| Sample search results for: a30p mutant affect |
| 1 | AjMutator: A Tool For The Mutation Analysis Of AspectJ Pointcut Descriptors | ||
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Summary: is then used by AjMutator to classify the mutants. As a single modification of an aspect can affect var- Aj... a set of mutants. AjMutator classifies the mutants according to the set of joinpoints they match... is that this automatic classification can identify equiva- lent mutants for a ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 2 | AjMutator: A Tool For The Mutation Analysis Of AspectJ Pointcut Descriptors | ||
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Summary: the mutants. As a single modification of an aspect can affect var- AjMutator Mutant Compiler abc Compiler... a set of mutants. AjMutator classifies the mutants according to the set of joinpoints they match... is that this automatic classification can identify equiva- lent ... |
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Source: Jézéquel, Jean-Marc - Triskell Project & IRISA, Université de Rennes |
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Collection: Computer Technologies and Information Sciences |
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| 3 | Effect of Familial Parkinson's Disease Point Mutations A30P and A53T on the Structural Properties, Aggregation, and Fibrillation of Human R-Synuclein | ||
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Summary: - ties between wild-type R-synuclein and its A30P and A53T mutants. The major question is how a single... R-Synucleins. WT R-synuclein and its A30P and A53T mutants were produced and purified by fusing... appears to be the ... |
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Source: Fink, Anthony - Department of Chemistry and Biochemistry, University of California at Santa Cruz |
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Collection: Biology and Medicine |
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| 4 | Investigations of the Software Testing Coupling Effect | ||
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Summary: , affecting the same line). For this experiment, all of the korder mutants were also killed. Although... order mutants, or complex mutants, are mutants that are generated by introducing multiple mutations... into the program, then it is clear that many higherorder ... |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 5 | Conformational Behavior of Human a-Synuclein is Modulated by Familial Parkinson's Disease | ||
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Summary: higher concentrations were required for the A30P mutant. In contrast to the wild-type and A53T proteins... ), the A30P mutant was inhibited by DDC. The mutant proteins had significantly lower affinity for ... |
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Source: Fink, Anthony - Department of Chemistry and Biochemistry, University of California at Santa Cruz |
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Collection: Biology and Medicine |
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| 6 | MUTANT SELECTION WINDOW: LIST OF PUBLICATIONS AND MAJOR STATEMENTS | ||
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Summary: affecting mutant enrichment; mutant selection window as a context for mutant enrichment and ways to slow... mycobacteria. Antimicrob. Agents Chemother. 44: 3337-3343. Fluoroquinolone structure affects the mutant... 1 MUTANT SELECTION WINDOW: LIST ... |
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Source: Kramer, Fred - Public Health Research Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey |
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Collection: Biology and Medicine |
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| 7 | Incomplete dominance for flower colour in Mirabilis jalapa R1 Red pigment | ||
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Summary: ornithine citrulline argenine arg-1 mutant can't make ornithine arg-2 mutant can't make citrulline arg-3... mutant can't make argenine #12;Inferring Gene Interactions The approach to using a genetic analysis... to infer gene interactions involves the following steps: 1. Generate mutants (xrays, uv, EMS etc |
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Source: Shore, Joel S. - Department of Biology, York University (Toronto) |
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Collection: Biology and Medicine |
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| 8 | J. evol. biol. 11 (1998) 389 -401 1010 MIX 98'030389 13 $ 1.50f0.20 0 | ||
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Summary: ], 1998 1Journal of Evolutionary Biology Invasion of rare mutants does not imply their evolutionary... ; multiple attractors. 1. Introduction It is common in evolutionary theory to assumethat a mutant type which... in the resident population in which the mutant's growth rate is measured. The underlying argument goes roughly |
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Source: Doebeli, Michael - Departments of Zoology & Mathematics, University of British Columbia |
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Collection: Biology and Medicine |
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| 9 | Selective loss of dopaminergic neurons and formation of Lewy body-like aggregations in a-synuclein transgenic | ||
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Summary: neuronal cultures expressing a human mutant a-synuclein (a-Syn; A30P). The selective loss of dopaminergic... neurodegen- eration using a transgenic fly line carrying a mutant human a-Syn (A30P) gene. As a first step... ... |
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Source: Lee, Daewoo - Department of Biological Sciences, Ohio University |
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Collection: Biology and Medicine |
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| 10 | Molecular Biology of the Eye: Genes, Vision, and Ocular Disease, pages 45-52 | ||
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Summary: EF deletions affect retinal binding or transducin activation. Mutants in loop AS and the carboxyl... of the activation of transducin by rhodopsin, we have prepared a series of rhodopsin mutants by in vitro site... putative transmembrane helices and in the cyto- plasmic carboxyl-terminal tail of rhodopsin. Three ... |
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Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University |
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Collection: Biology and Medicine |
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| 11 | Automated Generation of Pointcut Mutants for Testing Pointcuts in AspectJ Programs | ||
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Summary: Automated Generation of Pointcut Mutants for Testing Pointcuts in AspectJ Programs Prasanth... of mutants (i.e., varia- tions) for pointcuts is usually large due to the usage of wild- cards. It is tedious... to manually identify effective mutants that are of appropriate strength and resemble closely the original |
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Source: Xie, Tao - Department of Computer Science, North Carolina State University |
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Collection: Computer Technologies and Information Sciences |
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| 12 | An Analysis of OO Mutation Operators Jingyu Hu, Nan Li and Jeff Offutt | ||
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Summary: operators. Results include statistics on the var- ious types of mutants, how many are equivalent, new rules... for avoiding creation of equivalent mutants, the difficulty of killing individual mutants, and the diffi- culty... of killing mutants from the various operators. The paper draws conclusions about ... |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 13 | Expression of A53T Mutant But Not Wild-Type -Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation | ||
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Summary: - ground of PC12 cells, by generating PC12 cell lines expressing the A53T or the A30P mutant or wild... indistinguishable from controls. Cells ex- pressing the A53T or A30P mutant form did not demonstrate the dramatic... of PD ... |
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Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University |
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Collection: Biology and Medicine |
