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Sample search results for: a-kinase anchoring proteins

Page:   2  3  4  5 
 
1 List of publications List of publications
 

Summary:  , Van der Zee EA, Eisel UL. Inhibition of PKA anchoring to A-kinase anchoring proteins impairs... : Ostroveanu A, Van der Zee EA, Luiten PG, Eisel UL, Nijholt IM. 2008. Role of A-kinase anchoring proteins... A, Van der Zee EA, Luiten PG, Eisel UL, ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
2 Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated
 

Summary:  ) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past... Science Ltd. All rights reserved. Abbreviations AKAP A-kinase anchoring protein PKA protein kinase A PKC... holoenzyme forms may be ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
3 -Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The
 

Summary:  to subcellular organelles and membranes. In particular, we highlight the A-kinase anchoring proteins (AKAPs... Densities by A-Kinase Anchoring Proteins. Characterization of AKAP 79. J Biol Chem 67:16816­16823. 16... Regulatory Subunit (RII) of the cAMP-Dependent ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
4 Novel cyclic AMP signalling avenues in learning and memory
 

Summary:  ;#12;Contents Chapter 1 Introduction and aim of the thesis 9 Chapter 2 A-kinase anchoring protein 150... Chapter 4 Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and facilitates... to a novel context and ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
5 Signalling the Future 87 A-kinase-anchoring proteins and cytoskeletal
 

Summary:  Signalling the Future 87 A-kinase-anchoring proteins and cytoskeletal signalling events J.D. Scott1... through interaction with A-kinase-anchoring proteins (AKAPs). The present paper discusses recent progress... orientation of PKA is controlled through as- sociation with ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
6 Regulation of ion channels by CAMP-dependent protein kinase and A-kinase anchoring proteins
 

Summary:  330 Regulation of ion channels by CAMP-dependent protein kinase and A-kinase anchoring proteins... -dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent... . At the ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
7 Brief Communication 417 Pericentrin anchors protein kinase A at the centrosome through
 

Summary:  compartmentalization of PKA is achieved through the association of the PKA holoenzyme with A-kinase anchoring proteins... Pericentrin is an A-kinase anchoring protein. (a) HEK-293 cells grown in 100 mm dishes were transfected with 5... , Jennings PA: The ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
8 INTRODUCTION Extracellular signals, such as hormones, neu-
 

Summary:  A (PKA) mediated by A-kinase anchoring proteins (AKAPs). The Role of A-Kinase Anchoring Proteins in c... with A-kinase anchoring proteins (AKAPs). AKAPs mediate a high-affinity interaction with the type ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
9 A-kinase anchoring proteins and neuronal signaling mechanisms
 

Summary:  REVIEW A-kinase anchoring proteins and neuronal signaling mechanisms Graeme K. Carnegie and John D... ) through its associa- tion with A-kinase anchoring proteins (AKAPs). cAMP-dependent signaling mechanisms... is an A- kinase ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
10 Organizing signal transduction through A-kinase anchoring proteins (AKAPs)
 

Summary:  MINIREVIEW Organizing signal transduction through A-kinase anchoring proteins (AKAPs) Jeremy S... by A-kinase anchoring proteins. This family of proteins assembles enzyme complexes containing the c... to optimize cellular responses to cAMP and ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
11 This Review is part of a thematic series on Microdomains in Cardiovascular Signaling, which includes the following articles
 

Summary:  : The Role of A-Kinase Anchoring Proteins Targeting Cyclic Nucleotide Signaling G Protein­Coupled Receptor... in the Heart The Role of A-Kinase Anchoring Proteins Kimberly L. Dodge-Kafka, Lorene Langeberg, John D. Scott... the association with ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
12 An entirely specific type I A-kinase anchoring protein that can sequester two molecules
 

Summary:  An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein... of nonca- talytic modulator proteins called A-kinase anchoring proteins (AKAPs) (21). To date 47 human AKAP... A signal- ing ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
13 Introduction Protein phosphorylation is a tightly regulated process that is
 

Summary:  . The intracellular organization of PKA is controlled through association with A-kinase-anchoring proteins (AKAPs... with A-kinase anchoring proteins (AKAPs). AKAPs maintain multivalent signaling complexes by binding... and functional similarities to the A- ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
14 NATURE CELL BIOLOGY VOL 4 AUGUST 2002 http://cellbio.nature.com E203 Kinase-and phosphatase-anchoring
 

Summary:  in response to developmental cues. A-kinase-anchoring proteins Most effects of the second messenger c... signals. a b c Figure 3 A-kinase-anchoring proteins. a, A schematic diagram of the CG-NAP/AKAP350... ­497 (2001). 41. Rubin, C. S. A-kinase anchor ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
15 Summary of the thesis Summary of the thesis
 

