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Sample search results for: a-derived peptide inhibits

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1 Design and synthesis of peptides that bind -bungarotoxin with high Background: alpha-Bungarotoxin (alpha-BTX) is a highly toxic snake venom alpha-
 

Summary:  describe the design and synthesis of peptides that bind alpha-BTX with high affinity, and inhibit its... Design and synthesis of peptides that bind -bungarotoxin with high affinity. Abstract Background... interaction with AChR with an IC50 of 2 nM. The design of these peptides was based on a lead ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
2 NATURE MEDICINE VOLUME 6 NUMBER 1 JANUARY 2000 35 Human respiratory syncytial virus (RSV) and parainfluenza virus
 

Summary:  -treated controls (Fig. 1). The RhoA67-85 peptide did not block RSV-induced syncytium forma- A RhoA-derived peptide... on its inhibition of the interaction between RhoA and the viral fusion protein. Fig. 1 RhoA-derived... shown here the inhibition of RSV- and ...

  

Source: Crowe Jr, James E. - Department of Microbiology and Immunology, Vanderbilt University

 

Collection: Biology and Medicine

 
3 Neuropeptide precursors processing in immunocytes : Involvement in Neuroimmune communication.
 

Summary:  ). "Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP) in infectious fluids... . (2003). "Antimicrobial chromogranins and proenkephalin-A-derived peptides: Antibacterial and antifungal... activities of chromogranins and proenkephalin-A-derived ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
4 A -hairpin structure in a 13-mer peptide that binds -bungarotoxin with high-affinity and neutralizes its toxicity.
 

Summary:  A -hairpin structure in a 13-mer peptide that binds -bungarotoxin with high... junction. The structure of the complex between - bungarotoxin and a 13-mer peptide (WRYYESSLEPYPD... ) that binds the toxin with high affinity, thus inhibiting its interactions with AChR with an IC50 of 2 nM, has

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
5 Design and synthesis of peptides that bind a-bungarotoxin with high affinity and mimic the three-dimensional structure of the
 

Summary:  , synthesis and structure analysis of peptides that bind -BTX and inhibit its binding to AChR. Structurebased... Design and synthesis of peptides that bind a-bungarotoxin with high affinity and mimic the three... design concomitant with biological information of the a- BTXyAChR system yielded 13-mer peptides

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
6 The binding site of acetylcholine receptor: from synthetic peptides to solution and crystal structure.
 

Summary:  The binding site of acetylcholine receptor: from synthetic peptides to solution and crystal... structure. Abstract: Our group has been employing short synthetic peptides, encompassing sequences from... the acetylcholine receptor (AChR) -subunit for the analysis of the binding site of the AChR. A 13-mer peptide

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
7 Research Paper Design and synthesis of peptides that bind K-bungarotoxin
 

Summary:  describe the design and synthesis of peptides that bind K-BTX with high affinity, and inhibit its... ^155 www.elsevier.com/locate/chembiol #12;peptides that bind K-BTX with high a¤nity and inhibit its... and inhibits its binding to AChR with an IC50 in the low micromolar range. This ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
8 J.R. Walker Authors' afliations
 

Summary:  of novel bioactive peptides that inhibit the growth of Escherichia coli. J. Peptide Res., 2001, 58, 380... peptides that inhibit the growth of Escherichia coli Key words: bioactive; in vivo; library; peptide... to and inhibit speci®c protein ...

  

Source: California at Davis, University of - Center for Genetics and Development, Roth Laboratory

 

Collection: Biology and Medicine ; Biotechnology

 
9 Design, Synthesis, and Evaluation of Peptides with
 

Summary:  to that of the lead peptide H5, by measuring the inhibition of binding of europium-labeled estra- diol ovalbumin to m... be protected or not. The protected peptide Ac-KRWFFE-NH2 was prepared, and com- parison of the inhibition... 12 inhibited the binding slightly stronger than the ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
10 Miniaturized proteins: the backbone cyclic proteinomimetic approach. The field of proteinomimetics utilizes peptide-based molecules to mimic
 

Summary:  of proteinomimetics utilizes peptide-based molecules to mimic native protein functions. We describe a novel general... method for mimicking proteins by small cyclic peptides for the purpose of drug design, and demonstrate... its applicability on bovine pancreatic trypsin inhibitor (BPTI). These unique cyclic peptides, which

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
11 New Peptide Inhibitors of Type IB Topoisomerases: Similarities and Differences Vis-a-vis Inhibitors of
 

Summary:  combinatorial library. The most potent of these peptides also inhibit vTopo. Here, we used the same mixture... . The two most potent new peptides identified, WYCRCK and KCCRCK, inhibit plasmid relaxation, DNA cleavage... and perturbs the central base-pairing. This peptide also accumulates ...

  

Source: Segall, Anca - Department of Biology, San Diego State University

 

Collection: Biology and Medicine

 
12 pubs.acs.org/jmcPublished on Web 07/09/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 55875596 5587
 

Summary:  to mass spectrometry; LC50, peptide concentration causing 50% inhibition of Leishmania proliferation; M... -9), the short- term inhibition (IC50) of the peptides on amastigotes is more pronounced than the inhibition... - lent to those inducing a 70% inhibition of MTT ...

