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Sample search results for: a2 adenosine receptors

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1 Adenosine-Mediated Presynaptic Modulation of Glutamatergic Transmission in the Laterodorsal Tegmentum
 

Summary:  , at least in part, by the activation of additional adenosine receptor subtypes. Are adenosine A2 receptors... of adenosine (Fig. 5B) might have resulted from the coactivation of A2 ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
2 0022.3565/87/2423-0882S00.00/0 THE JOURNALor PHARMACOLOGYAND EXP!JUNENTALTHERAPEIITICS
 

Summary:  . A2 adenosine receptors. Blockade of the negative chronotropic effect of bolus Lv. injections of 2... as an index of activity at A2 receptors. Inaddition, blockade of the potentiating effect of adenosine... the bradycardiac ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
3 Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle
 

Summary:  . Prior studies have demonstrated that adenosine A2B receptors regulate production... laboratory and others indicate that adenosine A2A receptors play an important role... ...

  

Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
4 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  surface adenosine receptors (12). Four subtypes of adenosine receptors have been defined, A1, A2a, A2b... of this process are known. Western blot analysis established that all four aden- osine receptors ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
5 Behavioral/Systems/Cognitive A Circadian Clock and Light/Dark Adaptation Differentially
 

Summary:  by the presence of retinal adenosine metabolic pathway enzymes and receptor subtypes A1 and A2A and by the effects... ) Adenosine in vertebrate retina: localization, receptor characterization, and function. Cell Mol Neurobiol 11... Adenosine in ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
6 In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to
 

Summary:  activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... and 4 the yeast system is exploited to study inverse agonism of the human adenosine A2B ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
7 Biochemistry Insect Biochemistry and Molecular Biology 35 (2005) 381389
 

Summary:  -[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J. 14, 2065­2074. Heming, B... insects or Metazoa. The expression of most of the Drosophila adenosine deaminases (ADGF-A2,-B,-C and E... .J., Christoffel, ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
8 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  July 15, 2004; doi:10.1152/ ajpgi.00164.2004.--Adenosine, acting through the A2b receptor, in- duces... of the A2b receptor may be required for its signaling. vesicle; adenosine; vesicle-associated membrane... to be involved ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
9 0022.3565/86/2362.0350S02.oo/0 THE JOURN"L or PH..R COLO<:Y..,..D EXPF.H'''ENT''L THER"PEl'TIC~
 

Summary:  that an adenosine receptor resembling the A2 subtype mediates the potentiation by adenosine of sympathomimetic... .C.: Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
10 The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
 

Summary:  endogenous P2Y receptors in addition to the P1 adenosine receptors A2A and A2B, which might complicate... are influenced by a physical interaction between GPR80/GPR99 and endogenous P2Y or A2B ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
11 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... principally P2Y1, P2Y2 and A2 receptors, which mediate vasorelax- ation to ADP, UTP/ATPand ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
12 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being investigated... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
13 Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury
 

Summary:  demonstrated a potent cytoprotective role of adenosine A1, A2A, and A3 receptors in ischemia and reperfusion... mediates protection is not the same. The adenosine A3 receptor, but not the A1 or A2A ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
14 The birth and postnatal development of purinergic signalling G. Burnstock,1
 

Summary:  through adenosine receptors. This suggestion was based largely on the observation that adenosine and its... that several factors including adenosine receptors, NO and KATP channels contribute, and may act... vesical parasympathetic ganglia, purines suppressed synaptic transmission ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
15 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  Signaling The Periphery Adenosine A1, A2A, A2B, and A3 receptors (ARs) are all present at peripheral sites... signaling in inflammatory states. Adenosine A2B and A3 receptors have not ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
16 Biochemistry Insect Biochemistry and Molecular Biology 37 (2007) 318329
 

