ciencias de la Computación e Inteligencia Artificial, Soft Computing and Intelligent Information Systems

 

Collection: Computer Technologies and Information Sciences

 
58 The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor
 

Summary:  ., 2005). Furthermore, in LS180 cells, SFN inhibited RIF- or RU486-induced expression of MDR1 (ABCB1... inhibiting SXR-mediated CYP3A4 and MDR1 gene expression. SFN has also been shown to inhibit histone... -detoxifying enzymes ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
59 ABC transporters ABC transporter architecture and regulatory roles of
 

Summary:  -glycoprotein (P-gp/MDR1/ABCB1) activity. Irrespective of the direction of transport (uptake or excretion... /3), human peptide transporter; PDR5, yeast pleiotropic drug resistance transporter; P-gp (MDR1/ABCB1), human... ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
60 Sp3 Represses Gene Expression via the Titration of Promoter-specific Transcription Factors*
 

Summary:  , the ectopic expression of Sp3 in Drosophila SL2 cells stimulated transcription of the DHFR, p21, and MDR-1... of three Sp-regulated promoters: DHFR, p21, and MDR-1. Additionally, we examined each of these mutated... was subcloned in plasmid pRL (Promega, Inc., Madison, WI). pgpLuc-B ...

  

Source: Horowitz, Jonathan M. - Department of Molecular Biomedical Sciences, North Carolina State University

 

Collection: Biology and Medicine


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61 Steroid and Xenobiotic Receptor SXR Mediates Vitamin K2-activated Transcription of Extracellular Matrix-related Genes
 

Summary:  B or multidrug resist- ance 1 (MDR1) (20) was most significantly up-regulated by either vitamin K2... Gene symbol Description -Fold increase over control Vitamin K2 RIF 209994_s_at ENSG00000085563 ABCB1... ATP-binding cassette, subfamily B (MDR/TAP), member 1 6.06 4.29 209993_at ENSG00000085563 ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
62 In vitro methods to study intestinal drug metabolism
 

Summary:  transporters increase (MDR1 (Pgp/ABCB1) [17-19], MRP1 (ABCC1 [19]), OCTN2 [20]), decrease (BCRP (ABCG2 [21... of drug metabolism and enzyme 48 expression in vitro 3.5.1. Individual parameters influencing drug... . This is supported by the demonstration of high ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
63 Expression Levels and Activation of a PXR Variant Are Directly Related to Drug Resistance in
 

Summary:  analysis. Figure 1B shows the baseline expression of P450 3A4 and MDR1 mRNA in COL and OS187 osteosarcoma... that osteosarcoma cell line COL expresses higher levels of P450 3A4 and less MDR1 mRNA than OS187. Expression... that in the osteo- ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine; Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
64 Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric Dimers
 

Summary:  MDR1 and PDR5 are flanked by SacII restriction enzyme sites for cloning into the ABCG2-ABCG2 construct... 1/ABCB1), chosen because it shares many of the same transport substrates as ABCG2. The third... were expressed at the plasma membrane and maintained drug ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
65 A. HEMBURY BHE et ET-1 : REGULATION des TRANSPORTEURS ABC et des CYTOKINES INFLAMMATOIRES UNIVERSIT PARIS-SUD 11
 

Summary:  INFLAMMATOIRES - 10 - MCP-1 Monocyte chemoattractant protein 1 ( = MCAF = CCL2) MDR1 Multidrug resistance MMP... Figure 11 : Quelques uns des facteurs modulant la transcription du gène MDR1 codant pour la Pgp. Page 38... Figure 12 : Schéma bidimensionnel de la partie 5' de l'ARNm de ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
66 Singular measures of circle homeomorphisms with two breakpoints 1
 

Summary:  ((l), (p), z(p)) tends to 1 as (l), (p) tend to . Recall that abcb = 1 by assumption. Next we discuss... the conditions under which the expression 1(z(p))2((l), (p), z(p)) stays away from 1. Obviously |12 - 1| = |(1... interval is 4ev-comparable with dn. In complete analogy we can estimate the second ...

  

Source: Liousse, Isabelle - Laboratoire Paul Painlevé, Université de Lille

 

Collection: Mathematics

 
67 Abstract. The typically distinct phospholipid composi-tion of the two leaflets of a membrane bilayer is generated
 

Summary:  transporter ABCB1 translocated a wide variety of short chain lipids [110­113], including the short chain PC... the outward orientation of natural choline phospholipids to the PM [116­119]. However, whether ABCB1 and -C1... leaflet. This type of mechanism is supported by a few studies on natural long chain ...

