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Sample search results for: a1 adenosine receptors

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1 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system after chronic A1 receptor
 

Summary:  Chapter 7 No evidence for cross-talk between the adenosine A1 and the serotonin-1A receptor system... of the adenosine A1 receptor agonist N6 -cyclopentyladenosine (CPA) not only desensitizes the adenosine ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
2 Adenosine-Mediated Presynaptic Modulation of Glutamatergic Transmission in the Laterodorsal Tegmentum
 

Summary:  adenosine A1 receptors (Rainnie et al., 1994). However, adenosine effects on syn- aptic inputs to LDT... IPSCs were reduced by adenosine (50 M). A presynaptic site of action for adenosine A1 ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
3 0022.3565/87/2423-0882S00.00/0 THE JOURNALor PHARMACOLOGYAND EXP!JUNENTALTHERAPEIITICS
 

Summary:  at A1 receptors: blockade of the hypotensive effect of the same series of adenosine ago- nists was used... adenosine receptors in this re- sponse. The potent antagonist XAC displayed considerable A1 selectivityas... the ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
4 Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle
 

Summary:  Data "Adenosine A1 receptor activation stimulates SREBP1 translocation... problem. Moreover, the demonstration that adenosine A1 receptors may play... by either an ...

  

Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
5 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  surface adenosine receptors (12). Four subtypes of adenosine receptors have been defined, A1, A2a, A2b... . Affinity-purified rabbit polyclonal anti-rat adenosine A1 receptor antibody ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
6 Behavioral/Systems/Cognitive A Circadian Clock and Light/Dark Adaptation Differentially
 

Summary:  by the presence of retinal adenosine metabolic pathway enzymes and receptor subtypes A1 and A2A and by the effects... ) Adenosine in vertebrate retina: localization, receptor characterization, and function. Cell Mol Neurobiol 11... Adenosine in ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
7 Biochemistry Insect Biochemistry and Molecular Biology 35 (2005) 381389
 

Summary:  .J., Christoffel, F., Timmer, J., Northoff, H., Berger, M., Van Calker, D., 1996. Both adenosine A1- and A2... mechanisms involve interactions of elevated adenosine (Table 3B) with adenosine receptors on lymphocytes... -[alpha] production via ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
8 The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
 

Summary:  the pharmacological characterization of novel receptors. Moreover, adenosine A1 and P2Y1 receptors have been shown... previously to form heterodimers that enable the A1 receptor to bind and respond to ADP [6], and thus... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
9 0022.3565/86/2362.0350S02.oo/0 THE JOURN"L or PH..R COLO<:Y..,..D EXPF.H'''ENT''L THER"PEl'TIC~
 

Summary:  with specific receptors on pre- or post- synaptictissues (Dalyet 01.,1981).Presynaptically,adenosine inhibits... , particularly in tissues containing multi- ple subpopulations of adenosine receptors mediating different... analogs were also adminis- tered in an attempt to characterize the ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
10 J Physiol 589.2 (2011) pp 283295 283 The dynamics of single spike-evoked adenosine release
 

Summary:  , the modulation of adenosine release by specific G-protein coupled receptor agonists strongly suggests... mediated by glutamate receptor activation In control conditions (absence of 4-AP), adenosine release... of the adenosine release stems from AMPA receptor ...

  

Source: Richardson, Magnus - Systems Biology Centre, University of Warwick

 

Collection: Biology and Medicine

 
11 The American Journal of Physiology, Renal Physiology --Manuscript F-00256-2007 --
 

Summary:  mechanism of renal blood flow autoregulation and the autoregulatory role of A1 adenosine receptors in mice... to A1-adenosine receptor (A1AR) -agonist ...

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
12 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  of cellular functions by interacting with specific cell surface G protein-coupled receptors (A1, A2a, A2b... , Yu JG, Guzman J, Xue J, Kim M, Wang YZ, and Cooke HJ. Differential gene expression of adenosine A1, A... Agonist-induced polarized trafficking and surface ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
13 Adenosine is crucial for deep brain stimulationmediated attenuation of tremor
 

Summary:  , resulting in accumulation of its catabolic product, adenosine. Adenosine A1 receptor activation depresses... infusion of A1 receptor agonists directly reduces tremor, whereas adenosine ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
14 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... heart and their possible inter- action with adenosine A1-receptors . Circulation 1992, 86: 13106. 74... : 30311. 76. Yao, Z. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
15 Adenosine A3 receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury
 

Summary:  demonstrated a potent cytoprotective role of adenosine A1, A2A, and A3 receptors in ischemia and reperfusion... mediates protection is not the same. The adenosine A3 receptor, but not the A1 or A2A ...

