Summary:  viability by a Trypan blue exclusion assay. We found that 500nM of 17-AAG and 17-DMAG induced an increase... control) or 50nM of the GA-derived Hsp90 inhibitors, 17-AAG and 17-DMAG, that are currently in clinical... -based cell proliferation assay (Fig. 7A). We also determined the IC50 of ...

Source: Damania, Blossom - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

Collection: Biology and Medicine

Summary:  that is induced by 17AAG, coupled to the impaired clearance of proteins by the ubiquitin­pro- teasome pathway128... 17AAG, which is the first in its class. · Work is ongoing to identify and develop new HSP90... , 17AAG, radicicol phosphate of ...

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

Collection: Biology and Medicine

Summary:  -EGFR. Consistent with this prediction, after treatment with 17-AAG, a specific HSP90 inhibitor (Chiosis et al... supporting a stabilizing role toward mutant receptors. Concomitantly, 17-AAG reduced tyrosine phosphorylation... that the dimeric form might be more sensitive to ...

Source: Maoz, Shahar - Department of Computer Science and Applied Mathematics, Weizmann Institute of Science

Collection: Computer Technologies and Information Sciences

Summary:  -dependent, and inhibitors that bind at the ATP active site, for example, geldanamycin (GA) and its derivative 17-AAG, have... already shown promise as anticancer agents (7, 8). 17-AAG has anti- *Corresponding author, lynne... . Encouraging results have been obtained by inhibiting Hsp90 with ...

Source: Mochrie, Simon - Department of Applied Physics, Yale University; Regan, Lynne - Department of Molecular Biophysics and Biochemistry, Yale University

Collection: Biology and Medicine ; Biotechnology ; Materials Science ; Physics

Summary:  include herbimycin A (Hegde et al., 1995), radicicol, geldanamycin, and 17-AAG sistant tumor cell lines... (Table 1). Geldanamycin or 17-AAG re- sulted in a 10-fold, or greater, increase in ONYX-015 replication... - cells, and bronchial epithelial cells (Figure 7C and Table S2). Treatment with ...

Source: Sejnowski, Terrence J. - Computational Neurobiology Lab, Salk Institute for Biological Studies

Collection: Biology and Medicine

Summary:  induced by the Hsp90 inhibitor 17-AAG (Fig. 1A). We chose to compare the levels of endogenous kinases... denoted G778D) stabilized the receptor toward 17-AAG-induced ubiquitylation/degradation and enhanced... of endogenous DAPK was induced following inhibition of ...

Source: Kimchi, Adi - Department of Molecular Genetics, Weizmann Institute of Science

Collection: Biology and Medicine

Summary:  ; MG132, carbobenzoxy-L- leucyl-L-leucyl-leucinal; 17-AAG, 17-N-allylamino-17-demethoxygeldanamycin... 90 inhibitors: Radicicol 1­10 M 40, 43 Geldanamycin 0.1­1 M 39, 40, 42, 43 17-AAG 0.1­1 M 40... as cancer therapies (37). 17-AAG, a related analogue of ...

Source: Morimoto, Richard - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

Collection: Biology and Medicine

Summary:  -489 PHASE DIAGRAM FOR CELL CYTOPLASM FROM THE CALF LENS John I. Clark and George B. Benedek Center... for cytoplasmic homogenate isolated from the cells of calf lenses. In the intact iens, this material is associated... ,000 and 55,000 daltons. Scanning electron microscopy shows that the phase separation in the cytoplasmic

Source: Washington at Seattle, University of - Structural Informatics Group (SIG)

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

Summary:  mesophyll or root cells, induce cytoplasmic motion that is an important component of the physiological... :1666­1672 Hayashi T, Takagi S (2003) Ca2+ -dependent cessation of cytoplasmic streaming induced by hypertonic... NEW IDEAS IN CELL BIOLOGY Cytoplasmic streaming enables the ...

Source: Goldstein, Raymond E. - Department of Applied Mathematics and Theoretical Physics, University of Cambridge

Collection: Physics

Summary:  Mechanism of genotoxicity induced by targeted cytoplasmic irradiation M Hong1,2 , A Xu1,3 , H Zhou1... ­hamster hybrid (AL) cells. RESULTS: Targeted cytoplasmic irradiation induces oxidative DNA damages and reactive... involving reactive oxygen/nitrogen species and COX-2 in the ...

Source: Nevis Laboratories, Radiological Research Accelerator Facility

Collection: Fission and Nuclear Technologies ; Biology and Medicine

Summary:  ; the solely cytoplasmic irradiation induced vacuolar degeneration developing gradually and lethally... ), though the mechanisms are largely unknown. However, since the effects induced by cytoplasmic irradiation... that nuclear irradiation induced 3-4-fold more mutants than ...

Source: Nevis Laboratories, Radiological Research Accelerator Facility

Collection: Fission and Nuclear Technologies ; Biology and Medicine

Summary:  ;14 17-AAG: 17-Allylamino-17- demethoxygeldanamycine 17-DMAG: 17-Dimethylamino-ethylamino- 17... précédemment montré que c-IAP1 migre du noyau vers le cytoplasme au cours de la différenciation cellulaire... ensemble du noyau vers le cytoplasme au cours de la différenciation cellulaire. L'inhibition de ...

