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Sample search results for: a1 proteases evidence

Page:   2  3  4  5 
 
1 Increased Heterologous Protein Production in Aspergillus niger Fermentation through Extracellular Proteases Inhibition by
 

Summary:  derivative of N402 (18), and N402 is a cspA1 derivative of strain ATCC 9029. The GFP gene is fused... Proteases Inhibition by Pelleted Growth Jianfeng Xu, Liping Wang, Darin Ridgway, Tingyue Gu,* and Murray Moo... protease secretion on morphology was inves- tigated by employing the recombinant Aspergillus ...

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
2 The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis
 

Summary:  The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis Eric P. Beersa... proteases (family A1) and the plant matrixin, metalloproteases (family M10A). In this report, 54 subtilisin... -like, 30 papain-like and 59 pepsin-like ...

  

Source: Jones, Alan M. - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
3 Journal of Clinical Immunology, Vol. 18, No. 3, 1998 Special Article
 

Summary:  the inter-a-trypsin inhibitor (123, 124) and a1-macroglobulin (125) families of protease inhibitors... , these inhibitors include a1-antichymotrypsin inhibitor, a1-proteinase inhibitor, secretory leukocyte proteinase... mast cell tryptase and a ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
4 Identification of Structural Mechanisms of HIV-1 Protease Specificity Using Computational Peptide
 

Summary:  Hydrophobic Aromatic b-Branched Charged Polar P3 À0.25 À0.27 +0.69 -- +0.25 +0.36 P2 +0.41 +0.79 <<0.0a +1... Structure Article Identification of Structural Mechanisms of HIV-1 Protease Specificity Using... .str.2009.10.008 SUMMARY Drug-resistant mutations (DRMs) in HIV-1 protease are a major challenge

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Chemistry ; Biology and Medicine

 
5 2011NatureAmerica,Inc.Allrightsreserved. nature structural & molecular biology advance online publication
 

Summary:  .6 and 23.2%, respectively. The final model includes residues 1-55 and 60-124 in monomer A, 1-5, 12... publication b r i e F com mu n i cat i on s Crystal structure of XMRV protease differs from the structures... and protease) provides the most direct path to inactivation of the virus. It has already been ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
6 Breakthrough Technologies Activity Profiling of Papain-Like Cysteine Proteases
 

Summary:  serine, C1A cysteine and A1 aspartic protease families in Arabidopsis. Phytochemistry 65: 43­58 Beers EP... Breakthrough Technologies Activity Profiling of Papain-Like Cysteine Proteases in Plants1 Renier A... . However, activity of many proteins, such as transcription factors, kinases, and ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
7 2003 NaturePublishing Group Proteases perform essential functions in all living
 

Summary:  and 9A1 have also generated two copies of genes that encode the single- copy human metalloproteases ADAM... © 2003 NaturePublishing Group Proteases perform essential functions in all living organisms... . As well as mediating nonspecific pro- tein hydrolysis, proteases also act as processing enzymes

  

Source: Overall, Christopher M. - Department of Oral Biological and Medical Sciences, University of British Columbia

 

Collection: Biology and Medicine

 
8 A Protease Activity Displaying Some Thrombin-like Characteristics in
 

Summary:  , Jones AM, Dickerman A. 2004. The S8 serine, C1A cysteine, and A1 aspartic protease families... of evidence suggests that proteases play both regulatory and effector roles in the pro- grammed cell death... A Protease Activity Displaying Some Thrombin-like ...

  

Source: Jones, Alan M. - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
9 A Phytophthora infestans Cystatin-Like Protein Targets a Novel Tomato Papain-Like Apoplastic Protease1[W][OA]
 

Summary:  C1A-1 to C1A-8. To in- vestigate the relationship between PIP1 and other Cys proteases of plants, we... sequences. The sequences that have been assigned to eight tentative groups (C1A-1­C1A-8; Beers et al., 2004... Protease1[W][OA] Miaoying Tian3 , Joe Win2 , Jing ...

  

Source: van der Knaap, Esther - Department of Horticulture and Crop Science, Ohio State University

 

Collection: Biology and Medicine

 
10 Binding and Cleavage of E. coli HUb by the E. coli Lon Protease Jiahn-Haur Liao,6
 

Summary:  G13 and K18 is a loop that links the a1- and a2-helices. In the HUa monomer, the tertiary fold... are part of the preferred cleavage sites, are indicated. The a1-helix and the a3-helix are shown in red... with each other to generate a V-shape between the a1-helix and ...

  

Source: Chiou, Arthur - Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang-Ming University

 

Collection: Engineering ; Physics

 
11 10.1110/ps.035436.108Access the most recent version at doi: 2008 17: 2023-2037; originally published online Sep 29, 2008;Protein Sci.
 

Summary:  Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6... nucleoporin 98 1ko6 Ser864 His862 Clan SQ Family S58 Ochrobactrum anthropi aminopeptidase DmpA 1b65 Ser250... /His/Asp triad configuration Unconventional serine proteases: ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
12 DOI: 10.1002/cbic.201000442 Mechanisms of Macromolecular Protease Inhibitors
 

Summary:  . The serpins a1-anti- trypsin and antithrombin III,[48] purified from human plasma, are used as replacement... DOI: 10.1002/cbic.201000442 Mechanisms of Macromolecular Protease Inhibitors Christopher J. Farady... progression, to name but a few. Because proteases trigger an irreversible event--the cleavage of ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
13 Protein Expression and Purification 24, 6170 (2002) doi:10.1006/prep.2001.1545, available online at http://www.idealibrary.com on
 

Summary:  A, gene encoding tmRNA in E. coli; LB, Luria­Bertani; DIG, digoxigenin; EOP, equivalent to a1 To whom... Codons, Limits the Accumulation of Recombinant Tobacco Etch Virus Protease in Escherichia coli BL21(DE3... protease enteropeptidase (enterokinase), or thrombin. However, from tobacco etch virus (TEV ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
14 Isatin Compounds as Noncovalent SARS Coronavirus 3C-like Protease Inhibitors
 

Summary:  Ki (experimental) pKi (theoretical)a 1e H I -b 2a CH3 I - 2b CH3CH2CH2 I 25% at 100 µM 2c n-C4H9 I 66 ( 5 µM 6... Isatin Compounds as Noncovalent SARS Coronavirus 3C-like Protease Inhibitors Lu Zhou, Ying Liu... against SARS CoV 3C-like protease. Substitutions at the N-1 and C-5 positions were examined to ...

