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Sample search results for: a-769662 activates ampk

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1 Research article TheJournalofClinicalInvestigation http://www.jci.org
 

Summary:  of hepatic gluconeogenesis by AICAR and A-769662 in AMPK- deficient hepatocytes... AICAR stronglyinhibitedglucoseproductioninbothAMPK12-null andcontrolhepatocytes(Figure3A).Incontrast,A-769662had... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
2 AMPK: Lessons from transgenic and knockout animals Viollet Benoit 1 *
 

Summary:  .viollet@inserm.fr> Abstract AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase... to nutritional environmental variations. AMPK system is a regulator of energy' balance that, once activated... or activation of AMPK ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
3 AMPK: Lessons from transgenic and knockout animals Benoit Viollet1,2
 

Summary:  variations. AMPK system is a regulator of energy balance that, once activated by low energy status, switches... activators and agents that deplete intracellular ATP have been supportive of AMPK playing a role... discuss recent findings obtained from animal models with inhibition or ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
4 Acta Physiol (Oxf) . Author manuscript AMP-activated protein kinase in the regulation of hepatic energy
 

Summary:  that A-769662 is a new specific activator of AMPK. Unlike Goransson et al., 2007 other AMPK activators, A... further AMPK activity ( , ). Second, A-769662Cool et ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
5 AMPK in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.
 

Summary:  -769662 is a new specific activator of AMPK. Unlike other AMPK activators, A-769662 directly activates... stimulated further AMPK activity (Cool et al., 2006, Goransson et al., 2007). ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
6 AMPK inhibition in health and disease Benoit Viollet1,2
 

Summary:  in the treatment of obesity. However, the use of a small molecule direct AMPK activator A- 769662 was shown to have... of amassed energy , in order to adapt energy supply to demand. The AMP-activated protein kinase (AMPK... second messenger for reporting cellular ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
7 Crit Rev Biochem Mol Biol . Author manuscript AMPK inhibition in health and disease
 

Summary:  direct AMPK activator A-769662 was shown to have beneficial effects on both hepatic steatosis and insulin... balance. Control of AMPK activity involves allosteric AMP and ATP regulation, auto-inhibitory features... represents an ideal second messenger for reporting ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
8 Pour obtenir le grade de DOCTEUR DE L'UNIVERSIT DE GRENOBLE
 

Summary:  ..........................................................56 3.3.1. Mutation of BCK at Ser6 prevents phosphorylation by activated AMPK 1 and 2....57 3.3.2. Ser... .3.3. Active AMPK interacts transiently with BCK wild-type via its subunit N-terminal domain... ...

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
9 This is an, un-copyedited, author manuscript that has been accepted for publication in the Frontiers in Targeting the AMPK pathway for the treatment of Type 2 diabetes
 

Summary:  activation 10- Role of AMPK in the regulation of -cell function 11- Management of cardiovascular diseases... by AMPK activation 12- Conclusion and medical perspectives 13- Acknowledgments 14- References inserm... .g., imbalance between energy intake and energy expenditure). AMP-activated ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
10 Front Biosci . Author manuscript Targeting the AMPK pathway for the treatment of Type 2 diabetes
 

Summary:  .g., imbalance between energy intake and energy expenditure). AMP-activated protein kinase (AMPK... conditions of disordered energy balance. Recent evidences that pharmacological activation of AMPK improves... ) have recently been reported to activate AMPK. In the ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
11 The University of New Mexico An NSF Integrative Graduate
 

Summary:  generated from cAMP can stimulate AMP-activated kinase (AMPK) and thereby also induce egg maturation in mice... . In control assays of SW- or cAMP-induced maturation, AMPK was initially active in immature eggs... -free seawater or AMPK agonists added to SW kept AMPK ...

  

Source: New Mexico, University of - Center for High Technology Materials

 

Collection: Materials Science

 
12 A Mathematical Model of the Regulation of AMPK Activation
 

Summary:  A Mathematical Model of the Regulation of AMPK Activation Arne T. Bittig1 , David Carling2 & Olaf... 2007. Background: AMPK AMP-activated protein kinase (AMPK): regulation of cell's energy metabolism... -regulating system for - fast response to signal (changes in [AMP]) - high ...

  

Source: Rostock, Universität - Institute for Informatics, Systems Biology and Bioinformatics Group

 

Collection: Biotechnology ; Biology and Medicine

 
13 Behavioral/Systems/Cognitive Metabolic Stress Modulates Motor Patterning via
 

Summary:  concentration within the metathoracic neuropile. We examined the role of the AMP-activated protein kinase (AMPK... rhythm following recovery. AMPK activation using 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR... . Ouabain-induced recurring SD was suppressed by inhibition of AMPK ...

  

Source: Robertson, Meldrum - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
14 Maintenance of red blood cell integrity by AMP-activated protein kinase 1 catalytic subunit
 

Summary:  , Gosselies, Belgium Abstract AMP-activated protein kinase (AMPK) plays a pivotal role in regulating cellular... . Genetic studies in lower eukaryotes suggest that activation of AMPK allows the organism to survive periods... of hemolytic anemia phenotype caused by the absence of AMPK1 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
15 ISSN: 1524-4636 Copyright 2006 American Heart Association. All rights reserved. Print ISSN: 1079-5642. Online
 

Summary:  .-J. Shyy Objective--The regulation of AMP-activated protein kinase (AMPK) is implicated in vascular biology... the regulation of the AMPK­eNOS pathway in vascular endothelial cells (ECs) by shear stress and the activation... rate or pulsatility. The activity of LKB1, the upstream kinase ...

