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Sample records for amphetamine methamphetamine mda

  1. Mechanisms of neurotransmitter release by amphetamines: A review David Sulzer a,b,*, Mark S. Sonders b,c

    Biology and Medicine Websites

    Sulzer, David

    Mechanisms of neurotransmitter release by amphetamines: A review David Sulzer a,b,*, Mark S 37232, USA Received 22 December 2004; accepted 18 April 2005 Abstract Amphetamine and substituted amphetamines, including methamphetamine, methylphenidate (Ritalin), methylenedioxymethampheta- mine (ecstasy

  2. From Made in America to Hecho en Sinaloa: A Historical Geography of North American Methamphetamine Networks

    University of Kansas - KU ScholarWorks

    Gilbreath, Aaron Hastings

    2012-08-31

    treatment for amphetamine abuse in 1976 and 1980 according to the Client Oriented Data Acquisition Program 90 Figure 3.2: Territory of the Big Four Motorcycle Gangs in....3: Methamphetamine trafficking routes identified in the National Drug Threat Assessment: 2011 152 Figure 44: Methamphetamine lab seizures in Mexico 153 Figure 4.5: Seizures by...

  3. Methamphetamine Induces Chronic Corticostriatal Depression

    Biology and Medicine Websites

    Sulzer, David

    Methamphetamine Induces Chronic Corticostriatal Depression: Too Much of a Bad Thing Jeremy J. Day1-releasing psychostimu- lant methamphetamine alters neurotrans- mission at corticostriatal synapses. Imag- ing

  4. Running head: BOUNDARY CONDITIONS OF METHAMPHETAMINE CRAVING Boundary Conditions of Methamphetamine Craving

    Biology and Medicine Websites

    Ochsner, Kevin

    Running head: BOUNDARY CONDITIONS OF METHAMPHETAMINE CRAVING Boundary Conditions of Methamphetamine #12;BOUNDARY CONDITIONS OF METHAMPHETAMINE CRAVING 2 Abstract Methamphetamine use has increased significantly and become a global health concern. Craving is known to predict methamphetamine use and relapse

  5. Methamphetamine's Effect on the Brain and Behavior

    Biology and Medicine Websites

    California at San Diego, University of

    1 Methamphetamine's Effect on the Brain and Behavior Martin P Paulus University of California San and behavioral dysfunction in methamphetamine 1. Neural substrates 1. Anterior cingulate 2. Orbitofrontal cortex of relapse in methamphetamine dependent individuals Methamphetamine ­ Blocking Reuptake of Dopamine What Does

  6. ORIGINAL ARTICLE Neural Activation Patterns of Methamphetamine-

    Biology and Medicine Websites

    California at San Diego, University of

    ORIGINAL ARTICLE Neural Activation Patterns of Methamphetamine- Dependent Subjects During Decision abuse or dependence.1 Among these, the prevalence with methamphetamine- related problems has more than doubled between 1991 and 1998.1 Worldwide, more than 40 million people have used methamphetamine and other

  7. Development/Plasticity/Repair Differentiating Prenatal Exposure to Methamphetamine and

    Biology and Medicine Websites

    Thompson, Paul

    Development/Plasticity/Repair Differentiating Prenatal Exposure to Methamphetamine and Alcohol versus Alcohol and Not Methamphetamine using Tensor-Based Brain Morphometry and Discriminant Analysis of prenatal exposure to methamphetamine (MA) on local brain volume using magnetic resonance imaging. Because

  8. Behavioral Neuroscience Amphetamine-Induced Sensitization and Reward

    Biology and Medicine Websites

    Berridge, Kent

    amphetamine sensitization or repeated restraint stress interact with uncertainty in controlling CS incentive, different groups underwent either induction of amphetamine sensitization or repeated restraint stress by either manipulation alone. In contrast, repeated restraint stress enhanced subsequent amphetamine

  9. Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP

    Biology and Medicine Websites

    Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans 13 June 2005 Available online 20 July 2005 Abstract Pyrolytic products of smoked methamphetamine; Methamphetamine; Pyrolysis Introduction Methamphetamine hydrochloride is a popular illicit drug that is abused

  10. DETECTION & MAPPING OF ABNORMAL BRAIN STRUCTURE IN METHAMPHETAMINE USERS

    Biology and Medicine Websites

    Thompson, Paul

    DETECTION & MAPPING OF ABNORMAL BRAIN STRUCTURE IN METHAMPHETAMINE USERS 1 P.M. Thompson, 1 K of Medicine, Los Angeles CA 90095 We detected a pattern of brain structure deficits in chronic methamphetamine surface vertex, we fitted a general linear model to assess methamphetamine effects on gray matter density

  11. Amphetamine-Induced Displacement of [18 F] Fallypride

    Biology and Medicine Websites

    Park, Sohee

    Amphetamine-Induced Displacement of [18 F] Fallypride in Striatum and Extrastriatal Regions This study examined D-amphetamine (D-AMPH)-induced displacements of [18 F] fallypride in striatal; amphetamine challenge; humans #12;#12; #12; #12; #12; #12; #12; #12; #12; #12; #12; #12; #12; #12; #12; #12

  12. Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis

    Biology and Medicine Websites

    Sulzer, David

    Methamphetamine (Meth) is abused by over 35 million people worldwide. Chronic Meth abuse may be particularly specific evidence that Meth at pharmacological concentrations exerts a direct immunosuppressive effect on dendritic cells and macrophages. As a weak base, Meth collapses the pH gradient across acidic organelles

  13. Amphetamine Distorts Stimulation-Dependent Dopamine Overflow: Effects on D2 Autoreceptors, Transporters, and Synaptic

    Biology and Medicine Websites

    Sulzer, David

    Amphetamine Distorts Stimulation-Dependent Dopamine Overflow: Effects on D2 Autoreceptors York 10032, and 4Universite´ Victor Segalen, Bordeaux 33076, France Amphetamine (AMPH) is known sensitization. Key words: dopamine; amphetamine; uptake; amperometry; cyclic voltammetry; D2 receptor

  14. SYSTEMIC AND INTRA-ACCUMBENS ADMINISTRATION OF AMPHETAMINE DIFFERENTIALLY AFFECTS CORTICAL ACETYLCHOLINE RELEASE

    Biology and Medicine Websites

    Bruno, John P.

    SYSTEMIC AND INTRA-ACCUMBENS ADMINISTRATION OF AMPHETAMINE DIFFERENTIALLY AFFECTS CORTICAL experiments tested the hypothesis that the amphetamine-induced increase in dopamine release in the nucleus amphetamine to stimulate cortical acetylcholine release. The effects of systemic or intra

  15. Migrating a Domain-Specific Modeling Infrastructure to MDA Technology

    Computer Technologies and Information Sciences Websites

    van Deursen, Arie

    Migrating a Domain-Specific Modeling Infrastructure to MDA Technology Duncan Doyle1,2, Hans Geers2 be migrated to models conform the MDA, in order to benefit from the range of MDA standards. We describe the legacy model-driven engineering infrastructure, propose a migration approach, discuss how we implemented

  16. Differential interactions of desipramine with amphetamine and methamphetamine: Evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex

    University of California eScholarship Repository

    Shoblock, James R; Maisonneuve, I M; Glick, S D

    2004-01-01

    At the end of the experiment, animals were anesthetized withthe start of the experiments were used. Animals were groupexperiments were carried out in accordance with the NIH Guide for the Care and Use of Laboratory Animals and

  17. Methamphetamine self-administration in rats developmentally exposed to lead 

    Texas A&M University - TxSpace

    Rocha, Angelica

    2009-05-15

    of abuse (e.g., cocaine, opiates) across the phases of initial selection, use, and abuse. Lead-induced changes in sensitivity to methamphetamine have not been examined in animals perinatally exposed to lead. Accordingly, four studies were conducted...

  18. Harvesting Software Systems for MDA-Based Reengineering

    Computer Technologies and Information Sciences Websites

    van Deursen, Arie

    system from the insurance do- main written in PL/SQL. 1 Introduction Model Driven Architecture (MDA a reengineering approach which switches to the MDA "technological space" [15] as quickly as possible, after which in this paper was carried out within a pilot study con- ducted at a major Dutch insurance company. The objective

  19. Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression

    Biology and Medicine Websites

    Sulzer, David

    Neuron Article Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal identified. We report that exposure to the dopamine releaser methamphetamine for 10 days elicits a long-lasting (>4 month) depression at corticostriatal terminals that is reversed by methamphetamine readmin

  20. ELSEVIER Physiology & Behavior 71 (2000) 95-106 Long T methamphetamine schedules produce circadian ensuing drug

    Biology and Medicine Websites

    Timberlake, William D.

    2000-01-01

    PHYSIOLOGY & BEHAVIOR ELSEVIER Physiology & Behavior 71 (2000) 95-106 Long T methamphetamine schedule. Following 2 months of free-running activity, all animals were administered methamphetamine (MA) i. Keywords: Methamphetamine; Circadian ensuing drug activity; Long T schedules; Type O resetting

  1. Digital MDA for enumeration of total nucleic acid contamination

    Biotechnology Websites

    Quake, Stephen R.

    ; Accepted October 14, 2010 ABSTRACT Multiple displacement amplification (MDA) is an iso- thermal, sequence-displacement synthesis activity of f29 DNAP, has revolutionized analyses of small-quantity DNA samples by providing

  2. Tools for MDA Software Development: Evaluation Criteria and Set of Desirable Features

    Computer Technologies and Information Sciences Websites

    Dascalu, Sergiu

    requirements the "portrait" of an ideal MDA tool. 1. Introduction MDA is currently one of the most challenging presents the "portrait" of an ideal MDA tool; Section 6 outlines related research work, and, finally

  3. Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior in Mice

    Biology and Medicine Websites

    California at San Diego, University of

    Strain-Specific Effects of Amphetamine on Prepulse Inhibition and Patterns of Locomotor Behavior of locomotor activity, two behavioral processes that are altered by dopamine (DA) agonists such as amphetamine and in amphetamine dose-response studies. Because hearing loss is common in numerous strains of mice, we also

  4. ORIGINAL INVESTIGATION The effects of yohimbine and amphetamine on fear

    Biology and Medicine Websites

    Quirk, Gregory J.

    ORIGINAL INVESTIGATION The effects of yohimbine and amphetamine on fear expression and extinction Rationale Psychostimulants, such as yohimbine and am- phetamine, can enhance learning and memory. Extinction. Previous work suggests that yohimbine facilitates extinction, using freezing as a fear measure. However

  5. Early life tactile stimulation changes adult rat responsiveness to amphetamine

    Environmental Sciences and Ecology Websites

    Sokolowski, Marla

    have found that total maternal deprivation of rat pups, achieved through artificial rearing, leads, associated with artificial rearing, by examining the locomotor stimulant effects of the dopamine releaser amphetamine and the dopamine reuptake inhibitor methylphenidate. Rats were mother-reared or artificially

  6. Towards an MDA-based development methodology for distributed applications

    Computer Technologies and Information Sciences Websites

    Pires, Luís Ferreira

    71 Towards an MDA-based development methodology for distributed applications Anastasius Gavras1,alme}@ewi.utwente.nl Abstract This paper proposes a development methodology for distributed applications based on the principles- based development trajectory, and defines the roles and products of each activity in accordance

  7. LAMP-TR-*** MDA 9049-6C-1250

    Computer Technologies and Information Sciences Websites

    DeMenthon, Daniel

    LAMP-TR-*** CAR-TR-*** CS-TR-**** MDA 9049-6C-1250 September 2000 Hidden Markov Models for Images Daniel DeMenthon, Marc Vuilleumier and David Doermann #12;Hidden Markov Models for Images Daniel De of images using a second-order hidden Markov mesh model. We show that the Viterbi algorithm approach used

  8. Methamphetamine use and infectious disease-related behaviors in men who have sex with men: implications for interventions

    University of California eScholarship Repository

    Shoptaw, S; Reback, C J

    2007-01-01

    of recreational use of methamphetamine and other club drugsrecreational levels to reduce or eliminate methamphetamine their drugrecreational to chronic to addiction, however, the data consistently indicate that MSM who use this drug

  9. The Journal of Neuroscience, April 1994, 74(4): 2260-2271 Methamphetamine Neurotoxicity Involves Vacuolation of Endocytic

    Biology and Medicine Websites

    Sulzer, David

    The Journal of Neuroscience, April 1994, 74(4): 2260-2271 Methamphetamine Neurotoxicity Involves of Neuropathology, New York State Psychiatric Institute, New York, New York 10032 Methamphetamine (MA) produces

  10. ELSEVIER N.eurosc;:ience Letters 250 (1998) 99-102 Circadian activity precedes daily methamphetamine injections

    Biology and Medicine Websites

    Timberlake, William D.

    1998-01-01

    methamphetamine injections in the rat Ann E.K. Kosobuda.*, Norman C. Pecorarob, George V. Rebeca, William 1998 Abstract Scheduled daily injections of methamphetamine (MA) produced locomotor activity. In the present study, we tested whether daily administration of methamphetamine (MA) could trigger cir- cadian

  11. D-amphetamine stimulates unconditioned exploration/approach behaviors in cray sh: Towards a conserved evolutionary function of ancestral drug reward

    Environmental Sciences and Ecology Websites

    Huber, Robert

    D-amphetamine stimulates unconditioned exploration/approach behaviors in cray sh: Towards 2 April 2011 Available online 12 April 2011 Keywords: Amphetamine Addiction Invertebrate Reward administration. The present work demonstrates that the administration of D-amphetamine stimulates active

  12. Incorporating Agile with MDA Case Study: Online Polling System

    CERN Preprints

    Guha, Pritha; Shukla, Shiv Shankar Prasad; Singh, Shweta; 10.5121/ijsea.2011.2408

    2011-01-01

    Nowadays agile software development is used in greater extend but for small organizations only, whereas MDA is suitable for large organizations but yet not standardized. In this paper the pros and cons of Model Driven Architecture (MDA) and Extreme programming have been discussed. As both of them have some limitations and cannot be used in both large scale and small scale organizations a new architecture has been proposed. In this model it is tried to opt the advantages and important values to overcome the limitations of both the software development procedures. In support to the proposed architecture the implementation of it on Online Polling System has been discussed and all the phases of software development have been explained.

  13. Preprint Collection of Charles J. Wilson Amphetamine-induced release of dopamine from the substantia nigra in vitro

    Biology and Medicine Websites

    Wilson, Charles J.

    Preprint Collection of Charles J. Wilson p. 1 Amphetamine-induced release of dopamine from of chopped tissue from the substantia nigra of the rat brain with d-amphetamine resulted in a significant of amphetamine produces a marked inhibition of neuronal activity in pars compacta of the substantia nigra (1

  14. Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers

    Biology and Medicine Websites

    Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy online 8 February 2005 Abstract Background: Recent research on schizophrenia indicates that cognitive administration of d-amphetamine can improve cognitive function in individuals with schizophrenia who are well

  15. MDA based-approach for UML Models Complete Comparison

    CERN Preprints

    Chaouni, Samia Benabdellah; Mouline, Salma

    2011-01-01

    If a modeling task is distributed, it will frequently be necessary to integrate models developed by different team members. Problems occur in the models integration step and particularly, in the comparison phase of the integration. This issue had been discussed in several domains and various models. However, previous approaches have not correctly handled the semantic comparison. In the current paper, we provide a MDA-based approach for models comparison which aims at comparing UML models. We develop an hybrid approach which takes into account syntactic, semantic and structural comparison aspects. For this purpose, we use the domain ontology as well as other resources such as dictionaries. We propose a decision support system which permits the user to validate (or not) correspondences extracted in the comparison phase. For implementation, we propose an extension of the generic correspondence metamodel AMW in order to transform UML models to the correspondence model.

  16. Duration of detection of methamphetamine in hair after abstinence Natiprada Suwannachom a

    Mathematics Websites

    O'Brien, Timothy E.

    into the detection of use. However, in the terminology of drug abuse research, ``abstinence'' does not mean merely by legal or medical authorities [5,6]. Since the beginning of the twenty-first century, methamphetamine (MA

  17. Persistent Reversal of Enhanced Amphetamine Intake by Transient CaMKII Inhibition

    MIT - DSpace

    Loweth, Jessica A.

    Amphetamine exposure transiently increases Ca2+/calmodulin-dependent protein kinase II (CaMKII) ? expression in the nucleus accumbens (NAcc) shell and this persistently increases local GluA1 S831 phosphorylation and enhances ...

  18. Evaluating the Use of AOP and MDA in Web Service Development

    Computer Technologies and Information Sciences Websites

    Bordbar, Behzad

    Evaluating the Use of AOP and MDA in Web Service Development Guadalupe Ortiz Quercus Software-Oriented Programming (AOP) is motivated by the need to create decoupled systems, which are easier to maintain. As a result, it can be argued that adopting AOP and MDA side- by-side will provide advantages from both sets

  19. ARQUITECTURAS DE SISTEMAS DE INFORMAO E A INICIATIVA MDA MARCO COSTA*

    Computer Technologies and Information Sciences Websites

    da Silva, Alberto Rodrigues

    ARQUITECTURAS DE SISTEMAS DE INFORMAÇÃO E A INICIATIVA MDA MARCO COSTA* e ALBERTO RODRIGUES DA Management Group MDA approach and two concrete initiatives, Codagen and XIS. RESUMO A Arquitectura de comparação e discussão entre diversas abordagens existentes para a formalização de arquitecturas de sistemas

  20. Middleware Transparent Software Development & the MDA Devon Simmonds, Sudipto Ghosh, Robert France

    Computer Technologies and Information Sciences Websites

    Simmonds, Devon M.

    significant growth and maturation over the last four decades of the 20th century. This growth and maturation of middleware technologies and the pervasiveness of distributed systems. The Model Driven Architecture (MDA, MDA, middle- ware, Jini, CORBA, AOSD. 1 Introduction The software development industry has seen

  1. Mechanism of MDA5 Recognition of Short RNA Ligands and Crystal Structure of PepQ 

    Texas A&M University - TxSpace

    Watts, Tylan Aubrey

    2013-05-16

    electrophoresis. In addition, structural data was gathered by crystallization of the MDA5 RD-RNA complex using X-ray crystallography. These results help to establish the manner in which MDA5 is regulated predominantly to the binding of long RNA ligands. Also...

  2. MDA: A Formal Approach to Game Design and Game Research Robin Hunicke, Marc LeBlanc, Robert Zubek

    Computer Technologies and Information Sciences Websites

    Horswill, Ian

    present the MDA framework (standing for Mechanics, Dynamics, and Aesthetics), developed and taught as part the MDA framework (standing for Mechanics, Dynamics, and Aesthetics), developed and taught as part and scholars perform this translation. MDA Games are created by designers/teams of developers, and consumed

  3. Program Description The Minnesota Department of Agriculture's (MDA) Certified Soil Testing

    Environmental Sciences and Ecology Websites

    Minnesota, University of

    Program Description The Minnesota Department of Agriculture's (MDA) Certified Soil Testing Laboratory Program actively promotes the use of laboratory soil testing and helps laboratories maintain quality assurance. History Farmers rely on soil laboratory tests to determine appropriate fertilizer

  4. D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model

    Biology and Medicine Websites

    Pike, Victor W.

    D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine Arrestin3 PET Dopamine released by amphetamine decreases the in vivo binding of PET radioligands to 2 h after amphetamine treatment, radioligand binding remains decreased for several hours

  5. Methamphetamine-Induced Degeneration of Dopaminergic Neurons Involves Autophagy and Upregulation of

    Biology and Medicine Websites

    Sulzer, David

    and Physiology, University of California, San Francisco, California 94143 Methamphetamine (METH) selectively that METH-induced redistribution of DA from the vesicular storage pool to the cytoplasm, where DA can into synaptic vesicles. In postnatal ventral midbrain neuro- nal cultures derived from these mice, METH

  6. MDA-based Approach for Embedded Software Generation from a UML/MOF Repository

    Computer Technologies and Information Sciences Websites

    Wagner, Flávio Rech

    from specification to implementation is made using a mapping model specified in terms of modelMDA-based Approach for Embedded Software Generation from a UML/MOF Repository 1 Francisco A. M. do Alegre, Brazil cpereira@ece.ufrgs.br ABSTRACT This work presents a UML/MOF meta-modeling infrastructure

  7. Applying MDA to the Development of Data Warehouses Jose-Norberto Mazn, Juan Trujillo

    Computer Technologies and Information Sciences Websites

    Song, Il-Yeol

    Applying MDA to the Development of Data Warehouses Jose-Norberto Mazón, Juan Trujillo Dept of a data warehouse (DW) system. However, they are all partial solutions which deal with isolated aspects. Categories and Subject Descriptors H.2.7 [Database management]: Database Administration ­ Data warehouse

  8. Towards an MDA-based development methodology1 Anastasius Gavras1

    Computer Technologies and Information Sciences Websites

    Pires, Luís Ferreira

    Towards an MDA-based development methodology1 Anastasius Gavras1 , Mariano Belaunde2 , Luís. This paper proposes a development methodology for distributed applications based on the principles- based development trajectory, and defines the roles and products of each activity in accordance

  9. Effects of Methamphetamine Administration on Information Gathering during Probabilistic Reasoning in Healthy Humans

    University of Cambridge - Dspace

    Ermakova, Anna O.; Ramachandra, Pranathi; Corlett, Philip R.; Fletcher, Paul C.; Murray, Graham K.

    2014-07-25

    disorders gave written informed consent and were included in the study. Participants attended on three visits, separated by at least 1 week. In one visit, they received an intravenous infusion over 10 minutes with a methamphetamine solution (0.3 mg... ) approximately 1 hour before the infusion. In the third visit, they received a saline infusion and a placebo tablet. The order of the visits was pseudorandomized for each participant in a counterbalanced manner. Participants, researchers who administered...

  10. Methamphetamine-induced dopamine terminal deficits in the nucleus accumbens are exacerbated by reward-associated cues and attenuated by CB1

    Biology and Medicine Websites

    Cheer, Joseph F.

    Keywords: Methamphetamine Dopamine Endocannabinoids Voltammetry a b s t r a c t Methamphetamine (METH have implicated the endocannabinoid system in METH's locomotor, rewarding and neurochemical effects, a role for this signaling system in METH's effects on dopamine terminal dynamics has not been elucidated

  11. MDA-based ATL transformation to generate MVC 2 web models

    CERN Preprints

    Rahmouni, M'hamed

    2011-01-01

    Development and maintenance of Web application is still a complex and error-prone process. We need integrated techniques and tool support for automated generation of Web systems and a ready prescription for easy maintenance. The MDA approach proposes an architecture taking into account the development and maintenance of large and complex software. In this paper, we apply MDA approach for generating PSM from UML design to MVC 2Web implementation. That is why we have developed two meta-models handling UML class diagrams and MVC 2 Web applications, then we have to set up transformation rules. These last are expressed in ATL language. To specify the transformation rules (especially CRUD methods) we used a UML profiles. To clearly illustrate the result generated by this transformation, we converted the XMI file generated in an EMF (Eclipse Modeling Framework) model.

  12. WANG et al.: CLASSIFICATION BASED MDA PREDICTION FOR SCALABLE VIDEO CODING USING SUBJECTIVE QUALITY 1 Abstract -Scalable video coding offers a flexible representation

    Computer Technologies and Information Sciences Websites

    Chang, Shih-Fu

    categories within which the videos share similar preferred MDA operations. Thereafter, a machine learningWANG et al.: CLASSIFICATION BASED MDA PREDICTION FOR SCALABLE VIDEO CODING USING SUBJECTIVE QUALITY framework for selecting the preferred MDA operations based on subjective quality evaluation

  13. CHEM-L CHildren Exposed to Methamphetamine Laboratories Flowsheet Side 1 Version 4.0 January 20, 2004

    Engineering Websites

    Farritor, Shane

    before, during, and after a child is found in association with a clandestine methamphetamine laboratory in Nebraska. Law Enforcement EMS/Fire Activate protocol when child exposure is possible ·Treat threats to life & decontaminate Brief HHSS when advance notice is possible ---- At the Scene ---- ·Take child into protective

  14. Modern Realities of the 'Jurisdictional Maze' in Indian Country: Case Studies on Methamphetamines Use and the Pressures to Ensure Homeland Security

    University of Kansas - KU ScholarWorks

    Kronk, Elizabeth Ann; Thompson, Heather Dawn

    2007-01-01

    , amounting to a "jurisdictional maze." Problems that arise from modern developments, such as increased use of methamphetamine (meth) and the pressures of ensuring homeland security, become exacerbated when combined with the often perplexing realities...

