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Sample search results for: a2 receptors measurement

Page:   2  3  4  5 
 
1 In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to
 

Summary:  activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... and 4 the yeast system is exploited to study inverse agonism of the human adenosine A2B receptor... . At first, constitutively active ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
2 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... are ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
3 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 ago... - nists) and depression (galanin receptor antagonists). The A2A=D2, ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
4 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  ; PKA, protein kinase A; PKC, protein kinase C; PLA2, phospholipase A2; PLC, phospholipase C; PLD... JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165­205, 2004 Dopamine Receptor... The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
5 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of receptors... , termed P2 receptors, specific for nucleoside tri- and diphosphates of purines/pyrimidines. We emphasize

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
6 Copyright C Blackwell Munksgaard 2002 Traffic 2002; 3: 866877
 

Summary:  and F251A) or inactivate the receptor (like N296A) [(2,3) and references 873Traffic 2002; 3: 866... , Strnad J, Pausch MH, Hadcock JR. Pharmacological char- acterization of the rat A2a adenosine receptor... A) that seen with the WT receptor in ...

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
7 AMPA receptor desensitization mutation results in severe developmental phenotypes and early
 

Summary:  in the GluA2 (GluR2) receptor subunit (GluA2L483Y ). This mutation was homozygous lethal. However, mice... receptor subunits GluA1 and GluA2 was decreased, whereas NMDA receptor protein expression was ...

  

Source: Contractor, Anis - Department of Physiology, Northwestern University

 

Collection: Biology and Medicine

 
8 Ligand Stabilization of the 2 Adrenergic Receptor: Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy
 

Summary:  of native and denatured 2 receptor. Far- UV CD spectra of affinity-purified 2 receptor (trace a), 2 receptor... -Tris buffer (trace a), 2 receptor treated with 10 mM DTT for 1 h at room temperature (trace b), and 2 ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
9 Enhancement of the surface expression of G protein-coupled receptors
 

Summary:  -opioid [47] and prostaglandin EP3 receptors [48], RACK1, which enhances trafficking of thromboxane A2... receptors [49], Usp4, which increases plasma membrane expression of adenosine A2A receptors [50], ATBP50... . (2008) RACK1 regulates the cell ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
10 Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors
 

Summary:  -1-induced release of thromboxane A2 from the guinea pig lung and nitric oxide from the rabbit kidney... Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation... : interactions with ETA receptors Armin Just, Andrea J. M. Olson, and William J. Arendshorst Department of Cell

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
11 Diffusion-Dependent Mechanisms of Receptor Engagement and Viral Entry Melissa M. Gibbons,
 

Summary:  in units of a, the radius of the virus spike-cell membrane contact area, and time in units of a2 /p... a , tj ) tp a2 , cj(rj, tj) ) a2 c(r, t) Dj ) D p , qj ) qa2 p , ¯in ) ina2 p , µ¯n ) µna2 p (11) - j)1 N... ) Lieto, A. M.; Cush, R. C.; Thompson, N. L. ...

  

Source: D'Orsogna, Maria Rita - Department of Mathematics, California State University, Northridge

 

Collection: Mathematics

 
12 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  h of receptor stimulation. Our data show that the time course of A2b receptor signaling measured... July 15, 2004; doi:10.1152/ ajpgi.00164.2004.--Adenosine, acting through the A2b receptor, in- duces... in the recruitment of ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
13 1. MadinDarby canine kidney (MDCK) cells, a well-differentiated renal epithelial cell line derived from distal
 

Summary:  in response to many different types of activators of phospholipase (PL)A2, including receptor... was measured using a luciferin/luciferase method.8 RESULTS Which receptors mediate responses of MDCK cells... )-D1 cells. cPLA2, cytosolic phospholipase ...

  

Source: Ostrom, Rennolds - Department of Pharmacology, University of Tennessee Health Science Center

 

Collection: Biology and Medicine

 
14 Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
 

Summary:  , as discussed below, ifenprodil not only affects NR1/NR2B receptors but also triheteromeric NR1/2A/2B receptors... (5):1331­1333 Neyton and Paoletti · Commentary #12;receptors are present in the cortex and hippocampus and NR1/2A/2C... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
15 Interneuron Diversity series Diversity of inhibitory
 

