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Sample search results for: abcb1 drug transporters

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1 Reduced intracellular accumulation of calcein by overexpression of fluorescent protein fusions of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos.
 

Summary:  of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos. Amro Hamdoun1 1... fluorescent protein (FP) fusions of the candidate sea urchin P-gp transporter Sp-ABCB1a, and then to determine... of the up-regulated activities is ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
2 Clin Pharmacol Ther . Author manuscript Donor P-gp polymorphisms strongly influence renal function and graft
 

Summary:  3A and the efflux transporter P-glycoprotein (P-gp; ), bothABCB1 abundantly expressed in the kidney... of the efflux transporter P-glycoprotein (P-gp; gene) extruding xenobiotics1 ABCB1 from the cell ( ). The most... independently of its effect on the ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
3 Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients with long term follow-up.
 

Summary:  transporter P- glycoprotein (P-gp; ABCB1), both abundantly expressed in the kidney. We retrospectively... transplantation (1). CsA is a substrate of the efflux transporter P-glycoprotein (P-gp; ABCB1 gene) extruding... investigated the role of polymorphisms in ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
4 Response to "PREDICTABLE DIFFICULTY OR DIFFICULTY TO PREDICT" by Tams Arnyi, Krisztina Fulop, Orsolya Symmons, Viola Pomozi, and Andrs Vradi
 

Summary:  classification as "disease-associated" is not justified. Mutant V1251I of ABCB1 showed decreased transport... -altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay. PLo... arguing against an unequivocal ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
5 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  -brain barrier, the three most prevalent ABC transporters are P-glycoprotein (P-gp) (encoded by ABCB1), multidrug... transporters that block the passage of drugs across the blood- brain barrier. The three most prevalent ATP... in cytotoxicity of drugs effluxed at each ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
6 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  -brain barrier, the three most prevalent ABC transporters are P-glycoprotein (P-gp) (encoded by ABCB1), multidrug... transporters that block the passage of drugs across the blood- brain barrier. The three most prevalent ATP... in cytotoxicity of drugs effluxed at each ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
7 A Resource to Acquire and Summarize Pharmacogenetics Knowledge in the Literature Daniel L. Rubin, Michelle Carrillo, Mark Woon, John Conroy, Teri E. Klein, and Russ B. Altman
 

Summary:  , then all the drugs and diseases associated with ABCB1 are shown (Figure 2). Clicking on the "Details... are shown, allowing the user to quickly determine how the various drugs and diseases are related to ABCB1... . This display shows that digoxin and prednisone ...

  

Source: Rubin, Daniel L. - Department of Radiology, Stanford University

 

Collection: Biology and Medicine

 
8 Precision-cut slices as a tool to study induction of drug metabolism
 

Summary:  , CYP3A4, 17- HSD) and phase II metabolism (UGT1A6) and phase III transport (MDR1/ABCB1). In addition... Predictive in vitro methods to investigate induction of drug metabolizing enzymes and transporters... (2-fold), UGT1A6 (2.2 and 32-fold) and ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
9 PharmGKB Submission Update: IV. PMT Submissions of Genetic Variations in ATP-
 

Summary:  and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Phar- macogenetics 13... into these restricted sites. The overexpression of some ABC transporters is associated with drug resistance in tumors... or blood for elimination or distribution. Summary of ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
10 Published on Web Date: October 21, 2010 r 2010 American Chemical Society 82 DOI: 10.1021/cn100078a |ACS Chem. Neurosci. (2011), 2, 8289
 

Summary:  transporter ABCB1. Recent positron emis- sion tomographic brain imaging studies using [11 C]- tariquidar... reaction to elucidate the mechanism of transport by P-gly- coprotein (ABCB1). J. Biol. Chem. 281, 26501... to measure ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
11 Function of prokaryotic and eukaryotic ABC proteins in lipid transport Antje Pohla,b
 

Summary:  and Gottesmann [1] pointed out that ABCB1 (MDR1 Pgp) behaved like a bflippaseQ which would be able to transport... of structurally unrelated drugs. ABCB1 is involved in other phenomena as well, in which, interestingly, lipid... to the outward ...

  

Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques

 

Collection: Chemistry ; Biology and Medicine

 
12 Applied Mathematics Letters 24 (2011) 12511256 Contents lists available at ScienceDirect
 

Summary:  responsible for CPT11 efflux and stands for the cumulative activity of ABCB1, ABCC1 and ABCC2. Transporters... -modulated ABC transporter induction CPT11 exposure may enhance the expression of ABCB1 and ABCG2 both... Drug-driven ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine

 
13 Introduction to multidrug transporters, cellular resistance and lantibiotic production in Lactococcus lactis
 

Summary:  transporter ABCB1 (P-glycoprotein or MDR1) is a full- transporter in which a single polypeptide encompasses... transporters and when aligned with both the N- and C-terminal halves of the human ABCB1, approximately one... define the function of ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
14 J Biopharm Stat. Author manuscript Comparison of model-based tests and selection strategies to detect
 

Summary:  therapeutic drug monitoring in anti-retroviral therapy. Since the ABCB1 genetic polymorphism was found to have... the subject of much attention, for example the ABCB1 gene coding for the PLicinio and Wong, 2002 glycoprotein... , Yamaguchi and colleagues demonstrated the impact of ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
15 Model-based tests for pharmacogenetic analyses Comparison of model-based tests and selection strategies to detect genetic
 

