Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Topic List  Advanced Search  
Sample search results for: aav retinal transduction

Page:   2  3  4  5 
 
1 JOURNAL OF VIROLOGY, Aug. 2002, p. 76517660 Vol. 76, No. 15 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.15.76517660.2002
 

Summary:  capsids (AAV2/5) showed variable retinal pigmented epithelium (RPE) and photoreceptor cell transduction... /6 showed only RPE transduction at 5 and 15 weeks, while AAV2/3 did not transduce retinal cells. We conclude... Gene therapy vectors based on adeno-associated ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
2 Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display
 

Summary:  the tropism and transduction frequency in the central nervous system (CNS) of three different rAAV vector... transduction frequencies than rAAV2/2 in all regions injected, although the differences were marginal in some... of the hippocampus (HPC) have remained refractory to AAV2 ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison; Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
3 original article 2096 www.moleculartherapy.org vol. 17 no. 12, 20962102 dec. 2009
 

Summary:  retinal transduction from the vitreous. It has been shown that after intravitreal injection, the AAV... transduction profile of retinal cells differs significantly between neonatal and adult rats.15 Injection of AAV... Limiting Membrane Barriers to ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
4 Current Gene Therapy, 2003, 3, 281-304 281 1566-5232/03 $41.00+.00 2003 Bentham Science Publishers Ltd.
 

Summary:  also be relevant in vivo. Consequently, these individuals might be resistant to transduction with AAV-2... ... This chapter will describe recently published analyses of tropism and transduction characteristics of AAV... of AAV vectors allowed efficient targeting of specific ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
5 original article 2088 www.moleculartherapy.org vol. 17 no. 12, 20882095 dec. 2009
 

Summary:  (AAV) vectors, leads to predomi- nant transduction of neurons and epithelia within the central nervous... capable of efficient glia transduction by employing directed evolution with a panel of four distinct AAV... and retinal neovascular disease. To date, the use of viral vectors ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
6 A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Muller Cells
 

Summary:  into macaque eyes showed that AAV is still able to overcome this challenge and lead to retinal transduction [23... R, et al. (2009) Inner limiting membrane barriers to AAV mediated retinal transduction from... significantly improved transduction ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
7 Expert Review Designer Gene Delivery Vectors: Molecular Engineering and Evolution
 

Summary:  transduction efficiency (Fig. 1). Isolation of Novel AAV Serotypes and Pseudotyping The majority of capsid... -specific transduction, whereas AAV2 vector (AAV2/2) showed transduction biased to neurons in the central nervous system... , with the ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
8 Virus Research 104 (2004) 5159 Novel approaches to augment adeno-associated virus
 

Summary:  -limiting steps in rAAV type-2 (rAAV-2) transduction. Several strategies have been developed to enhance rAAV-2... transduction by enhancing endocytosis of rAAV-2. A selective trypsinization assay demonstrated... of a dominant negative mutant of Rac1 (N17Rac1) ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
9 Gene Therapy (1999) 6, 14271437 1999 Stockton Press All rights reserved 0969-7128/99 $12.00
 

Summary:  damage including UV, hyd- of rAAV transduction. Furthermore, using electron spin res- roxyurea... /or activation of cellular factors important in the inhibits the augmentation of rAAV transduction following... in rAAV rently unknown. We hypothesized that reactive oxygen ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
10 Introduction Cystic fibrosis (CF) is the most common inherited dis-
 

Summary:  -associated virus­2 (AAV-2) receptors or coreceptors at these sites. The dramatically lower transduction efficiency... capsid proteins interferes with rAAV-2 transduction and provides new approaches to cir- cumvent... the effect of different chemicals on the efficiency of AAV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
11 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  ). Following transduction, rAAV genomes can persist as episomes (1, 6, 9), or, alternatively, they can... of transduction and persistence. Although trans- duction of rAAV has been demonstrated in vitro in cell culture... -mediated transduction remain unclear. The integration of wild-type ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
12 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  in efficiency of transduction to various tis- sues exist for rAAV. For example, rAAV-mediated gene trans- fer... that the abundance of the AAV type 2 (AAV-2) receptor and coreceptors may be at the heart of differing transduction... -1, and V 5 integrin may occur from ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
13 HUMAN GENE THERAPY 16:781791 (July 2005) Mary Ann Liebert, Inc.
 

Summary:  al., 2001; Xu et al., 2003). rAAV2 transduction in the hippocampus has been preferentially observed... 5 transduce retinal pigment epithelium (RPE) and photoreceptor cells, with higher transduction... ) (see Fig. 1). rAAV2 transduction of the hippocampus is limited to ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
14 original article 2114 www.moleculartherapy.org vol.15no.12,21142123dec.2007
 

Summary:  Society of Gene Therapy Biological Differences in rAAV Transduction of Airway Epithelia in Humans... to assessing the biology of rAAV-mediated transduction for three serotypes, we characterized the bioelectric... + and Cl- transport properties. In contrast, rAAV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
15 Systemic but Not Intraocular Epo Gene Transfer Protects the Retina from Light-and
 

Summary:  , AAV, apoptosis, animal models INTRODUCTION Retinitis pigmentosa (RP) is a group of inherited (Mende... models of retinal degeneration we delivered AAV vectors encoding Epo to the retinas and compared... in animals before phototoxicity: sub- retinal injections with ...