Summary:  for adenosine and adenosine receptor agonist binding in point mutation experiments for the human A1, A2A and A3... 50 values for adenosine-induced cAMP response of the human A1, A2A, ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
17 ADENOSINE, PROLONGED WAKEFULNESS, AND A1-ACTIVATED NF-UB DNA BINDING IN THE BASAL FOREBRAIN OF THE RAT
 

Summary:  to adenosine. Other investigators have shown that infusion of the A2A receptor agonist 4-[2-[[6-amino-9-(N... deprivation on adenosine A1 and A2a receptor binding and mRNA in rat brain. World Federation Sleep Research... ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
18 Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion
 

Summary:  roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus... receptors to decrease neurotransmitter release or A2A receptors to potentiate neuro- transmitter release... release are ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
19 Purinergic Signaling and Vascular Cell Proliferation and Death Geoffrey Burnstock
 

Summary:  established.1,2 P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B, and A3) have been identified... . Adenosine inhibits vascular smooth muscle cell prolifera- tion by A2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
20 The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle
 

Summary:  conditions, while adenosine A2 receptor-mediated responses were not sensitive to temperature changes... for responses mediated via A1-receptors but not A2-receptors. Br. J. Pharmacol. 84, 407­415. Burnstock, G., 1996... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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21 Purinergic regulation of vascular tone and remodelling
 

Summary:  ; Burnstock, 2007a). P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B 63 Autonomic & Autacoid... of ATP acts on P1 (A2) receptors to inhibit cell proliferation [via elevation of cyclic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
22 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... , induced [Ca2+ ]i elevation via activation of A2A receptors [77]. In cultured mouse astrocytes ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  cells were stably transfected with a double hemagglutinin-tagged (HA-tagged) dog adenosine A2A receptor... for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
24 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  Title Page Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co... ; Accepted: Aug 12, 2011 #12;Abstract The adenosine A2A receptor (A2AR) is a ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
25 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... are ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
26 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Encyclopedia of Neuroscience (2009), vol. 1, pp. 105-113 Author's personal copy #12;A2A (P1) receptors... .deaminase Inosine Smooth muscle receptors P2 Purinoceptor 5 -nucleo- ATP resynthesis Adenosine Adenosine uptake... vasoconstriction (+) via P2X ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 *National Institute of Child Health and Human
 

Summary:  - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... roles are not fully known. A1 , A2A , A2B and A3 adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
28 RESEARCH PAPER Role of ATP and related purines in inhibitory
 

Summary:  through muscle A2A receptors after breakdown to adenosine, and P2Y1 receptors after breakdown to ADP... ; adenosine; P2Y1- and A2A-receptors; pig urinary bladder neck Abbreviations: ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
29 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system after chronic A1 receptor
 

Summary:  Chapter 7 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system... these lines, there are data suggesting cross-talk between the adenosine and serotonin receptor systems... of the adenosine A1 receptor agonist N6 ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 Samenvatting In dit proefschrift wordt een gecombineerde aanpak besproken om aan de hand van de
 

Summary:  adenosine A2B receptor de constitutieve activiteit van aan G-eiwitten gekoppelde receptoren (GPCRs) te... wordt dit gistsysteem gebruikt om invers agonisme van de adenosine A2B receptor van de mens te... . In hoofdstuk 5 is de ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
31 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  , adenosine (ADO) also appears to act on sensory terminals, probably directly through P1(A2 ) receptors... disorders, highlighting specific purinergic receptor subtypes, most notably A2A , P2X4 and P2X7 ,that might... in rodents, which is ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
32 The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 11 2417-2427
 

Summary:  ). The immunoregulatory attributes of adenosine are mediated via four transmembrane adenosine receptors: A1, A2A, A2B... and neutrophils express all four adenosine receptors, whereas B cells harbor only ...