Summary:  of early therapeutic drug monitoring in anti-retroviral therapy. Since the ABCB1 genetic polymorphism... (Licinio and Wong, 2002). Some genes have already been the subject of much attention, for example the ABCB1... recently, Yamaguchi and colleagues demonstrated the impact of ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
16 Ecole Polytechnique Thse de doctorat
 

Summary:  .3 ABCA12 2q34 ABCA/ABC1 ABCA13 7p12.3 ABCB1 MDR1, P-gp, ABC20, GP170, PGY1 7q21.1 ABCB2 TAP1, PSF1, RING4... 2 NH2 COOH a) ABCC7/CFTR ABCB1/P-gP ABCC1/MRP1 ABCB2-3/TAP R b) R TMD NBD Domaine régulateur pastel... ), troubles respiratoires, infectieux ou alimentaires ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
17 Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus)
 

Summary:  of transporter activity. In addition, we directly measured the levels of transcripts of SpABCC1 and SpABCB1... efflux. SpABCB1 encodes an efflux transporter similar to p- gp, an extensively studied xenobiotic... of real-time q-pcr analysis of mrp (SpABCC1) and p-gp ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
18 European Journal of Clinical Pharmacology manuscript No. (will be inserted by the editor)
 

Summary:  the impact on indinavir pharmacokinetics of ABCB1 polymorphisms, a gene inserm-00384935,version1-17May2009... shown that the ABCB1 C3435T genotype affects the absorption constant of indi- navir whereas Verstuyft et... Kit (Qiagen, Courtaboeuf, France). ABCB1 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
19 Antimicrob Agents Chemother . Author manuscript Population pharmacokinetic-pharmacogenetic study of nevirapine in
 

Summary:  of variability focusing on the , and ( genes.CYP2B6 CYP3A5 ABCB1 MDR1) 170 Cambodian HIV-infected patients were... >T CYP2B6 1459C>T ABCB1 represent 42.4 , 9.2 , 0 and 18 of the population, respectively.3435C... ( ). and ( , which endcodes for P-glycoprotein) are known to be highly polymorphic (1 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
20 Functional hot spots in human ATP-binding cassette transporter
 

Summary:  . For example, transporters such as ABCB1 are expressed in many different cell types,32 whereas ABCA4... transporters An additional three variants in ABCB1 (P-glycopro- tein) were experimentally characterized... -glycoprotein ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology


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21 Epilepsia, **(*):110, 2007 Blackwell Publishing, Inc.
 

Summary:  of multidrug resis- tance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. New England... transporter ABCB1 (P-glycoprotein) nucleotide binding domain 2, residues 1028-1271. The Walker A motif... : Background: Multidrug ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
22 Comparison of [11 C]-(R)-PK 11195 and [11
 

Summary:  pair selectively overexpressed ABCB1, ABCC1, or ABCG2. To be a substrate for a transporter, uptake... . The three pairs were (listed as parental and resistant, respectively): KB-3-1 and KB-8-5-11 (ABCB1, also... -resistant cell lines were additionally cultured in the following cytotoxic ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
23 STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines
 

Summary:  ). In addition, the functional activity of drug efflux proteins including ABCB1 was measured as internal accumula... to Doxorubicin and exhibits clas- sical MDR phenotype with overexpression of ABCB1.10 The re- sistant phenotype... Hs01013989_m1), IFI27 (Assay ID Hs00271467_m1) and ...

  

Source: Uppsala Universitet, Department of Material Science, Signals and Systems Group

 

Collection: Engineering

 
24 368 VOLUME 86 NUMBER 4 | OCTOBER 2009 | www.nature.com/cpt STATE ART nature publishing group
 

Summary:  -gp (ABCB1), ABCG2, and sev- eral transporters of the ABCC family, most of which are apically (blood... , ABCB1 has been most studied because it encodes P-glycoprotein ((P-gp) or multidrug resistance 1 (MDR1... to describe a drug transported by ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
25 ANRS12154Pecan_NVP_v1_dernier enregistrement par Anne-Marie Population pharmacokinetic-pharmacogenetic study of1
 

Summary:  enregistrement par Anne-Marie glycoprotein efflux transporter (1). CYP3A5, CYP2B6 and ABCB1 (MDR1, which endcodes... with decreased transport function. Consequently10 homozygous CYP3A5 6986GG, CYP2B6 516TT or 1459TT and ABCB1 3435... focusing on the5 CYP2B6, CYP3A5 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
26 236 nature genetics volume 24 march 2000 A gene expression database for the
 

Summary:  on drugs that it can transport out of the cell8,15,21­24. Because ABCB1 is expressed at significant levels... gene ABCB1 (formerly MDR1) had closely related drug-activity profiles. HCT-15, with one of the highest... levels of ...

  

Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University; Brown, Patrick O.- Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine ; Biotechnology

 
27 The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals
 

Summary:  . hamnerorum ABC transporters agreed well with human ABCB1 and ABCC3 models (Figs. S3, S4 in the Supplementary... of mammalian ABCB1 in barrier tissues coupled with its function as a unidirectional transporter of a range... with human ...

