| Sample search results for: a2 adenosine receptors |
| 1 | Adenosine-Mediated Presynaptic Modulation of Glutamatergic Transmission in the Laterodorsal Tegmentum | ||
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Summary: , at least in part, by the activation of additional adenosine receptor subtypes. Are adenosine A2 receptors... of adenosine (Fig. 5B) might have resulted from the coactivation of A2 ... |
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Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University |
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Collection: Biology and Medicine |
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| 2 | 0022.3565/87/2423-0882S00.00/0 THE JOURNALor PHARMACOLOGYAND EXP!JUNENTALTHERAPEIITICS | ||
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Summary: . A2 adenosine receptors. Blockade of the negative chronotropic effect of bolus Lv. injections of 2... as an index of activity at A2 receptors. Inaddition, blockade of the potentiating effect of adenosine... the bradycardiac ... |
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Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 3 | Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle | ||
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Summary: . Prior studies have demonstrated that adenosine A2B receptors regulate production... laboratory and others indicate that adenosine A2A receptors play an important role... ... |
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Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University |
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Collection: Biology and Medicine |
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| 4 | doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol | ||
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Summary: surface adenosine receptors (12). Four subtypes of adenosine receptors have been defined, A1, A2a, A2b... of this process are known. Western blot analysis established that all four aden- osine receptors ... |
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Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh |
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Collection: Biology and Medicine |
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| 5 | Behavioral/Systems/Cognitive A Circadian Clock and Light/Dark Adaptation Differentially | ||
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Summary: by the presence of retinal adenosine metabolic pathway enzymes and receptor subtypes A1 and A2A and by the effects... ) Adenosine in vertebrate retina: localization, receptor characterization, and function. Cell Mol Neurobiol 11... Adenosine in ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 6 | In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to | ||
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Summary: activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... and 4 the yeast system is exploited to study inverse agonism of the human adenosine A2B ... |
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Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden |
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Collection: Physics |
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| 7 | Biochemistry Insect Biochemistry and Molecular Biology 35 (2005) 381389 | ||
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Summary: -[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J. 14, 20652074. Heming, B... insects or Metazoa. The expression of most of the Drosophila adenosine deaminases (ADGF-A2,-B,-C and E... .J., Christoffel, ... |
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Source: urovec, Michal - Department of Physiology, University of South Bohemia |
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Collection: Biology and Medicine |
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| 8 | Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins | ||
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Summary: July 15, 2004; doi:10.1152/ ajpgi.00164.2004.--Adenosine, acting through the A2b receptor, in- duces... of the A2b receptor may be required for its signaling. vesicle; adenosine; vesicle-associated membrane... to be involved ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 9 | 0022.3565/86/2362.0350S02.oo/0 THE JOURN"L or PH..R COLO<:Y..,..D EXPF.H'''ENT''L THER"PEl'TIC~ | ||
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Summary: that an adenosine receptor resembling the A2 subtype mediates the potentiation by adenosine of sympathomimetic... .C.: Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular ... |
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Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 10 | The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor | ||
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Summary: endogenous P2Y receptors in addition to the P1 adenosine receptors A2A and A2B, which might complicate... are influenced by a physical interaction between GPR80/GPR99 and endogenous P2Y or A2B ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 11 | For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133 | ||
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Summary: (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... principally P2Y1, P2Y2 and A2 receptors, which mediate vasorelax- ation to ADP, UTP/ATPand ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 12 | ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and | ||
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Summary: were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being investigated... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 13 | Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury | ||
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Summary: demonstrated a potent cytoprotective role of adenosine A1, A2A, and A3 receptors in ischemia and reperfusion... mediates protection is not the same. The adenosine A3 receptor, but not the A1 or A2A ... |
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Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa |
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Collection: Biology and Medicine |
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| 14 | The birth and postnatal development of purinergic signalling G. Burnstock,1 | ||