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| 14 | Role of Individual Methionines in the Fibrillation of Methionine-Oxidized R-Synuclein | ||
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Summary: present in cytosol of some surviving nigral neurons in PD brains (9, 10). The mutations A53T and A30P in R... of the fibrillation and ag- gregation rates of WT with those of the familial PD mutations, A30P and A53T, revealed... (A53T) and decreased by the other ... |
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Source: Fink, Anthony - Department of Chemistry and Biochemistry, University of California at Santa Cruz |
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Collection: Biology and Medicine |
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| 15 | Mutation Clustering Shamaila Hussain | ||
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Summary: . The computational cost is due to too many mutants for even small programs. We have experimented with different... to reduce the computational cost of the mutation testing, reducing the number of the mutants by clustering... to cluster the mutants. Thereby, re- ducing the size of mutants by selecting one ... |
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Source: Harman, Mark - Department of Computer Science, King's College London |
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Collection: Computer Technologies and Information Sciences |
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| 16 | An Experimental Determination of Sufficient Mutant Operators | ||
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Summary: An Experimental Determination of Sufficient Mutant Operators A. Jefferson Offutt Ammei Lee George... mutants, must be repeatedly executed. This paper quantifies the expense of mutation in terms of the number... of mutants that are created, then proposes and evaluates a technique that reduces the number of ... |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University; Rothermel, Gregg - Department of Computer Science and Engineering, University of Nebraska-Lincoln |
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Collection: Computer Technologies and Information Sciences |
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| 17 | Neurobiology of Disease -Synuclein Overexpression Increases Cytosolic | ||
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Summary: ., 1991). Cell lines overexpressing human WT or mutant A30P or A53T -synuclein types were generated based... . Moreover, total catechol levels were highest in cells expressing A30P or A53T mutant proteins. Cytosolic... ). ... |
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Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University |
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Collection: Biology and Medicine |
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| 18 | MuJava : An Automated Class Mutation System Yu-Seung Ma1 | ||
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Summary: of mutation testing for OO programs by using two key technologies, Mutant Schemata Generation (MSG... ) and bytecode translation. This method adapts the existing MSG method for mutants that change the program... behavior and uses bytecode translation for mutants that change the program structure. A key advantage |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 19 | On Guiding the Augmentation of an Automated Test Suite via Mutation Mutation testing has traditionally been used as a defect injection technique to assess the effectiveness of a test | ||
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Summary: cases until the test suite is sufficient to detect as many mutants as possible and the mutation score... test cases because their mutants were immediately detected by the initial test suite, indirectly... detected by test suites we added to detect other mutants or were not able to be detected by any test. 1 |
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Source: Reeves, Douglas S. - Department of Computer Science, North Carolina State University |
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Collection: Computer Technologies and Information Sciences |
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| 20 | Neurobiology of Disease -Synuclein Overexpression in PC12 and Chromaffin Cells | ||
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Summary: -syn levels relative to neurons, affects catecholamine release. Overexpression of wild-type or A30P... expression levels of WT and A30P mutant -syn. These cells possess advantages for studies of this type because... therefore ... |
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Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University |
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Collection: Biology and Medicine |
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| 21 | Copyright 2005 by the Genetics Society of America DOI: 10.1534/genetics.104.039727 | ||
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Summary: epithelium, (7) the lens, (8) retinal containment, and (9) behavior. The affected genes in these mutants... @fas.harvard.edu tional mutants of which 315 different affected loci have2 Present address: Department of Biology, Texas A... of the loci affected, fgr and pat, encode #12;252 J. M. ... |
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Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin |
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Collection: Biology and Medicine |
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| 22 | Mutant Minimization for Model-Checker Based Test-Case Generation Gordon Fraser and Franz Wotawa | ||
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Summary: and then use the model-checker to search for paths that show how mutants affect output vari- ables... to be false, this suggests that the considered test-case affects the property and thus the mutant, but does... Mutant Minimization for Model-Checker Based Test-Case Generation Gordon ... |
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Source: Technische Universität Graz, Institute for Software Technology |
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Collection: Computer Technologies and Information Sciences |
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| 23 | THE GENETICS OF CAENORHABDZTZS ELEGANS Medical Research Council Laboratory of Molecular Biology, | ||
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Summary: . In general, the pulsating pharyngeal movements are not affected in the mutants, even in severely paralyzed... . In some paralyzed and semiparalyzed mutants the vulva is also affected, and eggs are not laid. Prog- eny... are described for the isolation, complementation and mapping of ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 24 | How the Lac Repressor regulates the lac operon I. Defining the binding site | ||
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Summary: defines binding site in vitro b. lac o mutants define the binding site in vivo II. Defining the DNA... " What does this suggest about the LacR?" #12;The lacOc mutants map to DNA protected in footprint" Rare... laci-d mutants are constitutive, and dominant! What molecular mechanism could explain this genetic |
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Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College |
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Collection: Biology and Medicine |
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| 25 | INTRODUCTION Following gastrulation, vertebrate embryos can be | ||
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Summary: in hindbrain organization of the single and double mutants and the associated neural crest, affected... mutants restore normal palatogenesis Case 1. Defects in the tubotympanic recess of Hoxa2 affect... interactions between these tissues. Any change that alters this ordered arrangement profoundly ... |
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Source: Capecchi, Mario R. - Department of Biology, University of Utah |
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Collection: Biology and Medicine |
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| 26 | 461 Rapid Science Ltd ISSN 0269-9370 Introduction | ||