Source: Ecole Polytechnique, Centre de mathématiques

Collection: Mathematics

Summary:  Signals Causing an ____________________ Calcium Ions Cytoplasmic Calcium Levels... in Extracellular Fluid, the ER or Plant Vacuoles are ______________ Abnormally High Cytoplasmic Calcium Levels... ________________________ Channels This Allows into the Cytoplasm, Calcium from the Extracellular Fluid, Triggering

Source: Cutler, Chris - Department of Biology, Georgia Southern University

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  Life at High Péclet Numbers R E Goldstein DAMTP #12;III Microfluidics of Cytoplasmic Streaming... Flow pattern #12;Cytoplasmic Streaming (Cyclosis) Algae: Chara, Nitella, Acetabularia, ... Plants... of cellular sap (cytoplasm) · Organelles coated with myosin are transported along actin filaments · Steady

Source: Goldstein, Raymond E. - Department of Applied Mathematics and Theoretical Physics, University of Cambridge

Collection: Physics

Summary:  and Induces Cytoplasmic Vacuoliza- tion (A) MTT assays of A875 cells treated with DMSO, 20 mM PES, or 50 m... - geldanamycin (17-AAG) (Figure 6J and data not shown), sug- gesting that the actions of PES are distinct from... with a concomitant reduction of LC3-II levels (Figure 6K), and retarded the appearance ...

Source: Hardy, Christopher R. - Biology Department, Millersville University

Collection: Environmental Sciences and Ecology

Summary:  , Base1 Cytoplasmic incompatibilities in the mosquito C&x pipiens: How to explain a cytotype polymorphism... -34033 Montpellier Cedex, France Key words: Cytoplasmic incompatibility; nuclear-cytoplasmic inheritance... ; Culex pipiens; stable polymorphism; sterility. Abstract Although cytoplasmic ...

Source: Blatrix, Rumsais - Centre d’Ecologie Fonctionnelle et Evolutive; Lebreton, Jean-Dominique - Centre d’Ecologie Fonctionnelle et Evolutive

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  A model of cytoplasmically driven microtubule- based motion in the single-celled Caenorhabditis... of cytoplasmically driven microtubule-based pronuclear motion in the single-celled Caenorhabditis elegans em- bryo... . These MTs encounter motor proteins, distributed throughout the cytoplasm, that attach and exert a pulling

Source: Shelley, Michael - Department of Mathematics, Courant Institute of Mathematical Sciences, New York University

Collection: Mathematics

Summary:  of Cytoplasmic Irradiation. Cytoplasmic irradiation induces minimal toxicity in AL cells, as shown in Fig. 2... . 4, lower right). The difference in mutant spectra induced by nuclear versus cytoplasmic irradiation... traversals through the cytoplasm. ...

Source: Nevis Laboratories, Radiological Research Accelerator Facility

Collection: Fission and Nuclear Technologies ; Biology and Medicine

Summary:  ARTICLE Wolbachia-Induced Cytoplasmic Incompatibility in Single- and Superinfected Aedes albopictus... virulence. Both single- and superinfections induced high levels of cytoplasmic incompatibility throughout... that induce cytoplasmic incompatibility in mosquitoes ...

Source: Dobson, Stephen L. - Department of Entomology, University of Kentucky

Collection: Environmental Sciences and Ecology ; Biotechnology

Summary:  to that induced by live A496 bacteria. These results showed clearly that the cytoplasmic extract of the strain A... of Pathogenic Vibrio Cytoplasmic Extract Christophe Lambert,* Jean-Louis Nicolas,* and Valérie Bultel... this same CL biotest, V. pectenicida and S322 cytoplasmic extracts were shown to ...

Source: Ecole Polytechnique, Centre de mathématiques

Collection: Mathematics

Summary:  C H A P T E R T W E L V E Determining In Vivo Activity of the Yeast Cytoplasmic Exosome Daneen... Degraded and/or Processed by the Exosome? 229 2.1. Core exosome mutants 229 2.2. Mutants in cytoplasmic... exosome cofactors 231 2.3. Nuclear exosome cofactors mutants 231 3. Is the Cytoplasmic Exosome Active

Source: van Hoof, Ambro - Department of Microbiology and Molecular Genetics, University of Texas Health Science Center Houston

Collection: Biology and Medicine

Summary:  at metaphase induced a cytoplasmic and nuclear interphase arrest in the next cycle (Fig. 1 C, left). Exogenous... injected embryos, 32-M CycB dilution induced cytoplasmic and nuclear CDK1 activation at a similar rate... not induce premature NEB (Fig. 2 D). This uncoupling be- tween the ...

Source: Sullivan, William T. - Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz

Collection: Biology and Medicine

Summary:  organisms like yeast, Dictyostelium, and Drosophila. We are using nurse cell cytoplasm transport during... cytoplasm is transported rapidly into the oocyte by a process involving two actin filament networks... . The subcortical actin network supports myosin-based nurse cell contraction that pushes nurse cell cytoplasm

Source: Cooley, Lynn - Department of Genetics, Yale University

Collection: Biology and Medicine

Summary:  Minireview mRNA Binding Proteins hnRNPs Regulate Cytoplasmic mRNA Localization Localization of RNAs... into the myelin-Houston, Texas 77030 forming processes of these cells. This cytoplasmic local- ization was later... of directing the generation cytoplasm, this suggested the possibility that A2 playsof a protein

Source: Wilkinson, Miles F. - Department of Reproductive Medicine, University of California at San Diego

Collection: Biology and Medicine

Summary:  79 CHAPTER 7 FUNCTIONS OF THE CYTOPLASMIC EXOSOME Daneen Schaeffer, Amanda Clark, A. Alejandra... the cytoplasm and nucleus of eukaryotic cells. The cytoplasmic exosome has been extensively characterized... that most functional aspects are conserved. These studies have implicated the cytoplasmic ...