Summary:  of cAMP-dependent protein kinase (PKA) anchoring to A-kinase anchoring proteins (AKAPs) and the newly... of scaffolding proteins called A-kinase anchoring proteins (AKAPs). We discuss how several AKAPs and ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
16 Critical Review A-kinase Anchoring Proteins: From Protein Complexes to Physiology
 

Summary:  Critical Review A-kinase Anchoring Proteins: From Protein Complexes to Physiology and Disease... functions. One family of diverse, well-studied scaffolding proteins are the A-kinase anchoring proteins... signaling complexes to ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
17 ISSN: 1524-4539 Copyright 2010 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online
 

Summary:  . Santana A-Kinase Anchoring Proteins: Getting to the Heart of the Matter http... .ahajournals.orgDownloaded from #12;Basic Concepts in Heart Failure A-Kinase Anchoring Proteins Getting to the Heart of the Matter... A-kinase ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
18 Section 4: -Cell Stimulus-Secretion Coupling: Metabolic Factors
 

Summary:  of compartmentalization of multivalent signaling complexes by A-kinase anchoring proteins (AKAPs) and the functional... (22,23). A-KINASE ANCHORING PROTEINS The first AKAPs were originally discovered as contami- nants... , Vossebein L, Tasken K: Analysis of ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
19 Biochem. J. (2006) 400, 493499 (Printed in Great Britain) doi:10.1042/BJ20060962 493 Characterization of A-kinase-anchoring disruptors using
 

Summary:  characterization of a variety of PKA­AKAP complexes. Key words: A-kinase-anchoring protein (AKAP), Amplified... through protein­protein interactions of the R subunit with AKAPs (A-kinase-anchoring proteins), a diverse... used: AKAP, A-kinase-anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
20 A-kinase-anchoring Lorene K. Langeberg and John
 

Summary:  A-kinase-anchoring proteins Lorene K. Langeberg and John D. Scott* Howard Hughes Medical Institute... of proteins known as A-kinase- anchoring proteins (AKAPs). AKAPs provide a framework for the coordination... /15 A-kinase-anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine


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21 The where's and when's of kinase F. Donelson Smith, Lorene K. Langeberg and John D. Scott
 

Summary:  to synchronize spatial and temporal aspects of cell signaling. A-kinase anchoring proteins (AKAPs) are a diverse... ) Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins... , 4072­4077 22 ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
22 FunctionalAnchoringof the cAMP-DependentProteinKinase
 

Summary:  : 1993. Follicle- stimulating hormone regulation of A- kinase anchoring proteins in granulosa cells... of mouse sperm: structuraland functional similari- ties to the A-kinase anchoring proteins. Dev Biol 165... with a common anchoringprotein. ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
23 Molecular Cell, Vol. 15, 889899, September 24, 2004, Copyright 2004 by Cell Press AKAP-Lbc Nucleates a Protein Kinase D
 

Summary:  (Carr et al., 1992). Recently, we and others have demonstratedstrate that the A-kinase anchoring protein... , 1997). AKAP-Lbc Binds to PKD A-Kinase Anchoring Proteins (AKAPs) are a family of AKAP-Lbc binds protein... ). mAKAP ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
24 Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and
 

Summary:  Chapter 4 Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation... signaling is mediated by A-kinase anchoring proteins (AKAPs). Here, we investigated the role of PKA... A-kinase ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
25 A-kinase anchoring proteins take shape Darren L Beene and John D Scott
 

Summary:  A-kinase anchoring proteins take shape Darren L Beene and John D Scott A-kinase anchoring proteins... many different functions. One family of scaffolding proteins are the A-kinase anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
26 Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract
 

Summary:  association with A-kinase anchoring proteins (AKAPs). Recent data suggest that some AKAPs also interact... could sample localised cAMP gradients [13­15]. The discovery of A-kinase anchoring proteins (AKAPs) has... and phosphatases utilise common mechanisms to ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
27 AKAP signaling complexes: getting to the heart of the matter
 

Summary:  compartmentalization of protein kinases and phosphatases through their interaction with A-kinase anchoring proteins... AMP signaling. A-kinase anchoring proteins: focal points in cAMP signaling Binding of extracellular messengers... monophosphate ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
28 2011LandesBioscience. Donotdistribute.
 