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Summary: through adenosine receptors. This suggestion was based largely on the observation that adenosine and its... that several factors including adenosine receptors, NO and KATP channels contribute, and may act... vesical parasympathetic ganglia, purines suppressed synaptic transmission ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 15 | Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson | ||
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Summary: Signaling The Periphery Adenosine A1, A2A, A2B, and A3 receptors (ARs) are all present at peripheral sites... signaling in inflammatory states. Adenosine A2B and A3 receptors have not ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 16 | Biochemistry Insect Biochemistry and Molecular Biology 37 (2007) 318329 | ||
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Summary: for adenosine and adenosine receptor agonist binding in point mutation experiments for the human A1, A2A and A3... 50 values for adenosine-induced cAMP response of the human A1, A2A, ... |
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Source: urovec, Michal - Department of Physiology, University of South Bohemia |
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Collection: Biology and Medicine |
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| 17 | ADENOSINE, PROLONGED WAKEFULNESS, AND A1-ACTIVATED NF-UB DNA BINDING IN THE BASAL FOREBRAIN OF THE RAT | ||
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Summary: to adenosine. Other investigators have shown that infusion of the A2A receptor agonist 4-[2-[[6-amino-9-(N... deprivation on adenosine A1 and A2a receptor binding and mRNA in rat brain. World Federation Sleep Research... ... |
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Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University |
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Collection: Biology and Medicine |
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| 18 | Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion | ||
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Summary: roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus... receptors to decrease neurotransmitter release or A2A receptors to potentiate neuro- transmitter release... release are ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 19 | Purinergic Signaling and Vascular Cell Proliferation and Death Geoffrey Burnstock | ||
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Summary: established.1,2 P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B, and A3) have been identified... . Adenosine inhibits vascular smooth muscle cell prolifera- tion by A2 ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 20 | The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle | ||
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Summary: conditions, while adenosine A2 receptor-mediated responses were not sensitive to temperature changes... for responses mediated via A1-receptors but not A2-receptors. Br. J. Pharmacol. 84, 407415. Burnstock, G., 1996... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 21 | Purinergic regulation of vascular tone and remodelling | ||
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Summary: ; Burnstock, 2007a). P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B 63 Autonomic & Autacoid... of ATP acts on P1 (A2) receptors to inhibit cell proliferation [via elevation of cyclic ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 22 | Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal & | ||
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Summary: to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... , induced [Ca2+ ]i elevation via activation of A2A receptors [77]. In cultured mouse astrocytes ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 23 | J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0 | ||
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Summary: cells were stably transfected with a double hemagglutinin-tagged (HA-tagged) dog adenosine A2A receptor... for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and ... |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 24 | Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum | ||
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Summary: Title Page Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co... ; Accepted: Aug 12, 2011 #12;Abstract The adenosine A2A receptor (A2AR) is a ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 25 | This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the | ||
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Summary: Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... are ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 26 | This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the | ||
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Summary: Encyclopedia of Neuroscience (2009), vol. 1, pp. 105-113 Author's personal copy #12;A2A (P1) receptors... .deaminase Inosine Smooth muscle receptors P2 Purinoceptor 5 -nucleo- ATP resynthesis Adenosine Adenosine uptake... vasoconstriction (+) via P2X ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 27 | *National Institute of Child Health and Human | ||
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Summary: - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... roles are not fully known. A1 , A2A , A2B and A3 adenosine ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 28 | RESEARCH PAPER Role of ATP and related purines in inhibitory | ||
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Summary: through muscle A2A receptors after breakdown to adenosine, and P2Y1 receptors after breakdown to ADP... ; adenosine; P2Y1- and A2A-receptors; pig urinary bladder neck Abbreviations: ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 29 | No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system after chronic A1 receptor | ||
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Summary: Chapter 7 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system... these lines, there are data suggesting cross-talk between the adenosine and serotonin receptor systems... of the adenosine A1 receptor agonist N6 ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 30 | Samenvatting In dit proefschrift wordt een gecombineerde aanpak besproken om aan de hand van de | ||
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Summary: adenosine A2B receptor de constitutieve activiteit van aan G-eiwitten gekoppelde receptoren (GPCRs) te... wordt dit gistsysteem gebruikt om invers agonisme van de adenosine A2B receptor van de mens te... . In hoofdstuk 5 is de ... |
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Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden |
