| Sample search results for: a4 hydrolase inhibitors |
| 1 | UC Davis Partnering opportunities: Arachidonic acid pathway | ||
|
Summary: Synthase LTA4 Hydrolase 9-HETE 11-HETE 8-HETE 12-HETE Lipoxin A4 12-LOX 15-HETE (15-HODE) 15-oxo-ETE 15-LOX... hydrolase inhibitors and FLAP inhibitors. We are able to monitor eisosanoid profiles in animal models... demonstrated that inhibitors ... |
|||
|
Source: Nguyen, Danh - Department of Public Health Sciences, University of California, Davis |
|||
|
Collection: Biology and Medicine ; Mathematics |
|||
| 2 | INVITED REVIEW The Soluble Epoxide Hydrolase as a Pharmaceutical | ||
|
Summary: the carbonyl of the central pharmacophore of the urea as illustrated by the inhibitors shown in Figures 3A, 4... Words: soluble epoxide hydrolase, epoxide hydrolase, epoxide hydrolase inhibitor, inflammation... ; sEHI, soluble epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 3 | pubs.acs.org/jmcr XXXX American Chemical Society J. Med. Chem. XXXX, XXX, 000000 A | ||
|
Summary: of the R-ketoheterocycle inhibitors 3-5 bound to a humanized variant of fatty acid amide hydrolase (FAAH... of action (Figure 1A).4,14 To date, two key classesofinhibitorshavebeenpursuedthatprovideopportunities... selectivity (vs other serine hydrolases),37,38,49 and signifi- cantly ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 4 | Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo | ||
|
Summary: receptor targeted inhibitor sunitinib is a potent in- hibitor of the human soluble epoxide hydrolase... of sorafenib as a soluble epoxide hydrolase inhibitor indicate that the soluble epoxide hydrolase... -AUCB (C; B and C are potent soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 5 | Epoxide hydrolases: their roles and interactions with lipid metabolism | ||
|
Summary: , leukotriene A4 hydrolase, the microsomal epoxide hydrolase, and the insect juvenile hor- mone epoxide... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2.4. Leukotriene A4 hydrolase... ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 6 | Soluble Epoxide Hydrolase in Atherosclerosis Yi-Xin Jim Wang & Arzu Ulu & Le-Ning Zhang & | ||
|
Summary: via Gs [5], leading to membrane hyperpolarization, hence causing COX LOX P450 2C/2J sEH P450 4A/4F Fig... and related com- pounds; and 3) CYP450, form- ing epoxides (2C/2J) and 20-HETEs (4A/4F). Epoxyeico- satrienoic... F Fig. 2 Representative structures of soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 7 | Chemistry & Biology Discovery and Characterization of a | ||
|
Summary: -baseline levels by 7 hr posttreatment (Figures 4A4C). The different rates of recovery of both FAAH activity... (Figure 2A) and NAE levels (Figures 4A4C) in mice treated with PF-3845 versus URB597 likely reflect... hydrolase inhibitors with remarkable selectivity. ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 8 | Introduction The epoxyeicosatrienoic acids (EETs), products | ||
|
Summary: EH), mi- crosomal epoxide hydrolase (mEH), leukotriene A4 hydrolase, hepoxilin A3 hydrolase, and choles... of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl... , Sanborn JR and Hammock BD. ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 9 | Structure-Activity Relationships of r-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase Christophe Hardouin,, Michael J. Kelso,, F. Anthony Romero,, Thomas J. Rayl,, Donmienne Leung,, Inkyu Hwang,, | ||
|
Summary: Structure-Activity Relationships of r-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase... (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting the C2 acyl... selective for FAAH over other mammalian serine hydrolases61 and a set of irrevers- ible ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 10 | Potent and Selective r-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase | ||
|
Summary: ), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targeting the 5-position... selective for FAAH over other mammalian serine hydrolases62 and a set of irreversible inhibitors48... not significantly inhibit the common P450 metabolism enzymes ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 11 | Soluble Epoxide Hydrolase Inhibitors and Heart Failure Jun-Yan Liu,3 | ||
|
Summary: REVIEW Soluble Epoxide Hydrolase Inhibitors and Heart Failure Hong Qiu,1 Ning Li,1 Jun-Yan Liu,3... ; Epoxyeicosatrienoic acids (EETs); Heart failure; Soluble epoxide hydrolase inhibitors. Correspondence Nipavan... . Qiu et al. Soluble Epoxide Hydrolase Inhibitors in ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 12 | [161 EPOXIDEHYDROLASES 303 consumption and related hormonal events, rather than photoperiod, are | ||
|
Summary: for at least four forms of epoxide hydrolase in verte- brate systems. One of these forms hydrates leukotriene A... ~p. Biol. 43, 1719(1984). [16] Epoxide Hydrolases in the Catabolism of Sterols and Isoprenoids By BRUCE D... . HAMMOCK, DAVID E. MOODY, and ALEX SEVANIAN Background Information Epoxide hydrolases ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 13 | Chemistry & Biology A Comprehensive Profile of Brain Enzymes | ||
|
Summary: Profile of Mouse Brain 2-AG Hydrolases #12;residues by the NAM inhibitor) (Figure 5A; Figure S3). THL (20... of inhibitors on the 2-AG hydrolase activity of brain-membrane preparations. Con- sistent with previous studies... min) to block MAGL activity. (E) Effects of inhibitors on total ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 14 | This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the | ||
|
