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Sample search results for: a30p mutant affect

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1 AjMutator: A Tool For The Mutation Analysis Of AspectJ Pointcut Descriptors
 

Summary:  is then used by AjMutator to classify the mutants. As a single modification of an aspect can affect var- Aj... a set of mutants. AjMutator classifies the mutants according to the set of joinpoints they match... is that this automatic classification can identify equiva- lent mutants for a ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
2 AjMutator: A Tool For The Mutation Analysis Of AspectJ Pointcut Descriptors
 

Summary:  the mutants. As a single modification of an aspect can affect var- AjMutator Mutant Compiler abc Compiler... a set of mutants. AjMutator classifies the mutants according to the set of joinpoints they match... is that this automatic classification can identify equiva- lent ...

  

Source: Jézéquel, Jean-Marc - Triskell Project & IRISA, Université de Rennes

 

Collection: Computer Technologies and Information Sciences

 
3 Effect of Familial Parkinson's Disease Point Mutations A30P and A53T on the Structural Properties, Aggregation, and Fibrillation of Human R-Synuclein
 

Summary:  - ties between wild-type R-synuclein and its A30P and A53T mutants. The major question is how a single... R-Synucleins. WT R-synuclein and its A30P and A53T mutants were produced and purified by fusing... appears to be the ...

  

Source: Fink, Anthony - Department of Chemistry and Biochemistry, University of California at Santa Cruz

 

Collection: Biology and Medicine

 
4 Investigations of the Software Testing Coupling Effect
 

Summary:  , affecting the same line). For this experiment, all of the k­order mutants were also killed. Although... ­order mutants, or complex mutants, are mutants that are generated by introducing multiple mutations... into the program, then it is clear that many higher­order ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
5 Conformational Behavior of Human a-Synuclein is Modulated by Familial Parkinson's Disease
 

Summary:  higher concentrations were required for the A30P mutant. In contrast to the wild-type and A53T proteins... ), the A30P mutant was inhibited by DDC. The mutant proteins had significantly lower affinity for ...

  

Source: Fink, Anthony - Department of Chemistry and Biochemistry, University of California at Santa Cruz

 

Collection: Biology and Medicine

 
6 MUTANT SELECTION WINDOW: LIST OF PUBLICATIONS AND MAJOR STATEMENTS
 

Summary:  affecting mutant enrichment; mutant selection window as a context for mutant enrichment and ways to slow... mycobacteria. Antimicrob. Agents Chemother. 44: 3337-3343. Fluoroquinolone structure affects the mutant... 1 MUTANT SELECTION WINDOW: LIST ...

  

Source: Kramer, Fred - Public Health Research Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
7 Incomplete dominance for flower colour in Mirabilis jalapa R1 Red pigment
 

Summary:  ornithine citrulline argenine arg-1 mutant can't make ornithine arg-2 mutant can't make citrulline arg-3... mutant can't make argenine #12;Inferring Gene Interactions The approach to using a genetic analysis... to infer gene interactions involves the following steps: 1. Generate mutants (xrays, uv, EMS etc

  

Source: Shore, Joel S. - Department of Biology, York University (Toronto)

 

Collection: Biology and Medicine

 
8 J. evol. biol. 11 (1998) 389 -401 1010 MIX 98'030389 13 $ 1.50f0.20 0
 

Summary:  ], 1998 1Journal of Evolutionary Biology Invasion of rare mutants does not imply their evolutionary... ; multiple attractors. 1. Introduction It is common in evolutionary theory to assumethat a mutant type which... in the resident population in which the mutant's growth rate is measured. The underlying argument goes roughly

  

Source: Doebeli, Michael - Departments of Zoology & Mathematics, University of British Columbia

 

Collection: Biology and Medicine

 
9 Selective loss of dopaminergic neurons and formation of Lewy body-like aggregations in a-synuclein transgenic
 

Summary:  neuronal cultures expressing a human mutant a-synuclein (a-Syn; A30P). The selective loss of dopaminergic... neurodegen- eration using a transgenic fly line carrying a mutant human a-Syn (A30P) gene. As a first step... ...

  

Source: Lee, Daewoo - Department of Biological Sciences, Ohio University

 

Collection: Biology and Medicine

 
10 Molecular Biology of the Eye: Genes, Vision, and Ocular Disease, pages 45-52
 

Summary:  EF deletions affect retinal binding or transducin activation. Mutants in loop AS and the carboxyl... of the activation of transducin by rhodopsin, we have prepared a series of rhodopsin mutants by in vitro site... putative transmembrane helices and in the cyto- plasmic carboxyl-terminal tail of rhodopsin. Three ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
11 Automated Generation of Pointcut Mutants for Testing Pointcuts in AspectJ Programs
 

Summary:  Automated Generation of Pointcut Mutants for Testing Pointcuts in AspectJ Programs Prasanth... of mutants (i.e., varia- tions) for pointcuts is usually large due to the usage of wild- cards. It is tedious... to manually identify effective mutants that are of appropriate strength and resemble closely the original

  

Source: Xie, Tao - Department of Computer Science, North Carolina State University

 

Collection: Computer Technologies and Information Sciences

 
12 An Analysis of OO Mutation Operators Jingyu Hu, Nan Li and Jeff Offutt
 

Summary:  operators. Results include statistics on the var- ious types of mutants, how many are equivalent, new rules... for avoiding creation of equivalent mutants, the difficulty of killing individual mutants, and the diffi- culty... of killing mutants from the various operators. The paper draws conclusions about ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
13 Expression of A53T Mutant But Not Wild-Type -Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation
 

Summary:  - ground of PC12 cells, by generating PC12 cell lines expressing the A53T or the A30P mutant or wild... indistinguishable from controls. Cells ex- pressing the A53T or A30P mutant form did not demonstrate the dramatic... of PD ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine

 
14 Role of Individual Methionines in the Fibrillation of Methionine-Oxidized R-Synuclein
 

Summary:  present in cytosol of some surviving nigral neurons in PD brains (9, 10). The mutations A53T and A30P in R... of the fibrillation and ag- gregation rates of WT with those of the familial PD mutations, A30P and A53T, revealed... (A53T) and decreased by the other ...

