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Sample search results for: a1 adenosinergic agonist

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1 Adenosine does not save the heart of anoxia-tolerant vertebrates during prolonged oxygen deprivation
 

Summary:  interaction with at least four (i.e., A1, A2A, A2B and A3) cell membrane receptors (Newby, 1984; Newby et al... during periods of oxygen deprivation in anoxia-intolerant mammals, the importance of adenosinergic... cardiovascular control in anoxia-tolerant vertebrates is poorly understood. Here, we report on ...

  

Source: Farrell, Anthony P. - Faculty of Land and Food Systems, University of British Columbia

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
2 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system after chronic A1 receptor
 

Summary:  of the adenosine A1 receptor agonist N6 -cyclopentyladenosine (CPA) not only desensitizes the adenosine receptors... - desensitization of the response. In conclusion, the present study shows that chronic application of the A1 agonist... .c.) injections of the potent ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
3 103:1937-1953, 2010. First published Jan 27, 2010; doi:10.1152/jn.00795.2009J Neurophysiol Cecilia G. Diniz Behn and Victoria Booth
 

Summary:  into these areas promotes sleep (Basheer et al. 1999; Van Dort et al. 2009), and microinjection of adenosine A1... of microinjections of neurotransmitter agonists and antago- nists into a key wake-promoting population, the locus... with experimental observations. Agonist/antago- nist pairs, which are ...

  

Source: Kopell, Nancy - Center for BioDynamics, Boston University

 

Collection: Biology and Medicine

 
4 Nederlandse samenvatting NEDERLANDSE SAMENVATTING
 

Summary:  . Bijvoorbeeld de serotonine-1A en de adenosine A1 receptoren worden aan dezelfde G-eiwitten gekoppeld. In het... met de serotonine-1A agonist 8- OH-DPAT veranderde niet door de chronische adenosinerge behandeling... systeem aan de hand van het fysiologische verschijnsel dat het inspuiten van de 1A receptor ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
5 General discussion 1. Neurobiological consequences of chronic partial sleep deprivation
 

Summary:  desensitization of the adenosine A1 receptor system, but did not result in a desensitized serotonin-1A signalling... in response to an injection of the serotonin-1A receptor agonist 8-OH-DPAT, that is, body temperature... receptor agonist oxotremorine-induced 95 #12;Chapter 9 hypothermic response as read-out ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
6 PharmacologyBiochemistry&Behavior,Vol. 39, pp. 97-103. PergamonPressplc, 1991.Printedin the U.S.A. 0091-3057/91 $3.00 + .00 Behavioral Effects of Intrastriatal
 

Summary:  .S.A. 0091-3057/91 $3.00 + .00 Behavioral Effects of Intrastriatal Caffeine Mediated by Adenosinergic... . Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine. PHARMACOL... - gests possible involvement of adenosinergic and/or dopaminergic (DA) systems. To evaluate

  

Source: Beninger, Richard J. - Department of Psychology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
7 The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays
 

Summary:  modelling and virtual screening assays Michael Schneider a,1 , Steffen Wolf a,b , Jürgen Schlitter a , Klaus... The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology... and inverse agonists in structure-based computational ligand screening. Using the b2- adrenergic ...

  

Source: Gerwert, Klaus - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
8 Brain Research, 589(1992)55-61 1992Elsevier Science PublishersB.V. All rightsreserved0006-8993/92/$05.00
 

Summary:  ) receptor sub- types into the ventral striatum (nucleus accumbens) led to locomotor activation ~'a-1°'~a... unilateral intrastriatai microinjectionsof the agonist, N-methyI-D-aspartate(NMDA) or the antagonist, 2-amino... directionas that seen followingsimilarunilateral injectionsof locomotion-stimulatingDA ...

  

Source: Beninger, Richard J. - Department of Psychology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
9 ADENOSINE, PROLONGED WAKEFULNESS, AND A1-ACTIVATED NF-UB DNA BINDING IN THE BASAL FOREBRAIN OF THE RAT
 

Summary:  of the highly selective A1 adenosine receptor agonist, N6 -cyclopentyladenosine (Benington et al., 1995... shown that increased agonist levels and/or stimulation of larger number of A1 adenosine receptor... .A., Strecker, R.E., McCarley, R.W., 1999. ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
10 Special issue: Allosterism and Collateral Efficacy Conformational complexity of
 

Summary:  histamine receptor [20], the a1b adrenoceptor [21,22] and the angiotensin (AT1) receptor [23]. My co... . Pharmacol. 57, 890­898 21 Scheer, A. et al. (1996) Constitutively active mutants of the a1B- adrenergic... Scheer, A. et al. (1997) The activation process of the ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
11 Progress in Neurobiology 66 (2002) 355474 Descending control of pain
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . 424 11.2.2.1. Antinociceptive actions mediated by A1 receptors... in its pain-relieving properties, while induction of analgesia by the adrenergic agonist, clonidine... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 376 5.9. Co-operative antinociceptive actions ...

  

Source: Meagher, Mary - Department of Psychology, Texas A&M University

 

Collection: Biology and Medicine

 
12 Development/Plasticity/Repair Spinal Adenosine A2a Receptor Activation Elicits Long-
 

Summary:  in re- sponse to neurotrophin binding. K252a (1.75 g kg 1 ; 150 M dis- solved in DMSO; Sigma... immature TrkB80 protein near phrenic motoneurons.a,AveragedatademonstratingthatintrathecalK252a(1.75 g kg 1... tyrosine kinases, the Trk receptors. Thus, we hypothesized that A2a receptor ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
13 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  P2X2/4/6/7 P2X2/4/6 P2X7 P2X7 P2X4 P2Y6 P2Y1 P2Y12 IL-1 P2X4 P2X3 P1 P1(A1)­ ­ ­ ­ + Presynaptic... inhibitory modulator through P1(A1 ) receptors, but ATP itself can act presynaptically either to inhibit... 1 (adenosine) A1 Brain, spinal cord, testis, heart, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
14 Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
 

Summary:  -Whitney test.) (D­F). The A1 agonist CCPA (500 nM) reduces fEPSP in wild-type mice (12 slices, five animals... -suppressing effects of the A1 receptor antagonist CPT were prevented following inhibition of gliotransmission... a pathway involving ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
15 Sleep Deprivation and Vigilant Attention JULIAN LIM a,b
 

Summary:  - and extracellular adeno- sine in the basal forebrain.90­92 An in vivo PET study of the adenosine A(1) receptor... A(2A), and not A(1) subtype receptor sites.109 As discussed, the accu- mulation of adenosine... homeostatic sleep drive after 12 h of wake- fulness. Moreover, the administration of an adenosine ...

