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Sample search results for: aav5 vector delivery

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1 JOURNAL OF VIROLOGY, Apr. 2004, p. 33613371 Vol. 78, No. 7 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.7.33613371.2004
 

Summary:  serotype 5 (AAV5) requires sialic acid on host cells to bind and infect. Other parvoviruses, including... . In contrast to AAV5, AAV2 does not bind sialic acid, but rather binds heparan sulfate proteo- glycans at its... to cell receptor attachment, we determined the structure of ...

  

Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
2 JOURNAL OF VIROLOGY, Aug. 2002, p. 76517660 Vol. 76, No. 15 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.15.76517660.2002
 

Summary:  and ITR of AAV5 fail to cross-complement those of AAV1 to -4 (6). Vectors constructed from AAV2, AAV3, AAV... variation among the AAV serotypes (7, 30). Unlike AAV2, AAV 2/6 and AAV5 vectors are not inhibited by hep... ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
3 Current Gene Therapy, 2003, 3, 281-304 281 1566-5232/03 $41.00+.00 2003 Bentham Science Publishers Ltd.
 

Summary:  the development of AAV vector production strategies involving Rep or ITR elements from AAV-5. Within the AAV-2... of AAV- 5-based vectors. Results from vector production indeed indicate that particle titers from helper... of AAV-2 ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
4 original article 594 www.moleculartherapy.org vol. 18 no. 3, 594600 mar. 2010
 

Summary:  -CB-FL and rAAV5-CB-RL vec- tors (the same vectors used for the chimp studies). Figure 2c shows... AAV1 and rAAV5 vectors in the chimpanzee airway in vivo As in vitro polarized airway epithelia cannot... of luciferase activity from each vector was ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
5 original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285
 

Summary:  label. Both rAAV5 and rAAV1 vectors were capable of transducing a subset of long-lived Clara cells... results demonstrate that the rAAV1 and rAAV5 vectors are indeed able to transduce epi- thelial slow... expression in rAAV1Cre, rAAV2Cre, or ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
6 This is an Accepted Article that has been peer-reviewed and approved for publication in the Journal of Neurochemistry, but has yet to undergo copy-editing and proof correction. Please
 

Summary:  in vivo DOPA production and studies of ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats Tomas... and metabolism. For this purpose, we injected a fixed amount of rAAV5-TH vector and increasing amounts of rAAV5... ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
7 Intrastriatal rAAV-Mediated Delivery of Anti-huntingtin shRNAs Induces Partial Reversal of Disease Progression
 

Summary:  strategy was based on the use of recombinant adeno-associated virus serotype-5 (rAAV5) vectors to deliver... demonstrated that rAAV5 vectors can efficiently mediate the widespread and long-term expres- sion of transgenes... ]. Using a similar strategy, we examined ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
8 HUMAN GENE THERAPY 19:7181 (January 2008) Mary Ann Liebert, Inc.
 

Summary:  of the spinal cord (Kuchler et al., 2002). MATERIALS AND METHODS rAAV vector production rAAV5 virus production... axonal projections in spinal gray matter in specimens obtained from animals with RN delivery of rAAV5-GFP... ). Cortex injections ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
9 Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo
 

Summary:  or general delivery of AAV vectors. Previously, we had determined that rAAV5-siHUNT-2, but not rAAV5-siHUNT-1... of rAAV5-HD6 and HD7 We generated rAAV serotype 5 (rAAV5) viral ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
10 JOURNAL OF VIROLOGY, Jan. 2005, p. 364379 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.364379.2005
 

Summary:  and AAV-5 to generate a novel hybrid ITR vector genome. This hybrid ITR viral vector contained one AAV-2... ITR and one AAV-5 ITR at opposite ends of the viral genome. Hybrid ITR vectors functionally transduced... a single encoded transgene at an ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
11 JOURNAL OF VIROLOGY, Mar. 2002, p. 20432053 Vol. 76, No. 5 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.5.20432053.2002
 

Summary:  for development as a gene delivery vector (2, 5). Although less is known about AAV-5 molecular biology... - fer vector for a longer time than AAV-5, there is a greater understanding of the mechanisms for viral... be used as the helper for ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
12 Sites in the AAV5 capsid tolerant to deletions and tandem duplications Kaoru Hida a
 

Summary:  ]. For example, AAV5 may be the vector of choice for gene ther- apy targeted for the lungs; it transduces... containing the AAV2 rep and Topo-AAV5 with wt or library cap, respectively, and a vector plasmid containing... Sites in the ...

