| Sample search results for: a2 receptor targeting |
| 1 | In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to | ||
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Summary: activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... and 4 the yeast system is exploited to study inverse agonism of the human adenosine A2B receptor... . At first, constitutively active ... |
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Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden |
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Collection: Physics |
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| 2 | This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the | ||
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Summary: Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... are ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 3 | J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0 | ||
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Summary: for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 ago... - nists) and depression (galanin receptor antagonists). The A2A=D2, ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 4 | JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004 | ||
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Summary: brain regions, including dopa- mine target areas that express D1 and/or D5 receptors... effects may be state dependent. If the target cell is in a depolarized state, then D1 receptor stimulation... . Both receptor subtypes can activate kinases that target specific ... |
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Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University |
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Collection: Biology and Medicine |
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| 5 | P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a | ||
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Summary: P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of receptors... , termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 6 | Enhancement of the surface expression of G protein-coupled receptors | ||
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Summary: -opioid [47] and prostaglandin EP3 receptors [48], RACK1, which enhances trafficking of thromboxane A2... receptors [49], Usp4, which increases plasma membrane expression of adenosine A2A receptors [50], ATBP50... . (2008) RACK1 regulates the cell ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 7 | John Bonner ~ 1950 Spirals and Targets in Dictyostelium | ||
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Summary: system in Dictyostelium Receptor activity, time externalcAMP A A I I k~ A2 slow slow Active Active Active... 1 John Bonner ~ 1950 Spirals and Targets in Dictyostelium #12;2 #12;3 A A I I The cAMP receptor... cycle slow slow fastfast k~ A2 A A I I ... |
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Source: Moehlis, Jeff - Department of Mechanical and Environmental Engineering, University of California at Santa Barbara |
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Collection: Physics |
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| 8 | DOI: 10.1113/jphysiol.2007.131367 2007;581;3-; originally published online Mar 22, 2007;J. Physiol. | ||
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Summary: (Burzomato C AC A2C A3C AF A2F A3F AO A2O A3O CLOSED FLIPPED OPEN C AC A2C A3C AF A2F A3F AO A2O A3O C AC ... |
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Source: Colquhoun, David - Department of Pharmacology, University College London |
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Collection: Biology and Medicine |
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| 9 | AMPA receptor desensitization mutation results in severe developmental phenotypes and early | ||
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Summary: in the GluA2 (GluR2) receptor subunit (GluA2L483Y ). This mutation was homozygous lethal. However, mice... receptor subunits GluA1 and GluA2 was decreased, whereas NMDA receptor protein expression was ... |
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Source: Contractor, Anis - Department of Physiology, Northwestern University |
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Collection: Biology and Medicine |
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| 10 | Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance | ||
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Summary: , Benedetti Pd P, et al. (2004) Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro... GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 11 | Architectural and Structural Optimization of the Protective Polymer Layer for Enhanced Targeting | ||
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Summary: functional groups and efficiency of receptor targeting. Two types of receptor surfaces were considered... the high efficiency of receptor targeting by bidisperse polymer layers, which is achieved by means... the functional targeting groups and cell ... |
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Source: Dormidontova, Elena E. - Department of Macromolecular Science and Engineering, Case Western Reserve University |
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Collection: Engineering ; Materials Science |
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| 12 | Richard Huganir () DirectorDepartment of Neuroscience, Howard Hughes Medical Institute, | ||
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Summary: properties of these receptors including conduct ance and membrane targeting. Recent studies in our lab have... are critical in the proper membrane trafficking and synaptic targeting of these receptors. We have recently... Hopkins University School of Medicine Receptors, Synapses and ... |
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Source: Miyashita, Yasushi - Department of Physiology, University of Tokyo |
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Collection: Biology and Medicine |
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| 13 | Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle | ||
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Summary: A2A receptors in fibrosis in tissues outside of the skin is less clear... . Prior studies have demonstrated that adenosine A2B receptors regulate production... to the nucleus thereby promoting fatty ... |