Summary:  by an interaction with the A-kinase anchoring protein AKAP220. Phosphorylation of IQGAP2 via AKAP220-anchored PKA... ," we identify a cortical actin cyto- skeletal signaling complex containing an A-Kinase Anchoring... LB, Coghlan VM, Nauert B, Scott JD. Cloning and ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
29 General Discussion 1. The role of A-kinase anchoring protein 150 in learning and memory
 

Summary:  Chapter 7 General Discussion #12;Chapter 7 Content 1. The role of A-kinase anchoring protein 150... . The role of A-kinase anchoring protein 150 (AKAP150) in learning and memory Recently, A-kinase anchoring... Kinase to the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
30 The Journal of Clinical Investigation | March 1999 | Volume 103 | Number 6 761 The issue of specificity in cellular signaling has attract-
 

Summary:  holoenzyme through association with A-kinase anchoring proteins (AKAPs) (7). The AKAPs are a functionally... . AKAPs, A- kinase anchoring proteins. #12;ponent that has been proposed to anchor PKA (18,19). Because... ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
31 2004 NaturePublishing Group Where and when enzymes become active have pro-
 

Summary:  examples of these signal-orga- nizing molecules are the A-kinase anchoring proteins (AKAPs), which... framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs... as exchange proteins activated by cAMP ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
32 Both exposure to a novel context and associative learning induce an upregulation of AKAP150
 

Summary:  3 Abstract A-kinase anchoring protein 150 (AKAP150) is a multi-enzyme signaling complex... ) is tightly controlled by a family of A-kinase anchoring proteins (AKAPs) (Rubin, 1994). AKAPs have been shown... by A-kinase ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
33 The EMBO Journal Vol.17 No.8 pp.22612272, 1998 A novel lipid-anchored A-kinase Anchoring Protein
 

Summary:  The EMBO Journal Vol.17 No.8 pp.2261­2272, 1998 A novel lipid-anchored A-kinase Anchoring Protein... have cloned a low-molecular weight A-kinase Anchoring Protein, called AKAP18, which targets the c... of the PKA holoenzyme with ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
34 Introduction and aim of this thesis 1. cAMP signaling in learning and memory
 

Summary:  of PKA signaling through AKAPs 5. A-kinase anchoring protein 150 6. Muscle AKAP 7. Role of AKAPs... discovered, cAMP signaling avenues, A-kinase anchoring proteins (AKAPs) and exchange protein activated by c... . In this thesis we focus on the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
35 Sleep deprivation induces hippocampal AMPA receptor dephosphorylation: a possible role of
 

Summary:  decreased protein levels of the A-kinase anchoring protein 150 (AKAP150). The reduc- tion in S845... to the scaffolding molecule A-kinase anchoring protein 150 (AKAP150) which targets both proteins to the postsynaptic... by ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
36 CompartmentalizationofCyclicAMPSignallingBiochemicalSocietyFocusedMeeting Compartmentalization of Cyclic AMP
 

Summary:  . Multifunctional binding proteins such as the AKAPs (A-kinase- anchoring proteins) oversee the dynamic organization... - fied to be sensitive to cAMP, or PKA subunits which have Key words: A-kinase-anchoring protein (AKAP... cyclase; AKAP, ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
37 BIOLOGY OF REPRODUCTION 58, 1496-1502 (1998) Regulation of Expression of A-Kinase Anchoring Proteins in Rat Granulosa Cells
 

Summary:  through the interaction of the regulatory sub- units with A-kinase anchoring proteins (AKAPs). We... that the anchoring of PKA through its interaction with other cellular proteins referred to as A-kinase anchoring... . Localiza- tion of the ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
38 Cell, Vol. 85, 912, April 5, 1996, Copyright 1996 by Cell Press Molecular Glue: Kinase Anchoring Minireview
 

Summary:  ) with A-Kinase Anchoring Proteins, called AKAPs. PKC is tethered to the cytoskel- eton or at submembrane... ) and anchoring proteins which are tethered to subcellular structures and localize their complement of enzymes... of scaffold and anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
39 Loss of AKAP150 perturbs distinct neuronal processes Brian J. Tunquist*
 

Summary:  of signal transduction pathways. A- Kinase Anchoring Proteins (AKAPs) target various protein kinases... to the postsynaptic densities by A-kinase anchoring proteins: Characterization of AKAP79. J Biol Chem 24... :261­275. 14. ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
40 INTRODUCTION The classical picture of extracellular signals leading to a
 

Summary:  Ther 1991; 50: 123­145. 4. Scott JD, McCartney S. Localization of A-kinase through anchoring proteins... with A-kinase anchor proteins requires isoleucines 3 and 5. J Biol Chem 1994; 269: 24245­24251. 8. Dell... , Nauert B, Scott JD. Cloning and characterization of ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine


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41 Neuron, Vol. 23, 423426, July, 1999, Copyright 1999 by Cell Press Modulation of Ion Channels: Minireview
 

Summary:  is mediated by PP-1. AMPA currents were tion with A-kinase anchoring proteins (AKAPs). AKAPs maintained... and Levitan, 1995; Yu et al., 1997). In the dress which anchoring protein performed this role atcase... and anchoring proteins. al. (1999) ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
42 216 0962-8924/99/$ see front matter 1999 Elsevier Science. All rights reserved. trends in CELL BIOLOGY (Vol. 9) June 1999 PII: S0962-8924(99)01558-5
 

Summary:  ) through the use of A-kinase anchoring proteins (AKAPs). cAMP signalling pathways and AKAPs One of the best... effectors and substrates. For example, `A-kinase anchoring proteins' (AKAPs) bind to the regulatory subunit... sub- unit activity from cell extracts by ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
43 2011LandesBioscience. Donotdistribute.
 

