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Sample search results for: abcg2 promoter demethylation

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1 Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric Dimers
 

Summary:  containing a T7 promoter. ABCG2-ABCG2 encodes two identical ABCG2 (R482G) proteins connected by a Sac... Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric... ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
2 Interaction with the 5D3 Monoclonal Antibody Is Regulated by Intramolecular Rearrangements but Not by Covalent
 

Summary:  but Not by Covalent Dimer Formation of the Human ABCG2 Multidrug Transporter* Received for publication,April 28, 2008... , 1113 Budapest, Hungary Human ABCG2 is a plasma membrane glycoprotein working as a homodimer or homo... monoclonal antibody shows a function-dependent reactivity to an extracellular ...

  

Source: Dokholyan, Nikolay V. - Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Physics ; Biology and Medicine

 
3 N-Linked Glycosylation of the Human ABC Transporter ABCG2 on Asparagine 596 Is Not Essential for Expression, Transport Activity, or Trafficking to the
 

Summary:  N-Linked Glycosylation of the Human ABC Transporter ABCG2 on Asparagine 596 Is Not Essential... ATP-binding cassette half-transporter ABCG2 is a 72 kDa plasma membrane protein that can confer... multidrug resistance to cells in culture when overexpressed. Both transiently and stably expressed ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
4 10.1110/ps.051998406Access the most recent version at doi: 2006 15: 1597-1607Protein Sci.
 

Summary:  in promoting conformational changes. Understanding how ABCG2 func- tions, how it adopts different conformations... but not substrate binding The nature of amino acid 482 of human ABCG2 affects substrate References http... .proteinscience.orgDownloaded from #12;The nature of amino acid 482 ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
5 Distinct population of hair cell progenitors can be isolated from the postnatal mouse cochlea using side population analysis
 

Summary:  cells, Abcg2 transporter, stem/progenitor cells, side population, SP- supporting cells ACKNOWLEDGEMENT... We thank Dr. T. Litman (University of Copenhagen) for the Abcg2 antiserum, Dr. H. Okano (Keio... identified in several tissues of mammals. The ATP-binding cassette transporter ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
6 A role for the elongator complex in zygotic paternal genome demethylation
 

Summary:  . Barreto, G. et al. Gadd45a promotes epigenetic gene activation by repair- mediated DNA demethylation... , G. P. GADD45A does not promote DNA demethylation. PLoS Genet. 4, e1000013 (2008). 17. Allen, M. D... LETTERS A role for the elongator complex in zygotic paternal genome demethylation ...

  

Source: Zhang, Yi - Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
7 The Plant Cell, Vol. 14, 117, November 2002, www.plantcell.org 2002 American Society of Plant Biologists Inducible DNA Demethylation Mediated by the Maize
 

Summary:  to the postreplicative, hemimethylated Spm sequence and promotes demethylation either by creating an appropriate... (Brunk et al., 1996; Kirillov et al., 1996). DNA demethylation in mammalian cells is promoted by trans... of TnpA using a glucocorticoid-inducible promoter. We show that ...

  

Source: Fedoroff, Nina V.- Huck Institutes of the Life Sciences & Department of Biology, Pennsylvania State University

 

Collection: Biology and Medicine

 
8 Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
 

Summary:  Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue... analogue, 9-(2-(phos- phonomethoxy)ethyl)-adenine (PMEA), and up-regulation of Abcg2 in some tissues... of the Mrp4 KO mouse prompted us to evaluate the possibility that ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
9 Eukaryotic chromatin contains a wealth of information required for the growth and development of a multi
 

Summary:  demethyl ation has also been reported to occur at the promoter of brainderived neurotrophic factor (BDNF)49... of the promoter49 . Because this event takes place in postmitotic neurons, active demethylation is thought... as TFF1) promoter exhibits periodic methylation and ...

  

Source: Zhang, Yi - Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
10 Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA
 

Summary:  Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain... C) hydroxy- lase TET1, by converting 5mCs to 5-hydroxymethyl- cytosines (5hmCs), promotes DNA demethylation... , demethylation of both exogenously introduced and endogenous 5hmCs is ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
11 Published on Web Date: October 21, 2010 r 2010 American Chemical Society 82 DOI: 10.1021/cn100078a |ACS Chem. Neurosci. (2011), 2, 8289
 

Summary:  -Glycoprotein Inhibitor Tariquidar Is Also a Substrate and an Inhibitor for Breast Cancer Resistance Protein (BCRP/ABCG2... P-gp, breast cancer resistance protein (BCRP, ABCG2), and multidrug resistance protein 1 (MRP1, ABCC... resistance protein (BCRP, encoded by the gene ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
12 10.1101/gad.1963010Access the most recent version at doi: 2010 24: 2107-2114Genes Dev.
 

Summary:  that demethylation of the promoters of certain pluripotency-associated genes, such as Oct4 and Nanog, is a requisite... -dependent demethylation clearly occurs at the promoters of silenced genes in heterokaryons in the absence of replication... -specific cofactors of AID that either ...

  

Source: Papavasiliou, F. Nina - Laboratory of Lymphocyte Biology, Rockefeller University

 

Collection: Biology and Medicine

 
13 DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase,
 

Summary:  the remethylation of a set of common genes. Finally, Gadd45 promoted demethylation and enhanced functional... -meC demethylation, whereby AID deaminates 5-meC, followed by thymine base excision by Mbd4, promoted... T cells a promoter-enhancer element of interleukin-2 gene undergoes ...

  

Source: Cairns, Brad - Huntsman Cancer Institute, University of Utah

 

Collection: Biology and Medicine

 
14 Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A
 

Summary:  Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P... by functioning as energy- dependent efflux pumps. The half-transporter ABCG2 and the widely studied P... of structurally unrelated chemotherapy agents from cells. In this study, we demonstrate that human ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
15 Characterization of the action of antipsychotic subtypes on valproate-
 

Summary:  . This remodeling might con- tribute to reelin- and GAD67-promoter demethylation and might reverse the GABAergic... . Histone deacetylase inhibitors acting on the histone code promote DNA demethylation in GABAergic neurons... conformation and marks DNA demethylation of specific ...