  

Source: Menon, Anant K. - Menon Lab, Weill Medical College, Cornell University

 

Collection: Biology and Medicine

 
68 Anesthesiology 2005; 102:5506 2005 American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins, Inc. Pharmacogenetic Determinants of Human Liver
 

Summary:  and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose re- quirements and trough blood levels... , van Gelder T: Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics... is related to CYP3A5 and ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
69 tel-00628629,version1-3Oct2011 tel-00628629,version1-3Oct2011
 

Summary:  'enzyme de désactivation UGT1A1, et les quatre transporteurs ABCB1, ABCC1, ABCC2, ABCG2. Au contraire, l'expression... consiste à optimiser la thérapie en fonction des profils d'expression de gènes des cellules saines et... - cadien (CT) 0, des rythmes circadiens d'une période de 26 h 50 (SD 63 min) ont ...

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
70 Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes in
 

Summary:  for cystic fibrosis.6 Some ABC proteins, such as MDR1 (ABCB1), MRP1 (ABCC1) and BCRP (ABCG2), are commonly... Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes... expression is more frequently seen from fusions to ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
71 Modlisation de la Leucmie Mylode Chronique (http://www.math.u-
 

Summary:  dans cette pathologie a été celui médié par la P-glycoprotéine (ABCB1/MDR1) une ABC (ATP Binding... show that it is possible to express both the number and rate with which hematopoietic stem cells... chimiothérapies, corrélations entre expression, ...

  

Source: Pujo-Menjouet, Laurent - Institut Camille Jordan, Université Claude Bernard Lyon-I

 

Collection: Mathematics ; Biology and Medicine

 
72 RESEARCH Open Access Pregnane Receptor (PXR) expression in
 

Summary:  metabolites are subjected to extracellular efflux through transporters, including P- glycoprotein (MDR1... ]. Targets genes of PXR are CYP3A4 [14], MDR1 [15], CYP2B6 [16], members of UGTs superfamily [17... pharmacological inhibitors of CYP3A4 (ketoconazole), MDR1 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
73 The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
 

Summary:  -binding domain; LXR: liver X receptor; MDR1: multidrug resistance protein-1; NR: nuclear receptor; PAR: pregnane... ) and sulfotransferase (SULT)) and ABC family transporters such as MDR1 and MRP2 [Dussault et al., 2001; Synold et al... that are secondary to SXR-mediated induction of drug clearance via ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
74 11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain
 

Summary:  , as described previously (20). PET Studies on Mice Three knockout mice (28 6 5 g; mdr-1a/b2/2; model 001487- MM... , double homozygotes) (21) and 3 wild-type mice (31 6 2 g; mdr-1a/b1/1; model FVB) were anesthetized with 1... . Association of multidrug resistance in epilepsy with a polymorphism in the ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
75 10.1177/0091270003262075ARTICLEKHARASCH ET ALFENTANYL AND P-GLYCOPROTEINDRUG METABOLISM Quinidine as a Probe for the Role of
 

Summary:  but not fentanyl behaved as a P-gp sub- strate in L-MDR1 cells expressing P-gp, both fentanyl and loperamide... , there was substan- tial loperamide transport in L-MDR1 cells expressing human P-gp, while fentanyl was a relatively... cell line ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
76 Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus)
 

Summary:  ; psc833; mk571; Calcein-am; SpABCB1; SpABCC1; SpABCC2; Mitosis Introduction Fertilization results... Biosystems, Foster City, CA). SpABCB1 primer sequences were forward 5VGGAGCTTGAGAAGCATTTCAGC3Vand reverse 5... relative to human and invertebrate mdr proteins. ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
77 353 . 9 4 2 0 0 7 , 0,52%
 

Summary:  ]. - , - . - , , - . ' - - , - . - (P-gp) -- - , - (multidrug resistance gene -- MDR-1... ) - , - , , - , , , - [5, 6]. P-gp - (). - ( , - , , - ) , . [7] MDR-1 (P-gp), Ki... - . MDR+ - ...

  

Source: Mykytenko, Dmytro - R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine

 

Collection: Biology and Medicine

 
78 Seminars in Immunology 15 (2003) 257270 Chemokine regulation of naive T cell traffic in health and disease
 

Summary:  transporter Abcb1 (MDR-1, P-glycoprotein) and the leukotriene C4 transporter Abcc1 (MRP-1 [95]). Blocking... either of these channels with pharmacologic in- hibitors or using T cells from Abcb1 or Abcc1-deficient... leukotrienes. Thus, a model of sequential ...

  

Source: von Andrian, Ulrich H. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
79 Genes and proteins: Dogmas in decline A long-standing assumption of modern biology is the fidelity of the genotype-phenotype relationship.
 

Summary:  (MDR1) gene], an ATP-driven efflux pump of the plasma membrane involved in the multidrug resistance... , or wild-type, allelic sequence of MDR1 exhibited reduced transport functionality of P-gp. There were... ) with other, function- impairing, non-synonymous SNPs in the ...