Summary: serine hydrolase inhibitors, a custom-synthesised inhibitor, 10-(fluoro- ethoxyphosphinyl... "elbow" on the sharp turn between strand b-F and helix a-4, with this strained geometry typical... of the Active site of the Serine Esterase S-Formylglutathione Hydrolase Ian ... |
|||
|
Source: Davis, Ben G. - Department of Chemistry, University of Oxford |
|||
|
Collection: Chemistry |
|||
| 15 | pubs.acs.org/jmc Published on Web 11/11/2010 r 2010 American Chemical Society 8376 J. Med. Chem. 2010, 53, 83768386 | ||
|
Summary: including leukotriene A4 hydrolase, cho- lesterol epoxide hydrolase,2 hepoxilin hydrolase,3 microsomal... ,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase... ortho 28a 3 CH3CO 990 25.2 ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 16 | Annu. Rev. Pharmacol. Toxicol. 2005. 45:31133 doi: 10.1146/annurev.pharmtox.45.120403.095920 | ||
|
Summary: on September 22, 2004 EPOXIDE HYDROLASES: Mechanisms, Inhibitor Designs, and Biological Roles Christophe... al. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation... of California, Davis, California 95616; email: bdhammock@ucdavis.edu Key Words ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 17 | Biochemical Pharmacology, Vol.30, No. 15,pp.2111-2120,1981 Printedin Great Britain. | ||
|
Summary: hydrolase, also serve as good inhibitors of the mitochondrial epoxide hydrolase. DISCUSSION The results... .?952:81!152111-IO$02.0010 0 19RlPergamon PressLtd. EPOXIDE HYDROLASE ACTIVITY IN THE MITOCHONDRIAL... October 1980; accepted 16 January 1981) Abstract-Distribution of epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 18 | CLAN CA C1B 372. Bleomycin hydrolase 1197 372. Bleomycin hydrolase | ||
|
Summary: is a weak inhibitor for the yeast and rat enzymes but has no effect on the human bleomycin hydrolase... CLAN CA C1B 372. Bleomycin hydrolase 1197 372. Bleomycin hydrolase Databanks MEROPS name... : Bleomycin hydrolase (animal) MEROPS classification: clan CA, family C1B, peptidase ... |
|||
|
Source: Joshua-Tor, Leemor - W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory |
|||
|
Collection: Biology and Medicine |
|||
| 19 | Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease | ||
|
Summary: epoxide hydrolase (sEH) and sEH inhibitors are considered treatment for chronic renal failure (CRF). We... . In contrast, 12-HETE and the Cyp450a4- product 20-HETE were unaffected in this scenario, excluding... , Zaharis CZ, Olearczyk JJ, Pollock DM, et al. (2005) An orally active epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 20 | doi:10.1152/ajpendo.00710.2010 300:E691-E698, 2011. First published 25 January 2011;Am J Physiol Endocrinol Metab | ||
|
Summary: , lipoxygen- ase, and cyclooxygenase pathways. hypertension; soluble epoxide hydrolase inhibitors; perinatal... .01 vs. 2 wk). 8-hydroxyeicosatetraenoic acid (8- HETE) also increased with age. Lipoxin A4 (LXA4), throm... . An epoxide hydrolase inhibitor, ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 21 | DIFFERENTIAL SUBSTRATE SELECTIVITY OF MURINE HEPATIC CYTOSOLIC AND MICROSOMAL EPOXIDE | ||
|
Summary: to be reasonable inhibitors of the cytosolic epoxide hydrolase, indicating that the structural requirements... epoxide hydrolase. Fat instance. the best inhibitor, tmns-stilbene oxide. has a K, of 1 x lo-`M compared... . Trichloropropene oxide (16) has been widely used as an inhibitor of ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 22 | Exploration of a fundamental substituent effect of a-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase | ||
|
Summary: and selective inhibitors of fatty acid amide hydrolase Jessica K. DeMartino, Joie Garfunkle, Dustin G... -ketooxazoles were examined as inhibitors of the serine hydrolase fatty acid amide hydrolase in efforts that further... Li Scheme 1. H Br Cl I CH3 SCH3 CHO COCH3 CF3CO CO2CH3 48 3.0 4.0 ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 23 | General introduction into Nudix hydrolase proteins General introduction into Nudix hydrolase proteins | ||
|
Summary: 11 Chapter 1 General introduction into Nudix hydrolase proteins #12;12 #12;General introduction... into Nudix hydrolase proteins 13 Different chemical and physical forces constantly threaten the integrity... ). The MutT or Nudix hydrolase protein family In an amino acid comparison of the E. coli MutT sequence |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 24 | Profiling Serine Hydrolase Activities in Complex Proteomes Dana Kidd, Yongsheng Liu, and Benjamin F. Cravatt* | ||
|
Summary: hydrolase inhibitors directly in complex proteomes. Finally, a general method for the avidin-based affinity... selectivity of reversible serine hydrolase inhibitors directly in complex proteomes, and (iii) isolate... Vity of ReVersible Serine Hydrolase Inhibitors in ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 25 | FEBS Letters 338 (1994) 251-256 Sequence similarity of mammalian epoxide hydrolases to the bacterial | ||
|
Summary: acetyltransferdse hpase magnesmm chelatase luciferase bromoperoxldase leukotnene A4 hydrolase Rattus norvegicus... of mammalian epoxide hydrolases to the bacterial haloalkane dehalogenase and other related proteins Implication... and soluble epoxlde hydrolase superficially mdlcates that ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 26 | Human soluble epoxide hydrolase: Structural basis of inhibition by | ||
|