  

Source: Fink, Anthony - Department of Chemistry and Biochemistry, University of California at Santa Cruz

 

Collection: Biology and Medicine

 
15 Mutation Clustering Shamaila Hussain
 

Summary:  . The computational cost is due to too many mutants for even small programs. We have experimented with different... to reduce the computational cost of the mutation testing, reducing the number of the mutants by clustering... to cluster the mutants. Thereby, re- ducing the size of mutants by selecting one ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
16 An Experimental Determination of Sufficient Mutant Operators
 

Summary:  An Experimental Determination of Sufficient Mutant Operators A. Jefferson Offutt Ammei Lee George... mutants, must be repeatedly executed. This paper quantifies the expense of mutation in terms of the number... of mutants that are created, then proposes and evaluates a technique that reduces the number of ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University; Rothermel, Gregg - Department of Computer Science and Engineering, University of Nebraska-Lincoln

 

Collection: Computer Technologies and Information Sciences

 
17 Neurobiology of Disease -Synuclein Overexpression Increases Cytosolic
 

Summary:  ., 1991). Cell lines overexpressing human WT or mutant A30P or A53T -synuclein types were generated based... . Moreover, total catechol levels were highest in cells expressing A30P or A53T mutant proteins. Cytosolic... ). ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine

 
18 MuJava : An Automated Class Mutation System Yu-Seung Ma1
 

Summary:  of mutation testing for OO programs by using two key technologies, Mutant Schemata Generation (MSG... ) and bytecode translation. This method adapts the existing MSG method for mutants that change the program... behavior and uses bytecode translation for mutants that change the program structure. A key advantage

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
19 On Guiding the Augmentation of an Automated Test Suite via Mutation Mutation testing has traditionally been used as a defect injection technique to assess the effectiveness of a test
 

Summary:  cases until the test suite is sufficient to detect as many mutants as possible and the mutation score... test cases because their mutants were immediately detected by the initial test suite, indirectly... detected by test suites we added to detect other mutants or were not able to be detected by any test. 1

  

Source: Reeves, Douglas S. - Department of Computer Science, North Carolina State University

 

Collection: Computer Technologies and Information Sciences

 
20 Neurobiology of Disease -Synuclein Overexpression in PC12 and Chromaffin Cells
 

Summary:  -syn levels relative to neurons, affects catecholamine release. Overexpression of wild-type or A30P... expression levels of WT and A30P mutant -syn. These cells possess advantages for studies of this type because... therefore ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine


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21 Copyright 2005 by the Genetics Society of America DOI: 10.1534/genetics.104.039727
 

Summary:  epithelium, (7) the lens, (8) retinal containment, and (9) behavior. The affected genes in these mutants... @fas.harvard.edu tional mutants of which 315 different affected loci have2 Present address: Department of Biology, Texas A... of the loci affected, fgr and pat, encode #12;252 J. M. ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
22 Mutant Minimization for Model-Checker Based Test-Case Generation Gordon Fraser and Franz Wotawa
 

Summary:  and then use the model-checker to search for paths that show how mutants affect output vari- ables... to be false, this suggests that the considered test-case affects the property and thus the mutant, but does... Mutant Minimization for Model-Checker Based Test-Case Generation Gordon ...

  

Source: Technische Universität Graz, Institute for Software Technology

 

Collection: Computer Technologies and Information Sciences

 
23 THE GENETICS OF CAENORHABDZTZS ELEGANS Medical Research Council Laboratory of Molecular Biology,
 

Summary:  . In general, the pulsating pharyngeal movements are not affected in the mutants, even in severely paralyzed... . In some paralyzed and semiparalyzed mutants the vulva is also affected, and eggs are not laid. Prog- eny... are described for the isolation, complementation and mapping of ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
24 How the Lac Repressor regulates the lac operon I. Defining the binding site
 

Summary:  defines binding site in vitro b. lac o mutants define the binding site in vivo II. Defining the DNA... " What does this suggest about the LacR?" #12;The lacOc mutants map to DNA protected in footprint" Rare... laci-d mutants are constitutive, and dominant! What molecular mechanism could explain this genetic

  

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

 

Collection: Biology and Medicine

 
25 INTRODUCTION Following gastrulation, vertebrate embryos can be
 

Summary:  in hindbrain organization of the single and double mutants and the associated neural crest, affected... mutants restore normal palatogenesis Case 1. Defects in the tubotympanic recess of Hoxa2 affect... interactions between these tissues. Any change that alters this ordered arrangement profoundly ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
26 461 Rapid Science Ltd ISSN 0269-9370 Introduction
 

Summary:  of intermediate mutants with positive growth rate not only strongly affects the equilibrium frequency of a n... cell count [1­5]. Monotherapy often leads to rapid emergence of drug-resistant virus mutants. For some... on whether resistant mutant virus is present before the initiation of therapy [9,10]. If ...