  

Source: Pennsylvania, University of - Center for Cognitive Neuroscience, Unit for Experimental Psychiatry

 

Collection: Biology and Medicine

 
16 Sleep Deprivation and Vigilant Attention JULIAN LIM a,b
 

Summary:  - and extracellular adeno- sine in the basal forebrain.90­92 An in vivo PET study of the adenosine A(1) receptor... A(2A), and not A(1) subtype receptor sites.109 As discussed, the accu- mulation of adenosine... homeostatic sleep drive after 12 h of wake- fulness. Moreover, the administration of an adenosine ...

  

Source: Pennsylvania, University of - Center for Cognitive Neuroscience, Unit for Experimental Psychiatry

 

Collection: Biology and Medicine

 
17 The American Journal of Physiology, Renal Physiology --Manuscript F-00256-2007 --
 

Summary:  to A1-adenosine receptor (A1AR) -agonist cyclohexyl-adenosine (CHA). Time course of the response... mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice... autoregulation and the role of ...

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
18 ATP signalling in epilepsy Ashwin Kumaria & Christos M. Tolias &
 

Summary:  studies have confirmed such a role and attributed A1 receptor activation to the observed antiepileptic... hippocampal region have the opposite effect to A1 receptors in a piriform cortex kindling model. Adenosine... ) Adenosine acting via A1 receptors, controls the ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 Exp Brain Res (1995) 105:123-137 9 Springer-Verlag 1995 Lauren E. Sergio -David J. Ostry
 

Summary:  Gill University, 1205 Dr. Penfield Avenue, Montreal, Quebec, Canada H3A 1Bl; Fax no.: +1-514-3984896 Present... with respect to agonist burst magni- tude: those whose burst magnitude varied with motion in a second degree... that the magnitude of the agonist burst was greatest for movements in which a muscle ...

  

Source: Malfait, Nicole - Neurobiologie Intégrative et Adaptative, Université de Provence

 

Collection: Biology and Medicine

 
20 Kinship, Reproductive Strategies and Social Dynamics of Yellow-Bellied Marmots Author(s): Kenneth B. Armitage and Dennis W. Johns
 

Summary:  0 E 0 E Ylgy: Ylgy 5a 1.5 0 1.9 0 1.7 0 - - - - Ylgy:Ady oa 7.2 28a 9.0 29a 19.7 0 22a 12.3 3 4... ?:AdS 4a 1.4 0 0.7 X2= 25.2 x2 = 10.7 P<0.001 P<0.025 Yearling males behaved more amicably than ex- pected... 0 2.0 16a 4.1 2 0.6 1 0.4 5 2.6 oa 4.5 Ylgs: Ylgs 3a ...

  

Source: Blumstein, Daniel T. - Department of Ecology and Evolutionary Biology, University of California at Los Angeles

 

Collection: Environmental Sciences and Ecology


Page:   2  3  4  5 
Page:   1  2  3  4  5 
 
21 Adenosine-Mediated Presynaptic Modulation of Glutamatergic Transmission in the Laterodorsal Tegmentum
 

Summary:  the amplitude, and (3) inhibition of the evoked EPSC was mimicked by the A1 agonist N6-cyclohexyladenosine (100... agonist CHA (100 nM) for the selective activation of A1 receptors (EC50 1­2 nM at A1 receptors; EC50 450... ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
22 Binding, gating, anity and ecacy The nature of the problem
 

Summary:  for an ion channel as b1 and the shutting rate constant as a1, so E1=b1/a1. A mutant receptor in which both b... 1 and a1 were Binding, gating, affinity and efficacy928 D. Colquhoun #12;halved would have the same... nicotinic acetylcholine receptor Eect of dierent ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
23 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... as the therapeutic potential of purinergic agonists or antagonists for the treatment of supraventricular tachycardia... in rats and dogs by the P2Y receptor agonist adenosine-5'- (2-thiodiphosphate) has ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
24 Identification of an Allosteric Binding Site for Zn2 Adrenergic Receptor*
 

Summary:  have been identified for the A1 adenosine receptor. The 2-ami- no-3-benzoylthiophene, PD 81,723, has... muscarinic receptor (19), the A1 adenosine receptor (3), and the Ca2 -sensitive receptor (11). Binding... in Bmax1 mM Zn2 1 mM Zn2 nM WT 0.54 0.14 7.4 2.1 13.7 51 H269A ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
25 General introduction 1. Why do we sleep?
 

