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Sample search results for: a1 protease produced

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1 Breakthrough Technologies Activity Profiling of Papain-Like Cysteine Proteases
 

Summary:  serine, C1A cysteine and A1 aspartic protease families in Arabidopsis. Phytochemistry 65: 43­58 Beers EP... , most proteases are produced as pre-pro- proteases with a signal sequence, an autoinhibitory prodomain... Breakthrough Technologies Activity Profiling of ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
2 http://genomebiology.com/2002/3/4/reviews/3006.1 commentreviewsreportsdepositedresearchinteractionsinformationrefereedresearch
 

Summary:  , shown as stereo pairs. In the single-chain aspartic protease (b), the corresponding loops are labeled A1... activity at specific sites to produce mature, functional units. Active retroviral proteases are homodimers... of four struc- tural elements: a hairpin (containing loop ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
3 Increased Heterologous Protein Production in Aspergillus niger Fermentation through Extracellular Proteases Inhibition by
 

Summary:  derivative of N402 (18), and N402 is a cspA1 derivative of strain ATCC 9029. The GFP gene is fused... the protease secretion has not yet been elucidated. It is generally accepted that the proteases are produced... of a pellet size of 1.6 mm, which produced a specific ...

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
4 Biochemical Engineering Journal 8 (2001) 187193 Enhanced heterologous protein production in Aspergillus niger through
 

Summary:  402 [17] and N402 is a cspA1 derivative of strain ATCC 9029 [4]. The medium for A. niger cultures... will be species-specific, dependent on the particular spectrum of proteases produced by the strain. For instance... produces more neutral or alkaline proteases then a ...

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
5 I06 Biochemistry 1991, 30, 106-1 11 Wallace, C. J. A. (1987) J. Biol. Chem. 262, 16767-16770.
 

Summary:  by an anion-exchange column (Figure 4A1), while the HIV2 protease binds tightly and elutes with 1 M Na... -type homodimers produces catalytically defective heterodimers. Incubation of the HIVl or HIV2 protease with a 4... Verlag, Basel. Inhibition of HIV Protease ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
6 Journal of Clinical Immunology, Vol. 18, No. 3, 1998 Special Article
 

Summary:  the inter-a-trypsin inhibitor (123, 124) and a1-macroglobulin (125) families of protease inhibitors... , these inhibitors include a1-antichymotrypsin inhibitor, a1-proteinase inhibitor, secretory leukocyte proteinase... of Mast Cell ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
7 Identification of Structural Mechanisms of HIV-1 Protease Specificity Using Computational Peptide
 

Summary:  Hydrophobic Aromatic b-Branched Charged Polar P3 À0.25 À0.27 +0.69 -- +0.25 +0.36 P2 +0.41 +0.79 <<0.0a +1... Structure Article Identification of Structural Mechanisms of HIV-1 Protease Specificity Using... .str.2009.10.008 SUMMARY Drug-resistant mutations (DRMs) in HIV-1 protease are a major challenge

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Chemistry ; Biology and Medicine

 
8 2011NatureAmerica,Inc.Allrightsreserved. nature structural & molecular biology advance online publication
 

Summary:  .6 and 23.2%, respectively. The final model includes residues 1-55 and 60-124 in monomer A, 1-5, 12... publication b r i e F com mu n i cat i on s Crystal structure of XMRV protease differs from the structures... and protease) provides the most direct path to inactivation of the virus. It has already been ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
9 2003 NaturePublishing Group Proteases perform essential functions in all living
 

Summary:  -- the complete repertoire of proteases that are produced by these organisms. Because of the essential roles... and 9A1 have also generated two copies of genes that encode the single- copy human metalloproteases ADAM... © 2003 NaturePublishing Group Proteases perform essential functions ...

  

Source: Overall, Christopher M. - Department of Oral Biological and Medical Sciences, University of British Columbia

 

Collection: Biology and Medicine

 
10 G-Biosciences 1-800-628-7730 www.GBiosciences.com A handbook & selection guide for
 

Summary:  : Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibits Ca2+ -dependent... of protease & phosphatases & for proteases & assays Protease & Phosphatase Inhibitors & Proteases Protease... & ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
11 Protein Expression and Purification 24, 6170 (2002) doi:10.1006/prep.2001.1545, available online at http://www.idealibrary.com on
 

Summary:  A, gene encoding tmRNA in E. coli; LB, Luria­Bertani; DIG, digoxigenin; EOP, equivalent to a1 To whom... ) Autoprocessing and catalytically inactive MBP­TEV protease fusion proteins. pRK508 produces wild-type TEV... protease. pRK1033 produces a ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
12 A Protease Activity Displaying Some Thrombin-like Characteristics in
 

Summary:  , Jones AM, Dickerman A. 2004. The S8 serine, C1A cysteine, and A1 aspartic protease families... A Protease Activity Displaying Some Thrombin-like Characteristics in Conditioned Medium of Zinnia... proteases, respectively, have been shown to both trigger death and to execute autolysis as ...

  

Source: Jones, Alan M. - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
13 A Phytophthora infestans Cystatin-Like Protein Targets a Novel Tomato Papain-Like Apoplastic Protease1[W][OA]
 

Summary:  C1A-1 to C1A-8. To in- vestigate the relationship between PIP1 and other Cys proteases of plants, we... sequences. The sequences that have been assigned to eight tentative groups (C1A-1­C1A-8; Beers et al., 2004... Protease1[W][OA] Miaoying Tian3 , Joe Win2 , Jing ...

  

Source: van der Knaap, Esther - Department of Horticulture and Crop Science, Ohio State University

 

Collection: Biology and Medicine

 
14 DOI: 10.1002/cbic.201000442 Mechanisms of Macromolecular Protease Inhibitors
 

Summary:  . The serpins a1-anti- trypsin and antithrombin III,[48] purified from human plasma, are used as replacement... DOI: 10.1002/cbic.201000442 Mechanisms of Macromolecular Protease Inhibitors Christopher J. Farady... progression, to name but a few. Because proteases trigger an irreversible event--the cleavage of ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
15 10.1110/ps.035436.108Access the most recent version at doi: 2008 17: 2023-2037; originally published online Sep 29, 2008;Protein Sci.
 