  

Source: Pompeu Fabra, Universitat - Departament de Ciències Experimentals i de la Salut, Proteomics and Protein Chemistry Unit

 

Collection: Biotechnology

 
13 Microbial production of thioether-stabilized
 

Summary:  Microbial production of thioether-stabilized peptides Anneke Kuipers #12;Cover: Amino acid sequence... AG Groningen. #12;RIJKSUNIVERSITEIT GRONINGEN Microbial production of thioether-stabilized peptides... peptide with non- lantibiotic peptides 21 Chapter 3 Post-translational modification of the therapeutic

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
14 The nervous system and innate immunity: the neuropeptide connection Kim A. Brogden,1
 

Summary:  ; and proenkephalin A- derived peptides (PEAP) like Peptide B76 . In addition to specific sites within the brain, PEA... . Goumon, Y. et al. Characterization of antibacterial COOH-terminal proenkephalin-A-derived peptides (PEAP... 46, 850-5 (2003). 75. Barcellini, W. ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
15 Translocation of a thioether-bridged azurin peptide fragment via the Sec pathway in Lactococcus lactis
 

Summary:  Translocation of a thioether-bridged azurin peptide fragment via the Sec pathway in Lactococcus... lactis Abstract This study demonstrates for the first time that a thioether-containing peptide, an azurin... modification enzymes. The Sec pathway can therefore be a successful alternative for those cyclized peptides

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
16 Peptides 26 (2005) 737743 Peptide Tyrosine Arginine, a potent immunomodulatory peptide
 

Summary:  analogous peptides induced neutrophil apoptosis and in the inhibition of granulopoiesis, the C... % inhibition of granulopoiesis at a concentration of 10 g/ml (Fig. 4b). At 5 g/ml the C-loop of the peptide p... as % inhibition of granulopoiesis compared to control. Increasing ...

  

Source: Richter, Stephen C. - Department of Biological Sciences, Eastern Kentucky University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
17 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 0066-4804/01/$04.00 0 DOI: 10.1128/AAC.45.9.24412449.2001
 

Summary:  Lett. 259:103­106. 10. Cavallarin, L., D. Andreu, and B. San Segundo. 1998. Cecropin A-derived peptides... prolifer- ation relative to the level of inhibition caused by the parent peptide (Fig. 2C... with peptide concentra- tion, which follows a trend similar to that for the ...

  

Source: Pompeu Fabra, Universitat - Departament de Ciències Experimentals i de la Salut, Proteomics and Protein Chemistry Unit

 

Collection: Biotechnology

 
18 A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation
 

Summary:  A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation... that are known to promote, rather than inhibit, angiogenesis. Several of these short peptides are derived from... the 5 fibrils, and hexastatins from the 6 fibrils. Some of these peptides ...

  

Source: Popel, Aleksander S. - Department of Biomedical Engineering, Johns Hopkins University

 

Collection: Engineering ; Biology and Medicine

 
19 A NEW GENERATION OF PEPTIDE-BASED INHIBITORS TARGETING HIV-1 REVERSE TRANSCRIPTASE CONFORMATIONAL FLEXIBILITY.
 

Summary:  changes associated with RT dimer-maturation (22). We have designed a peptide, Pep-A, derived from... coefficient of 260 450 M-1 .cm-1 . Peptide synthesis - Pep-A derived peptides were purchased from GL Biochem... -A was removed to improve the ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
20 Structure and Function of Integral Membrane Protein
 

Summary:  similar to that of the peptide, yielding no inhibition of the Ca-ATPase at 10-fold excess of amphiphile... with the peptide, showed neither secondary structure nor Ca-ATPase inhibition. CONCLUSION We have demonstrated... Structure and Function of Integral Membrane Protein Domains Resolved by ...

  

Source: Thomas, David D. - Departments of Biochemistry, Molecular Biology, & Biophysics, University of Minnesota

 

Collection: Biology and Medicine


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21 Holliday junction-binding peptides inhibit distinct junction-processing enzymes
 

Summary:  Holliday junction-binding peptides inhibit distinct junction-processing enzymes Kevin V. Kepple... reversible, making intermediates very difficult to study. We have identified peptides that inhibit... ). These peptides also inhibit the mechanistically related Cre, XerC ...

  

Source: Segall, Anca - Department of Biology, San Diego State University

 

Collection: Biology and Medicine

 
22 FOR THE RECORD Helicity of short E-R/K peptides
 

Summary:  FOR THE RECORD Helicity of short E-R/K peptides Ruth F. Sommese, Sivaraj Sivaramakrishnan, Robert L... July 2010 proteinscience.org Abstract: Understanding the secondary structure of peptides is important... in protein folding, enzyme function, and peptide-based drug design. Previous studies of synthetic Ala

  

Source: Spudich, James A. - Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine

 
23 CELLULAR IMMUNOLOGY 168, 193200 (1996) ARTICLE NO. 0066
 

Summary:  % inhibition of proliferation) was thethe Hu12 peptide would mirror this inactivation as the peptide... substitution, display more inhibition than peptides like VVVT, which differsSelf-Substituted Derivatives... ). Partial agonist peptides like T12 and V3, which ...

  

Source: Schountz, Tony - Department of Biological Sciences, University of Northern Colorado

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
24 Short constrained peptides that inhibit HIV-1 entry Samuel K. Sia*
 

Summary:  Short constrained peptides that inhibit HIV-1 entry Samuel K. Sia* , Peter A. Carr*, Andrea G... -1 gp41 (C-peptides) are potent inhibitors of HIV-1 entry into cells. Their mechanism of inhibition... - strained peptide (C14linkmid) inhibits cell­cell fusion at micromo- ...

  

Source: Sia, Samuel K. - Department of Biomedical Engineering, Columbia University

 

Collection: Engineering ; Biology and Medicine

 
25 Peptide Inhibitors of Dengue-Virus Entry Target a Late-Stage Fusion Intermediate
 

Summary:  the internal fold-back. One report also suggests that a stem peptide can inhibit dengue virus infection... that the same stem peptides can inhibit viral infectivity by binding the virion at neutral pH before cell... no evidence for any association (data not shown). Stem peptides ...

  

Source: Walz, Thomas - Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
26 Development of Novel Small-Size Peptides as Putative Therapeutic Drugs
 

Summary:  subsequently showed that these peptides also inhibited the conversion of angitensin I to angiotensin II (Bakhle... ). This peptide was shown to inhibit the conversion of angitensin I to II and bradykinin degradation in vitro... #12;Development of Novel Small-Size Peptides as Putative ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
27 Laminin E8 alveolarization site: heparin sensitivity, cell surface receptors, and role in cell spreading
 

Summary:  - tion with SN-peptide is heparin and EDTA inhibitable. METHODS Preparation of substrates. Mouse laminin... determin- ing cellular area. For spreading inhibition studies, SN- peptide was diluted in medium and added... inhibitable fashion. When pre- sented as a 35 uM coated substrate ...