Summary:  -positive interneurons innervate somatic GABAA receptors with a large a1:a2 subunit ratio [35]. This clear segregation... with a1, a2 and a5 TRENDS in Neurosciences (a) 50 pA 200 pA 200 ms / 20 s 100 ms 14 pA (25%) 43 pA (75... distribution patterns. Most ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
16 Current Pharmaceutical Design, 2004, 10, 000-000 1 1381-6128/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  by chemokine receptors has been often used for measurement of their signaling. However, now it appears... rapid release of arachidonic acid in monocytes by activation of phospholipase A2 in a calcium dependent... and PTX-sensitive manner [28]. Activation of phospholipase ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
17 Purine and pyrimidine receptors G. Burnstock
 

Summary:  by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
18 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , complementary DNAs (cDNAs) encoding two different P1 receptor subtypes (A1 and A2) were isolated [20], and... , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking*
 

Summary:  constructs were kindly provided by Ken Minneman (Emory University School of Medicine). 2A-, 2B-, and 2C... receptor-mediated currents were measured from oocytes perfused with "ND96/Ca2 " (96 mM NaCl, 2 mM KCl, 1 m... M KCl. GABAA receptor currents were measured by ...

  

Source: Teissére, Jeremy Alden - Biology Department, Muhlenberg College

 

Collection: Biology and Medicine

 
20 Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking*
 

Summary:  by Ken Minneman (Emory University School of Medicine). 2A-, 2B-, and 2C-adrenergic receptor constructs... after cRNA injection. GABAA receptor-mediated currents were measured from oocytes perfused with "ND96/Ca... electrodes filled with 300 mM KCl. GABAA receptor ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine


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21 ELSEVIER Immunopharmacology33 (1996) 9-15 Immunophannacology
 

Summary:  produce pathophysiologic quantities of mediators such as TxA 2, independent of BK receptor mechanisms... receptor-mediated activationof phospholipaseA2 in 3T3 fi- broblasts. Proc. Natl. Acad. Sci. USA 1988... . Bradykinin (BK) represents such a versatile ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
22 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... to A1 and A2 types were identified in human foetal astrocytes [68]. In these cells, the A1 receptors... inhibited, whereas ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 nature neuroscience volume 1 no 7 november 1998 563 Nervous system signaling depends on the spatially and tempo-
 

Summary:  almost completely colocalized with punctate staining of the GABAA receptor 2 (Fig. 5a), 2 (Fig. 5c) or 1... and regulated distribution of ion channels and neurotransmitter receptors on the neuronal surface seems... of the spinal cord, clustering and postsy- naptic localization of glycine ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
24 doi:10.1152/ajpgi.00147.2006 291:605-610, 2006. First published May 4, 2006;Am J Physiol Gastrointest Liver Physiol
 

Summary:  the pattern of G protein activation by each receptor. In the present study, we measured G protein activa- tion... isoforms of Gi. Silencing of S1P2 receptors abolished S1P-stimulated PLC- activity (measured at 60 s... of S1P2 receptors abolished S1P-stimulated Rho kinase activity ...

  

Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University

 

Collection: Biology and Medicine

 
25 Transmembrane signalling and the aspartate receptor William G Scott1 and Barry LStoddard 2*
 

Summary:  by calculating the total buried surface area in the coiled coil model (-1800 A2 ), the number of side chain... Transmembrane signalling and the aspartate receptor William G Scott1 and Barry LStoddard 2* 1 MRC... Center, 1124 Columbia Street, Seattle, Washington 98104, USA Background: The aspartate receptor

  

Source: Scott, William - Department of Chemistry and Biochemistry, University of California at Santa Cruz

 

Collection: Chemistry

 
26 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors... 1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... on sensory ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 Antisense Inhibition of 5-Hydroxytryptamine2a Receptor Induces an Antidepressant-Like Effect in Mice
 

Summary:  - doxical that mianserin, a 5-HT2A/2C receptor antagonist with an antidepressant effect also elicits... level of 5-HT that may down-regulate the receptor. In contrast, mianserin, a 5-HT2A/2C receptor... with ritanserin, a ...

  

Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh

 

Collection: Biology and Medicine

 
28 Associate editor: A.L. Morrow Regulation of GABAA receptor trafficking, channel activity,
 

Summary:  -deficient mice (Gu¨n- ther et al., 1995). Clustering of a1 and a2 subunit-containing receptor subtypes is reduced... ;rescues clustering of a1 and a2 subunit-containing receptors in the cerebellum and hippocampus... - containing receptors mediate ...