  

Source: Garland Jr., Theodore - Department of Biology, University of California at Riverside

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
16 Activation of AMP kinase 1 subunit induces aortic vasorelaxation in mice Running title: Vasorelaxation associated with AMP kinase 1 subunit
 

Summary:  energy demand. The AMP-dependent protein kinase (AMPK) is a serine/threonine kinase that is activated... with phenylephrine (1µM) and activation of AMPK was induced by addition of increasing concentrations of 5... -/- but not AMPK2-/- mice. Taken together, the results show that ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
17 INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE AMP-activated Protein Kinase and FoxO
 

Summary:  by the AMP-activated protein kinase (AMPK) pathway. The energy-sensing AMPK directly phosphorylates FoxO tran... - scription factors at six regulatory sites. AMPK phosphorylation enhances FoxO tran- scriptional activity... studies, we have focused on the importance of the energy-sensing ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
18 The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor*S
 

Summary:  . The AMP-activated protein kinase (AMPK) plays a critical role in the cellular responses to low energy... by AMPK leads to the activa- tion of FOXO3 transcriptional activity without affecting FOXO3 subcellular... and cancer. The AMP-activated protein kinase (AMPK)3 ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
19 data would suggest that KATP channel-blocking drugs, which have been used for
 

Summary:  of these nutrient-sensing proteins, AMP-activated protein kinase (AMPK), is activated by a wide range of stimuli... of wild-type or active AMPK is sufficient to extend life span in worms (Apfeld et al., 2004; Greer et al... AMPK expression or knock- down of ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
20 Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation
 

Summary:  phosphor- ylation, which activates the enzyme (14, 15). In the periphery, AMPK activation is associated... reciprocal fashion to regulate food intake (15, 17­19). Kahn and collaborators (20) showed that AMPK activity... stimulates levels of phospho-AMPK (Fig. 2A) as ...

  

Source: Kim, Sangwon F. - Laboratory of Neuronal Cell Signaling, University of Pennsylvania

 

Collection: Biology and Medicine


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21 Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK
 

Summary:  TOR) pathway. In peripheral tissue, the energy sensor AMP- activated Protein Kinase (AMPK) negatively regulates... and anti-Type II Diabetes drug, metformin, or AMP mimetic AICAR results in activation of AMPK, repression... , in concert with upstream kinases leads to full activation of ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
22 The regulation of AMPK signaling in a natural state of profound metabolic rate depression
 

Summary:  . 2009 Abstract In response to energy stress (and elevated AMP), the AMP-activated protein kinase (AMPK... ) coordi- nates the restoration of energy homeostasis. We determined that AMPK is activated in a model... regulator of AMPK. Accordingly, *2-fold increases in AMPKa1 protein and ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
23 Characterization of the AMP-activated protein kinase pathway in chickens Monika Proszkowiec-Weglarz a,, Mark P. Richards a
 

Summary:  Abstract In mammals, AMP-activated protein kinase (AMPK) is involved in the regulation of cellular energy... of phosphorylated (active) AMPK in different tissues and in different states of energy balance. Immunocytochemical... analysis of the chicken hypothalamus showed that activated ...

  

Source: Ramachandran, Ramesh - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
24 doi:10.1152/ajpcell.00127.2009 297:750-758, 2009. First published Jul 1, 2009;Am J Physiol Cell Physiol
 

Summary:  unknown. We have previously shown that AMP-activated protein kinase (AMPK) in- creases nitric oxide (NO... of GI neurons to decreased glucose from 2.5 to 0.7 mM or to AMPK activation. Conversely, activation of s... the effect of sGC activation or 8-Br-cGMP, and ...

  

Source: Routh, Vanessa H. - Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
25 Evaluation of the role of AMP-activated protein kinase and its downstream targets in mammalian hibernation
 

Summary:  kinase (AMPK) could play a regulatory role in this reorganization. AMPK activity and the phosphorylation... (Spermophilus tridecemlineatus) comparing euthermic animals with squirrels in deep torpor. AMPK activity... and Storey, 2004). The AMP-activated protein kinase ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
26 Current Biology 17, 16461656, October 9, 2007 2007 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2007.08.047 An AMPK-FOXO Pathway Mediates
 

Summary:  are still poorly characterized. AMP-activated protein kinase (AMPK) is activated by a decrease in energy... of this DR method on lifespan. Expression of an active version of AMPK in worms increases stress resistance... and extends longevity in a FOXO/DAF-16-dependent manner. Lastly, we ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
27 RESEARCH Open Access AMP-activated protein kinase deficiency reduces
 

Summary:  proposed that peroxynitrite activates 5'-AMP-activated kinase (AMPK), which regulates metabolic pathways... and the response to cell stress. AMPK activation as a consequence of ozone exposure has not been previously... , increase lung tissue peroxynitrite production and ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
28 Cryobiology 53 (2006) 297309 www.elsevier.com/locate/ycryo
 

Summary:  ischaemia and tissue dehydration. We investigated whether the AMP-activated protein kinase (AMPK) could play... a regulatory role in the metabolic re-sculpting that occurs during freezing. AMPK activity... sylvatica) subjected to anoxia, dehydra- tion, freezing, and thawing after freezing. ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
29 DB06-0187/V2 AMPK2 DEFICIENCY AFFECTS CARDIAC CARDIOLIPIN
 

Summary:  Diabetes 03/2007; 56(3): 786-94 #12;2 AMP-activated protein kinase (AMPK) plays an important role... ;3 INTRODUCTION AMP-activated protein kinase (AMPK) signaling pathway plays an important role in controlling... -80% of the total AMPK catalytic activity in this tissue ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
30 The CPT1C 59UTR Contains a Repressing Upstream Open Reading Frame That Is Regulated by Cellular Energy
 

Summary:  (AMPK) activity is tightly regulated under physiological conditions and has been shown to play... 6 | Issue 9 | e21486 #12;and c subunits. AMPK activity is enhanced by AMP binding... in cellular energy level, circulating hormones and nutritional cues. The modulation of AMPK ...

