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Sample search results for: aba4-1 mutant reveals

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1 Investigations of the Software Testing Coupling Effect
 

Summary:  ­order mutants, or complex mutants, are mutants that are generated by introducing multiple mutations... into the program, then it is clear that many higher­order mutants are complex faults. We also expect... that there are complex faults that cannot be generated by higher­order mutants ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
2 Investigations of the Software Testing Coupling E ect
 

Summary:  to a source statement. Thus, mutations introduce simple faults into a program. If higher-order mutants... , or complex mutants, are mutants that are generated by introducing multiple mutations into the program... , then it is clear that many higher-order mutants are complex faults. We also expect that there ...

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
3 Incomplete dominance for flower colour in Mirabilis jalapa R1 Red pigment
 

Summary:  Crosses reveal each white mutant results from single gene. That is, if you cross the mutant to wild type... ornithine citrulline argenine arg-1 mutant can't make ornithine arg-2 mutant can't make citrulline arg-3... mutant can't make argenine #12;Inferring Gene ...

  

Source: Shore, Joel S. - Department of Biology, York University (Toronto)

 

Collection: Biology and Medicine

 
4 A Probabilistic Model for Effective Mutation Mohan Sridharan
 

Summary:  with evaluating an enormous number of mutants with the entire pool of test cases. The test pool is typically... augmented to account for mutants that remain unexposed after such an analysis. It can be argued that a test... pool capable of detecting certain types of mutants is also capable of exposing other similar ...

  

Source: Sridharan, Mohan - Department of Computer Science, Texas Tech University

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
5 A Manifesto for Higher Order Mutation Testing Mark Harman, Yue Jia and William B. Langdon
 

Summary:  are not accidental but indicate structure. Analysis of high order mutants, even very high order, has revealed... ­to­kill higher order mutants and, simultaneously, sets of very good quality test cases that are adapted to reveal... cases are insufficiently good to reveal them. Such ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
6 On Guiding the Augmentation of an Automated Test Suite via Mutation Mutation testing has traditionally been used as a defect injection technique to assess the effectiveness of a test
 

Summary:  reveal the same test deficiency. Stubborn and similar mutants can cause the mutation process... by test sets already written to kill method-level mutants. The study also revealed that two class... cases until the test suite is sufficient to detect as many mutants as possible and the ...

  

Source: Reeves, Douglas S. - Department of Computer Science, North Carolina State University

 

Collection: Computer Technologies and Information Sciences

 
7 Mutation Clustering Shamaila Hussain
 

Summary:  . The computational cost is due to too many mutants for even small programs. We have experimented with different... to reduce the computational cost of the mutation testing, reducing the number of the mutants by clustering... to cluster the mutants. Thereby, re- ducing the size of mutants by selecting one ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
8 MuJava : An Automated Class Mutation System Yu-Seung Ma1
 

Summary:  of mutation testing for OO programs by using two key technologies, Mutant Schemata Generation (MSG... ) and bytecode translation. This method adapts the existing MSG method for mutants that change the program... behavior and uses bytecode translation for mutants that change the program structure. A key advantage

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
9 How the Lac Repressor regulates the lac operon I. Defining the binding site
 

Summary:  defines binding site in vitro b. lac o mutants define the binding site in vivo II. Defining the DNA... " What does this suggest about the LacR?" #12;The lacOc mutants map to DNA protected in footprint" Rare... laci-d mutants are constitutive, and dominant! What molecular mechanism could explain this genetic

  

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

 

Collection: Biology and Medicine

 
10 THE GENETICS OF CAENORHABDZTZS ELEGANS Medical Research Council Laboratory of Molecular Biology,
 

Summary:  are described for the isolation, complementation and mapping of mutants of Caenorhabditis elegnns, a small free... -living nematode wmm. About 300 EMS-induced mutants affectingbehavior and morphology have been char- acterized... . Estimates of the induced mutation fre- quency of both the visible mutants and X chromosome lethals ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
11 Leaf senescence is a genetically regulated process which enables plants to relocate valuable resources from dying tissue to other parts of the plant. The notion that
 

Summary:  . The analysis of the old9 mutant reveals two novel insights in the regulation of the onset of leaf senescence... senescence. The use of eight early senescing onset of leaf death (old) mutants #12;154 indicates... age and ethylene which can be modulated by multiple genetic loci. Three of the eight mutants ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
12 Forum in immunology Live attenuated mutants of Mycobacterium tuberculosis
 

Summary:  Forum in immunology Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines... to manipulate Mycobacterium tuberculosis have led to the construction of defined mutants and to the study... of these M. tuberculosis mutants as candidate vaccines against tuberculosis are discussed. © 2005 Elsevier

  

Source: Albert Einstein College of Medicine, Department of Microbiology and Immunology, Tuberculosis Research Group

 

Collection: Biology and Medicine

 
13 Copyright 2005 by the Genetics Society of America DOI: 10.1534/genetics.104.039727
 

Summary:  of Zebrafish Insertional Mutants With Defects in Visual System Development and Function Jeffrey M. Gross,*,1... of these mutants provides unique resource through which the formation, function, or physiology of individual organ... systems can be studied. To that end, a screen for visual system mutants was performed on 250

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
14 INTRODUCTION Following gastrulation, vertebrate embryos can be
 

Summary:  are mice that are homozygous for mutations in Hoxa1 or Hoxa2. Hoxa1 mutant mice possess hindbrain... mutants possess milder defects in the organization of the hindbrain (Gavalas et al., 1997); however... that disrupts both of these linked genes. Some of the craniofacial defects observed in the double mutants were

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
15 DEVELOPMENTAL BIOLOGY 192, 274288 (1997) ARTICLE NO. DB978765
 