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Summary: of intermediate mutants with positive growth rate not only strongly affects the equilibrium frequency of a n... cell count [15]. Monotherapy often leads to rapid emergence of drug-resistant virus mutants. For some... on whether resistant mutant virus is present before the initiation of therapy [9,10]. If ... |
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Source: Bonhoeffer, Sebastian - Institut für Integrative Biologie, Eidgenössische Technische Hochschule Zürich (ETHZ); Nowak, Martin A. - Department of Organismic and Evolutionary Biology, Harvard University |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 27 | Mutation Testing of Software Using a MIMD Computer A. Jefferson Offutt | ||
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Summary: . A factor that affects both speedup and efficiency is the variability in the number of mutants interpreted... of which produces a set of executable variations, called mutants, of the original program. Test cases... are used to cause the mutants to gen erate incorrect output. Mutant ... |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 28 | Gene Regulation! How do multicellular organisms make such radically different | ||
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Summary: gene will affect the expression of all the genes controlled by the regulatory gene! Regulatory mutants... required to metabolize lactose? " 1st step= isolate mutants in lactose metabolism. How?! What phenotype... will these mutants have?! How will you distinguish them from mutants in the ... |
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Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College |
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Collection: Biology and Medicine |
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| 29 | Automated screening for mutants affecting | ||
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Summary: Automated screening for mutants affecting dopaminergic-neuron specification in C. elegans Maria... allele per 10 d 1 allele per 1.5 d aAs these two mutants only affect gfp expression in the two PDE... : individual mutants had distinct subsets of dopaminer- gic neurons ... |
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Source: Hobert, Oliver - Department of Biochemistry and Molecular Biophysics, Columbia University |
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Collection: Biology and Medicine |
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| 30 | JOURNAL OF BACTERIOLOGY, 0021-9193/00/$04.00 0 | ||
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Summary: of transcriptional repressors. To understand how RosR affects these phenotypes, we mutagenized a rosR mutant... trait. Identification of mutants affected in competitiveness is challenging in many microbial systems... rosR in trans affected nodula- tion competitiveness in the ... |
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Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 31 | INTRODUCTION Formation of the vertebrate neural plate, and generation of cell | ||
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Summary: in the mid- and hindbrain. Later development of the floor plate is affected in mutant chameleon, you... ). In our screen for mutants affecting embryonic development of the zebrafish, we have recovered many... for embryonic visible mutants in the zebrafish, we found 113 mutations defining ... |
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Source: Karlstrom, Rolf O. - Department of Biology, University of Massachusetts at Amherst |
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Collection: Biology and Medicine |
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| 32 | 20/11/2007 18:16Faculty of 1000 Biology | Cooperation and conflict in quorum-sensing bacterial populations. Page 1 of 2http://www.f1000biology.com/article/id/1095043 | ||
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Summary: this environment favoring survival and spread of QS mutants. These findings should profoundly affect the thinking... communicate and cooperate in QS-based behaviors might be exploited by mutants that can avoid the cost... of cooperation. In this study, they showed that QS-mutant cells that either did not ... |
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Source: West, Stuart - School of Biological Sciences, University of Edinburgh |
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Collection: Environmental Sciences and Ecology |
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| 33 | Using Compiler Optimization Techniques to Detect Equivalent Mutants | ||
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Summary: Using Compiler Optimization Techniques to Detect Equivalent Mutants A. Jefferson Offutt \Lambda... differing versions, called mutants, of the same program to evaluate the quality of the data used to test... the program. Although these mutants are generated and executed efficiently by automated methods, many |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 34 | Surface Mechanics Mediate Pattern Formation in the | ||
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Summary: configurations? #12;Methods #1 The Roi (Rough eye) mutants! #12;Roi Genetics Roi is an allele of amos amos gene... the normal complement of photoreceptor cells #12;Applying Plateau to Mutants (Recap) Are surface... -area minimization forces working on the Roi mutants? #12;Evidence to Validate Plateau Do cone cells: Aggregate |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 35 | INTRODUCTION The majority of nutritional storage in cereal grains occurs in | ||
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Summary: found where the surface ridge-work typical of mutant cells affected only part of a cell's surface. Fig... . 4A,B shows an example where partially affected cells occur neighboring files of mutant cells. Fig. 4... cell fate acquisition in endosperm development. Maize dek1 mutants lack ... |
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Source: Becraft, Philip W. - Department of Genetics, Development and Cell Biology, Iowa State University |
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Collection: Biotechnology ; Biology and Medicine |
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| 36 | DEVELOPMENTAL BIOLOGY 192, 274288 (1997) ARTICLE NO. DB978765 | ||
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Summary: Homozygous Mutants Are Viable and have overlapping phenotypes, the Hoxb3 mutation does Fertile weakly affect... and Hoxd3 revealed that these genes interact synergistically to affect the develop-that these mutant... seen in the Hoxa3 mutant and affected only a tants ... |
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Source: Capecchi, Mario R. - Department of Biology, University of Utah |
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Collection: Biology and Medicine |
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| 37 | Copyright 2000 by the Genetics Society of America Genetic Analysis of Isometric Growth Control Mechanisms in the | ||
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Summary: is affected in lof mutants: To determine how often fin ray segments are initiated and (2) mecha- if the lof... mutants affect the number of seg- length of the third fin ray in sof mutants. Therefore... mech- anisms affecting G and R phases may be regulated ... |
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Source: Lehigh University, Department of Biological Sciences; Mullen, Sean P. - Department of Biological Sciences, Lehigh University |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 38 | nature neuroscience volume 5 no 4 april 2002 301 Amyotrophic lateral sclerosis (ALS), a progressive, fatal neurode- | ||
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Summary: lacking CCS were indistinguishable from the respective SOD1- mutant mice expressing CCS. Affected mice... of CCS does not affect the onset of motor neuron disease or lifespan in G37R, G93A and G85R mutant mice... - oxide toxicity1,2. A variety of studies, including investigations of ... |
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Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University |
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Collection: Biology and Medicine |
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| 39 | Current Biology 19, 341345, February 24, 2009 2009 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2009.01.050 Quorum Sensing and the Social Evolution | ||