  

Source: Campbell, Kevin P. - Department of Physiology and Biophysics, University of Iowa

 

Collection: Biology and Medicine

 
16 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, A2A... (ATP/adenosine diphosphate (ADP)) receptors was proposed by Burnstock in 19786. This helped resolve... and inactivation of ATP, and autoregulation via ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
17 ADENOSINE, PROLONGED WAKEFULNESS, AND A1-ACTIVATED NF-UB DNA BINDING IN THE BASAL FOREBRAIN OF THE RAT
 

Summary:  of adenosine increased NF-UB DNA binding while pretreatment of the slices with the A1 adenosine receptor... during prolonged wakefulness, act through an A1 adenosine receptor and a second messenger ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
18 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  Signaling The Periphery Adenosine A1, A2A, A2B, and A3 receptors (ARs) are all present at peripheral sites... Adenosine receptors, particularly A1Rs, also contribute to pain regulation by actions at central sites... as ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 The birth and postnatal development of purinergic signalling G. Burnstock,1
 

Summary:  through adenosine receptors. This suggestion was based largely on the observation that adenosine and its... that several factors including adenosine receptors, NO and KATP channels contribute, and may act... vesical parasympathetic ganglia, purines suppressed synaptic transmission ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
20 Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion
 

Summary:  , adenosine modulates cellular excitability through activation of A1 receptors that are linked to G... of retinal ganglion cells by the adenosine receptor agonist NECA is mediated by activation of A1 ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine


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21 Biochemistry Insect Biochemistry and Molecular Biology 37 (2007) 318329
 

Summary:  for adenosine and adenosine receptor agonist binding in point mutation experiments for the human A1, A2A and A3... 50 values for adenosine-induced cAMP response of the human A1, A2A, A2B and A3 receptors ...

  

Source: Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
22 The influence of hypothermia on P2 receptor-mediated responses of frog skeletal muscle
 

Summary:  of Pharmacology 509 (2005) 187­193 191 #12;was shown that in guinea-pig tissues, adenosine A1 receptor... that presynaptic P1 receptors in frog neuromuscular junction belong to A1 subtype since 1,3- dipropyl-8... -cyclopentylxantine (DPCPX), a ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 Purinergic Signaling and Vascular Cell Proliferation and Death Geoffrey Burnstock
 

Summary:  established.1,2 P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B, and A3) have been identified... activation. An 8-phenyltheophyl- line­resistant mitogenic action of adenosine, which was not mimicked by A1... - latation. P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
24 Adenosine Released by Astrocytes Contributes to Hypoxia-Induced Modulation of Synaptic Transmission
 

Summary:  of excitatory synaptic transmission me- diated by activation of presynaptic A1 adenosine receptors. The glia... -specific metabolic inhibitor fluorocitrate (FC) was as effective as the A1 adenosine receptor antagonist CPT... ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
25 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... receptors are also involved in various forms of oligodendrocyte pathology. Genetic deletion of A1 adenosine... ) with ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
26 Purinergic regulation of vascular tone and remodelling
 

Summary:  ; Burnstock, 2007a). P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B 63 Autonomic & Autacoid... vasodilatation or vasoconstriction. P1 (A1) receptors on nerve terminals of sympathetic and sensory nerves... distinguished from ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  .deaminase Inosine Smooth muscle receptors P2 Purinoceptor 5 -nucleo- ATP resynthesis Adenosine Adenosine uptake... IP3 a1 EJP Ca2+ influx Ca2+ release Sympathetic nerve ATP P2X NA ATP NPY ATP NO VIP CGRP SP ATP ACh... nerves can be released together. With NA acting via the postjunctional ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
28 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  receptors with non-P2Y receptors is rat P2Y1 and adenosine A1 receptors co-expressed in HEK293 cells. It has... Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
29 *National Institute of Child Health and Human
 

Summary:  - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... roles are not fully known. A1 , A2A , A2B and A3 adenosine receptors have distinct but frequently... concentra- tions of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
30 RESEARCH PAPER Role of ATP and related purines in inhibitory
 