  

Source: Luhua, Lai - Institute of Physical Chemistry, Peking University

 

Collection: Chemistry ; Biotechnology

 
15 10.1110/ps.052069306Access the most recent version at doi: 2006 15: 1815-1828Protein Sci.
 

Summary:  , Michael R. proteases gleaned from investigations of isolated domains Slicing a protease: Structural... .proteinscience.orgDownloaded from #12;REVIEW Slicing a protease: Structural features of the ATP-dependent Lon proteases gleaned from... , USA Abstract ATP-dependent Lon proteases are ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
16 Biol. Chem., Vol. 385, pp. 525535, June 2004 Copyright by Walter de Gruyter Berlin New York 2004/401100
 

Summary:  is a key factor in wound healing processes. The Ecp protease inactivates a1-protease inhibitor, which seems... and inhibition by a2-macroglobulin The purified protease was incubated with a1PI at an enzyme:inhibitor molar... . This enzyme, with ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
17 NATURE BIOTECHNOLOGY VOL 18 AUGUST 2000 http://biotech.nature.com 847 Interactions between proteins play a critical role in cell function and
 

Summary:  protease. A1 through E8 are protease-coated surfaces to which 40 lysates were applied. Binding was detected... chemotherapeutic agents7. HIV-1 protease is critical to viral maturation and infectivity8,9, and is a primary... target in AIDS chemotherapy10­12. To treat AIDS, attempts have ...

  

Source: Park, Sang-Hyun - School of Biological Sciences, Seoul National University; Raines, Ronald T. - Departments of Biochemistry & Chemistry, University of Wisconsin at Madison

 

Collection: Biology and Medicine ; Chemistry

 
18 letters to nature NATURE |VOL 407 |19 OCTOBER 2000 |www.nature.com 923
 

Summary:  , the archetypal member of the family, a1-antitrypsin7,8 . There have been many unsuccessful attempts over the past... containing an excess of a1-antitrypsin over trypsin, and set up crystallization trials at 4 8C. Crystals were... of a1-antitrypsin in the complex is ...

  

Source: Read, Randy J. - Department of Haematology, University of Cambridge

 

Collection: Biology and Medicine

 
19 Our view of the proteolytic universe has expanded con-siderably in recent years.PROTEASES were initially charac-
 

Summary:  Our view of the proteolytic universe has expanded con- siderably in recent years.PROTEASES were... . Proteases, through their ability to catalyse irreversible hydrolytic reactions,regu- late the fate... cell surfaces; activation or inactivation of proteases and other enzymes,cytokines,hormones or growth

  

Source: Overall, Christopher M. - Department of Oral Biological and Medical Sciences, University of British Columbia

 

Collection: Biology and Medicine

 
20 Product Contents ProTEV Protease
 

Summary:  M DTT V6051 1,000 units V605A V602A (1ml) P117B (250µl) V6052 10,000 units V605B V602B (8ml) P117C (1... Product Contents ProTEV Protease: Supplied With: Cat.# Size ProTEV Protease ProTEV Buffer, 20X 100m... .25ml) Description: ProTEV Protease is an engineered form of TEV ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine


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21 http://genomebiology.com/2002/3/4/reviews/3006.1 commentreviewsreportsdepositedresearchinteractionsinformationrefereedresearch
 

Summary:  , shown as stereo pairs. In the single-chain aspartic protease (b), the corresponding loops are labeled A1... of four struc- tural elements: a hairpin (containing loop A1), a wide loop (B1, containing the catalytic... elements, named A2, B2, C2, and D2 in Figure 3. The length of loops ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
22 Protein Expression and PuriWcation 38 (2004) 108115 www.elsevier.com/locate/yprep
 

Summary:  . It is becoming increas- ingly evident that certain viral proteases have more stringent sequence speci... -speciWc processing of fusion proteins by tobacco vein mottling virus protease in vivo and in vitro Sreedevi... , it is almost always desirable to remove them from the target protein. The proteases that ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
23 An overview of enzymatic reagents for the removal of affinity tags David S. Waugh
 

Summary:  the designed site. Over the last decade or so, it has become increasingly evident that certain viral proteases... are further subdivided into type A1 and type A2 isoforms in ro- dents and humans [121]. Carboxypeptidase A1... - types ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
24 [M189]. Mirabilysin MEROPS name: Mirabilysin[M189]P001
 

Summary:  to as an IgA protease because of its activity on both serum and secretory forms of IgA1 (immunoglobulin A1... mirabilysin. Both human serum IgA1 and human IgG were digested by the recombinant metal- loprotease... . Recombinant mirabilysin degrades ...

  

Source: Belas, M. Robert - Center of Marine Biotechnology, University of Maryland Biotechnology Institute

 

Collection: Biology and Medicine

 
25 MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/00/$04.00 0
 

Summary:  study provides evidence that the targeted cleavage of eIF4GI and -II by the poliovirus 2A protease re... . Knowlton. 1999. Enteroviral protease 2A cleaves dystro- phin: evidence of cytoskeletal disruption... ) Sixtyfold magnification of field 4 from panel A. 1, visible ...

