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Sample search results for: a4 hydrolase inhibitors

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1 UC Davis Partnering opportunities: Arachidonic acid pathway
 

Summary:  Synthase LTA4 Hydrolase 9-HETE 11-HETE 8-HETE 12-HETE Lipoxin A4 12-LOX 15-HETE (15-HODE) 15-oxo-ETE 15-LOX... hydrolase inhibitors and FLAP inhibitors. We are able to monitor eisosanoid profiles in animal models... demonstrated that inhibitors ...

  

Source: Nguyen, Danh - Department of Public Health Sciences, University of California, Davis

 

Collection: Biology and Medicine ; Mathematics

 
2 INVITED REVIEW The Soluble Epoxide Hydrolase as a Pharmaceutical
 

Summary:  the carbonyl of the central pharmacophore of the urea as illustrated by the inhibitors shown in Figures 3A, 4... Words: soluble epoxide hydrolase, epoxide hydrolase, epoxide hydrolase inhibitor, inflammation... ; sEHI, soluble epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
3 pubs.acs.org/jmcr XXXX American Chemical Society J. Med. Chem. XXXX, XXX, 000000 A
 

Summary:  of the R-ketoheterocycle inhibitors 3-5 bound to a humanized variant of fatty acid amide hydrolase (FAAH... of action (Figure 1A).4,14 To date, two key classesofinhibitorshavebeenpursuedthatprovideopportunities... selectivity (vs other serine hydrolases),37,38,49 and signifi- cantly ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
4 Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo
 

Summary:  receptor targeted inhibitor sunitinib is a potent in- hibitor of the human soluble epoxide hydrolase... of sorafenib as a soluble epoxide hydrolase inhibitor indicate that the soluble epoxide hydrolase... -AUCB (C; B and C are potent soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
5 Epoxide hydrolases: their roles and interactions with lipid metabolism
 

Summary:  , leukotriene A4 hydrolase, the microsomal epoxide hydrolase, and the insect juvenile hor- mone epoxide... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2.4. Leukotriene A4 hydrolase... ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
6 Soluble Epoxide Hydrolase in Atherosclerosis Yi-Xin Jim Wang & Arzu Ulu & Le-Ning Zhang &
 

Summary:  via Gs [5], leading to membrane hyperpolarization, hence causing COX LOX P450 2C/2J sEH P450 4A/4F Fig... and related com- pounds; and 3) CYP450, form- ing epoxides (2C/2J) and 20-HETEs (4A/4F). Epoxyeico- satrienoic... F Fig. 2 Representative structures of soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
7 Chemistry & Biology Discovery and Characterization of a
 

Summary:  -baseline levels by 7 hr posttreatment (Figures 4A­4C). The different rates of recovery of both FAAH activity... (Figure 2A) and NAE levels (Figures 4A­4C) in mice treated with PF-3845 versus URB597 likely reflect... hydrolase inhibitors with remarkable selectivity. ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
8 Introduction The epoxyeicosatrienoic acids (EETs), products
 

Summary:  EH), mi- crosomal epoxide hydrolase (mEH), leukotriene A4 hydrolase, hepoxilin A3 hydrolase, and choles... of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl... , Sanborn JR and Hammock BD. ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
9 Structure-Activity Relationships of r-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase Christophe Hardouin,, Michael J. Kelso,, F. Anthony Romero,, Thomas J. Rayl,, Donmienne Leung,, Inkyu Hwang,,
 

Summary:  Structure-Activity Relationships of r-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase... (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting the C2 acyl... selective for FAAH over other mammalian serine hydrolases61 and a set of irrevers- ible ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
10 Potent and Selective r-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase
 

Summary:  ), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targeting the 5-position... selective for FAAH over other mammalian serine hydrolases62 and a set of irreversible inhibitors48... not significantly inhibit the common P450 metabolism enzymes ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
11 Soluble Epoxide Hydrolase Inhibitors and Heart Failure Jun-Yan Liu,3
 

Summary:  REVIEW Soluble Epoxide Hydrolase Inhibitors and Heart Failure Hong Qiu,1 Ning Li,1 Jun-Yan Liu,3... ; Epoxyeicosatrienoic acids (EETs); Heart failure; Soluble epoxide hydrolase inhibitors. Correspondence Nipavan... . Qiu et al. Soluble Epoxide Hydrolase Inhibitors in ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
12 [161 EPOXIDEHYDROLASES 303 consumption and related hormonal events, rather than photoperiod, are
 

