| Sample search results for: abcb1 drug transporters |
| 1 | Reduced intracellular accumulation of calcein by overexpression of fluorescent protein fusions of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos. | ||
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Summary: of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos. Amro Hamdoun1 1... fluorescent protein (FP) fusions of the candidate sea urchin P-gp transporter Sp-ABCB1a, and then to determine... of the up-regulated activities is ... |
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Source: |
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Collection: Environmental Sciences and Ecology |
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| 2 | Clin Pharmacol Ther . Author manuscript Donor P-gp polymorphisms strongly influence renal function and graft | ||
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Summary: 3A and the efflux transporter P-glycoprotein (P-gp; ), bothABCB1 abundantly expressed in the kidney... of the efflux transporter P-glycoprotein (P-gp; gene) extruding xenobiotics1 ABCB1 from the cell ( ). The most... independently of its effect on the ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 3 | Donor P-gp polymorphisms strongly influence renal function and graft loss in a cohort of renal transplant recipients with long term follow-up. | ||
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Summary: transporter P- glycoprotein (P-gp; ABCB1), both abundantly expressed in the kidney. We retrospectively... transplantation (1). CsA is a substrate of the efflux transporter P-glycoprotein (P-gp; ABCB1 gene) extruding... investigated the role of polymorphisms in ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 4 | Response to "PREDICTABLE DIFFICULTY OR DIFFICULTY TO PREDICT" by Tams Arnyi, Krisztina Fulop, Orsolya Symmons, Viola Pomozi, and Andrs Vradi | ||
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Summary: classification as "disease-associated" is not justified. Mutant V1251I of ABCB1 showed decreased transport... -altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay. PLo... arguing against an unequivocal ... |
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Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine ; Biotechnology |
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| 5 | N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the | ||
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Summary: -brain barrier, the three most prevalent ABC transporters are P-glycoprotein (P-gp) (encoded by ABCB1), multidrug... transporters that block the passage of drugs across the blood- brain barrier. The three most prevalent ATP... in cytotoxicity of drugs effluxed at each ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 6 | N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the | ||
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Summary: -brain barrier, the three most prevalent ABC transporters are P-glycoprotein (P-gp) (encoded by ABCB1), multidrug... transporters that block the passage of drugs across the blood- brain barrier. The three most prevalent ATP... in cytotoxicity of drugs effluxed at each ... |
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Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 7 | A Resource to Acquire and Summarize Pharmacogenetics Knowledge in the Literature Daniel L. Rubin, Michelle Carrillo, Mark Woon, John Conroy, Teri E. Klein, and Russ B. Altman | ||
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Summary: , then all the drugs and diseases associated with ABCB1 are shown (Figure 2). Clicking on the "Details... are shown, allowing the user to quickly determine how the various drugs and diseases are related to ABCB1... . This display shows that digoxin and prednisone ... |
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Source: Rubin, Daniel L. - Department of Radiology, Stanford University |
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Collection: Biology and Medicine |
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| 8 | Precision-cut slices as a tool to study induction of drug metabolism | ||
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Summary: , CYP3A4, 17- HSD) and phase II metabolism (UGT1A6) and phase III transport (MDR1/ABCB1). In addition... Predictive in vitro methods to investigate induction of drug metabolizing enzymes and transporters... (2-fold), UGT1A6 (2.2 and 32-fold) and ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 9 | PharmGKB Submission Update: IV. PMT Submissions of Genetic Variations in ATP- | ||
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Summary: and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Phar- macogenetics 13... into these restricted sites. The overexpression of some ABC transporters is associated with drug resistance in tumors... or blood for elimination or distribution. Summary of ... |
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Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine ; Biotechnology |
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| 10 | Published on Web Date: October 21, 2010 r 2010 American Chemical Society 82 DOI: 10.1021/cn100078a |ACS Chem. Neurosci. (2011), 2, 8289 | ||
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Summary: transporter ABCB1. Recent positron emis- sion tomographic brain imaging studies using [11 C]- tariquidar... reaction to elucidate the mechanism of transport by P-gly- coprotein (ABCB1). J. Biol. Chem. 281, 26501... to measure ... |
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Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 11 | Function of prokaryotic and eukaryotic ABC proteins in lipid transport Antje Pohla,b | ||
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Summary: and Gottesmann [1] pointed out that ABCB1 (MDR1 Pgp) behaved like a bflippaseQ which would be able to transport... of structurally unrelated drugs. ABCB1 is involved in other phenomena as well, in which, interestingly, lipid... to the outward ... |
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Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques |
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Collection: Chemistry ; Biology and Medicine |
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| 12 | Applied Mathematics Letters 24 (2011) 12511256 Contents lists available at ScienceDirect | ||
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Summary: responsible for CPT11 efflux and stands for the cumulative activity of ABCB1, ABCC1 and ABCC2. Transporters... -modulated ABC transporter induction CPT11 exposure may enhance the expression of ABCB1 and ABCG2 both... Drug-driven ... |
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Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt |
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Collection: Biology and Medicine |
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| 13 | Introduction to multidrug transporters, cellular resistance and lantibiotic production in Lactococcus lactis | ||
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Summary: transporter ABCB1 (P-glycoprotein or MDR1) is a full- transporter in which a single polypeptide encompasses... transporters and when aligned with both the N- and C-terminal halves of the human ABCB1, approximately one... define the function of ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 14 | J Biopharm Stat. Author manuscript Comparison of model-based tests and selection strategies to detect | ||