Summary:  Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6... nucleoporin 98 1ko6 Ser864 His862 Clan SQ Family S58 Ochrobactrum anthropi aminopeptidase DmpA 1b65 Ser250... /His/Asp triad configuration Unconventional serine proteases: ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
16 Crystal Structure of a Novel Viral Protease with a Serine/Lysine Catalytic Dyad Mechanism
 

Summary:  , Canada V5A 1S6 2 Unite´ de Virologie et Immunologie Mole´culaires Institut National de la Recherche... are essential for activity (Figure 4). Ser692 resides just before helix a1 and Lys729 resides within helix a2... Crystal Structure of a Novel Viral Protease with a Serine/Lysine ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
17 The expanding diversity of serine hydrolases Istvan Botos1
 

Summary:  IgA1-specific serine peptidase S06.003 1WXR [16 ] NS3 protease S7 Flavivirin S07.001 2FOM,2FP7 [17... protease GlpG (2ic8). The core of the GlpG molecule is formed by six transmembrane helices (a1­a6... -linked homodimer [10] and cleaves factor IX. Each monomer has ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
18 nature structural & molecular biology VOLUME 18 NUMBER 2 FEBRUARY 2011 227 b r i e F com m u n i cat i o n s
 

Summary:  cat i o n s Crystal structure of XMRV protease differs from the structures of other retropepsins Mi Li... determined the crystal structure of the protease encoded by xenotropic murine leukemia virus­related virus... (XMRV). Despite overall similarity of XMRV protease to other retropepsins, the topology of its dimer

  

Source: Baker, David - Center for Nanotechnology and NanoTechnology & Department of Biochemistry, University of Washington at Seattle; Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
19 Biochem. J. (2002) 368, 273281 (Printed in Great Britain) 273 Critical role of amino acid 23 in mediating activity and specificity of
 

Summary:  primers (A1, 5h-CCAATATGCTATTAGAAAAAATC- 3h and B, 5h-GTGCTTATATTTTCCCTATCGG-3h). The same primers were... in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria... proteases of Plasmodium falciparum, known as falcipains, have been identified as ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
20 10.1110/ps.052069306Access the most recent version at doi: 2006 15: 1815-1828Protein Sci.
 

Summary:  , Michael R. proteases gleaned from investigations of isolated domains Slicing a protease: Structural... .proteinscience.orgDownloaded from #12;REVIEW Slicing a protease: Structural features of the ATP-dependent Lon proteases gleaned from... , USA Abstract ATP-dependent Lon proteases are ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine


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21 Biol. Chem., Vol. 385, pp. 525535, June 2004 Copyright by Walter de Gruyter Berlin New York 2004/401100
 

Summary:  is a key factor in wound healing processes. The Ecp protease inactivates a1-protease inhibitor, which seems... and inhibition by a2-macroglobulin The purified protease was incubated with a1PI at an enzyme:inhibitor molar... . This enzyme, with ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
22 pubs.acs.org/BiochemistryPublished on Web 05/12/2009r 2009 American Chemical Society Biochemistry 2009, 48, 57535759 5753
 

Summary:  University, South Science Building, 8888, University Drive, Burnaby, British Columbia, Canada V5A 1S6... of Bz-OSu to block the protease-exposed N-terminus produces doublet peaks separated by only 1 amu... 2009, 48, 5753­5759 5753 DOI: 10.1021/bi900461e Profiling the Substrate Specificity of Viral ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
23 NATURE BIOTECHNOLOGY VOL 18 AUGUST 2000 http://biotech.nature.com 847 Interactions between proteins play a critical role in cell function and
 

Summary:  protease. A1 through E8 are protease-coated surfaces to which 40 lysates were applied. Binding was detected... JH391 (J.C. Hu). A DNA fragment encoding D25N HIV-1 protease was produced by site-directed mutagenesis... (Molecular Dynamics, Sunnyvale, CA). ELISA. HIV-1 ...

  

Source: Park, Sang-Hyun - School of Biological Sciences, Seoul National University; Raines, Ronald T. - Departments of Biochemistry & Chemistry, University of Wisconsin at Madison

 

Collection: Biology and Medicine ; Chemistry

 
24 Biochem. J. (2004) 378, 529538 (Printed in Great Britain) 529 Identification and biochemical characterization of vivapains, cysteine
 

Summary:  -first-order equation y = A[1 - exp(- kobst) + B], where y is the fluorescence at time t, A the amplitude of the reac... characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax Byoung-Kuk NA*1... of California, San Francisco, CA 94143, U.S.A. Cysteine proteases play ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
25 Chem. Eng. Comm., 196:481490, 2009 Copyright 0Taylor & Francis Group, LLC
 

Summary:  ., 1987) and N402 is a cspA1 derivative of strain ATCC 9029 (Bos et al., 1988). The medium for A. niger... . niger predominantly produces aspartic (acid) proteases. Thus, it was not surprising... production can be I$-ell-describedby the model. The asstcmption that the degradation of GFP by ...