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
13 Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia*
 

Summary:  reported that gene delivery to mouse lung using rAAV1, rAAV5, and rAAV6 is significantly higher than with r... , treatment with proteasome inhibitors more significantly enhanced transduc- tion with rAAV2 and rAAV5 vectors... and ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
14 Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant
 

Summary:  infection with rAAV5 vectors were significantly different between mouse and human ALI airway epithelia. Our... in polarized human airway epithelia demonstrate that both rAAV2 and rAAV5 vectors have similar levels of apical... in intracellular trafficking between ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
15 Directed evolution of adeno-associated virus to an infectious respiratory virus
 

Summary:  delivery efficiency of AAV2. Furthermore, more recently used serotypes, such as AAV5 and AAV9, possess only... distinct receptors, AAV2 (heparan sulfate) and AAV5 (sialic acid) (13­16). Subsequent selection... combined 2 divergent serotypes that use distinct receptors, AAV2 and ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
16 Neurobiology of Disease Positron Emission Tomography Imaging Demonstrates
 

Summary:  consequences of the continuous DOPA delivery by the rAAV5­TH and rAAV5­GCH1 vectors were assessed... - binant adeno-associated viral (rAAV5) vectors. Local striatal DOPA synthesis provided in this way ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
17 JOURNAL OF VIROLOGY, July 2003, p. 73617366 Vol. 77, No. 13 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.13.73617366.2003
 

Summary:  of new AAV serotype vectors have demon- strated that both rAAV-5 and rAAV-6 are capable of effi- ciently... 2/5 nomenclature were pseudotyped with AAV-5 capsid as previously described (13). Luciferase vectors... -Strand Genome Conversion of Adeno-Associated Virus Type ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
18 JOURNAL OF VIROLOGY, Apr. 2005, p. 50475058 Vol. 79, No. 8 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.8.50475058.2005
 

Summary:  resolution structures of AAV2 and AAV5 (40, 63), as well as those of the autonomous parvoviruses Aleutian... experiments with AAV5 have demonstrated improved binding and transduction * Corresponding author. Mailing... affinity is weaker (49). However, AAV3 also lacks R585 and R588. Transduction by AAV4 and ...

  

Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
19 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.16.76627671.2001
 

Summary:  as a gene therapy vector. Detailed sequence comparisons indicate that the AAV-5 capsid proteins are sig... that recombinant AAV-5 vectors might have a unique niche in gene therapy applications. For example, AAV-5 likely... ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
20 HUMAN GENE THERAPY 15:405413 (April 2004) Mary Ann Liebert, Inc.
 

Summary:  vector genome (containing the ITRs/LacZ ex- pression cassette) into AAV5 or AAV8 capsids by cotransfec... of Adenoviral and Adeno-Associated Viral Vectors for Pancreatic Gene Delivery In Vivo ALFRED Y. WANG,1,2 PETER D... vectors have been developed for organ systems ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine


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21 JOURNAL OF VIROLOGY, Jan. 2006, p. 426439 Vol. 80, No. 1 0022-538X/06/$08.00 0 doi:10.1128/JVI.80.1.426439.2006
 

Summary:  , which hampered analyses of the contribution of AAV-5 ITRs to vector function in the past and represented... be exploited by flanking vector DNAs with AAV-5 ITRs, as was previously suggested (17, 52). A second example... (10 l; see above). Cloning of AAV genotype ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
22 Adeno-associated viral vectors and stereotaxic
 

Summary:  Adeno-associated viral vectors and stereotaxic delivery Eric Washburn Vollum Viral Core washbure... , AAV5, AAV8, AAV9, AAVDJ Photoreceptor Cells AAV5 Lung AAV9 Heart AAV8 Pancreas AAV8 Kidneys AAV2... types · ~4.7 kb wild type genome #12;AAV Life Cycle #12;Packaging ...

  

Source: Chapman, Michael S. - Department of Biochemistry and Molecular Biology, Oregon Health and Science University

 

Collection: Biology and Medicine

 
23 JOURNAL OF VIROLOGY, Mar. 2004, p. 28632874 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.28632874.2004
 

Summary:  . Recently, it has been reported that rAAV-5 vectors more effectively transduce murine lungs. Intranasal... delivery of pseudotyped AAV-2 genomes with AAV-5 capsids (rAAV- 2/5) results in a 250-fold-higher level... accepted that in vivo delivery ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
24 original article 2096 www.moleculartherapy.org vol. 17 no. 12, 20962102 dec. 2009
 

Summary:  has been achieved by an intravitreally injected AAV vector. Interestingly, AAV5 is apparently the only... - tion in conjunction with AAV5 delivery may allow for targeting of outer retinal cells without the need... cell types from the vitreous, with ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
25 11/13/11 10:33 AMAbstract Print View Page 1 of 2http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...472c-8713-73eddce872b7&cKey=e99c3f48-6778-47ba-9f60-c17304239095
 

Summary:  -neuronal human promoters (hThy1, hSyn) and using AAV5 as the delivery vector, motivated by the translational... ., 2009; Lee et al., 2010). Here we report functionality of AAV5-CaMKII-C1V1 in macaque cortex. Light... advantages of AAV vectors ...

