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Sample search results for: abc drug transporters

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1 Applied Mathematics Letters 24 (2011) 12511256 Contents lists available at ScienceDirect
 

Summary:  to trigger the induction of ATP-Binding Cassette (ABC) transporters, responsible for the efflux of the drug... promote ABC transporter expression. The enhanced active efflux results in a decreased intracellular drug... to completely inhibit ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine

 
2 Nederlandse samenvatting Nederlandse samenvatting voor genteresseerden buiten
 

Summary:  vakgebied Samenvatting ABC transporters zijn eiwitten die betrokken zijn bij de opname van voedingsstoffen... en uitscheiding van schadelijke stoffen in de biologische cel. Defecten in ABC transporters kunnen... bij de mens ernstige ziektes tot gevolg hebben. Te grote activiteit van ABC ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
3 List of publications 1. Poelarends, G.J., Mazurkiewicz, P., Putman, M., Cool, R.H., van Veen,
 

Summary:  .W., and Konings, W.N. (2000). An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally... a heterodimeric ABC- type multidrug transporter. Accepted to J. Biol. Chem. 7. Mazurkiewicz, P., Driessen, A... broad substrate specificity. Drug Resist. Updat., 3, ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
4 Genome Biology 2004, 5:R15 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation
 

Summary:  commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation Open Access2004Shepset al.Volume 5, Issue 3, Article R15Research The ABC transporter gene family... purpose, provided this notice is preserved along with the article's original URL. The ABC transporter gene... severalgene families ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
5 ABC transporters ABC transporter architecture and regulatory roles of
 

Summary:  ABC transporters 9 Chapter 2 ABC transporter architecture and regulatory roles of accessory domains... of the architecture of ABC transporters and dissect the systems in core and accessory domains. The ABC transporter... ). ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
6 LmrCD is a major MDR transporter in Lactococcus lactis
 

Summary:  . The ABC (20 genes) and MFS transporters (18 genes) are the most abundant types of drug transporters, while... .g. as a result of various stress responses The L. lactis lmrCD is hypersensitive to drugs The two ABC half-transporters... were ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
7 2009-taebc ABC-Clio ebooks collection 1203titles ISBN URL
 

Summary:  2009-taebc ABC-Clio ebooks collection 1203titles ISBN URL 1 Arts & Humanities Acquisitions... Bastian, Jeannette Allis Libraries Unlimited Ebooks 2003 http://ebooks.abc- clio.com/?isbn=9780313052378 2... Libraries Unlimited Ebooks 2007 http://ebooks.abc- clio.com/?isbn=9780313094521 3 Arts & Humanities

  

Source: Wu, Yih-Min - Department of Geosciences, National Taiwan University

 

Collection: Geosciences

 
8 Introduction to multidrug transporters, cellular resistance and lantibiotic production in Lactococcus lactis
 

Summary:  -binding cassette (ABC) superfamily of primary transporters that hydrolyse ATP to drive drug secretion. The major... define the function of the lactococcal multidrug transporters LmrA and LmrP in cellular drug resistance... , and of the ABC ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
9 SPECIALSPECIAL CENTENNIALCENTENNIAL SYMPOSIA:SYMPOSIA: P450s: Structure, Function, In Silico Predictions
 

Summary:  Woolverton ABC Transporters: From Drug Resistance to Drug Response Spkrs: Erin Schuetz, Alfred Schinkel... Challenges Spkrs: Matthias Tschop, Francis Kuhajda, Stephen Bloom, Xavier Pi-Sunyer, David Weigle Drug... for Drug Abuse: The Cocaine Challenge Spkrs: Kenneth ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
10 PROTEIN INTERACTIONS AND DISEASE PHENOTYPES IN THE ABC TRANSPORTER SUPERFAMILY
 

Summary:  PROTEIN INTERACTIONS AND DISEASE PHENOTYPES IN THE ABC TRANSPORTER SUPERFAMILY LIBUSHA KELLY1... Francisco, CA 94158, USA. ABC transporter proteins couple the energy of ATP binding and hydrolysis... known ABC transporters in diseases such as cystic fibrosis and ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
11 What do the proton motive force-driven multidrug resistance transporters have in common?
 

Summary:  cells can use MDR transporters to fight the cytotoxic action of drugs. Currently, several MDR extrusion... of multidrug recognition and the transport mechanisms will allow a more rational design of new drugs which... Drug Resistance (SDR) transporters. In contrast, ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
12 Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes in
 

Summary:  Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes... , BC Canada V5Z 1L6 We have previously identified 60 predicted ABC transporter genes... region for a neighbouring gene. q 2004 Elsevier Ltd. All rights reserved. Keywords: ABC ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
13 Summary and concluding ESEARCH on the structure and function of substrate-binding proteins (SBPs)
 

Summary:  -binding proteins (SBPs) of ATP Binding Cassette (ABC) transporters has been ongoing for at least four decades. Our... on the lactococcal oligopeptide binding protein A (OppA), the receptor component of the ABC-transporter oligopeptide... cycle of ABC-transporters. In recent years, the field has taken several ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
14 Summary and concluding remarks Summary and concluding remarks
 

Summary:  the secondary transporter LmrP depends on the proton motive force to expel a range of drugs, while the ATP... -binding cassette (ABC) transporters LmrA (3) and LmrCD (2) use the free energy derived from ATP hydrolysis... for the intrinsic multidrug resistance in L. lactis. These are ABC ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
15 Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance
 

Summary:  as a result of alterations in an unusual adenosine transporter involved in the uptake of these drugs. African... adenosine/adenine/drug transporter is altered in a way that leads to a diminished accumulation of drug... transporter are al- ways associated with the ...

