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Sample search results for: abasic site analogues

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1 Oligonucleotides with Bistranded Abasic Sites Interfere with Substrate Binding and Catalysis by Human Apurinic/Apyrimidinic Endonuclease
 

Summary:  a similar substrate contained a single abasic site but a nick followed by the abasic site analogue, 5... contralateral strand with an abasic site analogue on the downstream strand was an even poorer substrate than... ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
2 Noncovalent Spin Labeling DOI: 10.1002/anie.201002637
 

Summary:  ,7] The strategy for noncovalent labeling was to disconnect the glycosidic bond of C¸ to give an abasic site (F... ) and the free spin-labeled base ç (Figure 1). The spin label would bind in the abasic site through receptor... containing an abasic site with ç, a ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
3 Site-Directed Spin-Labeling of Nucleic Acids by Click Chemistry: Detection of Abasic Sites in Duplex DNA by EPR
 

Summary:  containing a stable analogue of an abasic site, 3-hydroxy-2-(hydroxymethyl)-tetrahydrofuran. Introduction... Site-Directed Spin-Labeling of Nucleic Acids by Click Chemistry: Detection of Abasic Sites... that can detect and identify local structural deformations in ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
4 DNA Repair 3 (2004) 14471455 Novel role of tyrosine in catalysis by human AP endonuclease 1
 

Summary:  analogue. In sum, tyrosines not only play critical roles in binding and recognition of abasic site... ) recognizes abasic sites in ds DNA and makes a single nick in the backbone 5 to the abasic site... . We show that Tyr128 and Tyr269 , which ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
5 Molecular Cell, Vol. 13, 751762, March 12, 2004, Copyright 2004 by Cell Press Snapshots of Replication through
 

Summary:  B homolog) from two related Sulfolobus strains are able to extend primer strands past abasic sites... with the abasic site looped out and finger and little finger domains provides an entry channelthe incoming... when the abasic site remains extrahelical. incoming ...

  

Source: Ling, Hong - Department of Biochemistry, University of Alberta

 

Collection: Biology and Medicine

 
6 A Core Folding Model for Catalysis by the Hammerhead Ribozyme Accounts for Its Extraordinary Sensitivity to Abasic Mutations
 

Summary:  was individually replaced by an abasic nucleotide analogue (Chart 1) (8, 9). Removing individual bases from DNA... , abasic nucleotide analogues were found to decrease the duplex stability by 4-6 kcal/mol at the same... Sensitivity to Abasic Mutations Alessio Peracchi,,§ Alexander ...

  

Source: Herschlag, Dan - Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine

 
7 Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a
 

Summary:  DNA: an abasic site and a helix terminus. Because these comparisons are looking for small effects... of the oligonucleotides (Fig. 1). When paired with a tetrahydrofuran abasic site analog on the complementary strand... probe and its complementary abasic site. The ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
8 Submitted to J. Biol. Chem. Draft of July 13, 2001
 

Summary:  /apyrimidinic endonuclease; ASR, abasic site repair, bp, base pair; ds, double-stranded; ESR, electron spin resonance; HDP... structure, ss, single- stranded #12;3 Introduction Abasic site repair (ASR) refers to one of several repair... pathways that generate and repair an abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
9 Human Apurinic/Apyrimidinic Endonuclease Is Processive, Daniel C. Carey and Phyllis R. Strauss*
 

Summary:  abasic sites in the base excision repair pathway. AP endo makes a single nick 5 to an abasic site... in double-stranded DNA. In this study, we investigated whether AP endo locates an abasic site through... a processive or a distributive mechanism. We used a linear ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
10 Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
 

Summary:  to be a promising candidate for replication by base filling since the abasic reaction site is a versatile secondary... -PNA duplexes.8,9 We found that incorporation of an abasic site had a parallel, though more dramatic effect... of the duplex) (Table 1). Next we tested the ability of PNA bases to fill a ...

  

Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University

 

Collection: Chemistry ; Biology and Medicine

 
11 Substrate Binding by Human Apurinic/Apyrimidinic Endonuclease Indicates a Briggs-Haldane Mechanism*
 

Summary:  Apurinic/apyrimidinic endonuclease (AP endo) makes a single nick 5 to a DNA abasic site. We have character... the abasic site during treatment with uracil-DNA glycosylase with a reducing agent. Otherwise, a 20-mer... M and 10 s 1 , respectively. Heat treatment of the abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
12 Abasic Site Repair in Higher Eukaryotes Phyllis R. Strauss and Noreen E. O'Regan
 

Summary:  3 Abasic Site Repair in Higher Eukaryotes Phyllis R. Strauss and Noreen E. O'Regan 1. INTRODUCTION... of abasic sites generated per mammalian cell per day run as high as 106/cell/d (88). Abasic sites... the large number of abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
13 Charge Transport in DNA Oligonucleotides with Various Base-Pairing Patterns Irena Kratochvilova,*,
 

Summary:  A, G, C, and T) and dSpacer CE Phosphoramidite (for abasic sites) were purchased from Glen Research... duplex interior at the abasic sites can partially compen- sate for the loss of overlap between the base... . Structurally and thermally much less stable abasic duplexes have still lower ...

  

Source: Kužel, Petr - Institute of Physics, Academy of Sciences of the Czech Republic

 

Collection: Physics

 
14 Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
 

Summary:  , abasic sites, or oxidized bases) on opposing strands--are suspects as critical lesions producing lethal... at an oxidized base or abasic site. If there are two closely spaced damages on opposing strands, such cleav- age... DNA damages containing abasic sites, ...

  

Source: Brookhaven National Laboratory, Environmental Chemistry Division, Department of Applied Science

 

Collection: Environmental Sciences and Ecology

 
15 Notes & Tips A nonisotopic assay for unambiguous assignment of DNA
 

Summary:  but leave be- hind an abasic or apurinic/apyrimidinic (AP)1 site in DNA [4]. Thus, for the analysis... strand scission adjacent to the abasic site. The lack of current DNA glycosylase assays to concur- rently... denaturing PAGE, taking into account the inherent lability of abasic ...