Summary:  -signal regulated kinase; MAPK, mitogen-activated protein kinase; AKAP, A-kinase anchoring protein; PKA, c... We recently discovered that KSR-1 and the A-Kinase Anchoring Protein (AKAP)- Lbc form the core... the establishment of larger multi- ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
44 Formation and Adaptation Neurobiological mechanisms underlying learning
 

Summary:  dephosphorylation: a possible role of A-kinase anchoring protein (AKAP)-150 Chapter 7: Sleep deprivation prevents... in the Y maze does not affect 93 striatal PKA and calcineurin protein levels or the phosphorylation state

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
45 Signaling Complexes : Junctions on the Intracellular Information Super
 

Summary:  Hyperosmotic stress response #12;Review R34 A-Kinase Anchoring Proteins A-kinase anchoring proteins (AKAPs... phosphatase PP1 with the A-kinase anchor- ing protein AKAP220. Curr. Biol. 9, 321­324. 42. ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
46 Biochem. J. (1999) 343, 443452 (Printed in Great Britain) 443 Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein
 

Summary:  regulate their location and activity [3,5]. For example, A-kinase- anchoring proteins (AKAPs) bind... scaffold co-ordinating the phos- Abbreviations used: AKAP, A-kinase-anchoring protein; PKC, protein kinase... Biochem. J. (1999) 343, 443­452 (Printed in Great ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
47 European Journal of Cell Biology 85 (2006) 585592 Anchored cAMP signaling: Onward and upward A short history of
 

Summary:  of different path- way components by A-kinase anchoring proteins (AKAPs). This review discusses the history... AMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase... anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
48 Protein Kinase A Anchoring* Mark L. Dell'Acqua and John D. Scott
 

Summary:  -binding proteins were renamed A-kinase anchoring proteins or AKAPs to account for their proposed PKA- targeting... , A-kinase- anchoring protein; MAP, microtubule-associated protein; AMPA, -amino-3- hydroxy-5-methyl-4... ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
49 Brief Communication 409 Assembly of an A kinase-anchoring protein2-adrenergic receptor
 

Summary:  for co-purifying A-kinase anchoring proteins (AKAPs) by an in vitro overlay procedure using radiolabeled... kinase to the postsynaptic densities by A-kinase anchoring proteins: characterization of AKAP79. J Biol... to the 2-AR at the plasma membrane have not been ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
50 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1494214947, December 1997
 

Summary:  with A-kinase-anchoring proteins (AKAPs) facilitates GLP-1- mediated insulin secretion. Disruption of PKA... of the regulatory subunit dimer (RII) with a family of A-kinase- anchoring proteins (AKAPs) (6, 7). Anchoring... AMP-dependent protein ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
51 Molecular Cell 23, 925931, September 15, 2006 2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.07.025 Short ArticleDynamic Regulation of cAMP
 

Summary:  of the enzyme near its substrates through association withA-kinase anchoring proteins (AKAPs). Here, we provide... .P., Vasta, V., Beavo, J.A., and Carr, D.W. (2004). A-kinase anchoring proteins interact... .Y. (2004). AKAPs (A-kinase ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
52 Cloning and Characterization of a Novel A-kinase Anchoring Protein
 

Summary:  Cloning and Characterization of a Novel A-kinase Anchoring Protein AKAP 220, ASSOCIATION... ) with A-kinase anchoring proteins (AKAPs). Using an interaction cloning strategy with RII as a probe, we... . This is achieved, in part, through the association of the kinase ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
53 The Rockefeller University Press, 0021-9525/99/12/1481/12 $5.00 The Journal of Cell Biology, Volume 147, Number 7, December 27, 1999 14811492
 

Summary:  the Subcellular Localization of A-kinase Anchoring Protein 18 Isoforms Kevin W. Trotter,* Iain D.C. Fraser... compartments by as- sociation with A-kinase anchoring proteins (AKAPs). AKAPs are a family of functionally... @med.unc.edu 1. Abbreviations used in this ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
54 Brief Communication 321 Association of the type 1 protein phosphatase PP1 with the
 

Summary:  subunits with A-kinase anchoring proteins (AKAPs), whereas a diverse family of phosphatase... , Scott JD: Cloning and characterization of a novel A-kinase anchoring protein, AKAP 220, association... Brief Communication 321 Association of the type 1 ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
55 SYNAPTIC AND SUBCELLULAR LOCALIZATION OF A-KINASE ANCHORING PROTEIN 150 IN RAT HIPPOCAMPAL CA1 PYRAMIDAL
 

Summary:  SYNAPTIC AND SUBCELLULAR LOCALIZATION OF A-KINASE ANCHORING PROTEIN 150 IN RAT HIPPOCAMPAL CA1... to specific subcellular locations by one of several anchoring proteins. One of these is the A-kinase anchoring... , receptor phosphorylation, receptor ...