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Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University |
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Collection: Biology and Medicine |
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| 14 | Brain Research 869 (2000) 178185 www.elsevier.com/locate/bres | ||
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Summary: and methods 5-HT , 5-HT , 5-HT and dopamine receptors showed2A 2C 7 that the wild-type mice, but not the 5-HT... nuclei, 5-HT -immunoreactivity was co-5A 5a [2]. The immunoreactivity was visualized using the ABC... serotonin for which the target sites and stimulation ... |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 15 | Interneuron Diversity series Diversity of inhibitory | ||
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Summary: -positive interneurons innervate somatic GABAA receptors with a large a1:a2 subunit ratio [35]. This clear segregation... , 1193911944 34 Nyiri, G. et al. (2001) Input-dependent synaptic targeting of a2-subunit- containing... be affected by the anchoring and ... |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 16 | Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins | ||
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Summary: in the A2b receptor recruitment to the membrane, we investigated the possible role of putative vesicle-targeting... July 15, 2004; doi:10.1152/ ajpgi.00164.2004.--Adenosine, acting through the A2b receptor, in- duces... in the recruitment of the ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 17 | Current Pharmaceutical Design, 2004, 10, 000-000 1 1381-6128/04 $45.00+.00 2004 Bentham Science Publishers Ltd. | ||
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Summary: rapid release of arachidonic acid in monocytes by activation of phospholipase A2 in a calcium dependent... and PTX-sensitive manner [28]. Activation of phospholipase A2 is involved in monocyte polarization... and chemotaxis induced by MCP-1 because this effect is blocked by inhibitors of phospholipase ... |
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Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences |
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Collection: Biology and Medicine |
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| 18 | Diffusion-Dependent Mechanisms of Receptor Engagement and Viral Entry Melissa M. Gibbons, | ||
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Summary: in units of a, the radius of the virus spike-cell membrane contact area, and time in units of a2 /p... a , tj ) tp a2 , cj(rj, tj) ) a2 c(r, t) Dj ) D p , qj ) qa2 p , ¯in ) ina2 p , µ¯n ) µna2 p (11) - j)1 N... Diffusion-Dependent Mechanisms of ... |
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Source: D'Orsogna, Maria Rita - Department of Mathematics, California State University, Northridge |
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Collection: Mathematics |
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| 19 | The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine | ||
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Summary: disorders, highlighting specific purinergic receptor subtypes, most notably A2A , P2X4 and P2X7 ,that might... in rodents, which is antagonised by caffeine. A2A receptors in the nucleus accumbens mediate this locomotor... . expression of ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 20 | An escort for GPCRs: implications for regulation of receptor density at the cell Lamia Achour1,2 | ||
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Summary: for Activated C-Kinase 1)71 . RACK1 is an ER protein that constitutively binds the thromboxane A2 receptor (TPß... surface expression of the G protein- coupled receptor for thromboxane A(2). Traffic 9, 394-407 72. Chen, C... functional cell surface ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 21 | Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach | ||
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Summary: , as discussed below, ifenprodil not only affects NR1/NR2B receptors but also triheteromeric NR1/2A/2B receptors... (5):13311333 Neyton and Paoletti · Commentary #12;receptors are present in the cortex and hippocampus and NR1/2A/2C... ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 22 | nature neuroscience volume 1 no 7 november 1998 563 Nervous system signaling depends on the spatially and tempo- | ||
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Summary: almost completely colocalized with punctate staining of the GABAA receptor 2 (Fig. 5a), 2 (Fig. 5c) or 1... subunit in brain and is incorporated in most GABAA receptor subtypes. Neonatal mice with a targeted... targeting and synaptic clus- tering of GABAA ... |
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Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 23 | Olfactory receptor trafficking to the plasma membrane C. F. Bush and R. A. Hall* | ||
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Summary: A2a receptors, were all found to signifi- cantly enhance the plasma membrane localization of M71... performed in heterologous cells and it is not clear whether b2-adrenergic, P2Y1, P2Y2, and A2a receptors... of b2-adrenergic, P2Y1, P2Y2, and ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 24 | Purine and pyrimidine receptors G. Burnstock | ||
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Summary: by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 25 | Purine and pyrimidine receptors G. Burnstock | ||
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Summary: , complementary DNAs (cDNAs) encoding two different P1 receptor subtypes (A1 and A2) were isolated [20], and... , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 26 | REVIEW ARTICLE Chemokine receptors and other G protein-coupled receptors | ||
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Summary: of invertebrate rhodopsin, b1-adrenergic and b2-adrenergic receptors and the A2A-adenosine receptor have been... -adrenergic and b2-adrenergic receptors, and most recently, the structure of the A2A adenosine receptor [26... ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 27 | Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd. | ||
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Summary: to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors... 1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... on sensory ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 28 | NMDA receptor subunit gating uncovered Alasdair J. Gibb | ||