  

Source: Chicago, University of - Department of Microbiology

 

Collection: Biology and Medicine

 
33 Structure based prediction of subtype-selectivity for adenosine receptor antagonists
 

Summary:  into the structural basis of ligand subtype selectivity within the family of adenosine receptors (AR: A1, A2A, A2B... protein-coupled receptor; AR, adenosine receptor; ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
34 Endothelium-Derived Vasoconstriction by Purines and Pyrimidines
 

Summary:  , prostaglandin H2, thromboxane A2, and superoxide anions.6,7 To¨lle et al1 present compelling evidence... by To¨lle et al1 claims to show for the first time that adenosine 5 -tetraphosphate (AP4) is released... , that AP4 is the most potent mediator of vascular smooth muscle constric- tion via P2X1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
35 ATP signalling in epilepsy Ashwin Kumaria & Christos M. Tolias &
 

Summary:  effects [11, 12]. On the other hand, Zeraati et al. [13] elegantly showed that A2A receptors in the CA1... . Epilepsia 46:166­173 13. Zeraati M, Mirnajafi-Zadeh J, Fathollahi Y et al (2006) Adenosine A1 and A2A... and is believed to inhibit distant synapses by acting ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
36 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  t Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests... receptor function [10,32]. Adenosine type A1 and A2A receptors on glutamatergic terminals play a ...

  

Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University

 

Collection: Biology and Medicine

 
37 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  ATP Adenosine P2 receptor P1 receptor The inhibitory effects of ATP and adenosine on the nerve... 2 receptor antagonist, PPADS (10 M), did not significantly change the inhibitory effect of adenosine... was antagonized by 8-SPT and not affected by PPADS, which ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
38 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors... 1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
39 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... with the excitatory actions of ATP on nerve cells. Adenosine (P1) receptor activation can inhibit ATP release. ATP... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
40 Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells
 

Summary:  , and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest... growth factor receptor KDR/Flk gene expression through adenosine A2 recep- tors in retinal capillary... , Nakashima ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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41 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... adenosine. This is suggestive of P2Y1-mediated relaxation and perhaps a further P2Y receptor subtype... classification of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
42 PURINERGIC SIGNALING IN ATHEROSCLEROSIS AND RESTENOSIS Geoffrey Burnstock, Autonomic Neuroscience Centre, Royal Free and University
 

Summary:  in angiogenesis [26]. Endothelial cell proliferation is mediated by A2A and A2B receptors and some... of the mitogenic effects are mediated via the modulation of VEGF signaling. There is evidence that A2B receptors... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
43 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  between adenosine and dopa- mine receptors, the A1R/mGluR1 and A2AR/mGluR5 in- teractions facilitate... . (2003) Adenosine A2A-dopamine D2 receptor- receptor heteromerization: qualitative and ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
44 Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation
 

Summary:  receptors. Adenosine acting through A2 receptors inhibits smooth muscle proliferation but stimulates... ,23­25 and it is currently recognised that there are four subtypes of P1 receptors (A1, A2A, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
45 Double-Stranded RNA Adenosine Deaminases ADAR1 and ADAR2 Have Overlapping Specificities
 

Summary:  . Calculations that include all adenosines give a value of 28% deamination for both enzymes. hA2, hADAR2; xA1, x... I site immediately downstream of the TOP2 gene has been replaced with a unique XhoI site. pSc[hA2a-H6... in yeast (18). BCY123 colonies containing ...

  

Source: Bass, Brenda L. - Departments of Biochemistry & Human Genetics, University of Utah

 

Collection: Biology and Medicine

 
46 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... A2 receptors; however, it might also act (broken arrow) to potentiate P2X3 or ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India
 

Summary:  the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... Y metabotropic receptor subtypes, as well as four subtypes of P1 receptors sensitive to adenosine... while ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
48 Genetics of caffeine consumption and responses to caffeine Amy Yang & Abraham A. Palmer & Harriet de Wit
 

Summary:  and A2A receptors (Daly et al. 1983). Adenosine receptors are G-protein-coupled receptors locat- ed... and humans have implicated polymorphisms in adenosine A1 and A2A receptors in ...