Summary: epoxide hydrolase. (B) General binding mode of a dialkylurea inhibitor, which mimics the transition state... . Data from Kim et al. 2004. Table 1. Epoxide hydrolase inhibitors www.proteinscience.org 59 Human... epoxide hydrolaseinhibitor complexes #12;inhibitor ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 27 | MOLECULAR, CELLULAR, AND DEVELOPMENTAL BIOLOGY The Cloning and Characterization of a Soluble Epoxide Hydrolase in Chicken | ||
|
Summary: EPOXIDE HYDROLASE IN CHICKEN 279 thelial cells using an sEH inhibitor (Fang et al., 2001). In vivo... ;CHARACTERIZATION OF A SOLUBLE EPOXIDE HYDROLASE IN CHICKEN 285 Figure 4. IC50 values for the urea-based inhibitors... . Hammock. 2005. Epoxide hydrolases: Mechanisms, ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 28 | Introduction Amidohydrolases | ||
|
Summary: -peptide amidohydrolases is formed by the serine hydrolases; it makes use of a nucleophilic serine that attacks... the scissile amide bond. A classic catalytic scaffold for serine-hydrolases consists of a catalytic triad... in chymotrypsin by Blow et al. (1969), and similar catalytic triads were found later in other peptide ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 29 | Inhibitor SourceBookTM Your #1 Resource for Quality Inhibitors | ||
|
Summary: Inhibitor SourceBookTM Your #1 Resource for Quality Inhibitors Includes inhibitors... /Dephosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 Akt (Protein Kinase B) Inhibitors... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... |
|||
|
Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem |
|||
|
Collection: Biotechnology ; Biology and Medicine |
|||
| 30 | Inactivation of epoxide hydrolase by vicinal diols | ||
|
Summary: . Vicinal diols are competitive inhibitors of this epoxide hydrolase (Baldascini et al., 2001). During... ;Chapter 4 since at high concentrations it is a competitive inhibitor of epoxide hydrolase. Conversion... , a strong inhibitor of epoxide hydrolase, was tested by ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 31 | Comp. Biochem.Physiol.Vol. 87B,No. 1, pp. 95-102, 1987 0305-0491/87 $3.00+ 0.00 Printed in Great Britain 1987PergamonJournalsLtd | ||
|
Summary: -5881. McGee J. and Fitzpatrick F. (1985) Enzymatichydration of lenkotrine A4. J. biol. Chem. 260, 12832... Britain © 1987PergamonJournalsLtd AFFINITY PURIFICATION OF CYTOSOLIC EPOXIDE HYDROLASE FROM HUMAN, RHESUS... 1986) Abstract--1. An affinity purification system based on elution of cytosolic epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 32 | Inhibition of Microsomal Epoxide Hydrolases by Ureas, Amides, and Amines | ||
|
Summary: if it is used as a mEH inhibitor. We recently developed new inhibitors for the soluble epoxide hydrolase (s... ) 1,2-Epoxycyclo- alkanes: substrates and inhibitors of microsomal and cytosolic epoxide hydrolases... of potent inhibitors of human microsomal epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 33 | Summary and concluding remarks In this chapter the main findings of the work described in this thesis, | ||
|
Summary: of diols on epoxide hydrolase activity Vicinal diols are competitive inhibitors of epoxide hydrolase. We... an epoxide hydrolase originally isolated from the organism Agrobacterium radiobacter AD1 (van den Wijngaard... . Inactivation of epoxide hydrolase was found to be caused by direct ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 34 | Integrative Physiology Redox Regulation of Soluble Epoxide Hydrolase by | ||
|
Summary: is a sEH inhibitor using an established epoxide hydrolase spectrophotometric activity assay. These s... distinct pharmacological inhibitors of this hydrolase (AUDA or t-AUCB) themselves indepen- dently induced... These past inconsistencies along with the fact that hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 35 | Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble | ||
|
Summary: levels, the hydrolase domain lowered cholesterol levels. Hydrolase inhibitor treatment ins... hydrolase inhibitor- treated male and female sEH-WT mice as compared with sEH-KO. n four animals... mechanisms. For example, the effect of the hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 36 | Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling | ||
|
Summary: Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein... -based proteomics Biosynthesis Endocannabinoid Inhibitor Lipase a b s t r a c t The endocannabinoid 2... on pharmacological studies using inhibitors of the 2-AG biosynthetic enzymes diacyglycerol lipase a and b (DAGL |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 37 | Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system | ||
|
Summary: -tissue proteomes, FAAH inhibitors were tested for their ability to slow the rate of labeling of serine hydrolases... : Bisarylimidazolyl fatty acid amide hydrolase inhibitors. Patent application W0 02/087569, 2002. This patent... Fatty acid amide hydrolase: an emerging therapeutic target ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 38 | Protease Inhibitors -Application Table Protease Inhibitors -Application Table | ||
|
Summary: ) and leucine aminopeptidase. Inhibitor of leukotriene A4 hydrolase and of enkephalin degradation in cell... Protease Inhibitors - Application Table Protease Inhibitors - Application Table The following table... gives an overview on the use and application of ... |
|||
|
Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem |
|||
|
Collection: Biotechnology ; Biology and Medicine |
|||
| 39 | Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders | ||
|