  15. The Journal of Neuroscience, May 1995, 15(5): 4102-4108 Amphetamine Redistributes Dopamine from Synaptic Vesicles to

    Biology and Medicine Websites

    Sulzer, David

    Synaptic Vesicles to the Cytosol and Promotes Reverse Transport David SuIzer,1.21415Ta-Kung Chen,`j Yau Yi it redistributes dopamine to the cytosol, promoting reverse transport, and dopamine release. [Key words: amphetamine, reverse transport, synaptic vesicles, PC72 cc//s, Planorbis corneus, amperometry

  16. Location, location: using functional magnetic resonance imaging to pinpoint brain differences

    Biology and Medicine Websites

    California at San Diego, University of

    in methamphetamine and cocaine-dependent individuals. Methods We reviewed all publications in PubMed that conducted comparison studies between healthy volunteers and cocaine-, amphetamine- or methamphetamine-mail: mpaulus@ucsd.edu INTRODUCTION Methamphetamine and cocaine dependence are brain disorders characterized

  17. *Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, NY, USA

    Biology and Medicine Websites

    Sulzer, David

    Institute, New York, NY, USA Amphetamine (AMPH) and methamphetamine (METH) have been prescribed to over 19; METH, methamphetamine; PBS, phosphate-buffered saline; RT, room temperature. Abstract Acute exposure and methamphetamine (METH), however, are retained in tissues over long durations. We used optical and electron

  18. Neuron, Vol. 5, 797-808, December, 1990, Copyright 0 1990 by Cell Press Amphetamine and Other Psychostimulants Reduce pH

    Biology and Medicine Websites

    Sulzer, David

    uptake and/or increased release of dopamine at mesolimbic synapses. As exemplified by cocaine, many as well as cocaine and phencyclidine rapidly reduced pH gradients in cul- tured midbrain dopaminergic the rewarding effects of psychostimulants (Koob and Bloom, 1988). Amphetamine, cocaine, phencyclidine, and other

  19. Fenfluramine hydrochloride, (+-)-N-ethyl-m-(trifluoromethyl)amphetamine hydrochloride

    University of Kansas - KU ScholarWorks

    Grunewald, Gary L.; Creese, Mary W.; Extine, Michael W.

    1981-01-01

    , International Union of Crystallography, 5 Abbey Square, Chester CHI 2HU, England 056 7-7408/81 /091790-04S01.00 ©1981 International Union o f Crystal lography FENFLURAMINE HYDROCHLORIDE 1791 H2 Fig. 1. Molecular structure and atom-numbering system...) bromination of steroidal ketones. Ambiguities in the interpretation of IR, UV, NMR and mass-spectral data, as well as the interpretation of ORD curvest for compounds (III) and (IV) (Fig. 1), prompted us to turn to X-ray crystallography for the positive...

  20. Methamphetamine and Tribal Criminal Jurisdiction on the Wind River Reservation

    University of Kansas - KU ScholarWorks

    Cisneros, Mandy

    2008-06-18

    ????.?..?????????...??????.???5 Chapter One: Overview of the ?Meth? Epidemic on the Wind River Reservation?????6 A. What is ?Meth??......................................................................................................6 B. Effects of Drug on User...???..???????????..???...???...9 C. Effects of Drug on Tribal Community??????..?...?..????...??10 D. Influx of Meth on to the Wind River Reservation????...????...??..16 Chapter Two: Review of Tribal Criminal Jurisdiction.....??????????????20 A. Development of U.S. Indian...

  1. Research paper Engineering of recombinant antibody fragments to methamphetamine

    Biotechnology Websites

    Georgiou, George

    Biology, University of Texas, Austin, TX, United States b Department of Chemistry and Biochemistry, University of Texas, Austin, TX, United States c Department of Chemical Engineering, University of Texas, Austin, TX, United States d Department of Biomedical Engineering, University of Texas, Austin, TX, United

  2. MDA Employed in a Joint eGovernment Strategy: An Experience Report

    Computer Technologies and Information Sciences Websites

    Gogolla, Martin - Fachbereich 3

    , and Alexander Salomon 4 1 University of Bremen, Computer Science Department, Database Systems Group {green techniques. Several similar projects have been started under the roof of DOL as well. The model

  3. A MDA approach for defining WS-Policy semantic non-functional properties

    CERN Preprints

    Belouadha, Fatima-Zahra; Roudies, Ounsa

    2012-01-01

    A lot of works has been especially interested to the functional aspect of Web services. Nevertheless, it is necessary to describe their non-functional properties such as the security characteristics and the quality of service. The WS-Policy standard was recommended in 2007 to describe Web services policies including the non-functional properties. However, it doesn't provide any information of their meaning necessary for automatic processes. In this paper, we propose a Model Driven Architecture approach founded on W3C standards to generate WSDL language based files including semantic policies. We use a package of WSDL and WS-Policy profiles and transformations rules to generate Web services interfaces files including policies. We extend a XML schema profile according to SAWSDL standard to define semantic non-functional properties domains. This work contributes to minimize the development cost of Web services including semantic policies. Moreover, the generated services can be automatically processed in discove...

  4. MDA and Analysis of Web Applications Behzad Bordbar and Kyriakos Anastasakis

    Computer Technologies and Information Sciences Websites

    Bordbar, Behzad

    , the ADI model is automatically transferred to an Alloy model and analysed using the Alloy Analyser. 1 be translated to a model in Alloy [8] and analysed by the Alloy Analyser [17]. We have implemented the transformation from the UML to Alloy in a tool called UML2Alloy [18, 19]. The paper is organised as follows

  5. The University of Alabama in Huntsville MDA MiDAESS Partners

    Computer Technologies and Information Sciences Websites

    Alabama in Huntsville, University of

    Strategic Planning & Financial Management Support Computer Sciences Corporation HQ0147-10-D-0019 Integration Synchronization Engineering Support (Capability Group 3) ERC, Inc. HQ0147-10-D-0006 System Engineering Integration Sensor Engineering General Test Support Computer Sciences Corporation HQ0147-10-D-0008 System Engineering

  6. Requirements Capture and Specification for Enterprise Applications: an MDA compliant attempt

    Computer Technologies and Information Sciences Websites

    Choppy, Christine

    applications that combines the use of the structural concepts provided by the Michael Jackson's problem frames to tackle with a first #12; structuring of problems. Problem frames differ by their requirements, domain should be given ``for free''. While the structuring concepts brought by problem frames seem highly

  7. Requirements Capture and Specification for Enterprise Applications: an MDA compliant attempt

    Computer Technologies and Information Sciences Websites

    Choppy, Christine

    applications that combines the use of the structural concepts provided by the Michael Jackson's problem frames with a first #12;structuring of problems. Problem frames differ by their requirements, domain characteristics". While the structuring concepts brought by problem frames seem highly valuable to help start the devel

  8. 2007-01-3190 Microbial Detection Array (MDA), a Novel Instrument for

    Chemistry Websites

    Kounaves, Samuel P.

    composition between the two otherwise identical chambers. Both chambers are filled with identical autoclave-sterilized, sample-water mixtures. Only one of the chambers receives an additional minute, non-sterilized inoculation the capability to receive two equal mass, homogenized geological samples, provide sterilization through

  9. Evolution of MDA-5/RIG-I-dependent innate immunity: Independent evolution by domain grafting

    Biology and Medicine Websites

    DeSalle, Rob

    components in antiviral innate immunity. Classically, a Toll-like receptor-dependent path- way induces type I (13, 14). Targeted-gene-disruption studies indi- cate that Toll-like receptors (TLRs) recognize molecules to the cytoplas- mic Toll-IL-1 receptor domain of the TLR (19). The adaptors MyD88, IL-1 receptor

  10. Neuroscience Letters 384 (2005) 198202 Cocaine-and amphetamine-regulated transcript (CART) peptide

    Biology and Medicine Websites

    Hall, Randy A

    2005-01-01

    - tion of voltage-gated calcium signaling [17]. Also, injection of CART 55­102 into the lateral ventricles has been found to cause an increase in c-Fos levels in a variety of neurons [14]. In an effort

  11. Neuron, Vol. 43, 261269, July 22, 2004, Copyright 2004 by Cell Press Amphetamine Modulates Human

    Biology and Medicine Websites

    Knutson, Brian

    incentives in humans us-2 Laboratory for Clinical Studies ing fMRI, including characterization of brain responsesNational Institute on Alcohol Abuse and Alcoholism to injections of cocaine (Breiter et al., 1997 and Brain Disorders Branch fMRI does not directly provide information aboutNational Institute of Mental

  12. Individual differences in schizotypal personality traits correlate with amphetamine induced dopamine release in striatal and

    Biology and Medicine Websites

    Park, Sohee

    , Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN. 2Department of Psychology, Vanderbilt University, Nashville, TN. 3Vanderbilt University Institute of Imaging Sciences, Vanderbilt spectrum disorders. Address Correspondence to: Neil D. Woodward, Ph.D., Assistant Professor of Psychiatry

  13. Genome-Wide Association Study of d-Amphetamine Response in Healthy Volunteers Identifies Putative

    Computer Technologies and Information Sciences Websites

    Singh, Jaswinder Pal

    Associations, Including Cadherin 13 (CDH13) Amy B. Hart1. , Barbara E. Engelhardt1,2. , Margaret C. Wardle3 be more tractable than clinical diagnoses. Citation: Hart AB, Engelhardt BE, Wardle MC, Sokoloff G; Accepted July 11, 2012; Published August 28, 2012 Copyright: ß 2012 Hart et al. This is an open

  14. Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered "Wanting" for Sucrose Reward

    Biology and Medicine Websites

    Berridge, Kent

    sensitization; addiction; cue; Pavlovian; instrumental; do- pamine; incentive salience; reward; conditioned reinforcement In addicts, encounters with drug cues can trigger compulsive drug-seeking behavior even after long-sensitization theory of addiction suggests that neural sensitization in mesolimbic-related systems is needed to explain

  15. HIV, Sexually Transmitted Infections and Sexual Risk among Women who Use Methamphetamine

    University of California eScholarship Repository

    Lorvick, Jennifer J.

    2011-01-01

    computer-based personal interviewing system (Blaise®, Westat). Biological testing included HIV, syphilis, herpes simplex viruscomputer-based personal interviewing system (Blaise®,Westat). Biological testing included HIV, syphilis, herpes simplex virus

  16. A Spatial Analysis of Methamphetamine Lab Seizures for Jefferson County, Mo

    University of Kansas - KU ScholarWorks

    Gilbreath, Aaron Hastings

    2010-11-18

    A Spatial Analysis of Mh h i LbSiMethamp etam ne Lab Seizures for Jefferson County, Mo A Gilb haron reat Ph.D. Candidate Department of Geography University of Kansas Photo courtesy of crystalmethaddiction.org Image...A Spatial Analysis of Mh h i LbSiMethamp etam ne Lab Seizures for Jefferson County, Mo A Gilb haron reat Ph.D. Candidate Department of Geography University of Kansas Photo courtesy of crystalmethaddiction.org Image...

  17. Methamphetamine Using Mothers: Perceptions of Prepregnancy Sexual Risks, Recognizing Unintended Pregnancy, and Engaging in the Pregnancy

    University of California eScholarship Repository

    Stemmler, Margaret Susan

    2012-01-01

    in pregnancy that focused on prenatal vitamins, eating ?vitamins and iron supplements, and ?papers? about ?how your body changes? in pregnancy.pregnancy even before their arrest. Almost uniformly, the participants reported that they took prenatal vitamins

  18. Decision Making by Methamphetamine-Dependent Subjects Is Associated with Error-Rate-Independent

    Biology and Medicine Websites

    California at San Diego, University of

    . Brown, and Marc A. Schuckit Background: One important aspect in decision making is how success), which may imply that MD are more influenced by success. This study examined whether the degree of success and the degree of predictability differentially affected MD's deci- sion making. Methods: Using

  19. Modulators of maladaptive decision-making in methamphetamine dependence: A multimodal neuroimaging approach

    University of California eScholarship Repository

    Kohno, Milky

    2013-01-01

    Brain regions where the relationship between resting-state connectivity with the DLPFC seed (shown in blue) andblue) and putamen, amygdala, hippocampus, insula, and prefrontal cortex in MA-dependent compared to healthy individuals (p < 0.05, whole-brainblue) with caudate, putamen, nucleus accumbens, and orbital frontal cortex (p < 0.05, whole-brain

  20. Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells

    Biology and Medicine Websites

    Kenny, Paraic

    breast cancer cells Merril C. Curry a , Amelia A. Peters a , Paraic A. Kenny b , Sarah J. Roberts online xxxx Keywords: Mitochondrial calcium uniporter Breast cancer Calcium Ionomycin Cell death ABT-263 and the conse- quences of MCU silencing in a breast cancer cell line. Our results indicate that estrogen

  1. Rising prevalence of asthma is sex-specific in a US farming Caroline A. Motika, MD,a

    Computer Technologies and Information Sciences Websites

    Abney, Mark

    Rising prevalence of asthma is sex-specific in a US farming population Caroline A. Motika, MD, and Philadelphia, Pa Background: Asthma prevalence is increasing worldwide in most populations, likely due populations are protected from asthma, which has been attributed to their traditional lifestyles and farming

  2. Rear-Facing Car Safety Seats: Getting the Message Marilyn J. Bull, MDa, Dennis R. Durbin, MD, MSCEb

    Geosciences Websites

    manufacturers, and many research facilities, and the support of child passenger safety advocates across to 23 months old, the odds were 5.32 times higher. This information is additionally supported by data to the highest weight that is allowed for use by the manufacturer of the seat.4 Health care providers and many

  3. Associate editor: S. Pestka Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: Key regulators of

    Biology and Medicine Websites

    DeSalle, Rob

    minutes of infection to produce type I interferons and pro- inflammatory cytokines. Interferons induce T cells. Despite the discovery of interferons over 50 years ago, only recently have we begun to understand encoding interferons and other cytokines. A second family of pattern recognition receptors has recently

  4. ORIGINAL RESEARCH ARTICLE Candidate genes, pathways and mechanisms for bipolar

    Biology and Medicine Websites

    California at San Diego, University of

    pharmacogenomic mouse model (involving treatments with a stimulant--methamphetamine, and a mood stabilizer; microarray; convergent functional genomics; methamphetamine; valproate; pain Bipolar (manic and related disorders. Single-dose methamphetamine treatment in hu- mans and animals mimics many

  5. Please cite this article in press as: Wittmann, M. et al., Impaired time perception and motor timing in stimulant-dependent subjects, Drug Alcohol Dependence (2007), doi:10.1016/j.drugalcdep.2007.03.005

    Biology and Medicine Websites

    California at San Diego, University of

    2007-01-01

    . All rights reserved. Keywords: Methamphetamine; Cocaine; Dopamine; Temporal processing; Working memory of dopamine via reverse transport (Sulzer et al., 2005). Methamphetamine (METH), a compound structurally

  6. This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the

    Biology and Medicine Websites

    Matell, Matthew S.

    Available online 20 April 2007 Methamphetamine (MAP), an indirect dopamine agonist, has been shown rights reserved. Keywords: Time perception Methamphetamine Single trials 1. Introduction Interval timing

  7. Behavioral/Systems/Cognitive Different Forms of Self-Control Share a Neurocognitive

    Biology and Medicine Websites

    Aron, Adam

    resonance images from 44 healthy and 43 methamphetamine-dependent subjects. Individuals with methamphetamine, respectively); and methamphetamine-dependent subjects provided self-reports of their craving for methamphetamine. Performance levels on the two inhibitory control tasks were correlated with one another

  8. The Emerging Problem of Methamphetamine: A Threat Signaling the Need to Reform Criminal Jurisdiction in Indian Country

    University of Kansas - KU ScholarWorks

    Kronk, Elizabeth Ann

    2006-01-01

    Country is a result of the ineffective criminal jurisdictional scheme created by the Major Crimes Act, the Indian Civil Rights Act of 1968 and the Supreme Court’s decision in Oliphant v. Suquamish Indian Tribe . Therefore, the emerging problem of meth use...

  9. Affective Correlates of Stimulant Use and Adherence to Anti-retroviral Therapy Among HIV-positive Methamphetamine Users

    University of California eScholarship Repository

    Carrico, Adam W.; Johnson, Mallory O.; Colfax, Grant N.; Moskowitz, Judith Tedlie

    2010-01-01

    and depression to antiretroviral med- ication adherence in persons with HIV.and depression (Sundin and Horowitz 2002, 2003). In order to assess HIV-depression on adherence to HAART and CD4? counts in people living with HIV.

  10. Psychopharmacology (1991) 104:6-16 0033315891000714 Psychophannacology

    Biology and Medicine Websites

    California at San Diego, University of

    1991-01-01

    increased a while de- creasing d, whereas amphetamine, nicotine, and caffeine produced an increased on the microscopic elements of behavior. Key words: Psychostimulants - Amphetamine - Dopa- mine - Locomotor activity

  11. Profilin1 regulates PI(3,4)P-2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

    MIT - DSpace

    Bae, Yong Ho

    Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell migration through actin cytoskeletal regulation. Given the traditional view of profilin1 as a promigratory molecule, it is difficult ...

  12. Neuron, Vol. 19, 12711283, December, 1997, Copyright 1997 by Cell Press Vesicular Transport Regulates Monoamine Storage

    Biology and Medicine Websites

    Sulzer, David

    Regulates Monoamine Storage and Release but Is Not Essential for Amphetamine Action activities use the Na to the original hypothesis that monoamine transmit- brain cultures from the mutant animals, amphetamine ters have. In The action of amphetamines further indicates the po- vivo, amphetamine increases movement, promotes tential

  13. Curriculum Vitae Hyungjun Kim, Ph.D.

    Biology and Medicine Websites

    Napadow, Vitaly

    : Structural connectivity in Methamphetamine abusers using Diffusion tensor imaging, Amygdala shape alterations in Methamphetamine abusers (Advisor: In Kyoon Lyoo, M.D., Ph.D.) 2003 Korean Medical Doctor, College of Oriental

  14. Influence of PCPA and MDMA (ecstasy) on physiology, development and behavior in Drosophila melanogaster

    Biology and Medicine Websites

    Cooper, Robin L.

    , synapse Abstract The effects of para-chlorophenylalanine (PCPA) and 3,4 methylenedioxy-methamphetamine by the use of two pharmacological compounds [i.e. para-chlorophenylalanine (PCPA) and 3,4 methylenedioxy-methamphetamine

  15. NEUROPSYCHOPHARMACOLOGY 2002VOL. 26, NO. 1 2001 American College of Neuropsychopharmacology

    Biology and Medicine Websites

    California at San Diego, University of

    Dysfunction in Methamphetamine-Dependent Subjects Martin P. Paulus, M.D., Nikki E. Hozack, Blanca E. Zauscher in different prefrontal areas. This investigation tested the behavioral hypothesis that methamphetamine cortex. Ten methamphetamine-dependent subjects were compared with ten age- and education-matched controls

  16. ORIGINAL INVESTIGATION Single-trials analyses demonstrate that increases in clock

    Biology and Medicine Websites

    Matell, Matthew S.

    to the methamphetamine-induced horizontal shifts in peak-interval timing functions Matthew S. Matell & Melissa Bateson. Materials and methods The present report evaluates the effects of five doses of methamphetamine (MAP) (0 of the present experiment is to evaluate whether methamphetamine (MAP)-induced alterations in behavior

  17. Available online at www.sciencedirect.com Drug and Alcohol Dependence 94 (2008) 258262

    Biology and Medicine Websites

    Silver, Rae

    2008-01-01

    communication Residual effects of intranasal methamphetamine on sleep, mood, and performance Audrey Y. Pereza intranasal methamphetamine abuse has increased, there are no published data investigating the residual of single-dose intranasal methamphetamine administration on a broad range of behavioral and physiological

  18. Neurotoxicity Research, Vol. 1, pp. 181-195 Reprints available directly from the publisher

    Biology and Medicine Websites

    Sulzer, David

    neuromelanin and since cytosolic dopamine-dependent oxyradical formation may underlie methamphetamine toxicity's disease, Lewy bodies, Methamphetamine, Oxidative stress, VMAT, Substantia nigra, Tyrosinase Abbreviations; mRNA, messenger RNA; METH, methamphetamine; MPTP, 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine; NE

  19. Neurobiology of Disease Structural Abnormalities in the Brains of Human Subjects

    Biology and Medicine Websites

    Thompson, Paul

    Methamphetamine Paul M. Thompson,1 Kiralee M. Hayashi,1 Sara L. Simon,2 Jennifer A. Geaga,1 Michael S. Hong,1, the profile of structural deficits in the human brain associated with chronic methamphetamine (MA) abuse-based maps suggest that chronic methamphetamine abuse causes a selective pattern of cerebral deterioration

  20. Anterior Cingulate Cortex and Benefit of Predictive Cueing on Response Inhibition in

    Biology and Medicine Websites

    California at San Diego, University of

    : Methamphetamine dependence (MD) is associated with impaired response inhibition and with structural abnormalities with response inhibition. Key Words: Anterior cingulate cortex, drug dependence, fMRI, go/nogo, methamphetamine, a number of studies also have demon- strated ACC abnormalities in individuals with methamphetamine abuse

  1. Mining Higher-Order Association Rules from Distributed Named Entity Databases

    Computer Technologies and Information Sciences Websites

    Pottenger, William M.

    enforcement and homeland defense. For example, methamphetamine use is the number one drug problem in 60% of US Enforcement Administration (DEA) has conducted several operations to investigate the entire methamphetamine individuals in ten cities throughout the United States and Canada in an international methamphetamine

  2. Brief Communications Neural Encoding of Psychomotor Activation in the Nucleus

    Biology and Medicine Websites

    Cheer, Joseph F.

    in methamphetamine-induced psychomotor activa- tion. Rats were treated with bilateral, intracranial microinjections by intravenous methamphetamine (3 mg/kg). Antagonist pretreatment in the nucleus accumbenscore by methamphetamine (0.01, 0.1, 1, 3 mg/kg; cumulative dosing). We observed robust, phasic changes in neuronal firing

  3. Transient Overexpression of {alpha}-Ca2+/Calmodulin-Dependent Protein Kinase II in the Nucleus Accumbens Shell Enhances Behavioral Responding to Amphetamine

    MIT - DSpace

    Loweth, Jessica A.

    Ca[superscript 2+]/calmodulin-dependent protein kinase II (CaMKII) is known to contribute to the expression of psychostimulant sensitization by regulating dopamine (DA) overflow from DA neuron terminals in the nucleus ...

  4. Risky Subjectivity : : The Effects of Cultural Discourses of Addiction on Methamphetamine Using HIV+ Men Who Have Sex with Men in San Diego

    University of California eScholarship Repository

    Gideonse, Theodore Karwoski

    HIV and other STDs, but also with petty and violent crime, the public health and lawand law enforcement organizations reacted to and tried to reshape the subjectivities of HIVHIV and other STDs, and because of a moral panic inspired by these problems (see Chapter 1), public health and law

  5. Neuroscience and Biobehavioral Reviews 35 (2011) 18471853 Contents lists available at ScienceDirect

    Environmental Sciences and Ecology Websites

    Huber, Robert

    2011-01-01

    States a r t i c l e i n f o Keywords: Drug reward Amphetamine Cocaine Heroin Motivation Decapoda those envi- ronments that had previously been paired with the psychostimulants cocaine and amphetamine

  6. ARCHIVAL REPORT Nondependent Stimulant Users of Cocaine and

    Biology and Medicine Websites

    California at San Diego, University of

    ARCHIVAL REPORT Nondependent Stimulant Users of Cocaine and Prescription Amphetamines Show Verbal: Stimulants are used increasingly to enhance social (cocaine) or cognitive performance (stimulants normally and methylphenidate, intensifies these deficits. Key Words: Amphetamine, cocaine, executive function, stimulant

  7. Disruption of Mesolimbic Regulation of Prefrontal Cholinergic Transmission in an Animal Model of Schizophrenia and

    Biology and Medicine Websites

    Bruno, John P.

    . Amphetamine-evoked ACh release was assessed in nVHLX animals to exclude potential limitations in release capacity. Amphetamine produced greater increases in ACh release than in shams, indicating that nVHLX does

  8. 118 Current Medical Imaging Reviews, 2011, 7, 118-124 1573-4056/11 $58.00+.00 2011 Bentham Science Publishers Ltd.