  

Source: Das, Soma - Department of Human Genetics, University of Chicago; Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago

 

Collection: Biology and Medicine

 
49 pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799
 

Summary:  recently of human A2A adenosine receptor35 (A2AAR) in com- plex with antagonist 1 (ZM24138536 ), open... , adenosine receptor; A2AAR, subtype ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
50 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... . Blockade of A2A (P1) receptors antagonises parkinsonian tremor in the rat tacrine model by actions... on specific ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
51 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  selectivity of P2X receptors, and why adenosine, polyphosphate or other nucleotides such as GTP and UTP... P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of receptors

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
52 Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  , two subtypes of the P1 (adenosine) receptor were recognised [5,6], but it was not until 1985... activate phospholipases A2, C and D, MEP/MAP kinase, Rho-dependent kinase and tyrosine kinase, as well... Theuse of theophylline, an adenosine receptor antagonist, as an ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
53 Conserved waters mediate structural and functional activation of family A (rhodopsin-like)
 

Summary:  , engineered A2A-adenosine, 1- and 2-adrenergic receptors, permits comparative analysis of features common... (omitting the T4 lysozyme amino acid sequence present in mutant 2-adrenergic receptor and A2A-adenosine... identity, ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
54 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... /ADP, respectively), was proposed (246). At about the same time, two subtypes of the P1 (adenosine) receptor were... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
55 Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock
 

Summary:  , Le Moine C, Fisone G, et al. (1999): Distribution, biochemistry and function of striatal adenosine A2... so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... :85-108 [MEDLINE] Ferre S, Fredholm ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
56 A Role for Adenosine Deaminase in Drosophila Larval Development
 

Summary:  functions by binding to G protein-coupled adenosine receptors (A1, A2a, A2b, and A3 in mammals) that can... the adenosine receptor (AdoR), but fat body disintegration, which is promoted by action of the hemocytes, seems... ...

  

Source: Gibson, Matt - Stowers Institute for Medical Research; Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
57 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674 ­ 678. 28 Sun... by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
58 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674 ­ 678. 28 Sun... , complementary DNAs (cDNAs) encoding two different P1 receptor subtypes (A1 and A2) were isolated [20], and... , shortly after, the ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
59 REVIEW ARTICLE The journey to establish purinergic signalling in the gut
 

Summary:  of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system. J Comp Neurol 2001; 439: 46... ­64. 42 Gao N, Hu HZ, Liu S, Gao C, Xia Y, Wood JD. Stimulation of adenosine A1 and A2A ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
60 Evolutionary origins of the purinergic signalling system G. Burnstock1
 

Summary:  the larvae of the blowfly Calliphora vicina (Magazanik & Fedorova 2003). An A2 adenosine receptor subtype... connected by commisures. Early studies showed adenosine to have a modulatory action via A1 and A2 receptors... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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61 Purinergic signalling *Geoffrey Burnstock
 

Summary:  . Adenosine, via A2A receptors, has a protective effect in a rat model of Parkinson's disease, perhaps... /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
62 Specificity of RNARNA helix recognition Daniel J. Battle* and Jennifer A. Doudna
 

Summary:  unpaired adenosine residues dock into the minor groove of a receptor helix. This A-minor motif, potentially... of the adenosine 2 -OH relative to the 2 -OH groups of the receptor base pair, with the first position... of the receptor base pair defined as the residue closest to the 2 -OH ...