  

Source: Bonhoeffer, Sebastian - Institut für Integrative Biologie, Eidgenössische Technische Hochschule Zürich (ETHZ); Nowak, Martin A. - Department of Organismic and Evolutionary Biology, Harvard University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
27 Mutation Testing of Software Using a MIMD Computer A. Jefferson Offutt
 

Summary:  . A factor that affects both speedup and efficiency is the variability in the number of mutants interpreted... of which produces a set of executable variations, called mutants, of the original program. Test cases... are used to cause the mutants to gen­ erate incorrect output. Mutant ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
28 Gene Regulation! How do multicellular organisms make such radically different
 

Summary:  gene will affect the expression of all the genes controlled by the regulatory gene! Regulatory mutants... required to metabolize lactose? " 1st step= isolate mutants in lactose metabolism. How?! What phenotype... will these mutants have?! How will you distinguish them from mutants in the ...

  

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

 

Collection: Biology and Medicine

 
29 Automated screening for mutants affecting
 

Summary:  Automated screening for mutants affecting dopaminergic-neuron specification in C. elegans Maria... allele per 10 d 1 allele per 1.5 d aAs these two mutants only affect gfp expression in the two PDE... : individual mutants had distinct subsets of dopaminer- gic neurons ...

  

Source: Hobert, Oliver - Department of Biochemistry and Molecular Biophysics, Columbia University

 

Collection: Biology and Medicine

 
30 JOURNAL OF BACTERIOLOGY, 0021-9193/00/$04.00 0
 

Summary:  of transcriptional repressors. To understand how RosR affects these phenotypes, we mutagenized a rosR mutant... trait. Identification of mutants affected in competitiveness is challenging in many microbial systems... rosR in trans affected nodula- tion competitiveness in the ...

  

Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
31 INTRODUCTION Formation of the vertebrate neural plate, and generation of cell
 

Summary:  in the mid- and hindbrain. Later development of the floor plate is affected in mutant chameleon, you... ). In our screen for mutants affecting embryonic development of the zebrafish, we have recovered many... for embryonic visible mutants in the zebrafish, we found 113 mutations defining ...

  

Source: Karlstrom, Rolf O. - Department of Biology, University of Massachusetts at Amherst

 

Collection: Biology and Medicine

 
32 20/11/2007 18:16Faculty of 1000 Biology | Cooperation and conflict in quorum-sensing bacterial populations. Page 1 of 2http://www.f1000biology.com/article/id/1095043
 

Summary:  this environment favoring survival and spread of QS mutants. These findings should profoundly affect the thinking... communicate and cooperate in QS-based behaviors might be exploited by mutants that can avoid the cost... of cooperation. In this study, they showed that QS-mutant cells that either did not ...

  

Source: West, Stuart - School of Biological Sciences, University of Edinburgh

 

Collection: Environmental Sciences and Ecology

 
33 Using Compiler Optimization Techniques to Detect Equivalent Mutants
 

Summary:  Using Compiler Optimization Techniques to Detect Equivalent Mutants A. Jefferson Offutt \Lambda... differing versions, called mutants, of the same program to evaluate the quality of the data used to test... the program. Although these mutants are generated and executed efficiently by automated methods, many

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
34 Surface Mechanics Mediate Pattern Formation in the
 

Summary:  configurations? #12;Methods #1 The Roi (Rough eye) mutants! #12;Roi Genetics Roi is an allele of amos amos gene... the normal complement of photoreceptor cells #12;Applying Plateau to Mutants (Recap) Are surface... -area minimization forces working on the Roi mutants? #12;Evidence to Validate Plateau Do cone cells: Aggregate

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
35 INTRODUCTION The majority of nutritional storage in cereal grains occurs in
 

Summary:  found where the surface ridge-work typical of mutant cells affected only part of a cell's surface. Fig... . 4A,B shows an example where partially affected cells occur neighboring files of mutant cells. Fig. 4... cell fate acquisition in endosperm development. Maize dek1 mutants lack ...

  

Source: Becraft, Philip W. - Department of Genetics, Development and Cell Biology, Iowa State University

 

Collection: Biotechnology ; Biology and Medicine

 
36 DEVELOPMENTAL BIOLOGY 192, 274288 (1997) ARTICLE NO. DB978765
 

Summary:  Homozygous Mutants Are Viable and have overlapping phenotypes, the Hoxb3 mutation does Fertile weakly affect... and Hoxd3 revealed that these genes interact synergistically to affect the develop-that these mutant... seen in the Hoxa3 mutant and affected only a tants ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
37 Copyright 2000 by the Genetics Society of America Genetic Analysis of Isometric Growth Control Mechanisms in the
 

Summary:  is affected in lof mutants: To determine how often fin ray segments are initiated and (2) mecha- if the lof... mutants affect the number of seg- length of the third fin ray in sof mutants. Therefore... mech- anisms affecting G and R phases may be regulated ...

  

Source: Lehigh University, Department of Biological Sciences; Mullen, Sean P. - Department of Biological Sciences, Lehigh University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
38 nature neuroscience volume 5 no 4 april 2002 301 Amyotrophic lateral sclerosis (ALS), a progressive, fatal neurode-
 

Summary:  lacking CCS were indistinguishable from the respective SOD1- mutant mice expressing CCS. Affected mice... of CCS does not affect the onset of motor neuron disease or lifespan in G37R, G93A and G85R mutant mice... - oxide toxicity1,2. A variety of studies, including investigations of ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
39 Current Biology 19, 341345, February 24, 2009 2009 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2009.01.050 Quorum Sensing and the Social Evolution
 

Summary:  -sensing bacteria and mutants that do not respond to signal, virulence in an animal (mouse) model is reduced... relative to that of an infec- tion containing no mutants. We show that this is because mutants act... increase in frequency. This supports the idea that the invasion of QS mutants in infections of ...