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Summary: therapeutic drug monitoring in anti-retroviral therapy. Since the ABCB1 genetic polymorphism was found to have... the subject of much attention, for example the ABCB1 gene coding for the PLicinio and Wong, 2002 glycoprotein... , Yamaguchi and colleagues demonstrated the impact of ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 15 | Model-based tests for pharmacogenetic analyses Comparison of model-based tests and selection strategies to detect genetic | ||
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Summary: of early therapeutic drug monitoring in anti-retroviral therapy. Since the ABCB1 genetic polymorphism... (Licinio and Wong, 2002). Some genes have already been the subject of much attention, for example the ABCB1... recently, Yamaguchi and colleagues demonstrated the impact of ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 16 | Ecole Polytechnique Thse de doctorat | ||
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Summary: .3 ABCA12 2q34 ABCA/ABC1 ABCA13 7p12.3 ABCB1 MDR1, P-gp, ABC20, GP170, PGY1 7q21.1 ABCB2 TAP1, PSF1, RING4... 2 NH2 COOH a) ABCC7/CFTR ABCB1/P-gP ABCC1/MRP1 ABCB2-3/TAP R b) R TMD NBD Domaine régulateur pastel... ), troubles respiratoires, infectieux ou alimentaires ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 17 | Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus) | ||
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Summary: of transporter activity. In addition, we directly measured the levels of transcripts of SpABCC1 and SpABCB1... efflux. SpABCB1 encodes an efflux transporter similar to p- gp, an extensively studied xenobiotic... of real-time q-pcr analysis of mrp (SpABCC1) and p-gp ... |
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Source: |
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Collection: Environmental Sciences and Ecology |
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| 18 | European Journal of Clinical Pharmacology manuscript No. (will be inserted by the editor) | ||
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Summary: the impact on indinavir pharmacokinetics of ABCB1 polymorphisms, a gene inserm-00384935,version1-17May2009... shown that the ABCB1 C3435T genotype affects the absorption constant of indi- navir whereas Verstuyft et... Kit (Qiagen, Courtaboeuf, France). ABCB1 ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 19 | Antimicrob Agents Chemother . Author manuscript Population pharmacokinetic-pharmacogenetic study of nevirapine in | ||
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Summary: of variability focusing on the , and ( genes.CYP2B6 CYP3A5 ABCB1 MDR1) 170 Cambodian HIV-infected patients were... >T CYP2B6 1459C>T ABCB1 represent 42.4 , 9.2 , 0 and 18 of the population, respectively.3435C... ( ). and ( , which endcodes for P-glycoprotein) are known to be highly polymorphic (1 ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 20 | Functional hot spots in human ATP-binding cassette transporter | ||
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Summary: . For example, transporters such as ABCB1 are expressed in many different cell types,32 whereas ABCA4... transporters An additional three variants in ABCB1 (P-glycopro- tein) were experimentally characterized... -glycoprotein ... |
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Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine ; Biotechnology |
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| 21 | Epilepsia, **(*):110, 2007 Blackwell Publishing, Inc. | ||
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Summary: of multidrug resis- tance in epilepsy with a polymorphism in the drug-transporter gene ABCB1. New England... transporter ABCB1 (P-glycoprotein) nucleotide binding domain 2, residues 1028-1271. The Walker A motif... : Background: Multidrug ... |
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Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco |
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Collection: Biology and Medicine ; Biotechnology |
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| 22 | Comparison of [11 C]-(R)-PK 11195 and [11 | ||
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Summary: pair selectively overexpressed ABCB1, ABCC1, or ABCG2. To be a substrate for a transporter, uptake... . The three pairs were (listed as parental and resistant, respectively): KB-3-1 and KB-8-5-11 (ABCB1, also... -resistant cell lines were additionally cultured in the following cytotoxic ... |
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Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 23 | STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines | ||
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Summary: ). In addition, the functional activity of drug efflux proteins including ABCB1 was measured as internal accumula... to Doxorubicin and exhibits clas- sical MDR phenotype with overexpression of ABCB1.10 The re- sistant phenotype... Hs01013989_m1), IFI27 (Assay ID Hs00271467_m1) and ... |
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Source: Uppsala Universitet, Department of Material Science, Signals and Systems Group |
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Collection: Engineering |
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| 24 | 368 VOLUME 86 NUMBER 4 | OCTOBER 2009 | www.nature.com/cpt STATE ART nature publishing group | ||
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Summary: -gp (ABCB1), ABCG2, and sev- eral transporters of the ABCC family, most of which are apically (blood... , ABCB1 has been most studied because it encodes P-glycoprotein ((P-gp) or multidrug resistance 1 (MDR1... to describe a drug transported by ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 25 | ANRS12154Pecan_NVP_v1_dernier enregistrement par Anne-Marie Population pharmacokinetic-pharmacogenetic study of1 | ||
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Summary: enregistrement par Anne-Marie glycoprotein efflux transporter (1). CYP3A5, CYP2B6 and ABCB1 (MDR1, which endcodes... with decreased transport function. Consequently10 homozygous CYP3A5 6986GG, CYP2B6 516TT or 1459TT and ABCB1 3435... focusing on the5 CYP2B6, CYP3A5 ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 26 | 236 nature genetics volume 24 march 2000 A gene expression database for the | ||
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Summary: on drugs that it can transport out of the cell8,15,2124. Because ABCB1 is expressed at significant levels... gene ABCB1 (formerly MDR1) had closely related drug-activity profiles. HCT-15, with one of the highest... levels of ... |
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Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University; Brown, Patrick O.- Department of Biochemistry, Stanford University |
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Collection: Biology and Medicine ; Biotechnology |
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| 27 | The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals | ||
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Summary: . hamnerorum ABC transporters agreed well with human ABCB1 and ABCC3 models (Figs. S3, S4 in the Supplementary... of mammalian ABCB1 in barrier tissues coupled with its function as a unidirectional transporter of a range... with human ... |