  

Source: Kahana, Chaim - Department of Molecular Genetics, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
26 Chemistry & Biology Peptide Length and Leaving-Group Sterics Influence
 

Summary:  a = 79.9 A° b = 80.2 A° c = 40.5 A° b = 95.8 Resolution (last shell) 54.6­1.19 A° (1.25­1.19 A° ) Unique... Phosphonate Protease Inhibitors Christopher M. Brown,1,5 Manisha Ray,1,5 Aura A. Eroy-Reveles,2 Pascal Egea,3... an analysis of parameters influencing potency of peptide phosphonate ABPs for trypsin- fold S1A ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
27 This article was published in an Elsevier journal. The attached copy is furnished to the author for non-commercial research and
 

Summary:  of the protease is revealed, which is most pronounced at S4. The structural evidence for protease extended... evidence for extended substrate specificity for a herpesvirus protease and induced fit for substrate... of the herpes simplex virus type 1 protease: ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
28 A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease
 

Summary:  , Amedeo Caflisch c , Xun-Cheng Su d , Kiyoshi Ozawa d , Gottfried Otting d , Subhash G. Vasudevan a,1... of dengue virus protease Christophe Bodenreider a , David Beer a , Thomas H. Keller a , Sebastian Sonntag... Promiscuous inhibitors Dengue virus protease a b s t r a c t In drug discovery, the occurrence ...

  

Source: Caflisch, Amedeo - Department of Biochemistry, Universität Zürich

 

Collection: Biology and Medicine

 
29 The 0.83 A Resolution Crystal Structure of a-Lytic Protease Reveals the Detailed Structure of the Active
 

Summary:  A. Data collection Resolution range (A° ) 1.7­0.78 1-1.12 Detector distance (mm) 99 200 MAR plate... The 0.83 A° Resolution Crystal Structure of a-Lytic Protease Reveals the Detailed Structure... Francisco, CA 94143-2240 USA The crystal structure of the extracellular bacterial serine protease a

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
30 Analysis of Methods for Predicting Protein Fold and Remote Homologue Recognition
 

Summary:  ). Upon selection, the method generates 1D-PSSM or 1D-profile using PSI- Blast (A0,A1,A2...). Next... -ray structure has been determined (Rypniewski, et. al, 1993). Trypsin or serine proteases are ubiquitous... , oligopeptidase and omega-peptidase activity. Serine proteases of the chymotrypsin family share a ...

  

Source: Bejerano, Gill - Departments of Computer Science & Developmental Biology, Stanford University

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
31 Structural and biochemical studies of retroviral proteases Alexander Wlodawer *, Alla Gustchina
 

Summary:  : a hairpin (containing loops A1 and A2), a wide loop (B1, containing the catalytic aspartic acid, and B2... , and is replaced by a loop in HIV (both types 1 and 2) and SIV PRs. Also, the length of loops A1 and A2 is di... Review Structural and biochemical studies of retroviral proteases ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
32 A Model of Tumour Angiogenesis and
 

Summary:  e = k7 k-7 ) and hence [CA] = [C] - [CAF] 1 + e [A] . 1 In vivo, there may be additional... respond to a VEGF stimulus by producing protease, which degrades the basement membrane and eventually... to secrete protease and thus degrading the ECM. The protease is viewed as a chemoat- ...

  

Source: Plank, Mike - Department of Mathematics and Statistics, University of Canterbury

 

Collection: Mathematics

 
33 Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched multispecificity protease substrate
 

Summary:  to evidences for the presence of other serine protease activities. Our assay did not detect serine... Stage-specific profiling of Plasmodium falciparum proteases using an internally quenched... multispecificity protease substrate Priyaranjan Pattanaik,a Bimba Jain,a Gudihal Ravindra,b Hosahudya N. Gopi

  

Source: Balaram , P. - Molecular Biophysics Unit, Indian Institute of Science, Bangalore

 

Collection: Biology and Medicine

 
34 A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
 

Summary:  to 1.5 mm), and enzyme (1.5 nm for wild-type RNase A; 1 and 3 lm for the 1C and 2C unactivated zymogens... A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus R. J. Johnson1... cleavage, by cleavage by another protease, or by a con- formational change invoked by the local environment

  

Source: Raines, Ronald T. - Departments of Biochemistry & Chemistry, University of Wisconsin at Madison

 

Collection: Chemistry ; Biology and Medicine

 
35 Communication between the active sites and dimer interface of a herpesvirus protease revealed by a
 

Summary:  proteases as therapeu- tic targets. Indirect evidence has associated dimerization with activity... Communication between the active sites and dimer interface of a herpesvirus protease revealed... of the active site and the dimer interface of wild-type protease in solution. Positional scanning synthetic

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
36 Inhibition of tobacco etch virus protease activity by detergents Arun K. Mohanty, Chad R. Simmons, and Michael C. Wiener*
 

Summary:  of a soluble fusion protein, a1 platelet ac- tivating factor acetylhydrolase (PAFAHa1). Removal... of a polyhistidine affinity tag from the recombinant soluble protein a1 platelet activating factor acetylhydrolase... . Materials and methods Materials The plasmid pHis-PAFAHa1 encoding ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
37 Biochemical Engineering Journal 8 (2001) 187193 Enhanced heterologous protein production in Aspergillus niger through
 

Summary:  402 [17] and N402 is a cspA1 derivative of strain ATCC 9029 [4]. The medium for A. niger cultures... in Aspergillus niger through pH control of extracellular protease activity Dara O'Donnella, Liping Wanga... 2000; accepted 15 February 2001 Abstract The extracellular protease activity of Aspergillus niger AB4

  

Source: Gu, Tingyue - Department of Chemical and Biomolecular Engineering, Ohio University

 

Collection: Biotechnology ; Chemistry

 
38 Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a Lysine Recruited to the Nonconserved Amino-Terminal Domain in the S49 Protease
 

Summary:  , Simon Fraser UniVersity, Burnaby, British Columbia V5A 1S6, Canada, The Skaggs Institute for Chemical... , ompF627(T2 R ), glpA24, fadL701(T2 R ), relA1, glpR8(glpc ), glpR7 (glpn ), glpD26, pit-10, spoT1... Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
39 Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a Lysine Recruited to the Nonconserved Amino-Terminal Domain in the S49 Protease
 