  

Source: Fairlamb, Alan - Division of Biological Chemistry and Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine

 
16 Bock et al. 2006 Family Summary 1.A.1 Voltage-gated Ion ChannVIC 36 34 2
 

Summary:  homolog, ABC transporter WBC 26 26 982 3.A.1.205 Pleiotropic Drug ResistancABC 143 pleiotropic drug... resistance ABC transporter PDR 15 11 1008 3.A.1.205 Pleiotropic Drug ResistancABC 157 putative ...

  

Source: Sze, Heven - Department of Cell Biology and Molecular Genetics, University of Maryland at College Park

 

Collection: Biology and Medicine

 
17 List of Abbreviations Acknowledgments
 

Summary:  sulfoxide DTs drug transporters DTT dithiothreitol EtOH ethanol FGF fibroblast growth factor FGFR fibroblast... ;Appendix 186 List of Abbreviations 1,25(OH)2D3 1,25-dihydroxyvitamin D3 ABC ATP-binding cassette ASBT... apical sodium dependent bile acid transporter BAs bile acids BIS-I bisindolyl maleimide I ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
18 Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.106.066720
 

Summary:  Accepted for publication December 24, 2006 ABSTRACT ABC transporters constitute one of the largest gene... -binding cassette (ABC) transporter proteins con- stitute one of the largest protein families in both prokaryotes... acids into the cell. In eukaryotes, the majority of ABC ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
19 EFFLUX TRANSPORTERS: Newly Appreciated
 

Summary:  ­384. (26) Scotto, K. W. Transcriptional Regulation of ABC Drug Transporters. Oncogene 2003, 22, 7496... transporter proteins belonging to the adenosine triphosphate (ATP)-bindingcassette(ABC... EntAl SCiEnCE & tEChnology / JunE 1, 2008 #12;(hence, ABC ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
20 Function of prokaryotic and eukaryotic ABC proteins in lipid transport Antje Pohla,b
 

Summary:  Review Function of prokaryotic and eukaryotic ABC proteins in lipid transport Antje Pohla... of the ABC protein families A, B, C, D and G are mutated in a number of lipid transport and metabolism... and further transport to specific sites. Additionally, lipid ...

  

Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques

 

Collection: Chemistry ; Biology and Medicine


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21 Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression
 

Summary:  for the transport of drugs and other xenobiotics. ABC transporters are efflux pumps that rely on ATP hydrolysis... to actively move substrates across biological membranes [1,2]. In the ABC transporter superfamily, drug... and ...

  

Source: 

 

Collection: Biology and Medicine ; Biotechnology

 
22 10.1110/ps.051998406Access the most recent version at doi: 2006 15: 1597-1607Protein Sci.
 

Summary:  and functional characterization of human ABC transporter ABCG2 variants in insect cells. Drug. Metab. Pharma... members of the ATP-binding cassette (ABC) transporter superfamily, including P-glycoprotein and the half-transporter... recognition and binding. Keywords: ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
23 General Introduction Chapter 1: General Introduction
 

Summary:  -dependent primary transporters 21 4.1: The ABC superfamily portrait 21 4.2: The substrate-binding domain 22 4... -dependent transporters 27 5.1: Substrate binding 28 5.2: Functional interactions in the binding protein-dependent 30 ABC... -hydrolysis (Fig. 1c). These proteins are members of the ATP-binding ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
24 General introduction I. General features of cell volume control
 

Summary:  .g. the multiple-drug resistance (MDR) transporters. Well-studied ABC-type efflux systems are the human multidrug... to an osmotic upshift are substrate-binding protein-dependent ABC transporters, which use ATP as source... of the system for another transport cycle. ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
25 Introduction EG van de Kerkhof
 

Summary:  of the intestine, are able to metabolize and transport endogenous and exogenous compounds [4-7]. Drug metabolism... and transporters in the intestinal tract Although the liver has long been thought to play the major role in drug... knowledge concerning appreciation of drug metabolizing ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
26 Functional hot spots in human ATP-binding cassette transporter
 

Summary:  , Locher KP (2007) Structure of the multi- drug ABC transporter Sav1866 from Staphylococcus aureus... (ABC) transporter superfamily consists of 48 integral membrane proteins that couple the action of ATP... of the majority of ABC transporter ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
27 Multidrug and peptide export in Lactococcus lactis
 

Summary:  transport by the ABC transporter LmrA of Lactococcus lactis 35 Chapter 4 Effect of the calcium channel... blocker verapamil on drug extrusion and resistance mediated by the multidrug resistance protein Lmr... C and the transporter NisT to prenisin production by Lactococcus lactis 63 ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
28 Discussion and concluding remarks General introduction
 