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Source: Sotka, Erik - Grice Marine Laboratory, College of Charleston |
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Collection: Environmental Sciences and Ecology |
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| 28 | Comparison of [11 C]-(R)-PK 11195 and [11 | ||
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Summary: pair selectively overexpressed ABCB1, ABCC1, or ABCG2. To be a substrate for a transporter, uptake... . The three pairs were (listed as parental and resistant, respectively): KB-3-1 and KB-8-5-11 (ABCB1, also... -resistant cell lines were additionally cultured in the following cytotoxic ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 29 | Drug metabolism in human and rat intestine: An in vitro approach | ||
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Summary: (submitted for publication) 139 Chapter 8 Coordinated regulation of drug metabolizing enzymes, transporters... of the intestine, are able to metabolize and transport endogenous and exogenous compounds [4-7]. Drug metabolism... and transporters in the intestinal tract Although the liver ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 30 | P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with | ||
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Summary: studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... found that dLop is selective for P-gp (ABCB1) among the 3 most common ABC transporters at the blood... brain barrier ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 31 | Coordinated regulation of drug metabolizing enzymes, transporters and nuclear receptors | ||
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Summary: UGT1A6 (4-fold), also mRNA expression of the transporters MDR1/ABCB1 (2.5-fold), MRP3/ABCC3 (4.3-fold... Chapter 8 Coordinated regulation of drug metabolizing enzymes, transporters and nuclear receptors... ;Chapter 8 156 Abstract The sensitivity of drug metabolizing ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 32 | Hormone Transport Ian D. Kerr, David J. Carrier and Jamie Twycross | ||
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Summary: postulated to be auxin transporters in plants, viz ABCB1, ABCB4 and ABCB19. Mutants in Atpgp1 (encoding ABCB1... expression patterns of ABCB1, B19 and B4 are also consistent with a role in root auxin transport, being... ... |
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Source: Twycross, Jamie - School of Computer Science, University of Nottingham |
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Collection: Computer Technologies and Information Sciences |
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| 33 | Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal | ||
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Summary: | efflux The efflux transporter P-glycoprotein (P-gp; encoded by ABCB1) blocks the entry of various... to elucidate the mechanism of transport by P-glycoprotein (ABCB1). J Biol Chem 281:2650126511. 15. Pfister JR... -glycoprotein (P-gp), a ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 34 | Summary and outlook H. Bart van den Berg van Saparoea and Arnold J.M. Driessen | ||
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Summary: fermentation in wine making, #12;80 and MDR1 (ABCB1 or P-glycoprotein), a human MDR protein. The presence... in the chemotherapeutic treatment of cancer, and this is based on MDR transporters that are related to and function... drugs. Before the genetic basis of the MDR phenotype in L. lactis was discovered, ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 35 | Oxidoreductase HepG2 Huh7 Hepatocytes | ||
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Summary: such genes as C/EBP, HNF4, CYP2D6, and ABCB1. In contrast, HepG2 and Huh7 cells were unchanged from the liver... hepatic transport across basolateral and canalicular domains of the plasma membrane1,3, and expression... and activity of drug metabolizing enzymes2, 5, 6. Despite these reports, the specific ... |
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Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 36 | UNIVERSIT PARIS.DIDEROT (Paris 7) COLE DOCTORALE : 393 | ||
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Summary: 'excrétion d'un nombre important de médicaments (Marzolini et al., 2003). Le gène ABCB1 codant pour la P... populations caucasiennes et la fréquence du variant C3435T du gène ABCB1 est de respectivement 80% et 50% dans... simulés sont ceux des exons 26 et 21 du gène ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 37 | Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal | ||
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Summary: | efflux The efflux transporter P-glycoprotein (P-gp; encoded by ABCB1) blocks the entry of various... to elucidate the mechanism of transport by P-glycoprotein (ABCB1). J Biol Chem 281:2650126511. 15. Pfister JR... -glycoprotein (P-gp), a ... |
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Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 38 | In vitro methods to study intestinal drug metabolism | ||
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Summary: transporters increase (MDR1 (Pgp/ABCB1) [17-19], MRP1 (ABCC1 [19]), OCTN2 [20]), decrease (BCRP (ABCG2 [21... compounds. Furthermore, the relevance of drug transporters in this process has been proven. Only a few... . Their applicability to study phase I-III ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 39 | ABC transporters ABC transporter architecture and regulatory roles of | ||
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Summary: /3), human peptide transporter; PDR5, yeast pleiotropic drug resistance transporter; P-gp (MDR1/ABCB1), human... -glycoprotein (P-gp/MDR1/ABCB1) activity. Irrespective of the direction of transport (uptake or excretion... ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 40 | 10.1177/0091270004269705ARTICLEKHARASCH ET ALEVALUATION OF CYP3A AND P-GLYCOPROTEIN ACTIVITIES USING ALFENTANIL AND FEXOFENADINEDRUG METABOLISM AND TRANSPORT Evaluation of First-Pass Cytochrome P4503A | ||
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Summary: exhib- its marked interindividual variability, owing to widely DRUG METABOLISM AND TRANSPORT J Clin... effect.7-10 P-glycoprotein (P-gp), the product of the MDR1 (ABCB1) gene, is an adenosine triphosphate... /10 mM formic acid (3:7), and transferred to autosampler vials. DRUG METABOLISM ... |
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Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 41 | Place du test de permutation dans les mod`eles non lineaires `a effets mixtes : application en | ||
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Summary: aussi ´et´e g´enotyp´es pour 5 polymorphismes : ABCB1 exon 26 et 21, CYP3A5*3, CYP3A5*6 et CYPA4*1B... polymorphismes simul´es sur un des param`eres du mod`ele sont inspir´es des exons 26 et 21 du g`ene ABCB1, soit... mixtes, SAEM, Tests, Permutations Pharmacokinetics studies the time course of a ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 42 | P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with | ||
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Summary: studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... found that dLop is selective for P-gp (ABCB1) among the 3 most common ABC transporters at the blood... brain barrier ... |