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University; Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
56 A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved in learning
 

Summary:  Chapter 2 A-kinase anchoring protein 150 in the mouse brain is concentrated in areas involved... ;Chapter 2 Abstract A-kinase anchoring proteins (AKAPs) form large macromolecular signaling complexes... the association of the enzyme with so-called ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
57 Mapping the Protein Phosphatase-2B Anchoring Site on AKAP79 BINDING AND INHIBITION OF PHOSPHATASE ACTIVITY ARE MEDIATED BY RESIDUES 315360*
 

Summary:  to increase the effi- cacy of signal transduction events. The A-kinase anchor- ing protein, AKAP79... ­3). For example, A-kinase anchor- ing proteins (AKAPs)1 bind the regulatory (R) subunit of the c... The abbreviations used are: AKAP, A-kinase ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
58 Novel cyclic AMP signalling avenues in learning and memory
 

Summary:  ;#12;Contents Chapter 1 Introduction and aim of the thesis 9 Chapter 2 A-kinase anchoring protein 150... Chapter 4 Inhibition of PKA anchoring to A-kinase anchoring proteins impairs consolidation and facilitates... of PKA signaling through AKAPs ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
59 Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of
 

Summary:  Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide... restriction of PKA is achieved through association with A-kinase anchoring proteins (AKAPs). AKAPs represent... ) Compartmentalization of the cAMP-dependent ...

  

Source: Hogan, Brigid L.M. - Department of Cell Biology, Duke University; Scott, John D. - Department of Pharmacology, University of Washington at Seattle; Soderling, Scott - Department of Cell Biology, Duke University

 

Collection: Biology and Medicine

 
60 EXPERIMENTAL CELL RESEARCH 238, 305316 (1998) ARTICLE NO. EX973855
 

Summary:  Localization, and Cell Cycle-Dependent Subcellular Distribution of the A-Kinase Anchoring Protein, AKAP95 Turid... and scaffold proteins. Cell 85, 9­12. J. D. (1996). Mutational analysis of the A-kinase anchoring pro- tein... . J. Biol. Chem. 268, 21276­21283. ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine


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61 TIBS 17 -JULY 1992 Blotting and band-shifting:techniques
 

Summary:  -~°. Rubin and col- leagues have named these molecules A-kinase anchoring proteins (AKAPs) because... (PKA) is localized in certain cellu- lar compartments through association with specific A-kinase... anchoring proteins (AKAPs). A variety of blotting and ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
62 BioMed CentralBMC Neuroscience BMC Neuroscience2001,2 :17
 

Summary:  A (PKA) and protein kinase C (PKC). A-kinase anchoring proteins (AKAPs) can recruit both enzymes... with A- kinase anchoring proteins (AKAPs). This association en- sures specificity in signal transduction... and char- ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
63 Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex
 

Summary:  Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex Matthew G... September 28, 2010) A-kinase anchoring protein 79 (AKAP79) is a human anchoring protein that organizes c... in cellular ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
64 268s BiochemmlSoclety Transacbions (1995)23 ANALYSIS OF A NOVEL A-KINASE ANCHORING
 

Summary:  268s BiochemmlSoclety Transacbions (1995)23 ANALYSIS OF A NOVEL A-KINASE ANCHORING PROTEIN 100... via interaction of the regulatory subunit (RII) with A-Kinase Anchor Proteins (AKAPs), (11... discovery,which ultimatelylinked the action of CAMPto the then novel ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
65 DEVELOPMENTAL BIOLOGY 176, 5161 (1996) ARTICLE NO. 0114
 

Summary:  A-Kinase Anchoring Protein Qihang Zhang,*,1 Daniel W. Carr,,2 Kenneth M. Lerea,* John D. Scott... in the cartilage nuclear fraction. Furthermore, a novel Ç150-kDa A-kinase anchoring protein (AKAP), which binds... gel elec-(Theurkauf and Vallee, 1982). RII also ...