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Collection: Physics |
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| 31 | The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine | ||
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Summary: , adenosine (ADO) also appears to act on sensory terminals, probably directly through P1(A2 ) receptors... disorders, highlighting specific purinergic receptor subtypes, most notably A2A , P2X4 and P2X7 ,that might... in rodents, which is ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 32 | The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 11 2417-2427 | ||
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Summary: ). The immunoregulatory attributes of adenosine are mediated via four transmembrane adenosine receptors: A1, A2A, A2B... and neutrophils express all four adenosine receptors, whereas B cells harbor only ... |
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Source: Chicago, University of - Department of Microbiology |
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Collection: Biology and Medicine |
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| 33 | Structure based prediction of subtype-selectivity for adenosine receptor antagonists | ||
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Summary: into the structural basis of ligand subtype selectivity within the family of adenosine receptors (AR: A1, A2A, A2B... protein-coupled receptor; AR, adenosine receptor; ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 34 | Endothelium-Derived Vasoconstriction by Purines and Pyrimidines | ||
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Summary: , prostaglandin H2, thromboxane A2, and superoxide anions.6,7 To¨lle et al1 present compelling evidence... by To¨lle et al1 claims to show for the first time that adenosine 5 -tetraphosphate (AP4) is released... , that AP4 is the most potent mediator of vascular smooth muscle constric- tion via P2X1 ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 35 | ATP signalling in epilepsy Ashwin Kumaria & Christos M. Tolias & | ||
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Summary: effects [11, 12]. On the other hand, Zeraati et al. [13] elegantly showed that A2A receptors in the CA1... . Epilepsia 46:166173 13. Zeraati M, Mirnajafi-Zadeh J, Fathollahi Y et al (2006) Adenosine A1 and A2A... and is believed to inhibit distant synapses by acting ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 36 | This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research | ||
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Summary: t Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests... receptor function [10,32]. Adenosine type A1 and A2A receptors on glutamatergic terminals play a ... |
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Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University |
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Collection: Biology and Medicine |
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| 37 | This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research | ||
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Summary: ATP Adenosine P2 receptor P1 receptor The inhibitory effects of ATP and adenosine on the nerve... 2 receptor antagonist, PPADS (10 M), did not significantly change the inhibitory effect of adenosine... was antagonized by 8-SPT and not affected by PPADS, which ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 38 | Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd. | ||
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Summary: to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors... 1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 39 | Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and | ||
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Summary: this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... with the excitatory actions of ATP on nerve cells. Adenosine (P1) receptor activation can inhibit ATP release. ATP... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 40 | Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells | ||
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Summary: , and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest... growth factor receptor KDR/Flk gene expression through adenosine A2 recep- tors in retinal capillary... , Nakashima ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 41 | Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm | ||
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Summary: subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... adenosine. This is suggestive of P2Y1-mediated relaxation and perhaps a further P2Y receptor subtype... classification of ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 42 | PURINERGIC SIGNALING IN ATHEROSCLEROSIS AND RESTENOSIS Geoffrey Burnstock, Autonomic Neuroscience Centre, Royal Free and University | ||
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Summary: in angiogenesis [26]. Endothelial cell proliferation is mediated by A2A and A2B receptors and some... of the mitogenic effects are mediated via the modulation of VEGF signaling. There is evidence that A2B receptors... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 43 | Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance | ||
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Summary: between adenosine and dopa- mine receptors, the A1R/mGluR1 and A2AR/mGluR5 in- teractions facilitate... . (2003) Adenosine A2A-dopamine D2 receptor- receptor heteromerization: qualitative and ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 44 | Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation | ||
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Summary: receptors. Adenosine acting through A2 receptors inhibits smooth muscle proliferation but stimulates... ,2325 and it is currently recognised that there are four subtypes of P1 receptors (A1, A2A, ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 45 | Double-Stranded RNA Adenosine Deaminases ADAR1 and ADAR2 Have Overlapping Specificities | ||
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Summary: . Calculations that include all adenosines give a value of 28% deamination for both enzymes. hA2, hADAR2; xA1, x... I site immediately downstream of the TOP2 gene has been replaced with a unique XhoI site. pSc[hA2a-H6... in yeast (18). BCY123 colonies containing ... |
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Source: Bass, Brenda L. - Departments of Biochemistry & Human Genetics, University of Utah |