  

Source: Newman, Stuart A. - Department of Cell Biology and Anatomy, New York Medical College

 

Collection: Biology and Medicine

 
80 Title: Neurocognitive Effects of Chemotherapy and Endocrine Therapies in the Treatment of Breast Cancer: Recent Perspectives
 

Summary:  homozygous for this allele demonstrate significantly lower MDR-1 expression and decreased P-gp functionality... of multidrug resistant-1 (MDR-1) gene and the functionality of the protein [114]. Several polymorphisms... of the gene that encodes for P-gp, ...

  

Source: Kalueff, Allan V. - Department of Pharmacology, Tulane University

 

Collection: Biology and Medicine


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81 A survey of integral a-helical membrane proteins Libusha Kelly Ursula Pieper Narayanan Eswar
 

Summary:  the rationale for their inclusion into the target list. In humans, ABCB1 (also known as MDR1) and other members... as in the human transporters ABCB1, ABCB11 and ABCB4 (Supplemen- tary Fig. 2). The most similar structurally... cloned, expressed, ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
82 Both ATP Sites of Human P-Glycoprotein Are Essential but Not Symmetric Christine A. Hrycyna, Muralidhara Ramachandra,,| Ursula A. Germann,, Priscilla Wu Cheng,, Ira Pastan, and
 

Summary:  protein encoded by the MDR1 gene (3). It is composed of two homologous halves, each containing six... . Specific point mutations were constructed by sequence overlap PCR methodology using pTM1-MDR1 (wild... . The product and the pTM1-MDR1 parent vector were digested ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
83 Lipid rafts : dream or reality for cholesterol transporters ? Stphane ORLOWSKI1
 

Summary:  ) model ABC transporter for relationships with cholesterol P-glycoprotein (P-gp = ABCB1) is well... regulation based on cholesterol- sensitive nuclear factors controling the expression level of lipid transport... controling the expression level of lipid transport proteins. Indeed, the cell plasma membrane is ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
84 Functional Characterization of Glycosylation-Deficient Human P-Glycoprotein Using A Vaccinia Virus Expression System
 

Summary:  into the pBAC-MDR1(H6) transfer vector for the baculovirus expression system (Ramachandra et al., 1998... -MDR1(H6) (Ra- machandra et al., 1998) plasmid for the vaccinia virus expression sys- tem, which... -deficient P-gp expression. HeLa cells ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
85 Effect of CYP2C19 polymorphism on nelfinavir to M8 biotransformation in HIV patients.
 

Summary:  no difference in nelfinavir concentrations between patients with these different genotypes. However, for MDR1... compared to *1/*1 patients. We did not evidence any influence of MDR1 polymorphism on nelfinavir absorption... , 2C19 and MDR1 was performed. A population ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
86 When the inherent redundancy of the genetic code was discovered, scientists were rightly puzzled by the
 

Summary:  in the human multidrug-resistance protein 1 (MDR1) gene was proposed to influence mRNA stability106 or protein... codon-usage bias (FIG. 1), is now recognized as cru- cial in shaping gene expression and cellular... - tant in applied settings as well -- the use of particular codons can increase the expression

  

Source: Plotkin, Joshua B. - Department of Biology, University of Pennsylvania

 

Collection: Biology and Medicine

 
87 Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption
 

Summary:  'graggen K, Volk C, Hoffmann MM, Haefeli WE & Weiss J 2005 Expression of the drug transporters MDR1/ABCB1... murine ortholog pregnane X receptor (PXR) are nuclear receptors that are expressed mainly in the liver... substances, pharmaceutical agents, and xenobiotic ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
88 456 EUKARYOTICABC TRANSPORTERS [33] [33] Functional Expression of Human P-Glycoprotein
 

Summary:  sites and main features of the expression plasmid pTMI-MDR1are shown. In this vector, MDR1is controlled... sequence of MDR1 isolated from pMDRXS(WT) by digesting with the same enzymes. The resultant expression... ] A B Xbal ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
89 Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.106.066720
 

Summary:  ABCB subfamily contains a well-studied member, ABCB1/MDR1/PGP-1, which is involved in multiple drug... -likeORFwasfoundbetweenbrF22E10.2andbrF22E10.3;areversetranscriptase-likeORFwasfoundbetweenbrABCB.1andbrABCB.2. i... and Kanehisa 2000). C. elegans ABC genes are ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
90 Bivalent Probes of the Human Multidrug Transporter P-Glycoprotein Marcos M. Pires, Christine A. Hrycyna,* and Jean Chmielewski*
 