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Summary: and Jahr [16], oscillation into and out of a rela- tively long-lived shut state, A2RD (desensitized state... and Traynelis [1]. Two new states, A2Rf and A2Rs, reflect the fast gating transitions of the NR1 subunits (kþf... order to arrive at the ... |
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Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 29 | Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK | ||
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Summary: receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... . Blockade of A2A (P1) receptors antagonises parkinsonian tremor in the rat tacrine model by actions... on specific ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 30 | ELSEVIER Immunopharmacology33 (1996) 9-15 Immunophannacology | ||
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Summary: produce pathophysiologic quantities of mediators such as TxA 2, independent of BK receptor mechanisms... receptor-mediated activationof phospholipaseA2 in 3T3 fi- broblasts. Proc. Natl. Acad. Sci. USA 1988... . Bradykinin (BK) represents such a versatile ... |
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Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 31 | Associate editor: A.L. Morrow Regulation of GABAA receptor trafficking, channel activity, | ||
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Summary: -deficient mice (Gu¨n- ther et al., 1995). Clustering of a1 and a2 subunit-containing receptor subtypes is reduced... ;rescues clustering of a1 and a2 subunit-containing receptors in the cerebellum and hippocampus... - containing receptors mediate ... |
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Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 32 | ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and | ||
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Summary: were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being investigated... , ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 33 | Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal & | ||
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Summary: to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... to A1 and A2 types were identified in human foetal astrocytes [68]. In these cells, the A1 receptors... inhibited, whereas ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 34 | The International Journal of Biochemistry & Cell Biology 35 (2003) 130134 Molecules in focus | ||
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Summary: of the ephrinA2, ephrinA5, EphA2, EphA5, and EphA6 proteins in the retina and the superior collicu- lus (or... maintained by ephrinA2 and ephrinA5 signals [2]. Recent studies demonstrate that class-B Ephs and ephrins... receptors and ephrins ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 35 | Neurons respond to a variety of attractive and repulsive guid-ance cues to navigate to their targets1. Genetic, biochemical and | ||
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Summary: . Nasal axons express ephrin-A2 and ephrin-A5 as well as a moderate level of Eph receptors... with the metalloprotease kuzbanian, which triggers cleavage of ephrin- A2 upon Eph receptor binding. When cleavage... 92. A second proposed netrin ... |
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Source: Bargmann, Cori - Laboratory of Neural Circuits and Behavior, Rockefeller University |
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Collection: Biology and Medicine |
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| 36 | TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6 | ||
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Summary: , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... A2 receptors; however, it might also act (broken arrow) to potentiate P2X3 or P2X2/3 activation... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 37 | The serotonergic system The Serotonergic System | ||
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Summary: . Phospholipase A2 (PLA2) In the early literature, it was found that 5-HT stimulates the activity PLA2... modulation of the limbic system 5. Serotonin receptor subtypes 6. Signal transduction pathways 7. Clinical... significance of 5-HT receptors 8. Effects of serotonin on behaviour 9. ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 38 | Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking* | ||
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Summary: constructs were kindly provided by Ken Minneman (Emory University School of Medicine). 2A-, 2B-, and 2C... Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking... inhibitory signaling in the brain via stimula- tion of both GABAA receptors (GABAAR), ... |
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Source: Teissére, Jeremy Alden - Biology Department, Muhlenberg College |
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Collection: Biology and Medicine |
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| 39 | Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking* | ||
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Summary: by Ken Minneman (Emory University School of Medicine). 2A-, 2B-, and 2C-adrenergic receptor constructs... Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking... inhibitory signaling in the brain via stimula- tion of both GABAA ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 40 | Transmembrane signalling and the aspartate receptor William G Scott1 and Barry LStoddard 2* | ||
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Summary: by calculating the total buried surface area in the coiled coil model (-1800 A2 ), the number of side chain... Transmembrane signalling and the aspartate receptor William G Scott1 and Barry LStoddard 2* 1 MRC... Center, 1124 Columbia Street, Seattle, Washington 98104, USA Background: The aspartate receptor |
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Source: Scott, William - Department of Chemistry and Biochemistry, University of California at Santa Cruz |
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Collection: Chemistry |
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| 41 | Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and | ||