Summary:  of the neor gene (Figs. 1Cclasses. The double mutant analysis revealed strong syner- and 1D... and Hoxd3 revealed that these genes interact synergistically to affect the develop-that these mutant... . embryonic origins. However, analysis of mice mutant for both genes ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
16 nature neuroscience volume 5 no 4 april 2002 301 Amyotrophic lateral sclerosis (ALS), a progressive, fatal neurode-
 

Summary:  - oxide toxicity1,2. A variety of studies, including investigations of SOD1-mutant mice that develop motor... neuron disease3­6, estab- lished that mutant SOD1 causes motor neuron disease through gain of one or more... toxic properties7,8. However, the mecha- nism(s) whereby mutant SOD1 causes selective motor neuron death

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
17 Higher Order Mutation Testing Yue Jia and Mark Harman
 

Summary:  . They also reveal that many of the programs have large numbers of dumb mutants. Figure 6 shows the growth... mutants, created by the injection of a single fault. Often these first order mutants denote trivial faults... that are easily killed. Higher order mutants are created by the ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
18 Accumulation of mutants in ``aging'' bacterial colonies is due to growth under selection,
 

Summary:  revealed no increase in the frequency of other mutant types during the aging period. Classic experiments... Accumulation of mutants in ``aging'' bacterial colonies is due to growth under selection... -induced mutation. In one prominent system, mutants resistant to rifampicin (RifR; rpoB; RNA polymerase) ...

  

Source: California at Davis, University of - Center for Genetics and Development, Roth Laboratory

 

Collection: Biology and Medicine ; Biotechnology

 
19 2461DEVELOPMENT AND STEM CELLS RESEARCH ARTICLE INTRODUCTION
 

Summary:  of Tsc1/2 mutant GSC is due to hyperactivation of TORC1. One well-studied mechanism for GSC maintenance... of marbles (bam) in GSCs. In Tsc1/2 mutant GSCs, BMP signalling activity is downregulated, but bam expression... is still repressed. Moreover, Tsc1 bam double mutant GSCs could differentiate into early cystocytes

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
20 SHORT COMMUNICATION The N-terminal fragment of Arabidopsis photomorphogenic
 

Summary:  ; Figures 1c and 2a). Western analyses of those mutant seedlings revealed that N282 was indeed highly... studies with the cop1 mutant alleles, it was revealed that minor mutations, such as small deletions... mutants of COP1 into cop1 null mutant backgrounds, we show ...

  

Source: Deng, Xing-Wang - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine ; Biotechnology


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21 Synergistic interaction between Gdf1 and Nodal during anterior axis development
 

Summary:  previously been exploited to reveal Nodal-dependent pheno- types in compound mutant mice carrying mutations... +/- double mutants, while none of the 16 Gdf1+/- ;Nodal+/- ;Alk7+/- mutant embryos examined revealed any... -/- mutants had demonstrated the role of this ...

  

Source: Ibáñez, Carlos - Department of Neuroscience, Karolinska Institutet

 

Collection: Biology and Medicine

 
22 1) Molecular Biology of Plants, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands
 

Summary:  Symposium 2008, New Zealand Identification of Arabidopsis stay green mutants with a functional ethylene... senescence as a tool to screen for late senescence Arabidopsis mutants that still have a functional ethylene... -signalling pathway. Sixteen Arabidopsis onset of leaf death (old) mutants were selected that stayed green after

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
23 RESEARCH ARTICLE Dscam mutation leads to hydrocephalus and
 

Summary:  ). These results revealed the impaired motor learning ability of Dscamdel17 mutant mice. Dscamdel17 mutation leads... pathways mediating netrin-DSCAM signaling remain to be defined. Analyses of Dscamdel17 mutant mice reveal... that Dscamdel17 mutant mice exhibit severe hydrocephalus, ...

  

Source: Wu, Jane Y. - Center for Genetic Medicine & Department of Neurology, Northwestern University

 

Collection: Biology and Medicine

 
24 JOURNAL OF BACTERIOLOGY, 0021-9193/00/$04.00 0
 

Summary:  of transcriptional repressors. To understand how RosR affects these phenotypes, we mutagenized a rosR mutant... acts as a transcriptional reporter. Using a mass-mating technique, we introduced rosR into each mutant... in trans and screened for mutants that expressed different levels of -glucuronidase activity

  

Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
25 To appear in Proceedings of the 10th International Conference on Quality Software (QSIC 2010), IEEE Computer Society Press, Los Alamitos, CA (2010)
 

Summary:  middleware may introduce faults that are difficult to reveal by existing testing techniques. Our previous... for test cases relates to fault-based mutants in pervasive software. Our empirical results show... that conventional mutation operators can generate sufficient candidate mutants to support test effec- tiveness

  

Source: Hong Kong University, Department of Computer Science

 

Collection: Computer Technologies and Information Sciences

 
26 INTRODUCTION The majority of nutritional storage in cereal grains occurs in
 

Summary:  The phenotypic examination of a series of dek1 mutant alleles revealed that the gene is important for multiple... cell fate acquisition in endosperm development. Maize dek1 mutants lack aleurone cells, demonstrating... ). Late reversion of the transposon-induced dek1-PIA mutant allele allows peripheral ...

  

Source: Becraft, Philip W. - Department of Genetics, Development and Cell Biology, Iowa State University

 

Collection: Biotechnology ; Biology and Medicine

 
27 The Plant Cell, Vol. 4, 283-295, March 1992 O 1992American Society of Plant Physiologists Evidence for Nuclear Control of the Expression of the atpA
 

Summary:  B coding for the a or p subunit of the chloroplast ATP synthase. These mutants revealed the existence... mutants of Chlamydomonas reinhardtii altered in the expression of the chloroplast genes atpA or atp... subunits in various mu- tants defective in photophosphorylation. Among them were two nuclear mutants ...