Summary:  interactions with other systems (muscarinic cholinergic and adenosinergic) are discussed in Chapters 2, 3, 5... receptor agonist and measuring body temperature responses with a radio telemetry set-up. We assessed how... to pharmacological challenges with a serotonergic agonist and corticotropin releasing hormone. Based on our ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
26 NEUROBIOLOGICAL AND FUNCTIONAL CONSEQUENCES OF CHRONIC PARTIAL SLEEP DEPRIVATION
 

Summary:  interactions with other systems (muscarinic cholinergic and adenosinergic) are discussed in Chapters 2, 3, 5... receptor agonist and measuring body temperature responses with a radio telemetry set-up. We assessed how... to pharmacological challenges with a serotonergic agonist and corticotropin releasing hormone. Based on our ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
27 Author'sProof Glucose oxidation is the principal source of energy for the
 

Summary:  extracellular potassium in conjunction with a bath application of the adenosine A1 receptor agonist cyclo... increased [K+ ]o to 10 mM in the presence of the A1 adenosine receptor agonist CPA (200 n... receptor agonist cyclo- pentyladenosine ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
28 General Pharmacology 32 (1999) 669681 Serotonin induces four pharmacologically separable contractile
 

Summary:  of solutions. (A) 1 mM 8-OH-DPAT; (B) 1 mM mCPP; (C) 1 mM DOI; (D) 100 M -Me- 2.2.8. 5-MeOT (5-HT4 agonist) 5... of the selective serotonin agonists ( )-8-hydroxy-2-(di-n-propylamino)tetralin, N-(3-trifluoromethylphenyl... of a large number of selective sero- 5-HT2, 5-HT5, 5-HT6, and 5-HT7 receptors existed ...

  

Source: O'Gara, Bruce A. - Department of Biological Sciences, Humboldt State University

 

Collection: Biology and Medicine

 
29 Serotonin is a biogenic amine that activates a large and heterogeneous family of receptors that are widely
 

Summary:  as determined in eqn (1). Recovery from desensitization was determined by the equation: Current(t) = A(1 _ exp... & Vijverberg, 1996). The rising phase of responses was fitted to the equation: Current(t) = A(1 _ exp... that the binding of at least three agonist molecules is required ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
30 Z .Brain Research 793 1998 244254 Research report
 

Summary:  agonist and 100 nM V antagonist alone for 60 min. A1 1a second set of cultures was pre-exposed to 100 nM V... of cortical neurons. Using a selective agonist for V vasopressin receptor, the data show that V1a1 vasopressin... accumulation by ...

  

Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California

 

Collection: Biology and Medicine

 
31 Allosteric Modulation of 2-Adrenergic Receptor by Zn2 GAYATHRI SWAMINATH, JACQUELINE STEENHUIS, BRIAN KOBILKA, and TAE WEON LEE
 

Summary:  , allosteric com- pounds have been identified for the A1 adenosine receptor. The 2-amino-3-benzoylthiophene PD... ) The allosteric enhancer, PD 81,723, stabilizes human A1 adenosine receptor coupling to G proteins. Biochim... 258:3913­3919. Musser B, Mudumbi RV, Liu J, Olson RD, and Vestal RE (1999) Adenosine ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
32 Exploring the Binding Site Structure of the PPAR Ligand-Binding Domain by Computational Solvent Mapping
 

Summary:  -propanol urea 1prg (a) 1 P3 1 (4.73) 1 (8.87) 1 (6.44) 1 (7.72) 1 (9.61) 1 (8.48) 3 (8.71) 5 (8.67) 2 (5... .91) 1 (3.20) 5 (4.39) 4 C2 4 (8.12) 5 (9.08) 5 B 4 (11.72) 5 (14.28) 4prg (a) 1 P3 5 (2.84) 3 (0.61) 1... methanol 2-propanol urea 2prg (a) 1 P1 2 (0.71) 3 ...

  

Source: Vajda, Sandor - Department of Biomedical Engineering, Boston University

 

Collection: Biotechnology ; Biology and Medicine

 
33 Brain Research 943 (2002) 117131 www.elsevier.com/locate/bres
 

Summary:  . Discussion absence of extracellular calcium. V agonist induced a1 3 significant rise in [ H]IP accumulation... . Antagonism of V agonist (V a)-stimulated Ca uptake by a1 1 signaling pathways leading to the expression... Res. 451a ...

  

Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California

 

Collection: Biology and Medicine

 
34 ENERGY DEPRIVATION TRANSIENTLY ENHANCES RHYTHMIC INHIBITORY EVENTS IN THE CA3 HIPPOCAMPAL NETWORK IN VITRO
 

Summary:  BG (2006) Sustained elevation of extracellular adenosine and activation of A1 receptors underlie... band and requires application of very high concentrations of agonists (Konopacki et al., 1987; Mac... that the group I metabotropic glutamate receptor agonist (S)-DHPG at low concentrations (~100 nM) induced

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
35 Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents
 

Summary:  -matched P-gp knockout (mdr-1a/1b(-/-)) (Schinkel et al., 1996) and wild type mice (mdr-1a/1b(+/+), 27... Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1... 2008; accepted 1 March 2008 Available online 18 March 2008 [11 C]MePPEP is an ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
36 Social Activity and the Antler Cycle In Red :peer Stags Research Institute oj Animal Production, Praha-UIiHnlves, Czechoslovakia
 

Summary:  . The effect on developing antlers. 1,,: A1Ilkr INvtlojJmmt i" CtrVidlu. R 0 Brown editor, Caesar Kleberg... Production, Praha-UIiHnlves, Czechoslovakia Abstract Analysis of the relationships between agonistic activity... was shown between agonistic behaviour and timing of velvet shedding. Keywords: antler ...

  

Source: Bartos, Ludek - Department of Ethology, Institute of Animal Science, Prague & Department of Animal Science and Ethology, Czech University of Life Sciences

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
37 Heterologous Expression of the Adenosine A1 Receptor in Transgenic Mouse Ning Li,, David Salom,, Li Zhang,,# Tim Harris,,4 Juan A. Ballesteros,,O Marcin Golczak, Beata Jastrzebska,
 

Summary:  Heterologous Expression of the Adenosine A1 Receptor in Transgenic Mouse Retina Ning Li,, David... show that the adenosine A1 receptor, when placed under the influence of the mouse opsin promoter... of glycosylation. Upon solubilization, the retinal adenosine A1 ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
38 Function and structure in glycine receptors and some of their relatives
 

Summary:  of the rat recombinant a1 homomeric glycine receptor as a function of the number of agonist molecules bound... of the human a1 subunit), and with 20­24% sequence identity with the extracellular domain of nicotinic sub... (anticlockwise) as ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
39 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Dec. 2010, p. 82558258 Vol. 76, No. 24 0099-2240/10/$12.00 doi:10.1128/AEM.00499-10
 

Summary:  to additional screening. We identified nine antagonists (X2 to X10) and 14 agonists (A1 to A14) of Las... A1 and the lack of an amide bond in A5. Overall, the identification of antagonists and agonists... ) and agonists ...