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Summary: this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... Function The use of mice deficient in a targeted receptor (knockouts) is a useful way in which to assess... (DRG) and represent unique ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 42 | EDITED B'r' Bertha K. Madras Harvard Medical School | ||
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Summary: , and serotonin (5-HT3) receptors. Currently, 12 neu- ronal nAChR subunits have been identified (a2--a1 0 and 132... nicotinic acetylcholine receptor: structure and localization. (A) Topology of a single subunit (a2-al 0; 132... in the reg- ulation of nicotinic ... |
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Source: Lester, Henry - Division of Biology, California Institute of Technology |
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Collection: Biology and Medicine |
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| 43 | Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd. | ||
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Summary: of what is known of the distribution and roles of these receptor subtypes. Potential therapeutic targets... activate phospholipases A2, C and D, MEP/MAP kinase, Rho-dependent kinase and tyrosine kinase, as well... and visceral organs represent unique targets for novel analgesic agents ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 44 | 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001) | ||
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Summary: were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... receptors on osteoblasts and osteoclasts: potential targets for drug development. Drug Dev Res 49... of skeletal muscle, changes in ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 45 | UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors | ||
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Summary: . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... nucleotide receptors and target individual enzyme isoforms. Together these studies will provide both... UCB ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 46 | G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins in vertebrates and they | ||
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Summary: -specific protein 1; T2R, taste receptor type 2; TM, transmembrane; TXA2R, thromboxane A2 receptor; USP4, ubiquitin... receptor (OPR) promotes the endocytic targeting of agonist-internalized OPRs to lysosomes, where... associate with nHERF1 are ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 47 | PATTERNS & PHENOTYPES Abundant and Dynamic Expression of G Protein- | ||
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Summary: - riety of signal transduction pathways, involving protein kinase C, phospho- lipase A2, and the mitogen... PATTERNS & PHENOTYPES Abundant and Dynamic Expression of G Protein- Coupled P2Y Receptors... diverse biological effects by activating two families of receptors, the P2X and P2Y ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 48 | doi:10.1152/ajpgi.00147.2006 291:605-610, 2006. First published May 4, 2006;Am J Physiol Gastrointest Liver Physiol | ||
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Summary: receptor types on target cells complicates the analysis of signaling pathways, in partic- ular... 50: 870877, 1996. 23. Murthy KS, McHenry L, Grider JR, and Makhlouf GM. Adenosine A1 and A2b... in smooth muscle by receptor silencing and receptor ... |
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Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University |
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Collection: Biology and Medicine |
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| 49 | Provided for non-commercial research and educational use only. Not for reproduction, distribution or commercial use. | ||
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Summary: pathway for diffusible ligands. The structure of an engi- neered human A2A adenosine receptor in complex... 13], engineered expressed monoaminergic turkey 1AR [14], engineered expressed human A2A adenosine receptor [15... engineered human ... |
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Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University |
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Collection: Biology and Medicine |
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| 50 | The role of ephrins and Eph receptors in cancer Hanna Surawska, Patrick C. Ma, Ravi Salgia* | ||
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Summary: -A Eph receptor regulation of pathogenic angiogenesis in tumors. EphA2 has been implicated in VEGF... and invasiveness of EphA2-transformed cells. According to Ruoslahti et al., overexpression of the receptor does... of EphA2, ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 51 | The state of GPCR research in 2004 (20 Questions) Nat Rev Drug Discov. 2004 Jul;3(7):575, 577-626. | ||
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Summary: AMP production in discrete brain areas, and discovered a number of receptors, including adenosine A2 receptors... as therapeutic targets? Many predictions for heptahelical receptors have been based on using the 592 rhodopsin... ... |
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Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University |
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Collection: Biology and Medicine |
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| 52 | BRADSHAW 978-0-12-374145-5 00388 Multi-Pass Receptors | ||
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Summary: - neered human A2A adenosine receptor in complex with the subtype specific antagonist ZM241385 provides... a number of additional surprises. The ligand binds to the A2A ade- nosine receptor in an extended... ] Expressed engineered human ... |
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Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University |
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Collection: Biology and Medicine |
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| 53 | Draft: 3/12/2009 142:225 Growth Factor Receptor Signaling | ||
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Summary: B/HER-dependent transformation o ErbB/HER receptor-targeted cancer therapeutic agents o Molecular basis of response... /resistance to ErbB/HER-targeted therapies 2. Cytokine and hormone receptors; transcription-dependent signaling (F... Draft: 3/12/2009 142:225 Growth Factor Receptor Signaling Outline: 1. ... |