  

Source: Boston University, Center for Advanced Biotechnology

 

Collection: Biotechnology

 
16 Effect of Protein Binding on Ultrafast DNA Dynamics: Characterization of a DNA:APE1 Complex
 

Summary:  oligonucleotide at the abasic site opposite the coumarin with only a fourfold reduction in rate. In addition... in binding constant relative to a native oligonucleotide containing a guanine opposite the abasic site. Thus... a fluorescent coumarin group replaces a native base (Fig. 1) (7). An ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
17 Pure Appl. Chem., Vol. 83, No. 3, pp. 677686, 2011. doi:10.1351/PAC-CON-10-09-28
 

Summary:  on noncovalent interactions between a spin-labeled nucleobase and an abasic site in duplex DNA. Keywords: EPR... Postsynthetic spin labeling of nucleobases by click chemistry: Detection of abasic sites The success... been used to detect abasic sites in DNA [21], ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
18 Single-Turnover Analysis of Mutant Human Apurinic/Apyrimidinic Endonuclease, Julie A. Lucas, Yuji Masuda,|, Richard A. O. Bennett,| Nathaniel S. Strauss,,@ and Phyllis R. Strauss*,
 

Summary:  and cleavage of abasic site-containing DNA. Apurinic/apyrimidinic endonuclease (AP endo) is a human enzyme... that is critical to the repair of abasic sites in DNA arising through either base excision repair or oxidative... damage. AP endo recognizes abasic sites in ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
19 Domain Mapping of Human Apurinic/Apyrimidinic Endonuclease STRUCTURAL AND FUNCTIONAL EVIDENCE FOR A DISORDERED AMINO TERMINUS AND A TIGHT
 

Summary:  , became strikingly less accessible to protease digestion in the presence of abasic site-containing DNA... of the nuclease fold, there must be multiple means by which DNA containing an abasic site associates... in the repair of abasic sites in DNA. These ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
20 Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases and REV1
 

Summary:  is a deoxycytidyl transferase that shows the highest catalytic activity opposite template guanines and abasic sites... (14, 15). Rev1 is primarily responsible for inserting dC residues opposite abasic sites during... oligonucleotide-based system was used in which the template strand contained a model ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine


Page:   2  3  4  5 
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21 An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals
 

Summary:  Backbone 1749 2.4. Properties of Abasic Sites Arising from Depurination 1749 3. Overview: Common Reactions... ). The oxocarbenium ion undergoes subsequent hydrolysis to yield an abasic site 7 (often referred to as an apurinic... site or AP site). It is calculated that ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
22 Dissociative electron attachment to abasic DNA Sylwia Ptasin ska* and Le on Sanche
 

Summary:  by the presence of an abasic site; in both XCAT and GCXT, the yield of detached bases was found to be up... not depend very much on the presence of an abasic site in GCAT. From a purely classical point of view... of an abasic site. In experiments with 40-base pair ...

  

Source: Simons, Jack - Department of Chemistry, University of Utah

 

Collection: Chemistry

 
23 Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase
 

Summary:  is replaced with an abasic site (Table 2). F84A is decreased dramatically in catalysis as well (Table 3, 1000... of WT and F124A M.HhaI were examined using the base analogue 2-amino- purine (2AP) at the target site... -GGGAATTCATGG^GCAGTGGGTGGATCCAG-3 3-CCCTTAAGTACCGCMe GTCACCCACCTAGGTC-5 ...

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine

 
24 Identification of the Hammerhead Ribozyme Metal Ion Binding Site Responsible for Rescue of the Deleterious Effect of a Cleavage Site Phosphorothioate
 

Summary:  and substrate variants at positions P9, G10.1, and P1.1 (the cleavage site). Abasic and phenyl... of the abasic ribozymes. Presumably, the Cd2+ ion is bound and sequestered at the P9/G10.1 site and occasionally... Identification of the Hammerhead Ribozyme Metal Ion Binding Site ...

  

Source: Herschlag, Dan - Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine

 
25 Base Excision and DNA Binding Activities of Human Alkyladenine DNA Glycosylase Are Sensitive to the Base Paired with a Lesion*
 

Summary:  affinity of human alkylad- enine DNA glycosylase to a DNA product containing an abasic site was similar... , it had no effect when placed opposite G or A. Binding of hAAG 79 to DNA Duplexes Containing Abasic Sites... substrates containing a synthetic abasic site was ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
26 A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli
 

Summary:  pair or an abasic site, we found a small number of proteins that could recognize each type of probe... 7 N = Control A:C mismatch G:T mismatch Abasic site:G Abasic site:A Abasic site:C Abasic ...

  

Source: Chen, Chien-Sheng - Institute of Systems Biology and Bioinformatics, National Central University

 

Collection: Biology and Medicine

 
27 3-Methyladenine DNA glycosylases: structure,
 

Summary:  to produce an abasic site. The abasic site is then processed by one of two pathways, termed short... generates a DNA strand break at the abasic site and the abasic terminus is removed by deoxyribo- phosphatase... by a replicative polymerase.AP ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
28 INTRINSIC PROPERTIES OF THE TWO REPLICATIVE DNA POLYMERASES OF PYROCOCCUS ABYSSI IN REPLICATING ABASIC SITES: POSSIBLE ROLE IN DNA
 

Summary:  ABASIC SITES: POSSIBLE ROLE IN DNA DAMAGE TOLERANCE ? 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20... , France. Running Tittle : DNA synthesis by Pabpols of DNA containing abasic sites * Corresponding author... 39 40 41 Spontaneous and induced abasic sites in ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
29 Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase *
 