Source: van Hoof, Ambro - Department of Microbiology and Molecular Genetics, University of Texas Health Science Center Houston

Collection: Biology and Medicine

Summary:  Review Genetic Analysis of the Cytoplasmic Dynein Subunit Families K. Kevin Pfister*, Paresh R... of this diverse group of proteins, highlighting the existence of two cytoplasmic dynein complexes with distinct... -directed molecular motors that can be divided, based on function, into two classes: axonemal and cytoplasmic dyneins

Source: Cotton, James - School of Biological and Chemical Sciences, Queen Mary, University of London

Collection: Environmental Sciences and Ecology ; Biology and Medicine

Summary:  to direct cytoplasmic accumulation when fused to a het- erologous protein. Mutations in conserved NES... to repres- sion of its own expression (4). A region of the dPER protein termed the cytoplasmic localization... )) maintains monomeric dPER in the cytoplasm, where it is phosphorylated and degraded. When the Drosophila

Source: Ullman, Katie - Huntsman Cancer Institute, University of Utah

Collection: Biology and Medicine

Summary:  ). In the absence of active signaling, NF- B is typically found in the cytoplasm in a 2:1 complex with its binding... , ubiquitination and proteosome- mediated degradation of I- B frees NF- B from cytoplasmic anchoring, allowing... , syncytial blastoderm nuclei undergo four complete mitotic divisions within a shared cytoplasm ...

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

Collection: Biology and Medicine

Summary:  and the cytoplasm Miles F. Wilkinson1 * and Ann-Bin Shyu2 Summary The multistep pathway of eukaryotic gene... expression involves a series of highly regulated events in the nucleus and cytoplasm. In the nucleus, genes... RNAs are then transported to the cytoplasm, where they are translated into protein and degraded at a rate ...

Source: Wilkinson, Miles F. - Department of Reproductive Medicine, University of California at San Diego

Collection: Biology and Medicine

Summary:  of the bHLHZip family of transcriptional regulators, MondoA and Mlx have the unique property of cytoplasmic... that for both MondoA and Mlx, this C-terminal domain has cytoplasmic localization activity that is required... by the protein monomers to accumulate in the cytoplasm. This C-terminal domain is also a novel dimerization

Source: Ayer, Don - Huntsman Cancer Institute, University of Utah

Collection: Biology and Medicine

Summary:  of hA3G with CRS activity could be positively identified by their ability to induce cytoplasmic... . HIV-1 Vif interacts with hA3G in the cytoplasm to induce its ubiquitination and degradation (53... 1 Nuclear Exclusion of the HIV-1 Host Defense Factor APOBEC3G Requires a Novel Cytoplasmic

Source: Wedekind, Joseph E. - Department of Biochemistry and Biophysics, University of Rochester

Collection: Biology and Medicine

Summary:  - sion coefficients (ADCs) from the cytoplasm (with relative frac- tion) were 0.48 0.14 10­3 mm2 s­1 (61... %) for the slow (N 5). The slow component in the nucleus may be explained by cytoplasmic volume averaging... . These data demonstrate that water diffusion in the cytoplasm of isolated single Aplysia neu- rons supports

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

Collection: Biology and Medicine

Summary:  the elasticity of the cytoplasm of HUVECs in a matrix. This VEGF-induced softening response of the cytoplasm... ) describes the local deformation of the cytoplasm induced by the fluctuating forces acting on the surface... describes the local deformation of the ...

Source: Sniadecki, Nathan J. - Department of Mechanical Engineering, University of Washington at Seattle

Collection: Biology and Medicine ; Engineering

Summary:  1 Cytoplasmic CstF-77 protein belongs to a Masking Complex with CPEB in Xenopus Oocytes Christel... , CNRS, 1919 route de Mende, 34293 Montpellier cedex 05, France Running title: Cytoplasmic CstF-77... .mandart@crbm.cnrs.fr Regulated mRNA translation is a hallmark of oocytes and early embryos, of which cytoplasmic polyadenylation

Source: Ecole Polytechnique, Centre de mathématiques

Collection: Mathematics

Summary:  Cytoplasmic-to-nuclear volume ratio affects AP-1 complex formation as an indicator of cell cycle... Posas Abstract Cytoplasmic volume undergoes a series of changes during mitosis in eukaryotes; in turn... , signaling events such as os- motic stress can regulate the cytoplasmic volume in cells. In some organisms

Source: Kurnaz, Levent - Department of Physics, Bogaziçi University

Collection: Materials Science ; Physics

Summary:  Cytoplasmic regulation of the accumulation of nuclear-encoded proteins in the mitochondrial... )- and Texas (T)-cytoplasm maize (Zea mays L.) were puri®ed from unpolli- nated ears via Percoll centrifugation... the mitochondrial proteomes of NA- or T-cytoplasm maize plants that had essentially identical nuclear genomes

Source: Schnable, Patrick S. - Center for Plant Genomics & Department of Genetics, Development and Cell Biology, Iowa State University

Collection: Biology and Medicine ; Biotechnology

Summary:  in which SpoIVFB-GFP localizes to all membranes but is selectively eliminated from the cytoplasmic membrane... IVFB-GFP achieves proper localization by insertion into the cytoplasmic membrane followed by diffusion to... membranes within the mother cell: the cytoplasmic membrane, which delimits the periphery of the cell

Source: Rudner, David - Department of Microbiology and Molecular Genetics, Harvard University

Collection: Biology and Medicine

Summary:  with minimal activity on their own, the Hsp90 inhibitors 17-(allylamino)-17-demethoxygeldanamycin (17-AAG... That Are Well Tolerated in Humans, 17-AAG and 17-DMAG, Have Synergistic Antifungal Activity with FL Against C... development as anticancer agents, 17-AAG and ...