  

Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
40 A fluorophore attached to nicotinic acetylcholine receptor M2 detects productive binding of
 

Summary:  - somerization (a 1-ms flash 5 s after start of cis-BisQ perfusion) elicited a 765-nA current. Control traces... A fluorophore attached to nicotinic acetylcholine receptor M2 detects productive binding of agonist... . During agonist application, fluorescence increased by ( F F) 10%, and the emission peak ...

  

Source: Bezanilla, Francisco - Department of Biochemistry and Molecular Biology, University of Chicago; Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
41 T-Cell Activation: A Queuing Theory Analysis at Low Agonist Density J. R. Wedagedera* and N. J. Burroughsy
 

Summary:  )/ (1 ­ a) 1 kam /koff. Steady-state TCR densities are shown in Fig. 2 under differing levels of agonist... T-Cell Activation: A Queuing Theory Analysis at Low Agonist Density J. R. Wedagedera* and N. J... of thresholds and signal integration, a T cell can be responsive to low ligand density and specific to ...

  

Source: Wedagedera, Janak R. - Department of Mathematics, University of Ruhuna, Sri Lanka

 

Collection: Mathematics

 
42 T-cell triggering thresholds are modulated by the number of antigen within individual
 

Summary:  100x N.A.1.3 objective on CoolSnapHQ camera. Total internal reflection fluorescence (TIRF) was done... small numbers of activating agonist peptides. Spatial organization of T-cell receptors (TCR... -cell activation. Here we have designed an experimental strategy that enables control over the number of agonist

  

Source: Dustin, Michael - Skirball Institute of Biomolecular Medicine, New York University

 

Collection: Biology and Medicine

 
43 Modeling the Binding and Function of Metabotropic Glutamate Xavier Rovira, David Roche, Juan Serra, Julie Kniazeff, Jean-Philippe Pin, and Jess
 

Summary:  depending on the equilibrium constants included in the mechanism (see Equation A1 in the Appendix... according to the VFT binding model represented in Figure 1. As shown in the Appendix (Equation A1... cooperativity in agonist binding (Suzuki Y et al (2004) J Biol Chem 279:35526-35534) ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
44 Regulation of Adenylyl Cyclase Isozymes on Acute and Chronic Activation of Inhibitory Receptors
 

Summary:  (1987) Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system... is regulated by chronic exposure to inhibitory agonists and the nature of the adenylyl cyclase isozymes... above, on chronic treatment with agonists of several different inhibitory receptors, yet under ...

  

Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
45 doi:10.1152/physiolgenomics.00068.2005 23:89-102, 2005. First published Jul 26, 2005;Physiol. Genomics
 

Summary:  , adenosine receptors (subtypes A1, A2A, A2B, and A3), to exert a variety of physiological effects (27... tribosylation factor-like 2 (Arl2) 2.2 V00714 Hemoglobin- , adult chain 1 (Hba-a1) 1.9 W13859 RIKEN c... disease 7 (PARK7) 2.0 W35891 Vacuolar protein sorting 4a (yeast) (Vps4a) ...

  

Source: Weng, Zhiping - Center for Advanced Genomic Technology, Boston University

 

Collection: Biotechnology

 
46 Research Article Northern Ring Conformation of Methanocarba-Adenosine
 

Summary:  2340 3 µM MRS 2312 3 µM ATP 3 µM 0.5 nA -1.2 -0.8 -0.4 0.0 -1.2 -0.8 -0.4 0.0 response(nA) DRG M R... . ,-meATP 3 µM MRS 2312 3 µM MRS 2340 3 µM 0.25 nA 1 s -40 -30 -20 -10 0 currentdensity... ** ** 0.5 nA 1 s B C D ATP 3 µM MRS 2312 3 µM MRS 2340 3 µM Fig. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  2A1 AR 2 AR 2 AR 2 AR90° TM4 ICL2 ECL2 TM1 TM6 TM1 H8 TM5 TM6 ECL2 Extracellular surface Out In 90... .50 P5.50 Rhodopsin Adenosine A2A 1 AR2 AR R3.50 E6.30 E/D3.49 Y5.58 a b 2 AR-T4L 2 AR-Fab W6.48 11-cis... -adrenergic receptor.Structure16, 897­905 (2008). 24. Warne, T.etal.Structure of ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
48 Biochem. J. (2006) 396, 193200 (Printed in Great Britain) doi:10.1042/BJ20051772 193 Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via
 

Summary:  adenosine A1 receptors preferentially activated PI3K (phospho- inositide 3-kinase) and ILK (integrin... somatostatin sstr3 receptors, Gi2-coupled - opioid receptors, and Gi3-coupled adenosine A1 receptors cause... and adenosine A1 receptors in smooth-muscle cells are ...

  

Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University

 

Collection: Biology and Medicine

 
49 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  neuromodulator that binds to at least four known G-protein- coupled receptors in the brain (A1, A2A, A2B, and A3... mock pcDNA3.1 (Invitrogen), human A1, or human A2A receptor cDNAs (Missouri S&T cDNA Resource Center... cells transfected with pcDNA3.1 (mock), human adenosine ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
50 American Society of Mammalogists Population Changes and Social Behavior Following Colonization by the Yellow-Bellied Marmot
 

Summary:  ' 9- oAd * ?^ ^ a y , AA] X X a A *A)1 X 8X0 OA AA 0 000/ A x * X X A^~~~x 411 A ACOA?o AC j A o365 Yf... the populationincreased. Adult males attemptedto obtain exclusive use of the area and directed most of their agonistic... they are monogamous. It follows from the model that as harem size increases, ...