Summary:  by Pol on undamaged DNA. PCNA also stimulated translesion synthesis of a model abasic site by Pol... experimental conditions, facile by- pass of the abasic site was also detected by DNA polym- erase or (Rad30... Synthesis of a Model Abasic Site--To determine which ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
30 Cell, Vol. 95, 249258, October 16, 1998, Copyright 1998 by Cell Press Crystal Structure of a Human Alkylbase-DNA
 

Summary:  ., 1997; David and Williams, 1998). The resultingBoston, Massachusetts 02115 abasic (AP) sites are further... nucleotide to flip into the en- sylase reaction, a pyrrolidine abasic nucleotide, which zyme active site... ) on either side of the pyrrolidine site (Fig- either side of the ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
31 Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells
 

Summary:  to generate SSBs via a -elimination reaction that cleaves the O-P bond on the 3- side of the abasic site (22... of an abasic site (29, 30). To obtain clear evidence that leinamycin-induced DNA strand breaks may... spontaneously occur via -elimination reactions at aldehydic abasic ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
32 Chemical Properties of the Leinamycin-Guanine Adduct Tony Nooner, Sanjay Dutta, and Kent S. Gates*
 

Summary:  sites in DNA under physi- ological conditions. Abasic sites, and the strand breaks... of the abasic sites generated by depurination of the leina- mycin-guanine adduct. This suggestion is spurred... ), thus render- ing cells hypersensitive to the effects of abasic ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
33 PRINCIPAL ANGLES BETWEEN SUBSPACES IN AN A-BASED SCALAR PRODUCT: ALGORITHMS AND PERTURBATION
 

Summary:  PRINCIPAL ANGLES BETWEEN SUBSPACES IN AN A-BASED SCALAR PRODUCT: ALGORITHMS AND PERTURBATION... the method to the computation of principal angles in an A-based scalar product for a symmetric and positive... SUBSPACES IN A-BASED SCALAR PRODUCT 2011 Proof. The proof of the theorem is straightforward if based

  

Source: Knyazev, Andrew - Department of Mathematics, University of Colorado at Denver

 

Collection: Mathematics

 
34 Multiple Cleavage Activities of Endonuclease V from Thermotoga maritima: Recognition and Strand Nicking Mechanism
 

Summary:  the uracil base and with AP endonucleases and other enzymes to repair the subsequent abasic site (4, 5... that E. coli endoV plays a significant role in deoxyinosine and abasic site repair (19). More recent... -stranded oligonucleotides containing the abasic site (AP ...

  

Source: Barany, Francis - Biochemistry and Structural Biology Program, Weill Cornell Graduate School of Medical Sciences

 

Collection: Biology and Medicine

 
35 DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG)
 

Summary:  to other glycosylase-DNA structures, the abasic ri- bose is not flipped into the TAG active site... a tetrahydrofuran (THF) abasic site analog. The THF moiety is isosteric with enzymatically generated apuri- nic... -chain and main- chain atoms from the HhH motif bind the phosphate groups 30 to the ...

  

Source: Eichman, Brandt F. - Department of Biological Sciences, Vanderbilt University

 

Collection: Biology and Medicine

 
36 Molecular Cell, Vol. 20, 367375, November 11, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.molcel.2005.09.018 MRE11/RAD50 Cleaves DNA
 

Summary:  by deamination of cytosine to uracil, followed by removal of uracil to create an abasic (AP) site. We find... in the hypermutation mecha- nism, and that purified, recombinant MRE/RAD50 (MR) can cleave DNA at abasic sites... can cleave at abasic sites, we adopted a ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
37 Correlation of mitochondrial superoxide dismutase and DNA polymerase b in mammalian dermal fibroblasts with species maximal lifespan
 

Summary:  in parallel to APE activity assays: the addition of control oligonucleotide (no abasic site analogue); no cell... was determined through incision of an oligonucleotide containing a THF abasic site analogue (THF, Table 2... -stranded oligonucleotide containing a tetra- ...

  

Source: Stuart, Jeffrey A. - Department of Biological Sciences, Brock University

 

Collection: Biology and Medicine

 
38 University of Maryland Baltimore Graduate School Announcement of Doctoral Dissertation Defense
 

Summary:  of these damaged bases result in the formation of an abasic or AP site, allowing the next enzyme in the pathway... , Apurinic/Apyrimidinic Endonuclease 1 (APE1), to hydrolytically cleave the DNA backbone 5' to the AP site... binding sites for two redox (another APE1 function) inhibitors of APE1, one of which ...

  

Source: Weber, David J. - Department of Biochemistry and Molecular Biology, University of Maryland-Baltimore

 

Collection: Biology and Medicine

 
39 My Cart My Profile Log In Athens Log In Journal Home | OnlineOpen | Accepted Articles | Society | News | Reviews | Read Cover Story | Most Accessed | Most Cited | Professional Opportunities
 

Summary:  to the sarcin/ricin loop, signal the presence of RNA abasic sites generated by ribosome inactivating proteins... -Mail Alert Email this page Print this page RSS web feed (What is RSS?) A Journal of the Go to Society Site... energies down to 5 eV. This reaction is strongly site- and energy-selective for C5 of ...

  

Source: Lin, Zhiqun - Department of Materials Science and Engineering, Iowa State University

 

Collection: Materials Science

 
40 RNA folding and the origins of catalytic activity in the hairpin ribozyme Timothy J. Wilson a
 

Summary:  activity [26], while 10,000-fold loss of activity resulted from an abasic site at position 38 [27... of abasic sites in the core of the hammerhead ribozyme showed that some positions could be rescued while... The nucleolytic ribozymes catalyse site-specific phosphodiester cleavage and ...

