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Sample search results for: aav-mediated intramuscular delivery

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1 Systemic but Not Intraocular Epo Gene Transfer Protects the Retina from Light-and
 

Summary:  the rescue effects to those produced by intramuscular delivery. RESULTS AND DISCUSSION Assessment... and Characterization of Epo Expression Following AAV-Mediated Gene Transfer in Albino Rats and rds and rd10 Mice We... in AAV- transduced muscle versus retina. Morphological and Functional Photoreceptor Rescue Following ...

  

Source: Sandini, Giulio - Dipartimento di Informatica Sistemistica e Telematica, Università degli Studi di Genova

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
2 Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 466 Progress in the therapeutic efficacy of intrastriatal rAAV-mediated l-dopa delivery... of intrastriatal rAAV-mediated L-dopa delivery. Until recently, the apomorphine-induced rotational behavior... model enabled the testing of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
3 Progress in Direct Striatal Delivery of L-Dopa via Gene Therapy for Treatment of Parkinson's Disease Using Recombinant
 

Summary:  . Therefore, it is important to test rAAV-mediated striatal L-dopa delivery in an animal model that is clearly... are not practical. More- 49rAAV-MEDIATED L-DOPA GENE THERAPY FOR PD #12;over, peripheral continuous administration... -dopa is available to all dopaminergic regions of the brain. The Advantage of Site-Specific ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
4 Recombinant Adeno-associated Viral Vector-Mediated Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Protects
 

Summary:  . The onset of rAAV-mediated GDNF transgene expression near the substantia nigra was determined to begin... - course of rAAV-mediated GDNF expression. Previous studies using rAAV encoding different transgenes... different tissues has suggested that rAAV-mediated transgene expression is detectable after some delay

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
5 HUMAN GENE THERAPY 16:781791 (July 2005) Mary Ann Liebert, Inc.
 

Summary:  intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. Proc. Natl. Acad. Sci. U.S.A. 99, 4708... in parkinsonian rats (Carlsson et al., 2005). rAAV-mediated glial cell line-derived neurotrophic factor (GDNF... for at least 6 months (Kirik et al., 1998) and in marmosets rAAV-mediated GDNF was ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
6 HUMAN GENE THERAPY 19:7181 (January 2008) Mary Ann Liebert, Inc.
 

Summary:  ., 2003). The intramuscular delivery method required 4 1010 viral particles and a minimum of three... ., 1997). Anterograde delivery can potentially include UMNs in the treatment whereas intramuscular... 301, 839­842. KIRIK, D., ROSENBLAD, C., BJORKLUND, A., and MANDEL, R.J. (2000). Long-term ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
7 GENE THERAPY AAV-mediated factor IX gene transfer to skeletal muscle in patients with
 

Summary:  GENE THERAPY AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe... studies, we demonstrated that either skeletal muscle or liver could serve as a target tissue for AAV-mediated... . This requirement rests on 3 distinct features of AAV-mediated gene transfer and F.IX expression in skeletal muscle

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
8 REVIEW ARTICLE Adeno-Associated Virus Vectors and Hematology
 

Summary:  in vivo delivery of AAV vectors in mice. Herzog et al72 delivered an intramuscular injection of 2 1011... % of hepatocytes were positive for AAV-mediated gene expression as determined by RNA in situ hybridization... have shown the therapeutic value of AAV-mediated gene transfer in murine and/or canine hemo- ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
9 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.15.69696976.2001
 

Summary:  that extrachromosomal, not integrated, genomes are the major form of rAAV in the liver and are the primary source of rAAV-mediated... uncertainties as to whether rAAV-mediated hepatic gene expression can persist lifelong after a single vector... . 4. rAAV-mediated gene expression in partially hepatecto- mized mice. The figure ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
10 ORAL PRESENTATION Open Access Immunosuppressive role of fibrinogen-like
 

Summary:  antibodies [3] and can be mimicked by FGL2 protein alone. Moreover, AAV-mediated FGL2 overexpression in rat... associated virus (AAVFGL2) are intramuscularly or intravenously injected in recipients 30 days before

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
11 MOLECULAR THERAPY Vol. 4, No. 6, December 2001 Copyright The American Society of Gene Therapy
 

Summary:  cells. To evaluate the safety of in vivo recombinant adeno-asso- ciated virus (rAAV) mediated gene... early disease targets for AAV- mediated gene transfer, hemophilia and muscular dystro- phy, affect males... . The data thus far suggest that the risk of germline transmission of vector sequences in the ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
12 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 18 no. 5, 873880 may 2010 873
 

Summary:  , Intracranial AAV-mediated Gene Therapy, or Both in the Mouse Model of MPS IIIB Coy D Heldermon1,2 , Kevin K... , combining CNS-directed, AAV-mediated gene therapy with BMT resulted in dramatic synergy and signifi- cant... performance, we observed little or no improvement in histology. CNS-directed AAV-mediated therapy

  

Source: Orrock, John - Department of Zoology, University of Wisconsin at Madison

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
13 original article 2114 www.moleculartherapy.org vol.15no.12,21142123dec.2007
 