Summary: the name fatty acid amide hydrolase (FAAH) (5). Another prominent substrate-derived inhibitor is MAFP (6... irreversible inhibitor of FAAH and several other serine hydrolases (52,63,64). As described in section 7... , activity- based probes to profile the proteomic selectivity of FAAH ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 40 | Current Pharmaceutical Biotechnology, 2009, 10, 589-599 589 1389-2010/09 $55.00+.00 2009 Bentham Science Publishers Ltd. | ||
|
Summary: epoxide hydrolase, tryptophan fluorescence quenching, enzyme inhibitors, inhibitor detection. INTRODUCTION... hydrolases: mechanisms, inhibitor designs, and biological roles. Ann. Rev. Pharmacol. Toxicol., 45, 311... - lurea inhibitors to epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 41 | Many of the enzymes, receptors and eicosanoid metabo-lites of the arachidonate cascade (FIG. 1) are key thera- | ||
|
Summary: of hypertension. Figure 2 | soluble epoxide hydrolase inhibitor (seHi) structures and binding to the enzymatic... | Antihypertensive and end-organ protective actions of soluble epoxide hydrolase inhibitors (seHis). a | The increase... -inflammatory drugs (NSAIDs), including inhibitors of ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 42 | Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity | ||
|
Summary: Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity... of serine hydrolase inhibitors including fluorophosphonates (21), trifluoromethyl ketones (22), R... a global view of the proteome-wide selectivity of serine hydrolase ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 43 | Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented | ||
|
Summary: Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence... for evaluating the potency and selectivity of serine hydrolase inhibitors in whole proteomes (Leung et al., 2003... )] determined by activity-based protein profiling for serine hydrolases sensitive to ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 44 | Structural Characterization of Enterobactin Hydrolase IroE, N. A. Larsen, H. Lin,, R. Wei, M. A. Fischbach,,| and C. T. Walsh*, | ||
|
Summary: fluorophosphonate (DFP, a potent serine hydrolase inhibitor) were determined at 2.3 and 1.4 Å resolution... the ferric ion into the cytoplasm (Figure 2A) (4). Despite the high affinity of Ent for iron, the efficiency... Articles Structural Characterization of Enterobactin Hydrolase IroE, ... |
|||
|
Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University |
|||
|
Collection: Biology and Medicine |
|||
| 45 | Identification of the catalytic residues of -amino acid ester hydrolase from Acetobacter turbidans by labeling and site- | ||
|
Summary: aminopeptidase. The serine hydrolase inhibitor p-nitrophenyl-p' -guanidino- benzoate appeared to be an active... of a histidine for the catalytic activity of AEH (Ryu and Ryu, 1988). However, common serine hydrolase inhibitors... with the serine hydrolase inhibitor ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 46 | Prostaglandins & other Lipid Mediators 82 (2007) 4249 Soluble epoxide hydrolase inhibition reveals novel biological | ||
|
Summary: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Abbreviations: EET, epoxyeicosatrienoic acid; sEH, soluble epoxide hydrolase; sEHI, sEH inhibitors... 1995;270:796874. [18] Morisseau C, Hammock BD. Epoxide hydrolases: mechanisms, inhibitor ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 47 | pubs.acs.org/jmcPublished on Web 09/02/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 70677075 7067 | ||
|
Summary: relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1... by soluble epoxide hydrolase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 1873318738. (9) Morisseau... , C.; Hammock, B. D. Epoxide hydrolases: mechanisms, ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 48 | Structure-guided inhibitor design for human FAAH by interspecies active site conversion | ||
|
Summary: hydrolase inhibitors [e.g., trifluoromethyl ketones (23, 24), flu- orophosphonates (25), -ketoheterocycles... to other lipid hydrolases. More recently, FAAH inhibitors with greatly improved selectivity have been... to determine the crystal structure of FAAH in complex with the general serine ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 49 | The Putative Endocannabinoid Transport Blocker LY2183240 Is a Potent Inhibitor of FAAH and Several Other Brain Serine | ||
|
Summary: 2183240 Is a Potent, Covalent Inhibitor of FAAH and Several Other Brain Serine Hydrolases. In the original... of heterocyclic ureas as inhibitors of serine hydrolases, including peptidases31 and hormone-sensitive li- pase.32... ) screen, the selectivity of an inhibitor for members of the ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 50 | Chemistry & Biology Characterization of Monoacylglycerol Lipase | ||
|
Summary: by Irreversible Active-Site Carbamoylation Carbamate inhibitors typically inactivate serine hydrolases... Da, JZL184-sensitive band by gel-based ABPP in every tissue proteome analyzed (Figures 4A4I). In brain... .05) of AEA in any of the tissues in this analysis (Figures ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 51 | Discovery of a Potent, Selective, and Efficacious Class of Reversible r-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as | ||
|
Summary: (() are provided in Supporting Informa- tion. Inhibitors of Fatty Acid Amide Hydrolase Journal of Medicinal... the serine hydrolase superfamily applicable to defining the selectivity of FAAH inhibitors was developed.42... profiling of the inhibitors against all proteome serine ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 52 | BIOCHEMISTRY Analytical Biochemistry 355 (2006) 7180 | ||