  

Source: Ha, Taekjip - Department of Physics, University of Illinois at Urbana-Champaign

 

Collection: Physics ; Chemistry ; Biology and Medicine


Page:   1  2  3  4  5 
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41 Measurement of Local DNA Reorganization on the Picosecond and Nanosecond Time Scales
 

Summary:  in the Experimental Section) shows that when it is positioned opposite the abasic-site analogue 2 in helical B... and abasic-site analogue 2 that form a base-pair analogue with good photophysical properties. Measurement... strand has the abasic ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
42 Analysis of the RNA-Editing Reaction of ADAR2 with Structural and Fluorescent Analogues of the GluR-B R/G Editing Site
 

Summary:  for an ADAR-induced base flipping. Herein we describe the generation of R/G editing site analogues from Glu... Site. 2-Aminopurine (2-AP) is a fluorescent nucleic acid base analogue whose quantum yield and emission... both strands of duplex DNA over the 6 bp that surround an abasic ...

  

Source: Beal, Peter A. - Department of Chemistry, University of Utah

 

Collection: Chemistry

 
43 ALGEBRAIC L-T}~0RY III. TWISTED LAUREI~ EXTENSIONS
 

Summary:  +_(P);L,P~) : (~, ,~',~ defined for some based A-modules P,P'. 425 #12;15 Theorem 2.1 has a based analogue: Theorem ~.I For n... .2 has a based analogue S CA)Lemm.a. ~.2 (Q,~;F,G~(Q,~;G,H) = (Q,~;F,H) £ V2i+l I ~(P,e) e s } [] 426 #12... -groups in [9] and [10]. The exact sequence of Theorem 2.3 has a based analogue Theorem 3.3 ...

  

Source: Ranicki, Andrew - School of Mathematics, University of Edinburgh

 

Collection: Mathematics

 
44 A Base Change in the Catalytic Core of the Hairpin Ribozyme Perturbs Function but Not Domain Docking
 

Summary:  Institute. 1 Abbreviations: ab, abasic site with 2-deoxyribose; AP, 2-ami- nopurine; dT, deoxythymidine... (Table 1). When converting the +2 position into an abasic site with a 2-deoxyribose (ab), however, the 8... values to 10% or less. b dT ) 2-deoxythymidine; ab ) abasic ...

  

Source: Walter, Nils G. - Department of Chemistry, University of Michigan

 

Collection: Chemistry ; Biotechnology ; Biology and Medicine

 
45 DNA Damage Induced by Low-Energy Electrons: Electron Transfer and Diffraction Yi Zheng, J. Richard Wagner, and Leon Sanche*
 

Summary:  of GCXTand XCATwhere X represents a stable abasic site in which the base is replaced by a hydrogen atom... of the backbone at sites that are distant from the abasic site (i.e., in the yield functions pCXT, Gp, p... , the 10 eV resonance at sites 8 and 9 associated ...

  

Source: Simons, Jack - Department of Chemistry, University of Utah

 

Collection: Chemistry

 
46 Investigating the Role of the Little Finger Domain of Y-family DNA Polymerases in Low Fidelity Synthesis and Translesion Replication*
 

Summary:  an abasic site and a thymine-thymine cyclobutane pyrimidine dimer, and predominantly makes base pair... -thymine cyclobutane pyrimidine dimers (CPDs) (15, 18, 19) and abasic sites (15, 20). In contrast, Dbh is a much more... , and bypasses an abasic site with very low ...

  

Source: Ling, Hong - Department of Biochemistry, University of Alberta

 

Collection: Biology and Medicine

 
47 Genome Biology 2004, 5:211 commentreviewsreportsdepositedresearchinteractionsinformationrefereedresearch
 

Summary:  removes U, leaving an abasic site. Subsequent steps generate single-strand breaks [17], which become... endonucleases to nick the abasic site so that new DNA synthe- sis can recreate the duplex [6]. Reasoning... , and that uracil-DNA glyco- sylase removes U to produce an abasic ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
48 Crystal structure of a DNA containing the planar, phenoxazine-derived bi-functional
 

Summary:  been used for non-covalent spin labeling of nucleic acids containing an abasic site (26), and its... duplex DNA containing C¸ at position 2 was initially refined with an abasic site at this position... .oxfordjournals.orgDownloadedfrom #12;detection of abasic sites ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
49 Molecular dynamics of B DNA Supplementary Animations
 

Summary:  entirely out of the double helical stack, thereby eliminating the (A·T)13 base pair and forming an abasic... and TTCC B half sites which together comprise the nonameric 5' AGAANTTCC3' DNA recognition element for (c

  

Source: Mura, Cameron - Department of Chemistry, University of Virginia

 

Collection: Chemistry

 
50 Formal Verification of Control Software: A Case Study
 

Summary:  to be halted while a technician travels to the site to repair the problem. The design of concurrent software... with a set of properties to Java. #12;1 SEQUENCE Handling 2 3 STEP A.Base_0: 4 Hold1.Base(); 5 Hold2.Base... (); 6 NEXT_STEP; 7 8 9 STEP A.Base_1: 10 IF Hold1.InBase() AND 11 Hold2.InBase() THEN 12 Vert.Work(); 13

  

Source: Technische Universität Graz, Institute for Software Technology

 

Collection: Computer Technologies and Information Sciences

 
51 Sodium-Ion Binding to DNA: Detection by Ultrafast Time-Resolved Stokes-Shift Spectroscopy
 

Summary:  ) coumarin, which is paired with an abasic-site analogue in the complement.) We have reported results... ions is unresolved, as is the exact position of the important binding sites. Do ions bind in the minor... prevent close approach of the TBA to sites on the DNA. It is reasonable to regard these strong ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
52 NATURE BIOTECHNOLOGY VOL 17 JULY 1999 http://biotech.nature.com 639 When Cinderella disappeared in great haste
 

Summary:  . In their experiments, a comparison was made between incorporation efficien- cies of pyrene opposite the abasic site... -pair analog consisting of pyrene opposite an abasic site in B-form geometry (Courtesy E.T. Kool). © 1999... a template site lacking a base. This study can be viewed as ...