Summary:  reflect the effectiveness of recombinant adeno-associated virus (rAAV)-mediated gene delivery... to assessing the biology of rAAV-mediated transduction for three serotypes, we characterized the bioelectric... not be the best model for preclinical testing of rAAV-mediated gene therapy to the airway in humans. ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
14 Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Gene therapy for hemophilia
 

Summary:  -associated virus serotype 2 vector: global distribution and broad dispersion of AAV- mediated transgene expression... , Hutchison S, et al. AAV-mediated factor IX gene transfer to skeletal muscle in patients with severe... to receptors on the outside of cells and facilitate efficient delivery, and are ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
15 ADVANCES IN VIRUS RESEARCH, VOL. 55 ADENO-ASSOCIATED VIRUS VECTOR-MEDIATED
 

Summary:  . These data demon- strate that local rAAV-mediated gene delivery in solid tissues such as muscle... that intramuscular and intravenous delivery does not result in a cell- mediated immune response, but does produce... will produce different expression patterns. Colocalization studies have demonstrated that ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
16 Evaluation of Pathological Manifestations of Disease in Mucopolysaccharidosis VII Mice after Neonatal
 

Summary:  with the effect of AAV-mediated gene therapy in mice [20] and with echocardiographic improvements in RV... . Similar improvements were observed in MPS VII mice after systemic neonatal AAV-mediated gene therapy [20... is a reasonable target. This is consistent with results obtained after AAV-mediated gene therapy in mice, in which

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
17 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Neonatal gene transfer with a retroviral vector results in tolerance to human
 

Summary:  animals after IV injection of an adenoviral vector32 and in 1 of 5 animals after liver-directed, AAV-mediated... , Armstrong E, et al. Risk and prevention of anti-factor IX formation in AAV- mediated gene transfer... transfer to adult immunocompetent mice. Antibodies developed after intramuscular (IM) ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
18 64 NATURE MEDICINE VOLUME 5 NUMBER 1 JANUARY 1999 Hemophilia is an X-linked recessive bleeding disorder that
 

Summary:  times. With 16­25% or more activity, the bleeding times were in the normal range, indicating that AAV-mediated... procedures. The studies here demonstrate that rAAV-mediated gene transfer of the hFIX cDNA can correct... of hemophilia. Although intramuscular expression of factor IX may be useful for treating hemophilia B (refs. ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
19 Long-term Skeletal Muscle Protection After Gene Transfer in a Mouse Model of LGMD-2D
 

Summary:  . The ability of recombinant AAV­mediated gene delivery to restore normal muscle mechanical properties in sgca... be prevented in a mouse model of LGMD-2D using an AAV-mediated gene delivery technique. We found... ). Here we describe muscle-specific gene delivery of the human sgca gene ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
20 Mol Ther . Author manuscript Functional cone rescue by RdCVF protein in a dominant model of retinitis
 

Summary:  rhodopsin expression in vivo by AAV mediated siRNA delivery . Vision Res . 47 : 1202 - 1208 37... , Maclaren RE , Duran Y , Balaggan KS , MacNeil A , Schlichtenbrede FC . 2006 ; In contrast to AAV-mediated... Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics


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21 Progress and prospects: techniques for site-directed mutagenesis in animal models
 

Summary:  - quencies of AAV-mediated homologous recombination-- up to 0.1% in human cell lines--even in the absence... by conventional targeting approaches with linear DNA fragments. The mechanism of AAV-mediated homologous recombina... and adenoviral vectors have not worked well for applications of gene targeting. rAAV-mediated gene ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
22 HUMAN GENE THERAPY 16:299306 (March 2005) Mary Ann Liebert, Inc.
 

Summary:  two times higher than the TV group. This confirmed that HA or PV delivery route is more efficient at rAAV-mediated... with selective liver lobes infusion pro- cedure (SE group). In order to obtain AAV-mediated liver trans- duction... confirmed that HA infusion is equally effective for rAAV-mediated gene ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
23 Current Gene Therapy, 2009, 9, 375-388 375 1566-5232/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  such that the peptide contained signalling sequences from immu- noglobulin or NGF, lenti-viral or rAAV mediated over... -loss in aged leptin-resistant obese rats than hypothalamic GDNF over- expression [101]. We found that nigral rAAV-mediated... some doubt in the field about trophic factor delivery for the ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
24 Introduction Cystic fibrosis (CF) is the most common inherited dis-
 

Summary:  evaluating the effect of proteasome inhibitors on AAV-mediated gene transfer in lung, liver, and muscle... . To determine the effect of the proteasome inhibitor on AAV-mediated gene transfer in mouse lung, 6-week... on AAV-mediated gene transfer in liver, 6-week-old C57BL/6 mice were anesthetized with ketamine /xylazine

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
25 Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display
 

Summary:  Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System... in the nervous system. Key Words: AAV, capsid, serotype, gene delivery, nervous system, brain, spinal cord

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
26 original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285
 

Summary:  in the lung fol- lowing injury and normal cellular turnover.15 Although the effi- ciency of rAAV-mediated gene... AAV is capable of transducing resident lung stem/progenitor cells. Furthermore, it is unclear whether rAAV-mediated... recombination. rAAV-mediated functional expression of cre in the adult mouse lung To investigate ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
27 Current Gene Therapy, 2007, 7, 347-360 347 1566-5232/07 $50.00+.00 2007 Bentham Science Publishers Ltd.
 