  

Source: Laurie, Gordon W.- Department of Cell Biology, University of Virginia

 

Collection: Biology and Medicine

 
28 The Alzheimer's Disease-Associated Amyloid b-Protein Is an Antimicrobial Peptide
 

Summary:  -Ab mouse monoclonal antibody 6E10 (Figure S1). Discussion Ab peptides inhibited the growth of eight of 12... to inhibit C. albicans growth by approximately 50 percent Ab Is an Antimicrobial Peptide PLoS ONE | www... The Alzheimer's Disease-Associated Amyloid b-Protein Is an Antimicrobial ...

  

Source: Boston University, Center for Nanoscience and Nanobiotechnology

 

Collection: Materials Science

 
29 Biochem. J. (1997) 321, 107115 (Printed in Great Britain) 107 Characterization of novel calmodulin-binding peptides with distinct inhibitory
 

Summary:  peptides differentially inhibited CaM-dependent kinases I and II (CaM kinases I and INTRODUCTION Calmodulin... correspondence should be addressed. II) but did not affect CaM-dependent phosphodiesterase. Peptide 1 inhibited... CaM kinase I but not CaM kinase II, whereas peptide 2 ...

  

Source: Ikura, Mitsuhiko - Division of Molecular and Structural Biology, University of Toronto

 

Collection: Biotechnology ; Biology and Medicine

 
30 Histamine-releasing and antimicrobial peptides from the skin secretions of the Dusky Gopher frog, Rana sevosa
 

Summary:  secretions of Rana sevosa Peptide name Zone of inhibition on E. coli seeded plates (mm2 ) Zone of inhibition... Histamine-releasing and antimicrobial peptides from the skin secretions of the Dusky Gopher frog... of invertebrates and vertebrates is the production of antimicrobial peptides, ...

  

Source: Richter, Stephen C. - Department of Biological Sciences, Eastern Kentucky University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
31 nature immunology volume 10 number 11 november 2009 1143 Pulendran, B. Nat. Immunol. 8, 10861094 (2007).
 

Summary:  selecting peptides: their job does not end in the thymus Kai W Wucherpfennig & Etienne Gagnon Peptides able... peptides for CD4+ T cells. Kai w. wucherpfennig is in the Department of Cancer Immunology and AIDS, Dana... peptides responsible for posi- tively selecting major histocompatibility complex (MHC) ...

  

Source: Wucherpfennig, Kai W. - Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard University

 

Collection: Biology and Medicine

 
32 Proc. Nati. Acad. Sci. USA Vol. 83, pp. 1613-1616, March 1986
 

Summary:  peptide was assayed for its ability to inhibit the phosphorylation of the synthetic peptide Leu... - vidual peptides. A rough indication ofthe Ki was obtained by determination of the IC50 for inhibition... of the smaller peptide, did not affect the ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
33 Post-translational modification of the therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin
 

Summary:  Post-translational modification of the therapeutic peptides by NisB, the dehydratase... in the activity and receptor specificity of biologically active peptides. In addition, a dehydroamino acid can... be coupled to a cysteine to yield a cyclized peptide with increased biostability and resistance against

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
34 Published Ahead of Print 22 February 2010. 10.1128/AAC.01610-09.
 

Summary:  Salmonella InhibitsIn VitroRepair Intermediates An Antimicrobial Peptide That Targets DNA http... Peptide That Targets DNA Repair Intermediates In Vitro Inhibits Salmonella Growth within Murine... -mediated recombination by trapping and preventing resolution of the Holliday junction intermediate. This ...

  

Source: Segall, Anca - Department of Biology, San Diego State University

 

Collection: Biology and Medicine

 
35 JOURNAL OF VIROLOGY, June 2004, p. 66576665 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.66576665.2004
 

Summary:  , the optimized peptide inhibits KSHV Pr activity by 50% at a 200-fold molar excess of peptide to KSHV Pr... dimerization and thereby inhibit the activity of the protease. The peptide inhibitor was rationally designed... -acid peptide was designed to disrupt ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
36 Journal of Cellular Biochemistry 104:13561363 (2008) Novel Anti-Angiogenic Peptides Derived From
 

Summary:  of the identified peptides to inhibit the basic components of angiogenesis even though they are derived from pro... is only required is in the case of chemokinostatin-3. The Short Peptides Inhibit the Proliferation... of HUVECs In Vitro We first tested the ability of the six short ...

  

Source: Popel, Aleksander S. - Department of Biomedical Engineering, Johns Hopkins University

 

Collection: Engineering ; Biology and Medicine

 
37 Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin Michael D. Scholle a
 

Summary:  that the peptide selectively inhibits the interaction of gp522 with Trx, under oxidizing conditions, with an IC50... The activity of Trx and inhibition in the presence of peptides were measured as described by Holmgren... inhibition: Trx peptide ligand TP-2 (NH2- ...

  

Source: Richardson, Charles C. - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
38 Conclusions and Perspectives Conclusions.
 

Summary:  of peptide and protein folding. It was found that the interactions that determine protein folding mainly... by factors such as changing the solvent environment or the termini of the peptide or protein, to either... promote or destabilize peptide folding. Thus the precise structure adopted by a protein in vitro

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
39 The inability of lactic acid bacteria to synthesize a large number of amino acids necessitates the presence of a proteolytic system in those environments where protein is the
 

Summary:  in which the peptides or peptide analogues compete for uptake with Pro-[14 C]Ala. Inhibition of Pro- [14 C... in three compartments: an extracellularly located proteinase, three membrane-bound peptide transporters... and utilization of peptides in L.lactis. The sequence of events in the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
40 Reversible Inhibitors of Integrase-mediated Recombination Efficiently Trap Holliday Junction Intermediates and Form the
 

Summary:  taken advantage of reversible inhibition by the active peptides to develop a new assay for Holliday... junctions in the excision pathway as well as in the other path- ways. Like peptide KWWCRW, they also inhibit... . At 28 M peptide, excision is completely inhibited ...