  

Source: Wollman, Francis-André - nstitut de Biologie Physico-Chimique & Université Pierre-et-Marie-Curie, Paris 6

 

Collection: Biology and Medicine ; Renewable Energy

 
28 The SESAME Experience: from Assembly Languages to Declarative Models Yves Crouzet, Hlne Waeselynck, Benjamin Lussier, David Powell
 

Summary:  consists of (i) the mutant id and the list of non revealing sets, (ii) the description of the mutation... produce mutants that are based on search/replace patterns. When more sophisticated mutation operators... main modules described in Sections 2.1 and 2.2: · The Mutant Generator, which produces a database

  

Source: Powell, David - Laboratoire d'Analyse et d'Architecture des Systèmes du CNRS

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
29 INDUCTION AND SEGREGATION OF CHLOROPLAST MUTATIONS IN VEGETATIVE CELL CULTURES OF
 

Summary:  differedfrom the str-50 mutants. Only tubes revealing 11 and seven str-500 mutants among control and MTvl... - level tests were performed on all mutant colonies from cultures revealing up to 20 mutants, and on 20... control cultures, 46 re- vealed 13 or fewer str-50 ...

  

Source: Haughn, George - Department of Botany, University of British Columbia

 

Collection: Biology and Medicine

 
30 Immune and Evolutionary Approaches to Software Mutation Testing
 

Summary:  , with effectiveness measured by the number of mutant executions needed to achieve a specific mutation score. Results... their symptoms. If an adequate test set can be found that reveals the symptoms in all the faulty program versions... the process. Mutagens Input test prog, P FalseTrue Quit TrueFalse Prog Tests Create mutants ...

  

Source: Timmis, Jon - Departments of Computer Science & Electronics, University of York (UK)

 

Collection: Computer Technologies and Information Sciences

 
31 Removal of Pax6 Partially Rescues the Loss of Ventral Structures in Shh Null Mice
 

Summary:  . We have previously shown that dorsoventral patterning defects seen in Shh2/2 mutants are rescued... in Shh2/2 ;Gli32/2 compound mutants. Here we investigate if the loss of Pax6 can also ameliorate defects... seen in Shh2/2 mutants. In support of this notion, we observe that the fusion of the cerebral vesicles

  

Source: Fishell, Gordon - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
32 JOURNAL OF BACTERIOLOGY, Apr. 2007, p. 31983207 Vol. 189, No. 8 0021-9193/07/$08.00 0 doi:10.1128/JB.01833-06
 

Summary:  . PilQ Western blot analysis of these 197 mutants revealed that 138 mutants had no detectable full... mutants are nonpiliated, and thus, all pilus-dependent functions are eliminated. Mutagenesis was performed... on the middle one-third of pilQ, and mutants with colony morphologies ...

  

Source: Seifert, Hank - Department of Microbiology-Immunology, Northwestern University

 

Collection: Biology and Medicine

 
33 Copyright 2000 by the Genetics Society of America Genetic Analysis of Isometric Growth Control Mechanisms in the
 

Summary:  diminished. Double mutants for sof;lof reveal that segment length and segment number are controlled... reveals that lof mutant fins have increasingly more segments as body tants develop similarly sized... in wild-type fish. We examined the growth properties of lof and sof fin length ...

  

Source: Lehigh University, Department of Biological Sciences; Mullen, Sean P. - Department of Biological Sciences, Lehigh University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
34 Copyright 2002 by the Genetics Society of America Temperature-Sensitive Paralytic Mutants Are Enriched For Those Causing
 

Summary:  and neurodegeneration revealed by studies neurodegenerative phenotype in our screen (n 41), and of mutants such as wv... Copyright 2002 by the Genetics Society of America Temperature-Sensitive Paralytic Mutants... . The availability of a large collection of mutants exhibiting neuro- degeneration will provide ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
35 Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed
 

Summary:  therefore be an effective means to generate mutants reveal- ing a lack of test coverage -- if it were... Preservation to Behaviour Modification: Constraint-Based Mutant Generation Friedrich Steimann Lehrgebiet... expressions are evaluated. We pre- sent an approach that is knowledgeable enough to generate only ...

  

Source: Steimann, Friedrich - Fakultät für Mathematik und Informatik, FernUniversität in Hagen

 

Collection: Computer Technologies and Information Sciences

 
36 Five components of the ethylene-response pathway identified in a screen for weak ethylene-insensitive
 

Summary:  -insensitive mutants in Arabidopsis Jose M. Alonso* , Anna N. Stepanova* , Roberto Solano*§ , Ellen Wisman¶ , Simone... '' ethylene-insensitive mutants. wei1, wei2, and wei3 seedlings showed hormone insensitivity only in roots... 1, wei4, and wei5 were isolated using a positional cloning approach. The wei1 mutant harbored

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collection: Biology and Medicine

 
37 Laminin 1 and 1 Containing Laminins Are Essential for Basement Membrane Integrity in the Zebrafish Eye
 

Summary:  . Ocular defects in lamb1 and lamc1 mutants were characterized by using a combination of histology... demonstrated that zebrafish lamb1 and lamc1 mutants possess defects in two ocular basement mem- branes... and lamc1 mutants possess severe lens dysplasias that result from a compromise in lens capsule integrity

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
38 2006 Nature Publishing Group Drosophila pink1 is required for mitochondrial
 

Summary:  reveal a defect in dopaminergic neurons in pink1 mutants. However, it is important to note that Parkinson... localizes to mitochondria, and mitochondrial cristae are frag- mented in pink1 mutants. Expression of human... of pink1 mutants, demonstrating func- tional conservation between human and Drosophila ...