  

Source: Sandini, Giulio - Dipartimento di Informatica Sistemistica e Telematica, Università degli Studi di Genova

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
16 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  , the transduction efficiency of rAAV appears to vary greatly among different tissues. In part, the lack of AAV-2... types (16). The nuclear events influencing rAAV transduction, such as the phosphorylation status... /Accepted 14 July 2000 Adeno-associated virus (AAV) ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
17 SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret,
 

Summary:  SHORT COMMUNICATION Comparative biology of rAAV transduction in ferret, pig and human airway... the transduction biology of three rAAV serotypes (AAV1, 2 and 5) in human, ferret, pig and mouse-polarized airway... epithelia. Our results indicate that apical ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
18 Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia*
 

Summary:  Unique Biologic Properties of Recombinant AAV1 Transduction in Polarized Human Airway Epithelia... . In the present study, we sought to compare the biologic properties of rAAV2/1, rAAV2/2, and rAAV2/5 transduction... method. Results demonstrated that apical ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
19 A Two-hybrid Screen Identifies Cathepsins B and L as Uncoating Factors for Adeno-associated Virus 2
 

Summary:  in vivo. To further unravel the mechan- isms behind AAV8 transduction, we used yeast two- hybrid analyses... are essential for efficient AAV2- and AAV8-mediated transduction of mammalian cells, and document the ability... the mechanisms behind transduction by ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
20 JOURNAL OF VIROLOGY, 0022-538X/98/$04.00 0
 

Summary:  FIG. 2. Formation of rAAV head-to-tail circular intermediates following in vivo transduction of muscle... that these structures represent stable episomal forms following rAAV transduction in muscle. Stability of cir- cular... in the application of rAAV, the mechanisms of in vivo ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine


Page:   2  3  4  5 
Page:   1  2  3  4  5 
 
21 JOURNAL OF VIROLOGY, Oct. 2006, p. 98319836 Vol. 80, No. 19 0022-538X/06/$08.00 0 doi:10.1128/JVI.00878-06
 

Summary:  the processes behind AAV8 transduction is important for its application and optimal use in human gene therapy... contribution to AAV8 transduction of cultured cells and mouse liver in vivo. We also show that LamR plays... a role in transduction by three other closely related serotypes ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
22 original article The American Society of Gene & Cell Therapy Molecular Therapy 1
 

Summary:  the transduction efficiency of different adeno-associated virus (AAV) capsid serotypes encod- ing for green... revealed excellent transduction rates for each AAV pseudotype. Stereological estimates of GFP+ cells within... estimates revealed that AAV2/5-GFP resulted in a significantly ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
23 Intracellular trafficking of adeno-associated viral and JF Engelhardt1,2,3
 

Summary:  of recombinant AAV (rAAV) transduction has demonstrated considerable diversity in different cell types and target... tissues. This review will summarize the current understand- ing of events that control rAAV transduction... as intracellular trafficking and have been found to be a major ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
24 Recombinant Adeno-associated Viral Vectors as Therapeutic Agents to Treat Neurological Disorders
 

Summary:  inherent safety profile when used in the nervous system. The features of rAAV transduction proper- ties... report of successful rAAV- TPP1 transduction in normal mouse brain [129]. A clinical trial using rAAV2... but this level of brain transduction is not currently ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
25 Characterization of the Relationship of AAV Capsid Domain Swapping to Liver
 

Summary:  Characterization of the Relationship of AAV Capsid Domain Swapping to Liver Transduction Efficiency... cassette. By comparing the transduction efficiencies between vectors pseudotyped with chimeric, AAV2... and AAV8 capsids, we found that the more efficient liver ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
26 JOURNAL OF VIROLOGY, Mar. 2002, p. 20432053 Vol. 76, No. 5 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.5.20432053.2002
 

Summary:  and AAV-5 capsid particles, and transduction efficiencies in a number of cell lines were compared. Using... inhibitors not only increased the transduction efficiency of rAAV-2, as previously reported, but also... of the ubiquitin-proteasome system on rAAV-2 ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
27 HUMAN GENE THERAPY 18:871880 (October 2007) Mary Ann Liebert, Inc.
 

Summary:  ), to deliver shRNAs and silence bFGF in retinal pigment epithelial cells in vivo. The AAV experiments made use... (AAV) vectors can be used to deliver shRNAs to the rat retinal pigment epithelium (RPE) in vivo... .065 Rapid and Stable Knockdown of an Endogenous Gene in Retinal Pigment ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
28 Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer Superior
 

Summary:  Robust Systemic Transduction with AAV9 Vectors in Mice: Efficient Global Cardiac Gene Transfer... doses in mice that rAAV9 vectors share the robustness of rAAV8, i.e., (1) very high liver transduction... transduction following tail vein injection of as low as 1.0 Â ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
29 JOURNAL OF VIROLOGY, Mar. 2004, p. 31103122 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.31103122.2004
 

Summary:  (AAV2) vectors is ineffi- cient; less than 10% of hepatocytes are permissive for stable transduction... novo synthesis of the second strand (22). This might be a general property of AAV vector transduction... was not required for AAV transduction of polarized ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
30 HUMAN GENE THERAPY 15:405413 (April 2004) Mary Ann Liebert, Inc.
 