  

Source: Bedwell, David M. - Department of Microbiology, University of Alabama at Birmingham

 

Collection: Biology and Medicine

 
31 Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated
 

Summary:  turtles experience anoxic conditions. AMPK activity and the phosphorylation state of ribosomal translation... scripta elegans) subjected to 20 h of anoxic submergence. AMPK activity increased twofold in white muscle... in heart AMPK activity decreased by 40%. ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
32 Biochem. J. (2006) 394, 545555 (Printed in Great Britain) doi:10.1042/BJ20051844 545 The ubiquitin-associated domain of AMPK-related kinases regulates
 

Summary:  -associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation... , phos- phorylates and activates a group of protein kinases that are related to AMPK (AMP-activated... protein kinase). Ten of the 14 AMPK- related ...

  

Source: van Aalten, Daan - Division of Biological Chemistry and Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine

 
33 Outside JEB THE JOURNAL OF EXPERIMENTAL BIOLOGY 206 (23)
 

Summary:  protein kinase (AMPK). Indeed, the activation of AMPK can mediate some of the metabolic effects associated... of activating the AMPK pathway on glycolytic and oxidative metabolic profiles. In order to test these hypotheses... , the authors injected rats for a month with a compound, AICAR, ...

  

Source: Nebraska-Lincoln, University of - School of Biological Sciences, Center for Avian Cognition

 

Collection: Biology and Medicine

 
34 Essential Regulation of Cell Bioenergetics by Constitutive InsP3
 

Summary:  of pyruvate dehydrogenase and activation of AMPK, which activates prosurvival mac- roautophagy. Thus... . Absence of this Ca2+ transfer results in inhibition of pyruvate dehydrogenase and activation of AMPK... for AMPK activity. Notably, KO cells ...

  

Source: Cooper, John - Department of Cell Biology and Physiology, Washington University in St. Louis; Parker, Ian - Department of Neurobiology and Behavior, University of California, Irvine

 

Collection: Biology and Medicine

 
35 ARTICLE IN PRESS Nutrient sensing and metabolic decisions
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 2.2. Downstream effects of AMPK activation... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 0 2.2.4. AMPK activators as anti-diabetes and anti-obesity drugs... and responsive ...

  

Source: Rutter, Jared - Department of Biochemistry, University of Utah

 

Collection: Biology and Medicine

 
36 Cancer Sci | November 2008 | vol. 99 | no. 11 | 21362141 doi: 10.1111/j.1349-7006.2008.00933.x 2008 Japanese Cancer Association
 

Summary:  not significantly different between those two groups. In contrast, metformin activated AMPK in the intestinal polyps... about the effect of metformin-mediated activation of AMPK in intestinal epithelial cells. Recently... K), lipid phosphatase PTEN and AMPK.(14) In particular, ...

  

Source: 

 

Collection: Biotechnology ; Biology and Medicine

 
37 Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1
 

Summary:  ; Protein structure AMP-activated protein kinase (AMPK) is a master met- abolic regulator and an important... the activation of AMPK by its upstream kinases, as well as inhibits the dephospho- rylation/inactivation of AMPK... loop in green. The Thr residue in the ...

  

Source: Tong, Liang - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
38 Cell Metabolism Hypothalamic Fatty Acid Metabolism Mediates
 

Summary:  as the mechanism activated by ghrelin. RESULTS Fasting Induces Phosphorylation of Hypothalamic AMPK and Decreases... , this hypothesis has not been confirmed by data link- ing AMPK stimulation with ghrelin orexigenic activity. ICV... induces activation of AMPK, phos- ...

  

Source: Askari, Amir - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
39 doi:10.1152/ajpcell.00641.2008 296:746-756, 2009. First published Feb 11, 2009;Am J Physiol Cell Physiol
 

Summary:  sensing were mediated by 5 -AMP-activated protein kinase (AMPK). We conclude that during energy... , decreased leptin and glucose activate AMPK in NPY-GI neurons. As a result, NPY-GI neurons become depolarized... energy sensor, 5 -AMP-activated protein kinase (AMPK), ...

  

Source: Routh, Vanessa H. - Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
40 Mammalian Hibernation: Physiology, Cell Signaling, and Gene Controls on Metabolic
 

Summary:  of AMP-activated protein kinase (AMPK ­ see below) activity in the hypothalamus by adipokines and gut... -derived peptides plays a role in food intake. A decrease in hypothalamic AMPK activity is associated with decreased... feeding, whereas AMPK ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine


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41 The Open Obesity Journal, 2010, 2, 43-49 43 1876-8237/10 2010 Bentham Open
 

Summary:  demonstrated the ability of these receptors to ligand dependently activate the 5'-AMP-activated kinase (AMPK... , intracellular ATP concentration is reduced and the AMP level rises. AMP then activates AMPK and triggers... through which AMPK can be regulated is through ...