  

Source: Champagne, Frances A. - Department of Psychology, Columbia University

 

Collection: Biology and Medicine

 
16 DOI: 10.1126/science.1063443 , 1089 (2001);293Science
 

Summary:  demethylation events in differentiated tissues could then lead to fur- ther changes in gene expression as needed... are established in the ge- nome. Mechanisms for active demethylation have been suggested, but no enzymes have been... part of the genome is demethylated, and after some time remethylated, in a cell- or tissue

  

Source: Bergstrom, Carl T. - Department of Biology, University of Washington at Seattle

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
17 Published: April 13, 2011 r 2011 American Chemical Society 4300 dx.doi.org/10.1021/es103577e |Environ. Sci. Technol. 2011, 45, 43004306
 

Summary:  on methylation/demethylation. Aerobic conditions can promote demethylation of MMA and DMA to AsV . For example... MMA was demethylated to AsV in 30 days.1 However, anaerobic conditions can promote either methylation... disease related to atherosclero- sis, and DMA is known to be a ...

  

Source: Sparks, Donald L. - Department of Plant and Soil Sciences, University of Delaware

 

Collection: Environmental Management and Restoration Technologies

 
18 Pour obtenir le grade de DOCTEUR DE L'UNIVERSIT DE GRENOBLE
 

Summary:  flavonoïdes et de vérapamil comme ligands des transporteurs MRP1 et ABCG2 : De la conception à l... membranaires de type ABC, parmi lesquelles, MRP1 et ABCG2 sont largement impliquées. Ces transporteurs... , synthétisé et étudié des activateurs de MRP1 et des inhibiteurs ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
19 DOI: 10.1126/science.1211917 , 1229 (2011);333Science
 

Summary:  of nucleotides. Neither shows that caC is specifically pres- ent in promoters undergoing demethylation... at activated promoters for this model to gain acceptance as a bona fide mechanism of DNA demethylation... Demethylation This copy is for your personal, non-commercial use only. ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
20 MOLECULAR AND CELLULAR BIOLOGY, Oct. 2008, p. 61236133 Vol. 28, No. 19 0270-7306/08/$08.00 0 doi:10.1128/MCB.00233-08
 

Summary:  -specific demethylation associ- ated with the expressed heavy chain allele. Palindromic enhancers become demethylated... . Candidates include promoters that are locally associated with V and D segments and also with I regions... demethylation during B-cell develop- ment (14). A constitutively ...

  

Source: Skoultchi, Arthur - Department of Cell Biology, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine


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21 Preventing transcriptional gene silencing by active DNA demethylation Avnish Kapoora,b
 

Summary:  . Using chicken embryo nuclear extracts that can promote active demethylation, Jost and colleagues [93... of the transgene promoter but not gen- ome-wide demethylation was attributed to the physical associ- ation of the 5... hypermethylation and TGS by demethylating the target ...

  

Source: Zhu, Jian-Kang - Institute for Integrated Genome Biology, University of California at Riverside

 

Collection: Biotechnology

 
22 Genomic imprinting and methylation: epigenetic canalization and conflict
 

Summary:  . Specifically, I will focus on the mammalian methylation and demethylation activities in the preimplantation... , the methylation marks established in gametogenesis are subject to one of three fates: active demethylation... , passive demethylation or maintenance (Figure 1). Active demethylation involves the ...

  

Source: Wilkins, Jon F. - Santa Fe Institute

 

Collection: Biology and Medicine

 
23 This manuscript has been published in Proceedings of the National Academy of Sciences (2006) 103(30) : 11112-11117 Doi :10.1073/pnas.0601793103
 

Summary:  (30) : 11112-11117 Doi :10.1073/pnas.0601793103 Active cytosine demethylation triggered by a nuclear receptor... development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear... and controversial. Here, we present the first detailed characterization of the demethylation of an endogenous gene

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
24 The obesity-associated Fto gene is a transcriptional coactivator Qiong Wu a,1
 

Summary:  /EBPs) from unmethylated as well as methylation-inhibited gene promoters. Fto also exhibits nuclease activity... the DNA demethyl- ase AlkB (Escherichia coli) and ABH (mammalian AlkB homolog) genes, which are involved... in the repair of DNA alkylation damage [15­17]. FTO demethylates 3-methylthymine in vitro on single- stranded

  

Source: Toledo, University of - Center for Diabetes and Endocrine Research (CeDER)

 

Collection: Biology and Medicine

 
25 Role of the Arabidopsis DNA glycosylase lyase ROS1 in active DNA demethylation
 

Summary:  that can promote demethylation (12), a putative demethylase was puri- fied; this was found to be a G... active in demethylating the RD29A promoter. To rule out the possibility that the observed nicking... Role of the Arabidopsis DNA glycosylase lyase ROS1 in active DNA demethylation ...

  

Source: Zhu, Jian-Kang - Institute for Integrated Genome Biology, University of California at Riverside

 

Collection: Biotechnology

 
26 Regeneration Gaps Observations on Stem Cells and Cardiac Repair
 

Summary:  expressing the transport protein Abcg2 (so-called "side population"), which are low in c-kit (67) but have... population cells, and the authors show that the transport protein Abcg2 confers the side population cell... , et al. Persistent expression of the ATP-binding cassette transporter, ...

  

Source: Murry, Chuck - Center for Cardiovascular Biology & Department of Bioengineering, University of Washington at Seattle

 

Collection: Biology and Medicine

 
27 Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle.
 

Summary:  and rapid DNA demethylation is observed at the promoters of human Oct 4 and Nanog as early as day 1-2 post... to pluripotency gene transcription and demethylation of their promoters. These data demonstrated for the first... their differentiation and promote self-renewal in culture for ...