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Source: McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health |
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Collection: Biology and Medicine |
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| 43 | Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric Dimers | ||
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Summary: 1/ABCB1), chosen because it shares many of the same transport substrates as ABCG2. The third... were expressed at the plasma membrane and maintained drug transport activity. Expression of an ABCG2... experiments and were functional for drug ... |
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Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University |
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Collection: Biology and Medicine ; Chemistry |
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| 44 | COMPARATIVE MEDICINE LABORATORY ANIMAL FACILITIES | ||
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Summary: SUPERVISION DURING TRANSPORTATION AND STORED IMMEDIATELY IN A DEPARTMENT SAFE OR CONTROLLED DRUG CABINET... for CONTROLLED DRUG PROCUREMENT 1.0 Purpose This procedure provides instruction to anyone wishing to purchase... a whole bottle(s) of controlled drug under the CMLAF DEA license number 2.0 Scope This ... |
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Source: Krovi, Venkat - Department of Mechanical and Aerospace Engineering, State University of New York at Buffalo |
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Collection: Engineering |
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| 45 | The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome | ||
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Summary: the multidrug transporters due to their ability to pump out multiple therapeutic drugs, a major obstacle... from eggs is Sp-ABCB1 (SPU_001752, 27 exons spanning 32 kb of genomic DNA). This gene is one of 12 ABCB... genes present in the sea urchin and is orthologous to mammalian ... |
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Source: |
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Collection: Environmental Sciences and Ecology |
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| 46 | Circadian Timing in Cancer Treatments | ||
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Summary: 3A4 UGT1A1 DPYD GSH ABCB1 ABCC2 ABCG2 Metabolism and detoxification Drug metabolism and target Drug... ) determines the optimal circadian timing of anticancer medications (bottom). The CTS controls drug transport... family members, including ... |
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Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt |
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Collection: Biology and Medicine |
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| 47 | Aquatic Animal Drug Approval Partnership: In Pursuit of Aquaculture Drug Approvals Legal and Judicious | ||
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Summary: animals treated with the drug Permits the legal interstate transport of the drug Aquatic Animal Drug... Aquatic Animal Drug Approval Partnership: In Pursuit of Aquaculture Drug Approvals Legal... and Judicious Use of Drugs and Therapeutants in ... |
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Source: Southern Illinois University, Fisheries and Illinois Aquaculture Center |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 48 | Bivalent Probes of the Human Multidrug Transporter P-Glycoprotein Marcos M. Pires, Christine A. Hrycyna,* and Jean Chmielewski* | ||
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Summary: of transport. In addition to acting as probes of P-gp's drug binding sites, these agents were also potent... -binding cassette) transporters. P-gp uses the energy of ATP hydrolysis to pump drug molecules out of cells so... are essential for the proper function- ing of P-glycoprotein, including ... |
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Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University |
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Collection: Biology and Medicine ; Chemistry |
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| 49 | This journal is c The Royal Society of Chemistry 2011 Mol. BioSyst. Cite this: DOI: 10.1039/c0mb00326c | ||
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Summary: .8 Glucosidase (predicted) pmd1 ABCB1 (P-glycoprotein 1) Resistant 100.4 ABC transporter family ura3 DHODH... ,26 To identify nonspecific drug efflux pumps, we examined the effects of a series of ABC transporter deletion... relatively Table 1 The MIC values against ABC ... |
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Source: Boone, Charlie - Department of Molecular and Medical Genetics, University of Toronto |
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Collection: Biotechnology |
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| 50 | Oxford University Press 2005 1 Discovering drug interactions: a text-mining and reasoning ap- | ||
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Summary: or cellular efflux of drugs. Transporters play an important role in drug disposition as drugs can only... be metabolized after they are transported into the liver cells. However, transporter-based drug interactions... expand our approach to in- ... |
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Source: Baral, Chitta - Department of Computer Science and Engineering, Arizona State University |
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Collection: Computer Technologies and Information Sciences |
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| 51 | nAture methods | VOL.8 NO.2 | FEBRUARY2011 | 159 Phenotypes that might otherwise reveal a gene's function | ||
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Summary: , I., Kroetz, D.L. & Rine, J. Function-altering SNPs in the human multidrug transporter gene ABCB1... - ceuticals. For example, ATP-binding cassette (ABC) transporters overlap in the drugs they export. To isolate... for characterizing exogenous transporters7. ... |
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Source: Harvard University, Center for Cancer Systems Biology; Roth, Frederick - Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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Collection: Biology and Medicine ; Biotechnology |
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| 52 | For personal use. Only reproduce with permission from The Lancet Publishing Group. MECHANISMS OF DISEASE | ||
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Summary: for two members of the superfamily of ATP- binding-cassette transporters (ABCB1 and ABCC4) were recorded... BMP7 RARG SPRY1 CEP2 GUCY1A3 MYO6 ABCC4 PCAF Protein kinase C KIT SPRY4 INPP5a PTP4A3 ABCB1 DNCI1... type 4A 3 RAB3a RAS-associated protein RAB3A ... |
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Source: Botstein, David - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University; Sherlock, Gavin - Department of Genetics, Stanford University; Utah, University of - Scientific Computing and Imaging Institute |
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Collection: Biology and Medicine ; Computer Technologies and Information Sciences |