  

Source: Luscher, Bernhard - Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
29 The serotonergic system The Serotonergic System
 

Summary:  . Phospholipase A2 (PLA2) In the early literature, it was found that 5-HT stimulates the activity PLA2... (Jolas et al, 1995). Measurement of the density of 5-HT1A receptors in frontal cortex of suicide victims... modulation of the limbic system 5. Serotonin receptor subtypes 6. Signal ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 Function and structure in glycine receptors and some of their relatives
 

Summary:  must be to measure separately the initial binding of the agonist to the shut receptor... receptor has high affinity for ACh: dissociation of ACh from it occurs at a slow, but measurable, rate [31... rates [25]. The opening rate b2 is also somewhat increased, and the shutting rate ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
31 Architectural and Structural Optimization of the Protective Polymer Layer for Enhanced Targeting
 

Summary:  ) with the density ) (8a)-2 (where a is a cell size of the lattice). We note that the chosen density is about 16... density ( ) (8a)-2), the polymer layer is in so-called brush regime19-21 with a characteristic parabolic... surface and measured the probability Pn to have n functional ...

  

Source: Dormidontova, Elena E. - Department of Macromolecular Science and Engineering, Case Western Reserve University

 

Collection: Engineering ; Materials Science

 
32 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... of skeletal muscle, changes in receptor expression in smooth-muscle phenotypes, maturation of testicular... of blood vessels in hypertensive rats, the appearance of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
33 THEJOURNALOF BIOLOG~CAL CHEMISTRY c ) 1991by The American Society for Biochemistry and MolecularBiology, Inc.
 

Summary:  -conotoxin receptor solubilized from brain membranes whereas specific antibodies against the al, a2,and y subunits did... Abs, two anti-a2, and two anti-y subunit poly- clonal antibodies did not react with the receptor. Fig. 1... - search Bldg., Iowa City, IA 52242. ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
34 Diinosine pentaphosphate: an antagonist which discriminates between recombinant P2X3 and P2X2/3 receptors and between two
 

Summary:  pentaphosphate (Ip5I) is a very potent antagonist at recombinant P2X1 receptors (pA2, 8.2) and is quite active... at P2X3 receptors with a pA2 of 6.3 (King et al., 1999). In this study, we have investigated... /3 receptors and between two P2X ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
35 Characterization of Interactions between Death Receptor 5 and its Ligand TRAIL
 

Summary:  103 Chapter 5 Characterization of Interactions between Death Receptor 5 and its Ligand TRAIL #12... was the result of binding to membrane bound receptors, of which two different types exist[8]. As was the case... for TNF, the receptors were found to be members of a larger family, the TNF-Receptor (TNFR) ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
36 Bulletin of Mathematical Biology (2008) 70: 15251569 DOI 10.1007/s11538-008-9321-6
 

Summary:  of the system was defined as A(t) = a1R(t) + a2X(t) + a3Y(t) + a4D(t), (1) #12;1534 Tindall et al. Fig. 6... , the intracellular phosphorylation cascade, membrane receptor clus- tering, and spatial modeling of intracellular... gradient along their own length, bacteria use a system of membrane receptors and ...

  

Source: Maini, Philip K. - Centre for Mathematical Biology & Mathematical Institute, University of Oxford

 

Collection: Mathematics ; Biology and Medicine

 
37 Pharmacological characterization of serotonin receptor subtypes modulating primary aerent input to deep dorsal horn neurons in
 

Summary:  used were; NAN-190 or WAY-100635, 5-HT1A receptor antagonists; ketanserin, a 5-HT2A/2C receptor... , application of the 5-HT2A/2C receptor antagonist ketanserin alone did not modify synaptic responses... be explained in relation to the relatively ...

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
38 Neuregulin1 Downregulates Postsynaptic GABAA Receptors at the Hippocampal Inhibitory Synapse
 

Summary:  protein kinase II (CaMKII), GAD, and NR2A/2B/2C were 23, 24, 24, 21, 26, 28, and 24, respectively. The PCR... of GABAA 1/ 2, 2, 2 subunits, NR2A/2B/2C subunits, and GAD65/67 was described previously (Sakaguchi et al... Neuregulin1 Downregulates Postsynaptic GABAA Receptors at the ...