Summary:  neutralizing antibodies can affect intrac- erebral rAAV-mediated transduction. Moreover, when rAAV2 pre... careful analysis of rAAV-mediated immune responses in the brain, similar to the studies that have been... and promising tool for the treatment for neurological disorders. Viral vectors are ideal gene delivery vehicles

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
28 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  strategies for improving rAAV-mediated gene transfer in vivo. Recombinant adeno-associated virus (r... -stranded (ss) rAAV genomes. Following intraportal administration of vector into animals, rAAV-mediated gene

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
29 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 17 no. 11, 18571867 nov. 2009 1857
 

Summary:  & Cell Therapy Single rAAV-mediated Regulated Striatal GDNF expression in vivo for extended periods... nov. 2009 1859 © The American Society of Gene & Cell Therapy Single rAAV-mediated Regulated Striatal... no. 11 nov. 2009 © The American Society of Gene & Cell Therapy Single rAAV-mediated Regulated

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
30 MOLECULAR AND CELLULAR BIOLOGY, May 2003, p. 35583565 Vol. 23, No. 10 0270-7306/03/$08.00 0 DOI: 10.1128/MCB.23.10.35583565.2003
 

Summary:  stimulates the frequency of rAAV-mediated gene targeting by over 100-fold, suggesting that the mechanism of rAAV-mediated... by activating the homology-directed repair of the DSB. To examine whether rAAV-mediated gene targeting can... targeting by a DSB is evidence that one mechanism of rAAV-mediated gene ...

  

Source: Baltimore, David - Division of Biology, California Institute of Technology

 

Collection: Biotechnology ; Biology and Medicine

 
31 ISSN: 1524-4539 Copyright 2009 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online
 

Summary:  6 shows that AAV-mediated Fluc expression was significantly higher compared to MC and PL after first... of AAV in the contralateral leg at 4 weeks after primary injection resulted in no AAV-mediated signal... response.2 Nonviral gene delivery strategies are usually based on plas- mid DNA carrying the gene

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
32 Nerve Growth Factor Expressed in the Medial Septum Following in Vivo Gene Delivery Using a Recombinant Adeno-Associated Viral Vector
 

Summary:  prior to a FF lesion in rats. This rAAV-mediated NGF delivery was shown to significantly attenuate... delivery method for the treatment of AD. The present study demonstrates the bioactivity of NGF following rAAV-mediated... months (18). rAAV-mediated transgene expression for up to 1 year ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
33 Functional cone rescue by RdCVF protein in a dominant model of retinitis , Saddek Mohand-Said
 

Summary:  ). Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery. Vision Res 47, 1202-1208. 37... , KS, MacNeil, A, Schlichtenbrede, FC et al. (2006). In contrast to AAV-mediated Cntf expression, AAV-mediated... of RdCVF to the point of evaluation in a clinical trial. ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
34 JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0
 

Summary:  confirmed previous successes in rAAV-mediated gene transfer to muscle tissue (5, 10, 15, 19, 34... in the application of rAAV, the mechanisms of in vivo rAAV- mediated transduction and persistence of transgene... delivery systems with increased efficiency. Adeno-associated virus type 2 (AAV) contains a ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
35 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Neonatal or hepatocyte growth factorpotentiated adult gene therapy with a
 

Summary:  in hemophilia B dogs by AAV- mediated gene therapy in liver. Mol Ther. 2000;1: 154-158. 24. Mount JD, Herzog RW... result- ing from factor IX (FIX) deficiency that might be treated with gene therapy. Neo- natal delivery... , intramuscular injection of AAV vectors resulted in 3% to 7% of normal5,20,21 or 1000% ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
36 NATURE MEDICINE VOLUME 6 NUMBER 5 MAY 2000 595 NEW TECHNOLOGY
 

Summary:  with this vector system. One well-known example is rAAV-mediated gene therapy for cystic fibrosis. For this... AAV vectors. Based on this, we have developed a new approach to en- hance the efficiency of rAAV-mediated gene... circularized molecule. Fig. 3 Intermolecular cis activation in- creases rAAV-mediated gene transfer in fi

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
37 Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic
 

Summary:  of receptors in AAV-mediated gene transfer was assessed by competition assays. Finally, we examined the ability... surface receptors other than HSPG will be critical to the advancement of AAV- mediated gene therapy... ]. In an effort to determine whether AAV-mediated HSVtk gene expression in conjunction with ...