  

Source: Sotka, Erik - Grice Marine Laboratory, College of Charleston

 

Collection: Environmental Sciences and Ecology

 
28 Comparison of [11 C]-(R)-PK 11195 and [11
 

Summary:  pair selectively overexpressed ABCB1, ABCC1, or ABCG2. To be a substrate for a transporter, uptake... . The three pairs were (listed as parental and resistant, respectively): KB-3-1 and KB-8-5-11 (ABCB1, also... -resistant cell lines were additionally cultured in the following cytotoxic ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health

 

Collection: Biology and Medicine

 
29 Drug metabolism in human and rat intestine: An in vitro approach
 

Summary:  (submitted for publication) 139 Chapter 8 Coordinated regulation of drug metabolizing enzymes, transporters... of the intestine, are able to metabolize and transport endogenous and exogenous compounds [4-7]. Drug metabolism... and transporters in the intestinal tract Although the liver ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with
 

Summary:  studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... found that dLop is selective for P-gp (ABCB1) among the 3 most common ABC transporters at the blood... ­brain barrier ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
31 Coordinated regulation of drug metabolizing enzymes, transporters and nuclear receptors
 

Summary:  UGT1A6 (4-fold), also mRNA expression of the transporters MDR1/ABCB1 (2.5-fold), MRP3/ABCC3 (4.3-fold... Chapter 8 Coordinated regulation of drug metabolizing enzymes, transporters and nuclear receptors... ;Chapter 8 156 Abstract The sensitivity of drug metabolizing ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
32 Hormone Transport Ian D. Kerr, David J. Carrier and Jamie Twycross
 

Summary:  postulated to be auxin transporters in plants, viz ABCB1, ABCB4 and ABCB19. Mutants in Atpgp1 (encoding ABCB1... expression patterns of ABCB1, B19 and B4 are also consistent with a role in root auxin transport, being... ...

  

Source: Twycross, Jamie - School of Computer Science, University of Nottingham

 

Collection: Computer Technologies and Information Sciences

 
33 Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal
 

Summary:  | efflux The efflux transporter P-glycoprotein (P-gp; encoded by ABCB1) blocks the entry of various... to elucidate the mechanism of transport by P-glycoprotein (ABCB1). J Biol Chem 281:26501­26511. 15. Pfister JR... -glycoprotein (P-gp), a ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
34 Summary and outlook H. Bart van den Berg van Saparoea and Arnold J.M. Driessen
 

Summary:  fermentation in wine making, #12;80 and MDR1 (ABCB1 or P-glycoprotein), a human MDR protein. The presence... in the chemotherapeutic treatment of cancer, and this is based on MDR transporters that are related to and function... drugs. Before the genetic basis of the MDR phenotype in L. lactis was discovered, ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
35 Oxidoreductase HepG2 Huh7 Hepatocytes
 

Summary:  such genes as C/EBP, HNF4, CYP2D6, and ABCB1. In contrast, HepG2 and Huh7 cells were unchanged from the liver... hepatic transport across basolateral and canalicular domains of the plasma membrane1,3, and expression... and activity of drug metabolizing enzymes2, 5, 6. Despite these reports, the specific ...

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
36 UNIVERSIT PARIS.DIDEROT (Paris 7) COLE DOCTORALE : 393
 

Summary:  'excrétion d'un nombre important de médicaments (Marzolini et al., 2003). Le gène ABCB1 codant pour la P... populations caucasiennes et la fréquence du variant C3435T du gène ABCB1 est de respectivement 80% et 50% dans... simulés sont ceux des exons 26 et 21 du gène ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
37 Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal
 

Summary:  | efflux The efflux transporter P-glycoprotein (P-gp; encoded by ABCB1) blocks the entry of various... to elucidate the mechanism of transport by P-glycoprotein (ABCB1). J Biol Chem 281:26501­26511. 15. Pfister JR... -glycoprotein (P-gp), a ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
38 In vitro methods to study intestinal drug metabolism
 

Summary:  transporters increase (MDR1 (Pgp/ABCB1) [17-19], MRP1 (ABCC1 [19]), OCTN2 [20]), decrease (BCRP (ABCG2 [21... compounds. Furthermore, the relevance of drug transporters in this process has been proven. Only a few... . Their applicability to study phase I-III ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
39 ABC transporters ABC transporter architecture and regulatory roles of
 

Summary:  /3), human peptide transporter; PDR5, yeast pleiotropic drug resistance transporter; P-gp (MDR1/ABCB1), human... -glycoprotein (P-gp/MDR1/ABCB1) activity. Irrespective of the direction of transport (uptake or excretion... ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
40 10.1177/0091270004269705ARTICLEKHARASCH ET ALEVALUATION OF CYP3A AND P-GLYCOPROTEIN ACTIVITIES USING ALFENTANIL AND FEXOFENADINEDRUG METABOLISM AND TRANSPORT Evaluation of First-Pass Cytochrome P4503A
 

Summary:  exhib- its marked interindividual variability, owing to widely DRUG METABOLISM AND TRANSPORT J Clin... effect.7-10 P-glycoprotein (P-gp), the product of the MDR1 (ABCB1) gene, is an adenosine triphosphate... /10 mM formic acid (3:7), and transferred to autosampler vials. DRUG METABOLISM ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine


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41 Place du test de permutation dans les mod`eles non lineaires `a effets mixtes : application en
 

Summary:  aussi ´et´e g´enotyp´es pour 5 polymorphismes : ABCB1 exon 26 et 21, CYP3A5*3, CYP3A5*6 et CYPA4*1B... polymorphismes simul´es sur un des param`eres du mod`ele sont inspir´es des exons 26 et 21 du g`ene ABCB1, soit... mixtes, SAEM, Tests, Permutations Pharmacokinetics studies the time course of a ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
42 P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with
 

Summary:  studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... found that dLop is selective for P-gp (ABCB1) among the 3 most common ABC transporters at the blood... ­brain barrier ...