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
26 Comparison of the substrate specificity of two potyvirus Jo zsef To zser1
 

Summary:  proteases were produced in the form of maltose-binding protein fusion proteins which cleaved them- selves... protease were over- produced and purified as follows. BL21(DE3) CodonPlus RIL cells (Stratagene, La Jolla... Comparison of the substrate specificity of two potyvirus proteases Jo´ ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
27 Protein Expression and PuriWcation 38 (2004) 108115 www.elsevier.com/locate/yprep
 

Summary:  -TVMV protease fusion protein produced by pRK1035 cleaves itself at the designed TVMV recognition site... RK1037, which produces TVMV protease in response to anhydrotetracycline (aTet). The complete nucleotide... -optimized gene. To improve the solubility of the enzyme, TVMV protease was ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
28 Journal of Chemical Technology and Biotechnology J Chem Technol Biotechnol 78:12591266 (online: 2003) DOI: 10.1002/jctb.898
 

Summary:  interleukin-6, bovine chymosin, and porcine pancreatic phospholi- pase A.1,2 A fungal fermentation system... by the host. The strain AB4.1 is a pyrG1 derivative of N402 3 and N402 is a cspA1 derivative of strain ATCC... . However, heterologous protein production is often severely hampered by fungal ...

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
29 An overview of enzymatic reagents for the removal of affinity tags David S. Waugh
 

Summary:  the serine proteases, large quantities of recombinant viral proteases can easily be produced in Escherichia... protease; there is virtually no opportunity to produce a recombinant protein with a native N-terminus after... protein was cleaved in vivo, using a separate plasmid expression ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
30 Product Contents ProTEV Protease
 

Summary:  M DTT V6051 1,000 units V605A V602A (1ml) P117B (250µl) V6052 10,000 units V605B V602B (8ml) P117C (1... Product Contents ProTEV Protease: Supplied With: Cat.# Size ProTEV Protease ProTEV Buffer, 20X 100m... .25ml) Description: ProTEV Protease is an engineered form of TEV ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
31 Our view of the proteolytic universe has expanded con-siderably in recent years.PROTEASES were initially charac-
 

Summary:  that are specific for the different protease inhibitors that are produced by an organism. These chips can be used... Our view of the proteolytic universe has expanded con- siderably in recent years.PROTEASES were... . Proteases, through their ability to catalyse irreversible hydrolytic reactions,regu- late the ...

  

Source: Overall, Christopher M. - Department of Oral Biological and Medical Sciences, University of British Columbia

 

Collection: Biology and Medicine

 
32 Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions.
 

Summary:  and Pseudomonas strains that produce protease IV are highly damaging to rabbit and mouse corneas while strains... the degradation of SP-D by different biologically produced proteases. P. aeruginosa elastase, a zinc... 'Callaghan RJ. Pseudomonas aeruginosa protease IV ...

  

Source: Hogan, Brigid L.M. - Department of Cell Biology, Duke University; Wright, Jo Rae - Department of Cell Biology, Duke University

 

Collection: Biology and Medicine

 
33 Protease Assay Kit TB252 11/99 Novagen 1
 

Summary:  absorbance at 340 nm (A1 ) after about 1 min. After exactly another 2 min measure absorbance A2 . Calculate A... 2 - A1 = A per 2 min. Micro-assays For a micro-assay all volumes stated can be halved. Measure... of samples 1 to 4 at 150, 150½, 151, 151½ min Measuring of ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
34 SUMO Protease Cat. No. 12588-018 Size: 250 units
 

Summary:  SUMO Protease Cat. No. 12588-018 Size: 250 units Description SUMO Protease, a highly active... cysteinyl protease also known as Ulp, is a recombinant fragment of Ulp1 (Ubl-specific protease 1) from... Saccharomyces cerevisiae (1). SUMO Protease cleaves in a highly specific manner, ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
35 The variable detergent sensitivity of proteases that are utilized for recombinant protein affinity tag removal
 

Summary:  The variable detergent sensitivity of proteases that are utilized for recombinant protein affinity... online 24 April 2011 Keywords: Proteases Detergent stability Membrane proteins a b s t r a c... . Expression constructs with affinity tags often include an engineered protease site for tag removal. Like

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
36 letters to nature NATURE |VOL 407 |19 OCTOBER 2000 |www.nature.com 923
 

Summary:  , the archetypal member of the family, a1-antitrypsin7,8 . There have been many unsuccessful attempts over the past... containing an excess of a1-antitrypsin over trypsin, and set up crystallization trials at 4 8C. Crystals were... of a1-antitrypsin in the complex is ...

  

Source: Read, Randy J. - Department of Haematology, University of Cambridge

 

Collection: Biology and Medicine

 
37 Viral Proteases Department of Biological Sciences, Columbia University, New York, New York 10027
 

Summary:  Is Essential for Producing Infectious Virions 4621 B. Structure of Adenovirus Protease 4621 C. Cofactors... Viral Proteases Liang Tong Department of Biological Sciences, Columbia University, New York, New... Proteases 4610 A. Capsid Protein Autoprotease of Alphaviruses 4612 1. Functions of the Capsid Protein ...

  

Source: Tong, Liang - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
38 MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/00/$04.00 0
 

Summary:  produces a mono- cistronic mRNA encoding a VP1-2A fusion protein from which the 2A protease is released... to produce a bicistronic mRNA that has the potential to encode twice of the amount of 2A protease... ). As we dem- onstrate here also in our 2A protease-producing cells, eIF4GII is ...

  

Source: Kahana, Chaim - Department of Molecular Genetics, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
39 [M189]. Mirabilysin MEROPS name: Mirabilysin[M189]P001
 

Summary:  to as an IgA protease because of its activity on both serum and secretory forms of IgA1 (immunoglobulin A1... agar (Wassif et al., 1995). Many strains of P. mirabilis produce this protease, also referred... mirabilysin. Both human serum ...