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| 53 | 10.1177/0091270003262075ARTICLEKHARASCH ET ALFENTANYL AND P-GLYCOPROTEINDRUG METABOLISM Quinidine as a Probe for the Role of | ||
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Summary: G, et al: Effects of ABCB1 (multidrug resistance transporter) gene muta- tions on disposition... of intestinal epithelial cells, where it ac- tively transports drugs back into the gut lumen and limits... transports several bioactive amines and nitrogen-containing ... |
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Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 54 | tel-00628629,version1-3Oct2011 tel-00628629,version1-3Oct2011 | ||
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Summary: 'enzyme de désactivation UGT1A1, et les quatre transporteurs ABCB1, ABCC1, ABCC2, ABCG2. Au contraire, l... le transport du CPT11. Après synchronisation des cellules par choc sérique, qui définit le temps cir... -FU : 5-Fluorouracil ABC transporter : ATP-Binding Cassette transporter ... |
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Source: Paris-Sud XI, Université de - Institut d'Optique, Laboratoire Charles-Fabry, Groupe d'Optique Atomique |
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Collection: Physics |
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| 55 | Multidrug and peptide export in Lactococcus lactis | ||
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Summary: transporter ABCB1 (P-glycoprotein or MDR1) is a full- transporter in which a single polypeptide encompasses... transporters and when aligned with both the N- and C-terminal halves of the human ABCB1, approximately one... define the function of ... |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 56 | Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression | ||
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Summary: transport has primarily been associated with P-glycoprotein (ABCB1), Breast Cancer Resistance Protein (BCRP... regions of transporter genes contribute to observed variation in drug response. A total of 579... for the transport of drugs and other ... |
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Source: |
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Collection: Biology and Medicine ; Biotechnology |
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| 57 | Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues | ||
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Summary: , as transporters, such as P-glycoprotein (ABCB1), the bile salt export pump (ABCB11), multidrug resistance... , representing such genes as C/EBP, HNF4, CYP2D6, and ABCB1. In contrast, HepG2 and Huh7 cells were unchanged... of the hepatoma cell lines that were subjected to analysis (Fig. ... |
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Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 58 | This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the | ||
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Summary: results support these findings, as transporters, such as P-glycoprotein (ABCB1), the bile salt export pump... -represented categories, representing such genes as C/EBP, HNF4, CYP2D6, and ABCB1. In contrast, HepG2 and Huh7 cells were... , 203924_at; GPX1, 200736_s_at; ... |
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Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 59 | 14 Bushan, M. et al. (2002) Anti-E-selectin is ineffective in the treatment of psoriasis: a randomized trial. Br. J. Dermatol. 146, 824831 | ||
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Summary: , genes involved in drug transport [e.g. polymorphisms in the gene encoding P-glycoprotein 1 (ABCB1... ) Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409, 202207 9 Communi, D... .A. and Simon, J. (2001) An elusive receptor is finally caught: P2Y12, ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 60 | In Silico Prediction of Drug Transport Across Physiological Barriers | ||
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Summary: In Silico Prediction of Drug Transport Across Physiological Barriers Inauguraldissertation zur... , and active drug transport by the ATP binding cassette (ABC) transporter MRP2. In addition, a nature inspired... could be related to an active drug ... |
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Source: Amrhein, Valentin - Zoologisches Institut, Universität Basel |
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Collection: Environmental Sciences and Ecology |
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| 61 | Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes | ||
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Summary: . Few reports on the involvement of drug transporters in methadone disposition are available beyond... current results, studies on the effects of other drug transporters on methadone disposition appear... one-to-one by metabolite formation. This result does not exclude drug ... |
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|
Source: Omiecinski, Curtis - Department of Veterinary and Biomedical Sciences, Pennsylvania State University |
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Collection: Biology and Medicine |
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| 62 | UNIVERSIT PARIS XI FACULT DE PHARMACIE DE CHTENAY-MALABRY | ||
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Summary: Lopinavir LTC4 Leucotriène C4 LTR « Long terminal repeat » MCT « Monocarboxylate transporter » MDR... du système de transport d'efflux de la BHE tel-00364246,version1-25Feb2009 #12;11 Liste des tableaux |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 63 | Phenotype-Based Screening of Mechanistically Annotated Compounds in Combination with Gene Expression and Pathway | ||
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Summary: , of doxorubicin once a month and overexpresses Pgp/MDR1/ABCB1.11 The 8226/LR5 subline was exposed to 1.53 µg... Expression and Pathway Analysis Identifies Candidate Drug Targets in a Human Squamous Carcinoma Cell Model... of squamous cell carcinoma. (Journal of Biomolecular Screening 2006:457-468) Key words: ... |
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|
Source: Uppsala Universitet, Department of Material Science, Signals and Systems Group |
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Collection: Engineering |
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| 64 | Chemistry and Physics of Lipids 141 (2006) 119132 Proteins involved in lipid translocation in eukaryotic cells | ||
|
Summary: (2003) -idem ABCA1 PS, chol. Yes Hamon et al. (2000) Mice erythrocytes ABCB1 P-glycoprotein (MDR1) Low... in eukaryotes has been generally assigned to ATPases from the ABC superfamily of proteins such as ABCB1 commonly... a floppase activity in epithelial cells expressing MDR1or MDR3 (now named, ... |
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|
Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques |
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Collection: Chemistry ; Biology and Medicine |
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| 65 | Concluding Remarks and Perspectives 8.1. Concluding remarks | ||
|
Summary: phase in the drug-rich layer, C is crystallised drug, D is the stagnant layer transporting the drug via... , the dissolution of the matrix as measured during the experiment has to be used to calculate the drug transport... from the solid dispersion to the ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 66 | Summary and concluding remarks Microorganisms have developed multiple strategies to resist the | ||