  

Source: Corfas, Gabriel - F.M. Kirby Neurobiology Center, Children's Hospital Harvard Medical School

 

Collection: Biology and Medicine

 
39 Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  activate phospholipases A2, C and D, MEP/MAP kinase, Rho-dependent kinase and tyrosine kinase, as well... Science Publishers Ltd. Introduction: P2 Receptors Geoffrey Burnstock* Autonomic Neuroscience Institute... channel P2X and G protein-coupled P2Y receptor subtypes is described. This is followed by a ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
40 Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
 

Summary:  . Similarly, NR1/2A/2C receptors are inhibited by zinc with high potency but low efficacy. Therefore... triheteromeric NR1/2A/2AH128SN614K receptors. When 200 nM Zn was applied under these conditions, 15.7 ± 1... AH128SN614KT690I cDNA, a pure triheteromeric ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics


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41 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic... receptors, the P2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
42 Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
 

Summary:  was prevented by inhibitors of fatty acid formation and phospholipase A2 (Lombardi et al., 1994, 1996). Al... Review Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors Jayne Cartmell... .S.A. Abstract: The G protein-coupled metabotropic gluta- mate (mGlu) receptors are differentially ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
43 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... . Blockade of A2A (P1) receptors antagonises parkinsonian tremor in the rat tacrine model by actions... on specific ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
44 Glycosylation of b1-adrenergic receptors regulates receptor surface expression and dimerizationq
 

Summary:  the b2-adrenergic receptor [15], a2A-adrenergic re- ceptor [30], and dopamine D1 receptor [31]. Con... - adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of a2... . Methods 29 (1993) 85­91. ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
45 5-HT Receptors and the Neuromodulatory Control of
 

Summary:  A/7 receptors, there was no evidence to support tonic activation of the 5-HT2A/2C receptor, since... the low expression of 5-HT2A/2C receptors in the dorsal horn (see Section 2.2.2). 3.2 5-HT1A/1B RECEPTORS... are located on ...

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
46 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being investigated... , ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 Recombinant Production and Properties of Binding of the Full Set of Mouse Secreted Phospholipases A2 to the Mouse M-Type Receptor
 

Summary:  -type receptor is discussed on the basis of our current knowledge of sPLA2 functions. Secreted phospholipases A2... 2 to the Mouse M-Type Receptor Morgane Rouault,,§ Catherine Le Calvez,,§ Eric Boilard,,§ Fanny... ReceiVed NoVember 29, 2006 ABSTRACT: To date, 12 secreted phospholipases ...

  

Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle

 

Collection: Chemistry ; Biology and Medicine

 
48 International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors
 

Summary:  receptors to specific G proteins was initially inferred from indirect evidence [measurement of intracellular... International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 Conserved waters mediate structural and functional activation of family A (rhodopsin-like)
 

Summary:  , engineered A2A-adenosine, 1- and 2-adrenergic receptors, permits comparative analysis of features common... (omitting the T4 lysozyme amino acid sequence present in mutant 2-adrenergic receptor and A2A... identity, mutant ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
50 The influence of transport on the kinetics of binding to surface receptors: application to cells
 

Summary:  a cell that has RTA free receptors. When 1 ) a2~ke da2DY tà % 3a~ke d. From eq. (12) we estimate... the concentration of free receptors on the cell surface. For example, if A is measured in cm2 , then R is measured... the distance of a cell radius, ...

  

Source: Coombs, Daniel - Department of Mathematics, University of British Columbia

 

Collection: Mathematics

 
51 Proc. Nail. Acad. Sci. USA Vol. 83, pp. 2345-2349, April 1986
 

Summary:  ,, a2, a3, and a4 are constants that give the 'he values ofthe relative contributions of each receptor... in this manner. T weights used in C (a, = 0.11; a2 = 0.20; a3 = 0.09) from the rate constants according... to the formulae: = (a2 - AO/RT)/k2 ...

  

Source: Goldbeter, Albert - Faculté des Sciences, Université Libre de Bruxelles

 

Collection: Biology and Medicine

 
52 Cys-loop receptors: new twists and turns
 

Summary:  -277 of the g-aminobutyric acid type A receptor a2 subunit define agonist efficacy and potency. J. Biol... Cys-loop receptors: new twists and turns Henry A. Lester1 , Mohammed I. Dibas1 , David S. Dahan2... atomic-scale or near-atomic-scale structures of receptors in the `Cys-loop' ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
53 Provided for non-commercial research and educational use only. Not for reproduction, distribution or commercial use.
 