  

Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles; Hay, Bruce A. - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
39 A Five-residue Amino Acid Insertion Converts Cyclodextrin Glycosyltransferase into a Starch Hydrolase with a High
 

Summary:  of the three- dimensional structures revealed two large differences in the substrate binding clefts. (i... of CGTase to the extent that hydrolysis had become the main activity of the enzyme. Moreover, this mutant... ] containing 100 µg/ml ampicillin. DNA manipulations ­ Mutant CGTases were constructed as described [58], using

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
40 DEVELOPMENT 2981RESEARCH ARTICLE
 

Summary:  of the Hox5, Hox6 and Hox9 paralogous mutants at E18.5 revealed patterning defects throughout the rib cage... that whereas single mutants for Hoxa4, Hoxb4 and Hoxd4 resulted in incompletely penetrant phenotypes... . These mutants display regional anterior homeotic transformations of the posterior axial ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine


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41 Tyrosine-385 Is Critical for Acetylation of Cyclooxygenase-2 by Aspirin
 

Summary:  Phe mutant. These results reveal that Tyr-385 and, to a lesser extent Tyr- 348, are important... and several other mutants without hydroxylamine treatment. Gel electrophoretic analysis revealed... in the specific inhibition of COX-2 by other classes of non-covalent inhibitors. Mutant ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
42 INTRODUCTION Formation of the vertebrate neural plate, and generation of cell
 

Summary:  with known genes expressed in the floor plate might be revealing. Mutants with partial floor plate... anterior and posterior prechordal plate development. Our analysis of sur mutants suggests that defects... in the mid- and hindbrain. Later development of the floor plate is affected in mutant chameleon, you

  

Source: Karlstrom, Rolf O. - Department of Biology, University of Massachusetts at Amherst

 

Collection: Biology and Medicine

 
43 The Relationship Between Program Dependence and Mutation Analysis Mark Harman, Sebastian Danicic,
 

Summary:  with an input which reveals the differing behaviour. An execu­ tion which does this `kills' the mutant... . Mutants are `killed' when a test case reveals mutant behaviour which differs from that of the original... .Hierons@brunel.ac.uk Keywords: Slicing, Dependence Analysis, Test Data ...

  

Source: Harman, Mark - Department of Computer Science, King's College London

 

Collection: Computer Technologies and Information Sciences

 
44 TANMEI/EMB2757 Encodes a WD Repeat Protein Required for Embryo Development in Arabidopsis1
 

Summary:  exhibit both embryo lethality and seed- ling lethality. Analyses of mutant seedlings revealed striking... defects in both embryo and seedling development. tan mutant embryos share many characteristics... with the leafy cotyledon (lec) class of mutants in that they accumulate anthocyanin, are intolerant

  

Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
45 Development/Plasticity/Repair Independent Functions of SlitRobo Repulsion and Netrin
 

Summary:  ). For example, double mutants between slit and Netrin (the ligands) or robo and fra (the receptors) were... reported to result in phenotypes that were indistinguishable from single Netrin and fra mutants, leading... instead it is solely required to inhibit Netrin-mediated attraction. Analysis of multiple double-mutant

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
46 Selection of Antibiotic Resistance CID 2001:33 (Suppl 3) S147 S U P P L E M E N T A R T I C L E
 

Summary:  Restricting the Selection of Antibiotic-Resistant Mutants: A General Strategy Derived from Fluoroquinolone... with fluoroquinolones have led to a general method for restricting the selection of antibiotic-resistant mutants... resistance mutations for growth. That concentration has been called the "mutant prevention concentration

  

Source: Kramer, Fred - Public Health Research Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
47 Molecular Biology of the Cell Vol. 8,1481-1499, August 1997
 

Summary:  , and examined in the electron microscope. This examination of the sla2 mutants revealed a char- acteristic... observed in the sla2 mutants. Examination of mutant cells undergoing cytokinesis often revealed inclusions... mutants revealed a polar- ...

  

Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University

 

Collection: Biology and Medicine

 
48 Phenotypic Screening of Mutations in Pmr1, the Yeast Secretory Pathway Ca2
 

Summary:  Are Revealed by Phenotypic Screening of BAPTA and Mn2 Toxicity--Mutant yeast strains lacking a functional copy... Phenotypic Screening of Mutations in Pmr1, the Yeast Secretory Pathway Ca2 /Mn2 -ATPase, Reveals... in coordination of Ca2 and Mn2 ions. Mutants were expressed in low copy number in a yeast strain ...

  

Source: Rao, Rajini - Department of Physiology, Johns Hopkins University

 

Collection: Biology and Medicine

 
49 Phytochromes promote seedling light responses by inhibiting four negatively-acting
 

Summary:  , Larkin R, Nagatani A, Chory J (2001) Arabidopsis genomes uncoupled 5 (GUN5) mutant reveals... . Consistent with the gene expression patterns, the etiolated pif3 mutant accumulated a higher amount... mutant seedlings displayed constitutive photomorphogenic phe- notypes, including short hypocotyls, open

  

Source: Lee, Doheon - Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology

 

Collection: Computer Technologies and Information Sciences ; Biotechnology

 
50 Assessing Quality of Policy Properties in Verification of Access Control Policies
 

Summary:  for the original policy but does not hold for the mutant policy. In other words, the property reveals the fault... killing the mutant, revealing its fault, and increasing the mutant-killing ratio. In general, mutation... mutant policies, each with a single seeded ...