|
Summary: ) active extrusion of drugs by transport proteins present in the cell membrane (Fig. 1). LmrP is one... of such transporters that extrude a wide variety of cationic drugs. It consists of 408 amino acids organized in 12... of drug target (T); C, prevention of drug ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 67 | ForPeerReview Expression, localization, and inducibility by bile acids of hepatobiliary transporters in | ||
|
Summary: ) for the efflux pumps Mdr1b/Abcb1b, Mdr2/Abcb4, Mrp1/Abcc1, Mrp2/Abcc2, Mrp3/Abcc3, Abcg5, Abcg8. This profile... reasons. Firstly, whereas most in vivo experiments on bile transport and biliary elimination of drugs... expression of drug transporters and its role in ... |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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|
Collection: Mathematics |
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| 68 | Systematic exploration of synergistic drug pairs Murat Cokol1,2, | ||
|
Summary: Systematic exploration of synergistic drug pairs Murat Cokol1,2, *, Hon Nian Chua1,3 , Murat Tasan1... 5545; E-mail: fritz.roth@utoronto.edu Received 13.7.11; accepted 11.8.11 Drug synergy allows... a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when ... |
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|
Source: Roth, Frederick - Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
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|
Collection: Biotechnology ; Biology and Medicine |
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| 69 | Advanced Drug Delivery Reviews 48 (2001) 137138 www.elsevier.com/locate/drugdeliv | ||
|
Summary: with the mathematical treatment of drug triggered transport (swelling) and degradation/ero- transfer through mucus... Advanced Drug Delivery Reviews 48 (2001) 137138 www.elsevier.com/locate/drugdeliv Preface... Mathematical modeling of controlled drug delivery Mathematical modeling of controlled ... |
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|
Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin |
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Collection: Biology and Medicine ; Materials Science |
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| 70 | ORIGINAL ARTICLE Global variation in CYP2C8CYP2C9 functional | ||
|
Summary: , and ABCB1 polymorphisms with the pharmacokinetics of paclitaxel. Clin Cancer Res 2005; 11: 80978104. 12... and drug transporters in chemotherapy. Methods Mol Biol 2008; 448: 6376. 27 Daly AK. Pharmacogenetics... - nomic implications for drug interactions. The Pharmacogenomics Journal ... |
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|
Source: Kidd, Kenneth - Department of Genetics, Yale University |
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Collection: Biology and Medicine |
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| 71 | A survey of integral a-helical membrane proteins Libusha Kelly Ursula Pieper Narayanan Eswar | ||
|
Summary: as in the human transporters ABCB1, ABCB11 and ABCB4 (Supplemen- tary Fig. 2). The most similar structurally... the rationale for their inclusion into the target list. In humans, ABCB1 (also known as MDR1) and other members... and families of particular interest, such as the diversity of ... |
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|
Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco |
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|
Collection: Biology and Medicine ; Biotechnology |
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| 72 | Expression Analysis of ABC Transporters Reveals Differential Functions of Tandemly Duplicated Genes in | ||
|
Summary: for cystic fibrosis.6 Some ABC proteins, such as MDR1 (ABCB1), MRP1 (ABCC1) and BCRP (ABCG2), are commonly... ., Kohno, K. & Wada, M. (1999). Multidrug resistance-associ- ated protein subfamily transporters and drug... Expression Analysis of ABC Transporters Reveals Differential ... |
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|
Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University |
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|
Collection: Biology and Medicine |
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| 73 | Regulating the Pharmaceutical IndustryRegulating the Pharmaceutical Industry The Wharton School | ||
|
Summary: statute which prohibits transport offederal statute which prohibits transport of unapproved drugs... the Pharmaceutical Industry History, Pricing, Drug Pipeline, Blockbuster Drugs, Legislative Trends, Federal Courts... History, Pricing, Drug Pipeline, Blockbuster ... |
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|
Source: Schutt, Clarence E.- Departments of Chemistry & Molecular Biology, Princeton University |
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|
Collection: Chemistry ; Biology and Medicine |
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| 74 | Abstract. The typically distinct phospholipid composi-tion of the two leaflets of a membrane bilayer is generated | ||
|
Summary: transporter ABCB1 translocated a wide variety of short chain lipids [110113], including the short chain PC... that transport a broad range of substrates, includ- ing ions, sugars, drugs and peptides across cellular mem... platelet-activat- ing factor [114, 115]. The ... |
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|
Source: Menon, Anant K. - Menon Lab, Weill Medical College, Cornell University |
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Collection: Biology and Medicine |
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| 75 | Pharmaceutical Chemistry B.S. 1. General description and characteristics of the program. | ||
|
Summary: emphasizes the chemistry of drug design and development, drug action, drug transport, drug delivery... of biological processes and mechanisms of drug action. Progress in the field now depends on the design... , and computer-aided drug design. In ... |
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|
Source: Michigan Technological University, School of Forest Resources and Environmental Science, Aspen FACE (Free-Air Carbon Dioxide Enrichment) Experiment |
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|
Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 76 | Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells | ||
|
Summary: of the amplified MDR1 (ABCB1) gene in drug- resistant variants of a human sarcoma. Genes Chromosomes Cancer 2002... Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells... - taneously resistant against cytotoxic drugs at rates of up to 1023 per ... |
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|
Source: Duesberg, Peter - Department of Molecular and Cell Biology, University of California at Berkeley |
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|
Collection: Biology and Medicine |
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| 77 | DOI: 10.1126/science.1167625 , 1714 (2009);323Science | ||
|
Summary: -facing conformation represents an initial stage of the transport cycle that is competent for drug binding. T he... three molecular "pumps" that actively transport drugs out of the cell (3). The most prevalent... because of its clinical relevance. We describe the structure of mouse P-gp ... |
|||
|
Source: Martin, Ellen - Department of Geological Sciences, University of Florida |