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Summary: -sensing bacteria and mutants that do not respond to signal, virulence in an animal (mouse) model is reduced... relative to that of an infec- tion containing no mutants. We show that this is because mutants act... increase in frequency. This supports the idea that the invasion of QS mutants in infections of ... |
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Source: West, Stuart - School of Biological Sciences, University of Edinburgh |
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Collection: Environmental Sciences and Ecology |
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| 40 | Synergistic interaction between Gdf1 and Nodal during anterior axis development | ||
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Summary: was absent in the most severely affected Gdf1-/- ;Nodal+/- mutant embryos (Figs. 2H, I). At E9, expression... ). Although expression of Krox-20 in rhombomeres 3 and 5 appeared normal even in the most affected mutants... in the mutants (Fig. 3F). Thus, while the Gdf1-/- ;Nodal+/- mutation ... |
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Source: Ibáñez, Carlos - Department of Neuroscience, Karolinska Institutet |
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Collection: Biology and Medicine |
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| 41 | Laminin 1 and 1 Containing Laminins Are Essential for Basement Membrane Integrity in the Zebrafish Eye | ||
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Summary: . Like colobomas, lens dysplasias were also bilateral in nearly all affected mutants. 2484 Lee and Gross... it was also affected in these mutants. We specifically examined Bruch's membrane regions outside of the area... in lamb1 and lamc1 mutants may therefore reflect cell fate changes ... |
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Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin |
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Collection: Biology and Medicine |
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| 42 | Accumulation of mutants in ``aging'' bacterial colonies is due to growth under selection, | ||
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Summary: Accumulation of mutants in ``aging'' bacterial colonies is due to growth under selection... -induced mutation. In one prominent system, mutants resistant to rifampicin (RifR; rpoB; RNA polymerase) accumulate... in cell populations that ``age'' on solid medium with little net growth. Mutant accumulation was initially |
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Source: California at Davis, University of - Center for Genetics and Development, Roth Laboratory |
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Collection: Biology and Medicine ; Biotechnology |
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| 43 | MuJava: A Mutation System for Java Yu-Seung Ma | ||
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Summary: - teria, by using mutants as a method to create faults. In effect, mutation is often used as a "gold... both method-level mutants and class-level mu- tants. MuJava can be freely downloaded and installed... . Faults are introduced into the program by creating a set of faulty versions, called mutants |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 44 | Removal of Pax6 Partially Rescues the Loss of Ventral Structures in Shh Null Mice | ||
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Summary: . We have previously shown that dorsoventral patterning defects seen in Shh2/2 mutants are rescued... in Shh2/2 ;Gli32/2 compound mutants. Here we investigate if the loss of Pax6 can also ameliorate defects... seen in Shh2/2 mutants. In support of this notion, we observe that the fusion of the cerebral vesicles |
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Source: Fishell, Gordon - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University |
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Collection: Biology and Medicine |
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| 45 | 1) Molecular Biology of Plants, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands | ||
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Summary: pathway. Such mutants may have a mutation that more specifically affects the senescence syndrome... affect other aspects of plant growth apart from the late senescence phenotype. Thus, the old mutants were... effective, certainly in Arabidopsis (Lim et al., 2007). Mutants ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 46 | Proc. Nail. Acad. Sci. USA Vol. 88, pp. 3079-3083, April 1991 | ||
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Summary: . Spectrophotometric titrations of the mutants showed that the amino acid at position 113 affected the p... was not affected in COS cell rhodopsin (Rho) (A) and mutant E113D (B). In mutants E113Q (C) and E113A (E... ABSTRACT Glu-113serves as the retinylidene Schiff base counterion in ... |
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Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University |
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Collection: Biology and Medicine |
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| 47 | Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A | ||
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Summary: period (in some hosts) might affect mutant invasion when the full annual dynamics, including epidemic... Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A Julia... dramatic invasions of cytotoxic T lymphocyte escape mutants in human influenza A. In particular, we ... |
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Source: Grenfell, Bryan - Department of Zoology, University of Cambridge |
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Collection: Environmental Sciences and Ecology |
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| 48 | The Plant Cell, Vol. 4, 283-295, March 1992 O 1992American Society of Plant Physiologists Evidence for Nuclear Control of the Expression of the atpA | ||
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Summary: and thm24) affected in the synthe- sis of the a and/orp subunits. The phenotypeof these mutants pointed... mutants of Chlamydomonas reinhardtii altered in the expression of the chloroplast genes atpA or atp... B coding for the a or p subunit of the chloroplast ATP synthase. These mutants revealed the ... |
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Source: Wollman, Francis-André - nstitut de Biologie Physico-Chimique & Université Pierre-et-Marie-Curie, Paris 6 |
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Collection: Biology and Medicine ; Renewable Energy |
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| 49 | 2461DEVELOPMENT AND STEM CELLS RESEARCH ARTICLE INTRODUCTION | ||
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Summary: of Tsc1/2 mutant GSC is due to hyperactivation of TORC1. One well-studied mechanism for GSC maintenance... of marbles (bam) in GSCs. In Tsc1/2 mutant GSCs, BMP signalling activity is downregulated, but bam expression... is still repressed. Moreover, Tsc1 bam double mutant GSCs could differentiate into early cystocytes |
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Source: National Institute of Biological Sciences, Beijing |
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Collection: Biology and Medicine |
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| 50 | TANMEI/EMB2757 Encodes a WD Repeat Protein Required for Embryo Development in Arabidopsis1 | ||
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Summary: mutant embryos differed significantly from wild type. tan Mutation Affects the Maturation Program We... -type immature seeds ger- minated. Thus, the tan mutation appears to affect dormancy, although mutant seeds were... defects in both embryo and seedling development. tan mutant embryos ... |
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Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles |
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Collection: Biology and Medicine |
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| 51 | Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive | ||
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Summary: . Unlike previously known root ethylene-insensitive mutants, wei2 and wei3 were not affected... used extensively for genetic screens to identify Arabidopsis mutants affected in hormone biosynthesis... or sensitivity have also been found to affect the response to ethylene (8, 11). In these ... |