|
Summary: epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt... epoxide hydrolase inhibitor, Proc. Natl. Acad. Sci. USA 102 (2005) 21862191. [11] X. Zhao, T. Yamamoto, J... , An epoxide hydrolase inhibitor, 12-(3-adamantan-1- ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 53 | Published: October 19, 2010 r 2010 American Chemical Society 2816 dx.doi.org/10.1021/jf102559q |J. Agric. Food Chem. 2011, 59, 28162824 | ||
|
Summary: hydrolase inhibitors joined samples of EETs being delivered to laboratories around the world. An early... . Epoxide hydrolases: mechan- isms, inhibitor designs, and biological roles. Annu. Rev. Pharmacol. Toxicol... . R.; Hammock, B. D. Potent urea and carbamate inhibitors of soluble ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 54 | Original article Pharmacophore-based virtual screening and Bayesian model for the identification | ||
|
Summary: of potential human leukotriene A4 hydrolase inhibitors Sundarapandian Thangapandian, Shalini John, Sugunadevi... screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors... ... |
|||
|
Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University |
|||
|
Collection: Biotechnology ; Biology and Medicine |
|||
| 55 | Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and s-adenosyl methionine provide neuroprotection against multiple consequences of | ||
|
Summary: , including the S-adenosyl homocysteine hydrolase inhibitor, 3-deaza adenosine, the methyl donor S |
|||
|
Source: Graves, Michael V. - Department of Biological Sciences, University of Massachusetts at Lowell |
|||
|
Collection: Biology and Medicine |
|||
| 56 | Diversity of serine hydrolase activities of unchallenged and Botrytis-infected Arabidopsis thaliana | ||
|
Summary: moiety in the broad-range serine hydrolase inhibitor DFP (diisopropyl fluorophosphonate). When used... plants. FP profiling can also be used to select for specific inhibitors of serine hydrolases. Specific... of serine hydrolases with reactive phosphonate inhibitors. ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 57 | Development of Metabolically Stable Inhibitors of Mammalian Microsomal Epoxide Hydrolase | ||
|
Summary: Development of Metabolically Stable Inhibitors of Mammalian Microsomal Epoxide Hydrolase Christophe... ) KI of 430 ( 70, 72 ( 5, and 118 Inhibitors of Mammalian Microsomal Epoxide Hydrolase Chem. Res... determination of soluble epoxide hydrolase inhibitors in rat ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 58 | Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase | ||
|
Summary: and a larger C-terminal which processes classical a/b-hydrolase activity.12,13 sEH inhibitors act through inhi... with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci USA 2005;102:21862191. 12. Newman JW, Morisseau C... , Hammock BD. Orally bioavailable potent soluble epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 59 | Biochemical Evidence for the Involvement of Tyrosine in Epoxide Activation during the Catalytic Cycle of Epoxide Hydrolase* | ||
|
Summary: , wild-type (2.5 g); lane 2, Y381F (1.3 g); lane 3, Y465F (2.5 g); lane 4, Y465A (4.5 g); lane 5, Y381F... Cycle of Epoxide Hydrolase* Received for publication, February 22, 2000, and in revised form, May 3... , Pennsylvania 19104-6323 Epoxide hydrolases (EH) catalyze the hydrolysis of epoxides and arene ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 60 | Polymorphisms in Human Soluble Epoxide Hydrolase BEATA D. PRZYBYLA-ZAWISLAK, PUNIT K. SRIVASTAVA, JOHANA V AZQUEZ-MATIAS, HARVEY W. MOHRENWEISER, | ||
|
Summary: A4 hydrolase, cholesterol EH, and microsomal EH), which differ in molec- ular weight, subcellular... , Hammock BD, and Christian- son DW (2000) Binding of alkylurea inhibitors to epoxide hydrolase implicates... Polymorphisms in Human Soluble Epoxide Hydrolase BEATA D. ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 61 | Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis, | ||
|
Summary: inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation, J. Biol. Chem. 275... and carbamate inhibitors of soluble epoxide hydrolases, Proc. Natl. Acad. Sci. U.S.A. 96, 8849-8854. 34. Mc... ) Structural refinement of inhibitors of urea-based soluble ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 62 | Chemical Strategies for Functional Proteomics* Gregory C. Adam, Erik J. Sorensen, and Benjamin F. Cravatt | ||
|
Summary: - ine hydrolases sensitive to trifluoromethyl ketone inhibitors of fatty acid amide hydrolase... of a mechanism-based reactive group (a 4-fluoromethyl-1-phosphophenyl substituent (50)), a diethyl- ene glycol... that target, for example, serine hydrolases (29, 30) and ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 63 | A novel meta-cleavage product hydrolase from Flavobacterium sp. Syed Khajamohiddin a | ||
|
Summary: A novel meta-cleavage product hydrolase from Flavobacterium sp. ATCC27551 Syed Khajamohiddin... open-read- ing frame, orf243. This was predicted to encode an a/b hydrolase distantly related... to the meta-fission product (MFP) hydrolases such as XylF, PhnD, and CumD. By homology modeling Orf243 has |
|||
|
Source: Merrick, Mike - Department of Molecular Microbiology, John Innes Centre |
|||
|
Collection: Biology and Medicine |
|||
| 64 | Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects | ||
|