  

Source: McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health

 

Collection: Biology and Medicine

 
43 Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric Dimers
 

Summary:  1/ABCB1), chosen because it shares many of the same transport substrates as ABCG2. The third... were expressed at the plasma membrane and maintained drug transport activity. Expression of an ABCG2... experiments and were functional for drug ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
44 COMPARATIVE MEDICINE LABORATORY ANIMAL FACILITIES
 

Summary:  SUPERVISION DURING TRANSPORTATION AND STORED IMMEDIATELY IN A DEPARTMENT SAFE OR CONTROLLED DRUG CABINET... for CONTROLLED DRUG PROCUREMENT 1.0 Purpose This procedure provides instruction to anyone wishing to purchase... a whole bottle(s) of controlled drug under the CMLAF DEA license number 2.0 Scope This ...

  

Source: Krovi, Venkat - Department of Mechanical and Aerospace Engineering, State University of New York at Buffalo

 

Collection: Engineering

 
45 The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome
 

Summary:  the multidrug transporters due to their ability to pump out multiple therapeutic drugs, a major obstacle... from eggs is Sp-ABCB1 (SPU_001752, 27 exons spanning 32 kb of genomic DNA). This gene is one of 12 ABCB... genes present in the sea urchin and is orthologous to mammalian ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
46 Circadian Timing in Cancer Treatments
 

Summary:  3A4 UGT1A1 DPYD GSH ABCB1 ABCC2 ABCG2 Metabolism and detoxification Drug metabolism and target Drug... ) determines the optimal circadian timing of anticancer medications (bottom). The CTS controls drug transport... family members, including ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine

 
47 Aquatic Animal Drug Approval Partnership: In Pursuit of Aquaculture Drug Approvals Legal and Judicious
 

Summary:  animals treated with the drug ­ Permits the legal interstate transport of the drug Aquatic Animal Drug... Aquatic Animal Drug Approval Partnership: In Pursuit of Aquaculture Drug Approvals Legal... and Judicious Use of Drugs and Therapeutants in ...

  

Source: Southern Illinois University, Fisheries and Illinois Aquaculture Center

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
48 Bivalent Probes of the Human Multidrug Transporter P-Glycoprotein Marcos M. Pires, Christine A. Hrycyna,* and Jean Chmielewski*
 

Summary:  of transport. In addition to acting as probes of P-gp's drug binding sites, these agents were also potent... -binding cassette) transporters. P-gp uses the energy of ATP hydrolysis to pump drug molecules out of cells so... are essential for the proper function- ing of P-glycoprotein, including ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
49 This journal is c The Royal Society of Chemistry 2011 Mol. BioSyst. Cite this: DOI: 10.1039/c0mb00326c
 

Summary:  .8 Glucosidase (predicted) pmd1 ABCB1 (P-glycoprotein 1) Resistant 100.4 ABC transporter family ura3 DHODH... ,26 To identify nonspecific drug efflux pumps, we examined the effects of a series of ABC transporter deletion... relatively Table 1 The MIC values against ABC ...

  

Source: Boone, Charlie - Department of Molecular and Medical Genetics, University of Toronto

 

Collection: Biotechnology

 
50 Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap-
 

Summary:  or cellular efflux of drugs. Transporters play an important role in drug disposition as drugs can only... be metabolized after they are transported into the liver cells. However, transporter-based drug interactions... expand our approach to in- ...

  

Source: Baral, Chitta - Department of Computer Science and Engineering, Arizona State University

 

Collection: Computer Technologies and Information Sciences

 
51 nAture methods | VOL.8 NO.2 | FEBRUARY2011 | 159 Phenotypes that might otherwise reveal a gene's function
 

Summary:  , I., Kroetz, D.L. & Rine, J. Function-altering SNPs in the human multidrug transporter gene ABCB1... - ceuticals. For example, ATP-binding cassette (ABC) transporters overlap in the drugs they export. To isolate... for characterizing exogenous transporters7. ...

  

Source: Harvard University, Center for Cancer Systems Biology; Roth, Frederick - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine ; Biotechnology

 
52 For personal use. Only reproduce with permission from The Lancet Publishing Group. MECHANISMS OF DISEASE
 

Summary:  for two members of the superfamily of ATP- binding-cassette transporters (ABCB1 and ABCC4) were recorded... BMP7 RARG SPRY1 CEP2 GUCY1A3 MYO6 ABCC4 PCAF Protein kinase C KIT SPRY4 INPP5a PTP4A3 ABCB1 DNCI1... type 4A 3 RAB3a RAS-associated protein RAB3A ...