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
53 Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis
 

Summary:  in nucleotide incor- poration either directly opposite a lesion or at undamaged tem- plate sites... , and subsequently at a site immediately downstream of the lesion, where RecA mode 2 cocatalyzes lesion bypass. We... to a site of DNA damage and to stabilize the pol V-RecA interaction at the lesion. However, it is only a Rec

  

Source: Cox, Michael M. - Department of Biochemistry, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
54 Direct Real Time Observation of Base Flipping by the EcoRI DNA Methyltransferase*
 

Summary:  for the binding of the methyltransferase to DNA containing abasic sites or base analogs incorpo- rated... (purine), or a stable abasic site (spacer)); bot- tom strands, d(CCGCGAATTCCGCC), d(CCGCGAATTCCGCC), and d... active site. The ener- getics and kinetics of base flipping by the EcoRI ...

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine

 
55 The Coupling of Tight DNA Binding and Base Flipping IDENTIFICATION OF A CONSERVED STRUCTURAL MOTIF IN BASE FLIPPING ENZYMES*
 

Summary:  for the binary structure with AdoMet and the tertiary structure with an abasic target site (see red and black... -crystal structure of the cognate cytosine target site (3MHT) and the abasic target site (9MHT), and this net... 3 Ala mutant and the tight binding of ...

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine

 
56 DNA polymerases in adaptive immunity Jean-Claude Weill and Claude-Agns Reynaud
 

Summary:  . Effectively, the action of UNG is restricted to uracil excision, giving rise to abasic sites, and... -passing abasic sites, one should expect that inactivation of a polymerase involved in SHM would result... a deoxycytidyltransferase activity that is directed opposite various damaged bases, as well as ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
57 Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer,
 

Summary:  Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants... that contribute to catalysis within the hairpin ribozyme active site, structures for five base variants were... members catalyze a reversible, site-specific phosphodiester bond cleavage reaction within a complementary

  

Source: Wedekind, Joseph E. - Department of Biochemistry and Biophysics, University of Rochester

 

Collection: Biology and Medicine

 
58 Mechanisms of Base Selection by the Escherichia coli Mispaired Uracil Glycosylase*S
 

Summary:  -glycosidic bond. The result- ing abasic site is then processed and the damaged segment is resynthesized by a group... had a high affinity for the abasic site remaining in DNA following glycosylase removal of uracil (22... ). The high affinity for the abasic site would ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
59 Z .Mutation Research 460 2000 201210 www.elsevier.comrlocaterdnarepair
 

Summary:  then expose the target nu- cleotide and cleave the glycosylic bond. The result- ing abasic site is processed... out 1-azaribose abasic nucleotide in the active site of AlkA shows that the 3-methyl- adenine base... , abasic site, base mismatch the probe, Leu125 in AlkA ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
60 Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase*S
 

Summary:  at the pause sites. Pre-steady State Kinetic Studies of Abasic Lesion Bypass MARCH 16, 2007·VOLUME 282·NUMBER... Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase*S Received for publication... in vivo. These unrepaired abasic lesions are expected to be bypassed by Dpo4, the only ...

  

Source: Suo, Zucai - Department of Biochemistry, Ohio State University

 

Collection: Biology and Medicine


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61 Nucleobase catalysis in ribozyme mechanism Philip C Bevilacqua1,2
 

Summary:  . In addition, the structure revealed four ordered waters in the active site of the pre-cleavage state... flanking the cleavage site stack on two guanosines, G8 and G12, in a transient conformation... . There are two general approaches: rescue of an inactivated abasic (ab) ribozyme mutant by addition of a small

  

Source: Bevilacqua, Philip C.- Department of Chemistry, Pennsylvania State University

 

Collection: Chemistry

 
62 DEMETER DNA Glycosylase Establishes MEDEA Polycomb Gene Self-Imprinting
 

Summary:  -glycosylic bond, creating an abasic site, whereas the lyase activity nicks the DNA. An AP endonuclease generates... of the phospho- diester bonds (Figure 3A). Cleavage 50 to the abasic site of the b or d elimination produced... , perhaps due to the formation of mutagenic abasic ...

  

Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
63 Forma: A Framework for Safe Automatic Array University of Alberta
 

Summary:  [k].satfield) &(Asati [k].satfield') 7 allocation site: Abase=new(N*E) A=new(N*E) for i [1, SatNum] Asati = Abase... [k].pointeri satfield') 7 allocation site: Abase=new(N*NewE) A=new(N*E) for i [1, SatNum] for j [0, N-1] Abase... of the original array. From ...

  

Source: Amaral, José Nelson - Department of Computing Science, University of Alberta

 

Collection: Computer Technologies and Information Sciences

 
64 Power-Law Solvation Dynamics in DNA over Six Decades in Time Daniele Andreatta, J. Louis Perez Lustres, Sergey A. Kovalenko, Nikolaus P. Ernsting,*,
 

Summary:  complement (abasic site analogue opposite coumarin) in pH 7, 100 mM sodium phosphate buffer. Figure 1 shows... with the complex DNA structure surrounding the reaction site. Charge transfer between DNA bases is one example

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
65 Excavating an Active Site: The Nucleobase Specificity of Ribonuclease A Bradley R. Kelemen,, L. Wayne Schultz,,| Rozamond Y. Sweeney, and Ronald T. Raines*,,
 

Summary:  Excavating an Active Site: The Nucleobase Specificity of Ribonuclease A Bradley R. Kelemen,,§ L... pyrimidine nucleotides. When bound in the active site, the base of a pyrimidine nucleotide forms hydrogen... of the pyrimidine nucleobase with a particular active-site residue: Thr45 (8). This threonine residue, which is con