Summary:  , Table 3). Effects of A1, A2A, A2B and A3 receptor antagonists on relaxations to EFS, adenosine and NECA... , inhibited the relaxations to EFS, adenosine and NECA. The lack of effect of the A1, A2B and A3 receptor... interacts ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
31 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  receptor (see Marshall, 2005). Also the A1R= P2Y1R heteromerization leads to the appearance of an A1... accumbens (Diaz-Cabiale et al., 2001). In higher doses CGS 21680 but not an A1 receptor agonist could antag... cells were ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
32 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  inhibitory modulator through P1(A1 ) receptors, but ATP itself can act presynaptically either to inhibit... 1 (adenosine) A1 Brain, spinal cord, testis, heart, autonomic nerve terminals Prejunctional... , and in a rat model of Parkinson's disease, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
33 The Rockefeller University Press $30.00 J. Exp. Med. Vol. 206 No. 11 2417-2427
 

Summary:  ). The immunoregulatory attributes of adenosine are mediated via four transmembrane adenosine receptors: A1, A2A, A2B... and neutrophils express all four adenosine receptors, whereas B cells harbor only A2A (Thiel et al., 2003... to generate ...

  

Source: Chicago, University of - Department of Microbiology

 

Collection: Biology and Medicine

 
34 Endothelium-Derived Vasoconstriction by Purines and Pyrimidines
 

Summary:  , and P2Y2 receptors in some vessels) on smooth muscle, resulting in vasoconstric- tion. P1(A1) receptors... by To¨lle et al1 claims to show for the first time that adenosine 5 -tetraphosphate (AP4) is released... , that AP4 is the most potent mediator of vascular smooth muscle constric- ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
35 ATP signalling in epilepsy Ashwin Kumaria & Christos M. Tolias &
 

Summary:  hippocampal region have the opposite effect to A1 receptors in a piriform cortex kindling model. Adenosine... ) Adenosine acting via A1 receptors, controls the transition to status epilepticus-like behaviour... :1501­1515 15. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
36 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  cells transfected with pcDNA3.1 (mock), human adenosine A1 receptor (A1R), or human A2AR were... neuromodulator that binds to at least four known G-protein- coupled receptors in the brain (A1, A2A, A2B, ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
37 Structure based prediction of subtype-selectivity for adenosine receptor antagonists
 

Summary:  into the structural basis of ligand subtype selectivity within the family of adenosine receptors (AR: A1, A2A, A2B... ) of ligand and decoy sets were similar. 2.2. Homology modeling of A1, A2B and A3 adenosine receptor ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
38 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  t Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests... receptor function [10,32]. Adenosine type A1 and A2A receptors on glutamatergic terminals play a ...

  

Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University

 

Collection: Biology and Medicine

 
39 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  also form heterodimeric com- plexes [64] or with other receptors. For example, adenosine A1 receptors... and adenosine A1 receptors have also been shown to form func- tionally interactive heteromeric ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
40 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... with the excitatory actions of ATP on nerve cells. Adenosine (P1) receptor activation can inhibit ATP release. ATP... receptor responses ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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41 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  between adenosine and dopa- mine receptors, the A1R/mGluR1 and A2AR/mGluR5 in- teractions facilitate... , Canela EI, Rondin S, Lew JY, Watson S, Zoli M, et al. (2000) Dopamine D1 and adenosine A1 receptors form... GPCRs ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
42 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... adenosine. This is suggestive of P2Y1-mediated relaxation and perhaps a further P2Y receptor subtype... classification of receptors for ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
43 Neuron Glia Biology, 2004, 1, 245252. 2004 Cambridge University Press doi:10.1017/S1740925X0500013X Printed in the United Kingdom
 

Summary:  ganglion cells by releasing ATP, which, following hydrolysis to adenosine, activates neuronal A1 receptors... by ectoenzymes, might also activate A1 adenosine receptors (Braas et al., 1987) and hyperpolarize ganglion cells... ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
44 Dual control of vascular tone and remodelling by ATP released from nerves and endothelial cells
 

Summary:  or vasoconstriction. P1 (A1) receptors on nerve terminals of sympathetic and sensory nerves mediate adenosine (arising... for these receptors in modulating adhesion junctions between endothelial cells [46]. Adenosine produced after... . Adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
45 Double-Stranded RNA Adenosine Deaminases ADAR1 and ADAR2 Have Overlapping Specificities
 

Summary:  . Calculations that include all adenosines give a value of 28% deamination for both enzymes. hA2, hADAR2; xA1, x... Double-Stranded RNA Adenosine Deaminases ADAR1 and ADAR2 Have Overlapping Specificities Katrina A... , 2000 ABSTRACT: Adenosine deaminases that act on RNA (ADARs) deaminate ...