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Source: Iowa Center for Gene Therapy |
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Collection: Biotechnology ; Biology and Medicine |
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| 54 | Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors | ||
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Summary: that the presynaptic properties of receptors modulating transmitter release are also de- termined by the target cell... implicating mGlu receptors as targets for neuro- protection (Bond et al., 1998). Perhaps the most well... was prevented by inhibitors of fatty acid formation and phospholipase ... |
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Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 55 | Characterization of Interactions between Death Receptor 5 and its Ligand TRAIL | ||
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Summary: mechanism of selective targeting of tumour cells by TRAIL. The third decoy receptor is the soluble member... of TRAIL to its target receptors leads to increased expression of TRAIL, thus causing auto... 103 Chapter 5 Characterization of Interactions between Death Receptor 5 and its Ligand ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 56 | 1999 Macmillan Magazines Ltd 7. Carter, C. S. et al. Anterior cingulate cortex, error detection, and the on-line monitoring of | ||
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Summary: genes, or in vivo site-directed mutagenesis of the a2A-receptor gene by gene targeting in mice7±11 . We... . Lakhlani, P. P. et al. Substitution of a mutant a2A-adrenergic receptor via ``hit and run'' gene targeting... ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 57 | International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors | ||
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Summary: International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 283 I. Brief historical background of nucleotides and their receptors... . . . . . . . . . ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 58 | ORIGINAL ARTICLE Cells in Behaviourally Relevant Brain Regions Coexpress Nuclear Receptor | ||
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Summary: coactivators (32). The p160 family also includes SRC-2 (also known as NCoA-2, TIF-2, GRIP-1; 33, 34), and SRC-3... , Zhou N, Scully R, Livingston DM. The nuclear hormone receptor coactivator SRC-1 is a specific target... ORIGINAL ARTICLE Cells in Behaviourally Relevant Brain Regions Coexpress Nuclear ... |
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Source: Tetel, Marc J. - Department of Biological Sciences, Wellesley College |
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Collection: Biology and Medicine |
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| 59 | PC PE PS PI SPM GangChol | ||
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Summary: segment of the extracellular domain of the EGF receptor is involved in targeting the EGF receptor to lipid... signaling, including the EGF receptor, has led to the consensus that these lipid domains play an important... of the EGF receptor and the role of lipid rafts in modulating ... |
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Source: Pike, Linda J. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 60 | Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational | ||
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Summary: are already targeted by known drugs, such as tamoxifen, a partial antagonist of estrogen receptor (ER... active ligands were included in the database. Most ligands targeted one of the library receptors... energy and numerical errors. It is calculated as follows: Ebind ¼ DEIntFF þ TDSTor þ a1DEHBond þ ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 61 | PERSPECTIVE Orphan nuclear receptors--new ligands | ||
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Summary: steroid receptors. Prominently inducible members of the rodent P450 3A gene family (CYP3A1, CYP3A2, CYP3A... , strategies were devised to identify orphan ligands using the receptor as a screening target. This process... to and activate tran- scription through a multimerized ... |
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Source: Blumberg, Bruce - Department of Developmental and Cell Biology, University of California, Irvine |
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Collection: Biology and Medicine |
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| 62 | 2011;71:6940-6947. Published OnlineFirst September 22, 2011.Cancer Res Qianzi Tang, Yiwen Chen, Clifford Meyer, et al. | ||
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Summary: predictions of the nuclear receptor target genes by integrating cistrome and transcriptome data and validated... profiles. Previous efforts to identify nuclear receptor target genes have mostly relied on differential... to secondary or tertiary effects of nuclear receptor activity. With ... |
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Source: Liu, Xiaole Shirley - Dana-Farber Cancer Institute & Department of Biostatistics, Harvard University |
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Collection: Computer Technologies and Information Sciences ; Biotechnology ; Biology and Medicine |
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| 63 | 5-HT Receptors and the Neuromodulatory Control of | ||
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Summary: A/7 receptors, there was no evidence to support tonic activation of the 5-HT2A/2C receptor, since... the low expression of 5-HT2A/2C receptors in the dorsal horn (see Section 2.2.2). 3.2 5-HT1A/1B RECEPTORS... are located on ... |
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Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 64 | Glycosylation of b1-adrenergic receptors regulates receptor surface expression and dimerizationq | ||
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Summary: the b2-adrenergic receptor [15], a2A-adrenergic re- ceptor [30], and dopamine D1 receptor [31]. Con... - adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of a2... .S. Barsh, D. Bernstein, B.K. ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 65 | Bulletin of Mathematical Biology (2008) 70: 15251569 DOI 10.1007/s11538-008-9321-6 | ||