  

Source: Raines, Ronald T. - Departments of Biochemistry & Chemistry, University of Wisconsin at Madison

 

Collection: Chemistry ; Biology and Medicine

 
66 Invited Review Biologically Relevant Chemical Reactions of
 

Summary:  + AN reaction (68). The abasic sites (15) resulting from depu- rination are both toxic and mutagenic (12, 69, 70... ). Abasic sites exist (71) predominantly as the cyclic acetal 15, Scheme 3 Scheme 4 Scheme 5 Scheme 6... to the carbonyl residue in the aldehydic form of the abasic ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
67 A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with
 

Summary:  and abasic sites (30, 31). This enzyme is primarily respon- sible for inserting dC residues opposite abasic... such on the template that Rev1 has to insert one dCMP opposite a template guanine prior to encountering the abasic site... (Fig. 1A). Remarkably, at 75 mM NaCl Rev1 is ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
68 Berkeley Lab Accident Statistics Through April 30, 2009
 

Summary:  09 #12;8 Berkeley Lab Site-Wide TRC & DART Rates (Includes all Construction and Service Contractors... Berkeley Lab Site Accident Rates 5.70 4.95 3.79 2.92 2. 93 3.27 3.63 2.44 2.17 2.51 1.17 1.81 1.28 1.65 1... Fiscal Year Casesper200,000hoursworked Site Total Recordable Case Rate Site DART (Days Away, ...

  

Source: Lawrence Berkeley National Laboratory, High Redshift Supernova Search

 

Collection: Physics

 
69 Berkeley Lab Accident Statistics Through September 30, 2009
 

Summary:  Lab Site-Wide TRC & DART Rates (Includes all Construction and Service Contractors) Through September... , Restricted or Transferred) TRC Goal DART Goal 1.17 #12;8 LBNL vs DOE Contractor Rates Berkeley Lab Site... ,000hoursworked Site Total Recordable Case Rate Site DART (Days Away, Restricted, Transferred) ...

  

Source: Lawrence Berkeley National Laboratory, High Redshift Supernova Search

 

Collection: Physics

 
70 Berkeley Lab Accident Statistics Through March 31, 2009
 

Summary:  09 #12;9 Berkeley Lab Site-Wide TRC & DART Rates (Includes all Construction and Service Contractors... Berkeley Lab Site Accident Rates 5.70 4.95 3.79 2.92 2. 93 3.27 3.63 2.44 2.17 2.51 1.17 1.81 1.28 1.65 1... Fiscal Year Casesper200,000hoursworked Site Total Recordable Case Rate Site DART (Days Away, ...

  

Source: Lawrence Berkeley National Laboratory, High Redshift Supernova Search

 

Collection: Physics

 
71 NIST NCSTAR 1-5D (Draft) Federal Building and Fire Safety Investigation of the
 

Summary:  Study Team went to the site and began their assessment. This was to be a brief effort, as the study team... and the Advisory Committee. NIST maintained a publicly accessible Web site during this Investigation at http... ://wtc.nist.gov. The site contained extensive information on the background and progress of the Investigation. ...

  

Source: National Institute of Standards and Technology (NIST), Ceramics Division

 

Collection: Materials Science

 
72 DNA Repair 1 (2002) 645659 The S. cerevisiae Mag1 3-methyladenine DNA glycosylase
 

Summary:  ) pathway by removing damaged bases to create abasic apurinic/apyrimidinic (AP) sites that are subsequently... G lesions into cytotoxic abasic sites or other downstream BER in- termediates [32,33]. Another mechanism... known. Uncleaved abasic sites inhibit DNA ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
73 Molecular basis for discriminating between normal and damaged bases by the human alkyladenine
 

Summary:  be distinguished from normal DNA bases in the enzyme active site. Mutational analyses of residues contacting... , and the resulting abasic nucleotide is excised and replaced with a normal nucleotide by the sequential action... , the pyrrolidine abasic nucleotide (pyr; PDB ID code 1bnk; refs. 15 and 16). In the AAG pyr-DNA complex, ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
74 Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss-and ds-polynucleotidesq,qq
 

Summary:  single stranded regions and abasic sites in some naturally occurring RNA.51 ­ 53 Comparing the ss... and the cyclic analogue 3 bind to ss-RNA by bis-intercalation. Due to it's shorter linker 1 exhibits mono... on the base composition and tertiary structure of ds-DNA and RNA. The cyclic analogue 3 binds to ...

  

Source: Cudic, Predrag - Department of Chemistry and Biochemistry, Florida Atlantic University

 

Collection: Chemistry

 
75 J. Am. Chem. SOC.1990, 112, 2435-2437 2435 Table 1. Best Fits to Hg-MerR EXAFS"
 

Summary:  is the nature of the covalent linker. Based on mod- el-building studies, an abasic deoxyribose analogue5... -TAtriplets;" the design of nonnatural bases for completion of the triplet code; the incorporation of abasic residues... strands of the D N A duplex site in opposite orientation. Each subunit of the ...

  

Source: Stoltz, Brian M. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collection: Chemistry

 
76 Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction1
 

Summary:  at a defined position in the oligonucleotide), processing of the abasic site, incorporation of the new... ) and processing of the resulting abasic site by AP endonuclease. These activities were measured as percent... of oligonucleotide containing the lesion of interest at a defined site ...