  

Source: Xie, Tao - Department of Computer Science, North Carolina State University

 

Collection: Computer Technologies and Information Sciences

 
51 Experimental Results from an Automatic Test Case Generator
 

Summary:  and immediately executed against the mutants. This Some of this work was done while the authors were... no more mutants. At this point, all test cases that killed no mutants (with current technology... whether the outputs are correct, and either add test cases to kill the remaining mutants or decide

  

Source: Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
52 Using and Improving Requirement Properties for Mutation Based Test-Case Generation
 

Summary:  -based coverage measurement to allow symbolic test-case execution and determine the mutant score of any test... . Test cases are then supposed to detect the difference between original and mutant. Originally, mutation... of the original and the mutated model can be revealed with model-checkers. Counter-examples illustrate how

  

Source: Technische Universität Graz, Institute for Software Technology

 

Collection: Computer Technologies and Information Sciences

 
53 INTRODUCTION Vertebrate Hox genes are known to play an important role in
 

Summary:  homozygous mutants. Tissue sections of Hoxb13 mutant mice did not reveal any evidence of PINs similar... urogenital sinus-derived organs revealed that samples from Hoxb13 mutant ventral prostates shared similar... -of-function mutants (Kondo et al., 1997; Podlasek et ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
54 2601RESEARCH ARTICLE INTRODUCTION
 

Summary:  spanning the 3 end of the proviral insert and exon 4 revealed that in homozygous mutants, a portion... RNAisolated from 2-cell-stage paicsMZ embryos revealed that, as expected, paicsMZ mutants lacked expression... ) (Johnstone et al., 1985; Long et al., 2006). Each of these de novo pathway ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
55 Improved Thermostability of Bacillus circulans Cyclodextrin Glycosyltransferase by the Introduction of a
 

Summary:  - sulfurigenes CGTase. Structural analysis of the B. circulans CGTase mutant revealed that this salt... thermostability of mutant 9 reveals the importance of the B- domain for the thermostability of BC251 CGTase... -rate dependent and irreversible (data not shown), this experiment revealed ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
56 Assessing Quality of Policy Properties in Verification of Access Control Policies
 

Summary:  policy but does not hold for the mutant policy. In other words, the property reveals the fault seeded... in Fig- ure 3, thus killing the mutant, revealing its fault, and increasing the mutant-killing ratio... the policy to generate various mutant policies, each with ...

  

Source: Reeves, Douglas S. - Department of Computer Science, North Carolina State University

 

Collection: Computer Technologies and Information Sciences

 
57 nature methods | VOL.5 NO.9 | SEPTEMBER 2008 | 759 news and views
 

Summary:  high-throughput protocols that use conjugation for the efficient con- struction of double mutants... are not positioned too close to each other on the chromosome. Each parental mutant is marked with an antibiotic... -resistance cassette, allowing antibiotic selection to be used to identify the desired double mutant. Both groups ...

  

Source: Gitai, Zemer - Department of Molecular Biology, Princeton University

 

Collection: Biology and Medicine

 
58 Pigment patterns: fish in stripes and
 

Summary:  an intermediate model. An important role for stem cells is revealed by mutants such as puma, which develop normal... analyses are revealing a conservation between teleosts and mammals for many aspects of pigment cell... the flank during metamorphosis, very few differentiate in puma mutants (Figure 3). ...

  

Source: Parichy, David M. - Department of Biology, University of Washington at Seattle

 

Collection: Environmental Sciences and Ecology

 
59 The Yeast VRG4 Gene Is Required for Normal Golgi Functions and Defines a New Family of Related Genes*
 

Summary:  of the staining pattern revealed striking dif- ferences in the endomembrane system of wild type and vrg4 mutant... Brook, New York 11794-5215 Sodium vanadate is an effective agent for the enrich- ment of yeast mutants... -resistant glycosylation mutants in the budding yeast, Saccharomyces cerevisiae, to ...

  

Source: Dean, Neta - Department of Biochemistry and Cell Biology, SUNY at Stony Brook

 

Collection: Biology and Medicine

 
60 Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune
 

Summary:  of plasmatocytes. Salmonella challenge revealed that in dpp mutants the misregu- lation of this cascade also... Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune... -shaped (Ush) in hematopoietic cells. Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to ...

  

Source: Hall, Sharon J. - School of Life Sciences, Arizona State University

 

Collection: Environmental Sciences and Ecology


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61 AN EVALUATION OF MUTATION OPERATORS FOR EQUIVALENT MUTANTS
 

Summary:  AN EVALUATION OF MUTATION OPERATORS FOR EQUIVALENT MUTANTS By Maryam Umar Supervised By Mark Harman... Mark Harman with the proposition to work on the problem of equivalent mutants. I was told that that I... mutation operators are used to create these faulty programs. These programs are called mutants. The ...

  

Source: Harman, Mark - Department of Computer Science, King's College London; Offutt, Jeff - Department of Computer Science, George Washington University

 

Collection: Computer Technologies and Information Sciences

 
62 Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic
 

Summary:  mutants. Previous studies revealed that LmrP recognizes its lipophilic, cationic substrates within... indeed revealed a relation between the transport rate and the amount of TMA-DPH associated with the inner... and the transport activities of the mutant proteins were measured as the excretion of the cationic ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
63 Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens
 

Summary:  yet to be reported. We show that zebrafish mutants in uhrf1 and dnmt1 have defects in lens development... mutant backgrounds. This is correlated with a wave of apoptosis in the epithelial layer, which... conditional knockout studies have revealed an essential requirement for Dnmt1 in hematopoiesis (Broske et al

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
64 Introduction In recent years, many of the genes that are involved in early
 

Summary:  . Pattern of Sox9 expression in control (C) and double mutant (D) section, as revealed by radioactive... are properly positioned at the ends of the condensations. Mice with three mutant alleles further revealed... . For example, in mice mutant for Hoxa10, Hoxc10 and Hoxd10, or ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
65 Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1
 

Summary:  mutants in TZM-bl and PBMC revealed interesting features that are best visualized in supplementary figure... Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1 Javier P... the frequency of mutants in a viral population. As human immunodeficiency virus type 1 (HIV-1) ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
66 Homeostasis of Synaptic Transmission in Drosophila with Genetically Altered Nerve Terminal Morphology
 

Summary:  varicosities in the mutant. Ultrastructural analysis reveals that mutant nerve terminals have bigger synapses... in synaptic complex- ity provide for more transmitter release at mutant varicosities. These results show... et al., 1990; Zhong et al., 1992; Wang et al., 1994). However, because these ...