  

Source: 

 

Collection: Biotechnology ; Biology and Medicine

 
42 The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for
 

Summary:  worms in addi- tion to its well known function in metabolic control. AMP-activated protein kinase (AMPK... such as oxidative stress, hypoxia, ischemia, and heat shock (1). AMPK activates catabolic enzymes and inhibits... phosphorylates and activates AMPK in mammalian ...

  

Source: Gartner, Anton - Wellcome Trust Centre for Gene Expression and Regulation, University of Dundee

 

Collection: Biology and Medicine

 
43 N /__/__/__/__/__/__/__/__/__/__/ submitted to obtain the degree of
 

Summary:  of rapamycin (mTOR), adenosine monophosphate-activated protein kinase (AMPK) and general control non... and GCN2 phosphorylation. Using AICAR (AMPK activator) and rapamycin (mTOR inhibitor), we demonstrated... of rapamycin » (mTOR), « adenosine monophosphate-activated protein kinase » ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
44 Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition
 

Summary:  the enhanced activation of AMP-activated protein kinase (AMPK) and the peroxisome proliferator- activated... suppressors, including AMP-activated protein kinase (AMPK).23 27 mTOR is located at the intersection of major... nutrient deprivation, energy depletion, and ...

  

Source: 

 

Collection: Biotechnology ; Biology and Medicine

 
45 Aging Cell (2009) 8, pp113127 Doi: 10.1111/j.1474-9726.2009.00459.x 2009 The Authors 113
 

Summary:  in Caenorhabditis elegans. We have previously shown that the low-energy sensing AMP-activated protein kinase AMPK... suggested to act as a DR mimetic (Sinclair, 2005). Resveratrol has recently been found to activate AMPK... -dependent, FoxO-independent pathway. Therefore, activation of ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
46 Transworld Research Network 37/661 (2), Fort P.O.
 

Summary:  the phosphorylation and activation of AMP- dependent kinase (AMPK) and other substrates. LKB1 is also involved... ), AMP-activated protein kinase (AMPK) or brain-specific kinases 1 and 2 (BRSK1 and BRSK2 respectively... from skeletal and heart muscles prior to birth (68). AMPK2 ...

  

Source: Marignani, Paola - Department of Biochemistry and Molecular Biology, Dalhousie University

 

Collection: Biology and Medicine

 
47 The development of Kaposi sarcoma, a highly vascular tumour of endothe-
 

Summary:  activates the PI3K­Akt­mTOR pathway and inactivates a negative regulator of mTOR called AMPK... pro-angiogenic cytokines. So, is KSHV-mediated activation of the PI3K­Akt­mTOR pathway important... in endothelial cell tubule formation and angiogenesis? Chemical inhibition of mTOR, or activation of its

  

Source: Damania, Blossom - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
48 200 Cell 142, July 23, 2010 2010 Elsevier Inc. carboxylated osteocalcin increases
 

Summary:  of adeonsine monophosphate- activated protein kinase (AMPK), a sensor of energy insufficiency (Hardie, 2007... , energy lev- els drop, AMPK is activated, and autophagy is engaged to preserve energy and cell sur- vival... production de- clines, and AMPK is activated. ...

  

Source: Parker, Ian - Department of Neurobiology and Behavior, University of California, Irvine

 

Collection: Biology and Medicine

 
49 The Krebs cycle meets the cell cycle: Mitochondria and the G1S transition
 

Summary:  the activation of AMP-activated kinase (AMPK). The activation of AMPK was then shown to augment p53 activity... - dependent activation of a G1­S check- point (5). Activation of AMPK after energetic stress ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
50 Reproductive Toxicology 32 (2011) 8592 Contents lists available at ScienceDirect
 

Summary:  SirT1-independent effects activating the AMP-dependent kinase (AMPK), a key regulator of cellular... and whole-body energy home- ostasis, and neurite outgrowth [11]. AMPK is activated by depletion of cellular... level. 3.2. Resveratrol activates AMPK and MAP kinases ...

  

Source: Mellon, Pamela L. - Department of Reproductive Medicine, University of California at San Diego

 

Collection: Biology and Medicine

 
51 Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
 

Summary:  Gabriele A. Amodeo1 *, Michael J. Rudolph1 * & Liang Tong1 AMP-activated protein kinase (AMPK) is a central... the heterotrimer core of SNF1 in its activated state. Most AMPKs (including SNF1) are heterotrimeric enzymes, con... LETTERS Crystal structure of the heterotrimer core of Saccharomyces cerevisiae ...

  

Source: Tong, Liang - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine

 
52 doi:10.1152/ajpregu.00207.2007 293:592-600, 2007. First published May 30, 2007;Am J Physiol Regulatory Integrative Comp Physiol
 

Summary:  showed that glucose and leptin inhibit NO production via the AMP-activated protein kinase (AMPK) pathway... GI neurons. Hyperglycemia- induced inhibition of AMPK reduces PI3K signaling by activating... was restored in the presence of the AMPK activator, ...

  

Source: Routh, Vanessa H. - Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
53 Resistin-like molecule-inhibits SGLT-1 activity and enhances GLUT2-dependent jejunal glucose transport
 

Summary:  activation of AMPK and PKC kinases and an insertion of GLUT2 transporters in jejunal brush border membranes... intestine. The activation of AMPK has been shown to downregulate SGLT-1-dependent glucose transport but also... is crucial for the AMPK activity. As evoked ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
54 Metformin Suppresses Azoxymethane-Induced Colorectal Aberrant Crypt Foci by Activating
 

Summary:  mellitus. Adenosine monophosphate-activated protein kinase (AMPK) is known to be activated by metformin... TOR pathway through the activation of AMPK. As metformin is already used daily as an antidiabetic drug... , colorectal cancer; AMPK, adenosine mono- ...