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|
Collection: Geosciences |
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| 78 | Press Release Corporate Communications | ||
|
Summary: .ch@pvw.tu-darmstadt.de www.tu-darmstadt.de/presse presse@tu-darmstadt.de New Substances Accelerate Drug Transport Into Cells... for speeding the transport of the active ingredients of drugs into live cells that might allow drastically... transport drugs faster In an ... |
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|
Source: Hoffmann, Rolf - Fachbereich Informatik, Technische Universität Darmstadt |
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|
Collection: Computer Technologies and Information Sciences |
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| 79 | Personalized Medicine: Marking a New Epoch in Cancer Patient Management | ||
|
Summary: subgroups of cancer patients. Variations in genes that encode drug-metabolizing enzymes, drug transporters... to identify unique molecular targets for drug design. Such strategies will reduce the cost of lead discovery... , reduce the timeline and costs of clinical trials, and potentially revive ... |
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|
Source: |
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Collection: Biotechnology ; Biology and Medicine |
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| 80 | A mechanistic model of controlled drug release from polymer millirods: Effects of excipients and complex binding | ||
|
Summary: with these devices have examined the control of drug release [3,4] and drug transport in tissues [3... incorporates the essential transport and kinetic processes underlying the drug release from the polymeric... A mechanistic model of controlled drug release from ... |
|||
|
Source: Gao, Jinming - Department of Oncology and Pharmacology, University of Texas Southwestern Medical Center at Dallas |
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|
Collection: Biology and Medicine |
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| 81 | Solid dispersions offer a drug delivery platform that may overcome problems related to the absorption of poorly water-soluble drugs in-vivo. This is ascribed to | ||
|
Summary: dissolution rate was reached: the transport of dissolved drug to the drug-rich layer was balanced... 149 Chapter 9 Summary Solid dispersions offer a drug delivery platform that may overcome problems... related to the absorption of poorly water-soluble drugs in-vivo. This is ascribed to ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 82 | List of publications Full papers | ||
|
Summary: IAM, Ungell ALB, Groothuis GMM: Coordinated regulation of drug metabolizing enzymes, transporters... precision-cut slices, 1 st Eufeps conference on drug transporters, Barcelona, Spain, April 2005 4. Van de... , De Graaf IAM, De Jager MH, Groothuis GMM: Induction of drug metabolising ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 83 | MISSISSIPPI STATE UNIVERSITY DRUG AND ALCOHOL FREE WORKPLACE POLICY | ||
|
Summary: MISSISSIPPI STATE UNIVERSITY DRUG AND ALCOHOL FREE WORKPLACE POLICY INTRODUCTION AND PURPOSE... Mississippi State University implements this drug and alcohol policy and conducts a testing program pursuant... to Sections 71-7-1, et seq., of the Mississippi Code of 1972, Ann., entitled "Drug and Alcohol Testing |
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|
Source: Mississippi State University, Center for Advanced Vehicular Systems (CAVS) |
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|
Collection: Engineering |
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| 84 | Revision of existing Code. Approved October 2009. | ||
|
Summary: hazardous substances or transportable gases if affected by drugs. 3.5 The Occupational Health Unit... WCP1 Drugs Revision of existing Code. Approved October 2009. 1 Health and Safety Unit Health... and Safety Codes of Practice Welfare Code Drugs #12;WCP1 Drugs Revision of existing Code. ... |
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|
Source: Brown, Richard - School of Biological and Earth Sciences, Liverpool John Moores University |
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|
Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 85 | 836 Current Drug Metabolism, 2009, 10, 836-841 1389-2002/09 $55.00+.00 2009 Bentham Science Publishers Ltd. | ||
|
Summary: the drugs into the extracellular space. Therefore, overexpression of multidrug transporters enables a rapid... mechanisms that are due to multidrug transporters such as P-gp. In MDR cells, transmembrane drug-efflux pumps... 836 Current Drug Metabolism, 2009, 10, 836-841 1389-2002/09 ... |
|||
|
Source: Zhang, Liangfang - Department of Nanoengineering, University of California at San Diego |
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|
Collection: Materials Science |
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| 86 | European Journal of Pharmaceutical Sciences 9 (1999) 3340 www.elsevier.nl/locate/ejps | ||
|
Summary: Published by Elsevier Science B.V. All rights reserved. Keywords: Drug transport; Swelling; Polymer... . In fact, solid drug transport has been already observed and de- scribed by Colombo et al. (1997... of a significant polymer transport, often associated with chain relaxation, which ... |
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|
Source: Peppas, Nicholas A. - Departments of Biomedical Engineering & Chemical Engineering, University of Texas at Austin |
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|
Collection: Biology and Medicine ; Materials Science |
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| 87 | Genome Biology 2007, 8:R131 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation | ||
|
Summary: , KL), corticosteroid/daunorubicin transport (ABCB1), modification of cholesterol (ABCB1, SULT2B1... ), transport of fludarabine (SLC28A2), hydrocortisone uptake (ABCB1), formation of aberrant crypt foci (NR5A2... ), ... |
|||
|
Source: Dove, William - McArdle Laboratory for Cancer & Department of Medical Genetics, University of Wisconsin at Madison |
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|
Collection: Biology and Medicine |
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| 88 | Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 Is Required for Polar Auxin Transport C W | ||
|
Summary: -1, aux1-7, and abcb1. Each of these mutants is affected in gravitropism due to a defect in auxin... plants (Oono et al., 1998; Gray et al., 2001). The axr2-1, abcb1/ pgp1, and aux1-7 mutants have been... 7 (at3g23050), ABCB1/PGP1 (at2g36910), PIN1 (at1g73590), PIN2 ... |
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|
Source: Prigge, Michael J. - Division of Biological Sciences, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 89 | Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 Is Required for Polar Auxin Transport C W | ||
|
Summary: -1, aux1-7, and abcb1. Each of these mutants is affected in gravitropism due to a defect in auxin... plants (Oono et al., 1998; Gray et al., 2001). The axr2-1, abcb1/ pgp1, and aux1-7 mutants have been... 7 (at3g23050), ABCB1/PGP1 (at2g36910), PIN1 (at1g73590), PIN2 ... |
|||
|
Source: Estelle, Mark - Division of Biological Sciences, University of California at San Diego |
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|
Collection: Biology and Medicine |