Summary:  pathway for diffusible ligands. The structure of an engi- neered human A2A adenosine receptor in complex... ­13], engineered expressed monoaminergic turkey 1AR [14], engineered expressed human A2A adenosine receptor [15... engineered human ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
54 BRADSHAW 978-0-12-374145-5 00388 Multi-Pass Receptors
 

Summary:  - neered human A2A adenosine receptor in complex with the subtype specific antagonist ZM241385 provides... a number of additional surprises. The ligand binds to the A2A ade- nosine receptor in an extended... ] Expressed engineered human ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
55 1999 Macmillan Magazines Ltd 7. Carter, C. S. et al. Anterior cingulate cortex, error detection, and the on-line monitoring of
 

Summary:  (a2A-D79N)21 . Thus, we measured plasma noradrenaline levels in mice de®cient in a2-receptors... ................................................................. Two functionally distinct a2-adrenergic ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
56 *National Institute of Child Health and Human
 

Summary:  - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... and locomotor depressant effects85 . The most well-known signal transduction mecha- nism for A2A receptors... is the ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
57 nature neuroscience volume 1 no 3 july 1998 185 Recent studies suggest that tyrosine kinases are important for
 

Summary:  M EDTA to that in the absence of EDTA is a measurement of tonic inhibi- tion of NMDA-receptor currents... . p 1a/2A (10), P 1aC744,798A/2A (5), l 1b/2A (9), L 1bm207­211/2A (6). (d) Correlation between... on the Src's potentiation of whole-cell NR1/NR2A- ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
58 Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India
 

Summary:  the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... molecule. Receptors for ATP have been cloned and characterised, including seven P2X ionotropic and eight P2... Y metabotropic receptor subtypes, as well as four subtypes of P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
59 Constitutive Dimerization of the G-Protein Coupled Receptor, Neurotensin Receptor 1, Reconstituted into Phospholipid Bilayers
 

Summary:  ) receptors per 10,000 A° 2 . In a previous in vivo study of the b-adrenergic-receptor GPCR fused... ; 15 h). Receptor density was derived by measurement of the position of recon- stituted bands... both set to a 2.5-nm bandpass. Before the fluorescence ...

  

Source: Watts, Anthony - Biomembrane Structure Unit, Department of Biochemistry, University of Oxford

 

Collection: Biology and Medicine

 
60 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  as GRIP1, TIF2 and NCoA-2) [216,71] and SRC-3 (AIB1, TRAM-1, p/CIP, ACTR and RAC3) [6,194]. The SRC family... 's personal copy Review Who's in charge? Nuclear receptor coactivator and corepressor function in brain... : Steroid receptor coactivator-1 (SRC-1) Steroid hormones Estrogen ...

  

Source: Tetel, Marc J. - Department of Biological Sciences, Wellesley College

 

Collection: Biology and Medicine


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61 STUDIES ON THE ROLE OF THE N-TERMINAL DOMAIN OF NR1 IN THE REDOX MODULATION OF NR2A-CONTAINING NMDA RECEPTORS
 

Summary:  -CONTAINING NMDA RECEPTORS by Greta Ann Herin B.S. in Psychology, Kansas State University, 1993 B... IN THE REDOX MODULATION OF NR2A-CONTAINING NMDA RECEPTORS Greta Ann Herin, PhD University of Pittsburgh, 2003... The NMDA receptor is the subject of intense study due to its critical role in many neuronal processes

  

Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh

 

Collection: Biology and Medicine

 
62 NPY signaling through Y1 receptors modulates thalamic oscillations
 

Summary:  of the three Y receptor agonists. Fig. 2A2, B2 and C2 shows representative sweeps within these recordings... ). Effects of the Y1 receptor agonist Leu31Pro34NPY (A1 and A2), the Y2 receptor agonist PYY3­36 (B1 and B2... capsule ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
63 Bovine Papillomavirus E5 Protein Induces the Formation of Signal Transduction Complexes Containing Dimeric Activated
 

Summary:  Dimeric Activated Platelet-derived Growth Factor Receptor and Associated Signaling Proteins* (Received... (PDGF) recep- tor, resulting in constitutive activation of the receptor and cell growth transformation... , activated PDGF receptor complexes were separated from monomeric, inactive receptor. Rapidly ...

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
64 International Union of Pharmacology. XXXV. The Glucagon Receptor Family
 

Summary:  International Union of Pharmacology. XXXV. The Glucagon Receptor Family KELLY E. MAYO, LAURENCE J... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168 II. Secretin receptor... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

  

Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

 

Collection: Biology and Medicine

 
65 Behaioural Pharmacology 2001; 00:1 10 REVIEW Serotonin receptors in mood disorders: a combined1A
 

Summary:  receptors. These may include 5-HT , 5-HT and 5-HT receptors, since2A 2C 3 selective antagonists acting... , 5-HT , 5-HT , etc. . Serotonergic neurons2A 2C 3 have a slow and spontaneous rhythmic activity of 4... KH, Bench CJ, Rabiner EA, Messa C et al. Z .2000 . Brain ...