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
26 2011NatureAmerica,Inc.Allrightsreserved. nature neurOSCIenCe advance online publication
 

Summary:  cortex. All AAV5 vectors had a titer of 1012 particles per ml. We also injected one site in monkey B... a lentiviral vector instead of AAV5 (or a low virus titer instead of a high virus titer), or by enhancing... pseudotyped with serotype 5 (here referred to as ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
27 NATURE NEUROSCIENCE VOLUME 14 | NUMBER 3 | MARCH 2011 387 T E C H N I CA L R E P O R T S
 

Summary:  in somatosensory cortex. All AAV5 vectors had a titer of 1012 particles per ml. We also injected one site in monkey... strong promoter (like hThy-1), by using a lentiviral vector instead of AAV5 (or a low virus titer instead... pseudotyped with serotype 5 (here ...

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
28 Enhanced Preparation of Adeno-Associated Viral Vectors by Using High Hydrostatic Pressure to
 

Summary:  and Goudsmit, 2001). In addition, AAV5 vectors are capable of enhanced gene delivery to tissues in which AAV2... ). Briefly, AAV2-GFP vector backbone, pHelper, and pXR5 (which expresses AAV5 Cap and an ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
29 HUMAN GENE THERAPY 16:781791 (July 2005) Mary Ann Liebert, Inc.
 

Summary:  hippocampal transductions of rAAV1 (A), rAAV2 (B), and rAAV5 (C) (1 1013 to 8 1013 vector genome copies... transduction with rAAV5-pseudo- typed vectors (Peden et al., 2004). Furthermore, intrastriatal rAAV2 injections... and ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
30 Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display
 

Summary:  transfer applications. RESULTS Phenotype of Transduced Cells rAAV1 and rAAV5 vectors have been reported... , including AAV1 and AAV5 [42,43]. In this study, we quantitatively evaluated three distinct rAAV vectors, r... cassette under the control of the synthetic CBA ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
31 Helper Virus-Free, Optically Controllable, and Two-Plasmid-Based Production of Adeno-associated
 

Summary:  -intensive preparation of an additional plasmid [e.g., 16]. In one study, AAV-2 vector pseudotyping with AAV-5 METHODdoi... , the only excep- tion being the AAV-5-based vector. This was, however, not surprising regarding the known... highest titers among all pRC ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
32 Intracellular trafficking of adeno-associated viral and JF Engelhardt1,2,3
 

Summary:  -linked sialic acid45 Unknown AAV5 N-linked sialic acid45,46 PDGFR54 Intracellular trafficking of AAV vectors W... for AAV4 and AAV5. AAV5 primarily uses N-linked sialic acid for binding, whereas AAV4 preferentially uses... factor receptor (PDGFR) ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
33 HUMAN GENE THERAPY 18:8187 (January 2007) Mary Ann Liebert, Inc.
 

Summary:  ). In comparison with homologous AAV2 or AAV5 ITR vectors, hybrid 2:5-ITR vec- tors have been shown to less... AAV5 and AAV2 ITRs, and these two vector genotypes TRANS-SPLICING HYBRID-ITR AAV VECTORS 83 FIG. 2... homologous-ITR ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
34 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  ­27 Specifically, AAV1 and AAV5 sero- types have more favorable properties for reproducible production at high... /5, and AAV2/8 in the basal ganglia of nonhuman primates. We now pres- ent data showing that AAV1 and AAV5... for the dif- ferent serotypes. AAV 1 AAV 5 ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
35 JOURNAL OF VIROLOGY, Oct. 2006, p. 98319836 Vol. 80, No. 19 0022-538X/06/$08.00 0 doi:10.1128/JVI.00878-06
 

Summary:  therapy vector. MATERIALS AND METHODS Plasmids. The AAV2, AAV5, AAV6, and AAV8 bait plasmids were con... factor receptor (PDGFR) (7, 15, 34). Like AAV5, AAV4 was also shown to interact with sialic acid; however... [AAV5], 442 to 1863 [AAV6], and ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
36 JOURNAL OF VIROLOGY, June 2004, p. 63446359 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.63446359.2004
 

Summary:  vector after purification; right lane, rAAV5-GFP vector after purification. VOL. 78, 2004 PREIMMUNIZATION... as previously described (44). rAAV5-eGFP was a pseudotyped vector using the same transgene-containing plasmid... as the rAAV2 ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
37 GENE THERAPY Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors
 

Summary:  serotype vectors Initial vector AAV-1 AAV-2 AAV-3 AAV-4 AAV-5 AAV-6 AAV-1pv 1600 ND ND ND ND to 400 1600... the AAV-2 vector. Mingozzi et al20 reported up to 25-fold higher efficiency from AAV-5 in the murine liver... % of the maximum hFIX protein ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
38 HUMAN GENE THERAPY 16:11161123 (September 2005) Mary Ann Liebert, Inc.
 