Summary:  , Simon Fraser UniVersity, Burnaby, British Columbia V5A 1S6, Canada, The Skaggs Institute for Chemical... , ompF627(T2 R ), glpA24, fadL701(T2 R ), relA1, glpR8(glpc ), glpR7 (glpn ), glpD26, pit-10, spoT1... Escherichia coli Signal Peptide Peptidase A Is a Serine-Lysine Protease with a ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
40 One Functional Switch Mediates Reversible and Irreversible Inactivation of a Herpesvirus Protease
 

Summary:  ) Separate functional domains of the herpes simplex virus type 1 protease: evidence for cleavage inside... One Functional Switch Mediates Reversible and Irreversible Inactivation of a Herpesvirus Protease... ABSTRACT: Distinct mechanisms have evolved to regulate the function of proteolytic enzymes. Viral ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine


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41 I06 Biochemistry 1991, 30, 106-1 11 Wallace, C. J. A. (1987) J. Biol. Chem. 262, 16767-16770.
 

Summary:  by an anion-exchange column (Figure 4A1), while the HIV2 protease binds tightly and elutes with 1 M Na... Verlag, Basel. Inhibition of HIV Protease Activity by Heterodimer Formation? Lilia M. BabC, Sergio... , 1990 ABSTRACT: The dimeric nature of the HIV protease has been exploited to ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
42 The Cortical Granule Serine Protease CGSP1 of the Sea Urchin, Strongylocentrotus purpuratus,
 

Summary:  and active forms of the protease, is detected in cortical granules by immunoblot analysis. Our evidence... protease species. Here we present evidence that a single gene product encodes the serine protease activity... evidence that it is the major, if not the only, ...

  

Source: Wessel, Gary M. - Department of Molecular Biology, Cell Biology and Biochemistry, Brown University

 

Collection: Biology and Medicine

 
43 The role of I;`0 regions in protein folding David Baker, Andrew K Shiau and David A Agard
 

Summary:  University of California, San Francisco, USA In vivo, many proteases are synthesized as larger precursors... . During the maturation process, the catalytically active protease domain is released from the larger... -terminal pro regions have been shown to play a fundamental role in the folding of the associated protease

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
44 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 11002-11007, October 1996
 

Summary:  CO 0 0 a.1-- b C I ITl TTTt- l- - llFlTF 0.0 0.06 0.25 0.0 0.1 0.2 0.4 0.1 1 10 100 1000 Granzyme B... 17 and poly(ADP-ribose) polymerase is cleaved indicating that this protease although activated... -dependent cell death pathway in some cell types and requires a CPP32-like Ac-DEVD-CHO inhibitable protease ...

  

Source: 

 

Collection: Biology and Medicine

 
45 Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease*
 

Summary:  Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease* Received... protease from tobacco etch virus (TEV) is fre- quently used to remove affinity tags from recombinant... selectivity. The crystal structures of two TEV protease mutants, inactive C151A and autolysis-resistant S219D

  

Source: Waugh, David S.- Macromolecular Crystallography Laboratory, National Cancer Institute; Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Biology and Medicine ; Chemistry

 
46 r XXXX American Chemical Society A dx.doi.org/10.1021/ja109377p |J. Am. Chem. Soc. XXXX, XXX, 000000 COMMUNICATION
 

Summary:  / 0256324 A1, November 17, 2005. (14) Kaneshiro, T. L.; Wang, X.; Lu, Z.-R. Mol. Pharmaceutics 2007, 4, 759... ­000 COMMUNICATION pubs.acs.org/JACS HIV Protease-Mediated Activation of Sterically Capped Proteasome Inhibitors... a cytotoxic, small- molecule proteasome inhibitor upon cleavage by HIV-1 protease. ...

  

Source: Crews, Craig M. - Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Chemistry ; Biology and Medicine

 
47 Molecular Cell 23, 2535, July 7, 2006 2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.05.019 A Branched Pathway Governing the Activation
 

Summary:  protease (His-A1,3,4 in Figure 3B). To test whether these mutants blocked cleavage by IVB in the context... ., 2000) are shown. (B) Purified His-A and cleavage site 1 mutant (S155R), His-A1 ; and cleavage sites 1... , 3, and 4 mutant (S155R, S117R, and A106R), His- ...

  

Source: Rudner, David - Department of Microbiology and Molecular Genetics, Harvard University

 

Collection: Biology and Medicine

 
48 Coming Soon! SigmaFASTTM Protease Inhibitor Tablet for General Use (Cat. No. S8820)
 

Summary:  M Aprotinin, 80 µM Bestatin, 4 mM E-64, 1.4 mM Leupeptin, 2 mM Pepstain A, 1.5 mM AEBSF Bestatin E-64... Coming Soon! SigmaFASTTM Protease Inhibitor Tablet for General Use (Cat. No. S8820) Sample Type... Serine, Cysteine, Aspartic Proteases & Amidopeptidases Serine, Cysteine, Aspartic and Metalloproteases

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
49 Developmental Cell 10, 4555, January, 2006 2006 Elsevier Inc. DOI 10.1016/j.devcel.2005.11.013 A Spatzle-Processing Enzyme Required for Toll
 

Summary:  , we purified it from silkworm hemolymph (Figures 1A­1C). BAEEase was purified in a zymogen form... of innate immunity from insects to humans. Although in Drosophila the Easter protease processes the pro- Spa... ¨tzle protein to generate the Toll ligand during de- velopment, the identification of the ...

  

Source: Lemaitre, Bruno - Centre de Génétique Moléculaire, CNRS

 

Collection: Biology and Medicine

 
50 Regular paper Limited proteolysis of E. coli ATP-dependent protease Lon a unified
 

Summary:  -w.t. or S679A (1­784) 87.4 ND ~ 1000 (?) ~ 50­100 ND ­ ­ (n) ­ Number of subunits; RQ ­ relative quantity... Regular paper Limited proteolysis of E. coli ATP-dependent protease Lon ­ a unified view... ATP-dependent Lon protease from Es- cherichia coli. Four regions sensitive to proteolytic digestion

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
51 Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila*
 

Summary:  proteases, MP1 and MP2. A, the null mutation spn27A1 for the serpin Spn27A results in constitutive... -type strain unless otherwise indicated. The spzrm7 (2), relE20 (18), and spn27A1 (16) mutations, as well... . The Bloomington Stock Cen- ter was the source of all other stocks. In our ...