  

Source: 

 

Collection: Biotechnology ; Biology and Medicine

 
55 Metabolic reprogramming, caloric restriction and aging
 

Summary:  metabolism by an AMP-activated protein kinase (AMPK), fatty acid trans- porter carnitine palmitoyltransferase... (PGC-1a) [33], a direct target of AMPK phosphorylation that increases its own expression when activated... in an adiponectin- dependent manner. In this case, adiponectin acts through ...

  

Source: Turner, Monica G. - Department of Zoology, University of Wisconsin at Madison

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
56 Skeletal muscle hexokinase: regulation in mammalian hibernation Khalil Abnous Kenneth B. Storey
 

Summary:  of protein phosphatases significantly lowered the HK activity in both situations. AMPK... protein kinases (PKA, PKC, PKG or AMPK) did not change HK activity (Fig. 5b). However, stimulation of AMPK... that stimulated either PP1 or AMPK activities. ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
57 LAUSANNE INTEGRATIVE METABOLISM AND NUTRITION ALLIANCE Tuesday May 10th, 2011
 

Summary:  this hypothesis by activating the AMPkinase/PGC1 pathway in three cytochrome c oxidase defective mouse... overexpression, or treatment with the AMPK agonist AICAR. We then observed remarkable recovery

  

Source: Floreano, Dario - Laboratory of Intelligent Systems, Ecole Polytechnique Fédérale de Lausanne

 

Collection: Computer Technologies and Information Sciences ; Engineering

 
58 Developmental Cell, Vol. 9, 843854, December, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.devcel.2005.11.006 Mitochondrial Regulation of Cell Cycle Progression
 

Summary:  energy stores is computed by AMP- activated protein kinase (AMPK). The heterotrimeric AMPK protein... , resulting in the activation of AMPK (Hardie, 2005). In a recent paper, Jones et al. (2005) showed... that glucose limitation in mouse embryonic fibroblasts can cause phosphoryla- tion ...

  

Source: Banerjee, Utpal - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
59 Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage, Reversed by Increases in pAMPK, Heme
 

Summary:  of AMP-activated protein kinase (AMPK) and pAKT increases the phosphorylation of a number of target... of the activities of pAMPK and peNOS and an increase in vascular repair in diabetic animals. These data ex- tend our... - breviations: AKT, phosphatidylinositol 3-ki- nase; AMPK, ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
60 Structure of the Bateman2 Domain of Yeast Snf4: Dimeric Association and Relevance for
 

Summary:  AMP-activated protein kinase (AMPK) is a cen- tral regulator of energy homeostasis in mam- mals. AMP... is believed to control the activity of AMPK by binding to the g subunit of this het- erotrimeric enzyme... :ATP concentration ratio (signifying energy depletion) leads to the activation ...

  

Source: Tong, Liang - Department of Biological Sciences, Columbia University

 

Collection: Biology and Medicine


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61 ISSN: 1524-4563 Copyright 2009 American Heart Association. All rights reserved. Print ISSN: 0194-911X. Online
 

Summary:  A large body of evidence has shown that activated AMPK and phosphatidylinositol 3-kinase/AKT sig- naling... participates in regulation of cell survival and protects against oxidative stress.18­21 Activation of AMPK... , catabolic processes.19,21 AMPK activation is ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
62 Am J Physiol Heart Circ Physiol. Author manuscript Myocardial ischemic postconditioning against ischemia-reperfusion is
 

Summary:  site is essential14 for AMPK activation ( ) which has been demonstrated to limit ischemic injury during... postischemic reperfusion ( ). Our results34 30 demonstrated that postconditioning activated AMPK by increasing... ). In addition, the phosphorylated AMPK to total ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
63 Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice
 

Summary:  is essential for AMPK activation (34) which has been demonstrated to limit ischemic injury during postischemic... reperfusion (30). Our results demonstrated that postconditioning activated AMPK by increasing its... AMPK to total AMPK ratio was also increased by IPCD ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
64 farmers alone. If this is the case, then subsequent dilution through migration and admixture, after
 

Summary:  of adenosine monophosphate (AMP)­activated protein kinase (AMPK), a conserved regulator of the metabolic... through the activity of adenosine monophosphate (AMP)­activated protein kinase (AMPK) (6, 7). Furthermore... of gene expression patterns in muscle of S6K1-/- mice with those of ...

  

Source: Gems, David - Institute of Healthy Ageing & Department of Genetics, Evolution and Environment, University College London

 

Collection: Environmental Sciences and Ecology

 
65 The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK,
 

Summary:  in pAMPK and pAKT crosstalk (55­57). Further activation of pAMPK and pAKT increases glucose transport... function (56, 61, 62). Furthermore, activated AMPK alone has been suggested as a therapeutic target... The L-4F mimetic peptide prevents insulin resistance through increased levels of ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
66 Creatine kinase regulation by reversible phosphorylation in frog muscle Christopher A. Dieni a
 

Summary:  effect on activity (Singh et al., 2004). Protein kinase A (PKA), protein kinase G (PKG), PKC and AMPK... ) Incubations that promote endogenous protein kinase activities including AMPK and Ca2+ /CaMK. (b) Incubations... on CK activity (Singh et al., 2004). AMPK also ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
67 doi:10.1152/ajpregu.00216.2006 292:1418-1428, 2007. First published Dec 14, 2006;Am J Physiol Regulatory Integrative Comp Physiol
 

Summary:  . The effects of glucose and leptin were mediated by suppression of AMP-activated protein kinase (AMPK... ). The AMPK activator 5-aminoimidazole-4-carboxamide-1- -4- ribofuranoside (AICAR) increased both... ). This antibody is phosphorylated by AMP-activated protein kinase ...