Summary:  epithelia were infected from the apical mem- brane with rAAV2 or rAAV5 CFTR-PTM vectors in the presence... . Levels of CFTR correction seen with rAAV2 (1.07 0.24 A) and rAAV5 (0.90 0.20 A) CFTR-PTM vectors were... -CF epithelia, and was similar for both rAAV2 and ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
39 SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret,
 

Summary:  AAV serotypes closely mirrors that observed in human epithelia (rAAV14 rAAV2DrAAV5), while transduction of mouse... epithelia was significantly different (rAAV14rAAV5brAAV2). Similarly, ferret, pig and human epithelia also... and rAAV5 transduction of human and mouse ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
40 HUMAN GENE THERAPY 18:871880 (October 2007) Mary Ann Liebert, Inc.
 

Summary:  the vectors with the AAV-5 capsid, which transduces photoreceptors more efficiently than AAV-2 (Yang et al... , we used viral vector-mediated delivery to express shRNAs in retinal cells in vivo, to take advantage... OPS promoter does not support reporter expression in RPE (Flannery et al., ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine


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41 A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2
 

Summary:  . Firstly, when the assay was conducted with AAV5(gfp), we only observed a decrease in vector transduction... cathepsin B or L, whereas no significant change was seen with the AAV5 vector (Figure 4b), confirming... 40 30 20 10 0 0 20 M 40 M Ca074-Me AAV2 AAV2AAV8 ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
42 Expert Review Designer Gene Delivery Vectors: Molecular Engineering and Evolution
 

Summary:  , respectively (143,144). Likewise, Peden et al. have shown that AAV5 vector can transduce rat brain pre... , and AAV5 vectors to mouse skeletal muscle. Prior immunization with various serotypes did not significantly... Expert Review Designer Gene ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
43 original article 2088 www.moleculartherapy.org vol. 17 no. 12, 20882095 dec. 2009
 

Summary:  variable efficiencies (AAV5).7,18 Additionally, recent work in the retina utilizing AAV vectors... to develop more efficient gene delivery vectors for glia have met with limited success. Recently, viral... reported for AAV4 and AAV5,7,8,18,22 ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
44 original article The American Society of Gene Therapy Molecular Therapy vol. 16 no. 10, 17031709 oct. 2008 1703
 

Summary:  translate into novel gene-delivery properties distinct from the parent serotypes. AAV5 AAV8 AAV9 AAV4 2 4 5... ­1709 oct. 2008 1703 Adeno-associated virus (AAV) vectors are extremely effective gene-delivery vehicles... mutagen- esis and selection, that successfully generated AAV2 ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
45 Dual Therapeutic Utility of Proteasome Modulating Agents for Pharmaco-Gene Therapy of the
 

Summary:  for the AAV2 vectors groups (Fig. 3B). Enhancement of vector-derived mRNA/ DNA ratios for the AAV5 vector... , rAAV2 vectors performed better than rAAV5 vectors. These findings support the notion that ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
46 Brain Tissue Depth (mm) LightPowerDensity(mW/mm2
 

Summary:  and packaging The recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged by the viral... A. Control of BLA glutamatergic projection neurons was achieved using an adeno-associated virus (AAV5) vector... ITC cells BLA CeA ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
47 Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Gene therapy for hemophilia
 

Summary:  that from an AAV2 vector in dogs with hemophilia B, while expres- sion from AAV5 was lower than that from... AAV2. Sim- ilarly, AAV5 or AAV8 vectors expressing human FIX were not more effective than AAV2 vectors... :875­888. This paper ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
48 HUMAN GENE THERAPY 18:344354 (April 2007) Mary Ann Liebert, Inc.
 

Summary:  of AAV5 and AAV6 showed that whereas both vectors had high transduction rates in well... that is exposed to the virus. Sialic acid is required for AAV5 gene transfer (Wal- ters et al., 2001... ) and is an abundant sugar on the apical sur- face, consistent with the better performance of ...

  

Source: Miller, Dusty - Division of Human Biology, Fred Hutchinson Cancer Research Center

 

Collection: Biology and Medicine

 
49 Adv Biochem Engin/Biotechnol (2005) 99: 1x DOI 10.1007/10_006
 

Summary:  distinct gene delivery properties. For example, in the brain AAV2 se- lectively transduces neurons, AAV5... AAV2 transduces phororeceptors, AAV5 capsid directs gene delivery to both retinal pigment epithelium... · Targeting · Viral vector #12;2 ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
50 Global and local fMRI signals driven by neurons defined optogenetically by type and wiring
 