  

Source: West, Stuart - School of Biological Sciences, University of Edinburgh

 

Collection: Environmental Sciences and Ecology

 
40 Synergistic interaction between Gdf1 and Nodal during anterior axis development
 

Summary:  was absent in the most severely affected Gdf1-/- ;Nodal+/- mutant embryos (Figs. 2H, I). At E9, expression... ). Although expression of Krox-20 in rhombomeres 3 and 5 appeared normal even in the most affected mutants... in the mutants (Fig. 3F). Thus, while the Gdf1-/- ;Nodal+/- mutation ...

  

Source: Ibáñez, Carlos - Department of Neuroscience, Karolinska Institutet

 

Collection: Biology and Medicine


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41 Laminin 1 and 1 Containing Laminins Are Essential for Basement Membrane Integrity in the Zebrafish Eye
 

Summary:  . Like colobomas, lens dysplasias were also bilateral in nearly all affected mutants. 2484 Lee and Gross... it was also affected in these mutants. We specifically examined Bruch's membrane regions outside of the area... in lamb1 and lamc1 mutants may therefore reflect cell fate changes ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
42 Accumulation of mutants in ``aging'' bacterial colonies is due to growth under selection,
 

Summary:  Accumulation of mutants in ``aging'' bacterial colonies is due to growth under selection... -induced mutation. In one prominent system, mutants resistant to rifampicin (RifR; rpoB; RNA polymerase) accumulate... in cell populations that ``age'' on solid medium with little net growth. Mutant accumulation was initially

  

Source: California at Davis, University of - Center for Genetics and Development, Roth Laboratory

 

Collection: Biology and Medicine ; Biotechnology

 
43 MuJava: A Mutation System for Java Yu-Seung Ma
 

Summary:  - teria, by using mutants as a method to create faults. In effect, mutation is often used as a "gold... both method-level mutants and class-level mu- tants. MuJava can be freely downloaded and installed... . Faults are introduced into the program by creating a set of faulty versions, called mutants

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
44 Removal of Pax6 Partially Rescues the Loss of Ventral Structures in Shh Null Mice
 

Summary:  . We have previously shown that dorsoventral patterning defects seen in Shh2/2 mutants are rescued... in Shh2/2 ;Gli32/2 compound mutants. Here we investigate if the loss of Pax6 can also ameliorate defects... seen in Shh2/2 mutants. In support of this notion, we observe that the fusion of the cerebral vesicles

  

Source: Fishell, Gordon - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
45 1) Molecular Biology of Plants, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
 

Summary:  pathway. Such mutants may have a mutation that more specifically affects the senescence syndrome... affect other aspects of plant growth apart from the late senescence phenotype. Thus, the old mutants were... effective, certainly in Arabidopsis (Lim et al., 2007). Mutants ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
46 Proc. Nail. Acad. Sci. USA Vol. 88, pp. 3079-3083, April 1991
 

Summary:  . Spectrophotometric titrations of the mutants showed that the amino acid at position 113 affected the p... was not affected in COS cell rhodopsin (Rho) (A) and mutant E113D (B). In mutants E113Q (C) and E113A (E... ABSTRACT Glu-113serves as the retinylidene Schiff base counterion in ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
47 Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A
 

Summary:  period (in some hosts) might affect mutant invasion when the full annual dynamics, including epidemic... Population dynamics of rapid fixation in cytotoxic T lymphocyte escape mutants of influenza A Julia... dramatic invasions of cytotoxic T lymphocyte escape mutants in human influenza A. In particular, we ...

  

Source: Grenfell, Bryan - Department of Zoology, University of Cambridge

 

Collection: Environmental Sciences and Ecology

 
48 The Plant Cell, Vol. 4, 283-295, March 1992 O 1992American Society of Plant Physiologists Evidence for Nuclear Control of the Expression of the atpA
 

Summary:  and thm24) affected in the synthe- sis of the a and/orp subunits. The phenotypeof these mutants pointed... mutants of Chlamydomonas reinhardtii altered in the expression of the chloroplast genes atpA or atp... B coding for the a or p subunit of the chloroplast ATP synthase. These mutants revealed the ...

  

Source: Wollman, Francis-André - nstitut de Biologie Physico-Chimique & Université Pierre-et-Marie-Curie, Paris 6

 

Collection: Biology and Medicine ; Renewable Energy

 
49 2461DEVELOPMENT AND STEM CELLS RESEARCH ARTICLE INTRODUCTION
 

Summary:  of Tsc1/2 mutant GSC is due to hyperactivation of TORC1. One well-studied mechanism for GSC maintenance... of marbles (bam) in GSCs. In Tsc1/2 mutant GSCs, BMP signalling activity is downregulated, but bam expression... is still repressed. Moreover, Tsc1 bam double mutant GSCs could differentiate into early cystocytes

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
50 TANMEI/EMB2757 Encodes a WD Repeat Protein Required for Embryo Development in Arabidopsis1
 

Summary:  mutant embryos differed significantly from wild type. tan Mutation Affects the Maturation Program We... -type immature seeds ger- minated. Thus, the tan mutation appears to affect dormancy, although mutant seeds were... defects in both embryo and seedling development. tan mutant embryos ...

  

Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
51 Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive
 

Summary:  . Unlike previously known root ethylene-insensitive mutants, wei2 and wei3 were not affected... used extensively for genetic screens to identify Arabidopsis mutants affected in hormone biosynthesis... or sensitivity have also been found to affect the response to ethylene (8, 11). In these ...