  

Source: Segall, Anca - Department of Biology, San Diego State University

 

Collection: Biology and Medicine


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41 SwePep, a Database Designed for Endogenous Peptides and Mass Spectrometry*
 

Summary:  ) and to inhibit angiotensin-converting enzyme activity (29). Searching for Peptide Identities Using Swe... , which impair the possibility to identify these peptides because the disulfide bonds may inhibit... SwePep, a Database Designed for Endogenous Peptides and Mass Spectrometry* Maria ...

  

Source: Chait, Brian T. - Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University

 

Collection: Biology and Medicine

 
42 Cell, Vol. 97, 471480, May 14, 1999, Copyright 1999 by Cell Press Structure of the Enabled/VASP Homology 1
 

Summary:  . The Mena EVH1 domain (residues 1­112) was cocrystal- lized with the ActA-derived peptide Ac-FPPPPT-CONH2... residues outside the EVH1 aromatic triad. ActA-derived peptides, C-terminal to the core are underlined... length ActA-derived peptides utilized in ...

  

Source: Lim, Wendell - Departments of Cellular and Molecular Pharmacology & Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
43 Synthetic peptides in the diagnosis of human echinococcosis
 

Summary:  pattern were excised from SDS-gels. One band (band A) derived from a 15% gel, two bands from a 5... Synthetic peptides in the diagnosis of human echinococcosis Inauguraldissertation zur Erlangung der... of diagnostic antigen by peptide microarray 23 Chapter 2: Mass spectrometry based design of synthetic ...

  

Source: Amrhein, Valentin - Zoologisches Institut, Universität Basel

 

Collection: Environmental Sciences and Ecology

 
44 Design strategies for anti-amyloid agents Jody M Mason
 

Summary:  of the amyloidogenic peptide from its parent protein using protease inhibitors. 3. Inhibiting aggregation... of the protein or peptide directly using small ligands or indirectly by vaccination. 4. Inhibiting other effects... effective treatments may be those designed to inhibit steps ...

  

Source: Mason, Jody - Department of Biological Sciences, University of Essex

 

Collection: Biotechnology ; Biology and Medicine

 
45 ALZHEIMER'S AMYLOID-BETA PEPTIDE INHIBITS SODIUM/CALCIUM EXCHANGE MEASURED IN RAT AND
 

Summary:  ALZHEIMER'S AMYLOID-BETA PEPTIDE INHIBITS SODIUM/CALCIUM EXCHANGE MEASURED IN RAT AND HUMAN BRAIN... M is the inhibition curve shown in Fig. 3. It is noteworthy that freshly-prepared peptide or ``aged'' A scrambled... from a single experiment. Amyloid- peptide ...

  

Source: Colvin, Robert A.- Department of Biological Sciences, Ohio University

 

Collection: Biology and Medicine

 
46 A synthetic peptide with estrogen-like activity derived from a phage-display peptide library
 

Summary:  . H5 and the elongated cyclic peptide, each at a concentration of 0.5 mM, inhibited 36% of the binding... peptide Pep. H5 and the elongated cyclic peptide bind to mAb E2­15 specifically and inhibit binding of [3... cyclic peptide bind to ER and not ER , and ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
47 Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium Veprintsev, Moshe Kotler, Amnon Hizi, Abraham Loyter, and Assaf Friedler
 

Summary:  approach for the inhibition of the HIV-1 integrase (IN) protein by using peptides derived from its cellular... . The peptides inhibit the DNA-bind- ing of IN by shifting the IN oligomerization equilibrium from the active... processing. The LEDGF/ p75-derived peptides ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
48 Summary and general conclusions Chapter six
 

Summary:  peptides exhibit enzyme-inhibiting or immunosuppressive activities. The biosynthesis of these peptides... is the production of compounds to facilitate the uptake of essential metal ions and to inhibit competing organisms... . Often these compounds are of peptide origin, synthesized either ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
49 Effects of myoinhibitory peptides on food intake in the German cockroach
 

Summary:  peptide, inhibiting food intake by 60­80% at doses between 15 and 50 mg, followed by Grb-AST-B1 (45... that a number of peptides effectively inhibit food intake in this cockroach. These peptides include... , the peptides Grb-AST-B1 and B3 inhibit ...

  

Source: Belles, Xavier - Institut de Biologia Evolutiva, Universitat Pompeu Fabra

 

Collection: Biology and Medicine

 
50 Published: September 12, 2011 r 2011 American Chemical Society 2143 dx.doi.org/10.1021/bc200415v |Bioconjugate Chem. 2011, 22, 21432153
 

Summary:  |Bioconjugate Chem. 2011, 22, 2143­2153 ARTICLE pubs.acs.org/bc Hydrazide Reactive Peptide Tags for Site... strategies. One route, enzymatic labeling of genetically encoded peptide substrates, is useful in forming... - ique peptide sequences capable of forming covalent bonds with chemical probes. The latter approach does

  

Source: Weiss, Gregory A. - Department of Chemistry, University of California, Irvine

 

Collection: Chemistry

 
51 Neuropeptide-derived antimicrobial peptides from invertebrates for biomedical applications
 

Summary:  -25]. Bactericidal activities of the chromogranin- or pro-enkephalin-A-derived peptides are modulated by the degree... -25]. These peptides inhibit the growth of Gram-positive bacteria (Micrococcus luteus and Bacillus megaterium... 1 Neuropeptide-derived antimicrobial peptides from ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
52 Characterisation of antibacterial activity of peptides isolated from the venom of the spider
 

Summary:  by a liquid growth inhibition assay. All ®ve peptides showed minimal inhibitory concentrations... of growth inhibition were recorded after an overnight incubation at 378C. The puri®ed peptides were... Characterisation of antibacterial activity of peptides isolated from the venom of the ...