  

Source: Stewart, Bryan - Department of Biology, University of Toronto at Mississauga

 

Collection: Environmental Sciences and Ecology

 
67 OPTIMALITY CRITERIA FOR THE PREDICTION OF METABOLIC FLUXES IN YEAST MUTANTS
 

Summary:  . Comparison of flux predictions to complementary experimentally measured fluxes revealed that for all mutants... 123 OPTIMALITY CRITERIA FOR THE PREDICTION OF METABOLIC FLUXES IN YEAST MUTANTS EVAN S. SNITKIN1... deletion mutants across a variety of possible objective functions. We find that the specific ...

  

Source: Segrè, Daniel - Departments of Biology & Biomedical Engineering, Boston University

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
68 Mutation analysis for security tests qualification Tejeddine Mouelhi,
 

Summary:  to be completed with others, the first results reveal that we can limit the types and number of generated mutants... cases aiming at testing a security policy. The objective is to make test cases efficient to reveal... on the implementation and produce a verdict that reveals the presence or absence of a ...

  

Source: Jézéquel, Jean-Marc - Triskell Project & IRISA, Université de Rennes

 

Collection: Computer Technologies and Information Sciences

 
69 Copyright 2002 by the Genetics Society of America Maximal Power Tests for Detecting Defects in Meiotic Recombination
 

Summary:  linked, the mutant and wild type or strain is recombination deficient. Identifying gene pro- will both... bers of gametes must be tested to establish any difference. testing appropriate mutants... recombination requires as- the putative mutant. saying for a defect in meiotic recombination. The problem

  

Source: Adler, Fred - Department of Mathematics, University of Utah

 

Collection: Environmental Sciences and Ecology

 
70 Molecular Biology of the Cell Vol. 21, 40574060, December 1, 2010
 

Summary:  to be revealed based on the localization patterns of vacuolar proteins in yeast mutants with vacuolar protein... . This analysis identified mutants in five additional complementation groups and revealed previ- ously undetected... ., Muller, S., Hanisch, F. G., and Hulskamp, M. (2006). The Arabidopsis elch ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
71 KNOCK-OUT OF THE MG PROTOPORPHYRIN IX METHYLTRANSFERASE GENE IN ARABIDOPSIS: EFFECTS ON
 

Summary:  of the mutant to carry out plastid-to-nucleus signaling. The results reveal a high level of repression... protoporphyrin IX methyltransferase (CHLM) knock-out mutant in Arabidopsis in which the mutation induces... in the chlm mutant provides an independent indication that Mg protoporphyrin IX is a negative ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
72 Vitamer Levels, Stress Response, Enzyme Activity, and Gene Regulation of Arabidopsis Lines Mutant in the
 

Summary:  Vitamer Levels, Stress Response, Enzyme Activity, and Gene Regulation of Arabidopsis Lines Mutant... of the vitamin B6 pathway genes in Arabidopsis (Arabidopsis thaliana) plants mutant in PDX3 and SOS4. sos4 mutant... as hypersensitivity to sucrose in addition to the previously noted NaCl sensitivity. This ...

  

Source: Daub, Margaret - Center for Integrated Fungal Research & Department of Plant Biology, North Carolina State University

 

Collection: Biotechnology ; Biology and Medicine

 
73 JOURNAL OF VIROLOGY, Jan. 1992, p. 505-511 0022-538X/92/010505-07$02.00/0
 

Summary:  - ysis of these mutants in collaboration with Schlegel and colleagues revealed that the glutamine... growth transformation of cultured rodent fibroblast cell lines. Previous studies revealed that efficient... otherwise defective mutants containing random hydrophobic sequences. However, a class of ...

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
74 Original Paper Dev Neurosci 2002;24:262271
 

Summary:  and mutant 30-day-old animals. The autora- diographs reveal increased GluR2 expres- sion throughout... as a model of neuronal degeneration. Mutant sHW rats display a number of developmental abnormali- ties... and hippocam- pal Fos protein expression in these animals indicated that mutants develop paroxysmal ...

  

Source: Cohen, Randy W. - Department of Biology, California State University, Northridge

 

Collection: Biology and Medicine

 
75 Appl. Magn. Reson. 21, 1#XXX (2001) High-Field EPR-Detected Shifts of Magnetic Tensor
 

Summary:  illumination the spectrum of the single mutant reveals gxx and Azz tensor com- ponent shifts which resemble... of molecular oxygen reveal that the nitroxide in the triple mutant is not accessible for oxygen... mutant does not reveal any changes of the gxx and Azz ...

  

Source: Steinhoff, Heinz-Jürgen - Fachbereich Physik, Universität Osnabrück

 

Collection: Biology and Medicine ; Physics

 
76 ORIGINAL PAPER Minou Nowrousian Carol Ringelberg Jay C. Dunlap
 

Summary:  in melanin biosynthesis and a lectin-like protein. Analysis of gene expression in double mutants revealed... analyses with RNAs from 4- to 5-day-old mycelia from mutants pro11 and pro22 also revealed up- regulation... by complementation of the sterile mutants pro1, pro11 and pro22. To ...