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

Collection: Biology and Medicine

Summary:  . The cytoplasmic tail of R1 induces cellular phosphorylation. Calcium mobilization and NFAT activation... are indicators of lymphocyte activation. The ability of the cytoplasmic tail of R1 to induce calcium mobilization... protein (Fig. 5A). We next tested the abilities of the different R1 ...

Source: Damania, Blossom - Department of Microbiology and Immunology, University of North Carolina at Chapel Hill

Collection: Biology and Medicine

Summary:  embryos, cytoplasmic reorganization prior to the first cleavage generates visibly distinct domains of yolk... -deficient cytoplasm, called telopZo.sm.During an ensuing series of stereotyped and unequal cell divisions, teloplasm... stratifies the cytoplasm of each cell, generating a layer of clear cytoplasm in ...

Source: Weisblat, David A. - Department of Molecular and Cell Biology, University of California at Berkeley

Collection: Biology and Medicine

Summary:  be regulated? · Ligand-induced allostery · GTP hydrolysis induced allostery · Phosphoylation induced allostery... ((,'-(J#( #12;Phosphorylation-induced allostery is most common form of eukaryotic protein regulation... shape by inducing attraction or repulsion within protein! ...

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

Collection: Biology and Medicine

Summary:  induces neurodegeneration. Cytoplasmic TDP-43 predicts neuronal death Next, we used automated fluorescence... induces the mislocalization of TDP43-EGFP from the nucleus to the cytoplasm in transfected neurons... mutation induces toxicity through cytoplasmic mis- ...

Source: Wu, Jane Y. - Center for Genetic Medicine & Department of Neurology, Northwestern University

Collection: Biology and Medicine

Summary:  . They distort their hosts' reproduction, inducing parthenogenesis, feminization and cyto- plasmic... related. Cytoplasmic incompatibility causes embryonic mortality in crosses between infected male hosts... correspondence 852 NATURE | VOL 391 | 26 FEBRUARY 1998 tions without the action of cytoplasmic incompatibility

Source: Dobson, Stephen L. - Department of Entomology, University of Kentucky

Collection: Environmental Sciences and Ecology ; Biotechnology

Summary:  MEETING ABSTRACT Open Access Predominant role of Tax sumoylation in Tax-induced NF-kB activation... of the NF-kB pathway, a property that is required for HTLV-1-induced T cell immortalization. Tax activates... the NF-kB pathway by acting both at cytoplasmic and nuclear levels. In the cytoplasm, Tax binds

Source: Ecole Polytechnique, Centre de mathématiques

Collection: Mathematics

Summary:  Vasopressin-Induced Cytoplasmic and Nuclear Calcium Signaling in Embryonic Cortical Astrocytes... ). Surprisingly, we discovered that V1 agonist-induced Ca2 led to a rise in both cytoplasmic ([Ca2 ]c) and nuclear... , 2003 · 23(10):4228­4239 #12;cated that V1 agonist induced an initial ...

Source: Brinton, Roberta Diaz - Laboratory for Neuroscience Research & School of Pharmacy, University of Southern California

Collection: Biology and Medicine

Summary:  Cytoplasmic Domain (3) Depending on the Type of Receptor Activation can Transmit a Signal to an (Effector... ___________________ Amino Acids but Some Types Phosphorylate _____________ Some __________________ are Cytoplasmic Proteins... :- ___________________________________________________) these Induce Sleep, Regulate Pain, ...

Source: Cutler, Chris - Department of Biology, Georgia Southern University

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  calcium concentrations also induce an opacification in len~ cytoplasmic extracts, even when those... induced by the addition of calcium is found to he much larger than the scattering by normal lens cytoplasm... is unaffected and that the perturbations induced by calcium only bear on a ...

Source: Washington at Seattle, University of - Structural Informatics Group (SIG)

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

Summary:  , but distinct differences between the cytoplasmic tails, which are presumed to provide the linkage... : selective cell sorting, and the mechanical cytoplasmic response including the interaction with the force... cadherins into mes- enchymal cells induces an apparent epithelialization and selective sorting of the cells

Source: Geiger, Benjamin - Department of Molecular Cell Biology, Weizmann Institute of Science

Collection: Biology and Medicine

Summary:  the ratio of induced strains measured in regions of the cytoplasm and nucleus when placed at the same... induced by Noc resulted in both increased lateral contraction of the cytoplasm (i.e, in- creased Poisson... surface receptors can immediately change the organization of molec- ular assemblies in the ...