  

Source: Lemaitre, Bruno - Centre de Génétique Moléculaire, CNRS

 

Collection: Biology and Medicine

 
52 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1065310656, October 1996
 

Summary:  determines the Na -induced allosteric regulation of catalytic activity in serine proteases (allostery blood... for review April 15, 1996) ABSTRACT Residue 225 in serine proteases is typically Pro or Tyr and specifies... an important and unanticipated functional aspect of this class of enzymes. Proteases with Y225, like thrombin

  

Source: Di Cera, Enrico - Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

 

Collection: Biology and Medicine

 
53 The Plant Cell, Vol. 10, 12171228, July 1998, www.plantcell.org 1998 American Society of Plant Physiologists A Cytoplasmic Male SterilityAssociated Mitochondrial
 

Summary:  [C] and 9.1 kb [J]). Both RFLPs mapped to linkage group A, 1.4 centimorgans (LOD 17.7) away from... evidence to support a model of post-translational regulation of ORF239 expression based on the following ob... demonstrated accumulation of ORF239 only when a protease inhibitor was included. Proteolytic ...

  

Source: Mackenzie, Sally A. - Plant Science Initiative & School of Biological Sciences, University of Nebraska-Lincoln

 

Collection: Biology and Medicine

 
54 Biochem. J. (2011) 435, 116 (Printed in Great Britain) doi:10.1042/BJ20100965 1 REVIEW ARTICLE
 

Summary:  Proteases as therapeutics Charles S. CRAIK*1 , Michael J. PAGE* and Edwin L. MADISON *Department... Biosciences, 260 Littlefield Avenue, South San Francisco, CA 94080, U.S.A. Proteases are an expanding class... of drugs that hold great promise. The U.S. FDA (Food and Drug Administration) has approved 12 protease

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
55 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1105411061, September 1999
 

Summary:  biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify... a membrane- type serine protease in epithelial cancer and normal tissue TOSHIHIKO TAKEUCHI*, MARC A. SHUMAN... of Medicine, University of California, San Francisco, CA 94143 ABSTRACT Serine proteases of the ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
56 Chloroplast and Mitochondrial Proteases in Arabidopsis. A Proposed Nomenclature1
 

Summary:  ) Immunochemical studies on the Clp-protease in chloroplasts: evidence for the forma- tion of a ClpC/P complex. Bot... Chloroplast and Mitochondrial Proteases in Arabidopsis. A Proposed Nomenclature1 Zach Adam*, Iwona... (A.K.C). The identity and scope of chloroplast and mitochondrial proteases in higher ...

  

Source: Wollman, Francis-André - nstitut de Biologie Physico-Chimique & Université Pierre-et-Marie-Curie, Paris 6

 

Collection: Biology and Medicine ; Renewable Energy

 
57 Biochemistry 1991, 30, 2263-2272 2263 Steitz, T. A,, & Shulman, R. G. (1982) Annu. Rev. Biophys.
 

Summary:  Structures of a-Lytic Protease Complexes with Irreversibly Bound Phosphonate Esters+?$ Roger Bone,sJ Nicole S... of the complexes with a-lytic protease of both phosphorus stereoisomers of N-[(2S)-2-[ [[(1R)-l - [ N [(tert... an understanding for the structural basis of serine protease catalysis, the structures of many serine ...

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
58 DISEASES OF AQUATIC ORGANISMS Dis Aquat Org
 

Summary:  is the location of initial ciliate invasion. In several other parasitic infections, proteases released... , some parasite proteases degrade host extracellular matrix proteins, thus facilitating spread... pathogens secrete proteases during in vitro culture, suggesting that protease release could be im- portant

  

Source: Graves, John E. - Virginia Institute of Marine Science, College of William and Mary

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
59 HIV-1 Protease Catalytic Efficiency Effects Caused by Random Single Amino Acid Substitutions
 

Summary:  HIV-1 Protease Catalytic Efficiency Effects Caused by Random Single Amino Acid Substitutions... immunodeficiency virus type 1 (HIV-1) protease was chosen as a model protein to quantify protein's tolerability... the vulnerability of HIV-1 protease to single random mutations. When a second random mutagenesis library

  

Source: Dean, Matthew D. - Department of Ecology and Evolutionary Biology, University of Arizona; Nachman, Michael - Department of Ecology and Evolutionary Biology, University of Arizona

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
60 Research Letters AIDS 2005, 19:529533
 

Summary:  of individual HIV-1 protease inhibitors against cytomegalovirus. This computational study provides evidence... Research Letters AIDS 2005, 19:529­533 Virtual screening of HIV-1 protease inhibitors against human... cytomegalovirus protease using docking and molecular dynamics Ekachai Jenwitheesuk and Ram ...

  

Source: Samudrala, Ram - Department of Microbiology, University of Washington at Seattle

 

Collection: Biotechnology ; Biology and Medicine


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61 Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite
 

Summary:  of these two proteins. Several differences were of note (Fig. 7). First, while the procathepsin L a1 helix... from binding due to a steric clash between the occluding loop and the prodomain residues connecting a1... to this observation. In the model, the interaction of the helices equivalent to cathepsin L ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
62 Critical Review Serine Proteases
 

Summary:  (7), emerges as a key embodiment of the serine protease fold especially evident in the trypsins... Critical Review Serine Proteases Enrico Di Cera Department of Biochemistry and Molecular Biophysics... proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most pre- dominant genetic

  

Source: Di Cera, Enrico - Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine

 

Collection: Biology and Medicine

 
63 Nature Macmillan Publishers Ltd 1998 intact protein antigens6
 

Summary:  proteases must work in concert to deliver a carefully orchestrated series of cuts... in antigen presentation7,8 , indicating that other proteases are involved in both removing Ii and converting... the antigen into peptides. One might assume, perhaps naively, that many lysosomal proteases are functionally

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
64 Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates
 

Summary:  additional parasite activities. In particular, there is strong evidence for cysteine proteases participating... Falstatin, a Cysteine Protease Inhibitor of Plasmodium falciparum, Facilitates Erythrocyte Invasion... , Stanford, California, United States of America Erythrocytic malaria parasites utilize ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
65 10.1101/gad.1440606Access the most recent version at doi: 2006 20: 1911-1922; originally published online Jun 30, 2006;Genes & Dev.
 