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Source: Ausubel, Frederick M. - Department of Genetics, Harvard University |
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Collection: Biology and Medicine |
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| 52 | An Experimental Evaluation of Selective Mutation A. Jefferson Offutt Gregg Rothermel | ||
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Summary: of mutation is that many variants of the test program, called mutants, must be repeatedly executed. Selective... mutation is a way to approximate mutation test ing that saves execution by reducing the number of mutants... programs are mutants of the original, and a mutant is killed when a test case causes ... |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University; Rothermel, Gregg - Department of Computer Science and Engineering, University of Nebraska-Lincoln |
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Collection: Computer Technologies and Information Sciences |
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| 53 | Immune and Evolutionary Approaches to Software Mutation Testing | ||
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Summary: , with effectiveness measured by the number of mutant executions needed to achieve a specific mutation score. Results... the process. Mutagens Input test prog, P FalseTrue Quit TrueFalse Prog Tests Create mutants Input test cases... , T Run T on P Fix P All mutants dead? Analyse and mark equivalent mutants ... |
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Source: Timmis, Jon - Departments of Computer Science & Electronics, University of York (UK) |
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Collection: Computer Technologies and Information Sciences |
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| 54 | The Yeast VRG4 Gene Is Required for Normal Golgi Functions and Defines a New Family of Related Genes* | ||
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Summary: - way (5). The alg mutants are affected primarily in the synthe- sis of the core oligosaccharide... was in Spurr's resin. RESULTS Isolation of the vrg4 Mutant--We wished to isolate yeast mutants that affect... yeast mutants with Golgi-specific glycosylation defects to ... |
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Source: Dean, Neta - Department of Biochemistry and Cell Biology, SUNY at Stony Brook |
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Collection: Biology and Medicine |
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| 55 | 2006 Nature Publishing Group Drosophila pink1 is required for mitochondrial | ||
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Summary: localizes to mitochondria, and mitochondrial cristae are frag- mented in pink1 mutants. Expression of human... of pink1 mutants, demonstrating func- tional conservation between human and Drosophila Pink1. Loss... rescues the male sterility and mitochondrial morphology defects of pink1 mutants, whereas double ... |
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Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles; Hay, Bruce A. - Division of Biology, California Institute of Technology |
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Collection: Biology and Medicine |
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| 56 | DEVELOPMENT 2981RESEARCH ARTICLE | ||
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Summary: of five of the possible six mutant alleles were much less affected than the paralogous mutants (Fig. 4A... between adjacent paralogous mutants are highlighted in yellow). Within the overlapping affected regions... transformations in paralogous mutants are in red. ... |
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Source: Capecchi, Mario R. - Department of Biology, University of Utah |
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Collection: Biology and Medicine |
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| 57 | RESEARCH ARTICLE Dscam mutation leads to hydrocephalus and | ||
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Summary: mutant mice prompted us to test the hypothesis that the Dscam mutation may affect the formation and... mutant brains exhibited obvious ventricular dilation, although severities and the affected regions varied... that Dscamdel17 mutant mice exhibit severe hydrocephalus, decreased motor ... |
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Source: Wu, Jane Y. - Center for Genetic Medicine & Department of Neurology, Northwestern University |
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Collection: Biology and Medicine |
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| 58 | SHORT COMMUNICATION The N-terminal fragment of Arabidopsis photomorphogenic | ||
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Summary: mutants of COP1 into cop1 null mutant backgrounds, we show that all three domains are essential... to environmental cues. Light is one of the most important factors affecting plant development, as shown... - tropic phenotype of cop1 mutants. In this paper, we examine the functional property of ... |
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Source: Deng, Xing-Wang - Department of Molecular Biophysics and Biochemistry, Yale University |
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Collection: Biology and Medicine ; Biotechnology |
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| 59 | The Relationship Between Program Dependence and Mutation Analysis Mark Harman, Sebastian Danicic, | ||
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Summary: in the mutant and the original program. Those which are interesting may potentially affect the outcome... We can improve on this, however. A `killing state' must also affect the mutant at node n, otherwise... .Hierons@brunel.ac.uk Keywords: Slicing, Dependence Analysis, Test Data Generation, Equivalent ... |
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Source: Harman, Mark - Department of Computer Science, King's College London |
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Collection: Computer Technologies and Information Sciences |
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| 60 | JOURNAL OF BACTERIOLOGY, Apr. 2007, p. 31983207 Vol. 189, No. 8 0021-9193/07/$08.00 0 doi:10.1128/JB.01833-06 | ||
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Summary: suggests that either the residues affected in class 3 mutants are not as critical as those in class 1... mutants are nonpiliated, and thus, all pilus-dependent functions are eliminated. Mutagenesis was performed... on the middle one-third of pilQ, and mutants with colony morphologies consistent with the ... |
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Source: Seifert, Hank - Department of Microbiology-Immunology, Northwestern University |
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Collection: Biology and Medicine |
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| 61 | Selective inhibitors of death in mutant huntingtin cells | ||
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Summary: be valuable tools for investigating the mechanisms by which mutant htt affects caspases and induces neuronal... Selective inhibitors of death in mutant huntingtin cells Hemant Varma1, Cindy Voisine2, C Todd De... of cell death in mutant huntingtinexpressing cells. Four compounds were active in diverse HD ... |
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Source: Stockwell, Brent R. - Department of Biological Sciences, Columbia University |
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Collection: Biology and Medicine |
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| 62 | Higher Order Mutation Testing Yue Jia and Mark Harman | ||
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Summary: mutants, created by the injection of a single fault. Often these first order mutants denote trivial faults... that are easily killed. Higher order mutants are created by the insertion of two or more faults. The paper... introduces the concept of a subsuming HOM; one that is harder to kill than the first order ... |
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Source: Harman, Mark - Department of Computer Science, King's College London |
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Collection: Computer Technologies and Information Sciences |
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| 63 | Plant, Cell and Environment (2006) 29, 13791387 doi: 10.1111/j.1365-3040.2006.01519.x 2006 The Authors | ||