Summary: serine hydrolase inhibitors that block MAGL (along with several other enzymes, including FAAH... -based proteomic methods to broadly evaluate and optimize the selectivity of inhibitors across the serine hydrolase... 184 The pursuit of selective inhibitors for serine ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 65 | Enantioselective Biocatalytic Conversions of Epoxides | ||
|
Summary: hydrolase (mEH), soluble epoxide hydrolase (sEH), cholesterol epoxide hydrolase, leukotriene A4 epoxide... . Ik wil Rick, Jaap en Bert (epoxide hydrolase), Johan, Lixia en Ghannia (haloalcohol dehalogenase... hydrolase discussions. Yvonne Genzel ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 66 | Crystal structure of carboxylesterase from Pseudomonas fluorescens, an a/b hydrolase with broad substrate specificity | ||
|
Summary: and inhibitor- bound structures. Conclusions: Carboxylesterase from P. fluorescens has the / hydrolase fold... hydrolase inhibitors such as phenylmethylsul- fonyl fluoride (PMSF). This is consistent with the pres- ence... with the inhibitor PMSF. Each subunit of the enzyme has the / ... |
|||
|
Source: Suh, Se Won - School of Chemistry, Seoul National University |
|||
|
Collection: Chemistry ; Biotechnology |
|||
| 67 | DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism | ||
|
Summary: -CdR treatment in a dose-dependent manner (Fig. 2A); 4 M 5-Aza-CdR switched most methylated sites to unmethylated... competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase... DNA methylation of the promoter of soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 68 | Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid | ||
|
Summary: . hydrolase inhibitor metabolism N-arachidonoyl ethanolamine (anandamide or AEA) (1) and 2... agonists and endocannabinoid hydrolase inhibitors are potentially exciting from a therapeutic perspective... -selective inhibitor JZL184, and dual FAAH-MAGL inhibitors. (B) ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 69 | Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate Activation* | ||
|
Summary: Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate... The structures of two alkylurea inhibitors complexed with murine soluble epoxide hydrolase have been deter- mined... 381 is conserved among the soluble epoxide hydrolases. In one ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 70 | Lipid Sulfates and Sulfonates Are Allosteric Competitive Inhibitors of the N-Terminal Phosphatase Activity of the Mammalian Soluble Epoxide Hydrolase | ||
|
Summary: . Morisseau, C., and Hammock, B. D. (2005) Epoxide hydrolases: mechanisms, inhibitor designs and biological... ) Potent urea and carbamate inhibitors of soluble epoxide hydrolases, Proc. Natl. Acad. Sci. U.S.A. 96... Lipid Sulfates and Sulfonates Are Allosteric Competitive Inhibitors of the ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 71 | Structural renement of inhibitors of urea-based soluble epoxide hydrolases | ||
|
Summary: Structural re®nement of inhibitors of urea-based soluble epoxide hydrolases Christophe Morisseaua... . Keywords: Epoxide hydrolase; Blood pressure; Immune response; Urea inhibitors; Structure... JR, Hammock BD. Potent urea and carbamate inhibitors of soluble epoxide ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 72 | Interfacial inactivation of epoxide hydrolase in a two-liquid-phase system | ||
|
Summary: concentrations it is a competitive inhibitor of epoxide hydrolase. Conversion curves were either numerically... Chapter 3 Interfacial inactivation of epoxide hydrolase in a two-liquid-phase system Abstract... Enantioselective epoxide hydrolases are useful biocatalysts for the preparation of enantiopure ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 73 | Activity-based protein profiling: The serine hydrolases Yongsheng Liu, Matthew P. Patricelli, and Benjamin F. Cravatt* | ||
|
Summary: probe for serine hydrolases. Powers and colleagues had generated isocoumarin inhibitors coupled... to biotin as serine hydrolase inhibitors (19, 20). Al- though these isocoumarins reacted with a greater... hydrolase (FAAH) (24). As expected, FP-biotin behaved as a potent irreversible ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 74 | doi:10.1152/ajprenal.00098.2009 297:740-748, 2009. First published Jun 24, 2009;Am J Physiol Renal Physiol | ||
|
Summary: , and the sEH inhibitors inhibit the epoxide hydrolase activity of the C-terminal domain without affecting... . To determine that renal protection resides within the hydrolase domain of the Ephx2 gene, sEH inhibitor studies... / DOCA-salt mice were treated with tAUCB, a sEH inhibitor that ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 75 | Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension | ||
|
Summary: epoxide hydrolase regulation in Ang II hypertension and the ability of epoxide hydrolase inhibitors... in the same manner. Following the measurement of blood pressure, the epoxide hydrolase inhibitors (3 mg/d IP... injection of epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 76 | The -amylase family: Transglycosylation and Hydrolysis Reaction Specificity | ||
|
Summary: /hydrolysis specificity of -amylase family enzymes, as this distance is larger in a maltosyltransferase (a 4--gluca... distinct reaction specificities. The maltosyltransferase (a 4--glucanotransferase) from Thermotoga maritima... by a large collection of enzymes involved in carbohydrate processing. Glycoside ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 77 | Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) | ||