  

Source: Richner, Heinz - Zoologischen Institut, Universität Bern

 

Collection: Environmental Sciences and Ecology

 
53 Brent Berwin, Justin P.Hart, Stuart Rice1 Cecilia Gass1
 

Summary:  recognition and internalization. gp96 internalization and peptide re- presentation are inhibited by the SR... for their ability to internalize chaperone proteins. SR-A±/± derived macro- Fig. 2. Endotoxin stimulation of RAW264... determined whether fucoidin would inhibit gp96-depend- ...

  

Source: Hogan, Brigid L.M. - Department of Cell Biology, Duke University; Richardson, David - Department of Biochemistry, Duke University

 

Collection: Biology and Medicine ; Biotechnology

 
54 Peptide Inhibitors of DNA Cleavage by Tyrosine Recombinases and Topoisomerases
 

Summary:  -substrate complex, insofar as inhibition is resistant to high levels of non-speci®c competitor DNA and the peptides... , but have no apparent effect on DNA religation by preformed covalent complexes. The peptides also inhibit... Escherichia coli topoisomerase I, a type IA enzyme. Finally, the ...

  

Source: Segall, Anca - Department of Biology, San Diego State University

 

Collection: Biology and Medicine

 
55 Membrane disruption ability of facially amphiphilic helical peptides Yvonne R. Vandenburg,a Bradley D. Smith,*a Eric Bironb and Normand Voyer*b
 

Summary:  Membrane disruption ability of facially amphiphilic helical peptides Yvonne R. Vandenburg,a Bradley... Article on the web 8th July 2002 A helical 14-residue peptide containing four polar, but uncharged, benzo... - gous 21-mer or 7-mer peptides. Antimicrobial peptides are currently under active investigation

  

Source: Smith, Bradley D. - Department of Chemistry and Biochemistry, University of Notre Dame

 

Collection: Chemistry

 
56 Identication of peptide inhibitors of pre-mRNA splicing derived from the essential interaction
 

Summary:  proteins. Certain peptides derived from the binding domains of both proteins were found to inhibit in vitro... splicing. This splicing inhibition could be prevented by preincubating the peptides with the corresponding... to the manufacturer's instructions. RESULTS Inhibition of pre-mRNA ...

  

Source: Lamond, Angus I. - Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee

 

Collection: Biology and Medicine

 
57 Amphibian antimicrobial peptides and Protozoa: Lessons from parasites Luis Rivas a,
 

Summary:  Sequence Protozoan specie (stage)b Microbicidal effect Comments References Inhibition (%) [Peptide] (M... Comments References Inhibition (%) [Peptide] (M) MSI-94 GIGKFLKKAKKFGKAFVKMKK-NH2 T. cruzi (epi) 50 100... Review Amphibian antimicrobial peptides and Protozoa: Lessons from parasites ...

  

Source: Pompeu Fabra, Universitat - Departament de Ciències Experimentals i de la Salut, Proteomics and Protein Chemistry Unit

 

Collection: Biotechnology

 
58 THEJOURNALOF BIOLOGICALCHEMISTRY 0 1993 by The American Societyfor Biochemistry and MolecularBiology,Inc
 

Summary:  - comas, C32amelanoticmelanomas,andendothelial cells. These peptides also inhibit the adhesionof cells... peptides are inter- changeable in inhibiting the adhesionof G361 cells to LM or TS1, suggestinga possible... cell attachment,and soluble peptides added to the medium ...

  

Source: Frazier, William A. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
59 JOURNAL OF BACTERIOLOGY, 0021-9193/01/$04.00 0 DOI: 10.1128/JB.183.2.716724.2001
 

Summary:  oxidoreductases that convert transaminated amino acids into their corresponding coenzyme A (CoA) derivatives (Fig... . 2) (3, 15, 31, 32). These CoA derivatives, together with acetyl- CoA produced from glycolysis via... for Sulfur in Peptide Metabolism and in Regulation of Three ...

  

Source: Holden, James F. - Department of Microbiology, University of Massachusetts at Amherst

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
60 The Synergy Peptide PHSRN and the Adhesion Peptide RGD Mediate Cell Adhesion through a Common Mechanism
 

Summary:  could be inhibited completely by a soluble RGD peptide and partially by a soluble PHSRN peptide. IMR 90... or 10th domain of FN could be inhibited by either of the two soluble peptides, RGD or PHSRN (22... either RGD or the PHSRN peptide and that 3T3 fibroblast ...

  

Source: Mrksich, Milan - Department of Chemistry, University of Chicago

 

Collection: Chemistry


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61 JOURNAL OF VIROLOGY, Dec. 2010, p. 1254912554 Vol. 84, No. 24 0022-538X/10/$12.00 doi:10.1128/JVI.01440-10
 

Summary:  2010 Peptides derived from the "stem" of dengue virus (DV) type 2 (DV2) envelope (E) protein inhibit DV... DV serotypes cross-inhibit DV1 to DV4 but that corresponding peptides derived from related... a two-step model of how stem-derived peptides inhibit viral entry. ...

  

Source: Walz, Thomas - Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
62 Release of Signal Peptide Fragments into the Cytosol Requires Cleavage in the Transmembrane Region by a Protease Activity That
 

Summary:  shown). Similarly, signal peptide processing was inhibited by calpain inhibitor I, another cysteine... . Because synthetic FIG. 3. (Z-LL)2 ketone inhibits processing of the p-Prl signal peptide. A, cleavage... nM inhibitor. FIG. 4. Inhibition of processing prevents release of the signal ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
63 Allosteric Inhibition of the Epithelial Na Channel through Peptide Binding at Peripheral Finger and Thumb Domains*S
 

Summary:  Allosteric Inhibition of the Epithelial Na Channel through Peptide Binding at Peripheral Finger... of inhibitory tracts. Peptides derived from these tracts inhibit channel activity. The mechanism by which... the effect of these muta- tions on peptide-dependent channel ...