    Biology and Medicine Websites

    Morris, Evan D,

    - nipulation of the dopamine system (e.g., amphetamine, cocaine, methylphenidate). More recently, there has provokes an increase in endogenous NT (e.g., a surge in dopamine after amphetamine administration

  9. NEUROSYSTEMS Astrocyte-derived kynurenic acid modulates basal and

    Biology and Medicine Websites

    Bruno, John P.

    Keywords: amphetamine, glia, microdialysis, prefrontal cortex, schizophrenia Abstract We tested release caused by d-amphetamine (2.0 mg / kg). This effect was duplicated by the systemic administration

  10. Presynaptic Regulation of Dopamine Transmission in Schizophrenia Gholson J. Lyon2,8

    Biology and Medicine Websites

    Sulzer, David

    of widespread psychosis in populations in which amphetamines were widely abused, such as post­World War II Japan and Sweden in the 1940s and 1950s.16,17 Amphetamines release massive amounts of DA from presynaptic terminals

  11. MARCH 2002 NOTICES OF THE AMS 333 Conversationsabout

    Mathematics Websites

    Russo, Bernard

    at conferences taking amphetamines to keep themselves in high gear. Auburn--who has a great deadpan sense play--offered Erdos as an example of a math- ematician thought to have used amphetamines, but agreed

  12. Prepulse Inhibition Deficits and Perseverative Motor Patterns in Dopamine Transporter Knock-Out Mice: Differential Effects of D1

    Biology and Medicine Websites

    California at San Diego, University of

    , 1980). Disruptions in PPI are produced in rodents using dopamine (DA) agonists such as amphetamine that the D2 receptor is necessary for amphetamine to exert its disruptive effects on PPI (Ralph et al., 1999

  13. Psychopharmacology (1993) 113:187-198 Psychopharmacology

    Biology and Medicine Websites

    California at San Diego, University of

    1993-01-01

    . The effects of four indirect dopamine agonists, d- amphetamine (0.25 4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR of these drugs. Specifically, rats treated with d-amphetamine (cocaine ( in behavioral organiza- tion. In particular, 4.0mg/kg d-amphetamine and 40.0 mg/kg cocaine increased

  14. Behavioural Brain Research 153 (2004) 171180 Research report

    Environmental Sciences and Ecology Websites

    Huber, Robert

    2004-01-01

    . The first set of experiments demonstrated that intramuscular injections of cocaine and amphetamine have. Amphetamine and, to a lesser extent, cocaine were both found to serve as rewards when their intra; Addiction; Amphetamine; Cocaine; Decapoda; Crustacea; Arthropoda 1. Introduction Invertebrate model systems

  15. Brain Research 894 (2001) 354358 www.elsevier.com/locate/bres

    Biology and Medicine Websites

    Bruno, John P.

    2001-01-01

    between the effects of intra-accumbens administration of amphetamine and exposure to a novel environment Previous research has demonstrated an interaction between the effects of amphetamine and exposure, the administration of intra-accumbens amphetamine was hypothesized to potentiate the increase in cortical

  16. Small Effect of Dopamine Release and No Effect of Dopamine Depletion

    Biology and Medicine Websites

    Pike, Victor W.

    D2 radioligand; D-amphetamine; a-methyl-para-tyrosine; phasic; tonic; PET ABSTRACT Molecular imaging]fallypride and (2) both D-amphetamine-induced and a-methyl-p-tyrosine (AMPT)-induced changes in dopamin release studies at baseline and fol- lowing oral D-amphetamine administration (0.5 mg/kg) and oral AMPT

  17. ORIGINAL INVESTIGATION GBR 12909 administration as a mouse model of bipolar

    Biology and Medicine Websites

    California at San Diego, University of

    treated with the catecholamine transporter inhibitor amphetamine or the selective DAT inhibitor GBR 12909 and its potential strain dependency by testing 129/SvJ mice. Results Amphetamine produced hyperactivity disorder. Mania . Mouse model . Dopamine transporter. Amphetamine . GBR 12909 Introduction Bipolar disorder

  18. SRF Essay Contest 1 | P a g e The Schizophrenia Research Forum

    Biology and Medicine Websites

    Fact 1: Exposure to amphetamine can result in schizophrenia-like symptoms in some individuals. This effect is observed in chronic, but not acute, amphetamine use (Segal et al., 1997). Fact 2, and amphetamine exposure has opposite effects in two subregions of prefrontal cortex--a progressive

  19. Am J Psychiatry 163:9, September 2006 1639ajp.psychiatryonline.org Brief Report

    Biology and Medicine Websites

    Park, Sohee

    in Amphetamine-Induced Displacement of [18F]Fallypride in Striatal and Extrastriatal Regions: A PET Study- sion tomography (PET) with [18F]fallypride before and after an oral dose of d-amphetamine. Percent increases striatal dopamine synthesis, baseline dopamine release, d-amphetamine-induced dopamine release

  20. Preprint Collection of Charles J. Wilson Self-inhibition By Dopaminergic Neurones: Disruption By (+/-)-alpha-methyl-

    Biology and Medicine Websites

    Wilson, Charles J.

    (+)-Amphetamine sulphate infused directly into the substantia nigra, pars compacta, at low rates and in low to block amphetamine-induced release of dopamine from dopaminergic terminals in the neostriatum (Spector intravenous amphetamine administration (Bunney et al., 1973). Further, diencephalic transections ante- rior

  1. Brain Research 894 (2001) 7487 www.elsevier.com/locate/bres

    Biology and Medicine Websites

    Bruno, John P.

    2001-01-01

    Brain Research 894 (2001) 74­87 www.elsevier.com/locate/bres Research report Amphetamine administration of amphetamine results in increases in the release of acetylcholine in the cortex. Basal forebrain for amphetamine-induced increase in cortical acetylcholine by examining whether intra-basalis perfusion

  2. Sparing of behavior and basal extracellular dopamine after 6-hydroxydopamine lesions of the nigrostriatal pathway

    Biology and Medicine Websites

    Schallert, Tim

    of the nigrostriatal pathway in rats exposed to a prelesion sensitizing regimen of amphetamine Isabella Anna Moroz,a,1 of amphetamine leads to enduring augmentation of its behavioral-activating effects, enhanced dopamine (DA to a 2-week escalating-dose regimen of amphetamine prevents behavioral asymmetries of forelimb use

  3. Sexual Compulsivity Among Men in a Decentralized MSM Community of the Midwestern United States

    University of Kansas - KU ScholarWorks

    Satinsky, Sonya; Fisher, Christopher; Stupiansky, Nathan; Dodge, Brian; Alexander, Andreia; Herbenick, Debby; Reece, Michael

    2008-01-01

    ), marijuana (pot), and crystal methamphetamine. Participants were asked to indicate whether or not they had used the drug in the past 90 days. Participants were also asked whether they had ever been told by a health care provider that they had a drug... consumption based on sexual compulsivity scores. Reported use of crystal methamphetamine use was not statistically different be- tween groups, which may be reflective of very low incidence of reported methamphetamine use (0.06%, n ? 31) in this sample...

  4. 2001 ,7 (4) :348 354 Chin J Appl Environ Biol = ISSN 1006 -687X 2001208225

    Environmental Sciences and Ecology Websites

    ,--¨¶"´¶~ SOD¡¢ POD " CAT »--... MDA "SOD " POD »-- ^,·,--¨OE . ´°l,--¨´ ,¸¯--¨¿¶¨"--¨°­...~... ,,--¨OE¶~ SOD »--^,·,--¨ OE ,MDA " ¡¡ The effects of endophyte infection on the activities of SOD , POD and CAT , as well as on MDA contents in L

  5. From HEALTH TOPICS on the UHS Web site www.rochester.edu/uhs

    Biology and Medicine Websites

    Cantlon, Jessica F.

    to methamphetamine (see meth) and can lead to death after a very short period of use. PHYSICAL EFFECTS X primarily/or methamphetamine. All of the aforementioned substances increase the risk X poses to the user, and can lead to a new

  6. Facilitation of efficient search of an unbaited radial-arm maze in rats by D1, but not D2, dopamine receptors

    Biology and Medicine Websites

    Timberlake, William D.

    , increased the number of novel arms chosen in the first eight arms entered. Treatment with 0.1 mg/kg sc D-amphetamine following a test day with a 1.0 mg/kg dose. The 0.1-mg/kg amphetamine-induced facilitation was blocked preparatory behavior. D 2001 Elsevier Science Inc. All rights reserved. Keywords: SKF81297; Amphetamine; SCH

  7. THE FIVE FACTOR MODEL OF PERSONALITY AND

    Computer Technologies and Information Sciences Websites

    Gorban, Alexander N.

    Benzodiazepines Legal highs Cannabis LSD Chocolate Methadone Cocaine Magic mushrooms Caffeine Nicotine Crack VSA mushrooms 0 0 + - - Amphetamines, Benzodiazepines, Cannabis, Cocaine, Ecstasy, Ketamine, and Legal highs + 0

  8. Division of Human Resources Alcohol & Drug Testing (CDL)

    Geosciences Websites

    Meyers, Steven D.

    prohibited from use and for which tests are administered (i.e., cannabinoids [marijuana], cocaine, opiates], cocaine, opiates, phencyclidine [PCP], and amphetamines). Reasonable Suspicion - A determination made

  9. ZHAO ET AL. VOL. 6 ' NO. 10 ' 86848691 ' 2012 www.acsnano.org

    Biology and Medicine Websites

    Högberg, Björn

    breast cancer cell lines: MDA-MB-231, MDA-MB-468, and MCF-7. Received for review May 22, 2012 cells. We have tested two DNA origami nanostructures on three different breast cancer cell lines (MDA-MB-231, MDA-MB-468, and MCF-7). The different nanostructures were designed to exhibit varying degrees

  10. Minimal Non-Deterministic xor Automata Jean Vuillemin, Nicolas Gamma

    Computer Technologies and Information Sciences Websites

    Vuillemin, Jean

    -deterministic transitions. Each automaton X and M = mda L is a strong normal form SNF: L = L mxa L = mxa L mda L = mda L A exp lin lin With such SNF [2], one maps different states of the MDA to different com- puter memory

  11. Affective Analgesia Following Muscarinic Activation of the Ventral Tegmental Area in Rats

    Biology and Medicine Websites

    Borszcz, George S.

    from observations that strong an- algesics (eg, morphine, amphetamine) have high abuse potential to nucleus accumbens (nAb) underlies the reinforcement produced by morphine, amphet- amine, other drugs of morphine and amphetamine.2 Mesoaccumbal dopaminergic neurons in the VTA are activated via cholinergic

  12. Evidence for subtle verbal fluency deficits in occasional stimulant users: Quick to play loose with verbal rules

    Biology and Medicine Websites

    California at San Diego, University of

    Accepted 7 July 2010 Keywords: Stimulant Cocaine Amphetamine Executive function Verbal fluency a b s t r a c t Psychostimulants like cocaine and amphetamine are commonly abused by young adults who often rights reserved. 1. Introduction Since prices for recreational stimulants like powder cocaine are falling

  13. Disruption of EphA/ephrin-A signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral

    Biology and Medicine Websites

    Ibáñez, Carlos

    and dissociates behavioral responses to amphetamine and cocaine Beth-Anne Sieber,a,1 Alexander Kuzmin,b Josep M transmission revealed an unexpected dissociation of the behavioral responses to amphetamine and cocaine- siveness to cocaine, which, to the best of our knowledge, represents the first report of a dissociation

  14. Illicit drug use and anxiety disorders: Findings from two community surveys

    Biology and Medicine Websites

    California at San Diego, University of

    disorders and lifetime use of amphetamines, cocaine, hallucinogens and heroin in two contemporaneous samples of amphetamines, hallucinogens, cocaine, and heroin. Posttraumatic stress disorder was assessed only in the US diagnosis and lifetime stimulant use, cocaine use, and hallucinogen use was found in both surveys (OR 1

  15. Single-Quantum-Dot Tracking Reveals Altered Membrane Dynamics of an Attention-Deficit/Hyperactivity-Disorder-Derived Dopamine

    Engineering Websites

    , Tennessee 37831, United States *S Supporting Information ABSTRACT: The presynaptic, cocaine- and amphetamine disorders. KEYWORDS: Attention deficit/hyperactivity disorder, amphetamine, cocaine, dopamine transporter-deficit/hyperactivity disor- der.3-10 In addition, DAT is a major target for the widely abused psychostimulants, cocaine

  16. Fwg. hkumPsychy?klmmcoi d Bti Pswt. IQsl. Vol. 15,pp. 003-919 PzintedtnGreatBritain. AUrt&ta maewat

    Biology and Medicine Websites

    California at San Diego, University of

    with amphetamine or cocaine on the amouirt, the structure, and the unpredictabilityof micro-events of ratAcg) treated animals and increased a significantly reduced d for cocaine (20.0 mg/kg) treated animals, without independently of the typically measured amount of motor activity, Keywords: amphetamine, cocaine, dynamical

  17. ORIGINAL INVESTIGATION Memory and psychostimulants: modulation of Pavlovian

    Biology and Medicine Websites

    Anagnostaras, Stephan

    and attention deficit hyperactivity disorder (ADHD). Amphetamine (e.g., Adderall®) improves ADHD symptoms containing amphetamine have proven beneficial to many people suffering from ADHD, excessive daytime of evidence demonstrates that healthy volunteers, not just those with ADHD, display cognitive benefits from

  18. Development of human brain connectivity in health and disease

    University of California eScholarship Repository

    Colby, John Benjamin

    2012-01-01

    IEEE transactions on medical imaging 29(4), 1039– 49. [demographics and medical history, brain imaging (including aimaging, teratogen, in utero 2.2 Introduction Methamphetamine (MA) abuse is a signi?cant medical and

  19. ORIGINAL ARTICLE Disorders of compulsivity: a common bias towards

    Biology and Medicine Websites

    Dayan, Peter

    natural (binge eating) and artificial (methamphetamine) rewards, and obsessive-compulsive disorderOPEN ORIGINAL ARTICLE Disorders of compulsivity: a common bias towards learning habits V Voon1 neurocomputational mechanism may underlie diverse disorders involving compulsion. Molecular Psychiatry advance online

  20. Bi23 Tutorials, Winter Term 2016, All 3 units 1. Visual Neuroscience: From Photon to Perception

    Engineering Websites

    Faraon, Andrei

    , but also as demons, for the damage wrought by drugs such as cocaine, heroin, and crystal methamphetamine, such as antidepressants, cocaine, heroin, and emerging therapeutics like ketamine. The first two classes will introduce

  1. Gender-specific modulation of cocaine-induced place preference by 3,4-methylenedioxymethamphetamine 

    Texas A&M University - TxSpace

    Diller, Anna Jean

    2013-02-22

    In contemporary North-American culture, two frequently combined drugs possessing abuse liability are cocaine and "ecstasy" (+/- 3,4-methylenedioxy-methamphetamine [MDMA]). Each drug is a stimulant acting on brain dopamine sites, i.e., cocaine acts...

  2. Illicit substance use and risk of HIV transmission among men who have sex with men

    University of California eScholarship Repository

    Drumright, Lydia Nicole

    2006-01-01

    sexually transmitted diseases, and risk behaviors among methamphetamine-dependent gay and bisexual men seeking outpatient drug abuse treatment.treatment on HIV shedding in genital-tract secretions - Systematic review and data synthesis. Sexually Transmitted Diseases.

  3. Risk taking in disorders of natural and drug rewards: neural correlates and effects of probability, valence and magnitude

    University of Cambridge - Dspace

    Voon, Valerie; Morris, Laurel S.; Irvine, Michael A.; Ruck, Christian; Worbe, Yulia; Derbyshire, Katherine; Rankov, Vladan; Schreiber, Liana R. N.; Odlaug, Brian L.; Harrison, Neil A.; Wood, Jonathan; Robbins, Trevor W.; Bullmore, Edward T.; Grant, Jon E.

    2014-10-15

    weighting in healthy volunteers. In the anticipation of rewards, subjects with binge eating disorder show greater risk taking, similar to substance use disorders. Methamphetamine dependent subjects had greater non-linearity of probability weighting along...

  4. Experimentally Examining the Effects of a Neighborhood Intervention to Reduce Theft in Multiple City Neighborhoods

    University of Kansas - KU ScholarWorks

    Evensen, Paul E.

    2010-04-21

    , local leaders, professionals or Safe Streets staff members. Topics for additional training included Crime Prevention Through Environmental Design (CPTED), drug paraphernalia, methamphetamine labs, zoning issues, community history, and the like. A... to important data about community concerns and for tracking progress on thefts. Further, community law enforcement officers can inform residents of new crime-related issues, such as the risk methamphetamine laboratories pose to neighborhood health...

  5. Cross-Correlations of Linearly and Quadratically Related Geometric Sequences and GMW Sequences

    Mathematics Websites

    Klapper, Andy

    by the National Security Agency under Grant Number MDA904-91-H-0012. The United States Government is authorized, Boston, MA 02115. Project sponsored by the National Security Agency un- der Grant Number MDA904-91-H-0012

  6. Cross-Correlations of Linearly and Quadratically Related Geometric Sequences and GMW Sequences

    Mathematics Websites

    Klapper, Andy

    sponsored by the National Security Agency under Grant Number MDA904-91-H-0012. The United States Government University, Boston, MA 02115. Project sponsored by the National Security Agency un- der Grant Number MDA904

  7. Determining 2-integrin and ICAM-1 binding kinetics in tumor cells adhesion to leukocytes and endothelial cells by a gas-driven micropipette assay*

    Engineering Websites

    Dong, Cheng

    under blood flow. In contrast, the adhesions between human MDA-MB-231 metastatic breast carcinoma cells on MDA-MB-231 cells and HPMECs are similar. Furthermore, differences were observed in the intrinsic

  8. A microfluidic model for organ-specific extravasation of circulating tumor cells R. Riahi, Y. L. Yang, H. Kim, L. Jiang, P. K. Wong, and Y. Zohar

    Biology and Medicine Websites

    Wong, Pak Kin

    to demonstrate extravasation of MDA-MB-231 cancer cells in the presence of CXCL12 chemokine gradients. Consistent that the MDA-MB-231 cell migration is attributed to chemotaxis rather than a random process. VC 2014 AIP

  9. 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim5512 wileyonlinelibrary.com COMMUNICATION

    Biology and Medicine Websites

    Kilian, Kristopher A.

    in the surrounding peptide-modified alginate. We choose to use a human breast adenocarcinoma (MDA-MB-231) cell type fibers in a single step is illustrated in Figure 1. First, human breast adenocarcinoma (MDA-MB-231

  10. DIRECTORIO DE EXTENSIONES TELEFONICAS NUMERO CONMUTADOR: 942-94-00

    Mathematics Websites

    . Director 9401 (999)9429401 decoss@mda.cinvestav.mx A MARTINEZ AGUILAR, Maria Antonieta Asistente del leonorc@mda.cinvestav.mx H Fax Directo 981-46-70 VORRATH DOMINGUEZ, Celeste Apoyo Secretarial 2330. Investigador 9408 (999)9249408 agarcia@mda.cinvestav.mx H DOMINGUEZ AGUILAR, Mauricio, Dr. 2215 mauricio

  11. Distinct Regulation of Cytoplasmic Calcium Signals and Cell Death Pathways by Different Plasma Membrane Calcium

    Biology and Medicine Websites

    Kenny, Paraic

    Membrane Calcium ATPase Isoforms in MDA-MB-231 Breast Cancer Cells* Received for publication,March 20, 2012-dependent and -independent cell death in MDA-MB-231 cells. Conclusion: PMCA isoforms have distinct roles in the control viability in MDA-MB-231 breast cancer cells. The PMCA1 isoform was the predominant regulator of global Ca2

  12. Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members

    Computer Technologies and Information Sciences Websites

    Yanikoglu, Berrin

    by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells Elif Damla Arisan Æ Ozgur Kutuk Æ Tugsan-dependent manner in MCF-7 (drug-sensitive) and MDA-MB-231 (drug-insensitive) cells. Furthermore, when we of paclitaxel was much less potent only in MDA-MB-231 cells. To further understand the distinct role of drugs

  13. Golgi Calcium Pump Secretory Pathway Calcium ATPase 1 (SPCA1) Is a Key Regulator of Insulin-like Growth Factor

    Biology and Medicine Websites

    Kenny, Paraic

    -like Growth Factor Receptor (IGF1R) Processing in the Basal-like Breast Cancer Cell Line MDA-MB-231* Received to the Golgi. Inhibition of SPCA1 in MDA-MB-231 cells produced pronounced changes in cell proliferation induction or changes in global cal- cium signaling. Instead, the effects of SPCA1 inhibition in MDA-MB-231

  14. Bulletin of Mathematical Biology A Journal Devoted to Research at the

    Mathematics Websites

    Balasuriya, Sanjeeva

    the formation of a monolayer of cells using two different cell types: 3T3 fibroblast cells and MDA MB 231 breast that the 3T3 fibroblast monolayer forms without clustering. Alternatively, the MDA MB 231 cells are less motile and we observe that the MDA MB 231 mono- layer formation is associated with significant clustering

  15. University of Southampton Research Repository ePrints Soton

    Computer Technologies and Information Sciences Websites

    the highly invasive MDA-MB-231 cell line compared to oestrogen receptor positive MCF7 cells (IC50 7.18 ± 1 the growth inhibitory effects of PEITC, especially in MDA-MB-231 cells, suggesting that ROS are important for the growth inhibition. Consistent with this, PEITC-induced ROS accumulation was detected in MDA-MB-231 cells

  16. ECBS2004--Brno Improving CBS Tool Development

    Computer Technologies and Information Sciences Websites

    Sprinkle, Jonathan

    ... · Middleware Platforms ­ CORBA, EJB · XML ­ XML DTDs, XSL, XMI · Modeling ­ MDA, MIC Unix Windows Mac Documentware XLINK XPath etc. MM ModelwareMDA MIC etc. Declarative Object Oriented Unix Windows MacOs Operating XLINK XPath etc. MM ModelwareMDA MIC etc. Declarative Object Oriented #12;Jonathan Sprinkle, UC Berkeley

  17. Author's personal copy Journal of Biotechnology 149 (2010) 215225

    Computer Technologies and Information Sciences Websites

    Feng, Jianfeng

    2010-01-01

    that release growth-hormone releasing peptide; two populations of appetite regulating neurons, one of which makes both melanocyte stimulating hormone ( -MSH) and cocaine- and amphetamine-related transcript

  18. Physiology & Behavior, Vol. 66, No. 4, pp. 639643, 1999 1999 Elsevier Science Inc.

    Biology and Medicine Websites

    Knutson, Brian

    ) and morphine (MORPH)]. In Experiment 1, rats made a greater percentage of 50-kHz USVs on the AMPH-paired side of pharmacological reward. © 1999 Elsevier Science Inc. Reward Vocalization Rat Amphetamine Morphine CAREFUL

  19. Behavioral/Systems/Cognitive Cannabinoids Enhance Subsecond Dopamine Release in the

    Biology and Medicine Websites

    Cheer, Joseph F.

    -related behaviors such as cocaine self-administration (Phillips et al., 2003) and operant responding for natural, 1988; Nestler, 2002; Wise, 2002). Some abused drugs such as amphetamine and cocaine have direct actions

  20. Classifying the World Anti-Doping Agency’s 2005 Prohibited List Using the Chemistry Development Kit Fingerprint

    University of Cambridge - Dspace

    Cannon, Edward O.; Mitchell, John B. O.

    2006-01-01

    system. Ex- amples of stimulants include cocaine, amphetamine and modafinil; caffeine has re- cently been removed from the WADA prohibited list. These substances make the user feel more alert, energetic and able to concentrate. Narcotics (S7) enhance...

  1. Flexibility in Design, Outcomes and Analysis in “Evidence- Based” Drug Prevention Research: The Case of the Midwestern Prevention Project 

    Texas A&M University - TxSpace

    Gorman, Dennis M.

    2013-11-22

    analyses were presented. A number of other “hard” drugs were assessed in the MPP evaluation, including cocaine, barbiturates and heroin [10]; so why do Riggs et al. [29] only focus on amphetamines? Use of alcohol could mediate the effects...