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collection: Biology and Medicine

 
52 An Experimental Evaluation of Selective Mutation A. Jefferson Offutt Gregg Rothermel
 

Summary:  of mutation is that many variants of the test program, called mutants, must be repeatedly executed. Selective... mutation is a way to approximate mutation test­ ing that saves execution by reducing the number of mutants... programs are mutants of the original, and a mutant is killed when a test case causes ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University; Rothermel, Gregg - Department of Computer Science and Engineering, University of Nebraska-Lincoln

 

Collection: Computer Technologies and Information Sciences

 
53 Immune and Evolutionary Approaches to Software Mutation Testing
 

Summary:  , with effectiveness measured by the number of mutant executions needed to achieve a specific mutation score. Results... the process. Mutagens Input test prog, P FalseTrue Quit TrueFalse Prog Tests Create mutants Input test cases... , T Run T on P Fix P All mutants dead? Analyse and mark equivalent mutants ...

  

Source: Timmis, Jon - Departments of Computer Science & Electronics, University of York (UK)

 

Collection: Computer Technologies and Information Sciences

 
54 The Yeast VRG4 Gene Is Required for Normal Golgi Functions and Defines a New Family of Related Genes*
 

Summary:  - way (5). The alg mutants are affected primarily in the synthe- sis of the core oligosaccharide... was in Spurr's resin. RESULTS Isolation of the vrg4 Mutant--We wished to isolate yeast mutants that affect... yeast mutants with Golgi-specific glycosylation defects to ...

  

Source: Dean, Neta - Department of Biochemistry and Cell Biology, SUNY at Stony Brook

 

Collection: Biology and Medicine

 
55 2006 Nature Publishing Group Drosophila pink1 is required for mitochondrial
 

Summary:  localizes to mitochondria, and mitochondrial cristae are frag- mented in pink1 mutants. Expression of human... of pink1 mutants, demonstrating func- tional conservation between human and Drosophila Pink1. Loss... rescues the male sterility and mitochondrial morphology defects of pink1 mutants, whereas double ...

  

Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles; Hay, Bruce A. - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
56 DEVELOPMENT 2981RESEARCH ARTICLE
 

Summary:  of five of the possible six mutant alleles were much less affected than the paralogous mutants (Fig. 4A... between adjacent paralogous mutants are highlighted in yellow). Within the overlapping affected regions... transformations in paralogous mutants are in red. ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
57 RESEARCH ARTICLE Dscam mutation leads to hydrocephalus and
 

Summary:  mutant mice prompted us to test the hypothesis that the Dscam mutation may affect the formation and... mutant brains exhibited obvious ventricular dilation, although severities and the affected regions varied... that Dscamdel17 mutant mice exhibit severe hydrocephalus, decreased motor ...

  

Source: Wu, Jane Y. - Center for Genetic Medicine & Department of Neurology, Northwestern University

 

Collection: Biology and Medicine

 
58 SHORT COMMUNICATION The N-terminal fragment of Arabidopsis photomorphogenic
 

Summary:  mutants of COP1 into cop1 null mutant backgrounds, we show that all three domains are essential... to environmental cues. Light is one of the most important factors affecting plant development, as shown... - tropic phenotype of cop1 mutants. In this paper, we examine the functional property of ...

  

Source: Deng, Xing-Wang - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine ; Biotechnology

 
59 The Relationship Between Program Dependence and Mutation Analysis Mark Harman, Sebastian Danicic,
 

Summary:  in the mutant and the original program. Those which are interesting may potentially affect the outcome... We can improve on this, however. A `killing state' must also affect the mutant at node n, otherwise... .Hierons@brunel.ac.uk Keywords: Slicing, Dependence Analysis, Test Data Generation, Equivalent ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
60 JOURNAL OF BACTERIOLOGY, Apr. 2007, p. 31983207 Vol. 189, No. 8 0021-9193/07/$08.00 0 doi:10.1128/JB.01833-06
 

Summary:  suggests that either the residues affected in class 3 mutants are not as critical as those in class 1... mutants are nonpiliated, and thus, all pilus-dependent functions are eliminated. Mutagenesis was performed... on the middle one-third of pilQ, and mutants with colony morphologies consistent with the ...

  

Source: Seifert, Hank - Department of Microbiology-Immunology, Northwestern University

 

Collection: Biology and Medicine


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61 Selective inhibitors of death in mutant huntingtin cells
 

Summary:  be valuable tools for investigating the mechanisms by which mutant htt affects caspases and induces neuronal... Selective inhibitors of death in mutant huntingtin cells Hemant Varma1, Cindy Voisine2, C Todd De... of cell death in mutant huntingtin­expressing cells. Four compounds were active in diverse HD ...

  

Source: Stockwell, Brent R. - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
62 Higher Order Mutation Testing Yue Jia and Mark Harman
 

Summary:  mutants, created by the injection of a single fault. Often these first order mutants denote trivial faults... that are easily killed. Higher order mutants are created by the insertion of two or more faults. The paper... introduces the concept of a subsuming HOM; one that is harder to kill than the first order ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
63 Plant, Cell and Environment (2006) 29, 13791387 doi: 10.1111/j.1365-3040.2006.01519.x 2006 The Authors
 

Summary:  growth, indicating that this function is dif- ferent from the functions affected in other gtr mutants... mutants affected in their response to gravity have been isolated.With the estab- lishment of a detailed... .j.cove@leeds.ac.uk Agravitropic mutants of the moss Ceratodon purpureus do ...