  

Source: Belas, M. Robert - Center of Marine Biotechnology, University of Maryland Biotechnology Institute

 

Collection: Biology and Medicine

 
40 Chemistry & Biology Peptide Length and Leaving-Group Sterics Influence
 

Summary:  a = 79.9 A° b = 80.2 A° c = 40.5 A° b = 95.8 Resolution (last shell) 54.6­1.19 A° (1.25­1.19 A° ) Unique... Phosphonate Protease Inhibitors Christopher M. Brown,1,5 Manisha Ray,1,5 Aura A. Eroy-Reveles,2 Pascal Egea,3... an analysis of parameters influencing potency of peptide phosphonate ABPs for trypsin- fold S1A ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine


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41 INSTRUCTIONS Pierce Biotechnology PO Box 117 (815) 968-0747 www.thermo.com/pierce
 

Summary:  activity Sample contains high levels of proteases or phosphatases Add sufficient cocktail to produce a 2X... Road Rockford, lL 61105 USA (815) 968-7316 fax Number Description 78440 Halt Protease and Phosphatase... Inhibitor Cocktail, sufficient for 100 ml of sample Contents: Protease and Phosphatase ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
42 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Urokinase-type plasminogen activator is a preferred substrate of the human
 

Summary:  , pepstatin, aprotinin (Roche Diagnostics, Indianapolis, IN), purified human 1- antitrypsin (A1AT; also known... , data not shown). A1AT and SLPI are effective inhibitors of TMT/tryptase /PRSS31.31 Even though... A1AT nor SLPI was able to inhibit tryptase (Table 2). ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
43 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 55825587, May 1997
 

Summary:  , salt-washed vacuoles were incubated with ATP alone, 30 g of I2 B -wild-type cytosol (K91-1A), 1.2 g... and protease B inhibitor 2 (I2 B ). Here we show that the second low molecular weight activity (LMA2... ) is monomeric I2 B . Though LMA2 I2 B was initially identified as a protease B inhibitor, this ...

  

Source: Haas, Albert - Institute for Cell Biology, Universität Bonn

 

Collection: Biology and Medicine

 
44 Analysis of Methods for Predicting Protein Fold and Remote Homologue Recognition
 

Summary:  ). Upon selection, the method generates 1D-PSSM or 1D-profile using PSI- Blast (A0,A1,A2...). Next... the random process that produces these sounds with high probability. In speech recognition, the "alphabet... the model. One of its main uses is to produce multiple alignments of homologs of the target ...

  

Source: Bejerano, Gill - Departments of Computer Science & Developmental Biology, Stanford University

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
45 Crystal Structure of the VP4 Protease from Infectious Pancreatic Necrosis Virus Reveals the Acyl-Enzyme Complex
 

Summary:  Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada and § Unite... , Simon Fraser University, South Science Bldg., 8888 Uni- versity Dr., Burnaby, British Columbia V5A 1S6... protease construct (VP4_524­716,K674A) that ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
46 A Model of Tumour Angiogenesis and
 

Summary:  respond to a VEGF stimulus by producing protease, which degrades the basement membrane and eventually... , where it binds to receptors on the surface of EC. This stimulates the EC to produce a protease, which... continue to produce protease in the ECM and can thus ...

  

Source: Plank, Mike - Department of Mathematics and Statistics, University of Canterbury

 

Collection: Mathematics

 
47 Structure of the Archaeal Pab87 Peptidase Reveals a Novel Self-Compartmentalizing Protease Family
 

Summary:  and refinement statistics. Lu-HPDO3A derivative Data collection X-ray source ESRF ID29 Wavelength (A°) 1... Structure of the Archaeal Pab87 Peptidase Reveals a Novel Self-Compartmentalizing Protease Family... Abstract Self-compartmentalizing proteases orchestrate protein turnover through an original ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
48 The 0.83 A Resolution Crystal Structure of a-Lytic Protease Reveals the Detailed Structure of the Active
 

Summary:  A. Data collection Resolution range (A° ) 1.7­0.78 1-1.12 Detector distance (mm) 99 200 MAR plate... The 0.83 A° Resolution Crystal Structure of a-Lytic Protease Reveals the Detailed Structure... Francisco, CA 94143-2240 USA The crystal structure of the extracellular bacterial serine protease a

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
49 BIOINFORMATICS Vol. 19 no. 1 2003
 

Summary:  of Ligplot for a protease bound with Indinavir is presented in Figure 2. The structures produced by Modeler... L10I I15V M36I G48V I54V I62V V82A 1.18 39 L10I I15V M36I G48V I54V I62V 0.92 30.67 K14R I15V N37D F... the failure of current HIV therapies. The ability to predict the drug resistance of HIV ...

  

Source: Draghici, Sorin - Department of Computer Science, Wayne State University

 

Collection: Computer Technologies and Information Sciences

 
50 A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
 

Summary:  . As in previous sys- tems to produce the NS3 protease [48], DNA encoding 12 residues of the NS4A protein of HCV... to 1.5 mm), and enzyme (1.5 nm for wild-type RNase A; 1 and 3 lm for the 1C and 2C unactivated zymogens... A ribonuclease zymogen activated by the NS3 protease of the ...

  

Source: Raines, Ronald T. - Departments of Biochemistry & Chemistry, University of Wisconsin at Madison

 

Collection: Chemistry ; Biology and Medicine

 
51 Inhibition of R-Lytic Protease by Pro Region C-Terminal Steric Occlusion of the Active Site
 

Summary:  29487) is used to produce wild-type R-lytic protease. Liquid cultures of Lysobacter were grown... Inhibition of R-Lytic Protease by Pro Region C-Terminal Steric Occlusion of the Active Site Julie L... Vised Manuscript ReceiVed January 23, 1997X ABSTRACT: R-Lytic protease, a chymotrypsin-like serine ...

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco; Rader, Stephen - Chemistry Program, University of Northern British Columbia

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
52 Enhanced Proteome Profiling by Inhibiting Proteolysis with Small Heat Shock Proteins
 

Summary:  (supE44 hsdR17 recA1 gyrA96 thi relA1 lac F [proAB+ laclq lacZM15 Tn10 [Tetr ]]; Stratagene Cloning... sections are shown in Figure 3A1-4,B1-4). For human serum, approximately 710 spots were obtained... than those obtainable with currently available ...