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Collection: Biology and Medicine |
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| 46 | TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6 | ||
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Summary: , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... A2 receptors; however, it might also act (broken arrow) to potentiate P2X3 or ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 47 | Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India | ||
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Summary: the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... Y metabotropic receptor subtypes, as well as four subtypes of P1 receptors sensitive to adenosine... while ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 48 | Genetics of caffeine consumption and responses to caffeine Amy Yang & Abraham A. Palmer & Harriet de Wit | ||
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Summary: and A2A receptors (Daly et al. 1983). Adenosine receptors are G-protein-coupled receptors locat- ed... and humans have implicated polymorphisms in adenosine A1 and A2A receptors in ... |
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Source: Das, Soma - Department of Human Genetics, University of Chicago; Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago |
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Collection: Biology and Medicine |
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| 49 | pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799 | ||
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Summary: recently of human A2A adenosine receptor35 (A2AAR) in com- plex with antagonist 1 (ZM24138536 ), open... , adenosine receptor; A2AAR, subtype ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 50 | Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK | ||
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Summary: receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... . Blockade of A2A (P1) receptors antagonises parkinsonian tremor in the rat tacrine model by actions... on specific ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 51 | P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a | ||
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Summary: selectivity of P2X receptors, and why adenosine, polyphosphate or other nucleotides such as GTP and UTP... P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of receptors |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 52 | Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd. | ||
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Summary: , two subtypes of the P1 (adenosine) receptor were recognised [5,6], but it was not until 1985... activate phospholipases A2, C and D, MEP/MAP kinase, Rho-dependent kinase and tyrosine kinase, as well... Theuse of theophylline, an adenosine receptor antagonist, as an ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 53 | Conserved waters mediate structural and functional activation of family A (rhodopsin-like) | ||
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Summary: , engineered A2A-adenosine, 1- and 2-adrenergic receptors, permits comparative analysis of features common... (omitting the T4 lysozyme amino acid sequence present in mutant 2-adrenergic receptor and A2A-adenosine... identity, ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 54 | Physiology and Pathophysiology of Purinergic Neurotransmission | ||
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Summary: receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... /ADP, respectively), was proposed (246). At about the same time, two subtypes of the P1 (adenosine) receptor were... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 55 | Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock | ||
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Summary: , Le Moine C, Fisone G, et al. (1999): Distribution, biochemistry and function of striatal adenosine A2... so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... :85-108 [MEDLINE] Ferre S, Fredholm ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 56 | A Role for Adenosine Deaminase in Drosophila Larval Development | ||
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Summary: functions by binding to G protein-coupled adenosine receptors (A1, A2a, A2b, and A3 in mammals) that can... the adenosine receptor (AdoR), but fat body disintegration, which is promoted by action of the hemocytes, seems... ... |
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Source: Gibson, Matt - Stowers Institute for Medical Research; urovec, Michal - Department of Physiology, University of South Bohemia |
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Collection: Biology and Medicine |
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| 57 | Purine and pyrimidine receptors G. Burnstock | ||
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Summary: , hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674 678. 28 Sun... by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 58 | Purine and pyrimidine receptors G. Burnstock | ||
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Summary: , hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388, 674 678. 28 Sun... , complementary DNAs (cDNAs) encoding two different P1 receptor subtypes (A1 and A2) were isolated [20], and... , shortly after, the ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 59 | REVIEW ARTICLE The journey to establish purinergic signalling in the gut | ||
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Summary: of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system. J Comp Neurol 2001; 439: 46... 64. 42 Gao N, Hu HZ, Liu S, Gao C, Xia Y, Wood JD. Stimulation of adenosine A1 and A2A ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 60 | Evolutionary origins of the purinergic signalling system G. Burnstock1 | ||
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Summary: the larvae of the blowfly Calliphora vicina (Magazanik & Fedorova 2003). An A2 adenosine receptor subtype... connected by commisures. Early studies showed adenosine to have a modulatory action via A1 and A2 receptors... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 61 | Purinergic signalling *Geoffrey Burnstock | ||
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Summary: . Adenosine, via A2A receptors, has a protective effect in a rat model of Parkinson's disease, perhaps... /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 62 | Specificity of RNARNA helix recognition Daniel J. Battle* and Jennifer A. Doudna | ||