  

Source: Routh, Vanessa H. - Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
68 TORC: A New Twist on Corticotropin-Releasing Hormone Gene Expression
 

Summary:  , 2009. Accepted January 12, 2010. For article see page 1109 Abbreviations: AMPK, AMP-activated protein... different members of the AMP- activated protein kinase (AMPK) fam- ily of ser/thr protein kinases have been... in activation of PKA, which in turn inhibits members of the ...

  

Source: Spencer, Robert L. - Department of Psychology, University of Colorado at Boulder

 

Collection: Biology and Medicine

 
69 Energy metabolism in adult neural stem cell fate Victoria A. Rafalski a,b
 

Summary:  of rapamycin (mTOR) AMP-activated protein kinase (AMPK) Sirtuin Sirt1 Hypoxia-inducible factors (HIFs) A B... O and insulin/IGF-1-mTOR signaling, AMP-activated protein kinase (AMPK), SIRT1, and hypoxia-inducible factors... ribonucleotide; AMPK, AMP-activated protein ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
70 www.sciencemag.org SCIENCE VOL 326 16 OCTOBER 2009 379 PERSPECTIVES
 

Summary:  activity--alters output of the circadian clock. AlthoughAMPK is an attractive candidate for coupling... to glucose concentrations only in wild-type cells, but not in the absence of AMPK. In mouse liver... , the accumulation and nuclear localization of AMPK, as well as the phosphorylation of known ...

  

Source: Fellous, Jean-Marc - Department of Psychology, University of Arizona

 

Collection: Biology and Medicine

 
71 Involvement of PerArntSim (PAS) kinase in the stimulation of preproinsulin and pancreatic
 

Summary:  an analogous role in the activation of PASK to that of Thr-172 in 5 -AMP-activated protein kinase (AMPK... to a decrease in AMPK activity in clonal cells (8, 15, 17) and in islets (18), and forced expression... of activated AMPK suppresses ...

  

Source: Rutter, Jared - Department of Biochemistry, University of Utah

 

Collection: Biology and Medicine

 
72 HO-1 expression increases mesenchymal stem cell-derived osteoblasts but decreases adipocyte lineage
 

Summary:  separate experiments, pb0.05. (B) Effect of siRNA HO-1 on OGP-mediated pAMPK activation. pb0.05 and pb0... and inhibitors of HO activity on MSC differentiation to the osteoblast and adipocyte lineage. HO-1 expression... levels precedes an increase in alkaline phosphatase (AP) activity and an increase in BMP, ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
73 PAS kinase is required for normal cellular energy balance
 

Summary:  to metabolic syndrome development (5, 6). AMP-activated protein kinase (AMPK) and mammalian target of rapamycin... ATP consumption to ATP pro- duction (7). In contrast to AMPK, mTOR is activated by sufficient cellular... (9). Decreased AMPK activity and elevated mTOR ...

  

Source: Rutter, Jared - Department of Biochemistry, University of Utah

 

Collection: Biology and Medicine

 
74 ORIGINAL ARTICLE Overexpression of heme oxygenase-1 increases human osteoblast
 

Summary:  ), antirabbit polyclonal antibodies against pAMPK, AMPK, eNOS, and peroxisome proliferator-activated receptor... the effect of inducers of HO-1 expression and inhibitors of HO activity on MSC differ- entiation... , and BMP-2. Inhibition of HO activity pre- vented the increase in ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
75 doi:10.1182/blood-2009-10-251082 Prepublished online March 18, 2010;
 

Summary:  production within the cell. AMPK is activated when the cellular AMP/adenosine triphosphate (ATP) balance... are sufficiently replen- ished. The glitazone class of drugs is known to activate AMPK,7,8 leading us... to hypothesize that AMPK activation may be of ...

  

Source: Damania, Blossom - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
76 Kaposi's SarcomaAssociated Herpesvirus Confers a Survival Advantage to Endothelial Cells
 

Summary:  , which leads to the inactivation of AMP-activated protein kinase (AMPK) and TSC 2 (17). We have... AMPK. We find that this activation of the PI3K/Akt cell survival pathway in endothelial cells infected... cells induces activation of the PI3K/Akt/mTOR pathway and inactivation of ...

  

Source: Damania, Blossom - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
77 DOI: 10.1126/science.1204592 , 1429 (2011);332Science
 

Summary:  , Bruce E. Kemp The adenosine monophosphate (AMP)­activated protein kinase (AMPK) regulates whole... -body and cellular energy balance in response to energy demand and supply. AMPK is an abg heterotrimer activated... by decreasing concentrations of adenosine triphosphate (ATP) and increasing AMP ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
78 Critical Review The Role of PAS Kinase in Regulating Energy Metabolism
 

Summary:  expres- sion and AMPK and TOR activity were not affected in PASK deficient mice, suggesting PASK may... in controlling cellular metabolic flux and efficiency (3). The AMP-activated protein kinase (AMPK) and the target... are conserved throughout eukarya. AMPK is ...