  

Source: Sibille, Etienne - Center for the Neural Basis of Cognition & Department of Psychiatry, University of Pittsburgh

 

Collection: Biology and Medicine

 
66 q 2001 International Society for Neurochemistry, Journal of Neurochemistry, 76, 18871894 1887 Journal of Neurochemistry, 2001, 76, 18871894
 

Summary:  construct for the third intracellular loop of human a2A- adrenergic receptor (a2-AR-I3L) was generously... and a2-adrenergic receptors. J. Biol. Chem. 272, 17836±17842. Zhang J., Ferguson S. S., Barak L. S... was carried out ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
67 Ghrelin and Growth Hormone (GH) Secretagogues Potentiate GH-Releasing Hormone (GHRH)-Induced
 

Summary:  -subunits in the synergistic activation of PKA signaling by the D2 dopamine and A2 adenosine receptors (51... epitope-tagged GHRH receptor (34). An Elk-1 reporter gene-based assay was used to measure GHS activation... receptor and the flag epitope-tagged GHS recep- ...

  

Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

 

Collection: Biology and Medicine

 
68 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  the measured KD of these agonists for A1/A2a receptors, whereas the EC50 for Cl-IB-MECA was significantly... of this process are known. Western blot analysis established that all four aden- osine receptors (A1, A2a, ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
69 Characterization of binding sites of a new neurotensin receptor antagonist, [3
 

Summary:  distribution of a new nonpeptide antagonist of neurotensin receptors, [3 H]SR 142948A (2... A (2-{[5-(2,6-dimethoxyphenyl)-1-(4-(N-(3-dimethylaminopropyl)-N- methylcarbamoyl)-2-isopropylphenyl... experiments, rat brain homogenates were incubated with [3 H]SR 142948A ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
70 Muscarinic Receptor Subtypes in the Lateral Geniculate Nucleus: A Light and
 

Summary:  the DLG. Neurons that were positive for the m2 receptor measured approxi- mately 10.9 1.5 µm in caliper... of a cytoplasmic laminated body associated with heavy deposits of m3 label. Scale bars 3 µm in A, 2 µm in B... Muscarinic Receptor Subtypes in the Lateral Geniculate Nucleus: A ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
71 Dopamine Receptors in a Songbird Brain Lubica Kubikova,1,2* Kazuhiro Wada,1,3
 

Summary:  Dopamine Receptors in a Songbird Brain Lubica Kubikova,1,2* Kazuhiro Wada,1,3 and Erich D. Jarvis1... transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene... in mammalian brain are modulated by dopamine receptors. Here we cloned from zebra finch brain cDNAs of all

  

Source: Jarvis, Erich D. - Department of Neurobiology, Duke University

 

Collection: Biology and Medicine

 
72 news and views nature neuroscience volume 2 no 3 march 1999 201
 

Summary:  & Weiss did it. The main problem that besets binding measurements has been that almost all receptors... contribution from the doubly (A2R), or triply occupied (A3R) forms, simply because there is not much of either... news and views nature neuroscience · volume 2 no 3 · march 1999 201 ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
73 J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW
 

Summary:  in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... -dependentcytosolic phospholipase A2 activity in primary sensory neurons is claimed to be a key event in neuropathic pain (Tsuda ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
74 Improved docking, screening and selectivity prediction for small molecule nuclear receptor modulators using conformational
 

Summary:  energy and numerical errors. It is calculated as follows: Ebind ¼ DEIntFF þ TDSTor þ a1DEHBond þ a2... . Table 3 Accuracy of VLS in single receptor mode measured by their ROC AUC values Receptor PDB ID ROC... and multiple receptor modes, as ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
75 1999 Macmillan Magazines Ltd Kainate-receptor-mediated
 

Summary:  with conA (2 mM) reduced the decay of kainate currents during 1-Hz stimulation. Asterisk indicates P , 0... © 1999 Macmillan Magazines Ltd Kainate-receptor-mediated sensorysynaptictransmission in mammalian... receptors that directly gate ion channels, namely receptors for AMPA ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
76 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... to the Gi/o family of G proteins inhibiting cyclic AMP (cAMP) production, whereas A2A and A2B ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
77 The state of GPCR research in 2004 (20 Questions) Nat Rev Drug Discov. 2004 Jul;3(7):575, 577-626.
 