  

Source: Doudna, Jennifer A. - Department of Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine

 
63 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... /or astrocytes that release adenosine directly [18]. Receptors for purines and pyrimidines Separate membrane... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
64 Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila
 

Summary:  , encoding ADGF-A and ADGF-B, as well as ADGF-A2, previously re- ported as male-specific insect... -derived growth factor, or MSI (12). The ADGF-A2 gene is included within the 5 intron of the ADGF-A gene. Two... in the adult only in the male abdomen, possibly reflecting testis-specific expression as described ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
65 REVIEW ARTICLE Chemokine receptors and other G protein-coupled receptors
 

Summary:  of invertebrate rhodopsin, b1-adrenergic and b2-adrenergic receptors and the A2A-adenosine receptor have been... -adrenergic and b2-adrenergic receptors, and most recently, the structure of the A2A ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
66 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... ., 2001. Activation of protein kinase A and atypical protein kinase C by A2A adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
67 J Physiol 589.2 (2011) pp 283295 283 The dynamics of single spike-evoked adenosine release
 

Summary:  , the modulation of adenosine release by specific G-protein coupled receptor agonists strongly suggests... mediated by glutamate receptor activation In control conditions (absence of 4-AP), adenosine release... of the adenosine release stems from AMPA receptor ...

  

Source: Richardson, Magnus - Systems Biology Centre, University of Warwick

 

Collection: Biology and Medicine

 
68 Ecto-5V-nucleotidase activity in brain membranes of zebrafish (Danio rerio)
 

Summary:  ) 203­207206 #12;A2A adenosine receptors (Magalha~es-Cardoso et al., 2003). In summary, considering... modifies cell functioning by operating G-protein-coupled receptors (A1, A2A, A2B, A3), which can ...

  

Source: Eizirik, Eduardo - Centro de Biologia Genômica e Molecular da Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul

 

Collection: Environmental Sciences and Ecology

 
69 Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate
 

Summary:  protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate in urological... purinergic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
70 Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
 

Summary:  .F., Schwarzschild, M.A., Fredholm, B.B., Urade, Y., and Hayaishi, O. (2005). Adenosine A2A, but not A1, receptors... ), or of caffeine (Figures 3G and S11), which is known to act via A2A receptors in this behavior (Huang et al., 2005... that by ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
71 INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE Olfactory Receptor Interactions
 

Summary:  receptors, and A2A adenosine receptor. These four receptors were further- more found... INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE Olfactory Receptor Interactions with Other Receptors... Olfactory ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
72 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  ; PKA, protein kinase A; PKC, protein kinase C; PLA2, phospholipase A2; PLC, phospholipase C; PLD... JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165­205, 2004 Dopamine Receptor... The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
73 lagC-Null and gbf-Null Cells Define Key Steps in the Morphogenesis of Dictyostelium Mounds
 

Summary:  or counterclockwise (Figs. 2a­2c) about a center point (61/66 mounds). Cells normally moved per- pendicular... of adenosine to the class of receptors (Kd 350 m) noncompetitively inhibits cAMP binding to cAMP receptors... be overcome by the addition of adenosine, ...

  

Source: Firtel, Richard A. - Division of Biological Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
74 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  (hb2AR) (Cherezov et al., 2007) and adenosine A2A receptor (hAA2AR) (Jaakola et al., 2008)]. Moreover... . In addition, we predicted structures for the human A1, A2B, and A3 adenosine receptors (ARs) and used... /mol) of ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
75 The Uroepithelial-associated sensory web , E Balestreire1
 

Summary:  family ErbB1­3 receptors,17 A1, A2a, A2b, and A3 adenosine receptors,18 a- and b-adrenergic receptors,19... , we observe that adenosine, most likely acting through A1 and ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
76 Cellular/Molecular Calcium Increases in Retinal Glial Cells Evoked by Light-
 

Summary:  that adenosine potentiation of Mu¨ller cell Ca2 responses is mediated primarily by A2B receptors, in agreement... -induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes. Br J Pharmacol ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
77 Prediction of the 3D structure of rat MrgA G protein-coupled receptor and identification of its binding site
 

Summary:  and hA2AA) receptors and human P2Y1 purinergic (hP2Y1) receptor. These receptors all bind adenosine... compare the binding site of adenine to rat MrgA with the binding site of human A1 and A2A adenosine ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
78 Historical review: ATP as a neurotransmitter
 