  

Source: Puglisi, Joseph - Department of Structural Biology, Stanford University

 

Collection: Biology and Medicine

 
28 DOI: 10.1126/science.1166859 , 1074 (2009);323Science
 

Summary:  DNA Demethylation and Adult Neuronal ActivityInduced Gadd45b Promotes www.sciencemag.org (this... ­Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis Dengke K. Ma,1,2 * Mi-Hyeon Jang,1... for activity-induced DNA demethylation of specific ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
29 siRNAs and DNA methylation: seedy epigenetics
 

Summary:  further studies described coordinated genome-wide DNA demethylation of TEs in the endosperm... demethylation and acti- vation of TEs in accessory cells of the gametophyte and seed reinforces silencing of TEs... endosperm respect- ively. The vegetative cell is critical for fertilization and the endosperm promotes

  

Source: Mosher, Rebecca - School of Plant Sciences, University of Arizona

 

Collection: Biology and Medicine

 
30 ANNUAL RESEARCH DAY PROGRAM DEPARTMENT OF PATHOLOGY AND LABORATORY
 

Summary:  function of the proteasome. Analyzing the occupancy of RAR- promoter by coactivators, coreppressors, RNA

  

Source: Xia, Xuhua - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
31 Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases
 

Summary:  - and polysaccharides for studies in chemistry, biology, and medicine. biocatalysis demethylation evolution P450... demethylation might provide a solution to both these problems. Although chemical removal of methyl groups... - ethylated monosaccharides, the challenging task of regioselec- tively demethylating these substrates ...

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collection: Chemistry ; Biology and Medicine

 
32 10081 How snakes slither 10086 Biodegradable fluorescent polymers
 

Summary:  , a painful condition result- ing from the buildup of urate. This genomic region contains the ABCG2 gene... , known to encode a multidrug transporter. Owen Woodward et al. conducted experiments that show that ABCG2... protein transports urate, and that the mutation encoded by this missense SNP in ...

  

Source: Yang, Jian - Department of Bioengineering, University of Texas at Arlington

 

Collection: Materials Science ; Engineering

 
33 Global COE International Symposium / Retreat 2010 Plenary Session at Main Hall, Convention Center
 

Summary:  Mizuno Association ofABCG2 polymorphism with pharmacokinetics and severe toxicityof sunitinib C-35 b Infection... promotes intestinal tumorigenesis through mTORC1 pathway activation in Apc716 mice" Teruaki Fujishita (GCOE... :50-11:10 R-5 "Latent TGF- Binding Protein 4 promotes elastic fiber assembly in vitro" ...

  

Source: Takada, Shoji - Department of Biophysics, Kyoto University

 

Collection: Chemistry ; Biotechnology

 
34 nature neurOSCIenCe advance online publication a r t I C l e S
 

Summary:  demethylation in a subset of neuronal gene promoters2,21­23 in the CNS argues for the presence of demethylation... effect of promoter demethylation as a consequence of Dnmt1 and Dnmt3a deficiency or to an indirect cause... found that DNA demethylation in this Stat1 ...

  

Source: Silva, Alcino - Department of Neurobiology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
35 Genomic imprinting in mammals was discovered in the early 1980s as a result of two types of mouse experi-
 

Summary:  demethylated after fertiliza- tion, and the paternal Snrpn promoter from becoming de novo methylated in sperm... ). In some instances, this has led to interest- methylation may spread from an IC into the promot- er... and apparently genome-wide demethylation in germ cells,which is completed by embryonic day ...

  

Source: Cooper, Robin L. - Department of Biology, University of Kentucky

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
36 Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat
 

Summary:  alter the epigenome at a glucocorticoid receptor gene promoter in the hippocampus of the offspring... receptor promoter. Central infusion of the adult offspring with the histone deacetylase inhibitor... nor- epinepherine, and glucocorticoids promote the develop- ment of a diverse range of high risk

  

Source: Champagne, Frances A. - Department of Psychology, Columbia University

 

Collection: Biology and Medicine

 
37 Current Biology 17, 5459, January 9, 2007 2007 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2006.10.059 The DNA Glycosylase/Lyase ROS1
 

Summary:  been shown to be required for demethylating a transgene promoter [1]. To deter- mine the function... glycosylase/lyase ROS1 partici- pates in active DNA demethylation by a base-excision pathway [1, 2]. ROS1 has... of ROS1 in demethylating endoge- nous loci, we carried out bisulfite-sequencing analysis of ...

  

Source: Zhu, Jian-Kang - Institute for Integrated Genome Biology, University of California at Riverside

 

Collection: Biotechnology

 
38 MOLECULAR AND CELLULAR BIOLOGY, Feb. 2004, p. 12701278 Vol. 24, No. 3 0270-7306/04/$08.00 0 DOI: 10.1128/MCB.24.3.12701278.2004
 

Summary:  Reserved. Continuous Zebularine Treatment Effectively Sustains Demethylation in Human Bladder Cancer Cells... and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions... gene expression and sustains demethylation of the 5 region for over 40 days, preventing remethylation

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
39 Targeted Disruption of the PME-1 Gene Causes Loss of Demethylated PP2A and Perinatal Lethality in Mice
 

Summary:  Targeted Disruption of the PME-1 Gene Causes Loss of Demethylated PP2A and Perinatal Lethality... complete loss of the demethylated form of PP2A in the nervous system and peripheral tissues. Interestingly... for the demethylated form of PP2A in maintenance of enzyme function and phosphorylation networks in vivo. Citation

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
40 MOLECULAR AND CELLULAR BIOLOGY, July 2007, p. 50555065 Vol. 27, No. 13 0270-7306/07/$08.00 0 doi:10.1128/MCB.00127-07
 

Summary:  is recruited to H3K4me3 to ensure a demethylated state at H3K36; (iv) Gcn5p acetylates H3K36 in the promoter... overexpression strains. In the knockout, H3K36 would fail to be demethylated at promoters, resulting... mammalian homolog, Jhd1-catalyzed histone demethylation requires iron ...