Summary:  AMP production in discrete brain areas, and discovered a number of receptors, including adenosine A2 receptors... fluorescence assay that measured receptor-stimulated guanine-nucleotide exchange. Such an assay would... to measure ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
78 Kinetic Differences between Synaptic and Extrasynaptic GABAA Receptors in CA1 Pyramidal Cells
 

Summary:  versus Extrasynaptic GABAA Receptors #12;ing. For the length measurements, the transition from soma... concentrations and for whole-cell IPSCs tRise (msec) Dec,1 (msec) A1 (%) Dec,2 (msec) A2 (%) Dec,3 (msec) A3... Kinetic Differences between Synaptic and Extrasynaptic GABAA Receptors in ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
79 Coupling of the nucleotide P2Y4 receptor to neuronal ion channels Alexander K. Filippov, 2
 

Summary:  noradrenaline (10 mM) inhibited ICa via a2 receptors by 41.8+4.1% on the same cells. Surprisingly, in perforated... .4+2.4% (Figure 1C). This eect was almost as great as the abolition of a2-adrenergic inhibition of Ca2+ current... receptor was found to be too weak to ...

  

Source: Brown, David - Department of Neuroscience, Physiology and Pharmacology, University College London

 

Collection: Biology and Medicine

 
80 Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian-Specific
 

Summary:  copy. Three of these pairs (pufferfish a2, b4 and r1) are composed of very similar genes that have... Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian... in the central nervous system (CNS) of both invertebrates and vertebrates. Receptors of this neurotransmitter

  

Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine


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81 Structure of human follicle-stimulating hormone in complex with its receptor
 

Summary:  to an elongated, curved receptor. The buried interface of the complex is large (2,600 A° 2 ) and has a high charge... ) and Y124 of the receptor. Y88 also forms a hydrogen bond with E99 of FSHR. Altogether, 106 A° 2... ,600 A° ...

  

Source: Hendrickson, Wayne A. - Department of Biochemistry and Molecular Biophysics, Columbia University

 

Collection: Biology and Medicine

 
82 Heterogeneous Conductance Levels of Native AMPA Receptors T. Caitlin Smith,1 Lu-Yang Wang,2 and James R. Howe1,2
 

Summary:  A), (2) models in which each open state was connected to every other open state (class B), and (3... Heterogeneous Conductance Levels of Native AMPA Receptors T. Caitlin Smith,1 Lu-Yang Wang,2... receptors can affect information processing in neurons by influencing the amplitude and kinetics of synaptic

  

Source: Howe, James R.- Department of Pharmacology, Yale University

 

Collection: Biology and Medicine

 
83 Receptor noise as a determinant of colour Misha Vorobyev1*
 

Summary:  is by a metric tensor in the receptor space, g, which is de¢ned as the inverse of R, i.e. g RÀ1 . (A2... the noise level in n colour channels. Receptor spectral sensitivities can be measured electro... in the remaining three cones. Electroretinogram measurements ...

  

Source: Sussex, University of - Centre for Computational Neuroscience and Robotics

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
84 Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure in Endotoxemic Mice
 

Summary:  . This study tested whether TxA2 receptor block- ade, with the use of TxA2 receptor knockout (TP-KO) mice... of our study was to assess the role of TxA2 and TP receptor activation during basal resting ...

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
85 Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor [Journal Home Page] [Search the Journals] [Table of Contents] [PDF version of this article] [Download
 

Summary:  Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor... Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor the binding of different... Phospholipase ...

  

Source: Gelb, Michael - Departments of Chemistry & Biochemistry, University of Washington at Seattle

 

Collection: Chemistry ; Biology and Medicine

 
86 894 nature neuroscience volume 4 no 9 september 2001 Glutamate is the most widely used neurotransmitter in the ver-
 

Summary:  the following events. (1) Glutamate binds to the S1-S2 domain of NR2A. (2) Glutamate binding leads to allosteric... neurotransmitter in the ver- tebrate central nervous system. The NMDA receptor, a subtype of glutamate receptor... ). The term `glycine-dependent desensitization' is used to describe the ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
87 Department of Chemistry Sponsor: National Institute of Neurological Disorders and Stroke
 

Summary:  glutamate receptors has been implicated as a leading contributor to a number of neurological diseases... to dampen the excessive receptor activity has been a long pursued therapeutic strategy. 2,3-Benzodiazepine... derivatives, also known as GYKI compounds, are inhibitors of AMPA receptors, and they represent a class

  

Source: Knuth, Kevin H. - Department of Physics, State University of New York at Albany

 

Collection: Physics

 
88 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... Neuropharmacology 43 (2002) 1313­1323 www.elsevier.com/locate/neuropharm P2 receptors in the murine... . The localization of P2Y1, P2Y2, P2Y4, P2X1 and P2X2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
89 Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
 