  

Source: Hemminki, Akseli - Department of Biosciences, University of Helsinki

 

Collection: Biology and Medicine

 
38 Free DNA Ends Are Essential for Concatemerization of Synthetic Double-Stranded Adeno-Associated
 

Summary:  concerns exist as to how far our system repre- sents rAAV- mediated gene delivery in vivo, these findings... ., Storm, T. A., and Kay, M. A. (2000). Increasing the size of rAAV-mediated expression cassettes in vivo... vehicle for delivery of transgenes to various tissues because it can ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
39 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  cells. Curr Top Microbiol Immunol 158: 97­129. 2. Hildinger, M and Auricchio, A (2004). Advances in AAV-mediated... delivery to the nonhuman primate striatum and therefore better candidates for therapeutic applications... to the central nervous system in a site-specific manner. Among the many different viral delivery systems

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
40 Neurobiology of Aging 27 (2006) 459470 Hypothalamic rAAV-mediated GDNF gene delivery
 

Summary:  Neurobiology of Aging 27 (2006) 459­470 Hypothalamic rAAV-mediated GDNF gene delivery ameliorates... via its effects on dopaminergic neurons in the hypothalamus. Continuous rAAV-mediated GDNF expression... (BAT) were measured. We report here the novel finding that rAAV-mediated ectopic hypothalamic GDNF

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine


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41 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  of vector delivered was also low. Thus, delivery of AAV as a CaPi coprecipitate mark- edly enhanced AAV-mediated... - creased 100-fold. Thus, delivering AAV as a CaPi coprecipitate markedly enhanced AAV-mediated gene... gene transfer by binding virus to the cell surface, we hypothesized that AAV-mediated gene ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
42 Discovery Medicine, Volume 9, number 46, Pages 204-211, March 2010 Abstract: Given improvements in viral vector design,
 

Summary:  ; Mandel et al., 2006). Furthermore, rAAV mediated over-expression of glutamic acid decarboxylase (GAD... in the Str. Concomitantly, a thinning of the MFB occurs. B. rAAV-mediated nigrostriatal GDNF over... . rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
43 * Corresponding author. Tel.: 1-765-494-7944; fax: 1-765-494-4080. E-mail address: peppas@ecn.purdue.edu (N.A. Peppas).
 

Summary:  by intramuscular injection, thus, limiting their use as therapeutic agents. 3. Controlled delivery systems... for calcitonin Currently, the most common delivery route to admin- ister sCT is through intramuscular... @ecn.purdue.edu (N.A. Peppas). Biomaterials 21 (2000) 1191}1196 Review Transmucosal ...

  

Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin

 

Collection: Biology and Medicine ; Materials Science

 
44 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  ://www.elsevier.com/copyright #12;Author's personal copy rAAV-mediated nigral human parkin over-expression partially ameliorates... but forelimb akinesia as assessed by the stepping test was unaffected. rAAV-mediated human parkin was expressed... in either forehand or backhand stepping (Figs. 1E, F). rAAV-mediated transduction ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
45 HUMAN GENE THERAPY 10:911 922 (April 10, 1999) Mary Ann Liebert, Inc.
 

Summary:  HUMAN GENE THERAPY 10:911± 922 (April 10, 1999) Mary Ann Liebert, Inc. Intramuscular Injection... induced by intramuscularly administered Ad.CMV.HGF, 8% of hepatocytes were transduced. We conclude... that intramuscular injection of Ad.CMV.HGF is a safe and effective way to induce transient systemic expression of HGF

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
46 Ribozyme rescue of photoreceptor cells in P23H transgenic rats: Long-term survival and
 

Summary:  ? Regarding the duration of action, we would hope that a rAAV- mediated ribozyme effect might be long... straightforward methods of delivery to the subretinal space and its adjacent photoreceptors and retinal pigment... -based delivery of protective neurotrophic factors (12­15), and the introduction of ...

  

Source: Príncipe, José Carlos - Computational NeuroEngineering Laboratory, University of Florida

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
47 Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common
 

Summary:  Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6... ., 2000) or after (Kordower et al., 2000; Costa et al., 2001) the delivery of DA neurotoxins. Furthermore... -term efficacy of any treatment, including GDNF, will depend on its continuous long-term delivery

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
48 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1408314088, December 1997
 

Summary:  were performed to evaluate the time course of expression of rAAV-mediated GDNF protein expression... -mediated transgene expression is transient (27­29), but long-term rAAV-mediated transgene expression has been... neu- rons, first described by Sauer and Oertel (21), to demonstrate that rAAV-mediated nigral GDNF

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
49 JOURNAL OF VIROLOGY, Apr. 2004, p. 41654175 Vol. 78, No. 8 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.8.41654175.2004
 

Summary:  and the cell cycle can affect the efficiency of rAAV-mediated gene repair. MATERIALS AND METHODS Mutant e... with various agents known to induce rAAV trans- duction before rAAV-mediated gene repair was evaluated... or cytoplasmic injection of both forms of viral DNA. Evaluation of rAAV-mediated gene correction in transgenic

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
50 BioMed Central Page 1 of 5
 

Summary:  method for DNA delivery based on intramuscular injection of plasmids followed by electric pulses delivery... delivery by doxycycline in mice after intramuscular injec- tion of adeno-associated vector. Blood 1998, 92... production and systemic delivery of mAbs might ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
51 Silencing of Hepatic Fatty Acid Transporter Protein 5 in Vivo Reverses Diet-induced Non-alcoholic Fatty Liver Disease and
 