  

Source: Kück, Ulrich - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
77 Mitochondria Provide the Main Source of Cytosolic ATP for Activation of Outward-rectifying K Channels in Mesophyll
 

Summary:  activity during photosynthesis are needed. Our data revealed that the OsCHLH rice mutant plants have... Channels in Mesophyll Protoplast of Chlorophyll-deficient Mutant Rice (OsCHLH) Seedlings* Received... mutant, which lacks chlorophyll in the thy- lakoids, was isolated by T-DNA gene trapping (Jung, K

  

Source: An, Gynheung - Department of Life Science, Pohang University of Science and Technology

 

Collection: Biotechnology ; Biology and Medicine

 
78 NEUROSYSTEMS Lack of kainic acid-induced gamma oscillations predicts
 

Summary:  ). However, the LFP power spectrogram of mutant area CA1 (Fig. 5F) revealed a significantly lower magnitude... injection, and was unchanged 4 weeks after treatment. In the mutants, regional analysis revealed a severe... deletion was confined to CA3 pyramidal cells. Mutants showed reduced ...

  

Source: McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health

 

Collection: Biology and Medicine

 
79 40 hexameric helicase The roles of the residues on the channel {beta}-hairpin and loop structures of simian virus
 

Summary:  binding assays with different mutants revealed a common phenomenon: most of the mutants that retained... of these residues in helicase function, we obtained a set of mutants and examined various activities, including... Hex for strand separation. The crystal structures of LTag at various nucleotide-bound ...

  

Source: Chen, Xiaojiang - Departments of Biological Sciences & Chemistry, University of Southern California

 

Collection: Biology and Medicine ; Chemistry

 
80 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  double mutants with muta- tions at both positions 33 and 36. These experiments revealed an absolute... mutants containing all possible substitutions at position 33, as well as several double mutants containing... substitutions at aspartic acid 33 and at glutamic acid 36, and we examined the ability of these ...

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University; Klein, Ophir - Departments of Orofacial Sciences & Pediatrics, University of California at San Francisco; Smith, Steven O.- Department of Biochemistry and Cell Biology, SUNY at Stony Brook

 

Collection: Biology and Medicine


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81 Fitness correlates with the extent of cheating in a bacterium N. JIRICNY*, S. P. DIGGLE , S. A. WEST*, B. A. EVANS, G. BALLANTYNE,
 

Summary:  . 2008. Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae... to mutant strains that do not perform, or invest less in, that trait. If these mutant strains increase... experiments using mutant strains, termed `cheats', which exploit the coop- ...

  

Source: West, Stuart - School of Biological Sciences, University of Edinburgh

 

Collection: Environmental Sciences and Ecology

 
82 Biochem. J. (2001) 357, 211216 (Printed in Great Britain) 211 Characterization of the cyanobacterial ycf37: mutation decreases the
 

Summary:  a cyanobacterial mutant that lacks the putative homologue of ycf37, the chloroplast open reading frame 37, which... revealed the presence of several conserved chloroplast open reading frames (ORFs), or ycf genes, whose... of ycf functions [3,4]. Most of the generated chloroplast mutants are impaired in photosynthetic

  

Source: Kück, Ulrich - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
83 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 499504, January 1999
 

Summary:  Proc. Natl. Acad. Sci. USA Vol. 96, pp. 499­504, January 1999 Cell Biology A Gs mutant designed... a functionally analogous dominant negative G mutation. Here we describe a mutant subunit designed to inhibit... this mutant, we introduced into the subunit ( s) of Gs three separate mutations chosen because they impair

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
84 Sugar and hormone connections Patricia Leo n1
 

Summary:  pathways. Sugar-signalling mutants reveal the hormone connections Recent genetic and molecular studies... in Table 1, the characterization of several sugar mutants (such as gin6, isi3, sis5 and sun6) has revealed... . (2000) Analysis of Arabidopsis glucose insensitive mutants, gin5 and ...

  

Source: Sheen, Jen - Department of Genetics, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
85 Journal of Theoretical Biology 236 (2005) 335348 Spatial invasion by a mutant pathogen
 

Summary:  Journal of Theoretical Biology 236 (2005) 335­348 Spatial invasion by a mutant pathogen Wei Wei... dies out due to a subcritical density of susceptibles. If a mutant pathogen, having some advantage over... . Mutants that arise closer to the infection wavefront have access to more susceptible hosts and thus

  

Source: Krone, Steve - Department of Mathematics, University of Idaho

 

Collection: Mathematics

 
86 Growth control and polarization Department of Plant Biology, University of Georgia, Athens, GA, USA
 

Summary:  that complemented the ahbB mutant showed that it encodes a novel protein. Database searches revealed ahb... to polarity using A. nidulans polarity mutants with defects in germ tube emergence (swo mutants) or branching... (ahb mutants) will also be discussed. Keywords branching, polarity ...

  

Source: Momany, Michelle - Department of Plant Biology, University of Georgia

 

Collection: Environmental Sciences and Ecology

 
87 INTRODUCTION The int-2 gene (also designated Fgf-3) is a member of the
 

Summary:  examination of serial sections from this and other matched pairs of control and mutant embryos revealed... embryo taken posterior to that in Fig. 7C. The comparable section from a mutant embryo does not reveal... mutant embryonic inner ears has not revealed any ...

  

Source: Capecchi, Mario R. - Department of Biology, University of Utah

 

Collection: Biology and Medicine

 
88 Dr. Lakshmi Goyal Cell Editorial Office
 

Summary:  was the identity of the three strains revealed to the investigator who performed the experiment. Including the data... with fresh cultures of cells. Each of these experiments revealed that Pop1p stability is lower in ubp12... and csn5 mutants as claimed before. In the revised Fig. 6C, we are now showing the data from the latest

  

Source: Wolf, Dieter A.- Burnham Institute for Medical Research

 

Collection: Biology and Medicine

 
89 The Vacuolar-ATPase Complex Regulates Retinoblast Proliferation and Survival, Photoreceptor
 

Summary:  in the atp6ap1 gene. Cloning and sequencing of the atp6ap1 locus in a82 mutants revealed that a82 mutants... . This study was conducted to characterize ocular defects in five zebrafish mutants in which core components... as a sixth mutant in which a v-ATPase associated protein (atp6ap1) ...