Summary:  with the adeno-associated viral vector AAV5-CaMKIIa::ChR2(H134R)-EYFP todrive expressionofachannelrhodopsin(ChR2... observed with AAV5-CaMKIIa::ChR2- EYFP but not with saline injection (P , 0.001; asterisk, optical... Figure 2 | Nonlocal mapping of the causal role of cells defined by ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
51 Molecular Engineering of Viral Gene Delivery Vehicles
 

Summary:  with novel gene delivery capabilities. Rational design of viral vectors has yielded successful advances... and viral delivery vehicles. Whereas synthetic vectors, usually a polymer-DNA or lipid-DNA complex, offer... ) vectors for gene delivery (1). However, both basic ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
52 Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders
 

Summary:  by lentiviral vectors in the brain has been shown to decrease Ah load in AD mice [90]. rAAV5 encoding neprilysin... AAV as yet but has been tried with various other vectors [71]. However, in one study, rAAV-mediated delivery... I). Another study using ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
53 original article 2114 www.moleculartherapy.org vol.15no.12,21142123dec.2007
 

Summary:  of bioelectric properties and susceptibil- ity to rAAV infection with rAAV1, rAAV2, and rAAV5 serotype vectors... ) Illustration of the proviral vector used to pseudo- type package into rAAV1, rAAV2, or rAAV5 capsids... with three rAAV sero- types (AAV1, AAV2, ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
54 Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd.
 

Summary:  trans-duction efficiency was achieved with rAAV4 and/or rAAV5 vectors in the ependymal cells... of the lateral ventricle compared to rAAV2 vectors. In addition, AAV5 was also able to transduce not only... ) Transduction of murine cerebellar neurons with recombinant ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
55 Current Gene Therapy, 2007, 7, 347-360 347 1566-5232/07 $50.00+.00 2007 Bentham Science Publishers Ltd.
 

Summary:  unpublished obser- vations). Finally, we have shown that acute re-administration of rAAV5 vectors, which... and promising tool for the treatment for neurological disorders. Viral vectors are ideal gene delivery vehicles... therapy must be thoroughly evaluated and characterized. ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
56 11/13/11 10:34 AMAbstract Print View Page 1 of 2http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...472c-8713-73eddce872b7&cKey=3ac40567-8b18-4983-84a3-c744f50c82da
 

Summary:  Abstract Program#/Poster#: 306.13/YY24 Presentation Title: Optogenetic projection targeting with AAV5... to label with unilateral injections of AAV5 in combination with the promoters hSyn and hThy-1 in premotor... traveling of AAV5 between cortex and thalamus. To ...

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
57 MOLECULAR THERAPY Vol. 5, No. 1, January 2002 Copyright The American Society of Gene Therapy
 

Summary:  FIV and AAV5 vectors. Neuroreport 11: 2669­2673. 27. Choi-Lundberg, D. L., et al. (1998). Behavioral... delivery to the central nervous system (CNS) has been facilitated by the development of new viral vectors... Targeted Retrograde Gene Delivery for Neuronal ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
58 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  ). All of the vectors contained AAV5 serotype capsids. These had been shown by us and others14... . MAterIAls And MetHods rAAV vectors. All vectors have been packaged in AAV5 capsid and puri- fied... as the PLD2 rAAV vector. ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
59 Systemic Mannitol-Induced Hyperosmolality Amplifies rAAV2-Mediated Striatal Transduction to a
 

Summary:  of mannitol 10 min after vector delivery enhanced transduction of adenovirus in the CNS. In contrast, we found... . Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA... antibodies inhibit rAAV2-, but not ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
60 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  si-312 si-312 AAV5 em pty R atsyn 100 80 60 40 20 0 b Figure 5 Quantitative estimation... terminal repeats and were packaged in AAV5 capsids that were purified as described previously.4,23 The GFP... in addition to the shRNA cassette driven by an H1 promoter. Empty ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine


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61 SUPPLEMENTARY INFORMATION 1www.nature.com/nature
 

Summary:  are available online at www.optogenetics.org. The recombinant AAV vectors were serotyped with AAV5 coat proteins... , efficacy and transduction region. a, AAV5-CaMKII::ChR2-EYFP: Costaining for the excitatory marker Ca... .1038/nature09108 SUPPLEMENTARY INFORMATION Supplementary Figure 5 ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
62 The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration
 

Summary:  expressing the AAV5 capsid gene. The final titers were 1.0 1013, 1.7 1013, and 0.9 1013 vector genome (vg... and in the ventral tegmental area (Fig. 1A). These data are in agreement with our findings that showed that rAAV5... with GFP (Fig. 3 A­C). We also note that the use of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
63 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  trials testing the safety of vector-delivery of genes to treat PD (Mandel and Burger, 2004) (http... of the properties of each viral vector with regard to CNS gene delivery is shown in Table 3. Another concern... in the viral vector for delivery into the target cell. More than 100 ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
64 BioMed Central Page 1 of 9
 