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Summary: growth, indicating that this function is dif- ferent from the functions affected in other gtr mutants... mutants affected in their response to gravity have been isolated.With the estab- lishment of a detailed... .j.cove@leeds.ac.uk Agravitropic mutants of the moss Ceratodon purpureus do ... |
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Source: Quatrano, Ralph S. - Department of Biology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 64 | Selection of Antibiotic Resistance CID 2001:33 (Suppl 3) S147 S U P P L E M E N T A R T I C L E | ||
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Summary: Restricting the Selection of Antibiotic-Resistant Mutants: A General Strategy Derived from Fluoroquinolone... with fluoroquinolones have led to a general method for restricting the selection of antibiotic-resistant mutants... resistance mutations for growth. That concentration has been called the "mutant prevention concentration |
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Source: Kramer, Fred - Public Health Research Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey |
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Collection: Biology and Medicine |
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| 65 | AN EVALUATION OF MUTATION OPERATORS FOR EQUIVALENT MUTANTS | ||
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Summary: AN EVALUATION OF MUTATION OPERATORS FOR EQUIVALENT MUTANTS By Maryam Umar Supervised By Mark Harman... Mark Harman with the proposition to work on the problem of equivalent mutants. I was told that that I... mutation operators are used to create these faulty programs. These programs are called mutants. The ... |
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Source: Harman, Mark - Department of Computer Science, King's College London; Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 66 | Software-based Testing of Sequential VHDL Descriptions M. Scholiv1 | ||
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Summary: , called "mutants". One mutant is generated by injecting one single fault in the original program; a fault... of three main tasks: Mutant generation, Test data generation, Test evaluation. TEST DATA EVALUATION § 2... .3 TEST DATA GENERATION § 2.2 MUTANT GENERATION § 2.1 Modified Mutants ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 67 | Software-based Testing of Sequential VHDL Descriptions M. Scholiv1 | ||
|
Summary: , called "mutants". One mutant is generated by injecting one single fault in the original program; a fault... of three main tasks: Mutant generation, Test data generation, Test evaluation. TEST DATA EVALUATION § 2... .3 TEST DATA GENERATION § 2.2 MUTANT GENERATION § 2.1 Modified Mutants ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 68 | Copyright 2002 by the Genetics Society of America Temperature-Sensitive Paralytic Mutants Are Enriched For Those Causing | ||
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Summary: Copyright 2002 by the Genetics Society of America Temperature-Sensitive Paralytic Mutants... . The availability of a large collection of mutants exhibiting neuro- degeneration will provide a valuable resource... to elucidate these mechanisms. We have developed an effective screen for isolating neurodegeneration mutants |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 69 | Automatically Detecting Equivalent Mutants and Infeasible Paths \Lambda A. Jefferson Offutt | ||
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Summary: Automatically Detecting Equivalent Mutants and Infeasible Paths \Lambda A. Jefferson Offutt ISSE... is a partial solution to the problem of automatically detecting equivalent mutant programs. Equivalent mutants... equivalent mutants is a specific instance of a more general problem, commonly called the ... |
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Source: Offutt, Jeff - Department of Computer Science, George Washington University |
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Collection: Computer Technologies and Information Sciences |
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| 70 | INDUCTION AND SEGREGATION OF CHLOROPLAST MUTATIONS IN VEGETATIVE CELL CULTURES OF | ||
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Summary: of forming such mutant colonies. In contrast, cells among the same cultures with reduced nuclear mutations... the pattern(s) by which an induced mutant allele is transmitted to daughter cells during vegetative division... . If there is good reason to believe that the mutant allele, or the cells containing it, are not at a ... |
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Source: Haughn, George - Department of Botany, University of British Columbia |
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Collection: Biology and Medicine |
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| 71 | Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1 | ||
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Summary: -selection equilibrium, fitness interactions between mutations will affect the frequency of individual mutants within... than expected for PBMC. Epistasis affects the relative abundance of drug-resistant HIV-1 mutants... , the relative mutant frequencies are around 1028 to 1029 and ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 72 | Development/Plasticity/Repair Independent Functions of SlitRobo Repulsion and Netrin | ||
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Summary: ). For example, double mutants between slit and Netrin (the ligands) or robo and fra (the receptors) were... reported to result in phenotypes that were indistinguishable from single Netrin and fra mutants, leading... instead it is solely required to inhibit Netrin-mediated attraction. Analysis of multiple double-mutant |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 73 | Vitamer Levels, Stress Response, Enzyme Activity, and Gene Regulation of Arabidopsis Lines Mutant in the | ||
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Summary: . 4). Expression of the de novo pathway PDX1 genes also was affected in the pdx3 and sos4 mutant lines... than 2-fold in all mutants. Expres- sion of the de novo pathway gene PDX2 was not dramatically affected... as sos4 mutant plants. The growth of pdx3 mutant plants ... |
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Source: Daub, Margaret - Center for Integrated Fungal Research & Department of Plant Biology, North Carolina State University |
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Collection: Biotechnology ; Biology and Medicine |
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| 74 | The Plant Cell, Vol. 9, 2159-2170, December 1997O 1997American Society of Plant Physiologists Disruption of.Interfascicular Fiber Differentiationinan | ||
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Summary: stem elongation and fiber differentiation,a GA-insensi- tive wheat mutant affected stem height... Disruption of.Interfascicular Fiber Differentiationinan Arabidopsis Mutant RuiqinZhong,a Jennifer J. Taylor... , we isolated an interfascicular fiber mutant (ifll) by screening ethyl methanesulfonate- mutagenized |
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Source: Ye, Zheng-Hua - Department of Plant Biology, University of Georgia |
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Collection: Biology and Medicine |
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| 75 | Using and Improving Requirement Properties for Mutation Based Test-Case Generation | ||
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Summary: -based coverage measurement to allow symbolic test-case execution and determine the mutant score of any test... . Test cases are then supposed to detect the difference between original and mutant. Originally, mutation... the mutant differs, and can be transformed to test-cases. 2.2.1 Mutating the Reflected Model Ammann and Black |
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Source: Technische Universität Graz, Institute for Software Technology |
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Collection: Computer Technologies and Information Sciences |
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| 76 | 2601RESEARCH ARTICLE INTRODUCTION | ||
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Summary: . Additionally, an insertional mutation affecting adss has been reported and, phenotypically, adsshi3081 mutants... ) (Johnstone et al., 1985; Long et al., 2006). Each of these de novo pathway mutants shows a subset... mutants possess defects in R-cell axon pathfinding (Long et al., 2006). Developmental roles ... |