  

Source: Gross, Jeff - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
90 Site-Specific Mutations of Conserved Residues in the Phosphate-Binding Loop of the Arabidopsis UMP/CMP
 

Summary:  to be purified. Kinetic studies on the other mutants, when compared to studies on the wild-type enzyme, revealed... mutated by site-directed mutagenesis to generate seven mutant enzymes: G21A, G22A, G24A, G26A, K27R, K27M... , and K27E. The G21A and G26A mutants were degraded dur- ing the purification phase ...

  

Source: Thornburg, Robert - Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University

 

Collection: Biology and Medicine

 
91 Mutation Analysis for the Evaluation of Functional Fault Models Qiushuang Zhang and Ian Harris
 

Summary:  analysis ter- minology, a mutant is a version of a soft- ware program which differs from the original... program to generate a mutant. A set of mutation operators describes all ex- pected design errors... in the program. Types Good Machine Mutant AOR x :¥ x ¡ y x :¥ x ¨ y LOR x and y x or y ROR rst ¥ true rst©¥ true

  

Source: Harris, Ian G. - Department of Electrical and Computer Engineering, University of California, Irvine

 

Collection: Computer Technologies and Information Sciences

 
92 Copyright 2009 by the Genetics Society of America DOI: 10.1534/genetics.109.106880
 

Summary:  and canonical Rac-signaling pathway mutants have increased neuromuscular excitability, as revealed... mutants, except for hypomorphic mig-15(rh148) mutants, had misaccumulated syn- aptic vesicles, as revealed... assays with Rac GTPase mutant backgrounds ...

  

Source: Caldwell, Guy - Department of Biological Sciences, University of Alabama in Tuscaloosa

 

Collection: Biology and Medicine

 
93 Loss-of-Function Mutations in the Arabidopsis Heterotrimeric G-protein a Subunit Enhance the Developmental Defects of Brassinosteroid
 

Summary:  the Developmental Defects of Brassinosteroid Signaling and Biosynthesis Mutants Yajun Gao 1, 2 , Shucai Wang 1... the developmental defects of bri1-5, a weak allele of a BR receptor mutant, and det2-1, a BR-deficient mutant... in Arabidopsis. gpa1-2 bri1-5 and gpa1-4 det2-1 double mutants had shorter ...

  

Source: Whitton, Jeannette - Department of Botany, University of British Columbia

 

Collection: Environmental Sciences and Ecology

 
94 The GCR2 Gene Family Is Not Required for ABA Control of Seed Germination and Early Seedling Development in
 

Summary:  . A central question in this controversy is whether gcr2 mutants are insensitive to ABA, because gcr2 mutants... combinations of mutations in each member of the GCR2 gene family. We found that all double mutants, including... gcr2 gcl1, gcr2 gcl2, gcl1 gcl2, as well as the gcr2 gcl1 gcl2 triple mutant ...

  

Source: Whitton, Jeannette - Department of Botany, University of British Columbia

 

Collection: Environmental Sciences and Ecology

 
95 RESEARCH ARTICLE Open Access Regulation of endocytic trafficking of transferrin
 

Summary:  by optineurin and its impairment by a glaucoma-associated mutant Ananthamurthy Nagabhushana1 , Madhavi L... analyzed the role of optineurin in endocytic recycling and the effect of E50K mutant on this process... . This impaired trafficking by the E50K mutant requires the function of its ubiquitin-binding domain. Compared

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
96 Function of Extracellular Loop 2 in Rhodopsin: Glutamic Acid 181 Modulates Stability and Absorption Wavelength of Metarhodopsin II
 

Summary:  a set of site-directed mutants. Sixteen of the 19 single-site mutants expressed and bound 11-cis... -retinal to form pigments. The max value of mutant pigment E181Q showed a significant spectral red shift to 508 nm... of the mutant pigments in the dark. Thus, Glu181 does not contribute significantly to ...

  

Source: Chang, Belinda - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collection: Biology and Medicine

 
97 Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.107.073635
 

Summary:  in elevated P53-dependent apoptosis, rough eyes, and increased genomic instability. Reducing Pola in mutants... mutants lacking the ATR ortholog Mec1 have elevated rates of gross chromosomal rearrangements (Cobb et al... . 2003), and decreasing expression of the catalytic subunit of Pola by 90% in a mec1 mutant results in in

  

Source: Sekelsky, Jeff - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
98 Autophosphorylation at Thr286 Calcium-Calmodulin Kinase II
 

Summary:  stimulation protocols revealed similar LTP impairments in the CaMKIIT286A-129B6F2 mutants (Fig. 2C). These LTP... M-dependent activity. The mutant mice had no N-methyl-D-aspartate receptor­dependent LTP in the hippocampal CA1 area... mutants analyzed were F2 mice from a cross between the chimeras ...

  

Source: Silva, Alcino - Department of Neurobiology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
99 Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis
 

Summary:  in the puma mutant phenotype depended on interactions between growth conditions and light levels revealed con... assess pigment pattern development in puma mutants, we Fig. 4. Quantitative analyses reveal failure... of melanophore distributions reveals partial pigment pattern regulation ...

  

Source: Parichy, David M. - Department of Biology, University of Washington at Seattle

 

Collection: Environmental Sciences and Ecology

 
100 Iron Source Preference and Regulation of Iron Uptake in Cryptococcus neoformans
 

Summary:  in YPD medium at 308C. These tests also revealed that the mutants did not differ from wild type... ;29 (data not shown) thus revealing that the cft1 mutant was also attenuated for virulence... . cerevisiae and C. albicans. Our analysis of mutants defective in CFT1, CFT2 or both genes ...

  

Source: Kosman, Daniel J.- Department of Biochemistry, State University of New York at Buffalo

 

Collection: Biology and Medicine ; Chemistry


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