Summary:  and resistance to antimicrobial peptides in Evidence for a novel protease governing regulated intramembrane data... February 13, 2008 - Published bywww.genesdev.orgDownloaded from #12;Evidence for a novel protease governing... W thrC prsWH175A 1.48 0.06 prsW thrC ...

  

Source: Losick, Richard M. - Department of Molecular and Cellular Biology, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
66 Proc. Natl. Acad. Sci. USA Vol. 96, pp. 1101511022, September 1999
 

Summary:  protease inhibitors as chemotherapy: Lessons from a parasite target PAUL M. SELZER*, SABINE PINGEL, IVY... , Germany ABSTRACT Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion... , selectivity, and safety of cysteine protease inhibitors in cell culture or in vivo. We now report

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
67 Inference of Structure, Function and Motion of an Ancestral Protein by Lee Pedersen, Jotun Hein and Mark Sansom.
 

Summary:  . It is homologous to several other proteins, all serine proteases. It appears to have either lost enzymatic activity... as acomplex with protein Z-dependent protease inhibitor (ZPI) (Tabatai et al. 2001). The most important known... , and is therefore not a zymogen of a serine protease. Based on its homology to the other ...

  

Source: Goldschmidt, Christina - Department of Statistics, University of Warwick

 

Collection: Mathematics

 
68 The Structure of Chagasin in Complex with a Cysteine Protease Clarifies the Binding
 

Summary:  Structure Article The Structure of Chagasin in Complex with a Cysteine Protease Clarifies... - teases. Cysteine proteases are a large family of enzymes found throughout the plant and animal kingdoms... . Disturbance of the equilibrium be- tween cysteine proteases and natural inhibitors is a key event

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
69 DOI: 10.1002/cbic.200900244 Activity-Based Probes for Monitoring Postproline Protease
 

Summary:  by using a fluorescence scanner. Scheme 1. Reagents and conditions: a) 1 h at 858C; b) Boc-Pro-OH, N... DOI: 10.1002/cbic.200900244 Activity-Based Probes for Monitoring Postproline Protease Activity... affects its interaction with other proteins, which prevents their degradation by most common proteases

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
70 Author's personal copy Journal of Theoretical Biology 253 (2008) 2435
 

Summary:  in terms of four states, namely healthy (T), infected stage 1 (A1), where the cell is infected and able... whether a cell should go into the actively infected (A1) state with a probability Pinf or the latently... reveals that the coefficients of DTÃ n form an arithmetic series in the form of an ¼ ...

  

Source: Kuang, Yang - Department of Mathematics and Statistics, Arizona State University

 

Collection: Mathematics

 
71 10.1110/ps.036715.108Access the most recent version at doi: 2008 17: 1998-2007; originally published online Aug 12, 2008;Protein Sci.
 

Summary:  no evidence of degradation due to the presence of contaminating Escherichia coli proteases (see Supplemental... to plasminogen activator inhibitors (a2-macro- globulin and a1-antitrypsin), as occurs in MS and in animal models... . Michael Evans, Julie Trim, Maria Aparecida Juliano, Isobel A. ...

  

Source: Blaber, Michael - Department of Biomedical Sciences, Florida State University

 

Collection: Biology and Medicine

 
72 and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org The Author 2007. Published by Oxford University Press on behalf of the Society for Molecular Biology
 

Summary:  Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster... marakat@gmail.com Keywords: reproduction, accessory gland proteins, mating, serine proteases Running head... population genetic survey from five female reproductive tract expressed serine proteases that show increased

  

Source: Begun, David - Section of Evolution and Ecology, University of California, Davis

 

Collection: Environmental Sciences and Ecology

 
73 Biochemistry 1995, 34, 11521-1 1527 11521 Trypsin Specificity Increased through Substrate-Assisted Catalysis?
 

Summary:  of LODC by trypsin H57A. Cleavage reaction mixtures contained trypsin H57A (1 .7 yM) and LODC (3.2 p... in theP2 or P1' position. This preference creates new protease specificities for sequences HRI, RJH, HKI... proteases and thereby develop various unique specificities for peptide and protein hydrolysis. ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
74 Inhibition of a Viral Enzyme by a Small Molecule Dimer Disruptor Tina Shahian1, Gregory M. Lee2, Ana Lazic2, Leggy A. Arnold3, Priya Velusamy3, Christina
 

Summary:  protease of human Kaposi's sarcoma-associated herpesvirus (KSHV) were identified by screening an -helical... titration using selectively labeled 13C-Met samples revealed that monomeric protease is enriched... . These results validate the interface of herpesvirus proteases and other similar oligomeric interactions

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
75 The International Journal of Biochemistry & Cell Biology 41 (2009) 16011612 Contents lists available at ScienceDirect
 

Summary:  .53 1348.3 ND ND ND Boc-Asp-Pro-Arg-AMC 0.69 0.35 1976.3 0.28a 1.16a 244.35 D-Val-Leu-Arg-AMC 0.14a 4.53a... .elsevier.com/locate/biocel A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features... 20 February 2009 Keywords: Cathepsin B Fasciola hepatica Liver fluke Cysteine ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
76 , 112 155 : (02)2826-7000#5710, : (02)2820-1093
 

Summary:  -001-PAE, NSC 95-2627-B-010-004, NSC 95-2627-B-001-001) Lon protease ATP Lon protease HU protein Lon... protease HU protein Lon proteaseHU protein 1. Lon protease ATP [1] E.coli HU protein HU HU... homologous subunits DNA [2] Lon protease HU ...