Source: Ingber, Donald E. - Vascular Biology Program, Harvard University; Sniadecki, Nathan J. - Department of Mechanical Engineering, University of Washington at Seattle

Collection: Biology and Medicine ; Engineering

Summary:  OF NUCLEAR AND CYTOPLASMIC GENES JOHANNEs A. J. BREEUWERI,2 AND JOHN H. WERRENI 'Department of Biology... of the two species, and between cytoplasmically inherited factors (cytoplasmic genes) of giraulti and nuclear... genes of vitripennis. Interactions between nuclear genes and cytoplasmic genes are ...

Source: Werren, John H. - Department of Biology, University of Rochester

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  inducing genes i. Rf1 in maize with T-cytoplasm ii. Restoration of Brassica napus pol and nap sterile... for crop breeding, fst does not. c. Arises spontaneously via mutations in nuclear and/or cytoplasmic genes... ) b. Genotypic (fig 1.1) i. Genic male sterility: Mendelian inheritance due to nuclear not ...

Source: Bhattacharyya, Madan Kumar - Department of Agronomy, Iowa State University

Collection: Biology and Medicine

Summary:  parasites and conspecific competitors. I also discuss the antagonistic interaction between cytoplasmic... and nuclear genes in cytoplasmic male sterility. Data from these studies suggest that spatial variation... system is cytoplasmic male sterility in hermaphroditic plants. I will describe the details of this system

Source: Frank, Steven A. - Department of Ecology and Evolutionary Biology, School of Biological Sciences, University of California, Irvine

Collection: Environmental Sciences and Ecology ; Biology and Medicine

Summary:  The a Subunit Cytoplasmic Domain Regulates the Assembly and Adhesiveness of lntegrin Lymphocyte... , how cytoplasmic signals result in conformational changes and ligand binding in the extracellular do... distribution (21). Bind- ing of Mn2+ or Mg2+ has been documented to directly induce an active conformation

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

Collection: Biology and Medicine

Summary:  of the first- generation HSP90 inhibitor tanespimycin (17-AAG) to trastu- zumab therapy has demonstrated... of trastuzumab and tanespimycin (17-AAG, KOS- 953) is safe and active in trastuzumab-refractory HER-2... . (2011) HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin ...

Source: Lindquist, Susan - Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology (MIT)

Collection: Biology and Medicine

Summary:  in the cytoplasm, does not bind to importins, which are exported from the nucleus in association with Ran... the geographical subdivision of nucleus and cytoplasm. Current models for mitotic-spindle assembly postulate... findings on cytoplasmic roles for Ran and on new mechanisms for Ran regulation in ...

Source: Fainzilber, Michael - Department of Biological Chemistry, Weizmann Institute of Science

Collection: Biology and Medicine

Summary:  Commentary CommentaryCommentary Adaptive nature of crop cytoplasm Concerns persist over the escape of transgenes from... (Fig. 1) and the apparent positive effect of the crop cytoplasm on fitness of wild plants in riverside... with Allainguillaume et al. (2009a), they found that F1 hybrids (with crop cytoplasm) that emerge and ...

Source: 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

Summary:  that the local association of talin with these sites is induced by the cytoplasmic tail of 1 integrin recep- tor... with a chimeric cDNA encoding the cytoplasmic and transmembrane domains of 1 integrin and the extra- cellular... - tion is directed by its 1 integrin segment, presumably via interactions of the ...

Source: Geiger, Benjamin - Department of Molecular Cell Biology, Weizmann Institute of Science

Collection: Biology and Medicine

Summary:  binding induces receptor dimerization and leads to trans- phosphorylation of tyrosines in the cytoplasmic... .shilo@weizmann.ac.il DOI 10.1016/j.cell.2010.09.042 The receptor tyrosine kinase ErbB is activated by ligand-induced... dimerization, leading to trans- phosphorylation of the cytoplasmic kinase ...

Source: Shilo, Benny - Department of Molecular Genetics, Weizmann Institute of Science

Collection: Biology and Medicine

Summary:  , chromosomes, and cytoskeleton during mitosis. The mitotic cell must divide its nucleus and cytoplasm. Nu... maturation, chro- mosome alignment, and segregation (1). Cytoplasmic division is less precise. It relies... , and membrane-bounded organelles (2). How nuclear and cytoplasmic division is coordinated is not known. Many

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

Collection: Biology and Medicine

Summary:  -isotropic voxels, and imaging noise. Intra-nuclear and cytoplasmic FISH signals are associated spatially... within 2 min after neuronal activity. Subse- quently the Arc RNA translocates to the cytoplasm where... behavioral ex- periences. A variation of Arc catFISH utilizes another IEG, Homer 1a instead of cytoplasmic

Source: Lin, Gang - Department of Electrical, Computer and Systems Engineering, Rensselaer Polytechnic Institute

Collection: Computer Technologies and Information Sciences

Summary:  of Wolbachia-induced cytoplasmic incompatibility on host population size in natural and manipulated systems... by individual survivorship in the #12;Wolbachia-induced cytoplasmic incompatibility S. L. Dobson and others 439... uninfected daughters produced by both #12;440 S. L. Dobson and others ...

Source: Halligan, Daniel - Institute of Evolutionary Biology, University of Edinburgh; Jiggins, Francis - Department of Genetics, University of Cambridge

Collection: Environmental Sciences and Ecology

Summary:  of Wolbachia-induced cytoplasmic incompatibility on host population size in natural and manipulated systems... survivorship in the #12;Wolbachia-induced cytoplasmic incompatibility S. L. Dobson and others 439 Table 1... recovers. Nmin is dependent upon #12;Wolbachia-induced ...