  

Source: Rutter, Jared - Department of Biochemistry, University of Utah

 

Collection: Biology and Medicine

 
79 *Corresponding author: Bart STAELS, INSERM UMR 1011, Universit Lille Nord de France, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP245, 59019 Lille -France. Tel. +33.3.20.877.388 -Fax
 

Summary:  Kinase-3 (GSK3), AMP-activated Protein Kinase (AMPK)]. inserm-00587038,version1-19Apr2011 #12;5 Protein... ), and the regulatory (1 or 2) and (1, 2 or 3) subunits. AMP-activated protein kinase (AMPK) is a master regulator... as a result, for example, of low glucose, hypoxia, ischemia, or heat shock [38-40]. ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
80 Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
 

Summary:  on its target, AMP-activated protein kinase (AMPK), and showed that the transporter was highly expressed... of metformin on AMP-activated protein kinase in skeletal muscle cells Metformin activates AMPK in the liver... performed an AMPK ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
81 SUPPLEMENTARY INFORMATION 1www.nature.com/nature
 

Summary:  restriction6,7 , activate AMPK, allowing it to directly phosphorylate and activate FOXO3a, without affecting... -5 . It is tempting to speculate that decreased mTORC1 activation due to DR-mediated suppression of PI3K may... its cellular localization8 . Through such a mechanism AMPK may ...

  

Source: Sabatini, David M. - Whitehead Institute for Biomedical Research & Department of Biology, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
82 Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to
 

Summary:  of ERK-1/2, an effect that was further enhanced by leptin. AICAR, the pharmacological activator of AMPK... . Similarly, AICAR, a pharmacological activator of AMPK, induced a strong phosphorylation of ERK-1/ 2 proteins... activator of AMPK. These data argue for the ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
83 The Arabidopsis thaliana SOS2 gene encodes a protein kinase that is required for salt tolerance
 

Summary:  -regulated by salt stress in the root. Auto- phosphorylation assays show that SOS2 is an active protein kinase... . This mutation abolishes SOS2 autophosphorylation, indicating that SOS2 protein kinase activity is required... -type H -ATPases serves as the primary pump that generates a protonmotive force driving the active

  

Source: Zhu, Jian-Kang - Institute for Integrated Genome Biology, University of California at Riverside

 

Collection: Biotechnology

 
84 Myosin VI insert responsible for reverse motion 876 Competition, not cooperation, drives biofilm production
 

Summary:  was associated with increased liver and skeletal-muscle levels of phosphorylated AMP-activated kinase (AMPK... within the biofilm. At the same time, the expansion of these productive cells suffocated less- active... that is normally suppressed by gut microbes. Although Fiaf-knockout mice had high levels of ...

  

Source: Foster, Kevin - Department of Zoology, University of Oxford

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
85 Introduction Mutations in the LKB1 threonine protein kinase gene lead to
 

Summary:  phosphorylates and activates the AMP-activated protein kinase (AMPK) (Hawley et al., 2003; Shaw et al., 2004b... ; Shulman et al., 2000). LKB1 activates AMPK and the AMPK-related kinases by phosphorylating a conserved Thr... , polarity and proliferation by ...

  

Source: van Aalten, Daan - Division of Biological Chemistry and Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine

 
86 Introduction Mutations in the LKB1 threonine protein kinase gene lead to
 

Summary:  phosphorylates and activates the AMP-activated protein kinase (AMPK) (Hawley et al., 2003; Shaw et al., 2004b... ; Shulman et al., 2000). LKB1 activates AMPK and the AMPK-related kinases by phosphorylating a conserved Thr... , polarity and proliferation by ...

  

Source: Komander, David - Laboratory of Molecular Biology, MRC

 

Collection: Biology and Medicine

 
87 Epoxyeicosatrienoic Acid Agonist Rescues the Metabolic Syndrome Phenotype of HO-2-Null Mice
 

Summary:  )-enoic acid; NUDSA, 11-(nonyloxy)undec-8(Z)-enoic acid; WT, wild type; d, deuterium; AMPK, AMP-activated... protein kinase; pAMPK, phosphorylated AMP-activated protein kinase; pAKT, phos- phorylated serine... through the activation of eNOS, via cross- talk between pAKT and ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
88 but had little effect on binding of TBP to the TAFdep promoters of the ACT1 and RPS5
 

Summary:  monophosphate­activated protein kinase (AMPK). Loss-of-function mutations in the homologous gene in yeast (SNF4... ): the catalytic chain (Snf1) and the two regulatory subunits (Sip1, Sip2, and Gal83) and (Snf4). AMPK is activated... by an in- crease in the ratio of AMP to adenosine triphosphate (AMP:ATP). ...

  

Source: 

 

Collection: Biology and Medicine

 
89 Fritz et al. lipid synthesis and cancer Abrogation of de novo lipogenesis by SCD1
 

Summary:  the activation of AMP-activated kinase (AMPK) and GSK3/, the latter on being consistent with a decrease... ). Interestingly, BZ36 activated AMPK more efficiently than the classical AMPK activator AICAR (Figure 4C). We next... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
90 2007LANDESBIOSCIENCE.DONOTDISTRIBUTE. [Cancer Biology & Therapy 6:10, 1-5, EPUB Ahead of Print: http://www.landesbioscience.com/journals/cbt/article/4787; October 2007]; 2007 Landes Bioscience
 

Summary:  phosphorylates and activates AMPK, a regulator of cellular energy, and 11 other AMPK-related kinases in an energy... not shown). Further to this we evaluated the activation of AMPK by LKB1 in complex with STRAD isoforms... neither engaged LKB1-dependent AMPK pathway ...