  

Source: Quatrano, Ralph S. - Department of Biology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
64 Selection of Antibiotic Resistance CID 2001:33 (Suppl 3) S147 S U P P L E M E N T A R T I C L E
 

Summary:  Restricting the Selection of Antibiotic-Resistant Mutants: A General Strategy Derived from Fluoroquinolone... with fluoroquinolones have led to a general method for restricting the selection of antibiotic-resistant mutants... resistance mutations for growth. That concentration has been called the "mutant prevention concentration

  

Source: Kramer, Fred - Public Health Research Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
65 AN EVALUATION OF MUTATION OPERATORS FOR EQUIVALENT MUTANTS
 

Summary:  AN EVALUATION OF MUTATION OPERATORS FOR EQUIVALENT MUTANTS By Maryam Umar Supervised By Mark Harman... Mark Harman with the proposition to work on the problem of equivalent mutants. I was told that that I... mutation operators are used to create these faulty programs. These programs are called mutants. The ...

  

Source: Harman, Mark - Department of Computer Science, King's College London; Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
66 Software-based Testing of Sequential VHDL Descriptions M. Scholiv1
 

Summary:  , called "mutants". One mutant is generated by injecting one single fault in the original program; a fault... of three main tasks: Mutant generation, Test data generation, Test evaluation. TEST DATA EVALUATION § 2... .3 TEST DATA GENERATION § 2.2 MUTANT GENERATION § 2.1 Modified Mutants ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
67 Software-based Testing of Sequential VHDL Descriptions M. Scholiv1
 

Summary:  , called "mutants". One mutant is generated by injecting one single fault in the original program; a fault... of three main tasks: Mutant generation, Test data generation, Test evaluation. TEST DATA EVALUATION § 2... .3 TEST DATA GENERATION § 2.2 MUTANT GENERATION § 2.1 Modified Mutants ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
68 Copyright 2002 by the Genetics Society of America Temperature-Sensitive Paralytic Mutants Are Enriched For Those Causing
 

Summary:  Copyright 2002 by the Genetics Society of America Temperature-Sensitive Paralytic Mutants... . The availability of a large collection of mutants exhibiting neuro- degeneration will provide a valuable resource... to elucidate these mechanisms. We have developed an effective screen for isolating neurodegeneration mutants

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
69 Automatically Detecting Equivalent Mutants and Infeasible Paths \Lambda A. Jefferson Offutt
 

Summary:  Automatically Detecting Equivalent Mutants and Infeasible Paths \Lambda A. Jefferson Offutt ISSE... is a partial solution to the problem of automatically detecting equivalent mutant programs. Equivalent mutants... equivalent mutants is a specific instance of a more general problem, commonly called the ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
70 INDUCTION AND SEGREGATION OF CHLOROPLAST MUTATIONS IN VEGETATIVE CELL CULTURES OF
 

Summary:  of forming such mutant colonies. In contrast, cells among the same cultures with reduced nuclear mutations... the pattern(s) by which an induced mutant allele is transmitted to daughter cells during vegetative division... . If there is good reason to believe that the mutant allele, or the cells containing it, are not at a ...

  

Source: Haughn, George - Department of Botany, University of British Columbia

 

Collection: Biology and Medicine

 
71 Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1
 

Summary:  -selection equilibrium, fitness interactions between mutations will affect the frequency of individual mutants within... than expected for PBMC. Epistasis affects the relative abundance of drug-resistant HIV-1 mutants... , the relative mutant frequencies are around 1028 to 1029 and ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
72 Development/Plasticity/Repair Independent Functions of SlitRobo Repulsion and Netrin
 

Summary:  ). For example, double mutants between slit and Netrin (the ligands) or robo and fra (the receptors) were... reported to result in phenotypes that were indistinguishable from single Netrin and fra mutants, leading... instead it is solely required to inhibit Netrin-mediated attraction. Analysis of multiple double-mutant

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
73 Vitamer Levels, Stress Response, Enzyme Activity, and Gene Regulation of Arabidopsis Lines Mutant in the
 

Summary:  . 4). Expression of the de novo pathway PDX1 genes also was affected in the pdx3 and sos4 mutant lines... than 2-fold in all mutants. Expres- sion of the de novo pathway gene PDX2 was not dramatically affected... as sos4 mutant plants. The growth of pdx3 mutant plants ...

  

Source: Daub, Margaret - Center for Integrated Fungal Research & Department of Plant Biology, North Carolina State University

 

Collection: Biotechnology ; Biology and Medicine

 
74 The Plant Cell, Vol. 9, 2159-2170, December 1997O 1997American Society of Plant Physiologists Disruption of.Interfascicular Fiber Differentiationinan
 

Summary:  stem elongation and fiber differentiation,a GA-insensi- tive wheat mutant affected stem height... Disruption of.Interfascicular Fiber Differentiationinan Arabidopsis Mutant RuiqinZhong,a Jennifer J. Taylor... , we isolated an interfascicular fiber mutant (ifll) by screening ethyl methanesulfonate- mutagenized

  

Source: Ye, Zheng-Hua - Department of Plant Biology, University of Georgia

 

Collection: Biology and Medicine

 
75 Using and Improving Requirement Properties for Mutation Based Test-Case Generation
 

Summary:  -based coverage measurement to allow symbolic test-case execution and determine the mutant score of any test... . Test cases are then supposed to detect the difference between original and mutant. Originally, mutation... the mutant differs, and can be transformed to test-cases. 2.2.1 Mutating the Reflected Model Ammann and Black

  