Summary:  transporters are the low-resolution structures of the human multi-drug resistance (MDR) ABC transporters P... activated transporters. A detailed study of the osmoregulated ATP- binding cassette (ABC) transporter Opu... into the mechanism rooting ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
29 A genomic survey of the distribution of ABC-transporters in the hyperthermophilic archaeal Pyrococcus species
 

Summary:  Chapter 5 1 A genomic survey of the distribution of ABC-transporters in the hyperthermophilic... of ABC-transport systems. Of the seventeen to nineteen ABC-transporters present per species, eight... , phosphoenolpyruvate (PEP)- dependent phosphotransferase systems (PTS), and ATP-binding cassette (ABC-) ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 nAture methods | VOL.8 NO.2 | FEBRUARY2011 | 159 Phenotypes that might otherwise reveal a gene's function
 

Summary:  - ceuticals. For example, ATP-binding cassette (ABC) transporters overlap in the drugs they export. To isolate... for characterizing exogenous transporters7. However, the two ABC transporter gene clades implicated in drug efflux... for other ...

  

Source: Harvard University, Center for Cancer Systems Biology; Roth, Frederick - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine ; Biotechnology

 
31 COMPARATIVE MEDICINE LABORATORY ANIMAL FACILITIES
 

Summary:  SUPERVISION DURING TRANSPORTATION AND STORED IMMEDIATELY IN A DEPARTMENT SAFE OR CONTROLLED DRUG CABINET... for CONTROLLED DRUG PROCUREMENT 1.0 Purpose This procedure provides instruction to anyone wishing to purchase... a whole bottle(s) of controlled drug under the CMLAF DEA license number 2.0 Scope This ...

  

Source: Krovi, Venkat - Department of Mechanical and Aerospace Engineering, State University of New York at Buffalo

 

Collection: Engineering

 
32 drug discovery drug discovery
 

Summary:  drug discovery at Purdue #12;drug discovery 2 #12;drug discovery 3 Introduction The drug discovery... and innovative drug candidates to treat chronic and acute illnesses. Our researchers also continue to be invested... in various approaches to drug discovery, which ...

  

Source: Purdue University, Department of Forestry and Natural Resources, Human-Environment Modeling and Analysis Laboratory

 

Collection: Environmental Sciences and Ecology

 
33 doi:10.1006/scdb.2001.0250, available online at http://www.idealibrary.com on seminars in CELL & DEVELOPMENTAL BIOLOGY, Vol. 0, 2001: pp. 110
 

Summary:  of the ABC domains of one half of the transporter is coupled to drug efflux, operating similarly to a two... cassette (ABC) superfamily of membrane transporters. This review focuses on the use of structure... -gp transporter pump may reduce intracellular ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
34 Aquatic Animal Drug Approval Partnership: In Pursuit of Aquaculture Drug Approvals Legal and Judicious
 

Summary:  animals treated with the drug ­ Permits the legal interstate transport of the drug Aquatic Animal Drug... Aquatic Animal Drug Approval Partnership: In Pursuit of Aquaculture Drug Approvals Legal... and Judicious Use of Drugs and Therapeutants in ...

  

Source: Southern Illinois University, Fisheries and Illinois Aquaculture Center

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
35 Introduction General introduction
 

Summary:  . Furthermore, it includes genes encoding a dedicated ABC-transporter and an accessory protein (except... -binding cassette (ABC) transporters and their accessory proteins, or by the general sec-dependent secretory pathway... a specific transport system (Håvarstein et al., 1995; Franke et al., 1996). The ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
36 Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric Dimers
 

Summary:  Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric... of the ATP binding cassette (ABC) transporter superfamily, is overexpressed in numerous multidrug... were expressed at the plasma membrane and maintained drug ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
37 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap-
 

Summary:  or cellular efflux of drugs. Transporters play an important role in drug disposition as drugs can only... be metabolized after they are transported into the liver cells. However, transporter-based drug interactions... expand our approach to in- ...

  

Source: Baral, Chitta - Department of Computer Science and Engineering, Arizona State University

 

Collection: Computer Technologies and Information Sciences

 
38 Epilepsia, **(*):110, 2007 Blackwell Publishing, Inc.
 

Summary:  of these sequences share known ABC transporter motifs, as shown in Fig. 4. DISCUSSION Drug resistance in epilepsy... : Background: Multidrug transporters are postulated to contribute to antiepileptic drug (AED) resistance... . The trans- porter best studied is P-glycoprotein, an ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
39 [CANCER RESEARCH 61, 66356639, September 15, 2001] Advances in Brief
 

Summary:  transporter mdr1a/1b (9). Studies in drug-resistant cells with overexpression of MXR/BCRP/ABCP show... /BCRP/ABCP-mediated drug transport (13). The cells were then washed with ice-cold complete media and either placed on ice... ; this is one of the first examples of an ABC ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
40 Chapter 1 An introduction to adenine nucleotidebinding proteins Adenosine triphosphate
 