  

Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University; Sherlock, Gavin - Department of Genetics, Stanford University; Utah, University of - Scientific Computing and Imaging Institute

 

Collection: Biology and Medicine ; Computer Technologies and Information Sciences

 
53 10.1177/0091270003262075ARTICLEKHARASCH ET ALFENTANYL AND P-GLYCOPROTEINDRUG METABOLISM Quinidine as a Probe for the Role of
 

Summary:  G, et al: Effects of ABCB1 (multidrug resistance transporter) gene muta- tions on disposition... of intestinal epithelial cells, where it ac- tively transports drugs back into the gut lumen and limits... transports several bioactive amines and nitrogen-containing ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
54 tel-00628629,version1-3Oct2011 tel-00628629,version1-3Oct2011
 

Summary:  'enzyme de désactivation UGT1A1, et les quatre transporteurs ABCB1, ABCC1, ABCC2, ABCG2. Au contraire, l... le transport du CPT11. Après synchronisation des cellules par choc sérique, qui définit le temps cir... -FU : 5-Fluorouracil ­ ABC transporter : ATP-Binding Cassette transporter ...

  

Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique

 

Collection: Physics

 
55 Multidrug and peptide export in Lactococcus lactis
 

Summary:  transporter ABCB1 (P-glycoprotein or MDR1) is a full- transporter in which a single polypeptide encompasses... transporters and when aligned with both the N- and C-terminal halves of the human ABCB1, approximately one... define the function of ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
56 Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression
 

Summary:  transport has primarily been associated with P-glycoprotein (ABCB1), Breast Cancer Resistance Protein (BCRP... regions of transporter genes contribute to observed variation in drug response. A total of 579... for the transport of drugs and other ...

  

Source: 

 

Collection: Biology and Medicine ; Biotechnology

 
57 Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues
 

Summary:  , as transporters, such as P-glycoprotein (ABCB1), the bile salt export pump (ABCB11), multidrug resistance... , representing such genes as C/EBP, HNF4, CYP2D6, and ABCB1. In contrast, HepG2 and Huh7 cells were unchanged... of the hepatoma cell lines that were subjected to analysis (Fig. ...

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
58 This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  results support these findings, as transporters, such as P-glycoprotein (ABCB1), the bile salt export pump... -represented categories, representing such genes as C/EBP, HNF4, CYP2D6, and ABCB1. In contrast, HepG2 and Huh7 cells were... , 203924_at; GPX1, 200736_s_at; ...

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
59 14 Bushan, M. et al. (2002) Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial. Br. J. Dermatol. 146, 824831
 

Summary:  , genes involved in drug transport [e.g. polymorphisms in the gene encoding P-glycoprotein 1 (ABCB1... ) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409, 202­207 9 Communi, D... .A. and Simon, J. (2001) An elusive receptor is finally caught: P2Y12, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
60 In Silico Prediction of Drug Transport Across Physiological Barriers
 

Summary:  In Silico Prediction of Drug Transport Across Physiological Barriers Inauguraldissertation zur... , and active drug transport by the ATP binding cassette (ABC) transporter MRP2. In addition, a nature inspired... could be related to an active drug ...

  

Source: Amrhein, Valentin - Zoologisches Institut, Universität Basel

 

Collection: Environmental Sciences and Ecology


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61 Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes
 

Summary:  . Few reports on the involvement of drug transporters in methadone disposition are available beyond... current results, studies on the effects of other drug transporters on methadone disposition appear... one-to-one by metabolite formation. This result does not exclude drug ...

  

Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University

 

Collection: Biology and Medicine

 
62 UNIVERSIT PARIS XI FACULT DE PHARMACIE DE CHTENAY-MALABRY
 

Summary:  Lopinavir LTC4 Leucotriène C4 LTR « Long terminal repeat » MCT « Monocarboxylate transporter » MDR... du système de transport d'efflux de la BHE tel-00364246,version1-25Feb2009 #12;11 Liste des tableaux

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
63 Phenotype-Based Screening of Mechanistically Annotated Compounds in Combination with Gene Expression and Pathway
 

Summary:  , of doxorubicin once a month and overexpresses Pgp/MDR1/ABCB1.11 The 8226/LR5 subline was exposed to 1.53 µg... Expression and Pathway Analysis Identifies Candidate Drug Targets in a Human Squamous Carcinoma Cell Model... of squamous cell carcinoma. (Journal of Biomolecular Screening 2006:457-468) Key words: ...

  

Source: Uppsala Universitet, Department of Material Science, Signals and Systems Group

 

Collection: Engineering

 
64 Chemistry and Physics of Lipids 141 (2006) 119132 Proteins involved in lipid translocation in eukaryotic cells
 

Summary:  (2003) -idem ABCA1 PS, chol. Yes Hamon et al. (2000) Mice erythrocytes ABCB1 P-glycoprotein (MDR1) Low... in eukaryotes has been generally assigned to ATPases from the ABC superfamily of proteins such as ABCB1 commonly... a floppase activity in epithelial cells expressing MDR1or MDR3 (now named, ...