Source: Dobson, Stephen L. - Department of Entomology, University of Kentucky; Fox, Charles W. - Department of Entomology, University of Kentucky

Collection: Biotechnology ; Environmental Sciences and Ecology

Summary:  an abundance of non- neutral cytoplasmic genetic variation within species, which suggests that we should... no longer consider the cytoplasm an idle intermediary of evolutionary change. Nonneutrality of cytoplasmic... that the fate of any given cytoplasmic genetic mutation is directly tied to its performance ...

Source: Arnqvist, Göran - Department of Animal Ecology, Uppsala Universitet; Dowling, Damian - School of Biological Sciences, Monash University

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  infection. Crossing experiments with genetically similar Wolbachia-induced cytoplasmic incompatibility... - bachia-induced cytoplasmic incompatibility in Drosophila. Genetics Turelli, M., 1994 Evolution... albopictus: Accelerating Cytoplasmic Drive Stephen L. Dobson,1 Eric J. Marsland and ...

Source: Dobson, Stephen L. - Department of Entomology, University of Kentucky

Collection: Environmental Sciences and Ecology ; Biotechnology

Summary:  , geranylgeranylace- tone and 17-allylamino-17-demethoxygeldanamycin (17-AAG), have been reported to ameliorate... the phenotype and/or protein aggregation in an SBMA mouse model (74,75). However, 17-AAG has poor blood brain... does not induce Hsp27 activation Alexandra Zourlidou1 , Tali ...

Source: Morimoto, Richard - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

Collection: Biology and Medicine

Summary:  0022112009992187 5 Measurement of cytoplasmic streaming in single plant cells by magnetic resonance velocimetry JAN... transport the cytoplasm along opposing spiralling bands covering the inside of the cell wall, generating... , namely the tonoplast, must transmit efficiently the hydrodynamic shear generated in the cytoplasm

Source: Goldstein, Raymond E. - Department of Applied Mathematics and Theoretical Physics, University of Cambridge

Collection: Physics

Summary:  in light scattering induced by acetic acid in intact cervical cancer cells and cellular components were... contribution to the changes of light scattering induced by acetic acid. The study provided the evidence... that the cellular components of diameter smaller than 0.2 m in the cytoplasm are the major contributors

Source: Qu, Jianan - Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology

Collection: Engineering ; Biology and Medicine

Summary:  ) or in the cytoplasm of dox-induced cells. Scale bar: 5 m. (B) mRNPs (pseudo-colored yellow, center of mass in green... RNA is primed for export, travels to the nuclear envelope and translocates into the cytoplasm (Kohler and Hurt... the nucleoplasm (Shav-Tal et al., 2004) or the cytoplasm (Fusco et al., ...

Source: Singer, Robert H. - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University

Collection: Biology and Medicine

Summary:  FUNCTIONS OF CYTOPLASMIC FIBERS IN INTRACELLULAR MOVEMENTS IN BHK-21 CELLS EUGENIA WANG and ROBERT... into the expanding regions of cytoplasm. Bidirectional saltations are seen along the long axes of fully spread cells... of the type of cytoplasmic streaming seen in amoeboid organisms. The streaming may reflect either the ...

Source: Goldman, Robert D. - Department of Cell and Molecular Biology, Northwestern University

Collection: Biology and Medicine

Summary:  Association of the Membrane Proximal Regions of the and Subunit Cytoplasmic Domains Constrains... cytoplasmic domains with acidic and basic peptides that form an -helical coiled coil caused inactivation of L... 2. Association of these artificial cytoplasmic domains was directly demon- strated. By contrast

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

Collection: Biology and Medicine

Summary:  indi- vidually inducing cell torsions. Cell shape was not altered by the absence of the cytoplasmic... ;11:159­166 DOI: 10.1159/000094052 Cytoskeletal Cytoplasmic Filament Ribbon of Treponema: A Member... in motility-associated structures, cell shape, and other cytoplasmic functions including cell division

Source: Izard, Jacques - Cambridge Science Center

Collection: Biology and Medicine

Summary:  cytoplasm. This decline in poly (A)+ RNA level in host cell cytoplasm was concomitant with intracellular... prolif- eration of T. cruzi amastigotes. Thus, T. cruzi may affect host cell cytoplasmic mRNA stability... that this hemoflagellate parasite induces in cardiomyocytes. Using an in vitro system of mouse ...

Source: Singer, Robert H. - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University

Collection: Biology and Medicine

Summary:  that ACTH induces HuR translocation from the nuclear to the cytoplasmic compartment. Leptomycin B... contribute to ACTH-induced accumulation of HuR in the cytoplasm using co-immunoprecipitation experiments... treatment (Fig 3A and 3B). These results suggest that ACTH-induced increase in ...

Source: Ecole Polytechnique, Centre de mathématiques

Collection: Mathematics

Summary:  to cytoplasmically induced pollen sterility, and solid theoretical reasons for believing this is not the case... J. theor. Biol. (1981) 89,83-129 Cytoplasmic Inheritanceand IntragenomicConflict LEDAMURLASCOSMIDES... inheritance patterns of cytoplasmic genes and the sex chromosomesfromthe ...