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Summary: unpaired adenosine residues dock into the minor groove of a receptor helix. This A-minor motif, potentially... of the adenosine 2 -OH relative to the 2 -OH groups of the receptor base pair, with the first position... of the receptor base pair defined as the residue closest to the 2 -OH ... |
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Source: Doudna, Jennifer A. - Department of Molecular and Cell Biology, University of California at Berkeley |
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Collection: Biology and Medicine |
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| 63 | Purinergic signalling in the nervous system: an overview | ||
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Summary: adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... /or astrocytes that release adenosine directly [18]. Receptors for purines and pyrimidines Separate membrane... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 64 | Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila | ||
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Summary: , encoding ADGF-A and ADGF-B, as well as ADGF-A2, previously re- ported as male-specific insect... -derived growth factor, or MSI (12). The ADGF-A2 gene is included within the 5 intron of the ADGF-A gene. Two... in the adult only in the male abdomen, possibly reflecting testis-specific expression as described ... |
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Source: urovec, Michal - Department of Physiology, University of South Bohemia |
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Collection: Biology and Medicine |
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| 65 | REVIEW ARTICLE Chemokine receptors and other G protein-coupled receptors | ||
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Summary: of invertebrate rhodopsin, b1-adrenergic and b2-adrenergic receptors and the A2A-adenosine receptor have been... -adrenergic and b2-adrenergic receptors, and most recently, the structure of the A2A ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 66 | INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM | ||
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Summary: for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... ., 2001. Activation of protein kinase A and atypical protein kinase C by A2A adenosine ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 67 | J Physiol 589.2 (2011) pp 283295 283 The dynamics of single spike-evoked adenosine release | ||
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Summary: , the modulation of adenosine release by specific G-protein coupled receptor agonists strongly suggests... mediated by glutamate receptor activation In control conditions (absence of 4-AP), adenosine release... of the adenosine release stems from AMPA receptor ... |
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Source: Richardson, Magnus - Systems Biology Centre, University of Warwick |
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Collection: Biology and Medicine |
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| 68 | Ecto-5V-nucleotidase activity in brain membranes of zebrafish (Danio rerio) | ||
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Summary: ) 203207206 #12;A2A adenosine receptors (Magalha~es-Cardoso et al., 2003). In summary, considering... modifies cell functioning by operating G-protein-coupled receptors (A1, A2A, A2B, A3), which can ... |
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Source: Eizirik, Eduardo - Centro de Biologia Genômica e Molecular da Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul |
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Collection: Environmental Sciences and Ecology |
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| 69 | Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate | ||
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Summary: protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate in urological... purinergic ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 70 | Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss | ||
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Summary: .F., Schwarzschild, M.A., Fredholm, B.B., Urade, Y., and Hayaishi, O. (2005). Adenosine A2A, but not A1, receptors... ), or of caffeine (Figures 3G and S11), which is known to act via A2A receptors in this behavior (Huang et al., 2005... that by ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 71 | INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE Olfactory Receptor Interactions | ||
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Summary: receptors, and A2A adenosine receptor. These four receptors were further- more found... INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE Olfactory Receptor Interactions with Other Receptors... Olfactory ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 72 | JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004 | ||
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Summary: ; PKA, protein kinase A; PKC, protein kinase C; PLA2, phospholipase A2; PLC, phospholipase C; PLD... JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004 Dopamine Receptor... The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has ... |
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Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University |
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Collection: Biology and Medicine |
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| 73 | lagC-Null and gbf-Null Cells Define Key Steps in the Morphogenesis of Dictyostelium Mounds | ||
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Summary: or counterclockwise (Figs. 2a2c) about a center point (61/66 mounds). Cells normally moved per- pendicular... of adenosine to the class of receptors (Kd 350 m) noncompetitively inhibits cAMP binding to cAMP receptors... be overcome by the addition of adenosine, ... |
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Source: Firtel, Richard A. - Division of Biological Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 74 | This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research | ||
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Summary: (hb2AR) (Cherezov et al., 2007) and adenosine A2A receptor (hAA2AR) (Jaakola et al., 2008)]. Moreover... . In addition, we predicted structures for the human A1, A2B, and A3 adenosine receptors (ARs) and used... /mol) of ... |
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Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology |
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Collection: Materials Science |
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| 75 | The Uroepithelial-associated sensory web , E Balestreire1 | ||
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Summary: family ErbB13 receptors,17 A1, A2a, A2b, and A3 adenosine receptors,18 a- and b-adrenergic receptors,19... , we observe that adenosine, most likely acting through A1 and ... |
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Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh |
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Collection: Biology and Medicine |
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| 76 | Cellular/Molecular Calcium Increases in Retinal Glial Cells Evoked by Light- | ||
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Summary: that adenosine potentiation of Mu¨ller cell Ca2 responses is mediated primarily by A2B receptors, in agreement... -induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes. Br J Pharmacol ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 77 | Prediction of the 3D structure of rat MrgA G protein-coupled receptor and identification of its binding site | ||
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Summary: and hA2AA) receptors and human P2Y1 purinergic (hP2Y1) receptor. These receptors all bind adenosine... compare the binding site of adenine to rat MrgA with the binding site of human A1 and A2A adenosine ... |
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Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology |
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Collection: Materials Science |
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| 78 | Historical review: ATP as a neurotransmitter | ||
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Summary: neuroprotective agents in the cortex, hippocampus and cerebellum. Blockade of A2A (P1) receptors antagonises... to adenosine by ectoenzymes, so that some of the actions of ATP were directly on P2 receptors, whereas others... were due to the indirect action of ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 79 | Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety | ||
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Summary: by activating group I P2X receptors. Diadenosine polyphosphates (ApnAs) and adenosine polyphospho guanosines... 1.30 1.061.67 0.8 0.1 Ap5A 2.89 2.403.47 1.0 0.1 Ap5G 2.76 2.093.66 1.0 0.1 Ap6A 4.32 3.575.23 1... hexaphosphate (AP6A) via A1-adenosine ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 80 | P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock | ||
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Summary: phase of the reactive hyperaemia as has been shown by infusion of adenosine deaminase or a selective A2A... phase hyperaemia mediated via A2A receptors on smooth muscle cells. Red blood cells as regulators... hyperaemia via endothelial P2Y1 ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 81 | GPCR agonist binding revealed by modeling and crystallography | ||
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Summary: with recently determined agonist-bound structures of b-ad- renergic and adenosine A2A receptors reveals high... agonist binding predictions Adenosine A2A receptor (AA2AR) modeling studies [18,29] provide another... . Agonist ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 82 | J Physiol 588.1 (2010) pp 9399 93 SYMPOSIUM REVIEW | ||
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Summary: adenosine A2A receptors are essential for inducing LTP of NMDA-EPSCs (Rebola et al. 2008). A2A receptors may... of mossy fibres lead to the activation of NMDA, mGluR5 and adenosine A2A ... |
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Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 83 | Pathophysiology and Therapeutic Potential of Purinergic Signaling | ||
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Summary: ). The therapeutic poten- tial of adenosine A2A receptor antagonists in Parkinson's 64 BURNSTOCK #12;disease is being... receptor activation that triggers adenosine release, leading to activation of P1 (A2A) ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London; Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London |
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Collection: Biology and Medicine ; Geosciences |
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| 84 | ARTICLE IN PRESS Purinergic P2 receptors as targets for novel analgesics | ||
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Summary: inhibitor of transmission via P1(A2) purinoceptors. P2X3 receptors on the central projections of primary... directly via P1(A2) purinoceptors; however, it also acts synergistically (broken red line) to potentiate P2... broken down by ectoenzymes to ADP (to act on P2Y1, P2Y12, and P2Y13 ... |
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Source: Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London |
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Collection: Geosciences |
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| 85 | Purinergic P2 receptors as targets for novel analgesics Geoffrey Burnstock * | ||
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Summary: ATP, adenosine (AD) also appears to act on sensory terminals, probably directly via P1(A2... as heteromultimers, and after breakdown to adenosine, it acts as a prejunctional inhibitor of transmission via P1(A2... by ectoenzymes to ADP (to act on P2Y1, P2Y12, and ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 86 | ORIGINAL ARTICLE An in vivo model of melanoma: treatment with ATP | ||
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Summary: S, Sitkovsky M (2006) A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad... , Dwyer K, Robson SC, Ohta A (2008) Adenosine A2A receptor antagonists: blockade of adenosinergic effects... ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 87 | Supporting Information Angel et al. 10.1073/pnas.0903545106 | ||
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Summary: ), mutant 2-adrenergic receptor (2), squid rhodopsin (3), bovine rhodopsin (4), and mutant A2A-adenosine... of G-coupled protein receptors (GPCRs). Amino acid sequences from mutant 1-adrenergic receptor (1... receptor (5) were aligned with ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 88 | doi:10.1152/physiolgenomics.00068.2005 23:89-102, 2005. First published Jul 26, 2005;Physiol. Genomics | ||