  

Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques

 

Collection: Chemistry ; Biology and Medicine

 
65 Concluding Remarks and Perspectives 8.1. Concluding remarks
 

Summary:  phase in the drug-rich layer, C is crystallised drug, D is the stagnant layer transporting the drug via... , the dissolution of the matrix as measured during the experiment has to be used to calculate the drug transport... from the solid dispersion to the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
66 Summary and concluding remarks Microorganisms have developed multiple strategies to resist the
 

Summary:  ) active extrusion of drugs by transport proteins present in the cell membrane (Fig. 1). LmrP is one... of such transporters that extrude a wide variety of cationic drugs. It consists of 408 amino acids organized in 12... of drug target (T); C, prevention of drug ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
67 ForPeerReview Expression, localization, and inducibility by bile acids of hepatobiliary transporters in
 

Summary:  ) for the efflux pumps Mdr1b/Abcb1b, Mdr2/Abcb4, Mrp1/Abcc1, Mrp2/Abcc2, Mrp3/Abcc3, Abcg5, Abcg8. This profile... reasons. Firstly, whereas most in vivo experiments on bile transport and biliary elimination of drugs... expression of drug transporters and its role in ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
68 Systematic exploration of synergistic drug pairs Murat Cokol1,2,
 

Summary:  Systematic exploration of synergistic drug pairs Murat Cokol1,2, *, Hon Nian Chua1,3 , Murat Tasan1... 5545; E-mail: fritz.roth@utoronto.edu Received 13.7.11; accepted 11.8.11 Drug synergy allows... a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when ...

  

Source: Roth, Frederick - Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biotechnology ; Biology and Medicine

 
69 Advanced Drug Delivery Reviews 48 (2001) 137138 www.elsevier.com/locate/drugdeliv
 

Summary:  with the mathematical treatment of drug triggered transport (swelling) and degradation/ero- transfer through mucus... Advanced Drug Delivery Reviews 48 (2001) 137­138 www.elsevier.com/locate/drugdeliv Preface... Mathematical modeling of controlled drug delivery Mathematical modeling of controlled ...

  

Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin

 

Collection: Biology and Medicine ; Materials Science

 
70 ORIGINAL ARTICLE Global variation in CYP2C8CYP2C9 functional
 

Summary:  , and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel. Clin Cancer Res 2005; 11: 8097­8104. 12... and drug transporters in chemotherapy. Methods Mol Biol 2008; 448: 63­76. 27 Daly AK. Pharmacogenetics... - nomic implications for drug interactions. The Pharmacogenomics Journal ...

  

Source: Kidd, Kenneth - Department of Genetics, Yale University

 

Collection: Biology and Medicine

 
71 A survey of integral a-helical membrane proteins Libusha Kelly Ursula Pieper Narayanan Eswar
 

Summary:  as in the human transporters ABCB1, ABCB11 and ABCB4 (Supplemen- tary Fig. 2). The most similar structurally... the rationale for their inclusion into the target list. In humans, ABCB1 (also known as MDR1) and other members... and families of particular interest, such as the diversity of ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
72 Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes in
 

Summary:  for cystic fibrosis.6 Some ABC proteins, such as MDR1 (ABCB1), MRP1 (ABCC1) and BCRP (ABCG2), are commonly... ., Kohno, K. & Wada, M. (1999). Multidrug resistance-associ- ated protein subfamily transporters and drug... Expression Analysis of ABC Transporters Reveals Differential ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
73 Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School
 

Summary:  statute which prohibits transport offederal statute which prohibits transport of unapproved drugs... the Pharmaceutical Industry History, Pricing, Drug Pipeline, Blockbuster Drugs, Legislative Trends, Federal Courts... History, Pricing, Drug Pipeline, Blockbuster ...

  

Source: Schutt, Clarence E.- Departments of Chemistry & Molecular Biology, Princeton University

 

Collection: Chemistry ; Biology and Medicine

 
74 Abstract. The typically distinct phospholipid composi-tion of the two leaflets of a membrane bilayer is generated
 

Summary:  transporter ABCB1 translocated a wide variety of short chain lipids [110­113], including the short chain PC... that transport a broad range of substrates, includ- ing ions, sugars, drugs and peptides across cellular mem... platelet-activat- ing factor [114, 115]. The ...

  

Source: Menon, Anant K. - Menon Lab, Weill Medical College, Cornell University

 

Collection: Biology and Medicine

 
75 Pharmaceutical Chemistry B.S. 1. General description and characteristics of the program.
 

Summary:  emphasizes the chemistry of drug design and development, drug action, drug transport, drug delivery... of biological processes and mechanisms of drug action. Progress in the field now depends on the design... , and computer-aided drug design. In ...

  

Source: Michigan Technological University, School of Forest Resources and Environmental Science, Aspen FACE (Free-Air Carbon Dioxide Enrichment) Experiment

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
76 Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells
 

Summary:  of the amplified MDR1 (ABCB1) gene in drug- resistant variants of a human sarcoma. Genes Chromosomes Cancer 2002... Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells... - taneously resistant against cytotoxic drugs at rates of up to 1023 per ...

  

Source: Duesberg, Peter - Department of Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine

 
77 DOI: 10.1126/science.1167625 , 1714 (2009);323Science
 

Summary:  -facing conformation represents an initial stage of the transport cycle that is competent for drug binding. T he... three molecular "pumps" that actively transport drugs out of the cell (3). The most prevalent... because of its clinical relevance. We describe the structure of mouse P-gp ...

  

Source: Martin, Ellen - Department of Geological Sciences, University of Florida

 

Collection: Geosciences

 
78 Press Release Corporate Communications
 

Summary:  .ch@pvw.tu-darmstadt.de www.tu-darmstadt.de/presse presse@tu-darmstadt.de New Substances Accelerate Drug Transport Into Cells... for speeding the transport of the active ingredients of drugs into live cells that might allow drastically... transport drugs faster In an ...