  

Source: Bass, Brenda L. - Departments of Biochemistry & Human Genetics, University of Utah

 

Collection: Biology and Medicine

 
46 Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation
 

Summary:  Receptor subtype Phenotypereference P1 Adenosine receptors A1 (i) Behavioural phenotype: increased... plasma renin in adenosine A1 receptor-deficient mice. Am J Physiol Regul Integr Comp Physiol 2001; 281: ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... breakdown to adenosine, it acts as a prejunctional inhibitor of transmission via adenosine A1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
48 Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India
 

Summary:  by the selective A1 receptor antagonist 8- cyclopentyl-1,3-dipropylxanthine (DPCPX). The ecto-ATPase inhibitor (ARL... Y metabotropic receptor subtypes, as well as four subtypes of P1 receptors sensitive to adenosine... while adenosine relaxes ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  selectivity of P2X receptors, and why adenosine, polyphosphate or other nucleotides such as GTP and UTP... P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of receptors

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
50 Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  , two subtypes of the P1 (adenosine) receptor were recognised [5,6], but it was not until 1985... Theuse of theophylline, an adenosine receptor antagonist, as an antiasthmatic agent has focussed... . 1979, 33, 999-1005. [6] Londos, C.; Cooper, D.M.; Wolff, J. Subclasses of external ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
51 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... was the presence of purinoceptors (2). A basis for distinguishing P1 (adenosine) from P2 (ATP/ADP) receptors... in rats and dogs by the P2Y receptor agonist ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
52 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  to be involved in ligand recognition (1275). Site-directed mutagenesis of the bovine A1 adenosine receptor... (5, 1206), and most recently, adenosine A1 receptors have been shown to form a heteromeric com- plex... with P2Y1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
53 Purine and pyrimidine receptors G. Burnstock
 

Summary:  with non-P2Y receptors is rat P2Y1 and adenosine A1 receptors coexpressed in HEK293 cells [116]. It has... by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
54 Purine and pyrimidine receptors G. Burnstock
 

Summary:  with non-P2Y receptors is rat P2Y1 and adenosine A1 receptors coexpressed in HEK293 cells [116]. It has... , complementary DNAs (cDNAs) encoding two different P1 receptor subtypes (A1 and A2) were isolated [20], and... , ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
55 General discussion 1. Neurobiological consequences of chronic partial sleep deprivation
 

Summary:  desensitization of the adenosine A1 receptor system, but did not result in a desensitized serotonin-1A signalling... in serotonin-1A receptor sensitivity are the neurotransmitters serotonin and adenosine. It has been... mediator of a serotonin ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
56 A Role for Adenosine Deaminase in Drosophila Larval Development
 

Summary:  functions by binding to G protein-coupled adenosine receptors (A1, A2a, A2b, and A3 in mammals) that can... the adenosine receptor (AdoR), but fat body disintegration, which is promoted by action of the hemocytes, seems... factor-A; AdoR, Drosophila ...

  

Source: Gibson, Matt - Stowers Institute for Medical Research; Žurovec, Michal - Department of Physiology, University of South Bohemia

 

Collection: Biology and Medicine

 
57 Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock
 

Summary:  so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... :85-108 [MEDLINE] Ferre S, Fredholm BB, Morelli M, et al. (1997): Adenosine-dopamine receptor-receptor interactions... Adenosine triphosphate as a neurotransmitter and neuromodulator ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
58 REVIEW ARTICLE The journey to establish purinergic signalling in the gut
 

Summary:  of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system. J Comp Neurol 2001; 439: 46... ­64. 42 Gao N, Hu HZ, Liu S, Gao C, Xia Y, Wood JD. Stimulation of adenosine A1 and A2A receptors by AMP... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
59 Evolutionary origins of the purinergic signalling system G. Burnstock1
 

Summary:  connected by commisures. Early studies showed adenosine to have a modulatory action via A1 and A2 receptors... Physiological Society, doi: 10.1111/j.1748-1716.2009.01957.x 415 #12;receptors A1, A2A, A2B and A3... . These ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
60 Genetics of caffeine consumption and responses to caffeine Amy Yang & Abraham A. Palmer & Harriet de Wit
 

Summary:  conditions, the main effects of caffeine are due to competitive inhibition of adenosine receptors, mainly A1... results in upregulation of adenosine A1 receptors in the CNS, which persists for 15­30 days after... and humans ...