Source: Cosmides, Leda - Department of Psychology, University of California at Santa Barbara

Collection: Biology and Medicine

Summary:  of the cell membrane from 10.5 to 3.8, while the high cof is sensitive to cell cytoplasm conductivity changes... (DEP) is a term commonly used to describe the field-induced polarization and translational motion... the concept of membrane cross-linking- induced dielectrophoretic discrimination of bovine red blood cells (b

Source: Chang, Hsueh-Chia - Department of Chemical and Biomolecular Engineering, University of Notre Dame

Collection: Engineering

Summary:  of turbidity for intact calf lenses and for isolated nuclear cytoplasm. In the case of the nuclear cytoplasm... the intensity scattered by the large elements increases very strongly. The opacification of the lens cytoplasm... size of the large scattering elements shows a more substantial increase than in the isolated ...

Source: Washington at Seattle, University of - Structural Informatics Group (SIG)

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

Summary:  of Massachusetts, Amherst, Massachusetts 01003 ABSTRACT The existence of cytoplasmic estrogen receptor... of cytoplasmic ER-IR when the H 222 antibody was used to visualize the receptor. This decrease did not appear... by the particular antibody. Extensive loss of cytoplasmic and cell nuclear ER-IR was seen when an antiserum ...

Source: Blaustein, Jeffrey D. - Center for Neuroendocrine Studies, University of Massachusetts at Amherst

Collection: Biology and Medicine

Summary:  this similarity in the membrane-spanning region, the cytoplasmic regions of the two molecules were very different... components: the first is an inclination of the main cytoplasmic mass by 20° relative to the membrane... -spanning domain; the second is a rearrangement of the domains comprising the cytoplasmic part of the ...

Source: Stokes, David L. - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

Collection: Biology and Medicine

Summary:  /N-cadherin cytoplasmic tail induces the accumulation of cadherins in cell­cell AJ. CHO-Ncad cells expressing IL-2R... /N-cadherin cytoplasmic tail chimera induces the accumulation of -catenin in cell­cell AJ. CHO-Ncad cells expressing IL-2R... Modulation of Cell­Cell Adherens Junctions by Surface Clustering ...

Source: Geiger, Benjamin - Department of Molecular Cell Biology, Weizmann Institute of Science

Collection: Biology and Medicine

Summary:  Xenopus Rbm9 is a novel interactor of XGld2 in the cytoplasmic polyadenylation complex. Catherine... . Abbreviations: PAP, poly(A) polymerase; CPEB, cytoplasmic polyadenylation element- binding protein; Gal4BD, Gal4... DNA binding domain Keywords: Gld2, cytoplasmic polyadenylation, Xenopus oocyte, Rbm9, poly

Source: Ecole Polytechnique, Centre de mathématiques

Collection: Mathematics

Summary:  that the cytoplasm of animal cells is not under pressure is incorrect. If contraction-induced pres- sure can drive... cytoplasm for the dynamics of animal cell shape T.J. Mitchisona,, G.T. Charrasb, L. Mahadevanc a Department... during migration and division of animal cells: the cytoplasm can be modeled as a ...

Source: Mahadevan, L. - School of Engineering and Applied Sciences, Harvard University

Collection: Engineering ; Materials Science

Summary:  that this nonsense codon-induced partitioning shift (NIPS) response is not the result of cytoplasmic NMD but instead... -to-cytoplas- mic fraction mRNA ratio that results in few TCR transcripts escaping to the cytoplasmic fraction... of cells. Analysis of TCR mRNA kinetics after either transcriptional repression or ...

Source: Wilkinson, Miles F. - Department of Reproductive Medicine, University of California at San Diego

Collection: Biology and Medicine

Summary:  . Different fluorescence attenuation rates of the cytoplasm and nucleoplasm were documented... terasaki@neuron.uchc.edu Key words: Cdc2, cell cycle, cytoplasm, fluorescent dextran, germinal vesicle... and in cytoplasm (A) Signal decrease due to increasing concentrations of a fluorescent molecule as described

Source: Terasaki, Mark - Department of Cell Biology, University of Connecticut Health Center

Collection: Biology and Medicine

Summary:  - rial behavior can be induced by alterations in the cytoplasmic domain ofan integral membrane protein... that the deletion ofnine amino acids at thejunction ofthe cytoplasmic and the first transmembrane domain induces... (30). Thus, ligand-induced confor- mational change in the ...

Source: Knowles, David William - Life Sciences Division, Lawrence Berkeley National Laboratory

Collection: Biology and Medicine

Summary:  May 15, 2001) Polarized radial arrays of cytoplasmic microtubules (MTs) with minus ends clustered... at the cell center define the organization of the cytoplasm through interaction with microtubule motors bound... -organization that requires the activity of a minus- end-directed MT motor, cytoplasmic dynein. In this study we ...

Source: Vorobjev, Ivan - Department of Cytology and Histology, Biological Faculty, Moscow State University

Collection: Biology and Medicine

Summary:  , T. Honjo, Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like... APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic Ryan P... , respectively, in the cell nucleus, hA3G mutagenic activity appears to be restricted to the cytoplasm. We

Source: Wedekind, Joseph E. - Department of Biochemistry and Biophysics, University of Rochester

Collection: Biology and Medicine

Summary:  cytoplasm) from the outside. This membrane, the cytoplasmic membrane, has several functions, of which energy... the cytoplasmic membrane. Figure 1. Schematic representation of the cytoplasmic membrane with an embedded... . The cytoplasmic membrane consists of proteins and (phospho)lipids. ...