|
Summary: Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma... Available online 6 February 2010 Keywords: Hydrolase Inhibitor Screening Proteomics a b s t r a c t We... hydrolases,8,9 of our most potent inhibitor 18 to potentially further ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 78 | S P O T L I G H T O N H E A R T F A I L U R E T R A N S L A T I O N A L R E S E A R C H George W. Booz, PhD | ||
|
Summary: by application of soluble epoxide hydrolase (sEH) inhibitors in a murine MI model. 20-Hydroxyeicosatetraenoic... therapeutic aspects of soluble epoxide hydrolase inhibitors. Cardiovasc Drug Rev. 2006;24:169188. 34 Larsen... , Davis BB, Tsai HJ, et al. Soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 79 | 0 1993 hy The American Society for Biochemistry and Molecular Biology, Inc. THEJOURNALOF BIOLOGICALCHEMISTRY Vol. 268, No. 23, Issue of August 15, pp. 17628-17633, 1993 | ||
|
Summary: - ceeds by a different mechanism than that of the sEH and is very specific for leukotrieneA4... and Expressionof Murine Liver Soluble Epoxide Hydrolase* (Received for publication, March 2, 1993) David F. Grant... prepared and used to isolate the coding sequence for soluble epoxide hydrolase. A 1668-base pair ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 80 | RESEARCH PAPER Pharmacokinetic optimization of four soluble | ||
|
Summary: RESEARCH PAPER Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use... of California, Davis, CA, USA Background and purpose: Early soluble epoxide hydrolase inhibitors (s... , pharmacokinetic; sEH, soluble epoxide hydrolase; sEHI, sEH ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 81 | RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia | ||
|
Summary: RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia David J... -associated serine hydrolase that displays elevated activity in pancreatic carcinomas. Whereas RBBP9 is expressed... unknown role for a serine hydrolase in cancer biology. Conversely, loss of endogenous RBBP9 or expression |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 82 | Biochemical Characterization -Amino Acid Ester Hydrolases | ||
|
Summary: Biochemical Characterization of -Amino Acid Ester Hydrolases #12;The cover picture... is a photomicrograph of amoxicillin crystals, one of the antibiotics the -amino acid ester hydrolases can make... ;Rijksuniversiteit Groningen Biochemical Characterization of -Amino Acid Ester Hydrolases Proefschrift ter |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 83 | doi:10.1152/ajpheart.00543.2009 298:795-806, 2010. First published Dec 24, 2009;Am J Physiol Heart Circ Physiol | ||
|
Summary: , Hammock BD, Weiss RH. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell... , Hammock BD, Imig JD. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ure- ido)dodecanoic acid (AUDA... urea-derived soluble epoxide hydrolase inhibitors. J ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 84 | EVOLUTION OF ENANTIOSELECTIVITY SELECTION OF IMPROVED HYDROLASE VARIANTS | ||
|
Summary: EVOLUTION OF ENANTIOSELECTIVITY SELECTION OF IMPROVED HYDROLASE VARIANTS #12;#12;RIJKSUNIVERSITEIT... GRONINGEN Evolution of Enantioselectivity Selection of Improved Hydrolase Variants Proefschrift ter... : Directed evolution of Bacillus subtilis lipase A using enantiomeric phosphonate inhibitors: crystal |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 85 | Vascular localization of soluble epoxide hydrolase in the human kidney Zhigang Yu,1 | ||
|
Summary: Vascular localization of soluble epoxide hydrolase in the human kidney Zhigang Yu,1 Benjamin B... L. Kroetz, and Robert H. Weiss. Vascular localization of soluble epoxide hydrolase in the human... proliferation, and inflammation. Epoxyeicosatrienoic acids are converted by soluble epoxide hydrolase |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 86 | Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies | ||
|
Summary: and carbamate inhibitors of soluble epoxide hydrolases, Proc. Natl. Acad. Sci. USA 96 (1999) 88498854. [15] C... of inhibitors of urea-based soluble epoxide hydrolases, Biochem. Pharmacol. 63 (2002) 15991608. [16] Y... Fluorescent substrates for soluble epoxide hydrolase and ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 87 | A putative novel alpha/beta hydrolase ORFan family in Bacillus Naomi Siewa,b | ||
|
Summary: in the templatesÕ sequences that have no matching sequence in Banthracis were omitted: the beginning of a4, the end... . Additional elements are marked with an apostrophe (a b strand after b3 and an a helix after a4). The multiple... A putative novel alpha/beta hydrolase ORFan family in ... |
|||
|
Source: Fischer, Daniel - Center of Excellence in Bioinformatics and Life Sciences & Department of Computer Science and Engineering, State University of New York at Buffalo |
|||
|
Collection: Computer Technologies and Information Sciences ; Biotechnology ; Biology and Medicine |
|||
| 88 | This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research | ||
|
Summary: , Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase, Chem. Res. Toxicol... 's personal copy Development of fluorescent substrates for microsomal epoxide hydrolase and application... epoxide hydrolase Fluorescent substrate a-Cyanocarbonate Xenobiotic metabolism a b s t r a ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 89 | Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*S | ||
|