Source: Technische Universität Graz, Institute for Software Technology

 

Collection: Computer Technologies and Information Sciences

 
76 2601RESEARCH ARTICLE INTRODUCTION
 

Summary:  . Additionally, an insertional mutation affecting adss has been reported and, phenotypically, adsshi3081 mutants... ) (Johnstone et al., 1985; Long et al., 2006). Each of these de novo pathway mutants shows a subset... mutants possess defects in R-cell axon pathfinding (Long et al., 2006). Developmental roles ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
77 Mono-and double-mutant mouse models of Parkinson's disease display severe
 

Summary:  Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage... and parkin on mitochondrial integrity and function, we have generated several mono-mutant mouse lines... deletion of Parkin (Parkin-Exon3-knockout). Both mouse lines were crossed to generate the double-mutant

  

Source: Lübbert, Hermann - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
78 Copyright 0 1994 by the Genetics Society of America Altered Regulatory Responses to Glucose Are AssociatedWith a Glucose
 

Summary:  or grrlA single mutants (Figure 2). These findings suggest that GRRl affects glucose transport by a SNF3... Are AssociatedWith a Glucose Transport Defect in grl Mutants of Saccharomyces cerevisiae Laura G. Vallier... .We presenta kineticanalysisshowingthat thegrrl mutant is also defective in high affinity ...

  

Source: Vallier, Laura - Department of Biology, Hofstra University

 

Collection: Biology and Medicine

 
79 HISTIDINE MUTANTS REQUIRING ADENINE: SELECTION OF MUTANTS WITH REDUCED hisG EXPRESSION IN
 

Summary:  directly affect purine biosynthesis. This class of mutants was not analyzed further. The adenine... HISTIDINE MUTANTS REQUIRING ADENINE: SELECTION OF MUTANTS WITH REDUCED hisG EXPRESSION... of Salmonella typhimurium mutants with reduced levels of hisG enzyme activity. This method is based ...

  

Source: California at Davis, University of - Center for Genetics and Development, Roth Laboratory

 

Collection: Biology and Medicine ; Biotechnology

 
80 Molecular Biology of the Cell Vol. 8,1481-1499, August 1997
 

Summary:  Molecular Biology of the Cell Vol. 8,1481-1499, August 1997 Yeast Actin Cytoskeleton Mutants... mutants accumulate large secretory vesicles and exhibit phenotypes consistent with defects in polarized... (also known as the END4 gene), previously found to affect both the organization of the actin

  

Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University

 

Collection: Biology and Medicine


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81 Homeostasis of Synaptic Transmission in Drosophila with Genetically Altered Nerve Terminal Morphology
 

Summary:  varicosities in the mutant. Ultrastructural analysis reveals that mutant nerve terminals have bigger synapses... in synaptic complex- ity provide for more transmitter release at mutant varicosities. These results show... channels and second-messenger systems has been shown to affect arborization of NMJs in ...

  

Source: Stewart, Bryan - Department of Biology, University of Toronto at Mississauga

 

Collection: Environmental Sciences and Ecology

 
82 MILU : A Customizable, Runtime-Optimized Higher Order Mutation Testing Tool for the Full C Language
 

Summary:  a novel `test harness' technique to embed mutants and their associated test sets into a single... , called mutants, is generated by small changes to the original program p. A transformation rule that gener... - ates a mutant from the original program is known as a muta- tion operator. Mutants can be ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
83 Original Paper Dev Neurosci 2002;24:262271
 

Summary:  mutant sHW rats show cellular degeneration in the hilar region affecting specifically the pyramidal cells... as a model of neuronal degeneration. Mutant sHW rats display a number of developmental abnormali- ties... and hippocam- pal Fos protein expression in these animals indicated that mutants develop ...

  

Source: Cohen, Randy W. - Department of Biology, California State University, Northridge

 

Collection: Biology and Medicine

 
84 Introduction In recent years, many of the genes that are involved in early
 

Summary:  ossification centers at the distal ends of the radius and ulna is severely affected in mice with three mutant... studies have shown that Hoxc8, Hoxd11 and Hoxd13 can affect chondrocyte proliferation or cartilage... . For example, in mice mutant for Hoxa10, Hoxc10 and Hoxd10, or mutant for ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
85 INTRODUCTION Vertebrate Hox genes are known to play an important role in
 

Summary:  Nkx3.1 expression is affected in Hoxb13 mutants and propose that in Hoxb13 homozygous mutants... of p12 in the seminal vesicle is not affected in Hoxb13 homozygous mutants. (C) Coomassie Blue stained... -of-function mutants (Kondo et al., 1997; Podlasek et al., 1997; ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
86 KNOCK-OUT OF THE MG PROTOPORPHYRIN IX METHYLTRANSFERASE GENE IN ARABIDOPSIS: EFFECTS ON
 

Summary:  (20). We analyzed how these proteins are affected in the chlm mutant. Immunoblot analysis showed... protoporphyrin IX methyltransferase (CHLM) knock-out mutant in Arabidopsis in which the mutation induces... in the chlm mutant provides an independent indication that Mg protoporphyrin IX is a negative ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
87 Proc. Nat. Acad. Sci. USA Vol. 68, No. 9, pp. 2112-2116, September 1971
 

Summary:  three rhythm mutants isolated, having very different phenotypes, all affect the same func- tional gene... Proc. Nat. Acad. Sci. USA Vol. 68, No. 9, pp. 2112-2116, September 1971 Clock Mutants of Drosophila... ABSTRACT Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. ...