  

Source: Newman, Stuart A. - Department of Cell Biology and Anatomy, New York Medical College; Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
66 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1106711072, September 1997
 

Summary:  of A-kinase anchor proteins (AKAPs) positioned in close prox- imity to target proteins... substrates (3). In support of this, RII subunits have been shown to bind to a family of A-kinase anchor... 9411067-6$2.00 0 PNAS is available online at http: www.pnas.org. ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
67 52 Research Paper Gravin, an autoantigen recognized by serum from myasthenia
 

Summary:  kinase C. We isolated a cDNA encoding a 250 kDa A-kinase anchoring protein (AKAP) called gravin, which... through interaction of its regulatory (R) subunits with a functionally related family of 30 or so A-kinase... - anchoring proteins, called AKAPs (reviewed in ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
68 BiochemicalSociety Transactions Subcellular targeting of kinases and phosphatases by association with bifunctional
 

Summary:  the interaction of its regulatory (RII) subunit with A-kinase anchor proteins (AKAPs) [13-16]. The scope... of this paper Abbreviations used: AKAP, A-kinase anchoring protein; AMPA. a-amino-3-hydroxy-5-methyl-4-isoxazole... by association with bifunctional ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
69 The Rockefeller University Press, 0021-9525/2002/08/659/10 $5.00 The Journal of Cell Biology, Volume 158, Number 4, August 19, 2002 659668
 

Summary:  659 Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics Neal M. Alto,2... proximity to their substrates. One example is the A-kinase anchoring proteins (AKAPs)* that sequester the c... -kinase anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
70 Biochem. J. (2010) 432, 549556 (Printed in Great Britain) doi:10.1042/BJ20100936 549 PP2B/calcineurin-mediated desensitization of TRPV1 does not require
 

Summary:  regulatory components. Key words: A-kinase-anchoring protein 150 (AKAP150), calcineurin, pain... ]. AKAP150 (A-kinase-anchoring protein 150) is a scaffolding protein that organizes the phosphorylation... , K. M. (2008) A-kinase anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
71 Mutational Analysis of the A-Kinase Anchoring Protein (AKAP)-binding Site on RII
 

Summary:  Mutational Analysis of the A-Kinase Anchoring Protein (AKAP)-binding Site on RII CLASSIFICATION... subunit (RII) with A-Kinase Anchoring Proteins (AKAPs). The AKAP-binding site involves amino-ter- minal... , micro- tubule-associated protein 2; ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
72 The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain
 

Summary:  The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain Leslie A... , Wang HY, Malbon CC (2007) Src docks to A-kinase anchoring protein gravin, regulating beta 2-adrenergic... Southwestern Medical Center, Dallas, TX, and approved May 3, 2008 ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
73 Biochem. J. (2004) 381, 587592 (Printed in Great Britain) 587 ACCELERATED PUBLICATION
 

Summary:  , OR 97239-3098, U.S.A. mAKAP (muscle-selective A-kinase-anchoring protein) co-ordi- nates a c... the recruitment of PDE4D3, allowing for quicker signal termination. Key words: A-kinase-anchoring protein (AKAP... . INTRODUCTION mAKAP (muscle-selective A-kinase-anchoring ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
74 THEJOURNALOF BIOLOGICALCHEMISTRY Q 1992by The American Societyfor Biochemistry and MolecularBiology,Inc.
 

Summary:  -dependent Protein Kinase to the Postsynaptic Densities by A-KinaseAnchoring Proteins CHARACTERIZATION OF AKAP 79... renamed this family of RII-binding pro- teins asA-Kinase Anchor Proteins (AKAP 75, AKAP 79, and AKAP 150... -dependentprotein ki- nase; MAP 2, ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
75 Neuropharmacology 46 (2004) 299310 www.elsevier.com/locate/neuropharm
 

Summary:  how the compartmentalization of PKA through its association with A-Kinase Anchoring Proteins (AKAPs... AMP-dependent Protein Kinase (PKA); A-Kinase Anchoring Protein (AKAP); cAMP; Neuron; Synaptic plasticity; Learning... of PKA, ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
76 280:2038-2045, 2001.Am J Physiol Heart Circ Physiol Franck Potet, John D. Scott, Raha Mohammad-Panah, Denis Escande and Isabelle
 

Summary:  CDNA3-A kinase anchoring protein (AKAP)79. A, left: vertical bar, 500 pA; horizontal bar, 500 ms. Right... , Little BM, Langeberg LK, and Scott JD. Cloning and characterization of A-kinase anchor protein 100 (AKAP... , and Jennings PA. The ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
77 Cell Signaling in Space and Time: Where Proteins Come Together and
 

Summary:  by kinase suppressor of Ras (KSR) and JNK interacting protein (JIP). (B) A-kinase anchoring proteins (AKAPs... - strates. Prime examples remain the type 1 phos- phatase (PP1) targeting subunits and A-kinase anchoring... proteins (AKAPs). The ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
78 Entropic contributions and the influence of the hydrophobic environment in promiscuous
 

Summary:  with multiple partners, collectively referred to as A-kinase-anchoring proteins (AKAPs) that localize PKA... . (2003) Bioinformatic design of A-kinase anchoring protein in silico: A potent and selective peptide... kinase A (PKA), which uses a single face on its docking/dimeriza- tion ...