  2. Neuronal cicuits and reinforcement mechanisms underlying feeding behaviour

    University of Cambridge - Dspace

    Huang Cao, Zhen Fang

    2015-03-03

    of the amygdala BMI: body mass index BNST: bed nucleus of stria terminalis BSA: bovine serum albumin CART: cocaine- and amphetamine-regulated transcript CCK: cholecystokinin List of Abbreviations xix CEA: central nucleus of the amygdala CEAlc: lateral...

  3. Addiction and action: Aristotle and Aquinas in dialogue with addiction studies 

    Texas A&M University - TxSpace

    Dunnington, Kent J.

    2009-05-15

    : From Biology to Drug Policy, 2d. ed. (Oxford: Oxford University Pres, 2001). A 4 nicotine, alcohol, opiates, cocaine and amphetamines, cannabis, and caffeine are considered particularly addictive because they either mimic or block the brain?s...

  4. DRUGS OF ABUSE IN URBANDRUGS OF ABUSE IN URBAN GROUNDWATER. A CASE STUDY

    Geosciences Websites

    Politècnica de Catalunya, Universitat

    the collective cocaine usage measuring benzoylecgonine levels in sewage and river water. 45% of a CO dose and metabolites belonging to 5 different chemical classes:g g Cocainics Amphetamine-like compoundsp p Opioids

  5. Sex Differences in the Relationship of Regional Dopamine Release to Affect and

    Biology and Medicine Websites

    Park, Sohee

    and extrastriatal regions were calculated using regions of interest (ROI) analysis and on a pixel-by-pixel basis at baseline and after administration of amphetamine. Correlations of changes in cognition and affect

  6. Statistical analysis of GABAA receptor modulators' effects in rats with focus on memory improvement and reversing of

    Mathematics Websites

    be effective in a putative animal model of schizophrenia; and, finally (iii) to develop a statistical model or amphetamine induced deficits which arguably reflect sensorimotor gating deficits seen in schizophrenia. Whilst......................................................................................................................................2 2.1. Schizophrenia and cognition

  7. Huddling and Independent Feeding of Neonatal Rats Can be

    Biology and Medicine Websites

    Sullivan, Regina M.

    to a novel odor (orange or cedar) while they received tactile stimulation (stroking of the body) or were pharmacological agent (e.g., amphetamine; Pedersen et al., 1982), and certain natural odors (e.g., maternal saliva

  8. Deutsche Akkreditierungsstelle GmbH Anlage zur Akkreditierungsurkunde D-PL-13168-02-00

    Biology and Medicine Websites

    Manstein, Dietmar J.

    , Headspace-GC) Flüssigchromatographie (HPLC-DAD, LC-Tandem-MS) Atomabsorptionsspektroskopie (AAS) Polymerase Medikamente, Drogen und Gifte Urin, Serum, Blut, Mageninhalt, Organe HPLC-DAD Amphetamin Serum, Blut, Urin

  9. Neurochemical Measurements in Rodents that Model Huntingtion's Disease and Oxidative Stress

    University of Kansas - KU ScholarWorks

    Ortiz, Andrea Naomi

    2011-05-31

    exhibit a blunted locomotor response to amphetamine, but not apomorphine, indicating that presynaptic dysfunction of the dopaminergic system is responsible for these behavioral alterations (Pineda et al., 2005). Nevertheless, it is not known if DA...

  10. Research Article Drug Testing

    Biology and Medicine Websites

    Gent, Universiteit

    the removal of pseudoephedrine from the list its use increased significantly. Of the individual sports indicator to control pseudopehedrine intake. To control the (ab)use of ephedrines in sports. Keywords: doping; urine; pseudoephedrine; cathine; sports; ephedrine; amphetamine Introduction Stimulants

  11. Abstract Rationale: Previous studies on the attentional effects of repeated psychostimulant administration in rats

    Biology and Medicine Websites

    Bruno, John P.

    may mediate the overprocessing of addictive drug-related stimuli, thus contributing to repeated com- pulsive addictive drug use. Key words Cortex · Acetylcholine · Nucleus accumbens · Dopamine · Amphetamine · Microdialysis · Addiction Introduction Repeated administration of psychostimulants produces potentiated

  12. Simultaneous Recruitment of Drug Users and Men Who Have Sex with Men in the United States and Russia Using Respondent-Driven Sampling: Sampling Methods and Implications

    University of California eScholarship Repository

    2009-01-01

    USA. In Russia, where methamphetamine-related drugs are theDrug Users and Men Who Have Sex with Men in the United States and Russiaand Russia. Of particular concern is HIV transmission from traditional higher risk groups, such as drug

  13. CURRICULUM VITAE David J. Eitle, Ph.D.

    Environmental Sciences and Ecology Websites

    Maxwell, Bruce D.

    of Adolescent Health" NIDA Grant No. R01DA034466-01 (07/15/2012-05/31/2015). ($657,195) 2010-2013 Joint, and Tamela McNulty Eitle. "Methamphetamine use among rural white and Native American adolescents: An Extension of Power-Control Theory to American Indian adolescents. Forthcoming at Deviant Behavior. 5

  14. Synthetic Methods DOI: 10.1002/anie.201200370

    Chemistry Websites

    be transformed into methamphetamine and other illegal drug substances, many countries restrict or ban its sale and distribution, thus complicating its use in industrial and academic settings.[2] Herein we report that (1S,2S are free from regulatory restrictions and are not known to be transformable into illicit substances, 2

  15. Are Supply-Side Drug Control Efforts Effective? Evaluating OTC Regulations Targeting

    Mathematics Websites

    Alexandrova, Ivana

    Are Supply-Side Drug Control Efforts Effective? Evaluating OTC Regulations Targeting Methamphetamine Precursors Carlos Dobkin, Nancy Nicosia, and Matthew Weinberg August 23, 2013 Keywords: Anti-Drug to reducing illegal drug use in the U.S., but evidence on their effectiveness is mixed. We provide new

  16. University of Wisconsin-Madison Policy on Mandatory Reporting of Child Abuse and Neglect

    Multidisciplinary Databases and Resources Websites

    Sheridan, Jennifer

    of Wisconsin System employees report incidents of child abuse and neglect. In addition, this policy extends for purposes of sexual arousal or sexual gratification. 7. Manufacturing methamphetamine with a child present that the manufacture would be seen, smelled, or heard by a child. 8. Emotional damage for which the child's parent

  17. Kathryn Dudley AMST S435/ANTH S243

    Biology and Medicine Websites

    Post, David M.

    (2000) William Garriott, Policing Methamphetamine: Narcopolitics in Rural America (2011) Jacob Hacker, June 2: Anthropology of Inequality · Hacker and Pierson, Winner-Take-All-Politics, pp. 11-40 Thurs and Dispossession Thurs, June 11: Neoliberalism · Hacker and Pierson, Winner-Take-All-Politics, pp. 41-160 Tues

  18. Computer Science at Kent Second European Workshop on Model

    Computer Technologies and Information Sciences Websites

    Kent, University of

    , Luís Ferreira Pires and Marten van Sinderen A M3-Neutral Infrastructure for System Engineering...........................................................................................................124 Why IT veterans are sceptical about MDA..............................................

  19. Oral activated charcoal adsorbent (AST-120) ameliorates CKD-induced intestinal epithelial barrier disruption

    University of California eScholarship Repository

    Vaziri, Nosratola D.; Yuan, Jun; Khazaeli, Mahyar; Masuda, Yuichi; Ichii, Hirohito; Liu, Shuman

    2013-01-01

    and creatinine concentrations, impaired urine concentratingurine protein excretion, and plasma creatinine, and ureacreatinine concentration (Cr), serum urea concentration, hematocrit (Hct), plasma malondialdehyde (MDA) concentration, and urine (

  20. Supporting Information Iliopoulos et al. 10.1073/pnas.1018898108

    Biology and Medicine Websites

    Tumors 103 4/4 4/4 NSCCs (MCF7) 4/4 0/4 Tumors 100 4/4 0/4 Tumors 105 4/4 2/4 CSCs (MDA-MB-231) 4/4 4/4 4/44/4 NSCCs (MDA-MB-231) 4/4 0/4 0/43/4 0 20 40 60 80 100 NSCCs CSCs NSCCs CSCs %CellViability Paclitaxel Doxorubicin 5FU MCF7 MDA-MB-231 Fig. S2. Properties of CSCs derived from MCF7 and MDA-MB-231 cells. (A) Tumor

  1. DEPARTAMENTO DE ECOLOGA HUMANA

    Mathematics Websites

    del Comportamiento, 1994) Universidad de Boston, EUA. Temas de investigación: Salud, nutrición y tradicional. Estado nutricional. Geografía de la salud. gbalam@mda.cinvestav.mx Eduardo Batllori Sampedro

  2. Immune Dermatomyopathies: Comparative Features IM + Perimysial

    Biology and Medicine Websites

    Baloh, Bob

    + Vascular pathology Regional Ischemic Immune Myopathy MDA5 antibody CLINICAL Age range Adult > Child Child Myositis-associated antibody Jo-1 tRNA synthetase Mi-2 p140; p155 No MDA5 (CADM140) CK > 1,000 Some Few

  3. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression

    University of California eScholarship Repository

    2008-01-01

    TP53, VHL; additional genes tested in BT-549, Hs578T, MCF-7,gene encoding PI3-Kinase have somewhat lower, but still substantial levels of p-Akt (BT-BT-474, HCC1569, SK-BR-3, MDA-MB-361, MDA- MB-453, UACC-812 have been reported to have amplified this gene (

  4. Asymptotic Analysis of Multivariate Coherent Risks lih@math.wsu.edu

    Mathematics Websites

    Li, Haijun

    Asymptotic Analysis of Multivariate Coherent Risks Haijun Li lih@math.wsu.edu Washington State University (Joint work with Harry Joe, University of British Columbia) 7th MDA, 08/10/2010 Haijun Li Asymptotic Analysis of Multivariate Coherent Risks 7th MDA, 08/10/2010 1 / 22 #12;Outline 1 Coherent Risks

  5. CTIT Technical Report TR-CTIT-04-12, University of Twente ISSN 1381 -3625

    Computer Technologies and Information Sciences Websites

    van Sinderen, Marten

    -Driven Architecture with Emphasis on Industrial Applications 1st European Workshop, MDA-IA 2004 Enschede developing the concepts of MDA in order to apply them to industrial sectors such as Air Traffic Management the technology and validating it on an industrial application in the air traffic management domain. The MODA

  6. The Role of miR-206 in the Epidermal Growth Factor (EGF) Induced Repression of Estrogen Receptor-

    Biology and Medicine Websites

    Terasaki, Mark

    , EGF treatments en- hanced miR-206 levels in MCF-7 cells and ER -negative, EGFR-positive MDA-MB-231 inhibitor, significantly reduced miR-206 levels in MDA-MB-231 cells. Blocking EGF-induced enhancement of mi

  7. IBMS BoneKEy | The 4th Joint Meeting of ECTS and IBMS 1 Citation: IBMS BoneKEy 13, Article number: 679 (2015) | doi:10.1038/bonekey.2015.46

    Biology and Medicine Websites

    Cai, Long

    2015-01-01

    .v. with 1x105 MDA-MB-231-IV breast cancer cells labelled with a lipophilic dye (Vybrant-DiD/ Vybrant occupying the niche by inject- ing 1x105 DiD labelled MDA-MB-231-IV cells and repeating the injection seven

  8. The International Journal of Biochemistry & Cell Biology 39 (2007) 93108 Regulation of acetylcholinesterase expression by calcium

    Biology and Medicine Websites

    Tian, Weidong

    2007-01-01

    by the mobilization of intracellular Ca2+ . During apoptosis, treatment of HeLa and MDA-MB-435s cells with the calcium in HeLa and MDA-MB-435s cells, effects that were also inhibited by BAPTA-AM. We further demonstratedThe International Journal of Biochemistry & Cell Biology 39 (2007) 93­108 Regulation

  9. Semantic Anchoring with Model Transformations

    Mathematics Websites

    Borgs, Christian

    .edu Abstract. Model-Integrated Computing (MIC) is an approach to Model-Driven Architecture (MDA), which has been developed primar- ily for embedded systems. MIC places strong emphasis on the use of domain the meta-programmable MIC tool suite. 1 Introduction The Model-Driven Architecture (MDA) advocates a model

  10. WAVELET DOMAIN ASTRONOMICAL MULTIBAND IMAGE FUSION AND RESTORATION USING MARKOV QUADTREE AND COPULAS

    Computer Technologies and Information Sciences Websites

    : Masses de Donn´ees en Astronomie : http://cdsweb.u- strasbg.fr/MDA/mda.html ). Fig. 1. Fusion Fusion of multiband images is of great interest in several ap- plications like astronomy, remote sensing] which allows us to use any kind of marginal densities with a given interband corre- lation. The proposed

  11. SPATIAL DATABASE MODELING WITH PICTOGRAMMIC LANGUAGES Yvan Bdard, Suzie Larrive

    Geosciences Websites

    using CASE tools (computer-assisted software engineering). CASE tools support schema drawing. For example, in the standard Model-Driven Architecture (MDA) method (http://www.omg.org/mda/), these three countries, Software Development Process Model with Objecteering [14], MADS [17], CONGOO [16], UML

  12. Genotyping in DNA pools reduces the cost and the time required to complete large genotyping

    Biology and Medicine Websites

    Nyholt, Dale R.

    Genotyping in DNA pools reduces the cost and the time required to complete large genotyping of each individual DNA sample before mixing aliquots. Pools were also constructed by combining DNA after Multiple Displacement Amplification (MDA). The MDA pools gave similar results to pools constructed after

  13. Optimization Problem Solving System using Grid RPC Tomoyuki HIROYASU Mitsunori MIKI Hisashi SHIMOSAKA

    Computer Technologies and Information Sciences Websites

    Dongarra, Jack

    Gradient Method Analyzer FEM CFD MDA Data Result Figure 1: Optimization System the concept and overview Data of FEM (4)Result of FEM (2) Infomation of FEM Server (1) Search for FEM Server Optimizer Analyzer SA FEM CFD MDA GA SQP Figure 2: Overview of Proposed System using Grid RPC 2.1 System Construction

  14. WEIGHTED UNIFORM CONSISTENCY OF KERNEL DENSITY ESTIMATORS by Evarist Gine,1

    Mathematics Websites

    Zinn, Joel

    -norm. 1. Research partially supported by NSF Grant No. DMS-0070382. 2. Research partially supported by NSA Grant No. MDA904-99-1-0031. 3. Research partially supported by NSA Grant No. MDA904-01-1-0027. 1 #12

  15. The locus of curves with prescribed automorphism group April 24, 2002

    Mathematics Websites

    of the corresponding loci in M g , see Table 4. 1 Partially supported by NSA grant MDA904-01-1-0037 2 Partially supported by NSA grant MDA904-01-1-0023 3 Partially supported by NSF grant DMS-9970357 1 #12; The locus

  16. Convexi cation of Planar Polygons in R 3 Boris Aronov ,

    Computer Technologies and Information Sciences Websites

    Aronov, Boris

    York, NY 10031, U.S.A. (jegcc@cunyvm.cuny.edu). Supported in part by NSA Grant MDA904-98-I-0032 and PSC-9732101 and NSA Grant MDA904-98-I-0505. 1 #12; Proof of Key Observation. Consider #12;rst the convex case

  17. Regulus--free Spreads of PG(3; q) R. D. Baker*

    Mathematics Websites

    Ebert, Gary

    algebra and the arithmetic of finite fields. * This work was partially supported by NSA grant MDA 904­95­H­1013 ** This work was partially supported by NSA grant MDA 904­94­H­2033. #12; Regulus--free Spreads 1

  18. Site environmental report for 2001

    University of California eScholarship Repository

    Pauer, Ron

    2002-01-01

    Type mg/L mg/L Sample Sample General Indicator Parameters Total suspended solids (TSS) 69-StormStorm Drain Manhole Chicken Creek A-109 • Stormwater Result MDA or PQL Units QC TypeStorm Drain Manhole Beryllium A-107 • Stormwater Analyte Location Date Result MDA or PQL Units QC Type

  19. LANL completes excavation of 1940s waste disposal site

    Physics Websites

    from the six-acre site. MDA-B was used from 1944-48 as a waste disposal site for the Manhattan Project completion of the excavation of MDA-B is a landmark for our Recovery Act projects and environmental cleanup of the Recovery Act projects at the Lab. "Safety for the public, the environment, and our workers was always our

  20. Life Sciences, Vol. 35, pp. 1297-1300 Printed in the U.S.A.

    Biology and Medicine Websites

    Wurtman, Richard

    , isocaloric, isonitrogenous diets differing in carbohydrate content. Three of the test agents, d- amphetamine) In carbohydrate. In contrast, MK-212 and d-fenfluramlne fal led to reduce consumption of the 25% dextrin test diet simultaneously, that enhanced serotoninergic neurotransmlssion selectively suppresses appetite for carbohydrates

  1. Sensory gating deficits, pattern completion, and disturbed fronto-limbic balance, a model for

    Biology and Medicine Websites

    Bruno, John P.

    disorder, posttraumatic stress disorder, obsessive compulsive, and amphetamine and drug-induced psychotic disorders. Based on the postulated model, a spectral view on these disorders with psychotic features is also and psychotic disorders and relation between schizophrenia and bipolar mood disorder in anatomy and neural

  2. Journal of Chromatography B, 879 (2011) 541547 Contents lists available at ScienceDirect

    Biology and Medicine Websites

    California at San Diego, University of

    2011-01-01

    metabolite amphetamine (AP) in hair were determined using gas chromatography/mass spectrometry (GC/MS). One of drug use and the con- centration of the drug in hair still remains controversial. Forensic scientists to a substantive individual bio- variability, variability of hair-growth cycles, hair color, cosmetic treatment

  3. Dopamine transport currents are promoted from curiosity to

    Biology and Medicine Websites

    Sulzer, David

    for cocaine and amphetamine action, and its activity determines the length of time that dopamine is present by the DAT antagonists cocaine or GBR12909, providing evidence that, as is the case for NET, the transporter to be due to a cocaine- sensitive inward current. The size of this dopamine- induced DAT-mediated current

  4. Computational Psychiatry Rising (on the shoulder of reinforcement learning and

    Biology and Medicine Websites

    Seriès, Peggy

    ­deficienEffects of Drugs of Abuse self-administer cocaine d Drug of Abuse Neurotransmitter Sites of extracellular dopami Cocaine and Dopamine Nucleus accumbens fields, suggesting a more amphetamines Serotonin Amygdala stimulant the reinforcing prop- The reinforcing proper erties of cocaine (Woolverton and Johnson, 1992; Caine circuitry

  5. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) BIOGRAPHICAL SKETCH

    Biology and Medicine Websites

    West, Mark O.

    -sucrose conditioning, and intravenous cocaine self-administration, which is abolished by NAc lesions as shown of dopamine transmission, administration of the psychomotor stimulants cocaine and amphetamine as their corruption by chronic cocaine self-administration, with the aim of informing treatment strategies

  6. by popular demand: Addiction II

    Computer Technologies and Information Sciences Websites

    Niv, Yael

    in an aberrant way · e.g., drugs increase availability of dopamine (directly: amphetamine, cocaine or indirectly intravenous self-administration of cocaine (nose-poking, FR5) in rats, for long periods (3 months) · divide) progression from casual to compulsive drug use tone CS paired with footshock: will it inhibit cocaine seeking

  7. Neuroscience Letters 468 (2010) 1822 Contents lists available at ScienceDirect

    Biology and Medicine Websites

    Anagnostaras, Stephan

    2010-01-01

    Letters journal homepage: www.elsevier.com/locate/neulet Amphetamine and extinction of cued fear Stephanie the acquisition of cued fear. The current experiment sought to expand these findings to the extinction of cued-traumatic stress disorder. If extinction reflects new learning, one might expect drugs that enhance the acquisition

  8. Neuron, Vol. 42, 653663, May 27, 2004, Copyright 2004 by Cell Press Heterosynaptic Dopamine Neurotransmission

    Biology and Medicine Websites

    Sulzer, David

    Neuron, Vol. 42, 653­663, May 27, 2004, Copyright 2004 by Cell Press Heterosynaptic Dopamine Center configuration suggests that dopamine release, which isSeattle, Washington 98105 elicited or by dopamine-3 Department of Psychiatry releasing drugs such as amphetamine, may not only4 Center

  9. Z .Brain Research 835 1999 2736 www.elsevier.comrlocaterbres

    Biology and Medicine Websites

    California at San Diego, University of

    behavior is a standard methodology to characterize the behavioral phenotype of a genetic manipulation manipulations ranging from genetic changes, e.g. knockout mice, to pharmacological challenges, e.g. amphetamine to establish the phenotype for various genetic manipulations of mice. Nevertheless, as pointed out by others

  10. A rt i c l e s 566 VOLUME 17 | NUMBER 5 | MAY 2011 nAture medicine

    Biotechnology Websites

    Jeong, Jaeseung

    memory, which are all reversed by amphetamines. RAC1 signaling and inhibitory presynaptic input with ADHD and 196 age-matched controls; Supplementary Table 1) for 27 SNPs in a 19-kilobase (kb) region) is a psychiatric disorder that affects ~5% of school-aged children; however, the mechanisms underlying ADHD remain

  11. From HEALTH TOPICS on the UHS Web site www.rochester.edu/uhs

    Biology and Medicine Websites

    Cantlon, Jessica F.

    (henceforth referred to as "meth") is a synthetic drug illegally produced and sold with a high potential for abuse and dependence. A derivative of amphetamine, meth was first developed in the early 20th century. In the 1970s meth became a Schedule II drug, classifying it as a drug with little medical use and high

  12. Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs

    University of Cambridge - Dspace

    Heath, Christopher; Bussey, Timothy; Saksida, Lisa M.

    2015-07-10

    stabilised within 7 sessions. Amphetamine (1mg/kg) increased and raclopride (0.3mg/kg) decreased performance by 63% and 28% respectively with a 20 minute injection-test interval. Sulpiride (50mg/kg) decreased performance by 19% following a 40 minute injection...

  13. Z .Brain Research 745 1997 331335 Short communication

    Biology and Medicine Websites

    West, Mark O.

    Z .Brain Research 745 1997 331­335 Short communication Low-dose amphetamine elevates movement that of the stimulant effect on these movements. Elevation of movement-related striatal firing rates by low doses 6,15 , and measures of striatal activity w x9,18,24,31 . A missing link is the characterization

  14. Behavioural Brain Research 114 (2000) 2330 Research report

    Biology and Medicine Websites

    Timberlake, William D.

    2000-01-01

    Science B.V. All rights reserved. Keywords: Predatory behavior; Amphetamine; Apomorphine; Eticlopride; SCHBehavioural Brain Research 114 (2000) 23­30 Research report Facilitation of preparatory behavior in Neural Science and Department of Psychology, Indiana Uni6ersity at Bloomington, 1101 E. Tenth St

  15. Assessing Regional Border Security 

    Texas A&M University - TxSpace

    Causey, Chris; Hahn, Jason; Heichelbach, Terry; Malecha, Lindsay; Meiners, Stephen; Race, Brandon

    2009-01-01

    of illegal immigration, we used the number of illegal immigrants apprehended. To determine the volume of drug smuggling, we used the amount of drugs (marijuana, opiates, cocaine, other, and total) seized. Our assumption is that the majority of many types... of drugs enter the U.S. through Mexico. The National Drug Intelligence Center estimates that approximately 90% of cocaine enters the U.S. from Mexico, as do large but unestimated quantities of marijuana and methamphetamines (DOJ 4 2008, 2). In our...

  16. Compositional Modeling for Data-Centric Business Applications

    Mathematics Websites

    Borgs, Christian

    ]. A number of approaches have been suggested to address these issues: Model- driven architecture (MDA) [4] attempts to disentangle the implementation plat- form from the business logic, enterprise patterns [5

  17. This is the author version published as: This is the accepted version of this article. To be published as

    Computer Technologies and Information Sciences Websites

    Liang, Huizhi "Elly"

    Repository: http://eprints.qut.edu.au/ Gerber, Anna, Lawley, Michael J., Raymond, Kerry, Steel, Jim, & Wood of MDA Anna Gerber, Michael Lawley, Kerry Raymond, Jim Steel, and Andrew Wood {agerber,lawley,kerry,steel

  18. An Aspect Oriented Model Driven Framework Devon Simmonds

    Computer Technologies and Information Sciences Websites

    Simmonds, Devon M.

    presents an aspect oriented model driven framework (AOMDF) that facilitates separation of pervasive, middleware, model driven development, separation of concerns, transactions, UML. 1 Introduction Model driven supporting both vertical and horizontal separation of concerns. The model driven architecture (MDA) [1

  19. The role of the homeodomain protein Pitx3 in the development and survival of midbrain dopaminergic neurons. 

    Edinburgh, University of - Research Archive

    Maxwell, Sarah L

    There is much interest in the study of midbrain dopaminergic (mDA) neurons as their functions include the regulation of motor function, emotion and reward pathways. Furthermore the dysfunction of these neurons is implicated ...