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Summary: inactivation of adenosine A2A receptor reveals an Egr-2-mediated transcriptional regulatory network... Weng, and Jiang-Fan Chen. Genetic and pharmacological inactivation of adenosine A2A receptor reveals... 102, 2005. First ... |
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Source: Weng, Zhiping - Center for Advanced Genomic Technology, Boston University |
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Collection: Biotechnology |
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| 89 | Editorial Manager(tm) for Nuclear Medicine Communications Manuscript Draft | ||
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Summary: there are still controversies on how adenosine receptors (A1, A2A, A2B, and A3) mediate the cardioprotection... and relates with the activation of adenosine receptors in rat hearts. FastSPECT GLA imaging is not only useful... ... |
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|
Source: Arizona, University of - Center for Gamma-Ray Imaging |
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Collection: Engineering ; Biology and Medicine |
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| 90 | Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins, | ||
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Summary: ., 2004), and strokes and cere- bral hypoperfusion (altered adenosine A2A receptor function... Receptor versus Rhodopsin. Like the 2- adrenergic receptor, the human A2A adenosine ... |
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Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University |
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Collection: Biology and Medicine |
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| 91 | Purines and Sensory Nerves Geoffrey Burnstock | ||
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Summary: of receptors for purines and pyrimidines are available, including four subtypes of P1 (adenosine), seven... and internalization of P2Y receptors in DRG neurons (Wang et al. 2006). Adenosine 50 -O-(3-thiotriphosphate) enhances... act on P2Y1, P2Y12 and P2Y13 receptors) or ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 92 | Adenosine is crucial for deep brain stimulationmediated attenuation of tremor | ||
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Summary: , resulting in accumulation of its catabolic product, adenosine. Adenosine A1 receptor activation depresses... infusion of A1 receptor agonists directly reduces tremor, whereas adenosine A1 receptornull mice show... notion that caffeine, a nonselective ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 93 | Purinergic signalling in autonomic Alexander V. Gourine1 | ||
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Summary: -receptor-mediated) and facilitatory (A2A-receptors-mediated) presynaptic actions of adenosine... , adenosine evokes slow EPSP-like excitatory responses mediated via A2A receptors [49]. ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 94 | Nature Macmillan Publishers Ltd 1997 arterial blood sampling (0.5 ml samples) and | ||
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Summary: , observed after blockade of peripheral adenosine receptors, and was not specific for caffeine. This find... reduction after antagonist with- drawal, suggests receptor-mediated regula- tion of the plasma adenosine... in the world1 , with actions mediated primarily by adenosine ... |
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Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 95 | Immunobiology 209 (2005) 661668 Impairment of the splenic immune system in P2X2/P2X3 knockout mice | ||
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Summary: (Burnstock, 1990). Activation of a1-, a2- and b-adrenoceptors on immune cells regulate immunomodulatory... . The isolated spleen of the rat contracts in the presence of adenosine and several adenosine receptor agonists... and KO animals failed to contract to adenosine ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 96 | Postnatal development of P2 receptors in the murine gastrointestinal tract | ||
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Summary: further subdivided into A1, A2A, A2B and A3. P2 receptors have been divided into two families (Ab... ¼ adenosine, suggesting P2Y1 receptors. This was supported by the sensitivity of responses to 2-Me... equipotent suggesting a P2Y2 and/or P2Y4 ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 97 | proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Predicted structures of agonist and | ||
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Summary: Alignments of the four adenosine receptor (AR) subtypes, A1, A2A, A2B, and A3 from the PredicTM method... of Human Adenosine A2A and A3 Receptors from the CombiHelix Analysis of the ... |
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Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology |
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Collection: Materials Science |
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| 98 | 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001) | ||
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Summary: were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... , 1976a], and a basis for distinguishing P1 (adenosine) from P2 (ATP/ADP) receptors was pro- #12... :246254. Vainio M, Törnquist K. 2000. The ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 99 | Colocalization and Regulated Physical Association of Presynaptic Serotonin Transporters with A3 Adenosine | ||
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Summary: Adenosine ReceptorsS Chong-Bin Zhu, Kathryn M. Lindler, Nicholas G. Campbell, James S. Sutcliffe, William A... ; accepted June 24, 2011 ABSTRACT Activation of A3 adenosine receptors (A3ARs) rapidly enhances the activity... -activated protein kinase; A3AR, A3 subtype adenosine ... |
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Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University |
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Collection: Biology and Medicine |
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| 100 | The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have | ||
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Summary: --the human 2 adrenergic receptor (2AR), the avian 1AR and the human A2A adenosine receptor--as well... bound to the antagonist cyanopindolol24 ; the human A2A adenosine receptor bound to the antagonist ... |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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