  

Source: Grabe, Michael - Department of Biological Sciences, University of Pittsburgh

 

Collection: Biology and Medicine

 
64 Miniaturized Proteins: The Backbone Cyclic Proteinomimetic Approach
 

Summary:  - ble peptide bond (Lys15-Ala16), and inhibits tryp- sin by forming a tight complex with it (Bode... -proteinomimetic (step (IV) above) was carried out by measuring the inhibition of trypsin by the BC peptides using Na... . The different inhibition potencies obtained for the BC ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research

 

Collection: Environmental Sciences and Ecology ; Environmental Management and Restoration Technologies

 
65 Identification of novel short peptides derived from the a4, a5, and a6 fibrils of type IV collagen with anti-angiogenic properties
 

Summary:  controls. The short peptides inhibit the proliferation of HUVECs We first tested the ability of each... assessed the anti-angiogenic effect of the eight peptides by measuring their ability to inhibit... inhibition relative to the used controls (Fig. 2). Of the eight tested ...

  

Source: Popel, Aleksander S. - Department of Biomedical Engineering, Johns Hopkins University

 

Collection: Engineering ; Biology and Medicine

 
66 Chemistry & Biology The Platelet Integrin aIIbb3 Binds
 

Summary:  present- ing either peptide. Cell adhesion could be inhibited by either soluble peptide, demonstrating... -derived peptide LGGAKQAGDV also inhibited Fbg binding to platelets with an affinity comparable to that of RGDS... inhibit the binding of A2A9 to platelets. These ...

  

Source: Mrksich, Milan - Department of Chemistry, University of Chicago

 

Collection: Chemistry

 
67 Molecules 2011, 16, 3499-3518; doi:10.3390/molecules16053499 ISSN 1420-3049
 

Summary:  peptides. These peptides may prevent viral attachment to host cell receptors or inhibit the replication... been used for the selection of random peptides by phage display that (1) specifically inhibit cell... of a nonapeptide giving rise to 16 variants with the potential to ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
68 Polyps, peptides and patterning Thomas C.G. Bosch1
 

Summary:  Polyps, peptides and patterning Thomas C.G. Bosch1 * and Toshitaka Fujisawa2 Summary Peptides serve... approach (The Hydra Peptide Project ) has revealed that Hydra contains several hun- dreds of peptide... . These peptides control biological processes as diverse as muscle contraction, ...

  

Source: Bosch, Thomas C. G. - Zoologisches Institut Am Botanischen Garten, Christian-Albrechts-Universität zu Kiel

 

Collection: Biology and Medicine

 
69 Peptide arrays: towards routine implementation Dal-Hee Min and Milan Mrksich
 

Summary:  that inhibits broad classes of b-lactamases with activities in the 100 mM range. In an example that used peptide... Peptide arrays: towards routine implementation Dal-Hee Min and Milan Mrksichà Peptide arrays have... and enzyme activities are directed towards peptides, the preparation of ...

  

Source: Mrksich, Milan - Department of Chemistry, University of Chicago

 

Collection: Chemistry

 
70 Biophysical Chemistry 100 (2003) 293305 0301-4622/03/$ -see front matter 2002 Elsevier Science B.V. All rights reserved.
 

Summary:  and identified a library lead-peptide (MRYYESSLKSYPD) that specifically binds a- BTX and inhibits its binding... and prepare peptides that bind a-BTX with high affinity and inhibit its interaction with AChR, by taking... in intra-peptide interaction. The inhibition ...

  

Source: Kasher, Roni - Zuckerberg Institute for Water Research, Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research; Sussman, Joel L. - Department of Structural Biology, Weizmann Institute of Science

 

Collection: Biology and Medicine ; Environmental Management and Restoration Technologies ; Environmental Sciences and Ecology

 
71 John von Neumann Institute for Computing Inhibition of Fibril Formation of
 

Summary:  John von Neumann Institute for Computing Inhibition of Fibril Formation of Beta-Amyloid Peptides N... inhibits amyloid formation. An another powerful strategy for inhibition is a peptide N... of the whole system. 123 #12;In conclusion, we have shown that a short ...

  

Source: Kouza, Maksim - Institute of Physics, Polish Academy of Sciences

 

Collection: Biology and Medicine ; Physics

 
72 Molecules 2011, 16, 774-789; doi:10.3390/molecules16010774 ISSN 1420-3049
 

Summary:  for the biotin-binding site. Moreover, synthetic 7-mer peptides having the HPQ motif were not able to inhibit... to the ring carbons. The strongest binding peptide, MYWYPY, inhibited the binding of methyl -D... of the altered binding kinetics of the peptide [8]. In later studies this ...

  

Source: Orner, Brendan Patrick - Division of Chemistry and Biological Chemistry, Nanyang Technological University

 

Collection: Biology and Medicine ; Chemistry

 
73 The International Journal of Biochemistry & Cell Biology 39 (2007) 23142323 Peptides derived from type I thrombospondin repeat-containing
 

Summary:  evidence that the complestatin-C6 peptide shows anti-angiogenic activity, inhibiting the proliferation... and migration of HUVECs. 3.1. The tested peptides inhibit the proliferation of HUVECs in vitro Evidence... . Therefore, we have tested the ability of the short peptides to ...

  

Source: Popel, Aleksander S. - Department of Biomedical Engineering, Johns Hopkins University

 

Collection: Engineering ; Biology and Medicine

 
74 Mechanistic dissection of the enzyme complexes involved in the biosynthesis of lacticin 3147 and nisin
 

Summary:  Lactococcus lactis species and inhibit a broad range of Gram-positive bacteria. Lantibiotics are peptide... that the combination of LtnM2 and LtnT can modify, process and transport peptides entirely different from LtnA2... and that LtnT can process and transport unmodified LtnA2 and unrelated peptides. ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
75 The midgut is an important site for both nutrient absorption and ionic regulation in lepidopteran larvae (Dow, 1986). The
 

Summary:  ;3069Peptide inhibition of midgut ion transport (CA) juvenile hormone (JH) biosynthesis by this peptide... peptides, F7G and F7D (100 nmol l-1), to the hemolymph side of the tissue also rapidly inhibited the Isc... (Fig. 2A,B), but the inhibition of Isc by these two ...