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  to the forespore-specific promoter PspoIIQ were induced to sporulate by resuspension. The first panel shows... the localization of CFP (false-colored green) in the forespore cytoplasm. The membranes are labeled with TMA

Source: Rudner, David - Department of Microbiology and Molecular Genetics, Harvard University

Collection: Biology and Medicine

Summary:  demonstrate that microarrays detect cellular changes induced by irradiation at doses that are 1000-fold lower... . In this study, we monitored transcriptional changes induced in yeast populations growing in an environment... with and without irradiation. We first estimated the range of doses that induced genetic changes such as ...

Source: Antoniadis, Anestis - Laboratoire Jean Kuntzmann, Université Joseph Fourier

Collection: Mathematics

Summary:  in both wild-type and mutant embryos. However, cytoplasmic PAR protein polarity, which is vital... such a framework. We therefore consider additional mechanisms that can reproduce the proper cytoplasmic polarity... . In particular we predict that cytoskeletal asymmetry in the cytoplasm, in addition to the cortical actomyosin

Source: Howard, Martin - Department of Systems Biology, John Innes Centre

Collection: Physics ; Mathematics

Summary:  1 Dominant mutations in the late 40S biogenesis factor Ltv1 affect cytoplasmic maturation... #12;2 Running Head: LTV1 mutants impede 40S cytoplasmic maturation Key words: ribosome biogenesis, Ltv... in final maturation steps in the cytoplasm. Ltv1 is a conserved 40S ribosome biogenesis factor

Source: Lycan, Deborah E. - Department of Biology, Lewis and Clark College

Collection: Biology and Medicine

Summary:  to the adjacent cytoplasm within human nuclear fiber cells. MLBs have been characterized previously as 1e4 mm... diameter spherical particles covered by multiple lipid bilayers surrounding a cytoplasmic core of variable... and cytoplasm. In this study quantitative values of relative RI were determined from specific MLBs in ...

Source: Johnsen, Sönke - Department of Biology, Duke University

Collection: Biology and Medicine ; Environmental Sciences and Ecology

Summary:  ). The cytoplasmic domain played a crucial role in this process, inasmuch as ligand binding did not induce rigidity... To study the role of the cytoplasmic domain of glycophorin A in ligand-induced rigidification and receptor... not induce immobilization of the hybrid glycoprotein and ...

Source: Knowles, David William - Life Sciences Division, Lawrence Berkeley National Laboratory

Collection: Biology and Medicine

Summary:  and Csk shRNA-transfected HT29 cells. We first study the contribution of the nucleus and the cytoplasm... to the intracellular disorder strength. Our results indicate that both the nucleus and the cytoplasm participate... was to arrive at the minimum concentration and time duration required to induce nanoarchitec- tural ...

Source: Pradhan, Prabhakar - Department of Electrical and Computer Engineering, Northeastern University

Collection: Physics ; Materials Science

Summary:  and axonal function. Here we show that the QNQKE sequence can influence the nucleo- cytoplasmic distribution... - ation of splicing (Sumner, 2006). SMN is localized to both the nucleus and cytoplasm, and considerable... cytoplasmic localization has been largely controversial. Insofar as SMN is involved in snRNP assembly, why

Source: Singer, Robert H. - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Yeshiva University

Collection: Biology and Medicine

Summary:  -based predictions of cytoplasmic concentra- tions of phosphate metabolites (ATP, ADP, and inorganic phosphate... of the cytoplasmic phosphoenergetic com- pounds ATP, ADP, and inorganic phosphate (Pi), oxidative phosphorylation... ), and thermodynamic control involving quasi- linear relations between cytoplasmic Gibbs free energy ...

Source: Medical College of Wisconsin, Biotechnology and Bioengineering Center, Computational Bioengineering Group

Collection: Biology and Medicine

Summary:  , allow- ing visualization of both cytoplasmic and spindle micro- tubules, and does not interfere... microtubules are modulated during the cell cycle. The behavior of cytoplasmic mi- crotubules revealed distinct... and anucleate cells because of the failure of the spindle to elongate through the neck. Cytoplasmic dynein

Source: Stearns, Tim - Departments of Biology & Genetics, Stanford University

Collection: Biology and Medicine

Summary:  expression of a subset of the PIKKs, as treating cells with the Hsp90 inhibitor 17-AAG results in loss of Atr... and 2A mutant of TEL2 exhibited similar subcellular localization, with higher abundance in the cytoplasm... -expressing cells with the pTEL2 antibody gave predominantly cytoplasmic staining, with a ...

Source: de Lange, Titia - Laboratory for Cell Biology and Genetics, Rockefeller University

Collection: Biology and Medicine

Summary:  in a competition assay to inhibit the CIB-induced F of the full-length IIb cytoplasmic domain peptide. However... Molecular Basis of CIB Binding to the Integrin IIb Cytoplasmic Domain* Received for publication... to be regulated by molecules that bind to their cytoplasmic domains. We previously identified a ...

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

Collection: Biology and Medicine

Summary:  filament networks suggests that nonthermal forces driven by the motor protein myosin II can induce large... , using high-resolution particle tracking, we find that thermal forces, not myosin-induced fluctuating... of nanoparticles lodged in the cytoplasm, reveal the biphasic mechanical architecture of adherent cells

Source: Sun, Sean - Department of Mechanical Engineering, Johns Hopkins University

Collection: Engineering ; Biotechnology