Summary:  binding cassette (ABC) transport ATPases has been the focus of this thesis and these proteins... through ligandgated ion channels [16]. Transport ATPases The P, V and FATPases together with the ABC... of an electrochemical ion gradient [19]. The class of ABC ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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41 PharmGKB Submission Update: IV. PMT Submissions of Genetic Variations in ATP-
 

Summary:  into these restricted sites. The overexpression of some ABC transporters is associated with drug resistance in tumors... . Pharmacological Significance: ABC transporters are expressed in the basolateral (blood-facing) or api- cal (lumen... of ABC ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
42 In vitro methods to study intestinal drug metabolism
 

Summary:  compounds. Furthermore, the relevance of drug transporters in this process has been proven. Only a few... . Their applicability to study phase I-III metabolism/transport and drug-drug interactions in various species... for studying overall drug metabolism and interactions with ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
43 Candida Drug Resistance Protein 1, a Major Multidrug ATP Binding Cassette Transporter of Candida albicans, Translocates Fluorescent Phospholipids in a
 

Summary:  . Overexpression of the multidrug transporter Cdr1p (Can- dida drug resistance protein 1), a member of the ABC1... the transport of substrates across membranes. Also, like most ABC drug transporters, Cdr1p is promiscuous in its... Candida ...

  

Source: Menon, Anant K. - Menon Lab, Weill Medical College, Cornell University

 

Collection: Biology and Medicine

 
44 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  transporters that block the passage of drugs across the blood- brain barrier. The three most prevalent ATP... in cytotoxicity of drugs effluxed at each transporter. Accumulation of [3 H]dLop was lowest in cells... -gp. Efflux transporters of the ATP-binding cassette ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
45 Department of Botany, 3359 Mississauga Road
 

Summary:  | Antifungal-drug-resistance mechanisms Increased efflux Overexpression of ABC (ATP-binding cassette... of the ABC transporters and the alteration in sterol synthesis caused by loss of function at ERG3 REF. 12... EVOLUTION OF ANTIFUNGAL DRUG RESISTANCE: MECHANISMS AND PATHOGEN FITNESS ...

  

Source: Anderson, James B. - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collection: Environmental Sciences and Ecology

 
46 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  transporters that block the passage of drugs across the blood- brain barrier. The three most prevalent ATP... in cytotoxicity of drugs effluxed at each transporter. Accumulation of [3 H]dLop was lowest in cells... -gp. Efflux transporters of the ATP-binding cassette ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
47 Medicines By Design U.S. DEPARTMENT OF
 

Summary:  of Health and Human Services #12;10 20 30 40 50 Contents FOREWORD: A VISIT TO THE DOCTOR 2 CHAPTER 1: ABCS... OF PHARMACOLOGY 4 A Drug's Life 5 Perfect Timing 9 Fitting In Bench to Bedside: Clinical Pharmacology 13... Gain Our Immune Army 23 A Closer Look 26 CHAPTER 3: DRUGS FROM NATURE, THEN AND NOW 28 Nature

  

Source: Bezrukov, Sergey M. - Laboratory of Physical and Structural Biology, National Institute of Child Health and Human Development

 

Collection: Chemistry ; Biology and Medicine

 
48 Proton motive force-dependent Hoechst 33342-transport by the ABC transporter LmrA of Lactococcus lactis
 

Summary:  transporter that is highly active in drug excretion (4). Both systems are ABC transporters, and their activity... 35 Chapter 3 Proton motive force-dependent Hoechst 33342-transport by the ABC transporter Lmr... constructed mutants of the adenosine ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
49 Annu. Rev. Pharmacol. Toxicol. 1999. 39:36198 BIOCHEMICAL, CELLULAR,
 

Summary:  for the proper functioning of P-gp, including drug transport (16). Although a number of experimental approaches... , but it is not functional for either transport or drug-stimulated ATPase activity (32). Furthermore, replacement of the dele... transporter and that the major ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
50 Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic
 

Summary:  are mediated by transport proteins, which can be specific for a given drug or class of drugs, or can handle... and the transport activities of the mutant proteins were measured as the excretion of the cationic drugs ethidium... to be useful drugs to study the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
51 List of non-standard abbreviations ABC: ATP-binding cassette
 

Summary:  Appendix 200 List of non-standard abbreviations ABC: ATP-binding cassette ACN: Acetonitril Ah... 450 D: Duodenum DEX: Dexamethasone DME: Drug metabolizing enzyme DMSO: Dimethylsulfoxide DT: Drug... transporter DTT: Dithiothreitol EpRE: Electrophile responsive element FCS: Fetal calf serum GR: Glucocorticoid

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
52 Summary and outlook H. Bart van den Berg van Saparoea and Arnold J.M. Driessen
 

Summary:  C and lmrD (4;5;7). LmrA is an ABC half transporter that is thought to function as a homodimer. LmrC and Lmr... D are ABC half transporters that function as a heterodimer, while LmrP belongs to the major facilitator... A deletion strain exhibits an altered susceptibility to heavy metals. The ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
53 Molecular & Biochemical Parasitology 130 (2003) 8390 Functional genetic identification of PRP1, an ABC transporter superfamily
 

Summary:  , an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major Adriano C... -glycoprotein (PGP)/MRP ATP-binding cassette (ABC) transporter superfamily that we named pentamidine resistance... ). PRP1 is a member of the ATP-binding cassette (ABC) ...