  

Source: Lieb, Jason - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine


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41 Applied Mathematics Letters 24 (2011) 12511256 Contents lists available at ScienceDirect
 

Summary:  factor NRF-2 which is known to promote the expression of ABCG2, ABCC1 and ABCC2 [13­16]. We thus propose... and ABCG2 [6]. d[CPTin] dt = kupCPT [CPTout ] - VeffCPT [ABC_CPT][CPTin] KeffCPT + [CPTin] - Vces... -modulated ABC transporter induction CPT11 exposure may enhance the expression ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine

 
42 2.5 m 2.5 m Supplementary Figure 1
 

Summary:  ,I243A,D244A) Jumonji-C: Histone Demethylation F-box: Protein Degradation Leucine Rich Repeats: Protein... -1105) JHDM1B(PHD);(C662A,C665A) JHDM1B(JmjC);(H242A,I243A,D244A) Jumonji-C: Histone Demethylation F... 30 kb 40 kb Transcribed PromoterNon-Transcribed 0 kb b rDNA Base Number rDNA Base Number 10 kb 20 kb

  

Source: Roth, David B. - Langone Medical Center, New York University

 

Collection: Biology and Medicine

 
43 Molecular Microbiology (2004) 51(3), 721728 doi:10.1046/j.1365-2958.2003.03796.x 2003 Blackwell Publishing Ltd
 

Summary:  , 2003513721728Original ArticleM. W. Bunn and G. W. OrdalUnregulated demethylation of B. subtilis McpB Accepted 26... causes methanol formation as a consequence of methylation and demethylation of conserved glutamate... -bound adapted receptor, the receptor must pass through a state of heightened susceptibility to demethylation

  

Source: Ordal, George W. - Department of Biochemistry, University of Illinois at Urbana-Champaign

 

Collection: Biology and Medicine

 
44 Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid
 

Summary:  in the following nine regions: SLC2A9 (p = 5.26102201 ), ABCG2 (p = 3.1610226 ), SLC17A1 (p = 3.0610214 ), SLC22A11... levels in women and the minor allele of rs2231142 in ABCG2 elevates uric acid levels more strongly in men... transporter (ABCG2). Based on screening ...

  

Source: Nyholt, Dale R. - Genetic Epidemiology Laboratory, Queensland Institute of Medical Research

 

Collection: Biology and Medicine

 
45 Maya Goldmit1 , Mark Schlissel2
 

Summary:  is always preceded by DNA demethylation and increased chro- matin accessibility. Using a model system... demethylation We have previously shown that the J region of the k gene is fully methylated on both alleles early... in lymphoid development, but undergoes demethylation at later stages (Mostoslavsky and Bergman, 1997

  

Source: Schlissel, Mark S. - Department of Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine

 
46 METHYLARSENIC SORPTION AND SPECIATION MECHANISMS IN NATURAL SYSTEMS
 

Summary:  structure (µ-XANES) spectra collected from As hotspots showed MMA and DMA were demethylated to AsV over 1... . As residence time increased more MMA was demethylated to AsV which was more strongly bound to the surface... by methylation/demethylation processes. The persistency of these compounds in the environment was longer than

  

Source: Sparks, Donald L. - Department of Plant and Soil Sciences, University of Delaware

 

Collection: Environmental Management and Restoration Technologies

 
47 DOI: 10.1126/science.1171609 , 1447 (2009);324Science
 

Summary:  Development Underlies Gene Extensive Demethylation of Repetitive Elements www.sciencemag.org (this information... .1170481 Extensive Demethylation of Repetitive Elements During Seed Development Underlies Gene Imprinting... are extensively demethylated in the endosperm. We discovered new imprinted genes by the identification

  

Source: Henikoff, Steven - Fred Hutchinson Cancer Research Center

 

Collection: Biology and Medicine ; Biotechnology

 
48 Received 20 March 2002 Accepted 5 June 2002
 

Summary:  : genomic imprinting; antisense; demethylation; evolutionarily stable strategy; IGF2R; modi er 1... , the padumnal allele is silenced indirectly by methylation of the madumnal promoter of a (padumnally expressed... promoter. At most padumnally silent loci, the straight- forward mechanism of repressing a padumnal ...

  

Source: Haig, David - Department of Organismic and Evolutionary Biology, Harvard University; Wilkins, Jon F. - Santa Fe Institute

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
49 Ecole Polytechnique Thse de doctorat
 

Summary:  .33 ABCF2 ABC28, HUSSY-18, M-ABC1 7q36ABCF/GCN20 ABCF3 3q27.1 ABCG1 ABC8, WHITE1 21q22.3 ABCG2 BCRP, BCRP1... Absence de péroxysomes ABCG2 Protoporphyrie érythropoïétique Photosensibilité aiguë ABCG5 Sitostérolémie... membres : ABCG1, ABCG2, ABCG4, ABCG5, et ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
50 MOLECULAR AND CELLULAR BIOLOGY, June 2007, p. 40584069 Vol. 27, No. 11 0270-7306/07/$08.00 0 doi:10.1128/MCB.02044-06
 

Summary:  methylation when PSA is activated. These studies suggested that Lsd1 demethylated H3K9 to promote activation... that SAPHIRE interacts with H3K4me2 regions but promotes H3K4 demethylation selectively at promoters... SAPHIRE deficient. SAPHIRE promotes activation, as ...

  

Source: Cairns, Brad - Huntsman Cancer Institute, University of Utah

 

Collection: Biology and Medicine

 
51 Reversal of Histone Lysine Trimethylation by the JMJD2
 

Summary:  methylases and demethylases such as LSD1 and JHDM1, which mediate demethylation of di- and monomethylated his... transcribed genes (reviewed in Martin and Zhang [2005]). In contrast, H3-K9 promoter methylation is Cell 125... with the androgen receptor, LSD1 has also been shown to demethylate H3-K9Me2, expanding the substrate ...

  

Source: Colaiacovo, Monica - Department of Genetics, Harvard University; Smolikov, Sarit - Department of Biology, University of Iowa

 

Collection: Biology and Medicine

 
52 Environmental epigenetics and allergic diseases: recent advances J. S. Kuriakose and R. L. Miller
 

Summary:  -g promoter displays a high level of methylation in nai¨ve CD4 T lymphocytes, but becomes demethylated with Th... that short-term PM10 exposure may be associated with DNA demethylation of the iNOS promoter, and long- term... ]. This characterization of the unique FoxP3 promoter ...