  

Source: Marignani, Paola - Department of Biochemistry and Molecular Biology, Dalhousie University

 

Collection: Biology and Medicine

 
91 Cell Host & Microbe Human Cytomegalovirus Protein UL38 Inhibits
 

Summary:  activ- ity. Stress activates AMP kinase (AMPK), which phosphorylates TSC2 and activates it. When the TSC... is also activated by the withdrawal of nutrients, because energy deprivation activates AMPK, which... . AMP binds to and allows ...

  

Source: Rout, Michael P. - Laboratory of Cellular and Structural Biology, Rockefeller University

 

Collection: Biology and Medicine

 
92 Cell Host & Microbe Human Cytomegalovirus Protein UL38 Inhibits
 

Summary:  activ- ity. Stress activates AMP kinase (AMPK), which phosphorylates TSC2 and activates it. When the TSC... is also activated by the withdrawal of nutrients, because energy deprivation activates AMPK, which... an increase in the AMP/ATP ratio in ...

  

Source: Chait, Brian T. - Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University

 

Collection: Biology and Medicine

 
93 in the hypothalamic regions were determined. To detect protein expression of a1 and a2 DN-AMPK and g1 CA-AMPK in the
 

Summary:  in the hypothalamic regions were determined. To detect protein expression of a1 and a2 DN-AMPK... and g1 CA-AMPK in the hypothalamus after injection of adenoviruses, we immunoprecipitated AMPK from... , a2, b1, b2 and g1 subunits of AMPK (for CA-AMPK) (gift from D. Carling) or this ...

  

Source: Cluzel, Philippe - Department of Molecular and Cell Biology , Harvard University

 

Collection: Physics ; Biology and Medicine

 
94 in the hypothalamic regions were determined. To detect protein expression of a1 and a2 DN-AMPK and g1 CA-AMPK in the
 

Summary:  in the hypothalamic regions were determined. To detect protein expression of a1 and a2 DN-AMPK... and g1 CA-AMPK in the hypothalamus after injection of adenoviruses, we immunoprecipitated AMPK from... , a2, b1, b2 and g1 subunits of AMPK (for CA-AMPK) (gift from D. Carling) or this ...

  

Source: Emonet, Thierry - Department of Molecular, Cellular and Developmental Biology, Yale University; Shimizu, Tom - AMOLF, Foundation for Fundamental Research on Matter (FOM); Xu, J. M. "Jimmy" - Division of Engineering, Brown University

 

Collection: Biology and Medicine ; Materials Science ; Physics

 
95 COMICR-769; NO. OF PAGES 2 Please cite this article in press as: Curr Opin Microbiol (2010), doi:10.1016/j.mib.2010.04.005
 

Summary:  .sciencedirect.com Current Opinion in Microbiology 2010, 13:1­2 #12;Systems biology of microorganisms is an active research... to metabolomics, an active research field that aims to quantitatively measure the levels of all metabolites... , chemicals and pharmaceuticals is another active research field. Systems biology contributes ...

  

Source: Harvard University, Center for Cancer Systems Biology

 

Collection: Biology and Medicine

 
96 Signaling networks in Eric L. Greer1,2
 

Summary:  ., 2004; Yang et al., 2005). AMPK AMP-activated protein kinase (AMPK) is an energy sensor... that is activated in response to low energy levels. AMPK overexpression extends lifespan in worms by ~13% (Apfeld et... that activate AMPK have been ...

  

Source: Brunet, Anne - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
97 Genomic and Proteomic Approaches in Comparative Biochemistry and Physiology*
 

Summary:  ; Hardie et al. 2003). Once activated, AMPKs phosphorylate numerous targets to produce responses... and activation of the a subunit by upstream pro- tein kinases (particularly AMPK kinase). The b subunits can bind... to glycogen, and therefore, one aspect of AMPK control is that high ...

  

Source: Storey, Kenneth B. - Departments of Biology & Chemistry, Carleton University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
98 doi:10.1152/ajpendo.90932.2008 296:1101-1109, 2009. First published Feb 17, 2009;Am J Physiol Endocrinol Metab
 

Summary:  M) but not by the mitogen-activated kinase (MAPK) inhibitor PD-98059 (PD; 50 M). Finally, neither the AMPK inhibitor... compound C nor the AMPK activator AICAR altered the activity of VMH GE neurons. These data suggest... with insulin in the presence and absence of PD-98059. ...

  

Source: Routh, Vanessa H. - Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey

 

Collection: Biology and Medicine

 
99 Convergent energy and stress Elena Baena-Gonzalez and Jen Sheen
 

Summary:  ) SNF1 and mammalian AMPK (AMP-activated protein kinase), all members of a highly conserved eukaryotic... ]. In mammals, AMPK is activated by hypoxia, ischemia, heat shock and exercise, which increase the AMP/ATP ratio... and cell types [35,39]. However, full characterization of the gene networks regulated by ...

  

Source: Sheen, Jen - Department of Genetics, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
100 Stress and mTORture signaling JH Reiling and DM Sabatini
 

Summary:  -phosphorylating kinase PERK. Low cellular energy level activates AMPK, which inhibits growth by stimulating TSC2 function... (DKO) cells). Cells with elevated Akt/PKB activity showed lowered AMP- activated protein kinase (AMPK... ;stimulating effect on TSC. Conversely, in the PKB1/ PKB2 ...

  

Source: Sabatini, David M. - Whitehead Institute for Biomedical Research & Department of Biology, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine


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