  

Source: Blumstein, Daniel T. - Department of Ecology and Evolutionary Biology, University of California at Los Angeles

 

Collection: Environmental Sciences and Ecology

 
51 FAST KINETIC MODELS FOR SIMULATING AMPA, NMDA,
 

Summary:  D2, adenosinergicA1 and histaminergic are likely to act through the same G

  

Source: Boahen, Kwabena - Department of Bioengineering, Stanford University; Destexhe, Alain - Unité de Neurosciences Intégratives et Computationnelles, CNRS

 

Collection: Biology and Medicine ; Computer Technologies and Information Sciences

 
52 Vol. 267, No. 2 Printed in U.S.A.
 

Summary:  , alone I : i i BW 373 pIus . Nalt. -as I> I a) 1.2 -iI . IU I 0 I .C I U) o.s JC I ca I -6 I I 0.4-I V I... ; Chang et al., 1993). #12;2.0 - 1.6 - 1.2 - 0.8 - 0.4 - a, > a, -a 8 U) C .5. `p 2.0 - E16 -a 1.2- . U 0... for Pharmacology and Experimental Therapeutics A Novel Delta Opiold ...

  

Source: Schoenbaum, Geoffrey - Department of Anatomy and Neurobiology, University of Maryland-Baltimore

 

Collection: Biology and Medicine

 
53 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  Publishers Limited. All rights reserved #12;Rhodopsin Adenosine A2A1 AR 2 AR 2 AR 2 AR90° TM4 ICL2 ECL2 TM1... rights reserved #12;D2.50 P7.50 N7.49 Y7.53 W6.48 P6.50 P5.50 Rhodopsin Adenosine A2A 1 AR2 AR R3.50 E6... the molecular underpinnings of antagonist and inverse-agonist ligand ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
54 DOI: 10.1126/science.1146317 , 815 (2007);318Science
 

Summary:  s 100 pA 400 300 200 100 0 Amplitude(pA) DNQX NBQX 10 100 1000 Amplitude(pA) ­1.0 ­0.5 0.5 ­80 ­40 40 80... Agonists TARP Auxiliary Subunits Switch AMPA Receptor www.sciencemag.org (this information is current... .sciencemag.orgDownloadedfrom #12;TARP Auxiliary Subunits Switch AMPA Receptor Antagonists into Partial ...

  

Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
55 ADAPTIVE LINEARIZATION OF THE MUSCLE PLANT
 

Summary:  zero if C(a) -a C(a) + C({3) -a+1" Equation (5.6) implies C(a) -a C"[,B)-{i. (5.7) Thus error signals... to agonist-antagonist muscle pairs. Thus the com- putational unit within the OIl is a spatial pattern... , those in which the agonist inflow signal is an increasing linear function of the amount of ...

  

Source: Grossberg, Stephen - Department of Cognitive and Neural Systems, Center for Adaptive Systems, Boston University

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
56 The Effect of pH on 2 Adrenoceptor Function EVIDENCE FOR PROTONATION-DEPENDENT ACTIVATION*
 

Summary:  .5 12 4 D130A 1.3 0.1 42 12 1.8 0.8 45.7 4.2 17 4 E268A 1.2 0.3 70 22 1.5 0.5 49.6 4.1 28 2 E122A 1.5 0... activation for the 2 adrenergic receptor ( 2AR). The rate of agonist-induced change in the fluorescence... of NBD-labeled, purified 2AR was ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
57 Editorial Manager(tm) for Nuclear Medicine Communications Manuscript Draft
 

Summary:  laboratory to explore strategies of cardioprotection, we set out to clarify whether or not the adenosine A1... there are still controversies on how adenosine receptors (A1, A2A, A2B, and A3) mediate the cardioprotection... , it is generally accepted that the A1 ...

  

Source: Arizona, University of - Center for Gamma-Ray Imaging

 

Collection: Engineering ; Biology and Medicine

 
58 Copyright C Blackwell Munksgaard 2002 Traffic 2002; 3: 866877
 

Summary:  expressing HA-tagged receptors were treated with agonist (C5a 1mM, 30min) or left untreated. Cells were fixed... ' remained at 4æC. The other plates were placed in prewarmed media for 15min, prior to treatment with C5a (1m... of the agonist ligand elicits both ...

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
59 Stimulating electrode AMPA receptor
 

Summary:  receptor: Agonist = N-methyl-D-Aspartate Agonist = AMPA GluGABA Cl- GABAA Interneuron GABAB GABA A receptor... : Agonist = muscimol Cl- GABAA GAD Recording electrode Recording of membrane potential is shown below, along... GABAB receptor Agonist = baclofen Antagonist = phaclofen Antagonist = ...

  

Source: Hasselmo, Michael - Department of Psychology & Computational Neurophysiology Laboratory, Boston University

 

Collection: Biology and Medicine

 
60 JournalofPhysiologyPhysiologyinPress Acetylcholine (ACh) is the major endogenous ligand for
 

Summary:  Hillequationprovidingasingle estimate for the EC50 and Hill coefficient. I(x) = A/(1 + (EC50/x)h ), (1) where I is the mean... exponentials: FR(t) = A(1 _ exp(_t/t1)) + (1 _ A)(1 _ exp(_t/t2)). (3) FR(t) is the fractional recovery... in the upper trace shows 1 s (all ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
61 A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2
 

Summary:  6.9 1.7a Non-desb Non-desb GluR2o 2.0 0.19a 1.9 0.39a Non-desb Non-desb GluR2o(Y450A) No response... A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2 A MUTAGENIC... of Chemistry, Emory University, Atlanta, Georgia 30322 Binding of an agonist to the 2-amino-3-(3-hydroxy-5

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
62 Z .Molecular Brain Research 57 1998 7385 Research report
 

Summary:  analysis of V agonist-induction of NGFI-A1 mRNA demonstrated that within 5 min of exposure to V1 agonist... , and in situ hybridization for NGFI-A demonstrate that V agonist induced NGFI-A1 expression occurs in cells... of NGFI-A gene expression ...