Summary:  pathways activated by these receptor types include: phospholipase A2, Ca2+ sensitive ion channels, protein... .R., Shanley, T.P., 2002. The A2A receptor mediates an endogen- ous regulatory pathway of cytokine expression... of phospholipases ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
90 Subunit-Specific Action of an Anticonvulsant Thiobutyrolactone on Recombinant Glycine Receptors Involves a Residue in the
 

Summary:  is abbreviated by A2 ; see Fig. 4). Initial studies of glycine receptors implicated residues in the M2 region... of the function of rdl A2 S receptor has shown that several alterations in activation by GABA also occur (Zhang et... that a point mutation, rdl ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
91 Nicotine binding to brain receptors requires a strong cationp interaction
 

Summary:  of the a4b2 receptor. We now report that the A2B3 and A3B2 forms of the a4(L99A)b2 receptor show markedly... , if not exclusively, a consequence of changes in binding. Fluorination of TrpB of the a4b2 (A2B3) receptor primarily... , there are two ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
92 Binding, gating, anity and ecacy The nature of the problem
 

Summary:  with the same agonist, on the same mutant receptor (Figure 1b) shows that the measured anity for the binding... to measure independently both ligand receptor anity (by ligand binding techniques) and biological activity... if depolarization or some later response is being measured). ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
93 The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1
 

Summary:  Kuryatov et al., 1994 (EC50 measured in oocytes expressing NR1/NR2B receptors). d Hirai et al., 1996 (EC50... measured in oocytes expressing NR1/NR2B receptors). e Wafford et al., 1995 (EC50 measured from oocytes... expressing NR1/NR2A receptors). f Williams et al., ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
94 Behavioral/Systems/Cognitive Conversion of the Modulatory Actions of Dopamine on
 

Summary:  the effects of dopamine and D2-like receptor agonists on spinal cord excitability as measured... of both MSR and the longer- latency reflexes were similar between WT and D3KO mice (Fig. 2A1,A2). A rank... generally led to an increase in MSR amplitude (Fig. 3A2). ...

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
95 Modified Receptor Internalization upon Co-expression of 5-HT1B Receptor and 5-HT2B Agnes Janoshazi*, Maud Deraet*, Jacques Callebert, Vincent Setola, Silke Guenther, Bruno
 

Summary:  as an additional means of measuring receptor internalization. Our results indicate that the stimulation of 5-HT1B... fluorescent protein tagged or non-tagged receptors yielded a Bmax approximately 60% of that measured... to measure internalization kinetics of the tagged ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
96 0026-895X/951030582.06$3.00/0 Copyright t by The American Society for Pharmacology and Experimental Therapeutics
 

Summary:  ) neuron- s,whereas AMPA receptor current was measured in cultured neurons from rat cerebral cortex... 53655 (A, 2 p.M; B, 200 p.M). C and D, filled bars, application of antagonists alone, at -60 mV (52466... -Preferring Receptors by 2,3-Benzodiazepines TIMOTHY J. WILDING and JAMES E. ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
97 JournalofPhysiologyPhysiologyinPress Acetylcholine (ACh) is the major endogenous ligand for
 

Summary:  to desensitization, we wondered what effect this has on receptor recovery. To measure recovery, cells were... . It is known that the a4b2 receptor has a very high affinity for agonists when equilibrium binding is measured... for nicotinic receptors, while nicotine is an example of a ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
98 Tracking transmitter-gated P2X cation channel activation in vitro and in vivo
 

Summary:  attempt to measure P2X2 receptor activation by FRET provided readouts of a conformational change... for ATP- evoked current measurements at P2X2-cam or wild-type P2X2 receptors measured with patch... of the receptors. P2X2-cam receptor activation ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
99 High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic
 

Summary:  in the top panels. The amplitude of the NMDA receptor component was measured 30 ms after the onset... antagonize kainate receptors. We recorded the mixed AMPA/NMDA EPSC and measured the NMDA receptor component... with 50 nM kainate. Calibration 50 pA, ...

  

Source: Contractor, Anis - Department of Physiology, Northwestern University

 

Collection: Biology and Medicine

 
100 JOURNAL OF CELLULAR PHYSIOLOGY 200:309317 (2004) Significance of N-Methyl-D-Aspartate (NMDA)
 

Summary:  of NMDA receptors. Therefore, we measured NMDA-evoked Ca2þ response. There have Fig. 5. Squamous cell... and Taichman, 1994). These suprabasal cells are also found to express atypical integrins (a2, a3, a6, and b1... ) Receptor-Mediated Signaling in Human Keratinocytes WALTER K. NAHM,1,2 ...

  

Source: Bear, Mark - Picower Institute for Learning and Memory & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine


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