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Summary: of the system was defined as A(t) = a1R(t) + a2X(t) + a3Y(t) + a4D(t), (1) #12;1534 Tindall et al. Fig. 6... , the intracellular phosphorylation cascade, membrane receptor clus- tering, and spatial modeling of intracellular... gradient along their own length, bacteria use a system of membrane receptors and ... |
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Source: Maini, Philip K. - Centre for Mathematical Biology & Mathematical Institute, University of Oxford |
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Collection: Mathematics ; Biology and Medicine |
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| 66 | For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133 | ||
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Summary: (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... and vasorelaxant A2 receptors are also expressed on vas- cular smooth muscle.1,21 Some vascu- LOOKING AHEAD All... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 67 | Pharmacological characterization of serotonin receptor subtypes modulating primary aerent input to deep dorsal horn neurons in | ||
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Summary: used were; NAN-190 or WAY-100635, 5-HT1A receptor antagonists; ketanserin, a 5-HT2A/2C receptor... , application of the 5-HT2A/2C receptor antagonist ketanserin alone did not modify synaptic responses... be explained in relation to the relatively ... |
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Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 68 | Cys-loop receptors: new twists and turns | ||
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Summary: -277 of the g-aminobutyric acid type A receptor a2 subunit define agonist efficacy and potency. J. Biol... the general processes that target the muscle receptor to a nervemuscle synapse, but almost nothing is known... Cys-loop receptors: new twists and turns Henry A. ... |
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Source: Lester, Henry - Division of Biology, California Institute of Technology |
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Collection: Biology and Medicine |
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| 69 | Neuregulin1 Downregulates Postsynaptic GABAA Receptors at the Hippocampal Inhibitory Synapse | ||
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Summary: protein kinase II (CaMKII), GAD, and NR2A/2B/2C were 23, 24, 24, 21, 26, 28, and 24, respectively. The PCR... of GABAA 1/ 2, 2, 2 subunits, NR2A/2B/2C subunits, and GAD65/67 was described previously (Sakaguchi et al... Neuregulin1 Downregulates Postsynaptic GABAA Receptors at the ... |
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Source: Corfas, Gabriel - F.M. Kirby Neurobiology Center, Children's Hospital Harvard Medical School |
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Collection: Biology and Medicine |
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| 70 | Modulation of triheteromeric NMDA receptors by N-terminal domain ligands | ||
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Summary: . Similarly, NR1/2A/2C receptors are inhibited by zinc with high potency but low efficacy. Therefore... triheteromeric NR1/2A/2AH128SN614K receptors. When 200 nM Zn was applied under these conditions, 15.7 ± 1... AH128SN614KT690I cDNA, a pure triheteromeric ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 71 | Introduction In 1987, a receptor was identified in a search for tyrosine | ||
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Summary: the RasMAP-kinase pathway (Kim et al., 2002). Likewise, EphA2 downregulates the RasMAP-kinase pathway... carcinoma cells, ligand activation of EphA2 causes dissociation of FAK and the transient recruitment... be cell-type specific because EphA2 activity can ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 72 | This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research | ||
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Summary: as GRIP1, TIF2 and NCoA-2) [216,71] and SRC-3 (AIB1, TRAM-1, p/CIP, ACTR and RAC3) [6,194]. The SRC family... transcription of target genes, SRC-1 must be recruited to the receptor dimer complex first, followed by CBP [104... 's personal copy Review Who's in charge? Nuclear receptor ... |
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Source: Tetel, Marc J. - Department of Biological Sciences, Wellesley College |
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Collection: Biology and Medicine |
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| 73 | REVIEW ARTICLE Nuclear Receptor Coactivators: Essential Players for Steroid Hormone | ||
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Summary: and enhancers of target genes (33). Coactivators of steroid receptors The p160 family Steroid receptor... as GRIP1, TIF2 and NCoA-2) (44, 45) and SRC-3 (AIB1, TRAM-1, p / CIP, ACTR, RAC3) (46, 47). The SRC family... coactivator-3 is required for progesterone receptor ... |
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Source: Tetel, Marc J. - Department of Biological Sciences, Wellesley College |
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Collection: Biology and Medicine |
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| 74 | Recombinant Production and Properties of Binding of the Full Set of Mouse Secreted Phospholipases A2 to the Mouse M-Type Receptor | ||
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Summary: -type receptor is discussed on the basis of our current knowledge of sPLA2 functions. Secreted phospholipases A2... 2 to the Mouse M-Type Receptor Morgane Rouault,,§ Catherine Le Calvez,,§ Eric Boilard,,§ Fanny... ReceiVed NoVember 29, 2006 ABSTRACT: To date, 12 secreted phospholipases ... |
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Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 75 | Oligomeric forms of G protein-coupled receptors (GPCRs) | ||
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Summary: found in crystals of engineered human b2-adrenergic receptor [29] and an engineered human A2A adenosine... 1265 30 Jaakola, V.P. et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor... GPCRs because the area occupied by a single GPCR on ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 76 | Kainate receptors coming of age: milestones of two decades of research | ||
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Summary: as conventional ionotropic receptors. These modulatory roles position KARs as potentially fa- vorable targets... -dated the cloning of its target receptors by well over a decade. KA is a powerful neurotoxin that elicits a complex... subunit GluA2 [27], and which most ... |