  

Source: Wang, Wei - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Chemistry ; Biology and Medicine

 
79 Biochem. J. (2006) 396, 297306 (Printed in Great Britain) doi:10.1042/BJ20051970 297 High-affinity AKAP7protein kinase A interaction yields novel protein
 

Summary:  (Washington) 295, 1711­1715 2 Langeberg, L. K. and Scott, J. D. (2005) A-kinase-anchoring proteins. J. Cell... to subcellular compartments by direct interaction of its regulatory subunits (RI or RII) with AKAPs (A kinase-anchoring... -affinity AKAP7­protein kinase A interaction yields ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
80 SUPPLEMENTARY INFORMATION Jarnss et al. "Splicing factor arginine serine rich 17A (SFRS17A) is an A-
 

Summary:  ) is an A- kinase anchoring protein that targets protein kinase A to splicing factor compartments" Protein... result from search in the International Protein Index (IPI) database. A RISR consensus sequence (L(x)3(E... Protein ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine


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81 Wednesday Seminar Series 2006-2007 4:00-5:00 PM, Conference Room K-207 (2-6408)
 

Summary:  " September 20 Dr. Joseph Miano "Biology of a Retinoid-Induced A-Kinase Anchoring Protein" September 27 Dr... During Development: A Protein Expression Profiling Approach" October 11 Open October 18 Dr. Eileen... Makes New Acquaintances" March 28 Dr. Yibin Wang (Host, Dr. Yan) "Novel ...

  

Source: Goldman, Steven A. - Division of Cell and Gene Therapy, University of Rochester

 

Collection: Biology and Medicine

 
82 Calcineurin anchoring and cell signaling Kimberly L. Dodge and John D. Scott*
 

Summary:  .D. Scott, Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares prop... , A-kinase anchoring proteins and neuronal signaling mechanisms, Genes Dev. 17 (2003) 1557­1568. [27... interaction with various ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
83 Molecular Cell 24, 383395, November 3, 2006 2006 Elsevier Inc. DOI 10.1016/j.molcel.2006.09.006 Molecular Basis of AKAP Specificity
 

Summary:  .A., and Scott, J.D. (2003). Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective... in an A-kinase anchoring protein complex, rather than a unique role in sperm-zona pellucida binding... kinase interaction with ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
84 AKAP18 Contains a Phosphoesterase Domain that Matthew G. Gold1
 

Summary:  -mail address: David.barford@icr.ac.uk. Abbreviations used: AKAP, A-kinase anchoring proteins; PKA, protein... . & Kass, R. S. (2004). Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium... ., Westphal, A. M., Dean, ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
85 Laboratoire de Combinatoire et d'Informatique Mathmatique Universit du Qubec Montral
 

Summary:  ) anchor is a C-terminal post- translational modification of proteins. Here, we investigate the problem... of correctly annotating GPI-anchored protein for thegrowing number of sequences in public databases. Like many... other protein sequence signatures, the biological rules that direct ...

  

Source: Chauve, Cedric - Department of Mathematics, Simon Fraser University

 

Collection: Mathematics

 
86 BIOINFORMATICS ORIGINAL PAPER Vol. 27 no. 13 2011, pages 18141821
 

Summary:  AMP-dependent protein kinase (PKA) and a peptide in A-kinase anchoring proteins (AKAPs) is critical for translocating... and hydrophobic surface for peptides in A-kinase anchoring proteins (AKAPs). The protein­protein ...

  

Source: Wang, Wei - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Chemistry ; Biology and Medicine

 
87 Cell Signaling I:Cell Signaling I: Sex, Drugs andSex, Drugs and
 

Summary:  including hormone synthesis. cAMP activity mediated by cAMP-dependent protein kinase (A kinase or PKA). Gs... SignalingHormone Signaling Signaling via GSignaling via G--protein coupled receptors:protein coupled... receptors: cAMPcAMP Signaling via GSignaling via ...

  

Source: Ramos, Joe W. - Cancer Research Center of Hawai'i, University of Hawai'i at Manoa

 

Collection: Biology and Medicine

 
88 www.ncmm.uio.no P.O. Box 1137, N-0318 University of Oslo, Norway Postdoctoral and PhD research fellowships
 

Summary:  AMP-signaling events coordinated by A-kinase anchoring proteins (AKAPs). The Tasken group investigates the role... of anchoring proteins in spatiotemporal regulation of signaling events and signal networks in cancer cells

  

Source: Løw, Erik - Matematisk institutt, Universitetet i Oslo

 

Collection: Mathematics

 
89 INTRODUCTION The phosphorylation of intracellular proteins is a universal
 

Summary:  that compartmentalization of the cAMP-dependent protein kinase is maintained by a family of A-kinase anchoring proteins... is tethered at specific intracellular locations through association with A-kinase anchoring proteins (AKAPs... AKAP: an ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
90 A RT I C L E S 1066 NATURE CELL BIOLOGY VOLUME 7 | NUMBER 11 | NOVEMBER 2005
 