Summary:  , these results demonstrate that a single sdsAAV-mediated delivery of shRNA expression constructs results... in phenotypes that are highly comparable with that of genetically engineered knock-out animals and that AAV-mediated... -consuming. Further, major advantages of AAV-mediated gene knockdown over ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
52 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  ­30). These tissue-specific differences in rAAV-mediated gene transfer may be due, in part, to variable levels... . 1997. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular... . Kurtzman, and B. J. Byrne. 1996. Gene delivery to skeletal muscle results in sustained expression

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
53 GENE THERAPY Agene-deleted adenoviral vector results in phenotypic correction of canine
 

Summary:  of hemophilia. Gene Ther. 1998;5:40-49. 6. Manno CS, Chew AJ, Hutchison S, et al. AAV- mediated factor IX gene... first- and second-generation adenoviral vectors for hepatic delivery.39,40 In both studies the canine... factor VIII deficiency after delivery of first- generation and multideleted adenoviral ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
54 Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd.
 

Summary:  ). Despite its many attractive features, further optimization of AAV- mediated gene delivery (ie... . transduction) is needed before AAV-mediated gene transfer becomes therapeutically useful. Although, AAV... of Rac1 (N17Rac1) blocked rAAV- mediated induction of PI3K ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
55 For more information, please contact Prof. Frank Fisher at Frank.Fisher@stevens.edu or 201-216-8913 STEVENS INSTITUTE OF TECHNOLOGY
 

Summary:  Industrial Design, in New York, on the development of a needleless injector for intramuscular drug delivery

  

Source: Fisher, Frank - Department of Mechanical Engineering, Stevens Institute of Technology

 

Collection: Engineering

 
56 Biosafety of DNA vaccines: new generation of DNA vectors7 and current knowledge on the fate of plasmids after8
 

Summary:  The most widely employed delivery method is intramuscular injection. Naked DNA in saline173 is injected... immune responses than intramuscular delivery supported by molecular adjuvants. Genet588 Vaccines Ther... after intramuscular delivery.637 Hum Gene Ther ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
57 HUMAN GENE THERAPY 18:8187 (January 2007) Mary Ann Liebert, Inc.
 

Summary:  recombination in vivo, using a trans- splicing dual vector genetic approach. Evidence suggests that AAV-mediated... ., STORM, T.A., and KAY, M.A. (2000). Increasing the size of rAAV-mediated expression cassettes in vivo... , 6716­6721. YAN, Z., RITCHIE, T.C., DUAN, D., and ENGELHARDT, J.F. (2002). Recombinant AAV-mediated gene

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
58 Lentiviral Expression of Retinal Guanylate Cyclase-1 (RetGC1) Restores Vision
 

Summary:  /kg) delivered intramuscularly. A quarter of the initial dose was given as needed during the recording session... anesthetized with an intramuscular injection of ketamine (16 mg/kg) and euthanized using a protocol approved... . To permit use of the right and left retinas of treated animals in our analyses, we determined if ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
59 300 Current Gene Therapy, 2010, 10, 300-311 1566-5232/10 $55.00+.00 2010 Bentham Science Publishers Ltd.
 

Summary:  of administration, different doses of plas- mid DNA and different protocols for delivery of electric pulses were... been proved to be very effective in local tumor control, having also a systemic effect. Intramuscular... the antitumor effectiveness and safety of intratu- moral IL-12 gene therapy. The delivery systems for IL-12 ...

  

Source: Ljubljana, University of - Faculty of Electrical Engineering, Laboratory of Biocybernetics

 

Collection: Engineering ; Biology and Medicine

 
60 Neuropathological and Behavioral Consequences of Adeno-Associated Viral Vector-Mediated
 

Summary:  was to evaluate the effects of rAAV-mediated BDNF and NGF delivery on neuronal survival and behavioral deficits... of rAAV-mediated transgene ex- pression (Table 1B). These animals were injected bilat- erally... into the rat striatum via rAAV-mediated gene transfer, lead to mild improvements of motor ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
61 Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using
 

Summary:  -dopa using rAAV-mediated gene transfer Deniz Kirik*, Biljana Georgievska*, Corinna Burger , Christian Winkler... . Second, we show that this critical L-dopa level can be achieved by rAAV-mediated TH gene transfer... -1015 by measuring the accumulation of L-dopa. Increased rAAV-mediated striatal L-dopa in the five

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
62 A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Muller Cells
 

Summary:  of AAV-mediated gene delivery towards other retinal degenerative diseases. Importantly, genetic... (AAV) mediated ocular gene therapy holds tremendous promise for treating and potentially curing... (AMD), retinitis pigmentosa, and other blinding diseases. The therapeutic potential of ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
63 This is an Accepted Article that has been peer-reviewed and approved for publication in the Journal of Neurochemistry, but has yet to undergo copy-editing and proof correction. Please
 

Summary:  that rAAV mediated DOPA delivery resulted in functional recovery that was correlated with restoration... to explore if rAAV mediated DOPA delivery gives rise to any 3-OMD metabolite in the striatum. Although... peripheral L-DOPA medication. This is supported by the ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
64 NATURE BIOTECHNOLOGY VOL 18 MAY 2000 http://biotech.nature.com 527 Recombinant adeno-associated virus (rAAV) vectors based on AAV
 

Summary:  ), and Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two... ,15 (Nakai et al., manuscript submitted). This suggests that co- delivery of two vectors may allow... .W. et al. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
65 HUMAN GENE THERAPY 14:12551264 (September 1, 2003) Mary Ann Liebert, Inc.
 