  

Source: Korea Advanced Institute of Science and Technology, Department of Chemical and Biomolecular Engineering, Metabolic & Biomolecular Engineering National Research Laboratory

 

Collection: Engineering ; Biotechnology

 
53 Hemoglobin Degradation in the Human Malaria Pathogen Plasmodium falciparum: A Catabolic
 

Summary:  summarized in Table 3. At late time points the a34-141 peptide signal diminished, while that of a1... -33 persisted. Note that all the secondary cleavage products are fragments of the original a1-33 and 34... , corresponding to a1-105 was detected. The enzyme can ...

  

Source: Chait, Brian T. - Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University

 

Collection: Biology and Medicine

 
54 Computational Coevolution of Antiviral Drug Resistance Christopher D. Rosin 1;2 , Richard K. Belew 2 , Garrett M. Morris 1 ,
 

Summary:  resistance. Data on HIV­1 protease are used to derive an approximate model that predicts interaction... of a wide range of mutant forms of the protease with a broad class of protease inhibitors. An algorithm... based on competitive coevolution is used to find highly resistant mutant forms of the protease

  

Source: Belew, Richard K. - Departments of Computer Science and Engineering & Cognitive Science, University of California at San Diego

 

Collection: Computer Technologies and Information Sciences

 
55 Original Article Novel Antifoulants: Inhibition of Larval Attachment by Proteases
 

Summary:  of the bacteria that formed inhibitive biofilms produced proteases. Our investigation demonstrated the potential... for the larval settlement bioassay. The protease produced by the strain D12-004 (Pseudoalteromonas issachenkonii... identification showed that all of deep-sea bacterial isolates that ...

  

Source: Levin, Lisa - Integrative Oceanography Division, Scripps Institution of Oceanography

 

Collection: Environmental Sciences and Ecology

 
56 Temperature Effects on Product-Quality-Related Enzymes in Batch CHO Cell Cultures Producing Recombinant tPA
 

Summary:  Temperature Effects on Product-Quality-Related Enzymes in Batch CHO Cell Cultures Producing... that enzymes, such as proteases and sialidases, accumulate in batch bioreactors. These enzymes are known... on the production of proteases and sialidases has not been investigated. In this study, Chinese hamster ovary cells

  

Source: Tullos, Desiree - Department of Biological and Ecological Engineering, Oregon State University

 

Collection: Environmental Sciences and Ecology

 
57 An Autoinhibited Coiled-Coil Design Strategy for Split-Protein Protease Sensors
 

Summary:  An Autoinhibited Coiled-Coil Design Strategy for Split-Protein Protease Sensors Sujan S. Shekhawat... Versity of Arizona, Tucson, Arizona 85721 Received June 26, 2009; E-mail: ghosh@email.arizona.edu Abstract: Proteases... for the design of a family of genetically encoded turn-on protease biosensors. In our design, an ...

  

Source: Ghosh, Indraneel - Department of Chemistry and Biochemistry, University of Arizona

 

Collection: Chemistry

 
58 RESEARCH ARTICLE Liberation of SARS-CoV main protease from the viral
 

Summary:  : (f) R4E, 1 mM; (g) R298E, 1 mM; (h) E290R, 1 mM; (i) C145A, 1 mM. © Higher Education Press... Scission protease was then added to cleave off the C-terminal GPH6 tag, producing an authentic mature SARS-CoV Mpro... RESEARCH ARTICLE Liberation of SARS-CoV main protease from the viral ...

  

Source: 

 

Collection: Computer Technologies and Information Sciences

 
59 Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a Lysine Recruited to the Nonconserved Amino-Terminal Domain in the S49 Protease
 

Summary:  , Simon Fraser UniVersity, Burnaby, British Columbia V5A 1S6, Canada, The Skaggs Institute for Chemical... , ompF627(T2 R ), glpA24, fadL701(T2 R ), relA1, glpR8(glpc ), glpR7 (glpn ), glpD26, pit-10, spoT1... Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
60 Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a Lysine Recruited to the Nonconserved Amino-Terminal Domain in the S49 Protease
 

Summary:  , Simon Fraser UniVersity, Burnaby, British Columbia V5A 1S6, Canada, The Skaggs Institute for Chemical... , ompF627(T2 R ), glpA24, fadL701(T2 R ), relA1, glpR8(glpc ), glpR7 (glpn ), glpD26, pit-10, spoT1... Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine


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61 Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease*
 

Summary:  expression vector (pRK529) is identical to pKM607 (15), except that the protease produced by pRK529 does... PCR (16) using pRK508 (17) as the template. The His6- TEV(C151A) protease was produced as an MBP... in the linker to remove the MBP domain. Both forms of TEV protease were ...

  

Source: Waugh, David S.- Macromolecular Crystallography Laboratory, National Cancer Institute; Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Biology and Medicine ; Chemistry

 
62 The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis
 

Summary:  The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis Eric P. Beersa... proteases (family A1) and the plant matrixin, metalloproteases (family M10A). In this report, 54 subtilisin... -like, 30 papain-like and 59 pepsin-like ...

  

Source: Jones, Alan M. - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
63 The Table of Interface Forming Residues as the Specificity Indicator for Serine Proteases Bound to
 

Summary:  The Table of Interface Forming Residues as the Specificity Indicator for Serine Proteases Bound... proteases specificity determining interface forming residues (IFR). The IFR are obtained by "hard body... docking" among 73 structurally aligned, sequence wise non redundant, serine protease structures, with 3

  

Source: Neshich, Goran - Brazilian Agricultural Research Corporation & Instituto de Biologia, Universidade Estadual de Campinas

 

Collection: Biology and Medicine

 
64 Inhibition of extracellular protease secretion by Aspergillus niger using cell
 

Summary:  Inhibition of extracellular protease secretion by Aspergillus niger using cell immobilization Fang... was employed as a model to investigate the effect of cell immobilization on extracellular protease secretion... protease from immobilized cells was reduced from 129 units/g to 28 units/g. Introduction The ability

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
65 r XXXX American Chemical Society A dx.doi.org/10.1021/ja109377p |J. Am. Chem. Soc. XXXX, XXX, 000000 COMMUNICATION
 

Summary:  / 0256324 A1, November 17, 2005. (14) Kaneshiro, T. L.; Wang, X.; Lu, Z.-R. Mol. Pharmaceutics 2007, 4, 759... ­000 COMMUNICATION pubs.acs.org/JACS HIV Protease-Mediated Activation of Sterically Capped Proteasome Inhibitors... a cytotoxic, small- molecule proteasome inhibitor upon cleavage by HIV-1 protease. ...