  

Source: Chamberlin, Mary - Department of Biological Sciences, Ohio University

 

Collection: Biology and Medicine

 
76 Sec-mediated transport of post-translationally dehydrated peptides in Lactococcus lactis
 

Summary:  Sec-mediated transport of post-translationally dehydrated peptides in Lactococcus lactis Abstract... Nisin is a lanthionine-containing antimicrobial peptide produced by Lactococcus lactis. Its (methyl... a wide range of non-lantibiotic peptides. Here we demonstrate that in the absence of NisT and Nis

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
77 Reconstruction of the Proteolytic Pathway for Utilization of -Casein by Lactococcus lactis
 

Summary:  proteinase (PrtP), the uptake of part of the peptides by the oligopeptide transport system (Opp... ), and the degradation of accumulated peptides by a multitude of intracellular peptidases. We investigated... . The PrtP-generated peptides were identified by on-line coupling of liquid chromatography to mass

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
78 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 45834588, May 1996
 

Summary:  Proc. Natl. Acad. Sci. USA Vol. 93, pp. 4583­4588, May 1996 Immunology Antigenic peptides... Avenue, Cambridge, MA 02138 Contributed by Don C. Wiley, January 4, 1996 ABSTRACT Recognition of peptides... novo cyclic peptides that incorporate PEG in the ring structure for binding to class I MHC molecules

  

Source: Harrison, Stephen C. - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Chemistry ; Biology and Medicine

 
79 Oligomeric b-Structure of the Membrane-Bound HIV-1 Fusion Peptide Formed from Soluble Monomers
 

Summary:  Oligomeric b-Structure of the Membrane-Bound HIV-1 Fusion Peptide Formed from Soluble Monomers Jun... The human immunodeficiency virus type 1 (HIV-1) fusion peptide serves as a useful model system... have shown that the peptide adopts an oligomeric b-strand structure when associated with a lipid

  

Source: Weliky, David - Department of Chemistry, Michigan State University

 

Collection: Chemistry

 
80 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 87028707, August 1997
 

Summary:  somewhat inhibit peptide dissocation from MHC, as discussed in detail by Beeson et al. (17)]. Thus, in both... recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex JOSHUA D... Helper T cells are triggered by molecular com- plexes of antigenic peptides and ...

  

Source: Rabinowitz, Joshua D. - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University

 

Collection: Biology and Medicine ; Biotechnology


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81 Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High-Throughput Screening: The
 

Summary:  Broad-Spectrum Antimicrobial Peptides by Rational Combinatorial Design and High... November 28, 2008; E-mail: wwimley@tulane.edu Abstract: We recently described 10 peptides selected from... in vitro.8 These peptides did not share a common sequence motif, length, or net charge; nonetheless

  

Source: Wimley, William C. - Department of Biochemistry, Tulane University

 

Collection: Biology and Medicine

 
82 r XXXX American Chemical Society A dx.doi.org/10.1021/bi200696s |Biochemistry XXXX, XXX, 000000 pubs.acs.org/biochemistry
 

Summary:  (Figure 8). Increased membrane activity of these peptides could arise from inhibited intramem- brane loop... Fusion Peptide Oscar Torres and Dennis Bong* Department of Chemistry, The Ohio State University, Columbus... in the HIV fusion peptide sequence. HIV mem- brane fusion1,2 is mediated by the surface ...

  

Source: Bong, Dennis - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
83 Structural and Dynamical Analysis of the Hydration of the Alzheimer's -Amyloid Peptide
 

Summary:  but different from that of the bulk, (2) the peptide structure inhibits diffusion perpendicular to the peptide... Structural and Dynamical Analysis of the Hydration of the Alzheimer's -Amyloid Peptide FRANCESCA... solvation shell obtained from the molecular dynamics simulation of the amyloid (10-35)NH2 ...

  

Source: Straub, John E. - Department of Chemistry, Boston University

 

Collection: Chemistry

 
84 Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential
 

Summary:  peptides, with potential therapeutic application. Cationic, facially amphipathic helical -peptide oligomers... proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in -peptides... region Introduction Peptides are short, sequence- and length-specific oligomers composed of ...

  

Source: Barron, Annelise E. - Department of Bioengineering, Stanford University

 

Collection: Materials Science ; Biotechnology

 
85 amino acid sequence gastrin I 2 126 pGlu-Arg-(Pro)2
 

Summary:  Peptide Mr amino acid sequence gastrin I 2 126 pGlu-Arg-(Pro)2 -Met-(Glu)5 -Ala- Tyr... -Thr-Ser-Cys (disulfide bridge 3-14) hormone release inhibiting factor) pentaglycine 303 Gly-Gly-Gly-Gly-Gly h... - Thr-Leu-(Glu)2 -(Met)2 -Thr-Ala-Cys-Gln-Gly- Val-Gly On the Purification of Peptides with Size

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
86 Peptide transport in microorganisms Specificity and selectivity determinants of peptide
 

Summary:  is to measure competitive inhibition of a reporter peptide, as has been done for the Opp system (Detmers et al... -binding protein OppA, inhibits transport of the reporter peptide Leu-enkephaline (YGGFL) but, as indicated... inhibited by the addition of 100 µM bradykinin (RPPGFSPFR), a ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
87 Peptides Derived from Type IV Collagen, CXC Chemokines,
 

Summary:  GPWGPCSVTCSKGTQIRQR 1286 Endogenous Peptides Inhibit Breast Cancer Growth Koskimaki et al. Neoplasia Vol. 11, No. 12... , 2009 Endogenous Peptides Inhibit Breast Cancer Growth Koskimaki et al. 1287 #12;growth suppression... administration. 1288 Endogenous Peptides ...

  

Source: Popel, Aleksander S. - Department of Biomedical Engineering, Johns Hopkins University

 

Collection: Engineering ; Biology and Medicine

 
88 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 0099-2240/99/$04.00 0
 

Summary:  system containing rabbit reticulocyte lysate, synthetic peptide C430 did not inhibit protein synthesis... -displayed peptide. However, binding of antisera to immobilized phage-displayed peptide was not inhibited by free DON... to DON-induced protein synthesis ...