Summary:  -associated virus serotype 5 and 8 (AAV5LacZ, AAV8LacZ) carrying the LacZ reporter, and compared the transduction... transduction of the pancreas by AAV has not been demonstrated in vivo. It has been demonstrated that ex vivo... wanted to determine if different serotypes of ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
31 JOURNAL OF VIROLOGY, July 2003, p. 73617366 Vol. 77, No. 13 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.13.73617366.2003
 

Summary:  enhance rAAV-2 transduction from the apical surface of human polarized airway epithelia by modulating... to compare the extent to which LLnL alters transduction efficiencies with both rAAV-2 and rAAV-2/5 by using... that the coadministration of LLnL at the time of viral infection ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
32 Helper Virus-Free, Optically Controllable, and Two-Plasmid-Based Production of Adeno-associated
 

Summary:  of the AAV family, AAV-7 and -8, with the latter holding particular promise for liver transduction [15... serotype vector particles, is shown in Fig. 5. AAV Serotype Vector Particle-Mediated Transduction... ;knowledge of the transduction properties of ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
33 Current Gene Therapy, 2001, 1, 137-147 137 1566-5232/00 $20.00+.00 2001 Bentham Science Publishers Ltd.
 

Summary:  Publishers Ltd. Rate Limiting Steps of AAV Transduction and Implications for Human Gene Therapy S. Sanlioglu1... strategies capable of overcoming intracellular barriers to AAV2 transduction. The basis of these technologic... important for recombinant AAV (rAAV) ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
34 original article The American Society of Gene Therapy Molecular Therapy vol. 17 no. 2, 285293 feb. 2009 285
 

Summary:  AAV Transduction of Epithelial Progenitor Cells in Lung in vitro. These findings suggest that rAAV... diseases such as cystic fibrosis. results low-level cre expression following rAAV transduction... top panel), consistent with previous findings of inefficient rAAV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
35 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.16.76627671.2001
 

Summary:  -2cap5 (AAV-2 genomes pseudo-packaged into AAV-5 capsids). Despite similar levels of transduction... ) compared to rAAV-2. Serotype-specific differences in transduction efficiency did not directly correlate... with the activation of rAAV-2 ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
36 JOURNAL OF VIROLOGY, Mar. 2004, p. 28632874 Vol. 78, No. 6 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.6.28632874.2004
 

Summary:  - tion and transduction of recombinant adeno-associated virus type 2 (rAAV-2) and rAAV-5 serotypes... - tives) for their ability to induce rAAV transduction. The anthracycline derivatives doxorubicin... and aclarubicin also significantly augmented rAAV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
37 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  ) is the rate-limiting step for AAV vector transduction in vitro and in vivo (10, 11). Because integrated... OF STABLE IN VIVO LIVER TRANSDUCTION BY rAAV 9453 #12;FIG. 2. Southern blot analysis of the AAV.PMT vectors... OF STABLE IN VIVO LIVER TRANSDUCTION BY ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
38 original article The American Society of Gene Therapy Molecular Therapy vol. 16 no. 10, 17031709 oct. 2008 1703
 

Summary:  at titers similar to the parental viruses (AAV1, 2, 6, 8, and 9) (Supplementary Table S2). Transduction... revealed highly efficient liver and heart transduction by cA2 compared to AAV2, as well as enhanced... receptor or oth- erwise modulate the viral transduction. Furthermore, swapping ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
39 JOURNAL OF VIROLOGY, Jan. 2005, p. 214224 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.214224.2005
 

Summary:  adeno-associated virus (rAAV) vectors can mediate long-term stable transduction in various target... tissues. However, with rAAV serotype 2 (rAAV2) vectors, liver transduction is confined to only a small... whether rAAV vectors of other serotypes exhibit similar ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
40 JOURNAL OF VIROLOGY, Apr. 2005, p. 50475058 Vol. 79, No. 8 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.8.50475058.2005
 

Summary:  experiments with AAV5 have demonstrated improved binding and transduction * Corresponding author. Mailing... ]), does not appear to bind heparin. The carbohydrate moiety recognized by AAV1 for transduction has yet... affinity is weaker (49). However, AAV3 also lacks R585 and R588. ...

  

Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
41 ADVANCES IN VIRUS RESEARCH, VOL. 55 ADENO-ASSOCIATED VIRUS VECTOR-MEDIATED
 

Summary:  is essentially the entire life of the animal (28-30). Efficient transduction has been demonstrated in retinal (28... transduction efficiencies and the long persistence of transgene expression, rAAV has become a leading candidate... ) neuronal phe- notypes. Although AAV particle tropism ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
42 JOURNAL OF VIROLOGY, Apr. 2004, p. 33613371 Vol. 78, No. 7 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.7.33613371.2004
 

Summary:  not been identified. Hence, while transduction studies indicated that AAV5 can expand the utility of AAV... serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction... serotype 5 (AAV5) requires ...