  

Source: Chiou, Arthur - Institute of Biophotonics, School of Biomedical Science and Engineering, National Yang-Ming University

 

Collection: Engineering ; Physics

 
77 Cell Host & Microbe Structural Basis for Activation and Inhibition
 

Summary:  , repre- senting CPAFn and CPAFc (Figure 2A). The N terminus of CPAFn forms a three-helix bundle (a1, a3... CPAF molecules, and their interaction is predominantly mediated by the packing of a1and b17 together... by lacta- cystin, but also provide structural evidence that lactacystin can ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
78 Functional Consequences of the Kaposi's Sarcoma-Associated Herpesvirus Protease Structure: Regulation of Activity and Dimerization by Conserved Structural
 

Summary:  of ActiVity. Herpesviral proteases dimerize via helices R5 and R1 in a nonconserved fashion, as is evident... Functional Consequences of the Kaposi's Sarcoma-Associated Herpesvirus Protease Structure... of Kaposi's sarcoma-associated herpesvirus protease (KSHV Pr), at 2.2 Å resolution, reveals the active

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco; Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
79 Crystal Structure of a Novel Viral Protease with a Serine/Lysine Catalytic Dyad Mechanism
 

Summary:  , Canada V5A 1S6 2 Unite´ de Virologie et Immunologie Mole´culaires Institut National de la Recherche... are essential for activity (Figure 4). Ser692 resides just before helix a1 and Lys729 resides within helix a2... Crystal Structure of a Novel Viral Protease with a Serine/Lysine ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
80 THE EXTRACELLULAR PROTEOME OF BACILLUS SUBTILIS UNDER SECRETION STRESS CONDITIONS
 

Summary:  C- mrr)114::IS10 R(mcr-73::miniTn10)2 R(zgb-210::Tn10)1 (TetS) endA1 [dcm] IMPACT-CNTM System Chong et al... ) Noone et al., 2001 DN200 trpC2; htrA1[N289H S290M] htrB::Km amyE::PhtrA-bgaB; Cm r , Em r , Km r Noone... proteome of an htrA1 htrB double mutant strain ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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81 CLIP-CHIPTM, a Dedicated Microarray of All Proteases and Inhibitors
 

Summary:  CLIP-CHIPTM, a Dedicated Microarray of All Proteases and Inhibitors The CLIP-CHIP is a customized... 70mer oligonucleotide based microarray containing all human proteases (558) and inhibitors (157... ) Advantages: ·CLIP-CHIP enables transcription studies of proteases and protease inhibitors to be carried out

  

Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia

 

Collection: Engineering

 
82 Biophysics of Malarial Parasite Exit from Infected Erythrocytes
 

Summary:  Institutes of Health (Grants R01 HL094270-01A1 and 1-R01-GM076689-01). YKP and YS were also supported... the host cells through parasitic and host derived proteases of cysteine and serine families. We used... previously reported broad-spectrum inhibitors (E64d, EGTA-AM and chymostatin) to inhibit these ...

  

Source: Dao, Ming - Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT); Suresh, Subra - Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT)

 

Collection: Materials Science

 
83 Gene,69 (1988)231-244 Molecular analysis of the gene encoding a-lytic protease: evidence for a preproenzyme
 

Summary:  -lytic protease: evidence for a preproenzyme (Recombinant DNA; extracellular serine protease; Lysobacter... that a-lytic protease is synthesized as a larger precursor strengthens the evidence that pre- * Evidence... RI fragment containing the structural gene for ...

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biotechnology ; Biology and Medicine

 
84 The expanding diversity of serine hydrolases Istvan Botos1
 

Summary:  IgA1-specific serine peptidase S06.003 1WXR [16 ] NS3 protease S7 Flavivirin S07.001 2FOM,2FP7 [17... protease GlpG (2ic8). The core of the GlpG molecule is formed by six transmembrane helices (a1­a6... -linked homodimer [10] and cleaves factor IX. Each monomer has ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
85 Biochem. J. (2002) 368, 273281 (Printed in Great Britain) 273 Critical role of amino acid 23 in mediating activity and specificity of
 

Summary:  primers (A1, 5h-CCAATATGCTATTAGAAAAAATC- 3h and B, 5h-GTGCTTATATTTTCCCTATCGG-3h). The same primers were... in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria... proteases of Plasmodium falciparum, known as falcipains, have been identified as ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
86 A mathematical model of intercellular signaling during epithelial wound healing Filippo Posta
 

Summary:  centered at cA - ¯s: lim n p(¯l, ¯s) = H(¯l + ¯s - cA) = 1 ¯l cA - ¯s 0 ¯l < cA - ¯s . (27) In this limit... listed in Table I. Mathematical Model The experimental results from [8, 9] provide evidence of spatio... of the MAPK cas- cade "black box", a protease that is the intracellular precursor ...

  

Source: Levine, Alex J. - Department of Chemistry and Biochemistry, University of California at Los Angeles

 

Collection: Materials Science

 
87 doi:10.1152/ajpheart.00777.2005 290:1278-1288, 2006. First published Oct 14, 2005;Am J Physiol Heart Circ Physiol
 

Summary:  .physiology.orgDownloadedfrom #12;Innovative Methodology Specific serine proteases selectively damage KCNH2 (hERG1) potassium... C. Makielski, Blake D. Anson, and Craig T. January. Specific serine proteases selectively damage... . 1) Specific ex- ogenous serine proteases (protease XIV, XXIV, or proteinase K) ...