  

Source: Columbia University, Department of Environmental Health Sciences, Columbia Center for Children’s Environmental Health

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
53 CLASS 3.5: 03/29/07 EUKARYOTIC TRANSCRIPTION I
 

Summary:  considerations - Recall that methylation of DNA - Methylation close to promoter - Demethylation would be required... 1 CLASS 3.5: 03/29/07 EUKARYOTIC TRANSCRIPTION I: PROMOTERS AND ENHANCERS A. Promoters... b. Prokaryotic promoters - Recall that RNA pol binds - May need ancillary factors ...

  

Source: Andres, Andrew - School of Life Sciences, University of Nevada at Las Vegas

 

Collection: Biology and Medicine

 
54 Cell Research | Vol 20 No 3 | March 2010 A H3K4 demethylase and its demethylase-independent repression function
 

Summary:  E, Wissmann M, Yin N, et al. LSD1 demethylates repressive histone marks to promote androgen... and has been shown to demethylate mono- and di-methyl K4 of histone H3 (H3K4me1 and H3K4me2) as well... but is also required for LSD1 to demethylate nucleosomal sub- strates [6]. Interaction with liganded androgen

  

Source: Zhang, Yi - Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
55 Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
 

Summary:  , the transcriptional silencing of tumor suppressor genes by CpG island promoter hypermethylation has emerged... INK4a, has been tightly linked to the presence of CpG island promoter hypermethylation (8­10), we... . In this regard, restoration of miRNA-127 expression in cancer cells by treatment with a DNA-demethylating agent

  

Source: Miska, Eric - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collection: Biology and Medicine

 
56 TOXICOLOGICAL SCIENCES 102(1), 7681 (2008) doi:10.1093/toxsci/kfm290
 

Summary:  that demethylation of sites at the proximal promoter and conserved intronic regulatory element (CIRE) in the first... inhaled exposure to DEP would induce hypermethylation of the IFN-c gene promoter, and demethylation... . fumigatus sensitization induced demethylation in only one of the ...

  

Source: Columbia University, Department of Environmental Health Sciences, Columbia Center for Children’s Environmental Health

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
57 N d'ordre : 270-2007 Anne 2007 prsente devant
 

Summary:  -P.................................................................... 28 2.6. Le transporteur ABCG2... .................................................................................... 29 2.6.3. Fonction d'ABCG2 dans les cellules souches... ............................................... 31 2.6.5. ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
58 Molecular Cell Short Article
 

Summary:  function on p53, which promotes apoptosis. LSD1-mediated demethylation is required for DNA damage... -binding activity, association with the coactivator p53BP1, or increase of p53 protein stability. Set9 promotes cell... by an unknown enzyme, which promotes association with the coactivator p53BP1 (Huang et ...

  

Source: Hardy, Christopher R. - Biology Department, Millersville University

 

Collection: Environmental Sciences and Ecology

 
59 GEOC Sunday, March 21, 2010 48 -Methylarsenate distribution and speciation in soil
 

Summary:  was associated with iron and that sorbed MMA and DMA were demethylated to arsenate over time... with the demethylation rate of DMA being faster than for MMA. Sunday, March 21, 2010 04:20 PM Future Prospects

  

Source: Sparks, Donald L. - Department of Plant and Soil Sciences, University of Delaware

 

Collection: Environmental Management and Restoration Technologies

 
60 Identification of putative Arabidopsis DEMETER target genes by GeneChip analysis
 

Summary:  of DNA demethylation. Ó 2007 Elsevier Inc. All rights reserved. Keywords: Gene imprinting; DNA... demethylation; DNA glycosylase; GeneChip analysis Double fertilization is a unique characteristic of flower- ing... . Demethylation by the DEMETER (DME) DNA glycosylase activates expression of the maternal MEA allele [8

  

Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine


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61 Published: April 13, 2011 r 2011 American Chemical Society 4293 dx.doi.org/10.1021/es103576p |Environ. Sci. Technol. 2011, 45, 42934299
 

Summary:  due to the weaker sorption affinity for DMA that can promote more demethylation by microbes.34... organisms in the environment.1 MMA and DMA are also demethy- lated to AsV or AsIII . Methylation/demethylation... reported.3 The factors affecting methyla- tion/demethylation seem to be redox potential as well ...

  

Source: Sparks, Donald L. - Department of Plant and Soil Sciences, University of Delaware

 

Collection: Environmental Management and Restoration Technologies

 
62 CTMI (2006) 301:283315 c Springer-Verlag Berlin Heidelberg 2006
 

Summary:  . . . . . . . . . . . . . . . 302 6 Potential Role of Deamination and Glycosylases in Demethylation . . . . . 303 6.1 Demethylation... via Direct Excision of Methylcytosines by Glycosylases . . . 304 6.2 Accelerated Demethylation... such as Aid and Apobec in accelerating deamination of methylcytosine and consequent DNA ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
63 CheB is required for behavioural responses to negative stimuli during chemotaxis in Bacillus subtilis
 

Summary:  assay, as observed previously in response to azetidine-2-carboxylate. Furthermore, net demethylation... of McpB is logarithmically depen- dent on asparagine concentration, with half-maximal demethylation... . Ordal, unpublished), which thereby becomes activated to demethylate the MCPs and produce methanol

  

Source: Ordal, George W. - Department of Biochemistry, University of Illinois at Urbana-Champaign

 

Collection: Biology and Medicine

 
64 Toxicology Letters 120 (2001) 161164 Gene imprinting in developmental toxicology: a possible
 

Summary:  in the tumorigenic process as a sec- ondary stimulus or promoter. This is, to a large extent, due to the fact... of gene expression in a cell is the methylation or demethylation of the gene's regu- latory elements. 3... . Effects of diethylstilbestrol (DES) Thus, we have studied the methylation pattern of the promoter

  