  

Source: Kuhn, Leslie A.- Department of Biochemistry and Molecular Biology, Michigan State University

 

Collection: Biology and Medicine

 
89 Abstract The myristoylated alanine-rich C kinase sub-strate (MARCKS) and the MARCKS-related protein
 

Summary:  -mediated phosphorylation cascades. We have studied Ca2+ binding of CaM com- plexed with CaM binding peptides from MARCKS... peptides induced significant increases in the Ca2+ affinity of CaM (pCa 6.1 and 5.8, respectively, compared... to 5.2, for CaM in the absence of bound peptides), whereas a mod- ified MARCKS ...

  

Source: Ikura, Mitsuhiko - Division of Molecular and Structural Biology, University of Toronto

 

Collection: Biotechnology ; Biology and Medicine

 
90 Peptide self-assembly as a model of proteins in the pre-genomic world
 

Summary:  to overcome product inhibition was to incorporate a proline kink at the centre of a self-replicat- ing peptide... , is similar for both KK35 and TA, thus pointing to significant product inhibition. A peptide/RNA replicating... Peptide self-assembly as a model of proteins in the pre-genomic ...

  

Source: Ghosh, Indraneel - Department of Chemistry and Biochemistry, University of Arizona

 

Collection: Chemistry

 
91 Effects of Chytrid and Carbaryl Exposure on Survival, Growth and
 

Summary:  (14-17). Finally, we examined the ability of R. boylii skin peptides to inhibit growth of chytrid... in purified form for growth inhibition of chytrid zoospores. In addition to the purified peptides, we tested... to affect the ability of peptides to inhibit chytrid ...

  

Source: Shaffer, H. Bradley - Section of Evolution and Ecology, University of California, Davis

 

Collection: Environmental Sciences and Ecology

 
92 Robust production of a peptide library using methodological synchronization Kristen L. Huber, Kevin D. Olson, Jeanne A. Hardy *
 

Summary:  . This limited library was designed as aPP mimics of natural prote- ase-inhibiting peptides. Mutations included... Robust production of a peptide library using methodological synchronization Kristen L. Huber, Kevin... May 2009 Available online 18 May 2009 Keywords: Peptide library Fusion partner Avian ...

  

Source: Hardy, Jeanne - Department of Chemistry, University of Massachusetts at Amherst

 

Collection: Chemistry

 
93 Developmental & Comparative
 

Summary:  of peptides and individual purified peptides strongly inhibit chytrid growth. The concentration of total... without peptide. To determine the value for maximal inhibition (negative control for growth) some cultures... -ami- dated residue [26]. 3.4. Antichytrid growth ...

  

Source: Vredenburg, Vance Thomas - Department of Biology, San Francisco State University

 

Collection: Biology and Medicine

 
94 Surfactant Effects on Amyloid Aggregation Kinetics Ran Friedman 1, 2
 

Summary:  surfactants and fibril-forming peptides are still not clear. Here, coarse-grained simulations are employed... to study the aggregation kinetics of amyloidogenic peptides in the presence of amphiphilic lipids... . The simulations show that the lower the fibril formation propensity of the peptides, the higher the influence

  

Source: Caflisch, Amedeo - Department of Biochemistry, Universität Zürich

 

Collection: Biology and Medicine

 
95 Evolution of malaria parasite plastid targeting sequences
 

Summary:  for function. Many hundreds of plastid-derived genes must have acquired transit peptides for successful... relocation to the nucleus. Here, we explore potential evolutionary origins of plastid transit peptides... as transit peptides after exon shuffling. We further demonstrate that numerous randomized ...

  

Source: McFadden, Geoff - School of Botany, University of Melbourne

 

Collection: Environmental Sciences and Ecology

 
96 T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for
 

Summary:  of cognate peptide and major histocompatibility complex (pMHC) per DC and with the density of antigen... (TCRs), each with a discrete affinity for a given complex of cognate peptide and major... of fluorescence-labeled DCs pulsed with a model peptide antigen and the Toll-like receptor 4 ligand

  

Source: von Andrian, Ulrich H. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
97 0022-1554/88/$3.30 The Journal of Histoehemistry and Cytochemistry
 

Summary:  . The reactions of somanosnatin pepnide an- tisena with bound immunizing peptide were inhibited only afte5... , did non inhibit reac- nion ofsomanosnanin peptide antisera with bound immunizing pep- tide (not shown... KLH-CGGSANSNPAMAPRE binding in brain was completely inhibited by ...

  

Source: Columbia University - Jerome L. and Dawn Greene Infectious Disease Laboratory

 

Collection: Biology and Medicine

 
98 Virus Research 120 (2006) 146155 Inhibition of severe acute respiratory syndrome-associated coronavirus
 

Summary:  ­70% at concentrations of 15­30 M. Interestingly, peptides analogous to the SARS-CoV or MHV loop region inhibited viral... ). This peptide has been shown to potently inhibit HIV-1 virion:cell fusion at very low concentrations (50... that HR1 and/or HR2 peptides could likewise ...

  

Source: Wimley, William C. - Department of Biochemistry, Tulane University

 

Collection: Biology and Medicine

 
99 Neuroprotective action & neutralization of a42 memory impairment by a novel in silico designed n-methyl
 

Summary:  . In the present study, we report the in silico design of a new A-derived synthetic penta-peptide Ac... designed to inhibit steps that precede A peptide aggregation, by blocking the production of toxic soluble... designed n-methyl amino acids containing peptide Marcelo F. Masman, Ivica ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
100 Journal of Peptide Science J. Pept. Sci. 2008; 14: 383388
 

Summary:  Journal of Peptide Science J. Pept. Sci. 2008; 14: 383­388 Published online 11 December 2007... in Wiley InterScience (www.interscience.wiley.com). DOI: 10.1002/psc.980 Membrane-bound peptides from V... -ATPase a potential drug target. Short synthetic peptides that are presented here mimic the 7th transmembrane domain

  

Source: Hemminga, Marcus A. - Department of Molecular Physics, Wageningen Universiteit

 

Collection: Physics ; Biology and Medicine


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