  

Source: Baker, Timothy S. - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine

 
43 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  . To determine if the progression through the cell cycle was important for rAAV transduction, animals were... that there was no preference for transduction of cycling cells. This was further confirmed by demonstrating no increase in rAAV... -Gal, demonstrating that the majority of hepa- tocytes have ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
44 Loss of ATM Function Enhances Recombinant Adeno-Associated Virus Transduction and Integration through Pathways Similar to UV Irradiation
 

Summary:  . This enhancement of rAAV transduction in AT cells is correlated with an increased abundance of circular form rAAV... for increased rAAV transduction in AT cells, because binding, endocytosis, and nuclear trafficking of virus... are unaffected by the AT phenotype. Additionally, the ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
45 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  to increase transduction rates. Southern analysis and pulsed-field gel electrophoresis suggested that Ad.AAV... the expression cas- sette. Transduction studies with deleted Ad.AAV hybrid vectors in SKHEp-1 cells. To evaluate... the in vitro transduction effi- ciency of ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
46 Molecular Vision 2005; 11:1236-45 <http://www.molvis.org/molvis/v11/a141/> Received 5 July 2005 | Accepted 7 December 2005 | Published 30 December 2005
 

Summary:  in the retinal pigment epithelium (RPE) cells of the AAV-transduced eyes. Living photoreceptors of pAct.EGFP mice... - proximately 2 fold less than AAV2/5. High levels of EGFP do not interfere with retinal func- tion... .EGFP. Previous studies pro- vided qualitative data describing more efficient ...

  

Source: Sandini, Giulio - Dipartimento di Informatica Sistemistica e Telematica, Università degli Studi di Genova

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
47 ID weekly highlights Copyright Current Drugs Ltd, June 2002. ISSN 1365-5884 Middlesex House, 34-42 Cleveland Street, London W1T 4LB, UK http://www.current-drugs.com
 

Summary:  and transduction efficiencies emerge based on capsid serotype (eg, AAV2 and AAV2/5 for RPE), but much room remains... for improvement. SRS delivery predominates among successful examples of AAV gene transduction in photoreceptors... AAV-CBA-BIRC4. Levobetaxolol A ...

  

Source: Marc, Robert E. - Moran Eye Center, University of Utah

 

Collection: Biology and Medicine

 
48 HUMAN GENE THERAPY 10:591 602 (March 1, 1999) Mary Ann Liebert, Inc.
 

Summary:  have been demonstrated to enhance recombinant adeno-associated virus (rAAV) transduction. Such findings... stimuli increase rAAV transduction are only partially understood but have been suggested to involve both... that augmentation of rAAV transduction by UV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
49 Capsid modifications overcome low heterogeneous expression of heparan sulfate proteoglycan that limits AAV2-mediated gene transfer and therapeutic
 

Summary:  transduction and for sensitivity to ganciclovir (GCV) following AAVHSVtk administration. Levels of AAV... to wild-type AAV2 gene transfer, while providing a mechanism for transduction of target cells mediated... that are poorly transduced by AAV2, including some tumor cells. In these ...

  

Source: Hemminki, Akseli - Department of Biosciences, University of Helsinki

 

Collection: Biology and Medicine

 
50 GENE THERAPY Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors
 

Summary:  development of this system: first, the efficiency of in vivo liver transduction with AAV-2 is low because... in a variety of tissues (for a review, see Grimm18), but reports of AAV serotype transduction of the liver have... transduction of Huh-7 cells by the hFIX-expressing ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
51 JOURNAL OF VIROLOGY, June 2008, p. 58875911 Vol. 82, No. 12 0022-538X/08/$08.00 0 doi:10.1128/JVI.00254-08
 

Summary:  February 2008/Accepted 2 April 2008 Adeno-associated virus (AAV) serotypes differ broadly in transduction... for the complete transduction of liver tissue and perhaps other tissues makes these two non-AAV-2 serotypes also... " AAVs tailored for the therapeutic ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
52 original article 594 www.moleculartherapy.org vol. 18 no. 3, 594600 mar. 2010
 

Summary:  and rAAV5 transduction in four adult chimpanzees using the dual reporter system. A single mixture... , an ~20-fold greater level of rAAV1 transduction over rAAV5 was observed and this difference in luciferase... a ~20-fold higher level of rAAV1 ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
53 Investor and Media Contact: Stacie D. Byars
 

Summary:  efficiency that we can achieve with AAV vectors. In turn, increased transduction efficiency may help... that a number of small molecules have the ability to increase the efficiency of AAV transduction in cell culture... for use in other indications, may add to the efficiency of the AAV ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
54 Principal Investigator/Program Director (Last, first, middle): Samulski, Richard Jude BIOGRAPHICAL SKETCH
 

Summary:  Unique and Exclusive Long-term Transduction of Retinal Pigmented Epithelium in Rat, Dog and Non... transduction and persistence in airway cells using highly defined rAAV preps, a unique in vitro airway model... . Cross-packaging of a Single Adeno-associated Virus (AAV) Type 2 Vector ...