  

Source: Crews, Craig M. - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Chemistry ; Biology and Medicine

 
66 Coming Soon! SigmaFASTTM Protease Inhibitor Tablet for General Use (Cat. No. S8820)
 

Summary:  M Aprotinin, 80 µM Bestatin, 4 mM E-64, 1.4 mM Leupeptin, 2 mM Pepstain A, 1.5 mM AEBSF Bestatin E-64... Coming Soon! SigmaFASTTM Protease Inhibitor Tablet for General Use (Cat. No. S8820) Sample Type... Serine, Cysteine, Aspartic Proteases & Amidopeptidases Serine, Cysteine, Aspartic and Metalloproteases

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
67 The role of I;`0 regions in protein folding David Baker, Andrew K Shiau and David A Agard
 

Summary:  :7377. The precursor of aqualysin I. an cxtrdccllular protease produced by Thermru aquurfcxs, contains amino... University of California, San Francisco, USA In vivo, many proteases are synthesized as larger precursors... . During the maturation process, the catalytically active protease domain is released from ...

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
68 Isolation and characterization of a rice cysteine protease gene, OsCP1, using T-DNA gene-trap system
 

Summary:  gene encodes a novel phospholipase A1 catalyzing the initial step of jasmonic acid biosynthesis, which... Isolation and characterization of a rice cysteine protease gene, OsCP1, using T-DNA gene... , cell death, cysteine protease, rice, tapetum, T-DNA insertional mutagenesis Abstract The T-DNA gene

  

Source: An, Gynheung - Department of Life Science, Pohang University of Science and Technology

 

Collection: Biotechnology ; Biology and Medicine

 
69 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 11002-11007, October 1996
 

Summary:  CO 0 0 a.1-- b C I ITl TTTt- l- - llFlTF 0.0 0.06 0.25 0.0 0.1 0.2 0.4 0.1 1 10 100 1000 Granzyme B... 17 and poly(ADP-ribose) polymerase is cleaved indicating that this protease although activated... -dependent cell death pathway in some cell types and requires a CPP32-like Ac-DEVD-CHO inhibitable protease ...

  

Source: 

 

Collection: Biology and Medicine

 
70 Developmental Cell 10, 4555, January, 2006 2006 Elsevier Inc. DOI 10.1016/j.devcel.2005.11.013 A Spatzle-Processing Enzyme Required for Toll
 

Summary:  , we purified it from silkworm hemolymph (Figures 1A­1C). BAEEase was purified in a zymogen form... of innate immunity from insects to humans. Although in Drosophila the Easter protease processes the pro- Spa... ¨tzle protein to generate the Toll ligand during de- velopment, the identification of the ...

  

Source: Lemaitre, Bruno - Centre de Génétique Moléculaire, CNRS

 

Collection: Biology and Medicine

 
71 Biochem. J. (2011) 435, 116 (Printed in Great Britain) doi:10.1042/BJ20100965 1 REVIEW ARTICLE
 

Summary:  . Streptokinase is a protease activator produced by -haemolytic streptococci that has been approved as a way... , the protease produced by t-PA activity in vivo. Approaches to extending the half-life of t-PA and other... Proteases as therapeutics Charles S. CRAIK*1 , Michael J. PAGE* and ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
72 Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila*
 

Summary:  proteases, MP1 and MP2. A, the null mutation spn27A1 for the serpin Spn27A results in constitutive... -type strain unless otherwise indicated. The spzrm7 (2), relE20 (18), and spn27A1 (16) mutations, as well... . The Bloomington Stock Cen- ter was the source of all other stocks. In our ...

  

Source: Lemaitre, Bruno - Centre de Génétique Moléculaire, CNRS

 

Collection: Biology and Medicine

 
73 Molecular Cell 23, 2535, July 7, 2006 2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.05.019 A Branched Pathway Governing the Activation
 

Summary:  protease (His-A1,3,4 in Figure 3B). To test whether these mutants blocked cleavage by IVB in the context... ., 2000) are shown. (B) Purified His-A and cleavage site 1 mutant (S155R), His-A1 ; and cleavage sites 1... , 3, and 4 mutant (S155R, S117R, and A106R), His- ...

  

Source: Rudner, David - Department of Microbiology and Molecular Genetics, Harvard University

 

Collection: Biology and Medicine

 
74 1999 Macmillan Magazines Ltd he ice-binding antifreeze glycoprotein
 

Summary:  -- transcriptionally active chimaeric genes that encode both an AFGP poly- protein and the protease, confirming... the protease origin of AFGP and indicating how it was created. AFGP binds to and arrests the growth of ice... - protein; post-translational removal of the spacers produces many copies of mature AFGP per gene2

  

Source: Cheng, Chi-Hing Christina - Department of Animal Biology, University of Illinois at Urbana-Champaign

 

Collection: Environmental Sciences and Ecology

 
75 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1100811014, September 1999
 

Summary:  stability as a mechanism for protease longevity ERIN L. CUNNINGHAM, SHEILA S. JASWAL, JULIE L. SOHL... of the extracellular serine pro- tease, -lytic protease ( LP; EC 3.4.21.12) reveals a novel mechanism for stability... that appears to lead to a longer functional lifetime for the protease. For LP, stability is based