Summary:  -inducible enhancers. Gene Ther. 7, 896­902. NAKAI, H., STORM, T.A., and KAY, M.A. (2000). Increasing the size of rAAV-mediated... delivery approachin treating patients infected with the hepatitisC virus(HCV) representsyet anotherareain... window would permit the use of higher doses of gene delivery vectors as well as the infu- ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
66 Neurobiology of Disease Positron Emission Tomography Imaging Demonstrates
 

Summary:  et al., 2005). Together, these data suggest that rAAV-mediated targeted DOPA delivery is not only... pool can be efficiently restored after rAAV-mediated gene therapy has not been achieved yet. The [11 C... predictor of the DA levels after rAAV- mediated enzyme replacement in the par- ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
67 ORIGINAL PAPER Kate Bodley Tamara van Polanen Petel
 

Summary:  initially been sedated using an intramuscular injection of midazolam. The seals were selected from colonies... delivery systems are generally bulky and require careful handling. Free-ranging Weddell seals have been... and an anaesthetic circuit, would improve patient safety by allowing accurate delivery of a known, clinically ...

  

Source: Hindell, Mark - School of Zoology, University of Tasmania

 

Collection: Environmental Sciences and Ecology

 
68 JOURNAL OF VIROLOGY, Aug. 2002, p. 76517660 Vol. 76, No. 15 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.15.76517660.2002
 

Summary:  delivery of AAV2/5.GFP.Long, AAV2.GFP.Long, and AAV2.GFP.Short using real-time PCR. VOL. 76, 2002 AAV-MEDIATED... , and J. F. Engelhardt. 2002. Recombinant AAV-mediated gene delivery using dual vector heterodimerization... , 2002 AAV-MEDIATED TRANSDUCTION OF MURINE RETINA 7653 #12;gene ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
69 original article 2096 www.moleculartherapy.org vol. 17 no. 12, 20962102 dec. 2009
 

Summary:  Limiting Membrane Barriers to AAV-mediated Retinal Transduction From the Vitreous Deniz Dalkara1... intravit- real administration. In addition, we identified the ILM as a barrier to AAV-mediated retinal... . We anticipate this finding may greatly enhance AAV- mediated retinal gene therapy with intravitreal

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
70 Characterization of Intrastriatal Recombinant Adeno-Associated Virus-Mediated Gene Transfer of Human Tyrosine Hydroxylase
 

Summary:  to be pathogenic. The present study reports that (1) rAAV-mediated hTH and hGTPCHI expression was sufficient... tested where appropriate. RESULTS Persistence of rAAV-mediated hTH and hGTPCHI gene expression... , and the animals that survived for 1 year received 2 l of vector. Neuronal specificity of rAAV-mediated gene

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
71 REVIEW Open Access T-tubule biogenesis and triad formation in
 

Summary:  , immunohistology and EM analysis revealed that AAV mediated overexpression of MTM1 in mouse muscle results

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
72 Virus Research 104 (2004) 5159 Novel approaches to augment adeno-associated virus
 

Summary:  al., 2002; Xiao et al., 1996). Recombinant AAV (rAAV) mediated gene delivery to certain tissues... ). In these tissues, rAAV mediates high level and long lasting gene expression. However, the transduction of other... .dl802 induced high levels of rAAV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
73 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  in efficiency of transduction to various tis- sues exist for rAAV. For example, rAAV-mediated gene trans- fer... the GFP (7). In these studies, adenovirus-mediated K44A dynamin I expression reduced rAAV-mediated GFP... (Fig. 2B). In contrast, prior infection with Ad.LacZ had no effect on rAAV-mediated gene expression

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
74 Principal Investigator/Program Director (Last, first, middle): Samulski, Richard Jude BIOGRAPHICAL SKETCH
 

Summary:  and Broad Dispersion of AAV-Mediated Transgene Expression in Mouse Brain. Molecular Therapy, 8... . Gene Therapy of Canavan Disease: AAV-2 Vector for Neurosurgical Delivery of Aspartoacylase Gene (ASPA... -human Primate After Subretinal Delivery. Molecular Therapy, 7(6):774-781, 2003. Lehmann T, Wheeler M, Froh M

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
75 original article The American Society of Gene Therapy Molecular Therapy 1
 

Summary:  that bilateral recombinant adeno-associated virus (rAAV)-mediated overexpression of GDNF in the hypothalamus... behavior and energy homeostasis. However, hypothalamic DA levels were unaffected by long-term rAAV-mediated... -mail: rmandel@ufl.edu Nigrostriatal rAAV-mediated GDNF Overexpression Induces Robust Weight Loss in a Rat ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
76 Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host
 