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
55 COLE DOCTORALE : DES GNOMES AUX ORGANISMES UNIVERSIT D'VRY VAL D'ESSONNE
 

Summary:  .................................................................................................................... 8 2.5. Mécanismes de transduction du vecteur AAV... ............................................................. 18 4. Stratégies d'amélioration de la transduction du vecteur AAV... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
56 JOURNAL OF VIROLOGY, Oct. 2007, p. 1130411321 Vol. 81, No. 20 0022-538X/07/$08.00 0 doi:10.1128/JVI.01225-07
 

Summary:  demonstrated that systemic administration of rAAV8 at 7.2 1012 vg/mouse results in substantial transduction... of adeno-associ- ated virus (AAV) are processed by DNA repair machinery; however, how and what cellular... factors are involved in the process remain elusive. Here, we show that DNA-PKcs and Artemis open ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
57 NATURE BIOTECHNOLOGY VOL 18 MAY 2000 http://biotech.nature.com 527 Recombinant adeno-associated virus (rAAV) vectors based on AAV
 

Summary:  2 and 3). Mice injected with AAV-Pless-nlsLacZ showed a low frequency of transduction at 0.5 ± 0... . Further studies into the mechanism of rAAV transduction are required to fully sort out these differences... following rAAV administrationa Transduction efficiencyb ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
58 Sustained Striatal Ciliary Neurotrophic Factor Expression Negatively Affects
 

Summary:  in the injected striatum of each mouse following transduction by rAAV2-CNTF. Tissue from 10 sections... sections on each slide are separated by 350 lm. Transduction of striatal neu- rons by rAAV2-CNTF increased... to determine the relative dis- tribution of neurons and NIIs following ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
59 Targeted Transgene Expression in Muller Glia of Normal and Diseased Retinas Using Lentiviral Vectors
 

Summary:  of immunosuppression.51,52 Unlike LV and Ad vectors, AAV vectors transduce retinal neurons with high efficiency,17... ,20 though their Mu¨ller cell transduction effi- ciency is extremely low.53 In addition, AAV transgene... retinal transduction at the vitreal surface ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
60 Directed evolution of adeno-associated virus to an infectious respiratory virus
 

Summary:  promoter and does not affect other transduction steps. Strikingly, 21 days posttransduc- tion, AAV2.5T... genome loss. No significant difference in basolateral transduction be- tween AAV2.5T and other wild... of improved transduction, apical binding was analyzed. Recombinant ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
61 Species-Specific Differences in Mouse and Human Airway Epithelial Biology of Recombinant
 

Summary:  biology. To this end, we compared rAAV2 and rAAV5 transduction biology in mouse and human ALI cultures... preferences for rAAV serotype transduction from the apical membrane (rAAV5 rAAV2) not seen in human epithelia... was not significantly ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
62 JOURNAL OF VIROLOGY, June 2004, p. 63446359 Vol. 78, No. 12 0022-538X/04/$08.00 0 DOI: 10.1128/JVI.78.12.63446359.2004
 

Summary:  . Preimmunization resulted in high levels of circulating NAb and prevented transduction by rAAV2 as assessed... by striatal GDNF levels. rAAV2-GFP striatal transduction was also prevented by immunization, while rAAV5-GFP... (14, 34). These studies used rAAV, not wt ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
63 Enhanced Preparation of Adeno-Associated Viral Vectors by Using High Hydrostatic Pressure to
 

Summary:  transduction chamber of the hyperbaric device. AAV DNAse I Digestion and Quantitative Real-Time PCR (QPCR) Five... is that adenovirus co-infection has been shown to increase AAV transduction efficiency by enhancing AAV second strand... ratios and assayed for Luc expression. ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
64 JOURNAL OF VIROLOGY, Jan. 2006, p. 426439 Vol. 80, No. 1 0022-538X/06/$08.00 0 doi:10.1128/JVI.80.1.426439.2006
 

Summary:  conclude that, unlike serotypes, AAV genotypes are not critical for efficient hepatocyte transduction... TRANSDUCTION 427 #12;(25). A drawback of this uniqueness is that the AAV-5 geno- type is hard to pseudotype... . Interestingly, Hal- bert et al. found that vectors with AAV-2, -3, or ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
65 The idea of gene-based therapeutics has been around for some time, but it only received serious attention
 

Summary:  are episo- mal. Thus, <1% of AAV proviral transduction can be attributed to integration54,55 . Integration... trials. One of the most notable trials includes retinal infusion of an AAV2 vector containing the RPE65... -associated viruses (AAVs) with different ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
66 Light-Driven Cone Arrestin Translocation in Cones of Postnatal Guanylate Cyclase-1 Knockout Mouse Retina
 