  

Source: Beverley, Stephen M. - Department of Molecular Microbiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
54 ISSN 1741-054110.2217/PME.11.20 2011 Future Medicine Ltd PeRsPective
 

Summary:  - centrations of target molecules for the drugs and the function of active efflux transporters, the ATP... transport towards tissues Control by neurohumoral inputs and drugs onto tissues Population of individuals... plasma infusion 4. Intracellular MTHF concentration 5. FdUMP-induced factor triggering ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine

 
55 General introduction General introduction
 

Summary:  compounds from the cell (55). ABC transporters involved not only in drug export but also in a variety... the introduction of combined chemotherapy (19,67). P-gp is a transport protein that expels drugs from the cell thus... of defense and one of the most common mechanisms is the active ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
56 Structure and Dynamics of Large Biological Molecules: ATP-Binding Cassette (ABC) Transporters
 

Summary:  Structure and Dynamics of Large Biological Molecules: ATP-Binding Cassette (ABC) Transporters Jung... . ABC transporters are membrane proteins that actively transport substrates through lipid bilayers4... helices. Selective uptake and efflux by ABC ...

  

Source: Jones, R. O.- Institut für Festkörperforschung, Forschungszentrum Jülich

 

Collection: Materials Science

 
57 Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
 

Summary:  -binding cassette (ABC) transporter knockout (KO) animals may facilitate the identification of common substrates... between apparently unrelated ABC transporters. An unexpectedly low concentration of the purine nucleotide... of the Mrp4 KO mouse prompted us to evaluate the possibility that Abcg2 might ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
58 Mapping of Interdomain Interfaces Required for the Functional Architecture of Yor1p, a Eukaryotic ATP-binding
 

Summary:  ABC transporter, Yor1p, which functions as a pleiotropic drug pump at the plasma mem- brane. We have... for human health because ABC transporters play roles in drug resistance, ion transport, and other... ATP-binding Cassette ...

  

Source: Miller, Liz - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
59 Multifunctional Micellar Nanomedicine for Cancer Therapy
 

Summary:  for interstitial transport (34). More- over, drug release from conventional liposomal formula- tions is quite... . Solubilization and controlled release of a hydrophobic drug using novel micelle-forming ABC triblock copolymers... hydrophobic drugs as well as imaging agents, and improved ...

  

Source: Gao, Jinming - Department of Oncology and Pharmacology, University of Texas Southwestern Medical Center at Dallas

 

Collection: Biology and Medicine

 
60 Drug efflux mechanism by a secondary transporter LmrP
 

Summary:  Drug efflux mechanism by a secondary transporter LmrP of Lactococcus lactis #12;Rodzicom Cover... Partners Ipskamp, Enschede #12;Rijksuniversiteit Groningen Drug efflux mechanism by a secondary transporter Lmr... and are called Specific Drug Resistance (SDR) ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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61 Concluding Remarks and Perspectives 8.1. Concluding remarks
 

Summary:  phase in the drug-rich layer, C is crystallised drug, D is the stagnant layer transporting the drug via... , the dissolution of the matrix as measured during the experiment has to be used to calculate the drug transport... from the solid dispersion to the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
62 BioMed Central Page 1 of 15
 

Summary:  administration and drug excretion are body-level events, while drug transport and enzymatic reactions... DrugMolecular Process Drugs Irinotecan Ketoconazole DrugOrMetabolite Metabolites P-gp Membrane_Transport... Research Drug ...

  

Source: 

 

Collection: Biotechnology ; Biology and Medicine

 
63 ABC transporters: Lessons from a bacterial oligopeptide uptake system
 

Summary:  ABC transporters: Lessons from a bacterial oligopeptide uptake system Mark K. Doeven #12;Cover... by PrintPartners Ipskamp, Enschede #12;RIJKSUNIVERSITEIT GRONINGEN ABC transporters: Lessons from... A determines the selectivity of the oligopeptide ABC transporter 35 ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
64 1. Teuber, M. (1995) The genus Lactococcus, in The Lactic Acid Bacteria (Wood, B. J. B. and Holzapfel, W. H., Eds.) 1 ed., pp 173-234, Blackie Academic and Professional,
 

Summary:  encodes a proton motive force- dependent drug transporter, J. Biol. Chem. 270, 26092-26098. 8... of a complete library of putative drug transporter genes in Escherichia coli, J. Bacteriol. 183, 5803-5812. 14... -deficient Streptococcus pneumoniae strain panel to identify ABC-class ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
65 Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A
 

Summary:  ABSTRACT Several ATP-binding cassette (ABC) transporters can confer multidrug resistance to cancer cells... -glycoprotein (P-gp) are two ABC transporters that, when overexpressed, are capable of extruding a variety... -gp is one of the best under- stood ABC ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
66 Multidrug and peptide export in Lactococcus lactis
 