Summary:  neuroprotective agents in the cortex, hippocampus and cerebellum. Blockade of A2A (P1) receptors antagonises... to adenosine by ectoenzymes, so that some of the actions of ATP were directly on P2 receptors, whereas others... were due to the indirect action of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
79 Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety
 

Summary:  by activating group I P2X receptors. Diadenosine polyphosphates (ApnAs) and adenosine polyphospho guanosines... 1.30 1.06­1.67 0.8 0.1 Ap5A 2.89 2.40­3.47 1.0 0.1 Ap5G 2.76 2.09­3.66 1.0 0.1 Ap6A 4.32 3.57­5.23 1... hexaphosphate (AP6A) via A1-adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
80 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  phase of the reactive hyperaemia as has been shown by infusion of adenosine deaminase or a selective A2A... phase hyperaemia mediated via A2A receptors on smooth muscle cells. Red blood cells as regulators... hyperaemia via endothelial P2Y1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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81 GPCR agonist binding revealed by modeling and crystallography
 

Summary:  with recently determined agonist-bound structures of b-ad- renergic and adenosine A2A receptors reveals high... agonist binding predictions Adenosine A2A receptor (AA2AR) modeling studies [18,29] provide another... . Agonist ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
82 J Physiol 588.1 (2010) pp 9399 93 SYMPOSIUM REVIEW
 

Summary:  adenosine A2A receptors are essential for inducing LTP of NMDA-EPSCs (Rebola et al. 2008). A2A receptors may... of mossy fibres lead to the activation of NMDA, mGluR5 and adenosine A2A ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
83 Pathophysiology and Therapeutic Potential of Purinergic Signaling
 

Summary:  ). The therapeutic poten- tial of adenosine A2A receptor antagonists in Parkinson's 64 BURNSTOCK #12;disease is being... receptor activation that triggers adenosine release, leading to activation of P1 (A2A) ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London; Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Biology and Medicine ; Geosciences

 
84 ARTICLE IN PRESS Purinergic P2 receptors as targets for novel analgesics
 

Summary:  inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors on the central projections of primary... directly via P1(A2) purinoceptors; however, it also acts synergistically (broken red line) to potentiate P2... broken down by ectoenzymes to ADP (to act on P2Y1, P2Y12, and P2Y13 ...

  

Source: Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Geosciences

 
85 Purinergic P2 receptors as targets for novel analgesics Geoffrey Burnstock *
 

Summary:  ATP, adenosine (AD) also appears to act on sensory terminals, probably directly via P1(A2... as heteromultimers, and after breakdown to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2... by ectoenzymes to ADP (to act on P2Y1, P2Y12, and ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
86 ORIGINAL ARTICLE An in vivo model of melanoma: treatment with ATP
 

Summary:  S, Sitkovsky M (2006) A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad... , Dwyer K, Robson SC, Ohta A (2008) Adenosine A2A receptor antagonists: blockade of adenosinergic effects... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
87 Supporting Information Angel et al. 10.1073/pnas.0903545106
 

Summary:  ), mutant 2-adrenergic receptor (2), squid rhodopsin (3), bovine rhodopsin (4), and mutant A2A-adenosine... of G-coupled protein receptors (GPCRs). Amino acid sequences from mutant 1-adrenergic receptor (1... receptor (5) were aligned with ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
88 doi:10.1152/physiolgenomics.00068.2005 23:89-102, 2005. First published Jul 26, 2005;Physiol. Genomics
 

Summary:  inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network... Weng, and Jiang-Fan Chen. Genetic and pharmacological inactivation of adenosine A2A receptor reveals... ­102, 2005. First ...

  

Source: Weng, Zhiping - Center for Advanced Genomic Technology, Boston University

 

Collection: Biotechnology

 
89 Editorial Manager(tm) for Nuclear Medicine Communications Manuscript Draft
 

Summary:  there are still controversies on how adenosine receptors (A1, A2A, A2B, and A3) mediate the cardioprotection... and relates with the activation of adenosine receptors in rat hearts. FastSPECT GLA imaging is not only useful... ...