Summary:  and the lack of strong inflammatory responses to AAV- mediated gene transfer are all attractive features... . A logical extension of this hypothesis provides an explanation for the difference in outcome of AAV-mediated... , hemophilic dogs and nonhuman primates, have shown long-term expression of the transgene after ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
77 Brain Research 886 (2000) 8298 www.elsevier.com/locate/bres
 

Summary:  to be effective for long-term delivery of glial cell line-derived neurotrophic factor (GDNF) at biologically... , moreover, that sustained GDNF delivery over 3­6 months can promote regeneration and significant functional... 35 kb [27,49,62]. hydroxydopamine (6-OHDA)- or MPTP-induced damage, Intracerebral delivery of GDNF

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
78 Impact of three ampicillin dosage regimens on selection of ampicillin1 resistance in Enterobacteriaceae and excretion of blaTEM genes in swine feces2
 

Summary:  real-time PCR assay. Ampicillin was administered intramuscularly and by oral26 route to fed or fasted... /g of feces for32 intramuscular and oral routes, respectively. Whereas phenotypic evaluations did not33... and the percentage of resistant Enterobacteriaceae. The three70 dosage regimens tested were: intramuscular route

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
79 NATURE MEDICINE VOLUME 7 NUMBER 1 JANUARY 2001 33 Converting a virus into a vector
 

Summary:  transfer strategies based on the delivery of tumor- specific toxins or the conversion of prodrugs... to engineer recombinant viral vectors for the delivery of thera- peutic genes into diseased tissues. While... of hepatocytes38 . The actual potential and limits of lentiviral vector-mediated gene delivery in vivo still need

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
80 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  (18) and in vivo in various organs (2, 4, 10, 12, 26, 27), the mechanisms of rAAV-mediated... ). Recombinant AAV (rAAV) has recently been recognized as an extremely attractive vehicle for gene delivery (18... intramuscular injection of recombinant adeno-associated virus. Proc. Natl. Acad. Sci. USA 94:5804­5809. 11. Hyde

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
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81 Systemic Mannitol-Induced Hyperosmolality Amplifies rAAV2-Mediated Striatal Transduction to a
 

Summary:  impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene... -term rAAV mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral... of mannitol significantly enhances transgene spread of rAAV2 viral ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
82 Current Gene Therapy, 2003, 3, 281-304 281 1566-5232/03 $41.00+.00 2003 Bentham Science Publishers Ltd.
 

Summary:  properties making them very attractive for therapeutic gene delivery to humans, such as a lack... being divided into small compartments, which is ideal for precise vector delivery. Moreover, animal... efficiently transduce photoreceptors and RPE cells, which both are interesting targets for gene delivery

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
83 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.16.76627671.2001
 

Summary:  . For these reasons, efforts aimed at increasing the efficacy of AAV-mediated gene delivery to muscle have... a significant impact on improving rAAV-mediated gene therapy in muscle. Muscle-based gene therapy protocols have... infection (Fig. 8B and D). However, the level of rAAV-mediated EGFP expression was ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
84 Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a
 

Summary:  the intramuscular route or with shigella 15D harboring pYUB2406 [designated 15D(pYUB2406)] (Fig. 1). After... virus or with pYUB2406 via the intramuscular route, but not in mice immunized with shigella 15D(pYUB2406... washings from 15D(pYUB2406)-immunized mice, albeit at levels much lower than in washings of intramuscular p

  

Source: Albert Einstein College of Medicine, Department of Microbiology and Immunology, Tuberculosis Research Group

 

Collection: Biology and Medicine

 
85 Ovarian cancer gene therapy strategies Parameshwar J. Mahasreshti, Manjula Kataram, Ronald D.
 

Summary:  , Ronald D. Alvarez, Hidde J. Haisma, and David T. Curiel. Submitted to Expert Opinion on Drug Delivery #12... delivery vectors for ovarian cancer therapy 30 7.1. Viral vectors 30 7.1.1. Adenovirus 30 7.1. 2... of disease mostly to abdominal cavity and easy access to the peritoneal cavity for the delivery of genes

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
86 Influenza vaccination is the key stone in controlling re-occurring influenza epidemics. The studies described in this thesis evaluated dry-powder formulation of influenza vac-
 

Summary:  the intramuscular (i.m.) or subcutaneous (s.c.) route using needles and syringes. Needle-free delivery, such as muco... to stabilize biopharmaceuticals, such as proteins, vaccines and gene delivery systems, is to dry them... of the HA potency, upon storage. Also the capacity of virosomes to mediate cellular ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
87 p a r t t H r e e SuMMAry And PerSPectIVeS
 

Summary:  of vaccines for mucosal delivery 1.1. evaluation of gem particles as a novel adjuvant In this part... vaccines were administered via three different routes; (i) intramuscular (i.m.), (ii) intranasal (i... .n.), and (iii) gastro- intestinal (g.i.). The i.m. delivery of GEM adjuvanted vaccines was studied to evaluate

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
88 HUMAN GENE THERAPY 19:6169 (January 2008) Mary Ann Liebert, Inc.
 