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Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin |
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Collection: Biology and Medicine |
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| 77 | Mono-and double-mutant mouse models of Parkinson's disease display severe | ||
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Summary: Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage... and parkin on mitochondrial integrity and function, we have generated several mono-mutant mouse lines... deletion of Parkin (Parkin-Exon3-knockout). Both mouse lines were crossed to generate the double-mutant |
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Source: Lübbert, Hermann - Fakultät für Biologie, Ruhr-Universität Bochum |
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Collection: Biology and Medicine |
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| 78 | Copyright 0 1994 by the Genetics Society of America Altered Regulatory Responses to Glucose Are AssociatedWith a Glucose | ||
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Summary: or grrlA single mutants (Figure 2). These findings suggest that GRRl affects glucose transport by a SNF3... Are AssociatedWith a Glucose Transport Defect in grl Mutants of Saccharomyces cerevisiae Laura G. Vallier... .We presenta kineticanalysisshowingthat thegrrl mutant is also defective in high affinity ... |
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Source: Vallier, Laura - Department of Biology, Hofstra University |
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Collection: Biology and Medicine |
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| 79 | HISTIDINE MUTANTS REQUIRING ADENINE: SELECTION OF MUTANTS WITH REDUCED hisG EXPRESSION IN | ||
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Summary: directly affect purine biosynthesis. This class of mutants was not analyzed further. The adenine... HISTIDINE MUTANTS REQUIRING ADENINE: SELECTION OF MUTANTS WITH REDUCED hisG EXPRESSION... of Salmonella typhimurium mutants with reduced levels of hisG enzyme activity. This method is based ... |
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Source: California at Davis, University of - Center for Genetics and Development, Roth Laboratory |
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Collection: Biology and Medicine ; Biotechnology |
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| 80 | Molecular Biology of the Cell Vol. 8,1481-1499, August 1997 | ||
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Summary: Molecular Biology of the Cell Vol. 8,1481-1499, August 1997 Yeast Actin Cytoskeleton Mutants... mutants accumulate large secretory vesicles and exhibit phenotypes consistent with defects in polarized... (also known as the END4 gene), previously found to affect both the organization of the actin |
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Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University |
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Collection: Biology and Medicine |
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| 81 | Homeostasis of Synaptic Transmission in Drosophila with Genetically Altered Nerve Terminal Morphology | ||
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Summary: varicosities in the mutant. Ultrastructural analysis reveals that mutant nerve terminals have bigger synapses... in synaptic complex- ity provide for more transmitter release at mutant varicosities. These results show... channels and second-messenger systems has been shown to affect arborization of NMJs in ... |
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Source: Stewart, Bryan - Department of Biology, University of Toronto at Mississauga |
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Collection: Environmental Sciences and Ecology |
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| 82 | MILU : A Customizable, Runtime-Optimized Higher Order Mutation Testing Tool for the Full C Language | ||
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Summary: a novel `test harness' technique to embed mutants and their associated test sets into a single... , called mutants, is generated by small changes to the original program p. A transformation rule that gener... - ates a mutant from the original program is known as a muta- tion operator. Mutants can be ... |
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Source: Harman, Mark - Department of Computer Science, King's College London |
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Collection: Computer Technologies and Information Sciences |
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| 83 | Original Paper Dev Neurosci 2002;24:262271 | ||
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Summary: mutant sHW rats show cellular degeneration in the hilar region affecting specifically the pyramidal cells... as a model of neuronal degeneration. Mutant sHW rats display a number of developmental abnormali- ties... and hippocam- pal Fos protein expression in these animals indicated that mutants develop ... |
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Source: Cohen, Randy W. - Department of Biology, California State University, Northridge |
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Collection: Biology and Medicine |
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| 84 | Introduction In recent years, many of the genes that are involved in early | ||
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Summary: ossification centers at the distal ends of the radius and ulna is severely affected in mice with three mutant... studies have shown that Hoxc8, Hoxd11 and Hoxd13 can affect chondrocyte proliferation or cartilage... . For example, in mice mutant for Hoxa10, Hoxc10 and Hoxd10, or mutant for ... |
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Source: Capecchi, Mario R. - Department of Biology, University of Utah |
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Collection: Biology and Medicine |
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| 85 | INTRODUCTION Vertebrate Hox genes are known to play an important role in | ||
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Summary: Nkx3.1 expression is affected in Hoxb13 mutants and propose that in Hoxb13 homozygous mutants... of p12 in the seminal vesicle is not affected in Hoxb13 homozygous mutants. (C) Coomassie Blue stained... -of-function mutants (Kondo et al., 1997; Podlasek et al., 1997; ... |
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Source: Capecchi, Mario R. - Department of Biology, University of Utah |
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Collection: Biology and Medicine |
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| 86 | KNOCK-OUT OF THE MG PROTOPORPHYRIN IX METHYLTRANSFERASE GENE IN ARABIDOPSIS: EFFECTS ON | ||
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Summary: (20). We analyzed how these proteins are affected in the chlm mutant. Immunoblot analysis showed... protoporphyrin IX methyltransferase (CHLM) knock-out mutant in Arabidopsis in which the mutation induces... in the chlm mutant provides an independent indication that Mg protoporphyrin IX is a negative ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 87 | Proc. Nat. Acad. Sci. USA Vol. 68, No. 9, pp. 2112-2116, September 1971 | ||
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Summary: three rhythm mutants isolated, having very different phenotypes, all affect the same func- tional gene... Proc. Nat. Acad. Sci. USA Vol. 68, No. 9, pp. 2112-2116, September 1971 Clock Mutants of Drosophila... ABSTRACT Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. ... |
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Source: Vosshall, Leslie - L:aboratory of Neurogenetics and Behavior, Rockefeller University |
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Collection: Biology and Medicine |
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| 88 | RESEARCH ARTICLE Open Access Regulation of endocytic trafficking of transferrin | ||
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Summary: . These results suggest that the E50K mutant affects Rab8- mediated transferrin receptor trafficking. Conclusions... by overexpression of D474N or E50K-D474N mutant suggesting that these mutants possibly do not affect the function... mutant ... |