  20. A N U A R I O C I N V E S T A V780 DEPARTAMENTO DE ECOLOGA HUMANA

    Mathematics Websites

    investigaciones del Departamento se orientan hacia dos áreas principales: Uso social de los ecosistemas, que ecosistemas. Categoría en el SNI: Nivel I batllori@mda.cinvestav.mx ERIC JOHN CASTAÑARES MADDOX Investigador

  1. Fast Rates for Regularized Least-squares Algorithm

    Biology and Medicine Websites

    Poggio, Tomaso

    (CSAIL). This research was sponsored by grants from: Office of Naval Research (DARPA) Contract No. MDA972-04-1-0037, Office of Naval Research (DARPA) Contract No. N00014-02-1-0915, National Science Foundation (ITR

  2. Ultra-fast Object Recognition from Few Spikes

    Biology and Medicine Websites

    Poggio, Tomaso

    was sponsored by a Whiteman Fellowship and the Government grant from the Office of Naval Research (DARPA) Contract No. MDA972-04-1-0037, Office of Naval Research (DARPA) Contract No. N00014-02-1-0915, National

  3. Terahertz radiation by optical rectification in a hydrogen-bonded organic molecular ferroelectric crystal, 2-phenylmalondialdehyde

    CERN Preprints

    Guan, W; Sotome, M; Kinoshita, Y; Takeda, R; Inoue, A; Horiuchi, S; Okamoto, H

    2014-01-01

    Terahertz radiation by optical rectification has been observed at room temperature in a hydrogen-bonded organic molecular ferroelectric crystal, 2-phenyl malondialdehyde (PhMDA). The radiated electromagnetic wave consisted of a single-cycle terahertz pulse with a temporal width of $\\sim$ 0.5 ps. The terahertz radiation amplitude divided by the sample thickness in PhMDA was nearly equivalent to that in a typical terahertz wave emitter ZnTe. This is attributable to a long coherence length in the range of 130 $\\sim$ 800 $\\mu$m for the terahertz radiation from PhMDA. We also discussed the possibility of PhMDA as a terahertz wave emitter in terms of the phase-matching condition.

  4. Transformations based on Relations D.H.Akehurst

    Computer Technologies and Information Sciences Websites

    Kent, University of

    .H.Akehurst@kent.ac.uk The Model Driven Architecture (MDA) is an approach to IT systems development fostered by the Object of one relation to be in the context of an element from its parent relation, and facilitates reuse

  5. The "Graviton Picture": a Bohr Model for Gravitation on Galactic Scales?

    Physics (arXiv)

    Sascha Trippe

    2014-05-06

    Modified Newtonian Dynamics (MOND) provides a successful description of stellar and galactic dynamics on almost all astronomical scales. A key feature of MOND is the transition function from Newtonian to modified dynamics which corresponds to the empirical mass discrepancy--acceleration (MDA) relation. However, the functional form of the MDA relation does not follow from theory in a straightforward manner; in general, empirical MDA relations are inserted ad hoc into analyses of stellar dynamics. I revisit the possibility of gravity being mediated by massive virtual particles, gravitons. Under certain reasonable assumptions, the resulting "graviton picture" implies a MDA relation that is equivalent to the - empirical - "simple mu" function of MOND which is in very good agreement with observations. I conclude that the "graviton picture" offers a simple description of gravitation on galactic scales, potentially playing a role for gravitation analogous to the role played by Bohr's model for atomic physics.

  6. This major integrates all of the necessary science, social science, humanities, and critical thinking concepts, as well as field experience, needed in order to educate

    Chemistry Websites

    Krylov, Anna I.

    Courses HBIO 405: Evolutionary Medicine -- Evolutionary, cultural, and environmental factors Principle of Biochemistry HIST 330: Drugs, Diseases and Medicine in History HBIO 405: Evolutionary Medicine MDA 320: Global Ethics: Poverty, Health, and the Human Condition *This information is offered

  7. Cold Spring Harbor Laboratory Press NATURE METHODS | VOL.2 NO.7 | JULY 2005 | 557 CLASSIC PROTOCOL

    Chemistry Websites

    Cai, Long

    ) DNA by electrophoresis through a nondenaturing polyacrylamide gel. The protein retards the mobility greater than 1 MDa in mass are difficult to resolve and migrate quite slowly in the native polyacrylamide

  8. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression

    Biology and Medicine Websites

    Strominger, Jack L.

    activity of SWI SNF proteins. In fact, Brahma (BRM), a trx-G family gene, itself, encodes a SWI SNF ATPase domain. BRM recruits more than seven other SWI SNF proteins to form a 2-MDa complex that is found

  9. vgrserver.cse.yorku.ca Canadian Centre

    Computer Technologies and Information Sciences Websites

    -robot communication device developed in the lab, allows divers to safely operate robots. Working in collaboration with MDA, the RCMP and a number of other police forces, we are developing tools that can collect

  10. The "Graviton Picture": a Bohr Model for Gravitation on Galactic Scales?

    CERN Preprints

    Trippe, Sascha

    2014-01-01

    Modified Newtonian Dynamics (MOND) provides a successful description of stellar and galactic dynamics on almost all astronomical scales. A key feature of MOND is the transition function from Newtonian to modified dynamics which corresponds to the empirical mass discrepancy--acceleration (MDA) relation. However, the functional form of the MDA relation does not follow from theory in a straightforward manner; in general, empirical MDA relations are inserted ad hoc into analyses of stellar dynamics. I revisit the possibility of gravity being mediated by massive virtual particles, gravitons. Under certain reasonable assumptions, the resulting "graviton picture" implies a MDA relation that is equivalent to the - empirical - "simple mu" function of MOND which is in very good agreement with observations. I conclude that the "graviton picture" offers a simple description of gravitation on galactic scales, potentially playing a role for gravitation analogous to the role played by Bohr's model for atomic physics.

  11. www.sciencesignaling.org/cgi/content/full/8/358/ra1/DC1 Supplementary Materials for

    Chemistry Websites

    Walter, Nils G.

    of a selected pathway, the oocyte meiosis pathway (middle and bottom) in A549-BTR cells (B) and MDA-231-1833-BTR. Oocyte meiosis pathway analysis (middle) shows the highest total perturbation accumulation (pA for BUB1

  12. Realistic Modeling of Simple and Complex Cell Tuning in

    Biology and Medicine Websites

    Riesenhuber, Maximilian

    of the architecture at the top level to replicate shape tuning as well as shift and size invari- ance properties of Naval Research (DARPA) Contract No. MDA972-04-1-0037, Office of Naval Research (DARPA) Contract No. N

  13. MKV Carrier Vehicle Sensor Calibration

    MIT - DSpace

    Plotnik, Aaron M.

    The Multiple Kill Vehicle (MKV) system, which is being developed by the US Missile Defense Agency (MDA), is a midcourse payload that includes a carrier vehicle and a number of small kill vehicles. During the mission, the ...

  14. April 5, 2010 Department of Mathematics Telephone: 319/335-0717

    Biology and Medicine Websites

    Ye, Yangbo

    . · 3/2006-3/2008 NSA grant, PI, Bounds for automorphic L-functions, their zeros, func- toriality University. · 2/20032/2005 NSA Grant MDA904-03-1-0066, PI, Zeros and Subconvexity of L- Functions. · 12

  15. CURRICULUM VITAE Spyros S. Magliveras

    Mathematics Websites

    Magliveras, Spyros

    ), an NSA/DHS designated National Center of Academic Excellence in Information Assurance Research , Florida in Computer Science, Summer, 1982. 14. Director, NSF/NSA Research Grant # MDA904-82-H-001, 1982-84, $61

  16. Structural studies of large architectural nucleoporins and coat proteins

    MIT - DSpace

    Whittle, James Richardson Ross

    2010-01-01

    The Nuclear Pore Complex (NPC) is a ~50 MDa protein complex that forms the sole conduit for macromolecular transport across the nuclear envelope. It assembles from ~30 proteins, termed nucleoporins or nups, symmetrically ...

  17. Flow Analysis for Verifying Specifications of Concurrent and Distributed Software \\Lambda

    Computer Technologies and Information Sciences Websites

    Massachusetts at Amherst, University of

    University University of Massachusetts Manhattan, KS 66506 Amherst, MA 01003 dwyer@cis.ksu.edu clarke This work was supported by the Advanced Research Projects Agency under Grant MDA972­91­J­1009, the Office

  18. Flow Analysis for Verifying Speci cations of Concurrent and Distributed Software

    Computer Technologies and Information Sciences Websites

    Massachusetts at Amherst, University of

    University of Massachusetts Manhattan, KS 66506 Amherst, MA 01003 dwyer@cis.ksu.edu clarke was supported by the Advanced Research Projects Agency under Grant MDA972-91-J-1009, the O ce of Naval Research

  19. Supporting Information Polytarchou et al. 10.1073/pnas.1212811109

    Biology and Medicine Websites

    - Fig. S4. ER, PR, and HER2 status in breast cancer cell lines and human tissues. Polytarchou et al. www MDA-MB-436 and MDA-MB-231 cancer cells, 48 h post transfection with (A) antisense and (B) sense miScan v5.1 program. Fig. S3. Suz12, Zeb2, Bmi1, and Klf4 mRNA expression levels in breast cancer stem

  20. Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2006

    Chemistry Websites

    Hergenrother, Paul J.

    800 900 B16-F10 B16-F10 13-D RFU Count 0.1 1 10 100 1000 S3 #12;0 200 400 600 800 1000 1200 MDA-MB-231 MDA-MB-231 13-D RFU Count 0.1 1 10 100 1000 0 200 400 600 800 1000 1200 1400 1600 UACC-62 UACC-62 13-D

  1. Dopamine Release and Uptake in Animal Models of Neurological Diseases

    University of Kansas - KU ScholarWorks

    Fulks, Jenny Lynn

    that alter DA release and uptake can be used to evaluate neurological diseases and disorders in FSCV brain slice experiments. Some 25 of the common drugs used include amphetamine and cocaine. Other Drugs used in this study include GBR 12909, quinpirole... of the synapse, AMPH causes the depletion of vesicular DA by binding interaction with VMAT2, causing more extracellular DA, which can be outwardly transported by DAT (77). Cocaine, an addictive stimulant found in the leaves of the coca plant, has been...

  2. Relating Kansas Offenses

    University of Kansas - KU ScholarWorks

    Stacy, Tom

    2008-05-01

    on the ground that it was compelled by legal text. Even indulging the assumption that the term "compounding" has exactly the same meaning in the distribution and manufacture offenses, McAdam requires the additional premise that the punishment for identical... the culpability already inherent in the manufacture. Additional 59. 133 P.3d 48, 81 (Kan. 2006); cf State v. Patten, 122 P.3d 350, 355 (Kan. 2005) (holding that offenders may be convicted of both methamphetamine manufacture and possession of drug paraphernalia...

  3. Can Massive Gravity Explain the Mass Discrepancy - Acceleration Relation of Disk Galaxies?

    CERN Preprints

    Trippe, Sascha

    2013-01-01

    The empirical mass discrepancy-acceleration (MDA) relation of disk galaxies provides a key test for models of galactic dynamics. In terms of modified laws of gravity and/or inertia, the MDA relation quantifies the transition from Newtonian to modified dynamics at low centripetal accelerations a_c < 10^-10 m/s^2. As yet, neither dynamical models based on dark matter nor proposed modifications of the laws of gravity/inertia have predicted the functional form of the MDA relation. In this work, I revisit the MDA data and compare them to four different theoretical scaling laws. Three of these scaling laws are entirely empirical, the fourth one - the "simple mu" function of Modified Newtonian Dynamics - derives from a toy model of gravity based on massive gravitons (the "graviton picture"). All theoretical MDA relations comprise one free parameter of the dimension of an acceleration, Milgrom's constant a_M. I find that the "simple mu" function provides a good fit to the data free of notable systematic residuals ...

  4. Galactic rotation curves, the baryon-to-dark-halo-mass relation and space-time scale invariance

    CERN Preprints

    Wu, Xufen

    2014-01-01

    Low-acceleration space-time scale invariant dynamics (SID, Milgrom 2009a) predicts two fundamental correlations known from observational galactic dynamics: the baryonic Tully-Fisher relation (BTFR) and a correlation between the observed mass discrepancy and acceleration (MDA) in the low acceleration regime for disc galaxies. SID corresponds to the deep MOND limit (Milgrom 1983c). The MDA data emerging in cold/warm dark matter (C/WDM) cosmological simulations disagree significantly with the tight MDA correlation of the observed galaxies. Therefore, the most modern simulated disc galaxies, which are delicately selected to have a quiet merging history in a standard dark-matter-cosmological model, still do not represent the correct rotation curves. Also, the observed tight correlation contradicts the postulated stochastic formation of galaxies in low-mass DM halos. Moreover, we find that SID predicts a baryonic to apparent virial halo (dark matter) mass relation which agrees well with the correlation deduced obse...

  5. Can Massive Gravity Explain the Mass Discrepancy - Acceleration Relation of Disk Galaxies?

    General Relativity & Quantum Cosmology (arXiv)

    Sascha Trippe

    2013-05-28

    The empirical mass discrepancy-acceleration (MDA) relation of disk galaxies provides a key test for models of galactic dynamics. In terms of modified laws of gravity and/or inertia, the MDA relation quantifies the transition from Newtonian to modified dynamics at low centripetal accelerations a_c < 10^-10 m/s^2. As yet, neither dynamical models based on dark matter nor proposed modifications of the laws of gravity/inertia have predicted the functional form of the MDA relation. In this work, I revisit the MDA data and compare them to four different theoretical scaling laws. Three of these scaling laws are entirely empirical, the fourth one - the "simple mu" function of Modified Newtonian Dynamics - derives from a toy model of gravity based on massive gravitons (the "graviton picture"). All theoretical MDA relations comprise one free parameter of the dimension of an acceleration, Milgrom's constant a_M. I find that the "simple mu" function provides a good fit to the data free of notable systematic residuals and provides the best fit among the four scaling laws tested. The best-fit value of Milgrom's constant is a_M = (1.06 +/- 0.05)*10^-10 m/s^2. Given the successful prediction of the functional form of the MDA relation, plus an overall agreement with the observed kinematics of stellar systems spanning eight orders of magnitude in size and 14 orders of magnitude in mass, I conclude that the "graviton picture" is sufficient (albeit probably not a necessary or unique approach) to describe galactic dynamics on all scales well beyond the scale of the solar system. This suggests that, at least on galactic scales, gravity behaves as if it was mediated by massive particles.

  6. Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro

    University of Kansas - KU ScholarWorks

    Ndolo, Rosemary A.; Laun, Yepeng; Duan, Shaofeng; Forrest, Laird; Krise, Jeffrey P.

    2012-11-07

    been shown to have defective acidification of lysosomes, we found that a number of them maintain normally acidified lysosomes. For example, the MDA-MB-231 breast adenocarcinoma cell line maintains a lysosomal pH of 4.2, similar to the lysosomal p... the expression of a subunit of this enzyme, using siRNA, yielded cells with altered V-ATPase proton pumping activity, with no effect on cell proliferation [31]. We utilized a similar technique to create MDA-MB-231 cells with elevated lysosomal pH. Specifically...

  7. Excitation of Giant Monopole Resonance in $^{208}$Pb and $^{116}$Sn Using Inelastic Deuteron Scattering

    Nuclear Experiment (arXiv)

    D. Patel; U. Garg; M. Itoh; H. Akimune; G. P. A. Berg; M. Fujiwara; M. N. Harakeh; C. Iwamoto; T. Kawabata; K. Kawase; J. T. Matta; T. Murakami; A. Okamoto; T. Sako; K. W. Schlax; K. Takahashi; M. White; M. Yosoi

    2014-06-26

    The excitation of the isoscalar giant monopole resonance (ISGMR) in $^{116}$Sn and $^{208}$Pb has been investigated using small-angle (including $0^\\circ$) inelastic scattering of 100 MeV/u deuteron and multipole-decomposition analysis (MDA). The extracted strength distributions agree well with those from inelastic scattering of 100 MeV/u $\\alpha$ particles. These measurements establish deuteron inelastic scattering at E$_d \\sim$ 100 MeV/u as a suitable probe for extraction of the ISGMR strength with MDA, making feasible the investigation of this resonance in radioactive isotopes in inverse kinematics.

  8. Effectiveness of the GT200 Molecular Detector: A Double-Blind Test

    CERN Preprints

    Mochán, W Luis

    2013-01-01

    The GT200 is a device that has been extensively used by the Mexican armed forces to remotely detect and identify substances such as drugs and explosives. A double blind experiment has been performed to test its effectivity. In seventeen out of twenty attempts, the GT200 failed in the hands of certified operators to find more than 1600 amphetamine pills and four bullets hidden in a randomly chosen cardboard box out of eight identical boxes distributed within a 90m$\\times$20m ballroom. This result is compatible with the 1/8 probability expected for a completely ineffectual device, and is incompatible with even a moderately effective working one.

  9. Octomeric pyruvate-ferredoxin oxidoreductase from Desulfovibrio vulgaris

    Environmental Sciences and Ecology Websites

    Hazen, Terry

    image analysis, homology modeling and computational molecular docking. Our results show that the 1 MDa bacteria, this central step in energy metabolism is catalyzed by the pyruvate dehydrogenase multi-enzyme complex. In most anaerobic bacteria, archaea, and eukaryotes that lack mitochondria, however, this step

  10. Combined Analysis of Polycation/ODN Polyplexes by Analytical Ultracentrifugation and Dynamic Light Scattering Reveals their Size,

    Biology and Medicine Websites

    Buschmann, Michael

    polyplexes formed with 10 kDa chitosan or 10 kDa PEI and oligodeoxynucleotides (ODN). Combined analysis diameters were of 46 and 55 nm for chitosan/ODN and PEI/ODN complexes, respectively. Transformation weight of 19 and 29 MDa for chitosan and PEI polyplexes, respectively. Data from AUC also allowed

  11. Modelling and Analysis Methods and Tools to Support Mobile Robotics Design and Control B. Ghotbi, F. Gonzlez, A. Azimi,

    Mathematics Websites

    Font, Josep Maria

    comparison of different rover designs Objectives Curiosity (NASA) CBR (MDA) ExoMars (ESA) Access to dynamic terms Choice of various multibody dynamics formulations and integrators Solution to non in forward- and inverse-dynamics settings Graphic representation capabilities General Purpose Multibody

  12. Protein Interactions DOI: 10.1002/anie.201405180

    Biology and Medicine Websites

    Clore, G. Marius

    and position-specific bind- ing probabilities for amyloid b (Ab) monomers in exchange with large (2­80 MDa) protofibrillar Ab aggregates. Here we use 13 Cmethyl DEST and lifetime line-broadening to probe the interactions and dynamics of methyl-bearing side chains in the Ab-protofibril-bound state. We show that all methyl groups

  13. ENUMERATIVE GEOMETRY OF DIVISORIAL FAMILIES OF RATIONAL CURVES

    Mathematics Websites

    Ran, Ziv

    ENUMERATIVE GEOMETRY OF DIVISORIAL FAMILIES OF RATIONAL CURVES Ziv Ran 1/27/04 Abstract. We compute machinery of Quantum Cohomology (cf. e.g. [FP]). Subsequently, in a series of papers [R2-R5] the author and corrections available at math.ucr.edu/~ ziv/papers/1nodal.pdf. Research Partially supported by NSA Grant MDA

  14. A dominant nuclear mutation in Chlamydomonas identies a factor controlling chloroplast mRNA stability by acting on

    Renewable Energy Websites

    A dominant nuclear mutation in Chlamydomonas identi®es a factor controlling chloroplast m 33 1 58 41 50 12; e-mail Wollman@ibbc.fr) Summary We have characterized a nuclear mutation, mda1-ncc1, that affects mRNA stability for the atpA gene cluster in the chloroplast of Chlamydomonas. Unlike all nuclear

  15. brief communications 332 | VOL.10 NO.4 | APRIL2013 | nature methods

    Biology and Medicine Websites

    Cai, Long

    nucleons, is different for each isotope of every element15. The tandem mass tag approach still relies on MS can be induced with many elements and their isotopes: for example, 12C/13C (+3.3 mDa), 1H/2H (+6.3 m incorpora- tion of these isotopes into proteomes would generate a new MS1- centric quantification technology

  16. Microfluidic Whole Genome Amplification Device for Single Cell Zhilong Yu,

    Materials Science Websites

    Huang, Yanyi

    - to microgram DNA fragments from a single cell. Among these methods, polymerase chain reaction (PCR)-based WGA (for example, DOP-PCR)11,12 and multiple displacement amplifica- tion (MDA)13,14 have shown promising the likelihood of contamination. Such a feature is previously demonstrated by quantitative PCR,18

  17. M I C H I G A N News you can use

    Biology and Medicine Websites

    Isaacs, Rufus

    to kill fruit fly adults and fruitworm larvae migrating from infested berries in a cluster. Mummyberry in the statewide MDA virus survey, which ends on July 16. Monitor fields for signs of mummy berry fruit infection and cane collapse. Protect fruit from anthracnose, Alternaria, and other fruit rots with broad

  18. Abstract--Micro assembly refers to the assembly and manipulation of micron sized devices. This paper discusses an

    Computer Technologies and Information Sciences Websites

    Calyam, Prasad

    Abstract-- Micro assembly refers to the assembly and manipulation of micron sized devices scenarios and camera monitoring tasks among the distributed resources. I. INTRODUCTION Micro Devices Assembly (MDA) refers to assembly of micro devices for various engineering and other application contexts

  19. High-Dimensional Extremes and Copulas lih@math.wsu.edu

    Mathematics Websites

    Li, Haijun

    , January 3, 2014 8 / 72 #12;Generalized Extreme Value Distribution (EV) Fisher-Tippett-Gnedenko Theorem, 2014 1 / 72 #12;Outline 1 From Tukey to High-Dimensional Data Analysis 2 Univariate Extreme Value If F MDA(H), then H(x; ) = exp{-(1 + x) -1/ + }, x R, where R is called the extreme value index

  20. Justin Ellis Short Memo 2

    Environmental Sciences and Ecology Websites

    Radcliffe, David

    water users should consult with several entities and a lawyer versed in water law (Loudon 2003). GAAMPS, Michigan adopted their first Right to Farm Act, a law designed to protect farmers from nuisance lawsuits and Cheney 2000). This law authorized the Michigan Department of Agriculture (MDA) to develop Generally

  1. Convex Hull Asymptotic Shape Evolution Maxim Arnold, Yuliy Baryshnikov and Steven M. LaValle

    Mathematics Websites

    Baryshnikov, Yuliy

    ] have become increasingly popular as a way to explore high-dimensional spaces for problems in robotics, Russia). Email: {mda,ymb,lavalle}@uiuc.edu Summary. The asymptotic properties of Rapidly exploring Random Tree (RRT) growth in large spaces is studied both in simulation and analysis. The main phenomenon

  2. 2012 Dry Bean Research Report

    Renewable Energy Websites

    2012 Dry Bean Research Report Assessment of Narrow Row Technology Michigan Dry Edible Bean Production Research Advisory Board #12;The Michigan Bean Commission was awarded a grant from the MDA Technology for the Michigan Dry Bean Industry". Expected outcomes from this project are: 1. Identification

  3. 2010 Dry Bean Research Report

    Environmental Sciences and Ecology Websites

    2010 Dry Bean Research Report Assessment of Narrow Row Technology Michigan Dry Edible Bean Production RESEARCH ADVISORY BOARD #12;The Michigan Bean Commission was awarded a grant from the MDA Technology for the Michigan Dry Bean Industry". Expected outcomes from this project are: 1. Identification

  4. A structural perspective on proteinprotein interactions Robert B Russell1,2

    Biology and Medicine Websites

    Eddy, Sean

    that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness. Addresses 1]. For instance, the nuclear pore complex, a 50­100 MDa protein assembly, regulates and controls the trafficking]. Macromolecular assemblies are also involved in tran- scription control (e.g. the IFNb enhanceosome) [6

  5. Genes and Immunity (2000) 1, 358361 2000 Macmillan Publishers Ltd All rights reserved 1466-4879/00 $15.00

    Biology and Medicine Websites

    2000-01-01

    Manni1 , LG Kostrikis2 and AU Neumann4 1 Hadassah Hospital, Jerusalem 91000, Israel; 2 The Aaron Diamond AIDS Research Center, New York, NY 10016, USA; 3 MDA ­ Israel National Blood Services, Ramat the prevalence of CCR5- 32 in 922 HIV seronegative blood donors in Israel to verify its frequency in Jews

  6. Integrated Model-Based Software Development, Data Access, and Data Migration

    Computer Technologies and Information Sciences Websites

    Bordbar, Behzad

    migration. In general, Model Driven Architecture (MDA) [1, ?,?] combined with round trip engineering can development and simultaneous roundtrip engineering, (ii) transparent database access and (iii) data migration. This results in an architecture that adds a transparent database accessing layer between application logic

  7. 498 IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, VOL. 4, NO. 3, MAY/JUNE 1998 Characteristics of InGaNAlGaN

    Physics Websites

    McCluskey, Matthew

    illumination. Similarly, lasers of these primary colors may also be incorporated in full- color film printers was supported in part by the Defense Advanced Research Projects Agency under Contract MDA972-96-0014 (Blue BAND-recordable systems and for high- speed high-resolution laser printers. Accordingly, this paper is a description

  8. From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects

    Biology and Medicine Websites

    Yonath, Ada E.