  

Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California

 

Collection: Biology and Medicine

 
63 NPY signaling through Y1 receptors modulates thalamic oscillations
 

Summary:  ). Effects of the Y1 receptor agonist Leu31Pro34NPY (A1 and A2), the Y2 receptor agonist PYY3­36 (B1 and B2... ) and the Y5 receptor agonist BWX-46 (C1 and C2). A1, B1 and C1: Contour plots representing ratemeter... in oscillation duration were ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
64 Evaluation of the Role of IKACh in Atrial Fibrillation Using a Mouse Knockout Model
 

Summary:  to cholinergic and adenosinergic agonists has been previously demonstrated (20,22,23). It is possible that AF... of the muscarinic receptor agonist carbachol. The electrophysiologic features of KO mice were compared with those... administration of the muscarinic agonist carbachol. METHODS GIRK4 knockout ...

  

Source: Clapham, David E. - Department of Neurobiology, Harvard University

 

Collection: Biology and Medicine

 
65 Partial Agonist Activity of 11-cis-Retinal in Rhodopsin Mutants* (Received for publication, May 29, 1997, and in revised form, July 21, 1997)
 

Summary:  .9 5.8 3.6 1.4 17.3 iA G121A 1.6 0.3 2.3 1.3 0.7 pA G121S 0.9 0.2 5.0 2.6 4.1 pA G121T 0.3 0.1 5.6 1... A G121W 2.3 0.4 30.0 6.2 (6) 27.7 pA E113A/G121L 35.1 8.5 46.5 14.5 11.4 pA F261A 1.0 0.2 1.7 0.1 0... Partial Agonist Activity of 11-cis-Retinal in Rhodopsin Mutants* (Received for ...

  

Source: Smith, Steven O.- Department of Biochemistry and Cell Biology, SUNY at Stony Brook

 

Collection: Biology and Medicine

 
66 The rainbow trout skeletal muscle -adrenergic system: characterization and signaling
 

Summary:  displaced to 60% of total binding, although quantitative differences were noted between Dob (a 1-agonist... ). Selective and nonselective -adrenergic agonists ( -AAs) and antagonists indicated an atypical -AR... .45, respectively). The agonist-induced increase in cAMP produc- tion was ...

  

Source: Moon, Thomas W. - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
67 Acta Theriologica 45 (2): 2Ol-2O9, 2OOO. PI, ISSN OOOL_705I
 

Summary:  , iihakovd and Frynta 1996, Frynta and aihdkov6 1996, Suchomelov6.et a1..1998). Considering male... of'amicable behaviour (on average ca 30"/r,of the total tin.re')and verv low proportion of agonistic... distingrrishccl: (1) agonistic behaviour (sum of agg'ressive,neutral and de{ensive behaviours; note: ...

  

Source: Frynta, Daniel - Department of Zoology, Charles University in Prague

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
68 SOMATOSENSORY SYSTEMS, PAIN NEUROREPORT 0959-4965 & Lippincott Williams & Wilkins Vol 11 No 15 20 October 2000 3349
 

Summary:  presentations of white noise (WN; 72 dB, 30 s) and foot shock (1 mA, 1 s). Each training session began with 8... agonists in some neural circuits related to pain modulation. This study examined whether hypoalgesia... following exposure to a signal for shock is attenuated by infusions of the k agonist U69593 ...

  

Source: Helmstetter, Fred J. - Department of Psychology, University of Wisconsin-Milwaukee

 

Collection: Biology and Medicine

 
69 Contribution of Valine 70 Gating of Neuronal a3 Receptor Subtypes
 

Summary:  (a3b2, 1.2 6 0.05; V70 A, 1.6 6 0.14; V70 S, 1.5 6 0.18; V70 F, 0.92 6 0.1; and V70 Y, 1.4 6 013... ). The same is true for a3b4 receptors sub- types (a3b4, 1.3 6 0.01; V70 A, 1.6 6 0.2; V70 S, 1.4 6 0.18; V70... the values from the full Hill plot (a3b2, 1.3 6 0.08; V70 A, ...

  

Source: Lasalde Dominicc, Jose A. - Department of Biology, Universidad de Puerto Rico - Rio Piedras

 

Collection: Biology and Medicine

 
70 Sensitization by Extracellular Ca2 of Rat P2X5 Receptor and
 

Summary:  .2 ATP S 0.29 0.17 0.7 0.2 0.59 0.23a 1.0 0.2 , -meATP 1.1 0.2 a 1.3 0.6 3.2 0.2a 0.8 0.4 BzATP 1.3 0.9a... ATP 11.8 0.2a 1.4 0.6 8.7 0.2 a 0.6 0.4 ADP 3.6 0.3a 1.3 1.0 Inactive UTP 8.2 0.1 a 1.5 0.7 61.2 0.3a 0... .4 0.4 ITP Inactive Inactive UDP Inactive Inactive Ap2A ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
71 JOURNAL OF EXPERIMENTAL ZOOLOGY 284:729741 (1999) 1999 WILEY-LISS, INC.
 

Summary:  -dependent. Pretreatment with 100 µM hexamethonium had no effect on the subse- quent ACh-induced response (Fig. 9A1, A2... with 100 µM hexamethonium (N = 10) had no effect on peak tension (A1)(F = 1.231; P = 0.320; df = 2, 15... mediating this response by examining the effects of selective cholinergic ...