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Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development |
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Collection: Biology and Medicine |
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| 89 | Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin | ||
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Summary: selectiv- ity for particular cellular membranes in vivo. Two Syn point mutants (A53T and A30P... Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein Stephen... -wide screens were performed in yeast to identify genes that enhance the toxicity of a ... |
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Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 90 | Journal of Theoretical Biology 236 (2005) 335348 Spatial invasion by a mutant pathogen | ||
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Summary: for that particular mutant affect the dynamics of invasion. In addition, a host can be infected by only one pathogen... is in determining how the parameters affect the ability of the mutant pathogen to invade when it arises at low... Journal of Theoretical Biology 236 (2005) 335348 Spatial invasion by a ... |
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|
Source: Krone, Steve - Department of Mathematics, University of Idaho |
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Collection: Mathematics |
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| 91 | The Effects of Amino Acid Replacements of Glycine 121 on Transmembrane Helix 3 of Rhodopsin* | ||
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Summary: replacements that affect the Schiff base envi- ronment have been shown to decrease the stability of mutant... prepared a set of seven single amino acid replacement mutants of rhodopsin at posi- tion 121 (G121A, Ser... , Thr, Val, Ile, Leu, and Trp) and control mutants with replacements of Gly114 or Ala117 . ... |
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Source: Smith, Steven O.- Department of Biochemistry and Cell Biology, SUNY at Stony Brook |
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Collection: Biology and Medicine |
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| 92 | Transformation of the Collateral Vascular Bundles into Amphivasal Vascular Bundles in an Arabidopsis Mutant1 | ||
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Summary: . A number of mutants affecting formation of midvein or minor veins in leaves have been isolated in grasses... so far affect vascular differentiation or leaf venation. To our knowl- edge, no mutants with a global... al., 1997). These mutants appeared not to affect the ... |
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Source: Ye, Zheng-Hua - Department of Plant Biology, University of Georgia |
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Collection: Biology and Medicine |
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| 93 | Bioinformatics Rapid Classification of Phenotypic Mutants of | ||
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Summary: provides information about the underlying processes affected in such mutants. Metabolite profiles... sex mutants are most likely to be genuinely affected in the pathway of starch breakdown. RESULTS... , known mutants affected in starch metabolism (e.g. sex4; Fig. 3) ... |
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Source: Partovi Nia, Vahid - Department of Mathematics and Statistics, McGill University |
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Collection: Mathematics |
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| 94 | JOURNAL OF VIROLOGY, Jan. 1992, p. 505-511 0022-538X/92/010505-07$02.00/0 | ||
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Summary: otherwise defective mutants containing random hydrophobic sequences. However, a class of mutants... appear to display increased homodimer formation compared with mutant proteins lacking the glutamine... subjected to detailed mutational analysis. Initial studies of mutants containing amino acid substitutions |
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Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University |
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Collection: Biology and Medicine |
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| 95 | Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens | ||
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Summary: phenotype is variable. Mildly affected uhrf1 mutant lenses (~50%) show anterior lens opacifications (Figs. 2... affected mutants (~50%) the lens often ruptures through the lens capsule and becomes ectopically localized... mutants have similar lens phenotypes to uhrf1 and dnmt1 single ... |
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|
Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin |
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Collection: Biology and Medicine |
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| 96 | Improved Thermostability of Bacillus circulans Cyclodextrin Glycosyltransferase by the Introduction of a | ||
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Summary: with those from T. thermosulfurigenes CGTase, a B. circulans CGTase mutant (with N188D and K192R mutations... - sulfurigenes CGTase. Structural analysis of the B. circulans CGTase mutant revealed that this salt... -bridge is also formed in the mutant. Because the mutations are located in the B-domain, this result also |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 97 | The Vacuolar-ATPase Complex Regulates Retinoblast Proliferation and Survival, Photoreceptor | ||
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Summary: as a sixth mutant in which a v-ATPase associated protein (atp6ap1) was affected. METHODS. v-ATPase mutant... to the affected regions of the RPE. Ultrastructural analyses indicate that RPE cells in v-ATPase mutants possess... not shown). In the RPE, pigmentation levels varied between mu- ... |
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Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin |
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Collection: Biology and Medicine |
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| 98 | Autophosphorylation at Thr286 Calcium-Calmodulin Kinase II | ||
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Summary: - tivity in the mutants but did not affect their CaM-dependent activity (14). The residual Ca... the autophosphorylation of threonine at position 286 ( Thr286 ) of this kinase without affecting its Ca... M-dependent activity. The mutant mice had no N-methyl-D-aspartate receptordependent LTP in the ... |
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|
Source: Silva, Alcino - Department of Neurobiology, University of California at Los Angeles |
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Collection: Biology and Medicine |
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| 99 | Proc. Natl. Acad. Sci. USA Vol. 96, pp. 499504, January 1999 | ||
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Summary: Proc. Natl. Acad. Sci. USA Vol. 96, pp. 499504, January 1999 Cell Biology A Gs mutant designed... a functionally analogous dominant negative G mutation. Here we describe a mutant subunit designed to inhibit... this mutant, we introduced into the subunit ( s) of Gs three separate mutations chosen because they impair |
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|
Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco |
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Collection: Biology and Medicine |
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| 100 | Function of Extracellular Loop 2 in Rhodopsin: Glutamic Acid 181 Modulates Stability and Absorption Wavelength of Metarhodopsin II | ||
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Summary: -like photoproducts of the mutants, Glu181 more significantly affects the environment of the RET Schiff base in MII... a set of site-directed mutants. Sixteen of the 19 single-site mutants expressed and bound 11-cis... -retinal to form pigments. The max value of mutant pigment E181Q showed ... |
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Source: Chang, Belinda - Department of Ecology and Evolutionary Biology, University of Toronto |
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Collection: Biology and Medicine |
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