Summary:  ) vectors that exhibit a higher transduction efficiency and a faster onset of expression than other AAV... Retina Treated with AAV-GC1 Shannon E. Haire,1 Jijing Pang,2 Sanford L. Boye,2 Izabel Sokal,3 Cheryl M... . Subretinal injections of AAV-GC1 were performed on 3-week-old GC1 KO mice. Electroretinographic ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
67 [23] Adeno-Associated Virus Vectors for Short Hairpin RNA Expression
 

Summary:  this tissue, whereas AAV-8 appears superior among all serotypes for liver transduction (Gao et al., 2002... of the natural AAV-2 tropism while allowing the transduction of cell types that had previously been refractory... demonstrated that transduction with AAV ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
68 Ribozyme rescue of photoreceptor cells in P23H transgenic rats: Long-term survival and
 

Summary:  significant photoreceptor cell loss. Recom- binant adeno-associated virus (rAAV) vectors incorporating a prox... to photoreceptors. For the study of long-term survival, rAAV was administered by subretinal injection at P15... , and the rats were allowed to live up to 8 months of age. For the study of late-stage gene transfer, rAAV

  

Source: Príncipe, José Carlos - Computational NeuroEngineering Laboratory, University of Florida

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
69 ELSEVIER Virus Research 48 (1997) 41-56 Structural and functional heterogeneity of integrated
 

Summary:  that the transduction and integra- tion biology of rep minus recombinant AAV may differ greatly from rep inclusive wild... and efficiency of transduction. For ex- ample, studies in rabbits demonstrate that re- combinant AAV is capable... demon- strate only low levels of transduction with ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
70 JOURNAL OF VIROLOGY, Oct. 2007, p. 1129011303 Vol. 81, No. 20 0022-538X/07/$08.00 0 doi:10.1128/JVI.00963-07
 

Summary:  shown that recombinant adeno-associated virus (rAAV) vector integrates preferen- tially in genes, near... method relied on in vivo selection of rAAV integrants and could be employed for the liver... but not for other tissues. Here, we describe a novel method for high-throughput rAAV integration site analysis

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
71 ORIGINAL ARTICLE Surface immobilization of hexa-histidine-tagged
 

Summary:  , a human melanoma cell line reported to be nonpermissive to AAV transduction,21 was equivalent or slightly... quantitative PCR to estimate the amount of cell-internalized AAV vectors. Transduction assay At several time... , Berkeley, CA, USA Adeno-associated viral (AAV) vectors, which are ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
72 JOURNAL OF VIROLOGY, 0022-538X/00/$04.00 0
 

Summary:  1999 Adeno-associated virus (AAV) is inefficient at infecting differentiated airway epithelia because... of a lack of receptors at the apical surface. We hypothesized that incorporation of AAV in a calcium... phosphate coprecipi- tate would circumvent this barrier. Interestingly, coprecipitation of AAV type 2

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
73 JOURNAL OF VIROLOGY, Nov. 2002, p. 1134311349 Vol. 76, No. 22 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.22.1134311349.2002
 

Summary:  of liver transduction are not fully understood, and furthermore, the relationships between rAAV dose... and provides further insights into the mechanisms of rAAV transduction in the liver. Adeno-associated virus... stable hepatocyte transduction with rAAV have been ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
74 original article 524 www.moleculartherapy.org vol. 17 no. 3, 524537 mar. 2009
 

Summary:  transduction. In addition, because the brain is relatively immunoprivileged, intracranial rAAV transduction may... antibodies (nAbs) to block brain transduction and rAAV readministration in the brain leads to an inflammatory... real-time PCR. We conclude that intracel- lular processing ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
75 MOLECULAR AND CELLULAR BIOLOGY, May 2003, p. 35583565 Vol. 23, No. 10 0270-7306/03/$08.00 0 DOI: 10.1128/MCB.23.10.35583565.2003
 

Summary:  promoter. We used rAAV-GFP to measure the frequencies of transduction and random integration. rAAV.LacZ has... . Random integration with rAAV. (A) The time course of rAAV transduction is illustrated. This graph shows... representative examples of the time course of ...

  

Source: Baltimore, David - Division of Biology, California Institute of Technology

 

Collection: Biotechnology ; Biology and Medicine

 
76 Sites in the AAV5 capsid tolerant to deletions and tandem duplications Kaoru Hida a
 

Summary:  and transduction efficiencies of recombinant AAV-GFP-actin. Mutationa Occurencesb rAAV-GFP titerc Transduction... Sites in the AAV5 capsid tolerant to deletions and tandem duplications Kaoru Hida a , Sang Y. Won b... January 2010 Available online 25 January 2010 Keywords: Directed ...

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
77 HUMAN GENE THERAPY 18:8187 (January 2007) Mary Ann Liebert, Inc.
 

Summary:  -ITR vectors (AV5:2LacZ- YAN ET AL.82 FIG. 1. Efficiency of rAAV transduction in mouse muscle is not affected... demonstrate that AAV2 and AAV5 ITRs facilitate similar levels of rAAV transduction and genome conversion... (Yan et al., 2006) and Doxil also enhances ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
78 HUMAN GENE THERAPY 16:299306 (March 2005) Mary Ann Liebert, Inc.
 