Source: McLachlan, John - Environmental Endocrinology Laboratory, Tulane University

 

Collection: Environmental Sciences and Ecology

 
65 Systems Biology 7.32 / 7.81 / 8.591 Problem Set 3 Assigned: 10.21.09
 

Summary:  assumed the following: for both (A) and (B), the X promoter is inactivated by the binding of a single... molecule of Y, and the Y promoter is activated by the binding of a single molecule of X. In addition... , for (B), the X promoter is activated by the cooperative binding of two molecules of X. The various

  

Source: van Oudenaarden, Alexander - Department of Physics, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine ; Physics

 
66 Synthesis and Characterization of N-Demethylated Metabolites of Malachite Green and Leucomalachite
 

Summary:  Synthesis and Characterization of N-Demethylated Metabolites of Malachite Green and Leucomalachite... , undergoes sequential oxidation to produce various N-demethylated derivatives (monodes-, dides(sym)-, dides... , and their N-demethylated metabolites. The synthesis involves a coupling of 4-(dimethylamino)- benzophenone

  

Source: Cho, Bongsup P. - Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island

 

Collection: Biology and Medicine

 
67 Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
 

Summary:  by transcriptional silencing associated with CpG island-promoter hypermethylation. We also show that... . The described phenotype is reversed by the use of a DNA-demethylating agent or by the reintroduction of WRN... in sporadic neoplasms. Transcriptional inactivation by CpG island promoter hypermeth- ylation

  

Source: Bergstrom, Carl T. - Department of Biology, University of Washington at Seattle

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
68 Since the discovery of the first histone lysine demethylase in 2004, two protein families with numerous members have been
 

Summary:  with numerous members have been identified that demethylate various histone lysine residues. Initial studies... identified. The existence of enzymes that methylate or demethylate histone lysines is perhaps unsurprising... demethylase. LSD1/KDM1 demethylates both di- and mono- methylated K4 (H3K4me2/1) (Shi et al., 2004). In 2006

  

Source: Colaiacovo, Monica - Department of Genetics, Harvard University

 

Collection: Biology and Medicine

 
69 Genetic Variation in the Proximal Promoter of ABC and SLC Superfamilies: Liver and Kidney Specific Expression
 

Summary:  , Poonkuzhali et al described novel SNPs in the ABCG2 promoter region (-15994C.T (rs7699188), -56846A... .C, and -15622C.T) that were significantly associated with ABCG2 expression in lymphoblast, liver and... Genetic Variation in the Proximal Promoter of ABC and SLC ...

  

Source: 

 

Collection: Biology and Medicine ; Biotechnology

 
70 JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation
 

Summary:  the transcription of ribosomal RNA by binding to the rDNA promoter and demethylating H3K36me1/2, and that its... DNA promoter region (Figure 5A and B), suggesting that a JmjC-domain enzyme demethylating H3K4me3 on the r... as a regulator of ribosome biogenesis. KDM2A controls ...

  

Source: Zhang, Yi - Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
71 JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes
 

Summary:  by JHDM1B is dependent on its JmjC domain, which is necessary for the specific demethylation... dehydrogenase (GAPDH) promoter and by the fact that a DNA-binding mutant, JHDM1B(CXXC), failed to bind to the 8... the requirement for the JmjC domain, we addressed previous studies showing that JHDM1A demethylates dimethylated

  

Source: Roth, David B. - Langone Medical Center, New York University

 

Collection: Biology and Medicine

 
72 DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism
 

Summary:  but to a lesser extent (Supplemental Figure). 3.2. sEH promoter demethylation increases the expression of s... EH To determine the methylation status of the sEH promoter region and the change in activity after demethylation... (-62-~-56 bp) TSS+1 bp +58bp +70bp Fig. 3. 5-Aza-CdR ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
73 Hindawi Publishing Corporation PPAR Research
 

Summary:  specifically affects the expression of "stemness" genes, including ABCG2, Egfr, and CD44. Our data indicate... . Gene symbol Probe IDa FCb Gene Description Biological Processc Abcg2 1422906 at -3.1 ATP... . These entities include ATP-binding cassette g2 (Abcg2), cell ...

  

Source: Toledo, University of - Center for Diabetes and Endocrine Research (CeDER)

 

Collection: Biology and Medicine

 
74 Robust perfect adaptation in bacterial chemotaxis through integral feedback control
 

Summary:  increases CheA activity, promoting CheY phosphorylation. The methylation state of the receptor is balanced... by the demethylation enzyme CheB. CheZ acts to dephosphorylate CheY-P (6). The dynamics of receptor meth- ylation... the demethylation rate bA, which is propor- tional to the receptor complex activity A (assumptions 1 ...

  

Source: Doyle, John - Department of Electrical Engineering, California Institute of Technology

 

Collection: Engineering

 
75 The cloning of animals from adult cells has demonstrated that the developmental state of adult cells can be reprogrammed
 

Summary:  of differentiation genes by Polycomb proteins; Promoter hypomethylation Global DNA demethylation X inactivation... as DNA demethylation of the promoter regions of Oct4 and Nanog and, in female cells, the reactivation... inactivation; Repression of lineage-specific genes by Polycomb proteins; ...