Summary:  : Transduction of murine cerebellar neurons with recombinant FIV and AAV5 vectors. Neurore- port 2000, 11... direct vector injection has been reported [8,14], gene delivery to spinal cord MNs by retrograde axonal... -pseudotyped HIV-1-based vector might be an important ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
65 JOURNAL OF VIROLOGY, June 2008, p. 58875911 Vol. 82, No. 12 0022-538X/08/$08.00 0 doi:10.1128/JVI.00254-08
 

Summary:  distinct serotypes, such as AAV-1 and AAV-2 (30) and pairwise combinations of AAV-1 through AAV-5 (62... different AAV serotypes were present in the lab (for AAV-2, AAV-4, and AAV-5) or kindly provided by James... AAV and AAV-5. The other seven cap genes were ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
66 Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
 

Summary:  Directed evolution of adeno-associated virus yields enhanced gene delivery vectors Narendra... safe and efficient gene delivery vehicles. However, numerous challenges in vector design remain... evolution to generate `designer' gene delivery vectors with specified, ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
67 Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
 

Summary:  AAV2 vectors packaged in AAV5 capsids) was purified by iodixanol step gradients and Sepharose Q column... neurons and glia in the primate midbrain Pseudotyped rAAV2/5 vectors (rAAV2 vectors packaged in an AAV5... proteins for attachment and ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
68 Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain
 

Summary:  AAV2 vectors packaged in AAV5 capsids) was purified by iodixanol step gradients and Sepharose Q column... neurons and glia in the primate midbrain Pseudotyped rAAV2/5 vectors (rAAV2 vectors packaged in an AAV5... proteins for attachment and ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
69 [23] Adeno-Associated Virus Vectors for Short Hairpin RNA Expression
 

Summary:  establish AAV as a most promising alternative to using adeno- or retro-/lentiviral vectors as shRNA delivery... ] adeno-associated virus vectors for shRNA expression 383 #12;using a recombinant virus as delivery system... ). The viral vectors recently engineered as shRNA ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
70 Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer Superior
 

Summary:  for cardiac gene delivery by systemic vector administration. Key Words: adeno-associated virus, serotype, gene... investigated for the biology of AAV and explored as a gene delivery vector. Although recombinant AAV serotype 2... an optimal vector dose for cardiac gene ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
71 11/13/11 10:33 AMAbstract Print View Page 1 of 2http://www.abstractsonline.com/Plan/AbstractPrintView.aspx?mID=2...472c-8713-73eddce872b7&cKey=33a870a7-f4d8-4e91-b1a5-44f8d02f1076
 

Summary:  inhibitory opsin eNpHR3.0, under control of the CaMKII promoter using the AAV5 vector system, in squirrel

  

Source: Shenoy, Krishna V. - Neurosciences Program & Department of Electrical Engineering, Stanford University

 

Collection: Engineering ; Biology and Medicine

 
72 BioMed Central Page 1 of 12
 

Summary:  Pseudotyped AAV vectors were generated by packaging AAV2-based recombinant genomes in AAV1, AAV2 or AAV5... for AAV1 and pLT- RC03 for AAV5) and the relevant pAAV2 vector plasmid. ssAAV vectors were produced... glycoprotein (VSVG) are efficient ...

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
73 Fax +41 61 306 12 34 E-Mail karger@karger.ch
 

Summary:  and AAV5 vec- tors. Neuroreport 2000;11:2669­2673. 5 Haskell RE, Hughes SM, Chiorini JA, Alisky JM... ;28:216­221 DOI: 10.1159/000091919 Cerebellar Neurons and Glial Cells Are Transducible by Lentiviral Vectors... . In vitro, primary cell cultures of rat cerebellar granule cells were infected with lentiviral ...

  

Source: Bongarzone, Ernesto R. - Department of Anatomy and Cell Biology, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
74 Dynamics of Retrieval Strategies for Remote Memories
 

Summary:  RI restriction sites. The recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged... as the experimental mice associated with laser light delivery. For BLA optogenetic inhibition, 1.5 ml of AAV5 Ca... delivery of the ...

  

Source: Contractor, Anis - Department of Physiology, Northwestern University; Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
75 MOLECULAR THERAPY Vol. 4, No. 4, October 2001 Copyright The American Society of Gene Therapy
 

Summary:  delivery through heterodimerization. RESULTS Construction of Trans-splicing and Overlapping AAV Vector Sets... the Efficiency of Dual Vector Gene Delivery Although the current achievable level of transgene expres- sion might... vector medi- ated gene delivery, we ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
76 RNA knockdown as a potential therapeutic strategy in Parkinson's disease
 

Summary:  to the cyto- plasm.18 Delivery with viral vectors has the advantages that hard-to-transfect primary cells can... to the midbrain, but to date, rAAV1 and rAAV5 appear to provide the widest area of transduction, while gene... ) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
77 JOURNAL OF VIROLOGY, Jan. 2005, p. 214224 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.214224.2005
 