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Source: Contractor, Anis - Department of Physiology, Northwestern University |
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Collection: Biology and Medicine |
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| 77 | Behaioural Pharmacology 2001; 00:1 10 REVIEW Serotonin receptors in mood disorders: a combined1A | ||
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Summary: receptors. These may include 5-HT , 5-HT and 5-HT receptors, since2A 2C 3 selective antagonists acting... , 5-HT , 5-HT , etc. . Serotonergic neurons2A 2C 3 have a slow and spontaneous rhythmic activity of 4... Beha¨ioural Pharmacology 2001; 00:1 10 REVIEW Serotonin ... |
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Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh |
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Collection: Biology and Medicine |
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| 78 | Role of delivery and trafficking of d-opioid peptide receptors in opioid | ||
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Summary: less adverse effects than do m-opioids [7,8], the DOP receptor is proposed to be a potential target... Role of delivery and trafficking of d-opioid peptide receptors in opioid analgesia and tolerance Xu... for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Changes in the number of ... |
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Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences |
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Collection: Biology and Medicine |
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| 79 | International Union of Pharmacology. XXXV. The Glucagon Receptor Family | ||
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Summary: . . . 177 G. The glucagon-like peptide-1 receptor as a therapeutic target... , oxyntomodulin, or miniglu- cagon in mice with targeted disruption of the re- GLUCAGON RECEPTOR FAMILY 175 #12... International Union of Pharmacology. XXXV. The Glucagon Receptor Family KELLY E. MAYO, LAURENCE J |
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Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University |
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Collection: Biology and Medicine |
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| 80 | Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India | ||
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Summary: the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... receptors might be target analgesics for the treatment of ureteral colicky pain and that an additional... molecule. Receptors for ATP have been cloned and ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 81 | PERSPECTIVE New Determinants of Receptor-Effector Coupling: Trafficking | ||
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Summary: , cytosolic phospho- lipase A2; MAP kinase, mitogen-activated protein kinase; AC, adenylyl cyclase; PLC... Gq/11) and cytosolic phospholipase A2 (cPLA2) (Farmer and Burch, 1992). The increases... phospholipase A2 in regulating arachi- donic acid release in ... |
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Source: Ostrom, Rennolds - Department of Pharmacology, University of Tennessee Health Science Center |
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Collection: Biology and Medicine |
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| 82 | *National Institute of Child Health and Human | ||
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Summary: - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... and locomotor depressant effects85 . The most well-known signal transduction mecha- nism for A2A receptors... is the ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 83 | SPECIAL ISSUE Glycine receptors: recent insights into their | ||
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Summary: potent on a1 than a2 receptors and can be used to distinguish between these isoforms. Tropise- tron... and colchicines are more potent blockers at a2 than a1 receptors. The organic anion cyanotriphenylborate acts... a stoichiometry of 3a : ... |
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Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 84 | Eph receptor tyrosine kinases and ephrins have been identified in organisms ranging from sponges to flies and worms to chick, | ||
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Summary: , but also to several other targets in the forebrain [42·,54]. The conserved module of graded ephrin-A2/A5... mm z xm m m EphA2 d EphR EphA8 EphA4 EphA6 EphA3 EphA7 EphA5 EphB2 EphB1 EphB3 EphB4 EphA1 m c c eph... ephrin-A5 ephrin-A6 ephrin-A4 ephrin-B3 ephrin-B1 ephrin-B2 ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 85 | REVIEW ARTICLE The journey to establish purinergic signalling in the gut | ||
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Summary: cloned, namely, A1, A2A, A2B, and A3. Seven subtypes of P2X receptors have been identified... and P2Y12 receptors were demonstrated on enteric neurons. Differential gene expression of A1, A2A, ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 86 | Muscarinic Receptor Subtypes in the Lateral Geniculate Nucleus: A Light and | ||
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Summary: of a cytoplasmic laminated body associated with heavy deposits of m3 label. Scale bars 3 µm in A, 2 µm in B... Muscarinic Receptor Subtypes in the Lateral Geniculate Nucleus: A Light and Electron Microscopic... the brainstem. The purpose of this study was to identify and localize specific muscarinic ... |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 87 | Original Paper Cells Tissues Organs 2002;172:255264 | ||
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Summary: . 1a, 2), and in endothelial cells of thymic blood vessels (fig. 3, 4). In T cells, P2Y2 receptor m... RNA was primarily localised in the cytoplasm (fig. 1a, 2a, b). The cytoplasmic expression of transcripts also... Identification of P2Y2 Receptor mRNA in the Rat ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 88 | Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson | ||
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Summary: as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... receptors lead to suppression of pain signaling, while A2A receptors lead to pain ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 89 | Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor [Journal Home Page] [Search the Journals] [Table of Contents] [PDF version of this article] [Download | ||