Summary: of leukotriene A4 hydrolase/aminopeptidase, which belongs to the same family as APN (32). Leukotriene A4... and Optimal Inhibitors*S Received for publication,August 27, 2009, and in revised form, November 10, 2009... inhibitors, and more ... |
|||
|
Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University |
|||
|
Collection: Biology and Medicine |
|||
| 90 | ORIGINAL ARTICLE Inhibition of Soluble Epoxide Hydrolase by trans-4- | ||
|
Summary: by soluble epoxide hydrolase (sEH). To study the effects of pharmacological inhibitor of sEH (sEHi), C57BL6... ;295: H2128H2134. 16. Morisseau C, Hammock BD. Epoxide hydrolases: mechanisms, inhibitor designs... . Li J, Carroll MA, Chander PN, et al. Soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 91 | Molecular Docking and Pharmacophore Filtering in the Discovery of Dual-Inhibitors for Human Leukotriene A4 Hydrolase and Leukotriene C4 Synthase | ||
|
Summary: A4 hydrolase inhibitor in comparison with the 5-lipoxy- genase inhibitor Zileuton. J. Pharmacol. Exp... Leukotriene A4 Hydrolase and Leukotriene C4 Synthase Sundarapandian Thangapandian, Shalini John, Sugunadevi... structure ... |
|||
|
Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University |
|||
|
Collection: Biotechnology ; Biology and Medicine |
|||
| 92 | Attenuation of Vascular Smooth Muscle Cell Proliferation by 1-Cyclohexyl-3-dodecyl Urea Is Independent of Soluble | ||
|
Summary: of their regulatory enzyme, soluble epoxide hydrolase (sEH), can mimic these effects. For this reason, sEH inhibitors... epoxide hydrolase inhibitor. Proc Natl Acad Sci USA 102:2186 2191. Sun J, Sui X, Bradbury JA, Zeldin DC... Is Independent of Soluble Epoxide Hydrolase Inhibition ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 93 | The Crystal Structure of the Hydrolase Domain of 10-Formyltetrahydrofolate Dehydrogenase | ||
|
Summary: The Crystal Structure of the Hydrolase Domain of 10-Formyltetrahydrofolate Dehydrogenase MECHANISM... biosynthesis, to tetrahydrofolate. The protein com- prises two functional domains: a hydrolase domain... - zyme, we have determined the crystal structure of the hydrolase domain of FDH from rat, solved to 2.3-Å |
|||
|
Source: Davies, Christopher - Department of Biochemistry and Molecular Biology, Medical University of South Carolina |
|||
|
Collection: Biology and Medicine |
|||
| 94 | Insect Biochemistry and Molecular Biology 32 (2002) 17411756 www.elsevier.com/locate/ibmb | ||
|
Summary: and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta... 2002 Abstract A new class of inhibitors of juvenile hormone epoxide hydrolase (JHEH) of Manduca sexta... epoxide hydrolases. The best inhibitors against ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 95 | Synthesis of New Carboxylesterase Inhibitors and Evaluation of Potency and Water Solubility | ||
|
Summary: aluminum hydride (1.85 mmol, 3.7 mL) was added to a stirred solution of 2a (4.0 mmol, 1.02 g) in diethyl... .46 4a 6.63 1b 1.17 4b 4.34 2a 4.51 5a 2.91 2b 2.23 5b 0.62 3a 5.57 JH IIIb 4.35 3b 3.28 a Clog... Articles Synthesis of New Carboxylesterase Inhibitors and Evaluation of Potency and ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 96 | QSAR and Classification of Murine and Human Soluble Epoxide Hydrolase Inhibition by Urea-Like Compounds | ||
|
Summary: and Predicted log IC50 (µM) Values and Predicted Class Labels for Soluble Epoxide Hydrolase Inhibitors no. seta... murine cls. calcde 1 3,4 Aldrich N/A x - N/A - 2 3,4 Aldrich N/A x - N/A - 3 3,4 Aldrich N/A x - N/A - 4... quantitative model (human soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 97 | Stable and enantioselective cross-linked epoxide hydrolase crystals | ||
|
Summary: . It is possible that co-cross-linking with a competitive 112 #12;Cross-linked epoxide hydrolase crystals inhibitor... Chapter 5 Stable and enantioselective cross-linked epoxide hydrolase crystals Abstract... In this chapter the formation and application of cross-linked crystals of epoxide hydrolase to the ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
|||
|
Collection: Biology and Medicine ; Environmental Sciences and Ecology |
|||
| 98 | Chemical Biology ()-FR182877 Is a Potent and Selective Inhibitor | ||
|
Summary: for serine hydrolases[29] and can been used to evaluate the potency and selectivity of inhibitors that target... of lactone natural products serving as inhibitors of serine hydrolases are known. For example, lipstatin... and selective inhibitors of many members of the serine ... |
|||
|
Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute |
|||
|
Collection: Biology and Medicine |
|||
| 99 | Published: February 21, 2011 r 2011 American Chemical Society 1752 dx.doi.org/10.1021/jm101431v |J. Med. Chem. 2011, 54, 17521761 | ||
|
Summary: of Cycloalkylamide Derivatives as Inhibitors of the Soluble Epoxide Hydrolase In-Hae Kim, Yong-Kyu Park, Bruce D... .; Hammock, B. D. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal... inflammation by treatment with a soluble epoxide hydrolase ... |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||
| 100 | Life Sciences, Vol. 32, pp. 2693-2700 Pergamon Press Printed in the U.S.A. | ||
|
Summary: EPOXIDE HYDROLASES IN RHESUS MONKEY LIVER, AND IN NORMAL AND NEOPLASTIC HUMAN LIVER Sarjeet S. Gill... (Received in final form March 25, 1983) Summary The cytosolic epoxide hydrolase (EH-LC) was observed... in rhesus monkey liver cytosol, and in both normal and neoplastic human liver. Microsomal epoxide hydrolase |
|||
|
Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis |
|||
|
Collection: Biotechnology |
|||