Summary:  the relative level of transduction. First, we delivered an AAV vector expressing the human factor IX gene from... dwell time affected AAV transduction in vivo. To do this, we infused an AAV vector lacking a functional... that arose in previous experiments is that even at higher ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
79 JOURNAL OF VIROLOGY, Jan. 2005, p. 364379 Vol. 79, No. 1 0022-538X/05/$08.00 0 doi:10.1128/JVI.79.1.364379.2005
 

Summary:  of the molecular virol- ogy of rAAV transduction has improved significantly. We now have a better understanding... and the involve- ment of the ubiquitin/proteasome system has led to methods to improve rAAV transduction... elucidating the transduction biology of ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
80 Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work.
 

Summary:  as an intravitreally injected control. {Intravitreal injection of AAV2 does not result in transduction of retinal... of RPE65 in retinal pigment epithelium cells transduced by AAV2.hRPE65v2.4 Surgical trauma alone... VR, et al. Successful transduction of liver in ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
81 HUMAN GENE THERAPY 18:367378 (April 2007) Mary Ann Liebert, Inc.
 

Summary:  ) Representative transduction titers of recombinant GFP vector packaged with wild-type AAV2 capsid, His6 AAV2... transduction titers of recombinant GFP vector packaged by wild-type AAV2 and His6 AAV2 on several cell lines... expressing various levels of HSPG, and ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
82 MOLECULAR THERAPY Vol. 6, No. 3, September 2002 Copyright The American Society of Gene Therapy
 

Summary:  . We now report that transduction with AAV particles carrying the wild-type PDH E1 cDNA can par- tially... low levels of PDH activity. Transduction with the rAAV-PDH vector was performed in parallel with an rAAV... after animal necropsy. Stereotaxic injection of ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
83 Copyright Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited. Gene therapy for hemophilia
 

Summary:  Manno CS, Arruda VR, Pierce GF, et al. Successful transduction of liver in hemophilia by AAV-Factor IX... -associated virus vector (AAV vector), adenoviral vector, gene therapy, hemophilia, retroviral vector Curr Opin... -mail: kponder@im.wustl.edu Current Opinion in Hematology 2006, 13:301­307 Abbreviations ...

  

Source: Ponder, Katherine P. - Departments of Medicine & Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
84 JOURNAL OF VIROLOGY, Apr. 2003, p. 47514759 Vol. 77, No. 8 0022-538X/03/$08.00 0 DOI: 10.1128/JVI.77.8.47514759.2003
 

Summary:  process facilitating long-term rAAV transduction in muscle. A recent study (S. Song, P. J. Laipis, K. I... in the abundance of rescued circular genomes, despite equivalent levels of single rAAV transduction seen in wild... AAV episomes are responsible for long- term ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
85 HUMAN GENE THERAPY 18:344354 (April 2007) Mary Ann Liebert, Inc.
 

Summary:  SUMMARY We have previously shown that AAV6 vectors promote rel- atively high rates of transduction... in the airway epithelium of animals. Here we have examined transduction by AAV6 vectors containing various... to heparin and AAV1 does not (Halbert et al., 2001), and ...

  

Source: Miller, Dusty - Division of Human Biology, Fred Hutchinson Cancer Research Center

 

Collection: Biology and Medicine

 
86 Directed evolution of adeno-associated virus yields enhanced gene delivery vectors
 

Summary:  DNA Sequencing Facility. In vitro transduction assays. Either wild-type or mutant rAAV-GFP particles... Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity. J. Virol. 76, 791... (AAV) 2 variants with enhanced properties. High-throughput selection processes were ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry

 
87 JOURNAL OF VIROLOGY, 0022-538X/01/$04.00 0 DOI: 10.1128/JVI.75.15.69696976.2001
 

Summary:  , 2001 EPISOMAL AAV GENOMES FOR PERSISTENT LIVER TRANSDUCTION 6971 #12;hF.IX expression observed after 3... EPISOMAL AAV GENOMES FOR PERSISTENT LIVER TRANSDUCTION 6973 #12;suggests that the relative number... , 2001 EPISOMAL AAV GENOMES FOR PERSISTENT LIVER ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
88 Systemic Mannitol-Induced Hyperosmolality Amplifies rAAV2-Mediated Striatal Transduction to a
 

Summary:  Systemic Mannitol-Induced Hyperosmolality Amplifies rAAV2-Mediated Striatal Transduction... system (CNS). Transduction with rAAV2 vectors results in long-term transgene expression in CNS neurons... , and transduction of quiescent cells [1]. rAAV2 has been used ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
89 NATURE BIOTECHNOLOGY VOLUME 25 NUMBER 10 OCTOBER 2007 1111 and drugs that act directly on disease genes.
 