  

Source: Kamp, Tim - Molecular and Cellular Pharmacology Training Program & Department of Physiology, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
88 Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Protease-activated receptor signaling: new roles and
 

Summary:  . Protease-activated receptor signaling: new roles and regulatory mechanisms Stephen F. Traynelisa and Jo... Ann Trejob Purpose of review Protease-activated receptors are G-protein-coupled receptors that transmit... cellular responses to coagulant proteases in a variety of cell types in the vasculature and other tissues

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
89 Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti
 

Summary:  Expression profiling and comparative analyses of seven midgut serine proteases from the yellow... such as endoproteolytic serine proteases, carboxypepti- dases and aminopeptidases (Noriega et al., 2002; Noriega and Wells... , 1999; Sanders et al., 2003). Of particular interest are the midgut serine proteases that function

  

Source: Miesfeld, Roger L. - Department of Chemistry and Biochemistry, University of Arizona

 

Collection: Biology and Medicine ; Chemistry

 
90 High-resolution structure of Ascaris trypsin inhibitor in solution: direct evidence for a pH-induced
 

Summary:  (A) among the reactive sites (residues P2-P2') of different serine protease inhibitors.a 1CSE 25SI 20... restraints were classified into four ranges, 1.8-2.7A, 1.8-3.3 A, 1.8-5.0A and 1.8-6.0A, cor- responding... classified into one of four ...

  

Source: Clore, G. Marius - Laboratory of Chemical Physics. National Institutes of Health

 

Collection: Biology and Medicine

 
91 Molecular Cell, Vol. 14, 207219, April 23, 2004, Copyright 2004 by Cell Press A Cathepsin L Isoform that Is Devoid of a Signal
 

Summary:  A 1A1 toxic T cells and natural killer cells, and cathepsin LCanada has been found to catalyze... ). Evidence for participation of a calpain-like cysteine protease in cell cycle progression through late G1... Department of Oncology notion that cysteine ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
92 Crystal Structures of Bacillus subtilis Lon Protease Ramona E. Duman and Jan Lwe
 

Summary:  relevant as long as Lon proteases exist as dodecameric species, for which there is no evidence, as yet... Crystal Structures of Bacillus subtilis Lon Protease Ramona E. Duman and Jan Löwe MRC Laboratory... June 2010; accepted 15 June 2010 Lon ATP-dependent proteases are key components of the protein quality

  

Source: structure and motility & Molecular Machines.

 

Collection: Biology and Medicine

 
93 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS On the orientation of the catalytic
 

Summary:  groups are evident in aspartic proteases involved in dis- tinct biological processes in different... proteases Ran Friedman* and Amedeo Caflisch* Department of Biochemistry, University of Zu... ¨rich, Winterthurerstrasse 190, CH-8057 Zu¨rich, Switzerland INTRODUCTION Aspartic proteases (EC 3.4.23) are a ...

  

Source: Caflisch, Amedeo - Department of Biochemistry, Universität Zürich

 

Collection: Biology and Medicine

 
94 Subscriber access provided by -Access paid by the | UCSF Library Nano Letters is published by the American Chemical Society. 1155 Sixteenth
 

Summary:  -Free Technique for Measuring Protease Activity and Inhibition using a Microfluidic Cantilever Array Digvijay A... this article #12;Quantitative and Label-Free Technique for Measuring Protease Activity and Inhibition using... of a model protease immobilized on its surface. Trypsin was covalently bound to the gold surface

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
95 Biochem. J. (2004) 378, 529538 (Printed in Great Britain) 529 Identification and biochemical characterization of vivapains, cysteine
 

Summary:  -first-order equation y = A[1 - exp(- kobst) + B], where y is the fluorescence at time t, A the amplitude of the reac... characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax Byoung-Kuk NA*1... of California, San Francisco, CA 94143, U.S.A. Cysteine proteases play ...

  

Source: Craik, Charles S. - Departments of Pharmaceutical Chemistry, Cellular and Molecular Pharmacology & Biochemistry and Biophysics,University of California at San Francisco

 

Collection: Biology and Medicine

 
96 Nature Macmillan Publishers Ltd 1998 freshwater stingrays does not occur along
 

Summary:  a protease that hydrolyses -factor4,5 . Mutants defi- cient in this `barrier activity' (bar1 mutants6... ,7 ) are highly sensitive to phero- mones7 , so the protease was thought to be involved in the recovery of yeast... mutants also mate less efficiently with -cells in a mass mating mixture1 . A role for the protease

  

Source: Barkai, Naama - Departments of Molecular Genetics & Physics of Complex Systems, Weizmann Institute of Science

 

Collection: Biotechnology

 
97 VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane
 

Summary:  primers were prepared as displayed on the PrimerBank Web site6 (40), as follows: cystatin B (6681071a1... ), cystatin C (31981822a1), cathepsin B (6681079a2), cathepsin L (6753558a3), cathepsin H (7106279a3... ), and cathepsin D (18043133a1). PCR primers for ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
98 Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1537415381, December 1998
 

Summary:  Bluescript-mouse cyclin A1, A2). HeLa Cell Extracts. To prepare extracts from S-phase cells, HeLa cells were grown to 50... cyclin A1, which lacks this sequence, was not (data not shown). It is most likely that the production... site (cycA 1­70), were incubated with ...

  

Source: Ruderman, Joan - Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
99 [CANCER RESEARCH 61, 18051809, March 1, 2001] Advances in Brief
 

Summary:  for 4 h, we were unable to detect any histological evidence of protease-mediated tissue damage in either... of mouse tissues for evidence of human Fig. 2. Effect of protease pretreatment on Ad-HSV-tk/GCV treatment... -bearing animals to assess metastatic tumor spread after protease ...

  

Source: Israel, Mark A.- Department of Genetics, Dartmouth College

 

Collection: Biology and Medicine

 
100 pubs.acs.org/BiochemistryPublished on Web 05/12/2009r 2009 American Chemical Society Biochemistry 2009, 48, 57535759 5753
 

Summary:  University, South Science Building, 8888, University Drive, Burnaby, British Columbia, Canada V5A 1S6... 2009, 48, 5753­5759 5753 DOI: 10.1021/bi900461e Profiling the Substrate Specificity of Viral Protease... specificity of a protease is useful in determining its physiological substrates, developing robust ...

  

Source: Paetzel, Mark - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine


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