    -protein trafficking into the chap- eron-aided folding site. Conformational alterations, induced by ribosomal-recycling effectiveness. Ó 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights; Ribosome-recycling factor 1. Symmetry within the asymmetric ribosome The ribosome, a 2.5 MDa riboprotein

  9. RESEARCH ARTICLE Open Access Integration of mate pair sequences to improve

    Biology and Medicine Websites

    Schierup, Mikkel Heide

    of the bread wheat genome sequence is challenging due to allohexaploidy and extreme repeat content (>80 construction. Keywords: Wheat, Assembly, Scaffold, Mate-pair, MDA, Improvement Background Bread wheat is one-2164/14/222 #12;large size (17Gb) and the complexity of the hexaploid wheat genome. Bread wheat is allohexap

  10. Asymptotics of Gaussian Regularized Least-Squares

    Biology and Medicine Websites

    Poggio, Tomaso

    (CSAIL). This research was sponsored by grants from Office of Naval Research (DARPA) Contract No. MDA972-04-1-0037, Office of Naval Research (DARPA) Contract No. N00014-02-1-0915, Na- tional Science Foundation-NIH (CRCNS

  11. 486 IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, VOL. 9, NO. 2, MARCH/APRIL 2003 Wavelength Division Multiplexed Optical

    Engineering Websites

    Miller, David A. B.

    Advanced Research Projects Agency (DARPA) under Ultra-Photonics Program Grant F49620-97-1-0517, by DARPA Grant MDA972-98-1-0002, by MARCO/DARPA Grant GIT-B-12-D00-S57, and a subaward from the University of New

  12. HOCHSCHILD COHOMOLOGY AND LINCKELMANN COHOMOLOGY FOR BLOCKS OF FINITE GROUPS

    Mathematics Websites

    Pakianathan, Jonathan

    Science Foundation Grant #DMS-9970119 and National Security Agency Grant #MDA904-01-1-0067. 1 #12 to the following question: Date: February 22, 2002. Research of the second author supported in part by National suggest a strategy for handling a larger class of examples. In §4, we give some related results in case P

  13. Proceedings of the OOPSLA-93 Conference Workshop on Security for Object-Oriented Systems, Washington DC, September 26, 1993

    Computer Technologies and Information Sciences Websites

    Sandhu, Ravi

    by a grant from the National Security Agency, contract No: MDA904-92-C-5140. We are grateful to Pete SellProceedings of the OOPSLA-93 Conference Workshop on Security for Object-Oriented Systems-assurance Write-up in Multilevel Object-based Computing Roshan K. Thomas and Ravi S. Sandhu1 Center for Secure

  14. Irish Potatoes: Results of Experiments at Troupe Sub-station, Smith County. 

    Texas A&M University - TxSpace

    Green, Edward C.

    1904-01-01

    contamination of stainless steel by iron-55. Detecting iron-55 in Z-machine components presents a particular problem due to its low-abundance and the low-energy (5.9 keV) xray it emits. The nuclide is often below the minimum detectable activity (MDA) threshold...

  15. SEI 06 Towards a multi-tier sensor array for instrumenting large buildings SEI 06.1 Overview

    Computer Technologies and Information Sciences Websites

    Soatto, Stefano

    requirements. To collect comprehensive data for SHM domain experts, high-resolution vibration sensors on the bridge, and the sensor network acquired vibration samples continuously from each sensor for 24 hours. However, a few shortcomings were highlighted; the MDA-400 vibration card with 16-bit ADC that was used

  16. Supplemental Information for "Effect of Relative Humidity on SOA Formation from Isoprene/NO Photooxidation: Enhancement of 2-

    Geosciences Websites

    Meskhidze, Nicholas

    and Engineering, Gillings School of Global Public Health, the University of North Carolina, Chapel Hill, NC 27599 in the presence of neutral ammonium sulfate seed aerosol. For simplicity, only one structural isomer is shown. All) Measured Mass TOFMS Suggested Ion Formula Calculated Mass Difference (mDa) 119.0337 C4H7O4 ­ 119.0350 -1

  17. Training Tree Transducers Jonathan Graehl

    Computer Technologies and Information Sciences Websites

    transliteration. However, language problems like machine transla- tion break this mold, because they involve, 2003; Eisner, 2003), but also for This work was supported by DARPA contract F49620-00- 1-0337 and ARDA contract MDA904-02-C-0450. summarization (Knight and Marcu, 2002), paraphras- ing (Pang, Knight, and Marcu

  18. An asymptotically tight bound on the number of connected ...

    Hopf Topology Archive

    2009-07-14

    Supported in part by NSA grant MDA904-01-1-0057 and NSF grants ...... Jir? Matoušek, Lectures on discrete geometry, Graduate Texts in Mathematics, vol. ... School of Mathematics, Georgia Institute of Technology, Atlanta, GA 30332, U.S.A..

  19. The Role of Switching in Reducing the Number of Electronic Ports in WDM Networks

    Engineering Websites

    Berry, Randall

    ; The work of E. Modiano is sponsored by DARPA under contract number MDA972-02-1-0021 and by NSF under grants1 The Role of Switching in Reducing the Number of Electronic Ports in WDM Networks Randall A. Berry and Eytan Modiano Abstract-- We consider the role of switching in minimizing the number of electronic ports

  20. Note to readers: The PDF that is available on the PLoS website corrupted two of the symbols in the original

    Biotechnology Websites

    Nelson, Celeste M.

    & Celeste M. Nelson #12;Modulation of Invasive Phenotype by Interstitial Pressure-Driven Convection of Chemical and Biological Engineering and Department of Molecular Biology, Princeton University, Princeton on the invasive phenotype of patterned three-dimensional (3D) aggregates of MDA-MB-231 human breast cancer cells

  1. Lab on a Chip Cite this: DOI: 10.1039/c4lc01179a

    Materials Science Websites

    Bashir, Rashid

    to establish the relationship between mechanics and biological function. In the case of cancer, mechanical force microscopy (AFM). We measured the mass and stiffness of individual benign (MCF-10A), non-invasive malignant (MCF-7), and highly-invasive malignant (MDA-MB-231) breast cancer cells using the silicon resonant

  2. APPENDIX S1 Description and implementation of the models In this study, the eight SDMs were implemented to a great extent part as described in

    Environmental Sciences and Ecology Websites

    Grenouillet, Gael

    (regression methods), ANN, GBM, RF (machine learning methods), CTA, and MDA (classification methods). Model - Generalised Linear Models (library MASS) GLM is a flexible generalisation of classical linear regression into smooth curves by local fitting to subsections of the data (Hastie & Tibshirani, 1990). GAMs were fitted

  3. Transcranial direct current stimulation: State of the art 2008

    Biology and Medicine Websites

    Miall, Chris

    Transcranial direct current stimulation: State of the art 2008 Michael A. Nitsche, MDa , Leonardo G. Beyond this, transcranial direct current stimulation (tDCS) of different cortical areas has been shown direct currents is a promising tool in human neuroscience and neurobehavioral research. To facilitate

  4. NATURE MATERIALS | VOL 12 | APRIL 2013 | www.nature.com/naturematerials 287 news & views

    Physics Websites

    O'Hern, Corey S.

    dots identi ed the location of the targeting agent, and subsequently the cell receptors. Hyeon and co on MDA-MB-435 tumour cells in culture, and further show the targeting of 3 receptors on tumour vascular cells in a xenogra mouse model by a surface- immobilized RGD peptide. ese quantum dots are less toxic

  5. Local History

    University of Cambridge - Dspace

    Zla ba sgrol ma

    2009-11-17

    details on local history. Genre or type (i.e. epic, song, ritual) Interview Name of recorder (if different from collector) Zla ba sgrol ma Date of recording November 17th 2009. Place of recording Dzong sar Monastery, Mda' ma Township, Sde dge...

  6. Abordagem XIS ao Desenvolvimento de Sistemas de Informao Alberto Rodrigues da Silva

    Computer Technologies and Information Sciences Websites

    da Silva, Alberto Rodrigues

    , designadamente: segue uma abordagem baseada na especificação de modelos; centrada em arquitecturas de software; e interactivos, MDA, modelos em UML e XML, geração automática, arquitecturas de software 1 Introdução responsáveis por providenciar arquitecturas elegantes, flexíveis e reutilizáveis. A ideia subjacente ao

  7. Essentials of the 3rd UML Workshop in Software Model Engineering (WiSME'2004)

    Computer Technologies and Information Sciences Websites

    Gogolla, Martin - Fachbereich 3

    Essentials of the 3rd UML Workshop in Software Model Engineering (WiSME'2004) Martin Gogolla (A/SOAP). This approach is intended to play a key role in the #12;elds of information system and software engineering. MDA Development (MDD). This aims to make models the primary driving assets in all aspects of software development

  8. Insights into microtubule nucleation from the crystal structure of human g-tubulin

    Biology and Medicine Websites

    Stearns, Tim

    Insights into microtubule nucleation from the crystal structure of human g-tubulin Hector Aldaz1 *, Luke M. Rice1 *, Tim Stearns2 & David A. Agard1 Microtubules are hollow polymers of ab-tubulin. Initiation of new microtubules in vivo requires g-tubulin, organized as an oligomer within the 2.2-MDa g-tubulin

  9. Introduction The higher order chromatin structure is an important regulatory

    Biology and Medicine Websites

    Rippe, Karsten

    microinjection of dextrans from 42 kDa to 2.5 MDa molecular mass labeled with fluorescein isothiocyanate (FITC-dextrans accessibility of chromatin directly from the nuclear distribution of fluorescent dextrans with different sizes. In previous studies, a mostly unlimited nuclear access has been reported for a dextran size of 77 k

  10. Recognizing Dysarthric Speech due to Amyotrophic Lateral Sclerosis with Across-Speaker Articulatory Normalization

    Computer Technologies and Information Sciences Websites

    , United States 3 MDA/ALS Center, Texas Neurology, Dallas, Texas, United States {seongjun.hahm, wangjun the phoneme error rates (PERs) using any or combined normalization approaches. DNN-HMM outperformed GMM neuron disease that causes the death of both up- per and lower motor neurons [9]. The cause

  11. Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy

    Chemistry Websites

    Brolo, Alexandre G.

    Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman145, PC3 and LNCaP), breast (MDA-MB-231 and MCF7) and lung (H460), were irradiated in vitro

  12. Minimization of thermodynamic costs in cancer cell invasion

    Mathematics Websites

    Sontag, Eduardo

    Minimization of thermodynamic costs in cancer cell invasion Liyu Liua,1 , Guillaume Duclosb,1 , Bo aspect of cancer, occurs when metastatic cancer cells in a tumor break through the basement membrane and penetrate the extracellular matrix. We show that MDA-MB-231 metastatic breast cancer cells cooperatively

  13. http://rsc.li/frontiers-organic F R O N T I E R S

    Chemistry Websites

    Theodorakis, Emmanuel

    cancer metastasis by tar- geting critical regulators of extracellular matrix, cell motility and adhesion metabolites were found to inhibit acinar morphogenesis in MDA-MB-231 cells, a highly metastatic breast cancer.li/frontiers-organic Fusarisetins: structure­function studies on a novel class of cell migration inhibitors Eduardo J. E. Caro

  14. Fusarisetin A: scalable total synthesis and related studies Eduardo J. E. Caro-Diaz,a

    Chemistry Websites

    Theodorakis, Emmanuel

    in MDA-MB-231 cells, a particularly aggressive breast cancer cell line. Specifically, 1 was found that displays an unprecedented chemical motif and remarkable bioactivities as a potent cancer migration that this compound is able to inhibit different types of cell migration. Moreover, the C5 epimer of (+)-1 was also

  15. Anti-inflammatory Properties of Citrus Limonoids and Their Isolation and Characterization 

    Texas A&M University - TxSpace

    Kim, Jin Hee

    2012-02-14

    were screened for their cytotoxicity on estrogen receptor (ER)-positive (MCF-7) or ER-negative (MDA-MB-231) human breast cancer cells. The MCF-7 cell was more susceptible to tested limonoids. Although most of limonoids induced anti-aromatase activity...

  16. Inhibition of invasive breast cancer cell growth by selected peach and plum phenolic antioxidants 

    Texas A&M University - TxSpace

    Vizzotto, Marcia

    2006-04-12

    -flesh genotypes; however, it was strongly correlated only with the phenolic content in light-colored flesh plums. Extracts from selected genotypes of peaches and plums and their fractions were evaluated against two breast cancer cell lines (MDA-MB-435 and MCF-7...

  17. Inhibition of breast and prostate cancer cell growth by 3,3'-diindolylmethane and related compounds 

    Texas A&M University - TxSpace

    Kotha, Leela

    2009-05-15

    with selective aryl hydrocarbon receptor modulators (SAhRMs), such as diindolylmetane/(DIM), 2,3,7,8-tetrachlorodibenzo-pdioxin/( TCDD), and 6-6-methyl-1,3,8-trichlorodibenzofuran/(MCDF) that exhibit antiproliferative activity in several cancer cell lines. MDA...

  18. E cient Routing and Scheduling Algorithms for Optical Networks

    Computer Technologies and Information Sciences Websites

    Sudan, Madhu

    No. MDA 972-92-C-0084 from ARPA. #12;1. Introduction Fiber-optic networking technology usingE cient Routing and Scheduling Algorithms for Optical Networks Alok Aggarwal Amotz Bar-Noy Don transmissions in optical networks. In optical networks, the vast bandwidth available in an optical ber

  19. Gray Code Enumeration of Families of Integer Partitions David Rasmussen \\Lambda

    Computer Technologies and Information Sciences Websites

    Savage, Carla D.

    Gray Code Enumeration of Families of Integer Partitions David Rasmussen \\Lambda Carla D. Savage y Research supported National Security Agency Grant No. MDA904­90­H­4011. 1 #12; Proposed Running Head: Gray change, or Gray code, order. In particular, we construct Gray code listings for the classes P ffi (n; k

  20. Glomus tumors in individuals with neurofibromatosis type 1

    Biology and Medicine Websites

    Kornfeld, S. Kerry

    suppressor gene (OMIM 613113); tumors form after somatic inactivation of the 1 remaining functional NF1Glomus tumors in individuals with neurofibromatosis type 1 Monique G. Kumar, MPhil, MD,a Ryan J: Glomus tumors have recently been reported in individuals with the neurofibromatosis type 1 (NF1) cancer

  1. Understanding Collective Crowd Behaviors: Learning a Mixture Model of Dynamic Pedestrian-Agents

    Engineering Websites

    Wang, Xiaogang

    Understanding Collective Crowd Behaviors: Learning a Mixture Model of Dynamic Pedestrian@ee.cuhk.edu.hk, xtang@ie.cuhk.edu.hk Abstract In this paper, a new Mixture model of Dynamic pedestrian-Agents (MDA) is proposed to learn the collective behavior patterns of pedestrians in crowded scenes. Col- lective behaviors

  2. Int J Comput Vis DOI 10.1007/s11263-014-0735-3

    Computer Technologies and Information Sciences Websites

    Wang, Xiaogang

    Pedestrian-Agents Bolei Zhou · Xiaoou Tang · Xiaogang Wang Received: 9 September 2013 / Accepted: 24 May 2014 fields such as statistical physics and biology. In this paper, a new mixture model of dynamic pedestrian-Agents (MDA) is proposed to learn the collec- tive behavior patterns of pedestrians in crowded scenes from

  3. Nanoliter Reactors Improve Multiple Displacement Amplification

    Engineering Websites

    Quake, Stephen R.

    of Bioengineering, Stanford University, Stanford, California, United States of America, 2 Howard Hughes Medical culture, there is great interest in genomic sequencing directly from single cells. Sufficient DNA Escherichia coli and amplify genomic DNA by MDA in 60-nl reactions. Our results confirm a report that reduced

  4. RESEARCH ARTICLE Open Access Selective gene-expression profiling of migratory

    Biology and Medicine Websites

    Kenny, Paraic

    predicts clinical outcome in breast cancer patients Antonia Patsialou1* , Yarong Wang1 , Juan Lin2: Metastasis of breast cancer is the main cause of death in patients. Previous genome-wide studies have this assay in orthotopic xenografts of human MDA- MB-231 breast cancer cells to isolate selectively

  5. The relationship between follicle development and progesterone

    Biology and Medicine Websites

    Terasaki, Mark

    expression in women undergoing in vitro fertilization Alyaa Elassar, M.D.,a Xiufang Liu,b Victoria Scranton ovarian hyperstimulation (COH). Setting: Fertility center/basic science laboratory. Patient(s): Eighty of follicles develop to allow for ET and subsequent pregnancy. (Fertil SterilÒ 2012;97:572­8. Ó2012 by American

  6. The molecular architecture of the nuclear pore complex

    Biotechnology Websites

    Sali, Andrej

    transport. Each NPC spans the nuclear envelope through a pore formed by the fusion of the inner and outerARTICLES The molecular architecture of the nuclear pore complex Frank Alber1 *, Svetlana Nuclear pore complexes (NPCs) are proteinaceous assemblies of approximately 50 MDa that selectively

  7. Math. Res. Lett. 13 (2006), no. 00, 10001100NN c International Press 2007 REFLECTION GROUPS AND DIFFERENTIAL FORMS

    Mathematics Websites

    Shepler, Anne

    2006-01-01

    AND DIFFERENTIAL FORMS Julia Hartmann and Anne V. Shepler Abstract. We study differential forms invariant under and National Security Agency grant MDA904-03-1-0005. 10001 #12;10002 Julia Hartmann and Anne V. Shepler the set of forms (see Section 6 for an example). Hartmann [8] showed that Solomon's theorem holds for groups

  8. Daniel B. Kirk-Davidoff http://www.atmos.umd.edu/~dankd

    Environmental Sciences and Ecology Websites

    Kirk-Davidoff, Daniel

    Information Systems LLC 9501 Good Lion Rd. 820 West Diamond Ave. Suite 300 Columbia, MD 21045 Gaithersburg, MD ERICA field experiment. Employment MDA Information Systems LLC February 2010 -- Present Chief Scientist, Climate and Weather Services Developed and brought to market wind power forecasting for all North American

  9. November 2007 Regional Newsletter CALENDAR OF EVENTS

    Renewable Energy Websites

    sessions and workshops on Thursday that include organic production, certification, and marketing, farm Program NMC Oleson Center, 8:30-4:30 12/4-6 Great Lakes EXPO Fruit, Vegetable, and Farm Market Grand Rapids 12/7-8 Farm it Forward Frankenmuth, MI 12/10 Pesticide Recertification Review & MDA Test Banks

  10. Robot Skill Learning Through Intelligent Experimentation

    Computer Technologies and Information Sciences Websites

    Schneider, Jeff

    number MDA972­92­J­1012, NSF research grant number IRI­9306454, U.S. Air Force research grant number performance by making use of information gained on previous trials. On the problem of learning to throw a ball for long throws. Most closed loop learners improve their performance by gradient descent on a cost function

  11. Whole genome amplification of the rust Puccinia striiformis f. sp. tritici from single spores

    Renewable Energy Websites

    Hsiang, Tom

    2009 Keywords: -tubulin gene Multiple displacement amplification rDNA-ITS Single-spore Whole genome for DNA extractions. Multiple displacement amplification (MDA) was demonstrated in this study for whole genome amplification from single spores of the rust fungus, Puccinia striiformis. The genomic DNA

  12. Detection of Covalent and Noncovalent Intermediates in the Polymerization Reaction Catalyzed by a C149S Class III Polyhydroxybutyrate Synthase

    MIT - DSpace

    Li, Ping

    Polyhydroxybutyrate (PHB) synthases catalyze the conversion of 3-hydroxybutyryl coenzyme A (HBCoA) to PHB with a molecular mass of 1.5 MDa. The class III synthase from Allochromatium vinosum is a tetramer of PhaEPhaC (each ...

  13. Engineering microscale cellular niches for three-dimensional multicellular co-cultures

    Materials Science Websites

    Kim, Ho-Young

    play important roles in tissue engineering, tumor growth and metastasis, and in defining stem cell by culturing MDA-MB-231 metastatic breast cancer cells and RAW 264.1 macrophage cells within distinct collagen efforts in the fields of tissue engineering and cancer, there is an increased emphasis to move cell

  14. Analyzing Communication Latency using the Nectar Communication Processor

    Computer Technologies and Information Sciences Websites

    Steenkiste, Peter

    , but that can also execute application code. This architecture allows us to analyze message latency both between by the Defense Advanced Research Projects Agency (DOD) monitored by DARPA/CMO under Contract MDA972­90­C­0035. 1, or should be, of the order of 10s of microseconds [7], and does not account for the order of magnitude

  15. Measurement Limits to $^{134}$Cs Concentration in Soil

    CERN Preprints

    Ahn, J K; Lee, H M; Kim, T H; Park, J N; Kang, Y S; Lee, H S; Kim, S J; Park, J Y; Ryu, S Y; Kim, H Ch; Kang, W G; Kim, S K

    2009-01-01

    We investigate the caesium concentrations in soils in mountain areas near Gori nuclear power plant in Korea, focusing on the measurement limits to the $^{134}\\mathrm{Cs}$. In order to lower the minimum detectable amount (MDA) of activity for the $134}\\mathrm{Cs}$, we have used the ammonium molybdophosphase (AMP) precipitation method to get rid of the $^{40}$K existing in natural radioactivity, which reduces the MDA of activity about ten times smaller than those without the AMP precipitation method. The MDA results for the $^{134}\\mathrm{Cs}$ were found to be in the range between 0.015 and 0.044 Bq/kg-dry weight. In order to diminish the background, we also have measured a part of the soil samples in Yangyang, a small town in the east coast of Korea. However, it turns out that in order to detect the $^{134}\\mathrm{Cs}$ in the samples the MDA should be reduced to the level of mBq/kg-dry weight.