Summary:  ). Intramuscular viral delivery of paraplegin rescues peripheral ax- onopathy in a model of hereditary spastic... delivery could be useful for disorders such as spinal mus- cular atrophy and amyotrophic lateral sclerosis... skeletal muscle. Studies have used intramuscular injections of adeno- associated virus ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
89 Introduction Few infectious diseases cause such a huge annual toll of morbidity, mortality, and eco-
 

Summary:  biopharmaceuticals, such as proteins, vaccines and gene delivery systems, is to convert them into a dry... are generally administered via the intramuscular (i.m.) or subcutaneous (s.c.) route using needles and syringes... delivery, such as mucosal delivery via the respiratory or gastro-intestinal tract, may ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
90 Recording Intramuscular EMG Signals Using Surface Electrodes Nikolay S. Stoykov, Madeleine M. Lowery, Charles J. Heckman, Allen Taflove, and Todd A. Kuiken
 

Summary:  Recording Intramuscular EMG Signals Using Surface Electrodes Nikolay S. Stoykov, Madeleine M... and wrist prostheses. A completely embedded passive conductor is proposed to transmit intramuscular EMG... can then be recorded with conventional surface electrodes. The surface recorded intramuscular EMG (SRI

  

Source: Northwestern University, Rehabilitation Institute of Chicago, Sensory Motor Performance Program (SMPP)

 

Collection: Biology and Medicine ; Engineering

 
91 Behavioral/Systems/Cognitive Cdk5 Modulates Cocaine Reward, Motivation, and Striatal
 

Summary:  ) riboprobes after rAAV-EGFPCre delivery. C, Quantitative immunoblotting of rAAV- mediated NAc... by rAAV-mediated Cdk5 NAc-KO. Effect of NAc-specific loss of Cdk5 on cocaine-induced behavioral... . To investigate the role of Cdk5 specifically in the postsynaptic compartment of striatal neurons, we used ...

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine

 
92 nature genetics volume 24 march 2000 257 Evidence for gene transfer and expression of factor IX
 

Summary:  that AAV-mediated gene therapy for haemophilia B is safe and has the potential to demonstrate efficacy... . Intramuscular injection of an AAV vector expressing human F.IX into immunodeficient mice caused expression of F... )/kg; ref. 1). Subsequently, intramuscular injection of an AAV vector expressing canine F.IX in dogs

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
93 JOURNAL OF VIROLOGY, June 2004, p. 63446359 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.63446359.2004
 

Summary:  infection. Regardless, the data show that the presence of high levels of NAb against wt AAV can reduce rAAV-mediated... for the possibility that rAAV-mediated GDNF expression levels increase over time. Blood was drawn for NAb titer assay... of preexisting immunity to wt AAV2 on rAAV-mediated transgene expression, neuroinflam- ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
94 HUMAN GENE THERAPY 14:871881 (June 10, 2003) Mary Ann Liebert, Inc.
 

Summary:  - cytes should be much higher than the copy numbers per cell shown in this paper. In rAAV-mediated liver... delivery to skeletal muscle results in sus- tained expression and systemic delivery of a therapeutic... delivered with intramuscular instillations of adeno-associated vec- tors. Hum. Gene Ther. 11, 777

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
95 Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal But Not Intranigral Transduction
 

Summary:  ). Reversal of lesion-induced functional impairments by rAAV-mediated GDNF delivery Beginning 3 weeks after... Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson's Model: Intrastriatal... for the nigral DA neurons and their targets raises the possibility that rAAV-mediated gene transfer can be ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
96 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  pathology may be superior to infecting sick and dying neurons (Fig. 2A and B). rAAV mediated over... . Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity... to be developed as a delivery method to treat neurological disorders, certain criteria need ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
97 Suppression of Insult-Induced Neurogenesis in Adult Rat Brain by Brain-Derived Neurotrophic Factor
 

Summary:  cerebral cortex (30). It could be argued that the rAAV-mediated high BDNF levels do not inhibit but delay... , it is inconceivable that they will differentiate into neurons under conditions when rAAV-mediated production of high... by global forebrain isch- emia in rats. Our data indicate that long-term delivery of a neurotrophic ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
98 Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA
 

Summary:  increased the 5hmC level by 43% (Figure 6A). On the other hand, AAV-mediated 428 Cell 145, 423­434, April 29... in the adult dentate granule cells (Ma et al., 2009b). AAV- mediated overexpression of TET1 or AID, but not TET... after AAV-mediated expression (Figure S7D and Table S1). Interestingly, knockdown ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
99 SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret,
 

Summary:  - associated virus (rAAV)-mediated gene therapies to the lung for cystic fibrosis (CF). As new ferret and pig... appropriate animal model to test rAAV- mediated gene therapies for CF lung disease. The testing of gene... for gene delivery to the airway in these species. However, despite the high degree of ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
100 INSTITUT NATIONAL AGRONOMIQUE PARIS-GRIGNON Ecole Doctorale ABIES
 

Summary:  - associated virus (rAAV)-mediated gene therapies to the lung for cystic fibrosis (CF). As new ferret and pig... appropriate animal model to test rAAV- mediated gene therapies for CF lung disease. The testing of gene... for gene delivery to the airway in these species. However, despite the high degree of ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics


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