Summary:  -binding cassette (ABC) superfamily of primary transporters that hydrolyse ATP to drive drug secretion. The major... transport by the ABC transporter LmrA of Lactococcus lactis 35 Chapter 4 Effect of the calcium channel... define the function of the lactococcal ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
67 Hop Resistance in the Beer Spoilage Bacterium Lactobacillus brevis Is Mediated by the ATP-Binding
 

Summary:  HorA protein identified HorA as a new member of the ABC family of multidrug transporters. #12;CHAPTER... bacterial multidrug resistance proteins, LmrA is an ATP-binding cassette (ABC) transporter (Higgins, 1992... of the ABC multidrug transporter LmrA in L. lactis ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
68 ABC transporters: Lessons from a bacterial oligopeptide uptake system
 

Summary:  ABC transporters: Lessons from a bacterial oligopeptide uptake system Mark K. Doeven #12;Cover... by PrintPartners Ipskamp, Enschede #12;RIJKSUNIVERSITEIT GRONINGEN ABC transporters: Lessons from... A determines the selectivity of the oligopeptide ABC transporter 35 ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
69 European Journal of Pharmaceutical Sciences 37 (2009) 106114 Contents lists available at ScienceDirect
 

Summary:  for the equilibrium amounts Q eq A/B/C and the constants (A/B/C)(1/2/3) for non-linear transporters of the Michaelis... ) 106­114 111 eral loading of the drug. Considerations of other efflux pathways in the P-gp transporter... , but an increase of ClCB decreases the characteristic time ...

  

Source: Toral, Raúl - Mediterranean Institute for Advanced Studies & Departament de Física, Universitat de les Illes Balears

 

Collection: Materials Science ; Physics

 
70 Summary and concluding remarks Microorganisms have developed multiple strategies to resist the
 

Summary:  ) active extrusion of drugs by transport proteins present in the cell membrane (Fig. 1). LmrP is one... of such transporters that extrude a wide variety of cationic drugs. It consists of 408 amino acids organized in 12... of drug target (T); C, prevention of drug ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
71 Evidence That Release of Adenosine Triphosphate From Endothelial Cells During Increased Shear Stress Is Vesicular
 

Summary:  of functioning as a channel transporting both Cl- and ATP out of the cell (29). These two ABC proteins... and the sulfonylurea receptor, another ABC transporter that is an ATP-sensitive K+ channel, have been identified... on vascular endothelial cells (12­14). However, the role of these ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
72 Effect of the calcium channel blocker verapamil on drug-extrusion and resistance mediated by the
 

Summary:  lacks the major drug transporter LmrCD, but contains a genomic copy of lmrP. Expression of lmr... is independent of the presence of added drugs. Since verapamil inhibits substrate transport by LmrP, the growth... to study the effect of this mutant on the drug resistance of cells. ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
73 Regulation of multidrug resistance in Lactococcus Herfita Agustiandari
 

Summary:  compounds from the cell (55). ABC transporters involved not only in drug export but also in a variety... ., Driessen, A. J. M. 2008. The ABC-type multidrug resistance transporter LmrCD is responsible... R is a transcriptional repressor of expression of the multidrug ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
74 This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  been shown to target ABC type transporters in the mammalian liver, and the antagonistic effect observed... -bacterial drugs inhibit growth of malaria parasites by targeting their bacterium-derived endosymbiotic organelles... , the mitochondrion and plastid. Several of these drugs are either in use or being ...

  

Source: McFadden, Geoff - School of Botany, University of Melbourne

 

Collection: Environmental Sciences and Ecology

 
75 Cell, Vol. 93, 951960, June 12, 1998, Copyright 1998 by Cell Press The C. elegans Cell Corpse
 

Summary:  MDR1 disrupt its drug transport activity but not its abilityare loaded with anti-ABC1 antibodies... Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters In the nematode Caenorhabditis elegans... protein has sequence similarity to and are readily distinguishable using ...

  

Source: Horvitz, H. Robert - Department of Biology, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
76 Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic
 

Summary:  83 Chapter 5 Lack of strain-related differences in drug metabolism and efflux transporter... genes and drug efflux transporters were investigated by real- time RT-PCR in the liver, kidney... were observed between the two strains. Also mRNA expression profiles of cyp and drug ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
77 Summary and concluding remarks Thermophilic organisms thrive at relatively high temperatures in geothermally heated regions such
 

Summary:  drugs, vitamins, lipids and so forth. Mutations in genes encoding for ABC transporters can cause... of transport ATPases studied in this thesis is the ATP-binding cassette (ABC) Transporters. ABC transporters... or cystic ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
78 This journal is c The Royal Society of Chemistry 2011 Mol. BioSyst. Cite this: DOI: 10.1039/c0mb00326c
 

Summary:  ,26 To identify nonspecific drug efflux pumps, we examined the effects of a series of ABC transporter deletion... relatively Table 1 The MIC values against ABC transporter deleted strains Strain MIC values for each drug (mg... transporters ...