  16. S.-g. Lee et al. (Eds.): DASFAA 2012, Part I, LNCS 7238, pp. 6378, 2012. Springer-Verlag Berlin Heidelberg 2012

    Computer Technologies and Information Sciences Websites

    Liu, Chengfei

    business data and their evolution through business processes, but also allows business and IT stakeholders of automation and collaboration. Promisingly, Service-Oriented Architecture (SOA) shows itself as technology principle and model-driven architecture (MDA) design concept [1, 3, 5, 7, 12]. This approach has been

  17. Tentative topics for oral examination "Introduc-tion to Extreme Value Theory", January 23 and

    Mathematics Websites

    Mikosch, Thomas

    (Theorem 3.4.5, equivalence between (a) and (b)) result in the case MDA(). 5. Order statistics The distribution of one order statistic. The joint density of the ordered sample. The joint density of k upper order statistics. (Propo- sition 4.1.2) The representation of the order statistics of an iid uniform

  18. Energetics of Electron Transfer Reactions Dmitry Matyushov

    Chemistry Websites

    Matyushov, Dmitry

    Energetics of Electron Transfer Reactions Dmitry Matyushov Arizona State University MIT, November-Hush Theory of Electron Transfer Two-parameters model: Fact = ( + F0)2 4 is the reorganization energy F0 of "polarizabil- ity": · D-A coupling through mDA · Coupling of D and A states to other electronic states mDk m

  19. Control Transfer in Operating System Kernels Richard P. Draves

    Computer Technologies and Information Sciences Websites

    of Computer Science Carnegie Mellon University Pittsburgh, PA 15213 Submitted in partial fulfillment the title "Research on Parallel Computing," ARPA Order No. 7330, issued by DARPA/CMO under Contract MDA972 gave me invaluable guidance in my first years at CMU. The Mach project brought together a great group

  20. Estimation of iron-55 volumetric contamination via surrogates produced during Z-machine operations 

    Texas A&M University - TxSpace

    Flores-McLaughlin, John

    2009-05-15

    to the National Science Foundation Bridge to the Doctorate program which provided the primary funding and scholarly discussions towards this academic pursuit. vi NOMENCLATURE MDA Minimum Detectable Activity Fe Iron Cr Chromium Co Cobalt............................................................................................................................. 34 viii LIST OF FIGURES FIGURE Page 1 Cr-50 (n, ?) Cr-51 and Fe-54 (n, ?) Fe-55 probability vs. incident neutron...

  1. Mechanistic Insight with HBCH[subscript 2]CoA as a Probe to Polyhydroxybutyrate (PHB) Synthases

    MIT - DSpace

    Zhang, Wei

    Polyhydroxybutyrate (PHB) synthases catalyze the polymerization of 3-(R)-hydroxybutyrate coenzyme A (HBCoA) to produce polyoxoesters of 1–2 MDa. A substrate analogue HBCH[subscript 2]CoA, in which the S in HBCoA is replaced ...

  2. Rhizomatous plant Preparation

    Biology and Medicine Websites

    Trask, Barbara Crippes

    of curcumin 95 act as an anti-tumorogenic agent against MDA-MB- 231 breast cancer cells on nude mice (nu/nu Mus musculus)? #12;Athymic nude mice: 12 6 control 6 experimental Autoclave Peanut butter balls BID damage Test for GST gene in nude mice #12;OUR funding at WSU Dr. Chung for assisting with the histology

  3. julio-septiembre2006Cinvestav58 La Pennsula de Yucatn est siendo sometida a

    Mathematics Websites

    en el Departamento de Recursos del Mar. lcapurro@mda.cinvestav.mx Vocación turística de la Península EVOLUTION OF THE WESTERN LITTORAL OF THE YUCATAN PENINSULA ­ EROSION AND WATER QUALITY 2000-2006". Luis61 de acuíferos cavernosos en comunicación directa con el agua de mar, lo que hace que con vientos

  4. SoSyM manuscript No. (will be inserted by the editor)

    Computer Technologies and Information Sciences Websites

    Bordbar, Behzad

    UML to Alloy Kyriakos Anastasakis1 , Behzad Bordbar1 , Geri Georg2 , Indrakshi Ray2 1 School be automatically transformed into Alloy which, in turn, can be automatically analysed by the Alloy Analyzer. The proposed approach relies on MDA techniques to transform UML models to Alloy. This paper reports

  5. SoSyM manuscript No. (will be inserted by the editor)

    Computer Technologies and Information Sciences Websites

    Ray, Indrakshi

    UML to Alloy Kyriakos Anastasakis1 , Behzad Bordbar1 , Geri Georg2 , Indrakshi Ray2 1 School. Specifically, we show how UML models can be automatically transformed into Alloy which, in turn, can be automatically analysed by the Alloy Ana- lyzer. The proposed approach relies on MDA techniques to transform UML

  6. UF takes home first place in three categories at the second annual Florida Statewide Graduate Student Research Symposium

    Mathematics Websites

    Sin, Peter

    , including arts and humanities, biological sciences, education, engineering, health sciences, life sciences Knockdown of Lactate Dehydrogenase A in MDA-MB231 Cells Does Not Decrease Lactic Acid Production" Second Involved in Grape Disease Tolerance" Education First Place ­ Shainna Ali, University of Central Florida

  7. ARTICLE doi:10.1038/nature13015 Mechanism of Tc toxin action revealed in

    Biology and Medicine Websites

    Just, Armin

    into the host4,5 . This damages and ultimately kills the target cells. Tcs with specificity for insects weight of 1.41 MDa--at a resolution of 4.0 A° (Fig. 1a and Supplementary Video 1). The TcA protomer

  8. This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the

    Biology and Medicine Websites

    Fülöp, Vilmos

    Characterisation of the Insecticidal Toxin XptA1, Reveals a 1.15 MDa Tetramer with a Cage-like Structure Sarah C of one of the toxin components, XptA1, from Xenorhabdus nematophila PMFI296 to a resolution of 23 Å. Membrane binding studies indicate that the three- component toxin system has a different mode of action

  9. Research Article Accumulation of microvascular target organ damage

    Computer Technologies and Information Sciences Websites

    Zabulis, Xenophon

    , and Stella Douma, MDa a 3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University, Aristotle University of Thessaloniki, Thessaloniki, Greece; c Institute of Computer Science, Foundation, Research Fellow of Aristotle University of Thessaloniki, Papa- georgiou Hospital, Ring Road Nea Eukarpia

  10. Modelling Knowledge and Game Based Learning: Model Driven Approach

    Computer Technologies and Information Sciences Websites

    in university education. Important issue that requires attention is proper integration of knowledge in to game is knowledge modelling in educational games. In our work we proposed a Model Driven Approach (MDA) to educational game development that focuses on models rather than on implementation. This provides many

  11. Modelling Knowledge and Game Based Learning: Model Driven Approach

    Computer Technologies and Information Sciences Websites

    of using games in university education. Important issue that requires attention is proper integration topic of this paper is knowledge modelling in educational games. In our work we proposed a Model Driven Approach (MDA) to educational game development that focuses on models rather than on implementation

  12. SPECIALISSUE DISTRIBUTED SYSTEMS

    Computer Technologies and Information Sciences Websites

    Newhall, Tia

    control? This processing occurs in a fraction of a second, using natural processing elements was supported by the Defense Advanced Research Projects Agency of the Department of Defense under Contract MDA, preprocessing, and accessing data. On-line transaction processing is an application that may contain a local

  13. Building Songs 7

    University of Cambridge - Dspace

    Zla ba sgrol ma

    2009-10-28

    Date of recording October 28th 2009. Place of recording DzaM mda' Village, Phu ma Township, Sde dge County, Dkar mdzes Tibetan Autonomous Prefecture, Sichuan Province, China. Name(s), age, sex, place of birth of performer(s) Skar ma chos mdzin...

  14. A Decentralized Broker Architecture for Collaborative Business Process Modelling and Enactment

    Computer Technologies and Information Sciences Websites

    Bauer, Bernhard

    ], we have extended the MDA para- digm to fit the needs of modelling Cross-Enterprise Business Processes in a cross-enterprise relationship, i.e., corresponding to a star topology of a business relationship business relationships, focusing on scenarios supporting collaboration between Small and Medium Enterprises

  15. Localization of Unconventional Myosins V and VI in Neuronal Growth Cones

    Biology and Medicine Websites

    Lin, Chi-Hung

    -Ming University, Taipei, Taiwan Contract grant sponsor: MDA (M.S.M.). Contract grant sponsor: National Institutes of Health; contract grant number: DK-25387 and PPG 1-P01-DK55389-01 (M.S.M.) and NS-28695 (P.F.). © 2000

  16. Final Report on Research in Parallel Computing: Networkbased Multicomputers

    Computer Technologies and Information Sciences Websites

    1995 Carnegie Mellon University Computer Science Department Abstract No existing parallel architecture, and monitored by the Space and Naval Warfare Systems Command under contract MDA972­90­C­0035. Views architectures, such as SIMD machines, MIMD machines, vector processors, machines with a common (globally

  17. PERIODIC WAVELET TRANSFORMS AND PERIODICITY JOHN J. BENEDETTO AND G

    Mathematics Websites

    Benedetto, John J.

    of the observed time-series [6]. In the process, electrocorticogram (ECoG) data was used instead of the more common electroencephalogram (EEG) data. To obtain ECoG data, electrodes are planted directly, College Park, MD 20742-4015, USA, E- mail: jjb@math.umd.edu. Supported from DARPA Grant MDA-972011003

  18. UNSUPERVISED MULTIBAND IMAGE SEGMENTATION USING HIDDEN MARKOV QUADTREE AND COPULAS

    Computer Technologies and Information Sciences Websites

    by the French government (ACI- MDA project: Masses de Donnes en Astronomie http://cdsweb.u- strasbg, requiring mul- tivariate probability density computations for the data like- lihood term, is often density on Markov Quadtree. 1. INTRODUCTION Multiband image segmentation is a very useful tool in several

  19. Understanding Collective Crowd Behaviors: Learning a Mixture Model of Dynamic Pedestrian-Agents

    Computer Technologies and Information Sciences Websites

    Huang, Jianwei

    green lines) as well as the future behaviors (indicated as dashed green lines). The shared beliefs and dynamics of movements gen- erate several dominant collective dynamic patterns in the scene. B) MDA learns might not acquaint with each other, their shared movements and destinations make them coordinate

  20. SOCIAL MEASURES MONITORING SYSTEM Overview and Metadata Sheets

    Environmental Sciences and Ecology Websites

    .D., Department of Forest Resources College of Food, Agricultural and Natural Resource Sciences University use at this time. Beginning in 2014, agencies are piloting the SMMS in projects to develop program member organizations. The SMMS development project was funded by MDA, MPCA, DNR, MDH and BWSR. Results

  1. Wireless crack measurement for control of construction vibrations Charles H. Dowding1

    Engineering Websites

    attached sensor board is mounted a few inches away from the sensor. Though only one "sensor node number of "sensor nodes." As shown by the inserted pictures of Figure 1, each sensor node consists of one Mica2 mote logger radio module (low left thumbnail), one MDA300 sensor board (low middle thumbnail

  2. A comparative study of nano-scale coatings on gold electrodes for bioimpedance studies of breast cancer cells

    Physics Websites

    Heflin, Randy

    - sitivity to MDA-MB-231 metastatic breast cancer cells. There was also a significant shift in the peak roughness . Bioimpedance . ECIS . Breast cancer 1 Introduction Bioimpedance is the complex electricalA comparative study of nano-scale coatings on gold electrodes for bioimpedance studies of breast

  3. Domain analysis for estrogen receptor/Sp1-mediated transactivation and detection of estrogen receptor/Sp1 protein interactions in living cells 

    Texas A&M University - TxSpace

    Kim, KyoungHyun

    2005-11-01

    of ER? on activation of ER?/Sp1. 17Beta-estradiol (E2) and the antiestrogens 4-hydroxytamoxifen and ICI 182,780 induced reporter gene activity in MCF-7 and MDA-MB-231 cells cotransfected with human or mouse ER? (hER? or MOR), but not ER? and GC...

  4. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Nov. 2011, p. 76637668 Vol. 77, No. 21 0099-2240/11/$12.00 doi:10.1128/AEM.00289-11

    Biology and Medicine Websites

    Bae, Jin-Woo

    amplified shotgun library (LASL) and multiple displacement amplification (MDA) methods, were applied filtration and amplified by these two methods. 454 pyrosequencing was used to read the metagenomic sequences libraries or 454 pyrose- quencing. Thus, viral DNA must be amplified for most meta- genomic studies (2­8, 10

  5. Evaluating ecological tradeoffs in fisheries management: a study case for the yellowfin tuna fishery in the Eastern Pacific Ocean

    Environmental Sciences and Ecology Websites

    Enríquez Andrade, Roberto Ramón

    in the selection of alternative policy options. An important class of techniques within MDA is vector optimization perspective, vector optimization models are particularly suited for situations when the decision rule requires each objective to be kept as high (or low) as possible. Solving vector optimization problems usually

  6. Computer Science at Kent Model Transformations in YATL.

    Computer Technologies and Information Sciences Websites

    Kent, University of

    ;Chapter 1. TRANSFORMATION ENVIRONMENT The OMG's MDA is a new approach to develop large software systems editor (e.g. Rational Rose or Poseidon) · KMF-Studio is used to generate Java implementations of the source and target models. · The source model repository is populated used either Java hand-written code

  7. Clustering, Community Partition and Disjoint Spanning Trees

    Mathematics Websites

    Zhang, Cun-Quan "CQ"

    by a grant of the National Security Agency (MDA904-01-1-0022) and a grant of WV EPSCoR. Y. Ou was supported. Clustering method is an important statistical tool for data mining [Anthonisse 1971; Berkhin 2002; Bezdek

  8. CTIT Technical Report TRCTIT0327, University of Twente Model Driven Architecture

    Computer Technologies and Information Sciences Websites

    Rensink, Arend

    consisting of 7 full papers and 7 short presentations. We have an invited presentation by Wim Bast (of Cumpu the QVT RfP, we hope for an interesting exchange of opinions on this subject. i #12;Invited Speaker · Wim of the journal special issue on MDA) · Uwe Assmann, University of Linkøping, Sweden · Wim Bast, Compuware

  9. The NMRRosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope

    Biotechnology Websites

    Baker, David

    12, 2014) Filamentous phage are elongated semiflexible ssDNA viruses that infect bacteria. The M13 that infect bacteria (1, 2). These large assemblies (15­35 MDa) contain a circular single-stranded (ss) DNA ge in a helical array surrounding a core of a circular ssDNA. The major coat proteins constitute 85% of the total

  10. Graphic and Protographic Lists of Integers Dmitry Fon-Der-Flaass

    Mathematics Websites

    West, Douglas B.

    upon work supported by NSA under Award No. MDA904-03-1-0037, which requires the disclaimer that any of the author(s) and do not necessarily reflect the views of the NSA. 1 #12;merger X Y is not graphic, where

  11. Graphic and Protographic Lists of Integers Dmitry Fon-Der-Flaass , Douglas B. West y

    Mathematics Websites

    West, Douglas B.

    @math.uiuc.edu. This material is based upon work supported by NSA under Award No. MDA904-03-1-0037, which requires are those of the author(s) and do not necessarily re ect the views of the NSA. 1 #12; merger X [ Y

  12. http://www.elsevier.com/locate/jctb Journal of Combinatorial Theory, Series B 90 (2004) 147159

    Mathematics Websites

    Kostochka, Alexandr V.

    2004-01-01

    supported by NSF Grant DMS-0099608 and by INTAS grant 97-1001. 3 Partially supported by NSA Grant MDA904 reflect the views of the NSF or NSA. 0095-8956/$ - see front matter r 2003 Elsevier Inc. All rights

  13. A Low-Exponential Algorithm for Counting Vertex Mark K. Goldberg, Thomas H. Spencer, David A. Berque

    Computer Technologies and Information Sciences Websites

    Goldberg, Mark

    Polytechnic Institute; the work of this author supported in part by the NSA under grant MDA904-90-H-4027 of Mathematics and Computer Science, DePauw University; the work of this author supported in part by the NSA

  14. Homomorphisms from sparse graphs with large girth

    Mathematics Websites

    West, Douglas B.

    -0099608 and by INTAS grant 97-1001. Partially supported by NSA grant MDA904-03-1-0037. The U.S. grants of the NSF or NSA. 1 #12;uv E(G); a graph having such a coloring is (k, d)-colorable. Note that a (k, 1

  15. Acta Mathematica Sinica, English Series Jan., 2006, Vol. 22, No. 1, pp. 1322

    Mathematics Websites

    Ravenel, Douglas

    = a for all a D. A (right) DGA-module M over D is a chain complex that is a (right) module over D and d(ma) = (dm)a + (-1)|m| m(da) for all m M and a D. Definition 1.1 Let V be a coalgebra and D a DGA

  16. DEPARTAMENTO DE FSICA APLICADA

    Mathematics Websites

    Ruiz Suárez. Investigador Titular y Jefe del Departamento. Doctor en Ciencias (1987) University complejos. cruiz@mda.cinvestav.mx Juan José Alvarado Gil. Investigador Titular. Doctor en Ciencias (1990 Antonio Azamar Barrios. Investigador Titular. Doctor en Ciencias (2000) UNAM. Temas de investigación

  17. DEPARTAMENTO DE FSICA APLICADA

    Mathematics Websites

    Ruiz Suárez. Investigador Titular y Jefe del Departamento. Doctor en Ciencias (1987) University complejos. cruiz@mda.cinvestav.mx Juan José Alvarado Gil. Investigador Titular. Doctor en Ciencias (1990 Barrios. Investigador Titular. Doctor en Ciencias (2000) UNAM. Temas de investigación: Química y física de

  18. A UML profile for multidimensional modeling in data warehouses

    Computer Technologies and Information Sciences Websites

    Song, Il-Yeol

    A UML profile for multidimensional modeling in data warehouses Sergio Luja´n-Mora a , Juan Trujillo Abstract The multidimensional (MD) modeling, which is the foundation of data warehouses (DWs), MD databases modeling for data warehouses. Moreover, our proposal is Model Driven Archi- tecture (MDA) compliant and we

  19. IR-Case Tool Joo Ferreira1, Alberto Silva2

    Computer Technologies and Information Sciences Websites

    da Silva, Alberto Rodrigues

    as model-to-model transformation templates in order to accelerate their system development tasks. This step-Case tool for the creation of IR (Information Retrieval) systems inspired on a set of best practices; it is based on generative programming techniques. This approach follows in essence the MDA (Model Driven

  20. 1.15?Å resolution structure of the proteasome-assembly chaperone Nas2 PDZ domain

    University of Kansas - KU ScholarWorks

    Singh, Chingakham R.; Lovell, Scott; Mehzabeen, Nurjahan; Chowdhury, Wasimul Q.; Geanes, Eric S.; Battaile, Kevin P.; Roelofs, Jeroen

    2014-04-01

    The 26S proteasome is a 2.5 MDa protease dedicated to the degradation of ubiquitinated proteins in eukaryotes. The assembly of this complex containing 66 polypeptides is assisted by at least nine proteasome-specific chaperones. One of these, Nas2...

  1. Machine Vision and Applications DOI 10.1007/s00138-007-0085-z

    Computer Technologies and Information Sciences Websites

    Terzopoulos, Demetri

    Robotics, Ltd.(currently MDA Space Missions), a Cana- dian company that has supported human space flight since the early 1980s through advanced robotic systems, such as the Space Shuttle's Canadarm and control for space robotics Autonomous Satellite Rendezvous and Docking Faisal Qureshi · Demetri

  2. Geophysical Fluid Dynamics Laboratory Review

    Environmental Sciences and Ecology Websites

    air quality and climate via methane emission controls: A viable option? North America Ozone reduction where surface ozone (MDA8) > 70 ppbv CLIMATE AIR QUALITY 2) pp BASE 2005 BASE 2030 CH4 OZONE METHANE (W of Future Changes in Climate on Air Quality 20year AM3 simulations with annuallyinvariant emissions of ozone

  3. Optical characterization of a dual-frequency hybrid aligned nematic liquid crystal cell

    Physics Websites

    Jewell, Sharon

    Optical characterization of a dual-frequency hybrid aligned nematic liquid crystal cell S. A dispersive dual-frequency nematic liquid crystal (MDA-00-3969 (Merck KGa)) has been determined using to be determined using a multi-layer optics model in combination with a liquid crystal free-energy minimization

  4. Ricinus communis (Cultivated) 6 

    Texas A&M University - TxSpace

    James R. Manhart

    2011-08-10

    anthocyanins. Fraction III (flavonols) and Fraction IV (polymerized compounds) had no effect on the cell lines. Phenolic acids present in fraction I induced apoptosis in MDA-MB-435 estrogen receptor-negative cell line. Fraction I did not induced apoptosis...

  5. Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex

    Biotechnology Websites

    Sali, Andrej

    -related heptameric module from the nuclear pore complex Yi Shi1 *, Javier Fernandez-Martinez2 *, Elina Tjioe3-(3-dimethylaminopropyl) carbodiimide NPC: nuclear pore complex EM: electron microscopy Nup: nucleoporin VCC: vesicle assembly (~600 kDa), sixteen copies of which form the outer rings of the 50 MDa nuclear pore complex (NPC

  6. Fat Points, Inverse Systems, and Piecewise Polynomial Anthony V. Geramita

    Mathematics Websites

    Schenck, Hal

    Fat Points, Inverse Systems, and Piecewise Polynomial Functions Anthony V. Geramita and Hal Schenck Abstract We explore the connection between ideals of fat points (which correspond to sub- schemes of Pn Partially supported by the National Security Agency through grant MDA 904-95-H-1035 1 #12;Fat Points

  7. September 18, 2012 Seattle, Washington

    Engineering Websites

    for Characterization of Existing Asphalt Pavement Prior to Concrete Overlays ­ Dale Harrington, National CP Tech Center · CP Road Map Future Direction ­ Tom Cackler, National CP Tech Center · RCC Applications Update ­ Dale Harrington, National CP Tech Center · Mix Design and Analysis (MDA): Air Void Research ­ Tyler Ley, Oklahoma

  8. A new approach of designing Multi-Agent Systems

    CERN Preprints

    Maalal, Sara

    2012-01-01

    Agent technology is a software paradigm that permits to implement large and complex distributed applications. In order to assist analyzing, conception and development or implementation phases of multi-agent systems, we've tried to present a practical application of a generic and scalable method of a MAS with a component-oriented architecture and agent-based approach that allows MDA to generate source code from a given model. We've designed on AUML the class diagrams as a class meta-model of different agents of a MAS. Then we generated the source code of the models developed using an open source tool called AndroMDA. This agent-based and evolutive approach enhances the modularity and genericity developments and promotes their reusability in future developments. This property distinguishes our design methodology of existing methodologies in that it is constrained by any particular agent-based model while providing a library of generic models

  9. POSTING TEMPLATE Urgent Opportunity: French Canadian Native Speaker

    Environmental Sciences and Ecology Websites

    Northern British Columbia, University of

    application au lien suivant : https://erec.appen.com/sap/bc/webdynpro/sap/hrrcf_a_posting_apply?param=cG9zdF9pbnN0X2d1aW Q9MDA1MDU2ODA3Qjk5MUVFNTlERDkyQTdCMzBFQzkxNTcmY2FuZF90eXBlPUVYVA%3d%3d&sap- client=300

  10. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

    Biology and Medicine Websites

    Sabatini, David M.

    : sabatini@wi.mit.edu Nature Genetics: doi:10.1038/ng.2471 #12;cleaved CASPASE3 RPS6 Clone B Clone A W CloneA WT KBM7 Time(min) Nature Genetics: doi:10.1038/ng.2471 #12;KBM7 MDA-MB-468 GAPDH Raptor shRNA: G Institute of Technology (MIT), Cambridge, MA 02139, USA. 3 Broad Institute, Seven Cambridge Center

  11. [Type text] [Type text] S1 Efficient NQO1 Substrates are Potent and Selective

    Chemistry Websites

    Hergenrother, Paul J.

    expression and activity in cell lines utilized in the paper. A) the non-small cell lung cancer cell line A549 and A549 cells which were pre-treated for 2h with 100 nM ES936. B) the breast cancer cell line MCF-7 cells, C) the breast cancer cell line MDA-MB-231 transfected with empty vector (NQO1-) or with the gene

  12. Northern Michigan FruitNet 2014 Northwest Michigan Horticultural Research Center

    Renewable Energy Websites

    April 8, 2014 CALENDAR OF EVENTS 4/10 IPM Fruit Tree Kick-off NWMHRC 4/10 Tractor Safety Class #1 Meeting NWMHRC 4/17 Tractor Safety Class #2 NWMHRC 4/21 MDA Pesticide Applicator Testing NWMHRC 4/22 Responding to an S.O.S. from the Commercial Bee Industry ­ Webinar 4/24 Tractor Safety Class #3 NWMHRC 5

  13. NATURE METHODS | VOL.5 NO.4 | APRIL 2008 | 279 CORRESPONDENCE

    Chemistry Websites

    Cai, Long

    call rate is >75.0% (Fig. 1b). Imputation rescued 328 (14.9%) samples and 80,613 (16.7%) SNPs for a 29MDA-amplified (ML) and genomic (58C) DNA samples were 95.9% and 98.5%, respectively. Furthermore%, the Affymetrix 500K array experienced a 6.5% drop in coverage from 60.6% to 54.1% when measured on the HapMap

  14. Motile Properties of Cytoplasmic Dynein Samara L. Reck-Peterson,a Ronald D.Vale,b and Arne Gennerichc

    Biology and Medicine Websites

    cofactors, the dynactin complex, LIS1, and NudE. 8.1 IntroDuCtIon Cytoplasmic dynein (referred to as dynein complex, LIS1, and NudE. One of the challenges for studying the motile properties of dynein has been its complex, LIS1, and NudE brings the total complex size to ~2.5 MDa. The HC itself is quite complicated

  15. The Asymmetric Drift of the Thick Disk Population

    Astrophysics (arXiv)

    Devendra Ojha; Annie C. Robin; Olivier Bienayme

    1994-08-21

    We investigate the kinematics of the intermediate population using the photometric and astrometric sample surveys towards two opposite directions (galactic centre and anticentre) at intermediate latitude. A multivariate discriminant analysis (MDA) is used to distinguish the `Thick Disk' from other populations with the help of the Besan\\c con model of population synthesis. The data constrain the asymmetric drift of the intermediate population, which is found to be 40$\\pm$10 km sec$^{-1}$ and does not depend on the galactic radius.