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
76 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1105411061, September 1999
 

Summary:  proteases hepsin (25) and TMPRSS2 (32) are only predicted based on sequence homology. To produce active... biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify... a membrane- type serine protease in epithelial cancer and normal tissue TOSHIHIKO ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
77 DISEASES OF AQUATIC ORGANISMS Dis Aquat Org
 

Summary:  is the location of initial ciliate invasion. In several other parasitic infections, proteases released... , some parasite proteases degrade host extracellular matrix proteins, thus facilitating spread... pathogens secrete proteases during in vitro culture, suggesting that protease release could be im- portant

  

Source: Graves, John E. - Virginia Institute of Marine Science, College of William and Mary

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
78 specificity of tobacco etch virus protease Rachel B. Kapust,a
 

Summary:  producing both TEV protease and one of twenty oth- erwise identical MBP­NusG proteins with different amino... The P10 specificity of tobacco etch virus protease Rachel B. Kapust,a Joozsef Toozseer,b Terry D... specificity of the tobacco etch virus (TEV) protease has made it a useful reagent for this purpose. ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
79 The Rockefeller University Press $30.00 J. Exp. Med.
 

Summary:  - mycin A1. Measure of protease inhibitor efficiency. 106 RAW cells were plated and incubated for 1 h... to as high-migrating [hm] TLR9; Ewald et al., 2008). Treatment with bafilomycinA1, an inhibitor... cleavage to an extent equivalent to treatment with bafilomycin ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
80 Biochemistry 1991, 30, 2263-2272 2263 Steitz, T. A,, & Shulman, R. G. (1982) Annu. Rev. Biophys.
 

Summary:  Structures of a-Lytic Protease Complexes with Irreversibly Bound Phosphonate Esters+?$ Roger Bone,sJ Nicole S... of the complexes with a-lytic protease of both phosphorus stereoisomers of N-[(2S)-2-[ [[(1R)-l - [ N [(tert... an understanding for the structural basis of serine protease catalysis, the structures of many serine ...

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine


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81 The Plant Cell, Vol. 10, 12171228, July 1998, www.plantcell.org 1998 American Society of Plant Physiologists A Cytoplasmic Male SterilityAssociated Mitochondrial
 

Summary:  ) produced in the absence and presence of an added protease inhibitor (vanadate, Van). No Inhib indicates... [C] and 9.1 kb [J]). Both RFLPs mapped to linkage group A, 1.4 centimorgans (LOD 17.7) away from... demonstrated accumulation of ORF239 only when a protease inhibitor was included. ...

  

Source: Mackenzie, Sally A. - Plant Science Initiative & School of Biological Sciences, University of Nebraska-Lincoln

 

Collection: Biology and Medicine

 
82 10394 Pacific Center Court San Diego, CA 92121
 

Summary:  aldehyde protease inhibitor produced by H2O 1 - 100 µM 11, 12 actinomycetes. Inhibitor of Ca2+-dependent... -3417 Technical Service: (800) 628-8470 Fax: (800) 776-0999 Acetyl-Pepstatin 110175 643.8 An aspartyl protease... . Irreversible inhibitor of H2O 0.1 - 1 mM 2, 3 serine proteases. Reacts covalently with ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
83 GENETIC OR CHEMICAL PROTEASE INHIBITION CAUSES SIGNIFICANT CHANGES IN THE BACILLUS SUBTILIS
 

Summary:  CHAPTER 6 GENETIC OR CHEMICAL PROTEASE INHIBITION CAUSES SIGNIFICANT CHANGES IN THE BACILLUS... and therapeutic proteins 92 SUMMARY Bacillus subtilis is a prolific producer of enzymes and biopharmaceuticals... . However, the susceptibility of heterologous proteins to degradation by (extracellular) proteases

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
84 SUMOstarTM Gene Fusion Technology NEW METHODS FOR ENHANCING FUNCTIONAL PROTEIN
 

Summary:  . SUMO Protease and Purification of Untagged Proteins While ubiquitin fusion has been known for many... by hydrolysing the peptide bond. Likewise, commonly used proteases such as thrombin, enterokinase, rhinovirus... proteases, and TEV, do not cleave all fusions efficiently and, moreover, can generate unnatural N

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
85 Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite
 

Summary:  of these two proteins. Several differences were of note (Fig. 7). First, while the procathepsin L a1 helix... from binding due to a steric clash between the occluding loop and the prodomain residues connecting a1... to this observation. In the model, the interaction of the helices equivalent to cathepsin L ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
86 Full Quantum Mechanical Study of Binding of HIV-1 Protease Drugs
 

Summary:  Full Quantum Mechanical Study of Binding of HIV-1 Protease Drugs DA W. ZHANG, JOHN Z. H. ZHANG... protease and six FDA (Food and Drug Administration)-approved drugs (saquinavir, indinavir, ritonavir... fractionation with conjugate caps) method. The MFCC calculation produces a quantum mechanical interaction

  

Source: Zhang, John Z.H. - Department of Chemistry, New York University

 

Collection: Chemistry

 
87 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1101511022, September 1999
 

Summary:  protease inhibitors as chemotherapy: Lessons from a parasite target PAUL M. SELZER*, SABINE PINGEL, IVY... , Germany ABSTRACT Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion... , selectivity, and safety of cysteine protease inhibitors in cell culture or in vivo. We now report

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
88 FRET-Based Optical Assay for Monitoring Riboswitch Svetlana Harbaugh,
 

Summary:  as the negative control culture, which produced a mutant, that is, inactive TEV protease; thus, the "off" state... cleavage is a benefit, however the additional requirement of cells producing the protease delays signal... the translation of TEV protease, the REACh protein quenches the ...