Summary:  ., Ambudkar, S. V., Pastan, I., and Dey, S. (1998) HIV-1 protease inhibitors are substrates for the MDR1... protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein, Cancer Res... as a strategy for enhanc- ing the efficacy of P-glycoprotein ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
91 TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES
 

Summary:  ) and multidrug resistance protein-1 (MDR1), but not CYP3A4 expression, in intestinal LS180 cells. We found... II UGT1A1 or phase III MDR1 gene expression after treatment with tocotrienols or RIF. In contrast... , tocotrienols activate SXR and induce CYP3A4 ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
92 pour obtenir le titre de DOCTEUR de l'ECOLE POLYTECHNIQUE
 

Summary:  -gp /MDR1 /ABCB1, MRP1 /ABCC1) (Chen et al., 1986, Cole et al., 1992). Quelques maladies parasitaires... CD Escherichia coli transporteur de la vitamine B12 3,2 Å - 1l7v Locher et al., 2002 P-gp (MDR1) Cricetulus... ., 2005 P-gp ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
93 Population genomics of drug resistance in Candida albicans
 

Summary:  expression, both of which include up-regulation of the multidrug major facilitator transporter gene, MDR1... in expression of numerous genes in addition to a known resistance determinant, MDR1. One gene... in the microarray experiments (ADH4, ...

  

Source: Anderson, James B. - Department of Ecology and Evolutionary Biology, University of Toronto; Kohn, Linda M. - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
94 Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State
 

Summary:  with enhanced expression of the human multidrug resistance gene (MDR1) (1, 2). The MDR1 gene encodes a 170 k... transfected with MDR1, without preexposure to cytotoxic drugs (14), membrane vesicles from multidrug resistant... recombinant DNA ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
95 Global Weak Solutions to a Mathematical Model Using Aptamers in Chemotherapy and Imaging
 

Summary:  .M. Cherry, J.M. Brown, and B.I. Sikic, Preferential expression of a mutant allele of the amplified MDR1... (ABCB1) gene in drug-resistant variants of a human sarcoma,Genes Chromosomes Cancer, 34, 372-83, (2002... of MDCKII-hMDR1 cells, ...

  

Source: École Polytechnique, Centre de Mathématique Appliquées

 

Collection: Mathematics

 
96 Principal Investigator/Program Director (Last, First, Middle): Juliano, R.L. PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page
 

Summary:  Aerschot A, Abramov M, Xu D, Juliano R, Herdewijn P. Inhibition of MDR1 expression with altritol modified... , Miyamoto YJ, Marchand A, Van Aerschot A, Herdewijn P, Juliano RL. Inhibition of MDR1 gene expression... RL. Strategies for the inhibition of ...

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
97 Introduction Breast cancer growth is regulated by estrogen, which acts
 

Summary:  -transferase mu 3 GSTT1 NM_000853 22q11.23 Glutathion S-transferase theta 1 Phase III proteins ABCB1 NM_000927 7q... 21.1 ATP-binding cassette, subfamily B (MDR/TAP), member 1 (MDR1) ABCC1 NM_004996 16p13.1 ATP... .0­2.3 0.4 ± 0.3 0.1­0.7 0.6 ± 0.6 0.0­2.2 NS NS ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
98 B-1 Cell Lymphoma in Mice Lacking the Steroid and Xenobiotic Receptor, SXR
 

Summary:  , Hoffmann MM, Haefeli WE, Weiss J 2005 Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC... hormone receptor that is highly expressed in the liver and intestine, where its primary function... is to regulate drug and xenobiotic metabolism. SXR is ...

  

Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine

 

Collection: Biology and Medicine

 
99 Endocrinology 2006 147:2357-2367 originally published online Feb 16, 2006; , doi: 10.1210/en.2005-1526 Quaid Morris
 

Summary:  -3- 0.62 0.08 (60) Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B 0.65 0.08 (61) Fdxr... ) (Ref. 73) Scarb1 Scavenger receptor class B, member 1 1.94 0.08 (Ref. 74) (Ref. 74) Abcb1b ATP... . Schimmer and Adrenal Cells Global Profiles of Gene Expression Induced by ...

  

Source: Morris, Quaid - Department of Electrical and Computer Engineering, University of Toronto

 

Collection: Computer Technologies and Information Sciences

 
100 Annu. Rev. Ecol. Evol. Syst. 2005. 36:16989 doi: 10.1146/annurev.ecolsys.36.102003.152617
 

Summary:  , by opposing their absorption, hastening their excretion, and protecting the brain. For example, mdr1a knockout... expressed on the apical surface of cells in the lower intestine with increasing levels from the duodenum... and many PSMs. It is expressed in large amounts in liver cells but also in intestinal ...

  

Source: Foley, Bill - School of Botany and Zoology, Australian National University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine


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