  

Source: Hoffmann, Rolf - Fachbereich Informatik, Technische Universität Darmstadt

 

Collection: Computer Technologies and Information Sciences

 
79 Personalized Medicine: Marking a New Epoch in Cancer Patient Management
 

Summary:  subgroups of cancer patients. Variations in genes that encode drug-metabolizing enzymes, drug transporters... to identify unique molecular targets for drug design. Such strategies will reduce the cost of lead discovery... , reduce the timeline and costs of clinical trials, and potentially revive ...

  

Source: 

 

Collection: Biotechnology ; Biology and Medicine

 
80 A mechanistic model of controlled drug release from polymer millirods: Effects of excipients and complex binding
 

Summary:  with these devices have examined the control of drug release [3,4] and drug transport in tissues [3... incorporates the essential transport and kinetic processes underlying the drug release from the polymeric... A mechanistic model of controlled drug release from ...

  

Source: Gao, Jinming - Department of Oncology and Pharmacology, University of Texas Southwestern Medical Center at Dallas

 

Collection: Biology and Medicine


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81 Solid dispersions offer a drug delivery platform that may overcome problems related to the absorption of poorly water-soluble drugs in-vivo. This is ascribed to
 

Summary:  dissolution rate was reached: the transport of dissolved drug to the drug-rich layer was balanced... 149 Chapter 9 Summary Solid dispersions offer a drug delivery platform that may overcome problems... related to the absorption of poorly water-soluble drugs in-vivo. This is ascribed to ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
82 List of publications Full papers
 

Summary:  IAM, Ungell ALB, Groothuis GMM: Coordinated regulation of drug metabolizing enzymes, transporters... precision-cut slices, 1 st Eufeps conference on drug transporters, Barcelona, Spain, April 2005 4. Van de... , De Graaf IAM, De Jager MH, Groothuis GMM: Induction of drug metabolising ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
83 MISSISSIPPI STATE UNIVERSITY DRUG AND ALCOHOL FREE WORKPLACE POLICY
 

Summary:  MISSISSIPPI STATE UNIVERSITY DRUG AND ALCOHOL FREE WORKPLACE POLICY INTRODUCTION AND PURPOSE... Mississippi State University implements this drug and alcohol policy and conducts a testing program pursuant... to Sections 71-7-1, et seq., of the Mississippi Code of 1972, Ann., entitled "Drug and Alcohol Testing

  

Source: Mississippi State University, Center for Advanced Vehicular Systems (CAVS)

 

Collection: Engineering

 
84 Revision of existing Code. Approved October 2009.
 

Summary:  hazardous substances or transportable gases if affected by drugs. 3.5 The Occupational Health Unit... WCP1 Drugs Revision of existing Code. Approved October 2009. 1 Health and Safety Unit Health... and Safety Codes of Practice Welfare Code Drugs #12;WCP1 Drugs Revision of existing Code. ...

  

Source: Brown, Richard - School of Biological and Earth Sciences, Liverpool John Moores University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
85 836 Current Drug Metabolism, 2009, 10, 836-841 1389-2002/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  the drugs into the extracellular space. Therefore, overexpression of multidrug transporters enables a rapid... mechanisms that are due to multidrug transporters such as P-gp. In MDR cells, transmembrane drug-efflux pumps... 836 Current Drug Metabolism, 2009, 10, 836-841 1389-2002/09 ...

  

Source: Zhang, Liangfang - Department of Nanoengineering, University of California at San Diego

 

Collection: Materials Science

 
86 European Journal of Pharmaceutical Sciences 9 (1999) 3340 www.elsevier.nl/locate/ejps
 

Summary:  Published by Elsevier Science B.V. All rights reserved. Keywords: Drug transport; Swelling; Polymer... . In fact, solid drug transport has been already observed and de- scribed by Colombo et al. (1997... of a significant polymer transport, often associated with chain relaxation, which ...

  

Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin

 

Collection: Biology and Medicine ; Materials Science

 
87 Genome Biology 2007, 8:R131 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation
 

Summary:  , KL), corticosteroid/daunorubicin transport (ABCB1), modification of cholesterol (ABCB1, SULT2B1... ), transport of fludarabine (SLC28A2), hydrocortisone uptake (ABCB1), formation of aberrant crypt foci (NR5A2... ), ...

  

Source: Dove, William - McArdle Laboratory for Cancer & Department of Medical Genetics, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
88 Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 Is Required for Polar Auxin Transport C W
 

Summary:  -1, aux1-7, and abcb1. Each of these mutants is affected in gravitropism due to a defect in auxin... plants (Oono et al., 1998; Gray et al., 2001). The axr2-1, abcb1/ pgp1, and aux1-7 mutants have been... 7 (at3g23050), ABCB1/PGP1 (at2g36910), PIN1 (at1g73590), PIN2 ...

  

Source: Prigge, Michael J. - Division of Biological Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
89 Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 Is Required for Polar Auxin Transport C W
 

Summary:  -1, aux1-7, and abcb1. Each of these mutants is affected in gravitropism due to a defect in auxin... plants (Oono et al., 1998; Gray et al., 2001). The axr2-1, abcb1/ pgp1, and aux1-7 mutants have been... 7 (at3g23050), ABCB1/PGP1 (at2g36910), PIN1 (at1g73590), PIN2 ...