Summary:  -broken portions of the chromo- some8,9. Moreover, even if a small percent- age of the rAAV proviral transduction... Figure 1 Model of AAV-mediated oncogenesis. AVV vector transduction normally results in maintenance... and hubs. AAV vectors and tumorigenicity Mark A Kay Chromosomal ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
90 RAPID COMMUNICATION Structural Analysis of Adeno-Associated Virus Transduction Circular Intermediates
 

Summary:  for the existence of circular AAV genomes in latent phase transduction. Similar to previous reports (6), the monomer... COMMUNICATION #12;represents a new and potentially important aspect of the rAAV viral transduction process... in the formation of AAV transduction ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
91 original article 1212 www.moleculartherapy.org vol. 19 no. 7, 12121219 july 2011
 

Summary:  -stage retinal degeneration, AAV gene therapy could be used to transfer exogenous light sensors to surviving... retinal neurons. AAV vectors of defined serotypes carrying cell-specific pro- moters can target expression... , AM, Berns, KI, Flannery, JG et al. (2004). Range of retinal ...

  

Source: Trauner, Dirk - Department Chemie, Ludwig Maximilians Universität München

 

Collection: Chemistry

 
92 RNAi based gene therapy for Spinocerebellar ataxia-7 HHMI Med-Into-Grad Proposal
 

Summary:  in retinal pathology and function AAV vectors expressing the SCA7 mutant allele specific shRNA and an hr... , Chiorini, JA and Davidson, BL. Transduction of murine cerebellar neurons with recombinant FIV and AAV5... by an expanded CAG repeat mutation in the ataxin-7 gene, is unique amongst the SCAs in that it ...

  

Source: Gleeson, Joseph G. - Department of Neurosciences, University of California at San Diego

 

Collection: Biology and Medicine

 
93 Gene Transfer Mediated by Recombinant Baculovirus into Mouse Eye
 

Summary:  in anterograde fashion after subretinal injec- tion.37 rAAV is able to transduce the widest range of retinal cell... expression obtained after transduction by rAAV, AV, and len- tivirus, is more efficient in photoreceptor... - sion in vivo was observed exclusively in retinal pigment epi- ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
94 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1408314088, December 1997
 

Summary:  in the present study (1,235 pg and 747 pg, respectively; see Table 1) as a result of AAV transduction... (17, 18) or rAAV transduction (see Results) further suggests that there is a wide therapeutic window... A recombinant adeno-associated virus (rAAV) vector capable of infecting cells ...

  

Source: Mandel, Ronald J. - Department of Neuroscience, University of Florida

 

Collection: Biology and Medicine

 
95 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  , and the mechanisms underlying transgene persistence in the liver after rAAV vector transduction have not been... January 1999/Accepted 30 March 1999 Recombinant adeno-associated virus (rAAV) vectors allow for sustained... expression of transgene products from mouse liver following a single portal vein administration. Here a ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
96 original article The American Society of Gene & Cell Therapy Molecular Therapy vol. 18 no. 5, 873880 may 2010 873
 

Summary:  model of MPS IIIB, neo- natal mice were treated with intracranial AAV2/5-NAGLU (AAV), syngeneic bone... marrow transplant (BMT), or both (AAV/BMT). All treatments resulted in some improve- ment in clinical... phenotype. Adeno-associated viral (AAV) treatment resulted in improvements in lifespan, motor ...

  

Source: Orrock, John - Department of Zoology, University of Wisconsin at Madison

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
97 MOLECULAR THERAPY Vol. 4, No. 6, December 2001 Copyright The American Society of Gene Therapy
 

Summary:  . Louis, MO). Transduction of murine spermatogonia and Sertoli cells by AAV vector encoding Lac... ) were similarly transduced with AAV- CMV-LacZ as controls for the transduction experiments... of Germline Transmission of Vector Sequences Following Systemic Administration of Recombinant ...

  

Source: Kay, Mark A. - Department of Genetics, Stanford University

 

Collection: Biology and Medicine

 
98 JOURNAL OF VIROLOGY, 0022-538X/99/$04.00 0
 

Summary:  the transduction efficiency of rAAV is markedly variable in different cell types. For ex- ample, rAAV has been... . In summary, these studies have increased our understanding of mechanisms involved in rAAV transduction... , Iowa Received 15 April 1999/Accepted 26 July 1999 Long-term ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
99 Palmitoylation stabilizes unliganded rod opsin Akiko Maedaa,b,1
 

Summary:  rather than aberrant signal transduction resulted in retinal pathology. Together, these observations pro... light-induced retinal degen- eration that first involved rod and then cone cells. After brief bright... retinal degeneration occurred even in 3- to 4-week-old animals. This rapid degeneration suggests

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
100 Construction of diverse adeno-associated viral libraries for directed evolution of enhanced gene
 

Summary:  , random adeno-associated viral (AAV) libraries that can be selected for a desired function. First, the AAV... extension process. The resulting PCR product is then cloned into pSub2 to generate a diverse (>106) AAV2... plasmid library. Finally, the AAV2 plasmid library is used to package a diverse pool of ...

  

Source: Long, Jeffrey R.- Department of Chemistry, University of California at Berkeley

 

Collection: Materials Science ; Chemistry


Page:   1  2  3  4  5