  

Source: Devoto, Stephen H. - Biology Department, Wesleyan University

 

Collection: Environmental Sciences and Ecology

 
76 The EMBO Journal vol.4 no.5 pp.1301-1306, 1985 The promoter of the late plO gene in the insect nuclear poly-
 

Summary:  The EMBO Journal vol.4 no.5 pp.1301-1306, 1985 The promoter of the late plO gene in the insect... promoters conform to those of other eukaryotic pro- moters and are rich in AT base pairs. We used the p... the function ofthe plO gene promoter in insect and mammalian cells. Upon transfection of the p

  

Source: Lübbert, Hermann - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
77 Promoter CpG Methylation of Hox-a10 and Hox-a11 in Mouse Uterus Not Altered Upon
 

Summary:  . Yokomori N, Moore R, Negishi M. Sexually dimorphic DNA demethylation in the promoter of the Slp (sex... Promoter CpG Methylation of Hox-a10 and Hox-a11 in Mouse Uterus Not Altered Upon Neonatal... permanently alter uterine lactoferrin gene expression through modulation of the lactoferrin promoter

  

Source: McLachlan, John - Environmental Endocrinology Laboratory, Tulane University

 

Collection: Environmental Sciences and Ecology

 
78 Copyright 01990 by the Genetics Society of America DNA Methylation in Eukaryotes: Kinetics of Demethylation and de Novo
 

Summary:  of Demethylation and de Novo Methylation During the Life Cycle Sarah P. Otto and Virginia Walbot Department... and demethylation of eukaryotic DNA; the model incorporates values for de novo methylation and the error rate... are newly methylated equals the proportion of sites which become demethylated in a cell generation

  

Source: Otto, Sarah - Department of Zoology, University of British Columbia

 

Collection: Environmental Sciences and Ecology

 
79 Crystal structure of the FTO protein reveals basis for its substrate specificity
 

Summary:  ABH1 (also known as ALKBH1)11 and ABH3 (ALKBH3)12­14 share the ability to demethylate 1-methyladenine... hydrogen bond with the O4-3-meT, resulted in no detectable FTO activity of demethylating 3-meT (Fig. 4e... , such a positioning of 1-meG in FTO, as mentioned earlier, would generate steric clashes with Arg 96, thus promoting

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
80 [Epigenetics 4:3, 144-149; 1 April 2009]; 2009 Landes Bioscience 144 Epigenetics 2009; Vol. 4 Issue 3
 

Summary:  promoter methylation patterns. The concept of demethylation in the regula- tion of neuronal gene expression... , Grayson DR, Costa E. Demethylation of reelin and glutamic acid decarboxylase67 brain promoters is induced... of multiple promoters expressed in neurons that may be modulated ...

  

Source: Champagne, Frances A. - Department of Psychology, Columbia University

 

Collection: Biology and Medicine


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81 SI Appendix 1. Inferring cellular response from noise measurements in bacterial chemotaxis
 

Summary:  ) 4.2. Coarse-grain models of the methylation demethylation reactions 5. Distribution of [Che... sometimes promote phenotype variability within an isogenic population of cells (1-6). The significance... the (de)methylations reactions and therefore operate at quasi-equilibrium on the time scales relevant

  

Source: Cluzel, Philippe - Department of Molecular and Cellular Biology, Harvard University; Emonet, Thierry - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Biology and Medicine ; Physics

 
82 Eur J Cancer. Author manuscript Methylation-associated PHOX2B gene silencing is a rare event in human
 

Summary:  for expression, mutations of coding and promoter sequences, loss of heterozygosity (LOH), or aberrant... of the cases and aberrant CpG dinucleotide methylation of the 500 bp PHOX2B promoter% region in 4/31 tumours... mutation, a second-step methylation of the DNA promoter, if present, occurs12 13 exclusively on the wild

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
83 Cancer Cell AndrogenReceptorGeneExpressioninProstateCancer
 

Summary:  -specific demethylase 1 (LSD1) and H3K4me1,2 demethylation. AR similarly represses expression of multiple genes... markedly increased expression of transiently trans- fected Flag-tagged AR regulated by a CMV promoter... three sites linked to the AR gene: ARBS1 in the promoter region (10% FDR), ARBS2 in intron 2 (5% FDR

  

Source: Liu, Xiaole Shirley - Dana-Farber Cancer Institute & Department of Biostatistics, Harvard University

 

Collection: Computer Technologies and Information Sciences ; Biotechnology ; Biology and Medicine

 
84 JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer
 

Summary:  demonstrated that JARID1B directly catalyzes the demethylation. The enzymatic activity requires the JmjC domain... -regulated in prostate cancer. demethylation methylation transcription JmjC domain Histone methylation plays an important... of the identified histone demethylases, LSD1 and JHDM2A, were shown to promote androgen ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
85 Histone Deacetylase-Dependent Establishment and Maintenance of Broad Low-Level Histone Acetylation within a Tissue-Specific Chromatin Domain
 

Summary:  to induce demethylation of a promoter within a transiently transfected cytomegalovirus-enhanced green fluo... deacetylase (HDAC) inhibitors induce H4 acetylation at the Ey promoter [Forsberg, E. C., Downs, K. M... to the promoter or to the entire subdomain. We show that the HDAC inhibitor trichostatin A ...

  

Source: Bresnick, Emery H. - Molecular and Cellular Pharmacology Training Program & Department of Pharmacology, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
86 2006LANDESBIOSCIENCE.DONOTDISTRIBUTE. [Epigenetics 1:4, 155-162, October/November/December 2006]; 2006 Landes Bioscience
 

Summary:  ; and text below), supporting the hypothesis that LEP promoter demethylation may occur in adipose tissue... sperm suggest that the LEP promoter becomes reprogrammed by demethylation during male gametogenesis... demethylation modulates mouse leptin promoter activity ...

  

Source: Laird, Charles - Department of Biology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
87 Nature Macmillan Publishers Ltd 1997 Robustness in simple
 

Summary:  B demethylates it. A feedback mechanism is achieved through the CheA-mediated phosphorylation of CheB, which... enhances its demethylation activity. b, Mechanism for robust adaptation. E is transformed to a modified... ¡ The presence of am in the equation is due the fact that CheB demethylates only the active receptors; we ...

  

Source: Timmer, Jens - Freiburger Zentrum für Datenanalyse und Modellbildung & Physikalisches Institut, Albert-Ludwigs-Universität Freiburg

 

Collection: Physics

 
88 Nature Macmillan Publishers Ltd 1997 Robustness in simple
 

Summary:  B demethylates it. A feedback mechanism is achieved through the CheA-mediated phosphorylation of CheB, which... enhances its demethylation activity. b, Mechanism for robust adaptation. E is transformed to a modified... 1 The presence of am in the equation is due the fact that CheB demethylates only the active

  

Source: Barkai, Naama - Departments of Molecular Genetics & Physics of Complex Systems, Weizmann Institute of Science

 

Collection: Biotechnology

 
89 Epigenetic control of plant development by Polycomb-group Daniel Schubert, Oliver Clarenz and Justin Goodrich
 

Summary:  Histone demethylation? At4 g16310 ? ? LSD11 Histone demethylation? REF6 Day-length-independent promotion... downstream of the promoter) are functionally important in controlling gene expression. Nonetheless, several... that promote meristem identity. In an earlier study, in which FIE ...