  

Source: O'Gara, Bruce A. - Department of Biological Sciences, Humboldt State University

 

Collection: Biology and Medicine

 
72 Cys-loop receptors: new twists and turns
 

Summary:  been observed as a result of M2­M3 linker region mutations in glycine receptors [43­45], nicotinic a1... of naturally occurring pathological mutations in the M2­M3 linker region of the glycine receptor a1 subunit [43... ,44] and the nicotinic ACh receptor a1 ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
73 Constitutive Activity of a Chimeric D2/D1 Dopamine Receptor LAURA B. KOZELL and KIM A. NEVE
 

Summary:  ,7]. In particular, the affinity of L268A (1.2 M) for dopamine was similar to the affinity of the wild-type D1... intermediate between those of the parent receptors. D2[1­ 4,7] and D2[1­5,7] mediated dopamine receptor agonist... - hanced basal (unliganded) stimulation of cAMP accumulation, high affinity for ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
74 Critical ReviewsTM in Neurobiology, 16(3)187224 [2004] 0892-0915/04 $20.00 2004 by Begell House, Inc. 187
 

Summary:  590021 8.4­921 0.0421 NR1/NR2A1.8­7.722,23 22­23024,31,34 386­750,200024,34 61824 0.28­4225,26 0... of glutamate receptor ion channels,with an emphasis on the functional and structural aspects of how agonist... receptors in that it requires the binding of both glutamate and the co-agonist glycine to the ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
75 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Predicted structures of agonist and
 

Summary:  , the target is often just one of the four subtypes of human ARs, designated A1, A2A, A2B, and A3. The A2A... receptor activation, while the A1 and A3 adenosine sub- types are linked to Gi proteins inhibiting c... to Gq proteins.2 Thus activation of human adenosine A1 ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
76 Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors
 

Summary:  of the electrophysiological ac- tions of the more selective mGlu receptor agonists are mentioned briefly. This discussion... ), respectively. A brief overview of only the various agonists and antagonists of mGlu receptor subtypes that have... the recent articles by Pin et al. (1999) and Schoepp et al. (1999). The nonselective ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
77 Agonist-activated ion channels *David Colquhoun
 

Summary:  type) a1 subunit (which has 462 amino acids), and lacks the membrane crossing regions, the pore... . & SIVILOTTI, L.G. (2004). The activation mechanism of a1 homo- meric glycine receptors. J. Neurosci., 24, 895... Agonist-activated ion channels *David Colquhoun Department of ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
78 Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action
 

Summary:  et de Formation, Bureau 207, 1033 Avenue des Pins Ouest, Montre´ al, QC, H3A 1A1 Canada 2Universite... Neuron Article Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset... effective only after several weeks of administration. Here, we show that ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
79 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  Main Distribution Agonists Antagonists Transduction Mechanisms P1 (adenosine) A1 Brain, spinal cord... receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... to be involved in ligand recognition (1275). Site-directed mutagenesis of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
80 Mathematical Model of Network Dynamics Governing Mouse SleepWake Behavior
 

Summary:  . Population-dependent parameters (Table A1 in the APPEN- DIX) determine slightly different intrinsic... and their typical values are listed in Tables A1 and A2 of the APPENDIX. Mathematical understanding of state... - transmitter agonists and antagonists (Saper et al. 2005). We classify ...

  

Source: Kopell, Nancy - Center for BioDynamics, Boston University

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
81 J. Physiol. (1979), 293, pp. 247-284 247 With 16 text-figurew
 

Summary:  are illustrated in Fig. 1 (A 1 at - 70 mV and B1 at - 120 mV). It is quite likely that some desensitization... is more or less linear in Fig. 1 (A 1-B3) but if Al c 0 (N A3 251 #12;D. COLQUHOUN, F. DREYER AND R. E... can be seen on 10- 21 PS 178,179.-120 mV 0~~~~~ i , , CCh (60pM) + TC(3PM) _ ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
82 New and Notable From Shut to Open: What Can
 

Summary:  . Sivilotti. 2004. Single-channel behavior of heteromeric a1b glycine receptors: an attempt to detect... to expand Bernard Katz's mechanism by asking how it is that the binding of an agonist causes the channel... of agonist and for gating of the channel (or, in pharmacological terms, the separate estimation ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
83 4-Methylhomoibotenic Acid Activates a Novel Metabotropic Glutamate Receptor Coupled to Phosphoinositide Hydrolysis1
 

Summary:  injected with mGluR1 RNA was 15.2 nA 11.9 (n 8) and 9.3 nA 1.9 (n 4) respectively, compared to a mean... . Neurosci. Methods 59: 105­110, 1995. SCHOEPP, D. D., JOHNSON, B. G. AND MONN, J. A.: (1S,3R)-1... mGluR1a, BrHI is a weak partial agonist whereas MHI has no ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
84 Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models
 

Summary:  compounds Adenosinergic system Caffeine 100 mg/L immersed for 15 min Novel tank (wild type) Longer latency... (2011) 1421­1431 #12;prototypical opioid receptor agonist, whereas its competitive antag- onist naloxone... receptor inverse agonist FG-7142 on zebrafish (Table 1), this indicates that inhibition of the GABA

  

Source: Kalueff, Allan V. - Department of Pharmacology, Tulane University

 

Collection: Biology and Medicine

 
85 ACCELERATED COMMUNICATION Aspartate Aminotransferase Generates Proagonists of the Aryl
 

Summary:  from the agonist(s) derived from I3P alone. I3P Derivatives Bind the Active Site of CYP1A1. We... P derivatives Fig. 4. I3P spontaneously forms agonists of AHR that bind CYP1A1. A, 101L cells were... 450 monooxygenases 1A1 ...