  

Source: U.S. Army Medical Research and Materiel Command's Bioinformatics Cell, Biotechnology High Performance Computing Software Applications Institute

 

Collection: Computer Technologies and Information Sciences ; Biotechnology

 
89 Research Letters AIDS 2005, 19:529533
 

Summary:  Research Letters AIDS 2005, 19:529­533 Virtual screening of HIV-1 protease inhibitors against human... cytomegalovirus protease using docking and molecular dynamics Ekachai Jenwitheesuk and Ram Samudrala The clearance... protease by HIV-1 protease inhibitors contained in highly active anti- retroviral ...

  

Source: Samudrala, Ram - Department of Microbiology, University of Washington at Seattle

 

Collection: Biotechnology ; Biology and Medicine

 
90 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, May 2006, p. 37103715 Vol. 72, No. 5 0099-2240/06/$08.00 0 doi:10.1128/AEM.72.5.37103715.2006
 

Summary:  ), to produce mature viral proteins (31, 46, 52). The 2Apro of enteroviruses is a cysteine protease... . Qualitative examination of infectious viruses Virus Detection at the following virus titer (PFU)a 1 10 100 1... indicator composed of a linker peptide, which is exclusively cleaved by the 2A ...

  

Source: Chen, Wilfred - Department of Chemical and Environmental Engineering, University of California at Riverside

 

Collection: Biotechnology ; Environmental Management and Restoration Technologies

 
91 Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates
 

Summary:  , cysteine proteases, from both malaria parasites and humans. It is produced from soon before until soon... Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion... , Stanford, California, United States of America Erythrocytic malaria parasites utilize proteases

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
92 Nature Macmillan Publishers Ltd 1998 intact protein antigens6
 

Summary:  proteases must work in concert to deliver a carefully orchestrated series of cuts... in antigen presentation7,8 , indicating that other proteases are involved in both removing Ii and converting... the antigen into peptides. One might assume, perhaps naively, that many lysosomal proteases are functionally

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
93 10.1101/gad.1440606Access the most recent version at doi: 2006 20: 1911-1922; originally published online Jun 30, 2006;Genes & Dev.
 

Summary:  a mutation of the gene (yluC) for the Site-2 protease into cells producing the Flag-tagged anti- factor... W thrC prsWH175A 1.48 0.06 prsW thrC prsWE75A E76A 1.60 0.10 a All strains contain amyE PsigW-lacZ (cat... and resistance to antimicrobial peptides in Evidence ...

  

Source: Losick, Richard M. - Department of Molecular and Cellular Biology, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
94 Crystal Structure of a Bacterial Signal Peptide Peptidase Apollos C. Kim, David C. Oliver and Mark Paetzel
 

Summary:  , 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6 Received 21 September 2007; received... in the periplasmic Ser/Lys protease SppA and the monomers seen in the cytoplasmic Ser/His/Asp protease ClpP. We... ; protease IV; Ser/Lys dyad; Lysine general-base; serine ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
95 *Department of Animal Physiology, Ruhr-University of Bochum, Bochum, Germany Biofrontera Bioscience GmbH, Leverkusen, Germany
 

Summary:  (1 : 400), polyclonal goat anti-mouse TNF-a (1 : 500), polyclonal rabbit anti-mouse COX-2 (1 : 1000... and produce an excess of cytotoxic factors like superoxide, nitric oxide, and tumor necrosis factor-a (TNF... to diverse cytokines, activated microglia secrete certain lysosomal proteases, the cathepsins ...

  

Source: Lübbert, Hermann - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
96 Secretory Production of Recombinant Protein by a High Cell Density Culture of a Protease Negative Mutant Escherichia coli
 

Summary:  envelope proteases, grew slightly faster and produced more fusion protein than the other strains deficient... protein, could be produced to a higher extent in this protease negative mutant compared with the parent... Secretory Production of Recombinant Protein by a High Cell Density Culture of a ...

  

Source: Korea Advanced Institute of Science and Technology, Department of Chemical and Biomolecular Engineering, Metabolic & Biomolecular Engineering National Research Laboratory

 

Collection: Engineering ; Biotechnology

 
97 Atomic-resolution Crystal Structure of the Proteolytic Domain of Archaeoglobus fulgidus Lon Reveals the
 

Summary:  Native D508A E506A Native Native Resolution (A° ) 1.2 1.55 1.55 2.3 2.05 R (%)a 13.7 (13.0)b 21.3 17.9 19... . The cell-free extract was diluted twofold with buffer A1 (buffer A containing 10% (v/v) glycerol... ) and applied at 1 ml/minute to a 100 ml P-11 column pre-equilibrated with buffer ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
98 Author's personal copy Journal of Theoretical Biology 253 (2008) 2435
 

Summary:  in terms of four states, namely healthy (T), infected stage 1 (A1), where the cell is infected and able... whether a cell should go into the actively infected (A1) state with a probability Pinf or the latently... reveals that the coefficients of DTÃ n form an arithmetic series in the form of an ¼ ...

  

Source: Kuang, Yang - Department of Mathematics and Statistics, Arizona State University

 

Collection: Mathematics

 
99 The International Journal of Biochemistry & Cell Biology 41 (2009) 16011612 Contents lists available at ScienceDirect
 

Summary:  incubated with the general cys- teine protease inhibitor, E-64, while E-64-c only produced a 33% loss... .53 1348.3 ND ND ND Boc-Asp-Pro-Arg-AMC 0.69 0.35 1976.3 0.28a 1.16a 244.35 D-Val-Leu-Arg-AMC 0.14a 4.53a... .elsevier.com/locate/biocel A major cathepsin B protease from the liver ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
100 Comparative Assessment of Substrates and Activity Based Probes as Tools for Non-Invasive Optical Imaging
 

Summary:  of reagents have been built around reporter substrates that, when cleaved by a protease, produce a fluorescent... produced upon reaction with the target protease [3]. The major difference between ABPs and substrates... Imaging of Cysteine Protease Activity Galia Blum1¤ , Robby M. ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine


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