  

Source: Stuart, Jeffrey A. - Department of Biological Sciences, Brock University

 

Collection: Biology and Medicine

 
77 PACIFIC JOURNAL OF MATHEMATICS Vol. 208, No. 1, 2003
 

Summary:  )/Tor be a cohomology class such that cF 1 (PN )=c SW(PN ) = 0.(10) Then c is called an a-basic class (where the "a... " stands for averaged). We have the following inclusions: A(N) = (a-basic classes) (basic classes... )F (monopole classes)F (11) = C(N)F . We want to relate now a-basic classes with the SW function SW(N): Let c

  

Source: Vidussi, Stefano - Department of Mathematics, University of California at Riverside

 

Collection: Mathematics

 
78 Supplementary Material Comparative chemometric and QSAR/SAR study of structurally
 

Summary:  structures without hydrogen bonding: DNA with pyrene paired at abasic sites. Nucl. Acids Res. 30 (2002) 5561... without hydrogen bonding: DNA with pyrene paired at abasic sites. Nucl. Acids Res. 30 (2002) 5561-5569. 1... chloramphenicol analogues revealed by ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
79 Nucleic Acids Research, 2007, 112 doi:10.1093/nar/gkm674
 

Summary:  of a substrate analogue that includes a deoxyriboadenine adjacent to the cleavage site prevents the cleavage from... of the SdA4 analogue as indicated by the symbols (À) and (+), respectively. The sites of RNase T1 hydrolyses... file. RNA synthesis and 32 P-5'-end labelling Chemical synthesis. The ...

  

Source: Perreault, Jean-Pierre - Département de biochimie, Université de Sherbrooke

 

Collection: Biology and Medicine

 
80 Enzyme-Activated, Hypoxia-Selective DNA Damage by 3-Amino-2-quinoxalinecarbonitrile 1,4-Di-N-oxide
 

Summary:  and catalyzes strand cleavage at the result- ing abasic site (31-33). We find that treatment of the damaged DNA... of the damaged DNA with the enzyme endo IV, which catalyzes strand cleavage at abasic sites and oxidized abasic... to excision of oxidized base lesions and not the enzyme's ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry


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81 Guidelines for Research Studies in the Emergency Department A primary goal of the Arizona Emergency Medicine Research Center (AEMRC) is to
 

Summary:  of Emergency Department and AEMRC expenses. Obtain site authorization for the study from the AEMRC. Prior... and will include at least 10 patients. Core cost calculations are abased on 45 minutes per 15 participating

  

Source: Arizona, University of - Center for Gamma-Ray Imaging

 

Collection: Engineering ; Biology and Medicine

 
82 HyperStorM -Administering Structured Documents Using Object-Oriented Database Technology
 

Summary:  the conventional notion of `document,'. - Document components' semantics should be available within the dat,abase... at the server site: transformation of docu- me~ts might not be straightforward, hut may instead be driven

  

Source: Aberer, Karl - Faculté Informatique et Communications, Ecole Polytechnique Fédérale de Lausanne

 

Collection: Computer Technologies and Information Sciences

 
83 Chemistry & Biology, Vol. 12, 357369, March, 2005, 2005 Elsevier Ltd All rights reserved. DOI 10.1016/j.chembiol.2004.12.011 Delineation of the Chemical Pathways Underlying
 

Summary:  double-strand breaks by direct reaction with DNA [32, 34, 35]. How- ever, base lesions, abasic sites... breaks, abasic sites, and base lesions induced and effective measure of recombination at a single lo... , abasic sites, and single- strand breaks. To gain a better ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
84 The University of Western Ontario DEPARTMENT OF PHYSICS AND ASTRONOMY
 

Summary:  planets and describe some of his research at analogue sites in the Canadian Arctic. He will also provide... the concept of terrestrial analogues: these are places on Earth that approximate the geological, environmental... will provide an introduction to the use of terrestrial analogues to further our ...

  

Source: Lennard, William N. - Department of Physics and Astronomy, University of Western Ontario

 

Collection: Materials Science ; Physics

 
85 ARTICLE IN PRESS An investigation of the variation in the transition bias among various
 

Summary:  . Oxygen free radicals have at least two mutagenic effects: (i) they generate abasic sites (Schaaper et al... -generation of abasic sites-is expected to affect the ts/tv ratio because DNA polymerases tend to incoporate A opposite... abasic sites; if the ...

  

Source: Eyre-Walker, Adam - Department of Biology and Environmental Science, University of Sussex

 

Collection: Biology and Medicine

 
86 Formation of DNA-Protein Cross-Links Between -Hydroxypropanodeoxyguanosine and EcoRI
 

Summary:  of an abasic site cross-linked to the catalytically active N-terminal threonine of T4 PDG and the imine... with abasic site-containing DNA. J. Mol. Biol. 362, 241­ 258. (35) Liu, W., Chen, Y., Watrob, H., Bartlett, S... -link to EcoRI was dependent on the intimate binding of the enzyme to its -HOPdG-modified ...

  

Source: Marnett, Lawrence J. - Department of Chemistry, Vanderbilt University

 

Collection: Biology and Medicine ; Chemistry

 
87 ANRV260-GE39-03 ARI 21 June 2005 22:14 Immunoglobulin Gene
 

Summary:  , abasic endonucleases nick the phosphodi- ester backbone at the abasic site, DNA poly- merase synthesizes... the phosphodiester backbone at the abasic site, and DNA polymerase and ligases repair the gap. AID Deaminates Single... is the fate of the abasic ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
88 TETRAHEDRON Tetrahedron Letters 42 (2001) 67796783Pergamon
 

Summary:  ,2 or to abasic sites of DNA3 or those that can selectively interact with single-stranded (ss-) RNA sequences4... kinetics of macrocyclic bis-acridinium analogues,11 all titrations were performed in a way... change than the G-C analogue; also there is an obvious difference in fluorescence response between RNA ...