  

Source: Boone, Charlie - Department of Molecular and Medical Genetics, University of Toronto

 

Collection: Biotechnology

 
79 9, , 15780 : . , .:210 772 3129, Fax: 210 772 3228,
 

Summary:  that are being explored for diverse applications, ranging from drug delivery carriers to polymer electrolytes... of amphiphilic block copolymer (ABC) self-assembly in selective solvents and ABC applications in (a... ) the environmentally benign synthesis of nanoparticles (NP) in a size- and shape-controlled manner. ...

  

Source: Papadopoulos, Evangelos - Department of Mechanical Engineering, National Technical University of Athens

 

Collection: Engineering

 
80 The Elementary Mass Action Rate Constants of P-gp Transport for a Confluent Monolayer of MDCKII-hMDR1 Cells
 

Summary:  ABSTRACT The human multi-drug resistance membrane transporter, P-glycoprotein, or P-gp, has been... decade that some mammalian multi-drug resistance transporters also play an important role... - tive drug concentration to allow quantification of transport from donor ...

  

Source: Mittal, Aditya - School of Biological Sciences, Indian Institute of Technology, Delhi

 

Collection: Biotechnology ; Biology and Medicine


Page:   1  2  3  4  5 
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81 Chapter 3 Enrichment of adenine nucleotidebinding proteins using the ATPbased nucleotide analogues
 

Summary:  of adeninenucleotide binding proteins is described in this chapter. Several overproduced ABC transporters... kinase (3KU2 panel A and C) and the ABC transporter MJ0796 (1L2T panel B and D). The position... transporter is part of the walker A motif present in all ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
82 Research Participants Information Sheet Study Title: Evaluation of the ABC Programme
 

Summary:  targeted initiatives to support those living with drug problems. The ABC programme offers a number... Research Participants Information Sheet Study Title: Evaluation of the ABC Programme Invitation... Paragraph Drug use and abuse is associated with some of the major social and health problems faced

  

Source: Paxton, Anthony T. - Department of Pure and Applied Physics, Queen's University Belfast

 

Collection: Physics ; Materials Science

 
83 Systematic exploration of synergistic drug pairs Murat Cokol1,2,
 

Summary:  Systematic exploration of synergistic drug pairs Murat Cokol1,2, *, Hon Nian Chua1,3 , Murat Tasan1... 5545; E-mail: fritz.roth@utoronto.edu Received 13.7.11; accepted 11.8.11 Drug synergy allows... a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when ...

  

Source: Roth, Frederick - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
84 Molecules 2002, 7, 5162 ISSN 1420-3049
 

Summary:  optimisation is advocated. Keywords: ADME filters, combinatorial library design, drug discovery. The Emergence... to deliver the "first-in-class" drug on the market has forced the pharmaceutical industry to embark... in a costly, yet untested, drug discovery paradigm: Hunting for the new gene, the new target, the new lead

  

Source: Oprea,Tudor I. - Department of Biochemistry and Molecular Biology, University of New Mexico

 

Collection: Biology and Medicine

 
85 Mathematical and Computer Modelling 47 (2008) 560579 www.elsevier.com/locate/mcm
 

Summary:  convective and diffusive transport limitations in delivering anticancer drug into tumours regardless... the nanoparticles and a homogeneous, not drug resistant tumour of one cell type, the fundamental transport... aspect of our model is the presence of blood-borne chemotherapeutic drugs ...

  

Source: Maini, Philip K. - Centre for Mathematical Biology & Mathematical Institute, University of Oxford

 

Collection: Mathematics ; Biology and Medicine

 
86 Advanced Drug Delivery Reviews 48 (2001) 137138 www.elsevier.com/locate/drugdeliv
 

Summary:  with the mathematical treatment of drug triggered transport (swelling) and degradation/ero- transfer through mucus... Advanced Drug Delivery Reviews 48 (2001) 137­138 www.elsevier.com/locate/drugdeliv Preface... Mathematical modeling of controlled drug delivery Mathematical modeling of controlled ...

  

Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin

 

Collection: Biology and Medicine ; Materials Science

 
87 1. Ajouz, B., C. Berrier, A. Garrigues, M. Besnard, and A. Ghazi. 1998. Release of thioredoxin via the mechanosensitive channel MscL during osmotic downshock of Escherichia coli cells. J.Biol.Chem. 273:26670-
 

Summary:  subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis. EMBO J. 19... . 1998. The ABC maltose transporter. Mol.Microbiol. 29:685-694. 37. Ellis, R. J. 2001. Macromolecular... . and D. C. Wiley. 2001. Structure of the ABC ATPase domain of human TAP1, the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
88 Molecular & Biochemical Parasitology 173 (2010) 162164 Contents lists available at ScienceDirect
 

Summary:  ,6], over- expression of drug efflux pumps (Pgp A) [4] and modulation of drug uptake transporters... isolates that demonstrated overex- pression of ABC transporter MRPA, -glutamyl cysteine synthetase... . Role of ABC transporter MRPA, ...