  

Source: Das, Soma - Department of Human Genetics, University of Chicago; Ober, Carole - Committee on Genetics & Department of Human Genetics, University of Chicago

 

Collection: Biology and Medicine


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61 Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
 

Summary:  that by releasing ATP, astrocytes regulate extracellular adenosine acting on synaptic A1 receptors. Astrocytes... of adenosine that acts on A1 receptors in situ (Pascual et al., 2005). Adenosine is a ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
62 Purinergic signalling *Geoffrey Burnstock
 

Summary:  /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... for (a) 1/s and (b) 30/s. Upper trace tension, and lower trace membrane potential. Note the phase... 2B and A3 (see Ralevic & Burnstock, 1998). All P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
63 pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799
 

Summary:  of the Hit Compounds to Mammalian Expressed Adenosine Receptor Subtypes A2A and A1 a Max displacement refers... not explicitlytargetsubtypeselectivity,yieldinghitsthatbindequally well to both A2A and A1 adenosine receptor ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
64 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... or hetero- dimers with other P2Y receptors [52] or with other trans- mitter receptors (e.g. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
65 784 VOLUME 13 | NUMBER 7 | JULY 2010 NATURE NEUROSCIENCE N E W S AN D V I E W S
 

Summary:  by generating adenosine and acti- vating A1R12,13.It will therefore be interesting to determine whether deletion... ,5. Considering the importance of A1R in regulating diverse physiological pro- cesses9, it will be interesting... to determine whether any of the non­pain-related effects ...

  

Source: Johnston, Daniel - Center for Learning and Memory & Section of Neurobiology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
66 Glial Cell Inhibition of Neurons by Release of ATP Eric A. Newman
 

Summary:  that displayed spontaneous spike activity. The inhibition was abolished by the A1 adenosine receptor antagonist... adenosinereceptoractivationevokesneuronalinhibition.A,TheA1 adenosine receptor antagonist DPCPX abolishes the ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
67 In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to
 

Summary:  activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to evaluate... and 4 the yeast system is exploited to study inverse agonism of the human adenosine A2B receptor... . At first, constitutively active mutant (CAM) human ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
68 Ecto-5V-nucleotidase activity in brain membranes of zebrafish (Danio rerio)
 

Summary:  , studies in teleost brain have shown that adenosine A1 receptors appeared similar to that found in mammals... , A., 2003. Distribution and expression of A1 adenosine receptors, adenosine deaminase and ...

  

Source: Eizirik, Eduardo - Centro de Biologia Genômica e Molecular da Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul

 

Collection: Environmental Sciences and Ecology

 
69 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... the neuroprotective properties of A1 adenosine receptor analogues have been known for several years, the role of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
70 REVIEW ARTICLE Chemokine receptors and other G protein-coupled receptors
 

Summary:  D, Zhang L, et al. Heterologous expression of the adenosine A1 receptor in transgenic mouse retina... rhodopsin as well as adrenergic and adenosine receptors, provides molecular templates for how this diverse... of invertebrate rhodopsin, b1-adrenergic and ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
71 Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate
 

Summary:  protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate in urological... purinergic receptors are subdivided into ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
72 Prediction of the 3D structure of rat MrgA G protein-coupled receptor and identification of its binding site
 

Summary:  adenosine A1 receptor and 2A adrenergic receptor [39,40], making it unlikely to serve as the agonist binding... , Ijzerman A, Rivkees SA. Site-directed mutagenesis of the human A(1) adenosine receptor: ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
73 Although it has been known for more than half a century that extracellular purines, and specifically ATP, can affect
 

Summary:  of the TGF response. Pharmacological blockade of the adenosine A1 receptor inhibits, and A1 recep- tor... , to distinguish them from the adenosine-selective P1 receptors; a related class of receptors is ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
74 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165­205, 2004 Dopamine Receptor... The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling... properties that contribute to the definition of the receptor class, although some differences among ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
75 Cellular/Molecular Calcium Increases in Retinal Glial Cells Evoked by Light-
 

Summary:  converted to adenosine by ectoenzymes, resulting in the activation of ganglion cell A1 receptors... -induced calcium signalling by A1 and A2 adenosine receptors in cultured cortical astrocytes. Br J Pharmacol 141... ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
76 The Uroepithelial-associated sensory web , E Balestreire1
 