  

Source: Goodrich, Justin - Institute of Molecular Plant Sciences, University of Edinburgh

 

Collection: Biology and Medicine

 
90 drug discovery drug discovery
 

Summary:  cells. In fact, preliminary evidence supports this hypothesis. · Development of strategies to promote... is in prostate and colon cancer. We are examining the role of inflammation as a tumor promoter, and we... . Such translocations are often indicative of growth promoting signals in tumor cells. · Compounds with novel ...

  

Source: Purdue University, Department of Forestry and Natural Resources, Human-Environment Modeling and Analysis Laboratory

 

Collection: Environmental Sciences and Ecology

 
91 Comparison of [11 C]-(R)-PK 11195 and [11
 

Summary:  called P-glycoprotein), H460 and H460/ MX20 (ABCG2), and MCF-7 and MCF-7/VP16 (ABCC1). Cells were... at the blood­brain barrier: ABCB1 (P-glycoprotein), ABCC1, and ABCG2. Substrate specificity was determined... pair selectively overexpressed ABCB1, ABCC1, or ABCG2. ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
92 SAR and QSAR in Environmental Research Vol. 19, Nos. 12, JanuaryMarch 2008, 5570
 

Summary:  ; demethylation inhibitors; multidrug resistance; exploratory analysis; partial least squares; green mould 1... ://www.informaworld.com #12;belong to Class 1 inhibitors or demethylation inhibitors (DMIs) class of sterol biosynthesis... /Tni Genome descriptors of fungal strains PCR Length of the promoter fragment in the PdCYP51 gene ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
93 Allelic `choice' governs somatic hypermutation in vivo at the immunoglobulin j-chain locus
 

Summary:  Bergman1 Monoallelic demethylation and rearrangement control allelic exclusion of the immunoglobulin j... underwent monoallelic demethylation at the Igk locus, and the demethylated allele was the `preferred... , demethylation4 and rearrangement on the early replicating allele1. After the actual recombination ...

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collection: Biology and Medicine

 
94 Polar Biol (2009) 32:751758 DOI 10.1007/s00300-008-0578-x
 

Summary:  to no demethylation or ring hydroxyl- ation. The exposure of these ancient woods to the young soils, where woody... of the number of free hydroxyls on the lignin structure, thereby assessing micro- bial or chemical demethylation... that the increase in this ratio can be promoted by chemical condensation processes or loss of side ...

  

Source: Blanchette, Robert A. - Department of Plant Pathology, University of Minnesota

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
95 let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
 

Summary:  to chemotherapy, in part from overexpressing an ATP-binding cassette half- transporter ABCG2 (Patrawala et al... , but not differentiated SK-3rd or SKBR3, stained for ABCG2 by immunoblot (Figure S4). Reduced ABCG2 was not a di- rect... -unexposed mammospheric SKBR3. ...

  

Source: Lieberman, Judy - Immune Disease Institute, Harvard University

 

Collection: Biology and Medicine

 
96 Immunity 24, 369379, April 2006 2006 Elsevier Inc. DOI 10.1016/j.immuni.2006.03.007 ReviewT Helper Cell Differentiation
 

Summary:  acetylation and DNA demethylation, demarcating cis elements or areas of transcriptional activity. Depicted... in this figure are hypersensitive sites and sites of histone H3 hyperacetylation and DNA demethylation... enhancement of IL-4 promoter activity (Lee et al., 2001). HS1/CS1/CGRE is located 1.6 kb upstream of Il13

  

Source: Spilianakis, Charalampos G. "Babis" - Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology, Hellas

 

Collection: Biology and Medicine

 
97 Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
 

Summary:  T-DMR of the Nanog promoter is demethylated in ES cells, and its methylation correlates with Nanog... that DNA demethylation may be a Tet1-mediated process6 . Here we extend this study by demonstrating... promoter, supporting a role for Tet1 in regulating DNA methylation status. Furthermore, knockdown of ...

  

Source: Zhang, Yi - Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
98 Metaphase chromosome condensation is a dynamic process that must utilize cis elements to form and maintain the final
 

Summary:  accessibility of T7 RNA polymerase to a promoter located 1 kb from the enhancer and regional demethylation... 7 promoter. 29. Lichtenstein M, Keini G, Cedar H, Bergman Y: B cell-specific demethylation: a novel... Figure 3 W + W m4 W m4 + MATH-20 SAR Enhancer T3 local (T3) 1 kb T7 distant (T7) Regional ...

  

Source: Hart, Craig M. - Department of Biological Sciences, Louisiana State University

 

Collection: Biology and Medicine

 
99 bined alleles also targets the rearranged anti-body genes for further mutation, and that this
 

Summary:  Beroe ovata, which preys on M. leidyi, may promote the recovery of the next highest trophic layer... in a given cell, in part through the selective acquisition of epigenetic marking by demethylation... than only one, were expressed, yet demethylation and extensive hyper- mutation were confined to just

  

Source: Fraden, Seth - School of Physics, Brandeis University

 

Collection: Physics ; Materials Science

 
100 Comparison of [11 C]-(R)-PK 11195 and [11
 

Summary:  called P-glycoprotein), H460 and H460/ MX20 (ABCG2), and MCF-7 and MCF-7/VP16 (ABCC1). Cells were... at the blood­brain barrier: ABCB1 (P-glycoprotein), ABCC1, and ABCG2. Substrate specificity was determined... pair selectively overexpressed ABCB1, ABCC1, or ABCG2. ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; McMahon, Francis - Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health

 

Collection: Biology and Medicine


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