  

Source: Fairlamb, Alan - Division of Biological Chemistry and Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine

 
89 368 VOLUME 86 NUMBER 4 | OCTOBER 2009 | www.nature.com/cpt STATE ART nature publishing group
 

Summary:  are beginning to examine additional drug transporters from the ABC family.14 ACKNOWLEDGMENTS This research... Transporters belonging to the adenosine triphosphate (ATP)- binding cassette (ABC) superfamily maintain... of concentration gradient. The ABC ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
90 DOI: 10.1126/science.1147614 , 1390 (2007);317Science
 

Summary:  of biochemical data and the structures of full ABC transporters determined in recent years, a conserved coupling... mechanism for ABC transporters has recently been proposed that suggests that binding of ATP to the NBDs... ModBC, BtuCD may nevertheless largely follow the common coupling mechanism of ...

  

Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
91 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School
 

Summary:  statute which prohibits transport offederal statute which prohibits transport of unapproved drugs... the Pharmaceutical Industry History, Pricing, Drug Pipeline, Blockbuster Drugs, Legislative Trends, Federal Courts... History, Pricing, Drug Pipeline, Blockbuster ...

  

Source: Schutt, Clarence E.- Departments of Chemistry & Molecular Biology, Princeton University

 

Collection: Chemistry ; Biology and Medicine

 
92 Copyright 2009 by the Genetics Society of America DOI: 10.1534/genetics.109.108068
 

Summary:  that function in detoxification of xenobiotic compounds through drug transport and metabolism have been... organic cation transporters: their functions and interactions with drugs. Trends Pharmacol. Sci. 25: 375... -Cross Analysis Reveals Genes With Drug-Specific and Background-Dependent ...

  

Source: Fay, Justin - Center for Genome Sciences & Department of Genetics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
93 LmrR is a transcriptional repressor of the expression of the Multidrug ABC transporter LmrCD in
 

Summary:  Chapter LmrR is a transcriptional repressor of the expression of the Multidrug ABC transporter Lmr... in Lactococcus lactis 62 SUMMARY LmrCD is an ABC-type multidrug transporter of Lactococcus lactis. LmrR encodes... resistance of L. lactis is due to the expression of the heterodimeric ATP- binding cassette ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
94 Published on Web Date: October 21, 2010 r 2010 American Chemical Society 82 DOI: 10.1021/cn100078a |ACS Chem. Neurosci. (2011), 2, 8289
 

Summary:  of the multidrug resistance-linked ABC drug transporter, ABCG2. Biochemistry 45, 8940­8951. 33. Ambudkar, S. V... density and capacity of P-gp vs BCRP. Keywords: Positron emission tomography, drug transporters, P... transporters belonging to the ATP-bind- ing ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
95 PROTEIN INTERACTIONS AND DISEASE MARICEL KANN
 

Summary:  of protein-protein inter- actions. Kelly et al. study ABC transporter proteins which are involved in sub... understanding, diagnostics, prognostics, drug response and clinical therapy is one of the three fundamental... - strate transport through the membrane. By investigating ...

  

Source: Radivojac, Predrag - School of Informatics, Indiana University

 

Collection: Computer Technologies and Information Sciences

 
96 Structure of the transcriptional regulator LmrR and its mechanism of multi-drug recognition
 

Summary:  structure of a transcription factor regulating the expression of a multi-drug ABC transporter. It is also... R-related transcriptional repressor that regulates the production of LmrCD, a major multidrug ABC transporter in Lactococcus... ,28). The molecular mechanisms of substrate ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
97 Pharmaceutical Chemistry B.S. 1. General description and characteristics of the program.
 

Summary:  emphasizes the chemistry of drug design and development, drug action, drug transport, drug delivery... of biological processes and mechanisms of drug action. Progress in the field now depends on the design... , and computer-aided drug design. In ...

  

Source: Michigan Technological University, School of Forest Resources and Environmental Science, Aspen FACE (Free-Air Carbon Dioxide Enrichment) Experiment

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
98 http://www.jclinpharm.org Pharmacology
 

Summary:  , Cummins CL, Wu CY. Transporter-enzyme interac- tions: implications for predicting drug-drug interactions... from in vitro data. Curr Drug Metab. 2003;4:393-398. 3. Chan LM, Lowes S, Hirst BH. The ABCs of drug... transport in intestine and liver: efflux proteins ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
99 Summary and concluding remarks Summary and concluding remarks
 

Summary:  of cholesterol homeostasis in macrophages by different ABC-transporters, and the consequences for atherosclerotic... their transformation into foam cells. Several ABC- transporters facilitate the efflux of cholesterol from macrophages... to outside of the membrane. Several members - 120 - #12;Chapter 7 of the ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
100 10.1177/0091270004269705ARTICLEKHARASCH ET ALEVALUATION OF CYP3A AND P-GLYCOPROTEIN ACTIVITIES USING ALFENTANIL AND FEXOFENADINEDRUG METABOLISM AND TRANSPORT Evaluation of First-Pass Cytochrome P4503A
 

Summary:  , Hirst BH. The ABCs of drug transport in intes- tine and liver: efflux proteins limiting drug absorption... exhib- its marked interindividual variability, owing to widely DRUG METABOLISM AND TRANSPORT J Clin... /10 mM formic acid (3:7), and transferred to autosampler ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine


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