  

Source: Arizona, University of - Center for Gamma-Ray Imaging

 

Collection: Engineering ; Biology and Medicine

 
90 Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins,
 

Summary:  ., 2004), and strokes and cere- bral hypoperfusion (altered adenosine A2A receptor function... Receptor versus Rhodopsin. Like the 2- adrenergic receptor, the human A2A adenosine ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
91 Purines and Sensory Nerves Geoffrey Burnstock
 

Summary:  of receptors for purines and pyrimidines are available, including four subtypes of P1 (adenosine), seven... and internalization of P2Y receptors in DRG neurons (Wang et al. 2006). Adenosine 50 -O-(3-thiotriphosphate) enhances... act on P2Y1, P2Y12 and P2Y13 receptors) or ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
92 Adenosine is crucial for deep brain stimulationmediated attenuation of tremor
 

Summary:  , resulting in accumulation of its catabolic product, adenosine. Adenosine A1 receptor activation depresses... infusion of A1 receptor agonists directly reduces tremor, whereas adenosine A1 receptor­null mice show... notion that caffeine, a nonselective ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
93 Purinergic signalling in autonomic Alexander V. Gourine1
 

Summary:  -receptor-mediated) and facilitatory (A2A-receptors-mediated) presynaptic actions of adenosine... , adenosine evokes slow EPSP-like excitatory responses mediated via A2A receptors [49]. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
94 Nature Macmillan Publishers Ltd 1997 arterial blood sampling (0.5 ml samples) and
 

Summary:  , observed after blockade of peripheral adenosine receptors, and was not specific for caffeine. This find... reduction after antagonist with- drawal, suggests receptor-mediated regula- tion of the plasma adenosine... in the world1 , with actions mediated primarily by adenosine ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
95 Immunobiology 209 (2005) 661668 Impairment of the splenic immune system in P2X2/P2X3 knockout mice
 

Summary:  (Burnstock, 1990). Activation of a1-, a2- and b-adrenoceptors on immune cells regulate immunomodulatory... . The isolated spleen of the rat contracts in the presence of adenosine and several adenosine receptor agonists... and KO animals failed to contract to adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
96 Postnatal development of P2 receptors in the murine gastrointestinal tract
 

Summary:  further subdivided into A1, A2A, A2B and A3. P2 receptors have been divided into two families (Ab... ¼ adenosine, suggesting P2Y1 receptors. This was supported by the sensitivity of responses to 2-Me... equipotent suggesting a P2Y2 and/or P2Y4 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
97 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Predicted structures of agonist and
 

Summary:  Alignments of the four adenosine receptor (AR) subtypes, A1, A2A, A2B, and A3 from the PredicTM method... of Human Adenosine A2A and A3 Receptors from the CombiHelix Analysis of the ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
98 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... , 1976a], and a basis for distinguishing P1 (adenosine) from P2 (ATP/ADP) receptors was pro- #12... :246­254. Vainio M, Törnquist K. 2000. The ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
99 Colocalization and Regulated Physical Association of Presynaptic Serotonin Transporters with A3 Adenosine
 

Summary:  Adenosine ReceptorsS Chong-Bin Zhu, Kathryn M. Lindler, Nicholas G. Campbell, James S. Sutcliffe, William A... ; accepted June 24, 2011 ABSTRACT Activation of A3 adenosine receptors (A3ARs) rapidly enhances the activity... -activated protein kinase; A3AR, A3 subtype adenosine ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine

 
100 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  --the human 2 adrenergic receptor (2AR), the avian 1AR and the human A2A adenosine receptor--as well... bound to the antagonist cyanopindolol24 ; the human A2A adenosine receptor bound to the antagonist ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine


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