  

Source: Bradfield, Christopher A. - McArdle Laboratory for Cancer , University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
86 Novel 5-HT7 receptor inverse agonists. Synthesis and Molecular Modeling Chapter 7 7 Novel 5-HT7 receptor inverse agonists. Synthesis and
 

Summary:  Novel 5-HT7 receptor inverse agonists. Synthesis and Molecular Modeling Chapter 7 149 7 Novel 5-HT7... receptor inverse agonists. Synthesis and Molecular Modeling of Arylpiperazine- and 1... or inverse agonists16,20,22,23,25,27,28,32,34-36,39,51,54,62,64,71 . In the process of characterization

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
87 Arterioscler Thromb Vasc Biol . Author manuscript Fibrates, glitazones, and peroxisome proliferator-activated receptors
 

Summary:  of the transporters scavenger receptor-BI and ATP-binding cassette transporter A-1 in macrophages. Thus... of their agonists to the subsequent discovery of these receptors and their mechanisms of action, to finally evoke... effects ; Peroxisome Proliferator-Activated Receptors ; agonists ; history ; ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
88 Adenosine Released by Astrocytes Contributes to Hypoxia-Induced Modulation of Synaptic Transmission
 

Summary:  of excitatory synaptic transmission me- diated by activation of presynaptic A1 adenosine receptors. The glia... -specific metabolic inhibitor fluorocitrate (FC) was as effective as the A1 adenosine receptor antagonist CPT... the excitatory synaptic transmission through the release of adenosine, which acting ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
89 J. Physiol. (1985), 369, pp. 501-557 501 With 1 plate and 18 text-figures
 

Summary:  V) was 1/a = 1-4 ms (about one-third ofthe burst length), so the conformational equilibrium constant was f8... that correspond to the dashed line in Fig. 2 being Tf = 56-4 #s (af = 72-5 %) and Tr = 239 ms (a1 = 27... component was 339 ms (29-6 %). !, !~rl Ifs, IIA i; I'O,.o .0 'A ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
90 The quantitative analysis of drugreceptor interactions
 

Summary:  be written simply in the form: pA Z cA 1 CcA CcB ; where cA is the normalised concentration of A, c... description that can describe quantitat- ively the actions of agonists on G-protein-coupled receptors... , although progress has been greater with agonist-activated ion channels, which are much simpler. ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
91 An Intersubunit Hydrogen Bond in the Nicotinic Acetylcholine Receptor that Contributes to Channel Gating
 

Summary:  182A 1.2 ± 0.08 S191SahE176AE182A 32 ± 1.7 0.27 ± 0.06 E176QE182Q 2.0 ± 0.10 S191SahE176QE182Q 51 ± 2... in loop C makes a hydrogen bond to an anionic side chain of the complementary subunit upon agonist binding... aspartate D174/D180--which had originally been identified as a key binding residue for cationic ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
92 Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety
 

Summary:  Interval EC50 Hill Coefficient M ATP 0.60 0.47­0.77 0.8 0.1 Ap5A 1.50 1.15­1.95 1.1 0.1 Ap5G 2.26 1... hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol 119:835­844. Valera S, Hussy N, Evans RJ, Adami... did not show significant activity. For the rP2X1 receptor, ApnAs and ApnGs were partial ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
93 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  agonists all stimulated membrane capacitance after being administrated serosally, only the A1 agonist... of the following adenosine receptor- selective agonists to induce changes in membrane capacitance: the A1-selective... ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
94 Functional Contribution of a3L80 Neuronal Nicotinic a3 Receptor
 

Summary:  of four different polypeptide subunits (a1, b1, g or e, and d) with subunit stoichiometry of 2a:1b:1g or e... Enhancement (RISE) Program (NIH grant-1-R25-GM61151-01A1). D.C. was sponsored by the Graduate Assistance... in losses in agonist (ACh, ...

  

Source: Lasalde Dominicc, Jose A. - Department of Biology, Universidad de Puerto Rico - Rio Piedras

 

Collection: Biology and Medicine

 
95 J Physiol 587.21 (2009) pp 50455072 5045 Agonist and blocking actions of choline
 

Summary:  J Physiol 587.21 (2009) pp 5045­5072 5045 Agonist and blocking actions of choline... , Gower St, London, UK Choline has been used widely as an agonist for the investigation of gain... -of-function mutants of the nicotinic acetylcholine receptor. It is useful because it behaves like a partial agonist

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
96 JournalofPhysiology It has long been known that tetraethylammonium (TEA),
 

Summary:  blocked. The inverse of the mean duration of such a burst is (1/t) = a(1 _ fraction of time blocked) ~a... is that a channel blocked by TEA can still close. In this case, z = a(1 _ fraction of time blocked) + f... state did not affect the association of ACh to the agonist recognition ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
97 History of Discovery : Fibrates, Glitazones and Peroxisome Proliferator-Activated Receptors
 

Summary:  -00475566,version1-22Apr2010 #12;6 scavenger receptor-BI and ATP-binding cassette transporter A-1... the clinical development of their agonists to the subsequent discovery of these receptors and their mechanisms... activating PPAR/ that are approved for clinical treatment, new synthetic PPAR/ agonists are in ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
98 Neuropharmacology 39 (2000) 364371 www.elsevier.com/locate/neuropharm
 

Summary:  . Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes... of the inhibitory agonist. This phenomenon has been referred to as adenylyl cyclase superactivation and is believed... of the inhibitory agonist (Sharma et al. 1975, 1977; Hamprecht, 1977; ...

  

Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
99 Virodhamine and CP 55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells
 

Summary:  antagonists SR141716A (1 µM) and SR144528 (1 µM) on basal and forskolin (0.1 µM) induced cAMP accumulation... M), but remained largely unaffected by the CB1R antagonist SR141716A (1 µM) (Figures 3a and 3b, Table 1). Both... cAMP accumulation. (a) Virodhamine-induced inhibition in the presence of ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
100 ABBREVIATIONS: NMDA, N-methyl-D-aspartate; AMPA, ct-amino-3-hydroxy-4-methylisoxazolepropionic acid; DDB, 2,5-dihydro-2,5-dioxo-1H-ben-zazepine; DDHB, 2,5-dihydro-2,5-dioxo-3-hydroxy-1H-benzazepine; 4-Br-DDHB, 7-Me-DDHB, and 8-Me-DDHB, 4-bromo, 7-methyl,
 

Summary:  ) (1 3 applications in four cells) or in the presence of 8 8-Me-DDHB (A) (1 3 applications in five... 63 150 pA 1 5 sec B Glutamate (pM) + 50 pM 8-Me-DDHB 4 16 63 250 10_6 i#{252}- i- IG)utamatel, (M... = 770 pM io -5 -10 C.) LU i06 100 pA 20 sec KB= 470 pM 300 pA 1 5 ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine


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