  16. IEEE PHOTONICS TECHNOLOGY LETTERS, VOL. 9, NO. 10, OCTOBER 1997 1301 Quantum Capture Times at Room Temperature

    Engineering Websites

    Klotzkin, David

    -organized quantum-dot (QD) lasers with Ith = 15­30 mA, and small-signal modulation bandwidth f03 dB = 4.5 GHz, have and Defense Advanced Research Projects Agency (COST) under Grant MDA972-94-1- 004. The authors Temperature in High-Speed In Ga As­GaAs Self-Organized Quantum-Dot Lasers David Klotzkin, Kishore Kamath

  17. Society Profile -CI The Composites IlISIitate

    Engineering Websites

    F Fiber Reinforced Polymers R p Society Profile - CI The Composites IlISIitate I Winter 1991 Volume~ in an identilied hfOh-Qro~th mar~et The MDA is currently involl'ed withpro)- lI'arns in tv-u IllCU5ed areas: mar1f: A PlOtilt in Prowess"; "Composites & P/aslica in CO/lSIr(.(:!im·;a S)lOOal putllicatim ~f "Engineering

  18. Attenuation study for Tibet Water Cherenkov Muon Detector Array-A

    HEP - Experiment (arXiv)

    Quanbu Gou; Yiqing Guo; Cheng Liu; Xiangli Qian; Zhengtao Hou

    2011-08-14

    This work aims at online calibrating the signal attenuation of the long cable used in Tibet Water Cherenkov Muon detector array-A (Tibet MD-A) under the 37 000 m2 Tibet air shower array. Based on the waterproof connection of the PMT (R3600_06) with the signal cable, and the characters of the high voltage divider, terminal reflection method is explored and used for measuring the signal attenuation with a practical way to eliminate the contribution of the pulse baseline (pedestal). Comparison measurement between it and QDC (Charge-to-Digital Conversion) data taking method are carried out by using open-ended cables, confirming that terminal reflection method is a fast and convenient method, and suitable to online calibrate the signal attenuation for Tibet MD-A. At 26\\degree C, the measured attenuation coefficient with the 250-m cable, permanently connected to the PMT, is ~13.9%. Also, the cable frequency response is measured by using the sinusoidal signals, which could be used to study the time dispersion of the real signal produced with Tibet MD-A detector via Fourier analysis.

  19. Standard test method for analysis of urine for uranium-235 and uranium-238 isotopes by inductively coupled plasma-mass spectrometry

    CERN Preprints

    American Society for Testing and Materials. Philadelphia

    2010-01-01

    1.1 This test method covers the determination of the concentration of uranium-235 and uranium-238 in urine using Inductively Coupled Plasma-Mass Spectrometry. This test method can be used to support uranium facility bioassay programs. 1.2 This method detection limits for 235U and 238U are 6 ng/L. To meet the requirements of ANSI N13.30, the minimum detectable activity (MDA) of each radionuclide measured must be at least 0.1 pCi/L (0.0037 Bq/L). The MDA translates to 47 ng/L for 235U and 300 ng/L for 238U. Uranium– 234 cannot be determined at the MDA with this test method because of its low mass concentration level equivalent to 0.1 pCi/L. 1.3 The digestion and anion separation of urine may not be necessary when uranium concentrations of more than 100 ng/L are present. 1.4 Units—The values stated in picoCurie per liter units are to be regarded as standard. The values given in parentheses are mathematical conversions to SI units that are provided for information only and are not considered standard. 1....

  20. Kinematical Properties of the Thick Disk of the Galaxy

    Astrophysics (arXiv)

    Devendra Ojha

    1994-10-20

    We try here to find new constraints on thick disk population using samples at intermediate latitude and North Galactic Pole, which include photometry and proper motions. The algorithm SEM (Stochastic-Estimation-Maximization; Celeux \\& Deibolt 1986) was used to deconvolve the stellar components up to large distances above the plane, allowing to study of their statistical properties independently. The multivariate discriminant analysis (MDA) is used to qualify the thick disk using observations in multidimensional space (V,B-V,U-B, $\\mu_{l}$ \\& $\\mu_{b}$).

  1. Un cadre de conception pour r\\'eunir les mod\\`eles d'interaction et l'ing\\'enierie des interfaces

    CERN Preprints

    Lard, Jérôme; Grisvard, Olivier; Faure, David

    2008-01-01

    We present HIC (Human-system Interaction Container), a general framework for the integration of advanced interaction in the software development process. We show how this framework allows to reconcile the software development methods (such MDA, MDE) with the architectural models of software design such as MVC or PAC. We illustrate our approach thanks to two different types of implementation for this concept in two different business areas: one software design pattern, MVIC (Model View Interaction Control) and one architectural model, IM (Interaction Middleware).

  2. Com pone nts J a v a .ne t

    Computer Technologies and Information Sciences Websites

    da Silva, Alberto Rodrigues

    M ode ls X M L IR M L Com pone nts E x e J a v a .ne t IR S ys te m X Te m pla te s G e ne ra l IR Te m pla te s Aplic a tionTe m pla te s Conc e ptua l IR S ys te m b a se d b a se d l i n ke r co d-based approach (MDA) for the design and creation of Information Retrieval (IR) systems. This is based

  3. Attenuation study for Tibet Water Cherenkov Muon Detector Array-A

    CERN Preprints

    Gou, Quanbu; Liu, Cheng; Feng, Zhaoyang; Qian, Xiangli; Hou, Zhengtao

    2011-01-01

    The attenuation study of the long cable used in Tibet Water Cherenkov Muon Detector Array-A, called Tibet MD-A (one of 12 Tibet MD detectors), under the 37000 m2 Tibet air shower array, is reported. The cable frequency response is measured by using the sinusoidal signals, with which the influence of the cable on the pulse rise time is obtained. For the reason that the commercial 20 inch PMT (R3600_06) has a waterproof connection with the signal cable, one end of the signal cable is permanently connected to the PMT. Terminal reflection method is tested and used for measuring the signal attenuation. During the measurement, a practical way to eliminate the uncertainty caused by the baseline of the signal is achieved. To check the terminal reflection method, comparison measurement between it and QDC data taking method are carried out by using open-ended cables. The confirmed terminal reflection method is a fast and convenient method being suitable to online measure the signal attenuation for Tibet MD-A. The measu...

  4. A model-driven approach for composing SAWSDL semantic Web services

    CERN Preprints

    Belouadha, Fatima-Zahra; Roudies, Ounsa

    2010-01-01

    Composing Web services is a convenient means of dealing with complex requests. However, the number of Web services on the Internet is increasing. This explains the growing interest in composing Web services automatically. Nevertheless, the Web services' semantics is necessary for any dynamic composition process. In this article, we present an MDA approach to develop and compose SAWSDL semantic Web services. To model Web services, we use a UML profile which is independent of the description standards. The SAWSDL interface files are generated by using transformation rules. To model the behavior of a composite Web service and generate its executable BPEL file, we use the BPMN notation in a platform of modeling and implementing business process. The main contribution of this work is the easy and extensible solution to a model-driven development of the semantic atomic and composite Web services.

  5. The Gemini NICI Planet-Finding Campaign: The Frequency of Giant Planets Around Debris Disk Stars

    CERN Preprints

    Wahhaj, Zahed; Nielsen, Eric L; Biller, Beth A; Hayward, Thomas L; Close, Laird M; Males, Jared R; Skemer, Andrew; Ftaclas, Christ; Chun, Mark; Thatte, Niranjan; Tecza, Matthias; Shkolnik, Evgenya L; Kuchner, Marc; Reid, I Neill; Pino, Elisabete M de Gouveia Dal; Alencar, Silvia H P; Gregorio-Hetem, Jane; Boss, Alan; Toomey, Douglas N C Lin Douglas W

    2013-01-01

    We have completed a high-contrast direct imaging survey for giant planets around 57 debris disk stars as part of the Gemini NICI Planet-Finding Campaign. We achieved median H-band contrasts of 12.4 mag at 0.5" and 14.1 mag at 1" separation. Follow-up observations of the 66 candidates with projected separation 5MJup planet beyond 80 AU, and 3MJup planet outside of 40 AU, based on hot-start evolutionary models. We model the population of directly-imaged planets as d^2N/dMda ~ m^alpha a^beta, where m is planet mass and a is orbital semi-major axis (with a maximum value of amax). We find that beta 1.7. Likewise, we find that beta 3MJup planet beyond 10 AU, and beta 40 AU and planet masses > 3 MJup do not carve the central holes in these disks.

  6. Spin-dipole strengths and tensor correlation effects for ${}^{208}{\\rm Pb}(p,n)$ at 295 MeV

    Nuclear Experiment (arXiv)

    T. Wakasa for the RCNP-E57; E59 collaborations

    2010-04-29

    We performed the multipole decomposition analysis (MDA) for the ${}^{208}{\\rm Pb}(p,n)$ data in order to obtain the spin-dipole (SD) strengths separated into each $\\Delta J^{\\pi}$ contribution $dB({\\rm SD}_{\\Delta J^{\\pi}};\\omega)/d\\omega$. The random phase approximation (RPA calculations reproduce the total SD strength reasonably well, whereas some discrepancies are found for separated SD strength. The centroids of the resonances are slightly lower and higher than the theoretical predictions for $1^-$ and $2^-$, respectively. These softening and hardening effects observed in $1^-$ and $2^-$ distributions would be due to the tensor correlation effects not included in the present RPA calculations.

  7. Avoiding another Green Elephant - A Proposal for the Next Generation HLA based on the Model Driven Architecture

    CERN Preprints

    Tolk, Andreas

    2010-01-01

    When looking through the proceedings of the recent Simulation Interoperability Workshops, a lot of papers - some of them even awarded by the committee - are dealing with alternative concepts outside or beyond the High Level Architecture (HLA): Web Services, the extensible Markup Language (XML), Java Beans, Simple Object Access Protocol (SOAP), etc. Similarly, requirements driven by interoperability issues have resulted in the need to use meta modeling, adaptive models, and common repositories. The use of the Unified Modeling Language (UML) as a model description language is also rapidly becoming a standard. All these concepts have relations to the HLA, but they are not part of it. There seems to be the danger that HLA is overrun by respective developments of the free market and will become irrelevant finally. ... This paper introduces the MDA concept and shows, how the HLA can be integrated to become a standard stub for simulation applications of legacy systems, systems under development, and systems of the f...

  8. Interferometric Astrometry of the Detached White Dwarf - M Dwarf Binary Feige 24 Using Hubble Space Telescope Fine Guidance Sensor 3: White Dwarf Radius and Component Mass Estimates

    Astrophysics (arXiv)

    G. F. Benedict; B. E. McArthur; O. G. Franz; L. H. Wasserman; E. Nelan; J. Lee; L. W. Fredrick; W. H. Jefferys; W. van Altena; E. L. Robinson; W. J. Spiesman; P. J. Shelus; P. D. Hemenway; R. L. Duncombe; D. Story; A. L. Whipple; A. Bradley

    2000-01-21

    With HST FGS 3 we have determined a parallax for the white dwarf - M dwarf interacting binary, Feige 24. The white dwarf (DA) component has an effective temperature, T_eff of approximately 56,000 K degrees. A weighted average with past parallax determinations (pi_abs = 14.6 +- 0.4 milliseconds of arc) narrows the range of possible radius values, compared to past estimates. We obtain R_DA = 0.0185 +- 0.0008 R_solar with uncertainty in the temperature and bolometric correction the dominant contributors to the error. FGS photometry provides a light curve entirely consistent with reflection effects. A recently refined model Mass-Luminosity Relation (Baraffe et al. 1998) for low mass stars provides a mass estimate for the M dwarf companion, M_dM = 0.37 +- 0.20 M_solar, where the mass range is due to metallicity and age uncertainties. Radial velocities from Vennes and Thorstensen (1994) provide a mass ratio from which we obtain M_DA = 0.49+0.19-0.05 ~ M_solar. Independently, our radius and recent log_g determinations yield 0.44 < M_DA < 0.47 M_solar. In each case the minimum DA mass is that derived by Vennes & Thorstensen from their radial velocities and Keplerian circular orbits with inclination <= 90 degrees. Locating Feige 24 on an M - R plane suggests a carbon core. Our radius and these mass estimates yield a gamma_grav inconsistent with that derived by Vennes & Thorstensen. We speculate on the nature of a third component whose existence would resolve the discrepancy.

  9. White Dwarf Mass Distribution in the SDSS

    Astrophysics (arXiv)

    S. O. Kepler; S. J. Kleinman; A. Nitta; D. Koester; B. G. Castanheira; O. Giovannini; A. F. M. Costa; L. Althaus

    2007-01-17

    We determined masses for the 7167 DA and 507 DB white dwarf stars classified as single and non-magnetic in data release four of the Sloan Digital Sky Survey (SDSS). We obtained revised Teff and log g determinations for the most massive stars by fitting the SDSS optical spectra with a synthetic spectra grid derived from model atmospheres extending to log g=10.0. We also calculate radii from evolutionary models and create volume-corrected mass distributions for our DA and DB samples. The mean mass for the DA stars brighter than g=19 and hotter than Teff=12000K is M(DA)= 0.593+/-0.016M(Sun). For the 150 DBs brighter than g=19 and hotter than Teff=16000K, we find M(DB)=0.711+/-0.009 M(Sun). It appears the mean mass for DB white dwarf stars may be significantly larger than that for DAs. We also report the highest mass white dwarf stars ever found, up to 1.33 M(Sun).

  10. Tidal synchronization of close-in satellites and exoplanets. II. Spin dynamics and extension to Mercury and exoplanets host stars

    CERN Preprints

    Ferraz-Mello, Sylvio

    2015-01-01

    This paper deals with the application of the creep tide theory (Ferraz-Mello, CeMDA 116, 109, 2013) to the rotation of close-in satellites, Mercury, close-in exoplanets and their host stars. The solutions show two extreme cases: close-in giant gaseous planets, with fast relaxation (low viscosity) and satellites and Earth-like planets, with slow relaxation (high viscosity). The rotation of close-in gaseous planets follows the classical Darwinian pattern: it is tidally driven towards a stationary solution which is synchronized, but, if the orbit is elliptical, with a frequency larger than the orbital mean-motion. The rotation of rocky bodies, however, may be driven to several attractors whose frequencies are 1/2,1,3/2,2,5/2 ... times the mean-motion. The number of attractors increases with the viscosity of the body and with the orbital eccentricity. The classical example is Mercury, whose rotational period is 2/3 of the orbital period (3/2 attractor). The planet behaves as a molten body with a relaxation that a...

  11. Whole body counter surveys of Miharu-town school children for four consecutive years after the Fukushima NPP accident

    CERN Preprints

    Hayano, Ryugo S; Miyazaki, Makoto; Satou, Hideo; Sato, Katsumi; Masaki, Shin; Sakuma, Yu

    2015-01-01

    Comprehensive whole-body counter surveys of Miharu town school children have been conducted for four consecutive years, in 2011-2014. This represents the only long-term sampling-bias-free study of its type conducted after the Fukushima Dai-ichi accident. For the first time in 2014, a new device called the Babyscan, which has a low $^{134/137}$Cs MDA of $< 50$ Bq/body, was used to screen the children shorter than 130 cm. No child in this group was found to have detectable level of radiocesium. Using the MDAs, upper limits of daily intake of radiocesium were estimated for each child. For those screened with the Babyscan, the upper intake limits were found to be <1 Bq/day for $^{137}$Cs. Analysis of a questionnaire filled out by the children's parents regarding their food and water consumption shows that the majority of Miharu children regularly consume local and/or home-grown rice and vegetables. This however does not increase the body burden.

  12. Radiometric Determination of Uranium in Natural Waters after Enrichment and Separation by Cation-Exchange and Liquid-Liquid Extraction

    Nuclear Experiment (arXiv)

    I. Pashalidis; H. Tsertos

    2003-04-28

    The alpha-radiometric determination of uranium after its pre-concentration from natural water samples using the cation-exchange resin Chelex-100, its selective extraction by tributylphosphate and electrodeposition on stainless steel discs is reported. The validity of the separation procedure and the chemical recoveries were checked by addition of uranium standard solution as well as by tracing with U-232. The average uranium yield was determined to be (97 +- 2) % for the cation-exchange, (95 +- 2) % for the liquid-liquid extraction, and more than 99% for the electrodeposition. Employing high-resolution alpha-spectroscopy, the measured activity of the U-238 and U-234 radioisotopes was found to be of similar magnitude; i.e. ~7 mBq/L and ~35 mBq/L for ground- and seawater samples, respectively. The energy resolution (FWHM) of the alpha-peaks was 22 keV, while the Minimum Detectable Activity (MDA) was estimated to be 1 mBq/L (at the 95% confidence limit).

  13. Nanomechanical and topographical imaging of living cells by Atomic Force Microscopy with colloidal probes

    Condensed Matter (arXiv)

    Luca Puricelli; Massimiliano Galluzzi; Carsten Schulte; Alessandro Podestà; Paolo Milani

    2015-02-05

    Atomic Force Microscopy (AFM) has a great potential as a tool to characterize mechanical and morphological properties of living cells; these properties have been shown to correlate with cells' fate and patho-physiological state in view of the development of novel early-diagnostic strategies. Although several reports have described experimental and technical approaches for the characterization of cell elasticity by means of AFM, a robust and commonly accepted methodology is still lacking. Here we show that micrometric spherical probes (also known as colloidal probes) are well suited for performing a combined topographic and mechanical analysis of living cells, with spatial resolution suitable for a complete and accurate mapping of cell morphological and elastic properties, and superior reliability and accuracy in the mechanical measurements with respect to conventional and widely used sharp AFM tips. We address a number of issues concerning the nanomechanical analysis, including the applicability of contact mechanical models and the impact of a constrained contact geometry on the measured elastic modulus (the finite-thickness effect). We have tested our protocol by imaging living PC12 and MDA-MB-231 cells, in order to demonstrate the importance of the correction of the finite-thickness effect and the change in cell elasticity induced by the action of a cytoskeleton-targeting drug.

  14. Summary on m_{c,b}(m_{c,b}) and precise f_{D_(s),B_(s)} from heavy-light QCD spectral sum rules

    HEP - Experiment (arXiv)

    Stephan Narison

    2012-09-13

    We summarize recent results obtained in [1] on the running m_{c,b}(m_{c,b}) in the MS scheme and f_{D_(s), B_(s)} using QCD spectral sum rules (QSSR) known to N2LO PT series, including all dimension-six NP condensate contributions in the full QCD theory, an estimate of the N3LO terms based on the geomteric growth of the PT series and using the most recent values of the QCD input parameters given in Table [1]. The study of the effects of the subtraction scale \\mu on "different QSSR data" and the use (for the first time) of the Renormalization Group Invariant (RGI) scale independent quark masses in the analysis are emphasized. The estimates [rigourous model-independent upper bounds] reported in Table 2: f_D/f_\\pi=1.56(5)[< 1.68(1)], f_B/f_\\pi=1.58(5)[< 1.80(3)] and f_{D_s}/f_K= 1.58(4) [< 1.63(1)], f_{B_s}/f_K=1.50(3)[< 1.61(3.5)], improve previous QSSR estimates. The remarkable agreements with some of the experimental data on f_{D,D_s} and with lattice simulations within dynamical quarks confirm both the success of the QSSR semi-approximate approach based on the OPE in terms of the quark and gluon condensates and of the Minimal Duality Ansatz (MDA) for parametrizing the hadronic spectral function which we have tested from the complete data of the J/\\psi and \\Upsilon systems. The running quark masses m_c({m_c})=1286(66) MeV and m_b({m_b})= 4236(69) MeV from M_{D,B} are in good agreement though less accurate than the ones from recent J/\\psi and \\Upsilon sum rules.

  15. A fresh look into m_{c,b} and precise f_{D_(s),B_(s)} from heavy-light QCD spectral sum rules

    HEP - Experiment (arXiv)

    Stephan Narison

    2012-12-08

    Using recent values of the QCD (non-) perturbative parameters given in Table 1 and an estimate of the N3LO QCD perturbative contributions based on the geometric growth of the PT series, we re-use QCD spectral sum rules (QSSR) known to N2LO PT series and including all dimension-six NP condensate contributions in the full QCD theory, for improving the existing estimates of {m}_{c,b} and f_{D_(s)}, f_{B_(s)} from the open charm and beauty systems. We especially study the effects of the subtraction point on "different QSSR data" and use (for the first time) the Renormalization Group Invariant (RGI) scale independent quark masses in the analysis. The estimates [rigourous model-independent upper bounds within the SVZ framework] reported in Table 8: f_D/f_\\pi=1.56(5)[< 1.68(1)], f_B/f_\\pi=1.58(5)[< 1.80(3)] and f_{D_s}/f_K= 1.58(4) [< 1.63(1)], f_{B_s}/f_K=1.50(3)[< 1.61(3.5)], which improve previous QSSR estimates, are in perfect agreement (in values and precisions) with some of the experimental data on f_{D,D_s} and on recent lattice simulations within dynamical quarks. These remarkable agreements confirm both the success of the QSSR semi-approximate approach based on the OPE in terms of the quark and gluon condensates and of the Minimal Duality Ansatz (MDA) for parametrizing the hadronic spectral function which we have tested from the complete data of the J/\\psi and \\Upsilon systems. The values of the running quark masses m_c(m_c)=1286(66) MeV and m_b(m_b)= 4236(69) MeV from M_{D,B} are in good agreement though less accurate than the ones from recent J/\\psi and \\Upsilon sum rules.

  16. PG1115+166 - a long period DA+DB binary

    Astrophysics (arXiv)

    P. F. L. Maxted; M. R. Burleigh; T. R. Marsh; N. P. Bannister

    2002-03-29

    We present spectra of the DAB white dwarf PG1115+166. Radial velocity measurements of the Balmer lines and the HeI6678 line show that this is a binary white dwarf with a period of 30.09d in which the Balmer lines move in anti-phase to the HeI line, i.e., PG1115+166 is a DA+DB binary. The minimum masses of the stars are M_DA=0.43+-0.15 solar masses and M_DB=0.52+-0.12 solar masses. The separation of the stars is about 45 solar radii which is much smaller than a typical AGB progenitor of a white dwarf, implying that there has been at least one common envelope phase in this binary. Indeed, it is possible that this binary may have suffered up to three mass transfer episodes - two associated with the red giant phase prior to the formation of each white dwarf and a third associated with the ``born-again'' red giant phase of the DB white dwarf. PG1115+166 has the longest orbital period of any post common envelope white dwarf - white dwarf binary found to date. Published models for the formation of white dwarf - white dwarf binaries do not predict any white dwarfs with the combination of long orbital period and high mass found in PG1115+166. We conclude that PG1115+166 is a key object for testing models of binary star evolution and it may also be a key object for our understanding of the formation of DB white dwarfs. We outline the observational tests which can be applied to scenarios for the formation of PG1115+166 and apply them to the simplest case of a single common envelope phase. This suggests that some part of the internal energy stored in the envelope of the AGB star, e.g., as ionized hydrogen, may have contributed to the ejection of the common envelope, but there are several unanswered questions concerning this simple scenario.