Summary:  Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice Hiroyuki Nakai,1 * Sally Fuess,1 Theresa A... adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target... tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a small

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
78 Optogenetics in Neural Systems Ofer Yizhar,1 Lief E. Fenno,1 Thomas J. Davidson,1 Murtaza Mogri,1 and Karl Deisseroth1,2,3,4,*
 

Summary:  /5, referred to simply as AAV2 or AAV5 here). AAV2 differs from AAV5 in the degree of viral spread, in both... rodents (Paterna et al., 2004) and primates (Mar- kakis et al., 2010). A microliter-scale volume of AAV5... Elsevier Inc. Neuron Primer #12;Samulski, 1998; ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
79 HUMAN GENE THERAPY 18:367378 (April 2007) Mary Ann Liebert, Inc.
 

Summary:  -throughput library selec- tion approach can aid in the design of enhanced viral gene delivery vectors. 367 OVERVIEW... in genetic engineer- ing permit the customized design of AAV vectors for improved gene delivery, often based... not included, nor were purified vectors analyzed for ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
80 Current Gene Therapy, 2009, 9, 375-388 375 1566-5232/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  , we and others have shown that there is apparently little to no brain immune response to the AAV5... delivered via con- vection enhanced delivery where the vector is spread mainly by inducing artificial edema... some doubt in the field about trophic factor delivery for the treatment of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine


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81 LETTER doi:10.1038/nature10194 Excitatory transmission from the amygdala to
 

Summary:  -Camk2a­EYFP and AAV-Camk2a­NpHR3.0­EYFP were packaged as AAV5 by the University of North Carolina vector... recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged by the UNC vector core facilities... adeno-associated viral ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
82 Vectors of Gene Therapy KATHERINE PARKER PONDER, M.D.
 

Summary:  into a cell are vehicles called vectors. Vectors can be divided into viral and nonviral delivery systems... , and smooth muscle cells. Retroviral vectors have also been used for in vivo delivery. For many organs... CHAPTER 4 Vectors of Gene Therapy KATHERINE PARKER ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
83 An intelligent zone-based delivery scheduling approach H. Wang, D. Xue*
 

Summary:  delivery demands of the 12 months in a year, represented as volumes, are described by a vector: Dj Dj1; Dj... , the average delivery demands in these sub-regions are described by a vector. di di1; di2; . . . ; dim; i 1... in Industry 48 (2002) 109±125 113 #12;The 12 delivery demand ...

  

Source: Xue, Deyi - Department of Mechanical and Manufacturing Engineering, University of Calgary

 

Collection: Engineering

 
84 Imaging living central neurones using viral gene transfer A.G. Teschemachera
 

Summary:  viral vectors into approximately 10 sites in the CA1 and CA3 regions for successful transgene delivery... . As with other viral vectors, SFV and SV used for transgene delivery lack genes encoding for structural proteins... for fluorescent proteins into relevant cellular targets, molecular tools are required. ...

  

Source: Bristol, University of - Department of Physiology and Pharmacology, Viral Gene Transfer Lab.

 

Collection: Biology and Medicine

 
85 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  AAV encoding parkin was produced using the same expression cassette but the vector was packaged using the AAV5... in rAAV2 (experiment 1) or rAAV5 (experiment 2­3) capsids. TR=terminal repeats (B) The sequence... /5 viruses the pDG plasmid was substituted for the pXYZ5 plasmid which ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
86 W W W. N A T U R E . C O M / N A T U R E | 1 SUPPLEMENTARYINFORMATION doi:10.1038/nature10360
 

Summary:  of a 40 µm coronal brain slice from a PV::Cre mouse bilaterally injected with Cre-dependent AAV5-EF1-DIO... injected with AAV5-CaMKII-SSFO-EYFP. Activation with 470 nm light (blue bar) triggered depolarization... /E162T) and AAV5-EF1-DIO-ChR2(H134R). (c) Voltage ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
87 LETTER doi:10.1038/nature09820 Amygdala circuitry mediating reversible and
 

Summary:  transduced with an adeno-associated virus serotype 5 (AAV5) carrying codon-optimized channelrhodopsin (ChR2... YFP plasmids were designed and constructed by standard methods and packaged as AAV5. Virus (0.5 ml... neurons18 to implement anxiolysis. To test this, we undertook in vivo experi- ments, with ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
88 www.sciencemag.org/cgi/content/full/330/6011/1677/DC1 Supporting Online Material for
 

Summary:  ://www.stanford.edu/group/dlab/optogenetics/sequence_info.html. The recombinant AAV vectors were serotyped with AAV5 coat proteins and packaged by the viral vector core... Animals. Virus production As described previously (2, 3), Cre-inducible recombinant AAV vectors were based... -floxed ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
89 ORIGINAL ARTICLE Surface immobilization of hexa-histidine-tagged
 