  

Source: Estelle, Mark - Division of Biological Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
90 Rehabilitation Program for Alcohol and Drug Abuse revised 05/20/09 #751 Page 1 of 2
 

Summary:  Rehabilitation Program for Alcohol and Drug Abuse revised 05/20/09 #751 Page 1 of 2... Rehabilitation Program for Alcohol and Drug Abuse Texas A&M University is committed to protecting the health... and safety of its employees. Because alcohol and drug abuse is a significant problem in the United States

  

Source: Texas A&M University, Spatial Sciences Laboratory

 

Collection: Geosciences

 
91 Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
 

Summary:  * and Mary V. Relling Genetic polymorphisms in drug-metabolizing enzymes, transporters, re- ceptors... - morphisms of drug-metabolizing enzymes are so common. Genetic Polymorphisms in Drug Transporters Although... and elimination, the clinical rele- vance of polymorphisms in ...

  

Source: Hahn, Mark E. - Biology Department, Woods Hole Oceanographic Institution

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
92 Introduction: Production, stability, and dissolution of solid dispersions to improve
 

Summary:  by the dissolution of the drug and the subsequent transport over the intestinal membrane and passage of the liver... -I drugs dissolve rapidly in an aqueous environment and are rapidly transported over the absorbing membrane... depends on the transport mechanism over the membrane. When ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
93 As a recipient of federal funds, Georgia Southern University supports and complies with the provisions of the Drug Free Schools and Communities Act Amendments of 1989 and the Drug Free Workplace Act of 1988. In
 

Summary:  with the provisions of the Drug Free Schools and Communities Act Amendments of 1989 and the Drug Free Workplace Act... possession, use, or distribution of illicit drugs and alcohol by students and employees. To comply... possession, manufacture, distribution, dispensation, or use of illicit drugs and alcohol ...

  

Source: Hutcheon, James M. - Department of Biology, Georgia Southern University

 

Collection: Environmental Sciences and Ecology

 
94 Project: In silico Modelling of Drug-Membrane Interactions: Predicting Non Specific Binding The Chemical Biology (http://www.chemicalbiology.ac.uk/) Doctoral Training Centre is inviting
 

Summary:  you will test novel experimental theories on drug transport proposed at Imperial and GSK plc... Project: In silico Modelling of Drug-Membrane Interactions: Predicting Non Specific Binding... the behavior of drug molecules in vivo. A deeper understanding of the molecular basis of non specific binding

  

Source: Rosso, Lula - Department of Chemistry, Imperial College, London

 

Collection: Chemistry ; Biology and Medicine

 
95 Seminars in Immunology 15 (2003) 257270 Chemokine regulation of naive T cell traffic in health and disease
 

Summary:  transporter Abcb1 (MDR-1, P-glycoprotein) and the leukotriene C4 transporter Abcc1 (MRP-1 [95]). Blocking... either of these channels with pharmacologic in- hibitors or using T cells from Abcb1 or Abcc1-deficient... leukotrienes. Thus, a model of sequential ...

  

Source: von Andrian, Ulrich H. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
96 323ISSN 2041-599010.4155/TDE.10.13 2010 Future Science Ltd Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology
 

Summary:  therapeutics in the last two decades. Advances in biocompatible nanoscale drug carriers such as liposomes... and polymeric nanparticles have enabled more effi- cient and safer delivery of a myriad of drugs. Advantages... in nanoparticle drug delivery, par- ticularly at the systemic level, include longer cir- culation half

  

Source: Zhang, Liangfang - Department of Nanoengineering, University of California at San Diego

 

Collection: Materials Science

 
97 This Provisional PDF corresponds to the article as it appeared upon acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon.
 

Summary:  drug targets based on simple sequence properties BMC Bioinformatics 2007, 8:353 doi:10... drug targets based on simple sequence properties Qingliang Li1, 2 and Luhua Lai1, 2* 1 Beijing National... , research and development in drug discovery have attracted much attention and efforts. However, only 324

  

Source: Luhua, Lai - Institute of Physical Chemistry, Peking University

 

Collection: Chemistry ; Biotechnology

 
98 Annu. Rev. Ecol. Evol. Syst. 2005. 36:16989 doi: 10.1146/annurev.ecolsys.36.102003.152617
 

Summary:  of elimination processes such as enzymes, transporters, and renal excretion. The elimination of probe drugs... transporters. Drug Metab. Rev. 36:595­615 Boyle R. 2000. Metabolic fate of dietary ter- penes in folivorous... of PSMs across intestinal cells can be regulated by two molecular mechanisms, a glyco- ...

  

Source: Foley, Bill - School of Botany and Zoology, Australian National University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
99 3 MAY 2002 VOL 296 SCIENCE www.sciencemag.org838 The cell membrane has a tough job. A mere
 

Summary:  excluding others. Already, one drug designed to take advantage of a specific transport mechanism has reached... , charge, or chemical composition. Hijacking a transporter seems a promis- ing way to get a drug across... . Chemists at drug company Roche used the same approach to make ...

  

Source: Akhmedov, Azer - Department of Mathematics, University of California at Santa Barbara

 

Collection: Mathematics

 
100 Nederlandse samenvatting De bestrijding van infectieziekten met behulp van antibiotica (hier
 

Summary:  om informatie te verkrijgen omtrent de functie van deze bacteriële MDR-transporter. Het aantal drugs... energie nodig voor het transport van positief geladen drugs geleverd kan worden door een electrische... plaats vindt is echter nog niet opgehelderd. Het transport van de ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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