Summary:  combinations to substrates. The A-kinase anchoring protein AKAP79/150 is a multivalent scaffolding protein... densities by A-kinase anchoring proteins: characterization of AKAP79. J. Biol. Chem. 24, 16816­16823 (1992... with scaffolding ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
91 The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
 

Summary:  AMP-responsive signalling complex maintained by the muscle- specific A-kinase anchoring protein (mAKAP) that includes PKA... by R. Tsien. A DNA fragment encoding the consensus RII binding peptide from AKAPis (A-kinase anchoring... The protein kinase A ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
92 Communication Vol. 268, No. 28, Issue of October 5,pp. 20729-20732, 1993 THE JOWALOF B I O ~ I C A LCHEMISTRY
 

Summary:  .S.A. Follicle-stimulatingHormone Regulation ofA-kinase Anchoring Proteins in Granulosa Cells* (Received... InductionofIsoform-specificA-kinaseAnchoringProteins 20731 Control" ~ ~ FSH Hours 0 4 12 24 48 72 0 4 12 24... .jbc.orgDownloadedfrom #12;20732 FSH Induction ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
93 MOLECULAR AND CELLULAR BIOLOGY, June 2004, p. 46134626 Vol. 24, No. 11 0270-7306/04/$08.00 0 DOI: 10.1128/MCB.24.11.46134626.2004
 

Summary:  /Returned for modification 3 February 2004/Accepted 25 February 2004 A-kinase anchor protein 121 (AKAP121... holoenzyme is anchored to discrete cellular compart- ments by A-kinase anchor proteins (AKAPs) (15, 20, 34... ) and its spliced isoform ...

  

Source: Ullrich, Axel - Max-Planck-Institut für Biochemie

 

Collection: Biology and Medicine

 
94 Delineation of Type I Protein Kinase A-selective Signaling Events Using an RI Anchoring Disruptor*
 

Summary:  regulation of PKA phosphorylation events is facilitated by A-kinase anchoring proteins (AKAPs). This fam- ily... dis- ruptor; scRIAD, scrambled RIAD; AKAP, A-kinase anchoring protein; cAMP, cyclic AMP; PDSM... Delineation of Type I Protein Kinase ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
95 Regulation of the AKAP79-Protein Kinase C Interaction by /Calmodulin*
 

Summary:  certain substrates (5, 6). An emerging family of proteins called AKAPs1 (A Kinase Anchoring Proteins... Institute, Oregon Health Sciences University, Portland, Oregon 97201 The A kinase-anchoring protein AKAP79... are inhibited when associated ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
96 AKAP79 and the evolution of the AKAP model Kimberley Dodge, John D. Scott*
 

Summary:  with A-kinase-anchor- ing proteins (AKAPs). Structural and functional studies have led to the development... of PKA via the association with A-kinase-an- choring proteins (AKAPs) has emerged as an important... [11]. The discovery that some AKAPs not only bind PKA but also anchor ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
97 Signaling Through Scaffold, Anchoring, and Adaptor Proteins
 

Summary:  and phosphodiesterases create gradients and compartmentalized pools of cAMP, where- as A-kinase anchoring proteins (AKAPs... Signaling Through Scaffold, Anchoring, and Adaptor Proteins Tony Pawson and John D. Scott... are activated in the cell. The role of scaffold, ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
98 Multiple Interactions within the AKAP220 Signaling Complex Contribute to Protein Phosphatase 1 Regulation*
 

Summary:  that a 220-kDa A-kinase anchoring protein (AKAP220) coordinates the location of the cAMP- dependent protein... is controlled by high affinity protein-protein interactions between the R subunit dimer and A-kinase anchoring... AMP-dependent ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
99 Copyright C Blackwell Munksgaard 2003 Traffic 2003; 4: 612
 

Summary:  with the regulatory subunit of PKA and may therefore represent a novel class of A-kinase-adaptor proteins (AKAPs) #12... . Molecular characterization of a novel A kinase anchor protein from Drosophila melanogaster. J Biol Chem 1997... : a protein kinase A-anchoring, ...

  

Source: De Lozanne, Arturo - Section of Molecular, Cell and Developmental Biology, Division of Biological Sciences, University of Texas at Austin

 

Collection: Biology and Medicine

 
100 Molecular Cell, Vol. 3, 413422, April, 1999, Copyright 1999 by Cell Press Phosphorylation and Inactivation of BAD
 

Summary:  following IL-3 addition or withdrawal dictates cell survival (Zha et al., 1996).as A-kinase-anchoring... and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A tissues and the maintenance of normal tissue... 3 amphi-type II PKA holoenzyme association with A-kinase- pathic -helical peptide from BAK ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine


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