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| 90 | Rehabilitation Program for Alcohol and Drug Abuse revised 05/20/09 #751 Page 1 of 2 | ||
|
Summary: Rehabilitation Program for Alcohol and Drug Abuse revised 05/20/09 #751 Page 1 of 2... Rehabilitation Program for Alcohol and Drug Abuse Texas A&M University is committed to protecting the health... and safety of its employees. Because alcohol and drug abuse is a significant problem in the United States |
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|
Source: Texas A&M University, Spatial Sciences Laboratory |
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|
Collection: Geosciences |
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| 91 | Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics | ||
|
Summary: * and Mary V. Relling Genetic polymorphisms in drug-metabolizing enzymes, transporters, re- ceptors... - morphisms of drug-metabolizing enzymes are so common. Genetic Polymorphisms in Drug Transporters Although... and elimination, the clinical rele- vance of polymorphisms in ... |
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|
Source: Hahn, Mark E. - Biology Department, Woods Hole Oceanographic Institution |
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|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 92 | Introduction: Production, stability, and dissolution of solid dispersions to improve | ||
|
Summary: by the dissolution of the drug and the subsequent transport over the intestinal membrane and passage of the liver... -I drugs dissolve rapidly in an aqueous environment and are rapidly transported over the absorbing membrane... depends on the transport mechanism over the membrane. When ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 93 | As a recipient of federal funds, Georgia Southern University supports and complies with the provisions of the Drug Free Schools and Communities Act Amendments of 1989 and the Drug Free Workplace Act of 1988. In | ||
|
Summary: with the provisions of the Drug Free Schools and Communities Act Amendments of 1989 and the Drug Free Workplace Act... possession, use, or distribution of illicit drugs and alcohol by students and employees. To comply... possession, manufacture, distribution, dispensation, or use of illicit drugs and alcohol ... |
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|
Source: Hutcheon, James M. - Department of Biology, Georgia Southern University |
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|
Collection: Environmental Sciences and Ecology |
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| 94 | Project: In silico Modelling of Drug-Membrane Interactions: Predicting Non Specific Binding The Chemical Biology (http://www.chemicalbiology.ac.uk/) Doctoral Training Centre is inviting | ||
|
Summary: you will test novel experimental theories on drug transport proposed at Imperial and GSK plc... Project: In silico Modelling of Drug-Membrane Interactions: Predicting Non Specific Binding... the behavior of drug molecules in vivo. A deeper understanding of the molecular basis of non specific binding |
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|
Source: Rosso, Lula - Department of Chemistry, Imperial College, London |
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Collection: Chemistry ; Biology and Medicine |
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| 95 | Seminars in Immunology 15 (2003) 257270 Chemokine regulation of naive T cell traffic in health and disease | ||
|
Summary: transporter Abcb1 (MDR-1, P-glycoprotein) and the leukotriene C4 transporter Abcc1 (MRP-1 [95]). Blocking... either of these channels with pharmacologic in- hibitors or using T cells from Abcb1 or Abcc1-deficient... leukotrienes. Thus, a model of sequential ... |
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|
Source: von Andrian, Ulrich H. - Immune Disease Institute & Department of Pathology, Harvard University |
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|
Collection: Biology and Medicine |
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| 96 | 323ISSN 2041-599010.4155/TDE.10.13 2010 Future Science Ltd Therapeutic Delivery (2010) 1(2), 323334 Special FocuS: oncology | ||
|
Summary: therapeutics in the last two decades. Advances in biocompatible nanoscale drug carriers such as liposomes... and polymeric nanparticles have enabled more effi- cient and safer delivery of a myriad of drugs. Advantages... in nanoparticle drug delivery, par- ticularly at the systemic level, include longer cir- culation half |
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|
Source: Zhang, Liangfang - Department of Nanoengineering, University of California at San Diego |
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|
Collection: Materials Science |
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| 97 | This Provisional PDF corresponds to the article as it appeared upon acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon. | ||
|
Summary: drug targets based on simple sequence properties BMC Bioinformatics 2007, 8:353 doi:10... drug targets based on simple sequence properties Qingliang Li1, 2 and Luhua Lai1, 2* 1 Beijing National... , research and development in drug discovery have attracted much attention and efforts. However, only 324 |
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|
Source: Luhua, Lai - Institute of Physical Chemistry, Peking University |
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|
Collection: Chemistry ; Biotechnology |
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| 98 | Annu. Rev. Ecol. Evol. Syst. 2005. 36:16989 doi: 10.1146/annurev.ecolsys.36.102003.152617 | ||
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Summary: of elimination processes such as enzymes, transporters, and renal excretion. The elimination of probe drugs... transporters. Drug Metab. Rev. 36:595615 Boyle R. 2000. Metabolic fate of dietary ter- penes in folivorous... of PSMs across intestinal cells can be regulated by two molecular mechanisms, a glyco- ... |
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|
Source: Foley, Bill - School of Botany and Zoology, Australian National University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 99 | 3 MAY 2002 VOL 296 SCIENCE www.sciencemag.org838 The cell membrane has a tough job. A mere | ||
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Summary: excluding others. Already, one drug designed to take advantage of a specific transport mechanism has reached... , charge, or chemical composition. Hijacking a transporter seems a promis- ing way to get a drug across... . Chemists at drug company Roche used the same approach to make ... |
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|
Source: Akhmedov, Azer - Department of Mathematics, University of California at Santa Barbara |
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|
Collection: Mathematics |
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| 100 | Nederlandse samenvatting De bestrijding van infectieziekten met behulp van antibiotica (hier | ||
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Summary: om informatie te verkrijgen omtrent de functie van deze bacteriële MDR-transporter. Het aantal drugs... energie nodig voor het transport van positief geladen drugs geleverd kan worden door een electrische... plaats vindt is echter nog niet opgehelderd. Het transport van de ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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