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Summary: Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor... Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor the binding of different... Phospholipase ... |
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|
Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle |
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Collection: Chemistry ; Biology and Medicine |
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| 90 | G protein-coupled receptor drug discovery: Implications from the crystal structure of rhodopsin | ||
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Summary: .56 and often A2.57, are present in TM2. The most conserved motif in TM3 is an Arg residue, R3... of the target receptor. Some companies are able to significantly enhance their hit rate in screening compound... G protein-coupled receptor drug discovery: Implications from the crystal ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 91 | NPY signaling through Y1 receptors modulates thalamic oscillations | ||
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Summary: of the three Y receptor agonists. Fig. 2A2, B2 and C2 shows representative sweeps within these recordings... ). Effects of the Y1 receptor agonist Leu31Pro34NPY (A1 and A2), the Y2 receptor agonist PYY336 (B1 and B2... capsule ... |
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Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University |
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Collection: Biology and Medicine |
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| 92 | ASSOCIATE EDITOR: DIANNE M. PEREZ The Significance of G Protein-Coupled Receptor | ||
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Summary: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 925 4. A2a-adenosine receptor structure... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 907 1. Expansion of G protein-coupled receptor drug targets into class B, ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 93 | NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of | ||
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Summary: and dendritic compartments (3, 9). Selectively GABAB(1a,2) receptors control the release of glutamate, whereas... receptors (25). Antagonizing GABAB receptor activity with CGP54626A (2 M for 10 min) did not attenuate NMDA... b,2) but not ... |
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Source: Oertner, Thomas - Friedrich Miescher Institute, Switzerland |
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Collection: Biology and Medicine |
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| 94 | Purinergic signalling *Geoffrey Burnstock | ||
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Summary: /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... . Adenosine, via A2A receptors, has a protective effect in a rat model of Parkinson's disease, perhaps... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 95 | Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian-Specific | ||
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Summary: copy. Three of these pairs (pufferfish a2, b4 and r1) are composed of very similar genes that have... -A receptor gene family: new targets for therapeutic intervention. Neurochem Int 34: 387390. 12. Rabow LE... Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on ... |
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Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa |
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Collection: Biology and Medicine |
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| 96 | q 2001 International Society for Neurochemistry, Journal of Neurochemistry, 76, 18871894 1887 Journal of Neurochemistry, 2001, 76, 18871894 | ||
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Summary: construct for the third intracellular loop of human a2A- adrenergic receptor (a2-AR-I3L) was generously... and a2-adrenergic receptors. J. Biol. Chem. 272, 17836±17842. Zhang J., Ferguson S. S., Barak L. S... of ... |
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|
Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences |
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Collection: Biology and Medicine |
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| 97 | P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock | ||
|
Summary: phase hyperaemia mediated via A2A receptors on smooth muscle cells. Red blood cells as regulators... regulation were found in PubMed. Among the 15 receptor subtypes, one is the target for one of the most widely... of the other 15 receptors are promising drug ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 98 | Orphan nuclear receptors adopted by crystallography Holly A Ingraham1 | ||
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Summary: and NR5A2). Both receptors are crucial for normal embryonic development [1822], and in the adult steroid... 4A2) LBDs are almost identical, with features unique to only this subfamily. The first... HNF4a 2.8 A° None 626 A° 3 Fatty acid [46] ... |
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Source: Ingraham, Holly - Department of Physiology, University of California at San Francisco |
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Collection: Biology and Medicine |
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| 99 | J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW | ||
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Summary: in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... -dependentcytosolic phospholipase A2 activity in primary sensory neurons is claimed to be a key event in neuropathic pain (Tsuda ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 100 | Annu. Rev. Physiol. 2006. 68:491505 doi: 10.1146/annurev.physiol.68.040104.131050 | ||
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Summary: receptor (52) Lysophosphatidic acid receptor A2 (53) Luteinizing hormone receptor (54) RAMP3... . TABLE 1 Hormone receptor targets of NHERF G proteincoupled receptors 2-adrenergic receptor (15, 21... ... |
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|
Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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