Summary:  family ErbB1­3 receptors,17 A1, A2a, A2b, and A3 adenosine receptors,18 a- and b-adrenergic receptors,19... , we observe that adenosine, most likely acting through A1 and A2a ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
77 Historical review: ATP as a neurotransmitter
 

Summary:  Transduction mechan- isms P1 (adenosine) A1 Brain, spinal cord, testis, heart, autonomic nerve terminals CCPA... to adenosine by ectoenzymes, so that some of the actions of ATP were directly on P2 receptors, whereas others... were due to the indirect action of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
78 Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety
 

Summary:  hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol 119:835­844. Valera S, Hussy N, Evans RJ, Adami... by activating group I P2X receptors. Diadenosine polyphosphates (ApnAs) and adenosine polyphospho guanosines... Interval EC50 Hill Coefficient M ATP ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
79 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  ]. Sympathetic nerves express inhibitory P2Y and P1 (A1) receptors indicating a P2 receptor-mediated negative... P2Y6 + NTPDase Ado Vasoconstriction Vasodilatation - - P1(A1) RBC ADVENTITIA CGRP SP ATP P2X P2Y ATP... hyperaemia via endothelial P2Y1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
80 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  . In addition, we predicted structures for the human A1, A2B, and A3 adenosine receptors (ARs) and used... ) to A1, A2A, A2B, and A3 human adenosine receptors. The computed energies show the same trends... subtypes ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science


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81 Pathophysiology and Therapeutic Potential of Purinergic Signaling
 

Summary:  subtypes of P1 receptors were cloned, namely, A1, A2A, A2B, and A3. In 1985, Burnstock and Kennedy proposed... in vasodilatation. P1(A1)-purinoceptors on nerve terminals of sympathetic and sensory nerves mediate adenosine... Y receptors in ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London; Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Biology and Medicine ; Geosciences

 
82 *MRC Laboratory of Molecular Biology,
 

Summary:  (100 µM) ATP + ACh 250 pA 1 s © 2001 Macmillan Magazines Ltd #12;170 | MARCH 2001 | VOLUME 2 www... properties of the receptors that detect ATP,and the fast actions of ATP in synapses. Fast and slow signalling... by ATP There are two main types of receptor for extracellular ATP (also called purinoceptors) ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
83 Immunobiology 209 (2005) 661668 Impairment of the splenic immune system in P2X2/P2X3 knockout mice
 

Summary:  isolated spleen mediated by adenosine A1-receptor activation. Br. J. Pharmacol. 109, 1059­1063. Han, C... , including bethanechol acting via muscarinic receptors (Wong, 1990) and NA acting via a1B receptors (Eltze... ; the ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
84 Editorial Manager(tm) for Nuclear Medicine Communications Manuscript Draft
 

Summary:  there are still controversies on how adenosine receptors (A1, A2A, A2B, and A3) mediate the cardioprotection... , it is generally accepted that the A1 adenosine receptor is the primary receptor. Activation ...

  

Source: Arizona, University of - Center for Gamma-Ray Imaging

 

Collection: Engineering ; Biology and Medicine

 
85 Purines and Sensory Nerves Geoffrey Burnstock
 

Summary:  of receptors for purines and pyrimidines are available, including four subtypes of P1 (adenosine), seven... and internalization of P2Y receptors in DRG neurons (Wang et al. 2006). Adenosine 50 -O-(3-thiotriphosphate) enhances... act on P2Y1, P2Y12 and P2Y13 receptors) or ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
86 List of publications LIST OF PUBLICATIONS
 

Summary:  E, Keijser JN, Nyakas C, Luiten PGM (2004) Ageing related decline in adenosine A1 receptor binding... acetylcholine receptor sensitivity. J Sleep Res 15(4):386-394. Van der Borght K, Ferrari F, Klauke K, Roman V... , Meerlo P (2005) Too little sleep gradually desensitizes the serotonin 1A ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
87 Nederlandse samenvatting NEDERLANDSE SAMENVATTING
 

Summary:  . Bijvoorbeeld de serotonine-1A en de adenosine A1 receptoren worden aan dezelfde G-eiwitten gekoppeld. In het... serotonine-1A receptor systeem het gevolg kan zijn van verhoogde adenosine afgifte tijdens het waken. De... natuurlijke antagonist van de adenosine ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
88 profound changes in both sleep (23) and the sleep EEG (24, 25), with a major decrease in
 

Summary:  by ectonucleotidases (16). Because there is a tonic level of extracellular adenosine that acts through the A1 receptor... mediated by A1 receptors. Because adenosine is implicated in the control of wake- to-sleep transitions ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
89 D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties*
 

Summary:  for heterodimerization has recently been provided for dopamine D1 and adenosine A1 receptors as well as for dopamine D2... receptor forms hetero-oligomers with the adenosine A1 receptor. As the issue of G ...