Summary:  . This immobilized AAV vector system mediates high-efficiency delivery to cells that contact the surface and thus may... . As an alternative, immobi- lizing gene delivery vectors onto material surfaces followed by implantation into target... -mediated delivery places the ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
90 JOURNAL OF VIROLOGY, Mar. 2004, p. 31103122 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.31103122.2004
 

Summary:  Uncoating of Vector Genomes Is the Key to Efficient Liver Transduction with Pseudotyped Adeno... -Associated Virus Vectors Clare E. Thomas, Theresa A. Storm, Zan Huang, and Mark A. Kay* Departments of Pediatrics... (AAV2) vectors is ineffi- cient; less than 10% of hepatocytes are permissive for stable transduction

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
91 RNAi based gene therapy for Spinocerebellar ataxia-7 HHMI Med-Into-Grad Proposal
 

Summary:  , Chiorini, JA and Davidson, BL. Transduction of murine cerebellar neurons with recombinant FIV and AAV5... of viral vector based RNA interference (RNAi) for the mutated allele, is attractive as a potential... treatment for SCA7. The retina is an ideal target for viral vector mediated gene transfer, because

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
92 Characterization of the Relationship of AAV Capsid Domain Swapping to Liver
 

Summary:  -term transgene expression. However, AAV2 vectors are not always the optimal candidate for gene delivery... to AAV-5. Virology 353: 68­82. 11. Nakai, H, Fuess, S, Storm, TA, Muramatsu, S, Nara, Y and Kay, MA (2005... Recombinant adeno-associated virus (AAV) vectors show promise for use ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
93 W W W. N A T U R E . C O M / N A T U R E | 1 SUPPLEMENTARYINFORMATION doi:10.1038/nature10194
 

Summary:  serotyped with AAV5 coat proteins and packaged using calcium phosphate precipitation methods by the UNC... purification, restriction digest, and sequencing to assure DNA fidelity, purified recombinant AAV vectors were... Vector Core facilities (University of North Carolina, Chapel Hill). The final viral ...

  

Source: Deisseroth, Karl - Departments of Psychiatry and Behavioral Sciences & Bioengineering, Stanford University

 

Collection: Biology and Medicine

 
94 Effective Drug Therapies from Functional, Macromolecular Building Blocks with
 

Summary:  to reach this high level of specification we differentiated the macromolecular delivery vector... . Conclusion In summary, we described the development of drug delivery vectors comprised of a Macromol. Symp... * Summary: The development of suitable delivery systems for intracellular ...

  

Source: Harth, Eva M. - Department of Chemistry, Vanderbilt University

 

Collection: Materials Science ; Biology and Medicine

 
95 original article 524 www.moleculartherapy.org vol. 17 no. 3, 524537 mar. 2009
 

Summary:  in the context of the experiments described here. This would, therefore, predict that a rAAV5 capsid encoding... in the second-injection site, this effect is not due to loss of vector genomes as determined by quantitative... , and liver, may require repeated administra- tion of vector to achieve the desired ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
96 Targeted synthetic gene delivery vectors David V Schaffer1
 

Summary:  Targeted synthetic gene delivery vectors David V Schaffer1 & Douglas A Lauffenburger2,3,4 Addresses... delivery vector to mediate surface receptor-mediated binding and internalization to specific cells... can be developed, vectors such as these may find use for targeted ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
97 Neurobiology of Disease Continuous Low-Level Glial Cell Line-Derived Neurotrophic
 

Summary:  ) Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion... Neurobiology of Disease Continuous Low-Level Glial Cell Line-Derived Neurotrophic Factor Delivery... Using Recombinant Adeno-Associated Viral Vectors Provides Neuroprotection and Induces Behavioral

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
98 Sustained Striatal Ciliary Neurotrophic Factor Expression Negatively Affects
 

Summary:  delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic... by recombinant adeno-associated viral vectors (rAAV2). Wild-type and R6/1 HD transgenic (R6/1) mice that received... that rodents as well as humans receiving systemic delivery of CNTF experience weight ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
99 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 17 no. 11, 18571867 nov. 2009 1857
 

Summary:  , enabling longitudinal in vivo tracking of GDNF expression after nigral vector delivery. Regu- lated GDNF... of a series of known GDNF-associated side effects when using direct intrastriatal vector delivery. Therefore... , this single rAAV vector system meets most of the requirements for ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
100 PEG Conjugation Moderately Protects Adeno-Associated Viral Vectors Against
 

Summary:  into the vector to further enhance polymer protection of AAV gene delivery. Future work should include... G, Schaffer DV. 2003. Engineering the surface properties of gene delivery vectors. Luo D, Saltzman... PEG Conjugation Moderately Protects Adeno-Associated Viral Vectors Against ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry


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