  

Source: Vosshall, Leslie - L:aboratory of Neurogenetics and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
88 RESEARCH ARTICLE Open Access Regulation of endocytic trafficking of transferrin
 

Summary:  . These results suggest that the E50K mutant affects Rab8- mediated transferrin receptor trafficking. Conclusions... by overexpression of D474N or E50K-D474N mutant suggesting that these mutants possibly do not affect the function... mutant ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
89 Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin
 

Summary:  selectiv- ity for particular cellular membranes in vivo. Two Syn point mutants (A53T and A30P... Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or -Synuclein Stephen... -wide screens were performed in yeast to identify genes that enhance the toxicity of a ...

  

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
90 Journal of Theoretical Biology 236 (2005) 335348 Spatial invasion by a mutant pathogen
 

Summary:  for that particular mutant affect the dynamics of invasion. In addition, a host can be infected by only one pathogen... is in determining how the parameters affect the ability of the mutant pathogen to invade when it arises at low... Journal of Theoretical Biology 236 (2005) 335­348 Spatial invasion by a ...

  

Source: Krone, Steve - Department of Mathematics, University of Idaho

 

Collection: Mathematics

 
91 The Effects of Amino Acid Replacements of Glycine 121 on Transmembrane Helix 3 of Rhodopsin*
 

Summary:  replacements that affect the Schiff base envi- ronment have been shown to decrease the stability of mutant... prepared a set of seven single amino acid replacement mutants of rhodopsin at posi- tion 121 (G121A, Ser... , Thr, Val, Ile, Leu, and Trp) and control mutants with replacements of Gly114 or Ala117 . ...

  

Source: Smith, Steven O.- Department of Biochemistry and Cell Biology, SUNY at Stony Brook

 

Collection: Biology and Medicine

 
92 Transformation of the Collateral Vascular Bundles into Amphivasal Vascular Bundles in an Arabidopsis Mutant1
 

Summary:  . A number of mutants affecting formation of midvein or minor veins in leaves have been isolated in grasses... so far affect vascular differentiation or leaf venation. To our knowl- edge, no mutants with a global... al., 1997). These mutants appeared not to affect the ...

  

Source: Ye, Zheng-Hua - Department of Plant Biology, University of Georgia

 

Collection: Biology and Medicine

 
93 Bioinformatics Rapid Classification of Phenotypic Mutants of
 

Summary:  provides information about the underlying processes affected in such mutants. Metabolite profiles... sex mutants are most likely to be genuinely affected in the pathway of starch breakdown. RESULTS... , known mutants affected in starch metabolism (e.g. sex4; Fig. 3) ...

  

Source: Partovi Nia, Vahid - Department of Mathematics and Statistics, McGill University

 

Collection: Mathematics

 
94 JOURNAL OF VIROLOGY, Jan. 1992, p. 505-511 0022-538X/92/010505-07$02.00/0
 

Summary:  otherwise defective mutants containing random hydrophobic sequences. However, a class of mutants... appear to display increased homodimer formation compared with mutant proteins lacking the glutamine... subjected to detailed mutational analysis. Initial studies of mutants containing amino acid substitutions

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
95 Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens
 

Summary:  phenotype is variable. Mildly affected uhrf1 mutant lenses (~50%) show anterior lens opacifications (Figs. 2... affected mutants (~50%) the lens often ruptures through the lens capsule and becomes ectopically localized... mutants have similar lens phenotypes to uhrf1 and dnmt1 single ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
96 Improved Thermostability of Bacillus circulans Cyclodextrin Glycosyltransferase by the Introduction of a
 

Summary:  with those from T. thermosulfurigenes CGTase, a B. circulans CGTase mutant (with N188D and K192R mutations... - sulfurigenes CGTase. Structural analysis of the B. circulans CGTase mutant revealed that this salt... -bridge is also formed in the mutant. Because the mutations are located in the B-domain, this result also

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
97 The Vacuolar-ATPase Complex Regulates Retinoblast Proliferation and Survival, Photoreceptor
 

Summary:  as a sixth mutant in which a v-ATPase associated protein (atp6ap1) was affected. METHODS. v-ATPase mutant... to the affected regions of the RPE. Ultrastructural analyses indicate that RPE cells in v-ATPase mutants possess... not shown). In the RPE, pigmentation levels varied between mu- ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
98 Autophosphorylation at Thr286 Calcium-Calmodulin Kinase II
 

Summary:  - tivity in the mutants but did not affect their CaM-dependent activity (14). The residual Ca... the autophosphorylation of threonine at position 286 ( Thr286 ) of this kinase without affecting its Ca... M-dependent activity. The mutant mice had no N-methyl-D-aspartate receptor­dependent LTP in the ...

  

Source: Silva, Alcino - Department of Neurobiology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
99 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 499504, January 1999
 

Summary:  Proc. Natl. Acad. Sci. USA Vol. 96, pp. 499­504, January 1999 Cell Biology A Gs mutant designed... a functionally analogous dominant negative G mutation. Here we describe a mutant subunit designed to inhibit... this mutant, we introduced into the subunit ( s) of Gs three separate mutations chosen because they impair

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
100 Function of Extracellular Loop 2 in Rhodopsin: Glutamic Acid 181 Modulates Stability and Absorption Wavelength of Metarhodopsin II
 

Summary:  -like photoproducts of the mutants, Glu181 more significantly affects the environment of the RET Schiff base in MII... a set of site-directed mutants. Sixteen of the 19 single-site mutants expressed and bound 11-cis... -retinal to form pigments. The max value of mutant pigment E181Q showed ...

  

Source: Chang, Belinda - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collection: Biology and Medicine


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