  

Source: Cudic, Predrag - Department of Chemistry and Biochemistry, Florida Atlantic University

 

Collection: Chemistry

 
89 Equivariant cohomology and the Cartan model
 

Summary:  = ker(), the invariant sub- algebra Ag = ker(L), and the basic subalgebra Abasic = Ahor Ag . Note... ) principal bundles, with Abasic playing the role of the base of the principal bundle. 4. Weil algebra... The Weil algebra Wg is the algebraic analogue to the classifying bundle EG. Similar to EG, it may

  

Source: Meinrenken, Eckhard - Department of Mathematics, University of Toronto

 

Collection: Mathematics

 
90 Synthesis of a Novel Coumarin C-Riboside as a Photophysical Probe of
 

Summary:  opposite to an abasic site analogue. The photophysical properties of 1 will be critical to its proposed... .6 Molecular modeling of this C-glycoside system posi- tioned opposite to an abasic model7 within

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
91 Brandt F.Eichman1 , Eyleen J.O'Rourke1,2
 

Summary:  -type and mutant MagIII enzymes for duplex DNAs containing a 1-azaribose abasic (AP) site were measured by a ¯uores... to crystal and NMR structures of the unliganded enzymes and com- plexes with abasic DNA inhibitors. Presented... . These are the ®rst structures of a nucleobase bound in the active site of a ...

  

Source: Eichman, Brandt F. - Department of Biological Sciences, Vanderbilt University

 

Collection: Biology and Medicine

 
92 ARBEITSGRUPPEN DEPARTEMENT FR CHEMIE UND BIOCHEMIE
 

Summary:  Stable, Functional Abasic Site Analogue, Org. Lett., 2005, 7, 5211-5214. PROF. S. LEUTWYLER 126... : Remarkable Stabilization of Duplex DNA Containing an Abasic Site by Non-Nucleosidic Phenanthroline and Pyrene... Res., 2005, 33, e77. 123. P. A. Küpfer, C. J. Leumann, RNA ...

  

Source: Mühlemann, Oliver - Institut für Zellbiologie, Universität Bern

 

Collection: Biology and Medicine

 
93 MOLECULAR AND CELLULAR BIOLOGY, Sept. 2002, p. 64806486 Vol. 22, No. 18 0270-7306/02/$04.00 0 DOI: 10.1128/MCB.22.18.64806486.2002
 

Summary:  endonuclease activity and functions in the removal of abasic sites from DNA. Here, we provide evidence... - ified miscoding bases, abasic (AP) sites, and DNA strand breaks. AP sites are some of the most common... tetrahydrofuran, an abasic site ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
94 Conformational Analysis of DNA Repair Intermediates by Time-Resolved Fluorescence Spectroscopy
 

Summary:  the fluorescent reporter 2-aminopurine (2AP) at the modification site. The 2AP analogue is an attractive probe... and dynamics of abasic lesions and single-base mismatches,3 no systematic analysis of other DNA repair... near 2AP becomes more disordered as the extent of damage increases to the modified site. ...

  

Source: Szostak, Jack W. - Department of Genetics, Harvard University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
95 Binding Analogue Feedback to Digital Genomes: Bio-inspired Regulatory Control for Analogue Devices
 

Summary:  Binding Analogue Feedback to Digital Genomes: Bio-inspired Regulatory Control for Analogue Devices... @cs.york.ac.uk Abstract: We propose a bio-inspired control mechanism for dynamically programmable analogue devices. Our... and configuration of (potentially many) analogue circuits. Most solutions in ...

  

Source: Stepney, Susan - Department of Computer Science, University of York (UK)

 

Collection: Computer Technologies and Information Sciences

 
96 Berkeley Lab Accident Statistics Through February 28, 2009
 

Summary:  Construction LBNL Service Subcontractors Division Number of Cases FY07 FY08 FY 09 #12;8 Berkeley Lab Site... Goal DART Goal 1.17 #12;9 LBNL vs DOE Contractor Rates Berkeley Lab Site Accident Rates 5.70 4.95 3... 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 Fiscal Year Casesper200,000hoursworked Site

  

Source: Lawrence Berkeley National Laboratory, High Redshift Supernova Search

 

Collection: Physics

 
97 Oxidative DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)
 

Summary:  (endo IV), and abasic sites (exo III and endo IV) into strand breaks (Fig. 1).23,25,26 The base excision... duplex DNA (Fig. 1) and also catalyze subsequent strand clea- vage at the resulting abasic site (Scheme 2... that abasic sites and/or C10 -oxidized ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
98 Nitrosative Cytosine Deamination. An Exploration of the Chemistry Emanating from Deamination with
 

Summary:  possibilities are described in Figure 2. Cation 6 could undergo hydrolytic deglycation forming an abasic site... observed. Cyclization of the Benzo-Analogue: Preparation of Ethyl (Z)-2-Cyanophenylcarbamate 14 and its... methyltrans- ferases are unlikely to be the major cause of mutational hot spots at sites ...

  

Source: Glaser, Rainer - Department of Chemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
99 Berkeley Lab Accident Statistics Through June 30, 2009
 

Summary:  09 #12;8 Berkeley Lab Site-Wide TRC & DART Rates (Includes all Construction and Service Contractors... Berkeley Lab Site Accident Rates 5.70 4.95 3.79 2.92 2.93 3.27 3.63 2.44 2.17 2.51 1.17 1.81 1.28 1.65 1... Fiscal Year Casesper200,000hoursworked Site Total Recordable Case Rate Site DART (Days Away, ...

  

Source: Lawrence Berkeley National Laboratory, High Redshift Supernova Search

 

Collection: Physics

 
100 Berkeley Lab Accident Statistics Through July 31, 2009
 

Summary:  ;8 Berkeley Lab Site-Wide TRC & DART Rates (Includes all Construction and Service Contractors) Through July 31... , Restricted or Transferred) TRC Goal DART Goal 1.17 #12;9 LBNL vs DOE Contractor Rates Berkeley Lab Site... ,000hoursworked Site Total Recordable Case Rate Site DART (Days Away, Restricted, ...

  

Source: Lawrence Berkeley National Laboratory, High Redshift Supernova Search

 

Collection: Physics


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