  

Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
90 Purinergic signalling in autonomic Alexander V. Gourine1
 

Summary:  ­1409 49 Gao, N. et al. (2007) Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal... - vation of P2Y receptors predominantly inhibits sympathetic transmitter release [11]. Inhibitory (A1... -protein-coupled P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
91 Enhancement of the surface expression of G protein-coupled receptors
 

Summary:  -terminus of the a1D-adrenoceptor (a1D-AR) dramatically enhanced expression of receptor binding sites [25] and plasma... impaired surface expression of these receptors in heterologous cells [26], suggesting that the a1D-AR N... ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
92 Nature Macmillan Publishers Ltd 1997 arterial blood sampling (0.5 ml samples) and
 

Summary:  , observed after blockade of peripheral adenosine receptors, and was not specific for caffeine. This find... reduction after antagonist with- drawal, suggests receptor-mediated regula- tion of the plasma adenosine... in the world1 , with actions mediated primarily by adenosine ...

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
93 Postnatal development of P2 receptors in the murine gastrointestinal tract
 

Summary:  further subdivided into A1, A2A, A2B and A3. P2 receptors have been divided into two families (Ab... ¼ adenosine, suggesting P2Y1 receptors. This was supported by the sensitivity of responses to 2-Me... equipotent suggesting a P2Y2 and/or P2Y4 receptor. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
94 Topology of Class A G Protein-Coupled Receptors: Insights Gained from Crystal Structures of Rhodopsins,
 

Summary:  receptor; ZM241385, 4-{2-[7-amino-2-(2-furyl)[1,2,4]triazolo-[2,3-a][1,3,5]triazin-5- ylamino... of Rhodopsins, Adrenergic and Adenosine Receptors Debarshi Mustafi and Krzysztof Palczewski Department... ., 2004), and strokes and cere- bral hypoperfusion (altered ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
95 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  :246­254. Vainio M, Törnquist K. 2000. The role of adenosine A1 receptors in the ATP-evoked Ca2+ response in rat... were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... , 1976a], and a basis for ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
96 Colocalization and Regulated Physical Association of Presynaptic Serotonin Transporters with A3 Adenosine
 

Summary:  Adenosine ReceptorsS Chong-Bin Zhu, Kathryn M. Lindler, Nicholas G. Campbell, James S. Sutcliffe, William A... ; accepted June 24, 2011 ABSTRACT Activation of A3 adenosine receptors (A3ARs) rapidly enhances the activity... -activated protein kinase; A3AR, A3 subtype adenosine ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine

 
97 International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors
 

Summary:  and Weetman, 1976), receptors for purines were subdivided into P1 (adenosine) and P2 (ATP and ADP) receptors... adenosine; CysLT, cyst- einyl leukotriene receptor; I B, inhibitor of nuclear factor (NF)- B; PMA, phorbol... ) or the activation of adenosine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
98 PHS 398/2590 (Rev 05/01) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle): Gerzanich, Vladimir
 

Summary:  : A novel approach to examine transmembrane topology of integral membrane proteins applied to the a1 subunit... of the nicotinic acetylcholine receptor. Biochemistry, 32:9975-9984. Peng, X., Katz, M., Gerzanich, V., Anand, R... ., and Lindstrom, J. (1994) Human _7 acetylcholine receptor: cloning of the _ 7 ...

  

Source: Weber, David J. - Department of Biochemistry and Molecular Biology, University of Maryland-Baltimore

 

Collection: Biology and Medicine

 
99 UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors
 

Summary:  . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... and in disease. For many years, it was recognised that adenosine, acting through P1 (usually A1) presynaptic... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
100 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Predicted structures of agonist and
 

Summary:  receptor activation, while the A1 and A3 adenosine sub- types are linked to Gi proteins inhibiting c... to Gq proteins.2 Thus activation of human adenosine A1 receptor (hAA1R), decreases the oxygen demand... Alignments of the ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science


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