Summary:  for at least four forms of epoxide hydrolase in verte- brate systems. One of these forms hydrates leukotriene A... ~p. Biol. 43, 1719(1984). [16] Epoxide Hydrolases in the Catabolism of Sterols and Isoprenoids By BRUCE D... . HAMMOCK, DAVID E. MOODY, and ALEX SEVANIAN Background Information Epoxide hydrolases ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
13 Chemistry & Biology A Comprehensive Profile of Brain Enzymes
 

Summary:  Profile of Mouse Brain 2-AG Hydrolases #12;residues by the NAM inhibitor) (Figure 5A; Figure S3). THL (20... of inhibitors on the 2-AG hydrolase activity of brain-membrane preparations. Con- sistent with previous studies... min) to block MAGL activity. (E) Effects of inhibitors on total ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
14 This article was originally published in a journal published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  serine hydrolase inhibitors, a custom-synthesised inhibitor, 10-(fluoro- ethoxyphosphinyl... "elbow" on the sharp turn between strand b-F and helix a-4, with this strained geometry typical... of the Active site of the Serine Esterase S-Formylglutathione Hydrolase Ian ...

  

Source: Davis, Ben G. - Department of Chemistry, University of Oxford

 

Collection: Chemistry

 
15 pubs.acs.org/jmc Published on Web 11/11/2010 r 2010 American Chemical Society 8376 J. Med. Chem. 2010, 53, 83768386
 

Summary:  including leukotriene A4 hydrolase, cho- lesterol epoxide hydrolase,2 hepoxilin hydrolase,3 microsomal... ,3-Disubstituted Urea as the Tertiary Pharmacophore Affording Potent Inhibitors of Soluble Epoxide Hydrolase... ortho 28a 3 CH3CO 990 25.2 ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
16 Annu. Rev. Pharmacol. Toxicol. 2005. 45:31133 doi: 10.1146/annurev.pharmtox.45.120403.095920
 

Summary:  on September 22, 2004 EPOXIDE HYDROLASES: Mechanisms, Inhibitor Designs, and Biological Roles Christophe... al. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation... of California, Davis, California 95616; email: bdhammock@ucdavis.edu Key Words ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
17 Biochemical Pharmacology, Vol.30, No. 15,pp.2111-2120,1981 Printedin Great Britain.
 

Summary:  hydrolase, also serve as good inhibitors of the mitochondrial epoxide hydrolase. DISCUSSION The results... .?952:81!152111-IO$02.0010 0 19RlPergamon PressLtd. EPOXIDE HYDROLASE ACTIVITY IN THE MITOCHONDRIAL... October 1980; accepted 16 January 1981) Abstract-Distribution of epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
18 CLAN CA C1B 372. Bleomycin hydrolase 1197 372. Bleomycin hydrolase
 

Summary:  is a weak inhibitor for the yeast and rat enzymes but has no effect on the human bleomycin hydrolase... CLAN CA ­ C1B 372. Bleomycin hydrolase 1197 372. Bleomycin hydrolase Databanks MEROPS name... : Bleomycin hydrolase (animal) MEROPS classification: clan CA, family C1B, peptidase ...

  

Source: Joshua-Tor, Leemor - W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory

 

Collection: Biology and Medicine

 
19 Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease
 

Summary:  epoxide hydrolase (sEH) and sEH inhibitors are considered treatment for chronic renal failure (CRF). We... . In contrast, 12-HETE and the Cyp450a4- product 20-HETE were unaffected in this scenario, excluding... , Zaharis CZ, Olearczyk JJ, Pollock DM, et al. (2005) An orally active epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
20 doi:10.1152/ajpendo.00710.2010 300:E691-E698, 2011. First published 25 January 2011;Am J Physiol Endocrinol Metab
 

Summary:  , lipoxygen- ase, and cyclooxygenase pathways. hypertension; soluble epoxide hydrolase inhibitors; perinatal... .01 vs. 2 wk). 8-hydroxyeicosatetraenoic acid (8- HETE) also increased with age. Lipoxin A4 (LXA4), throm... . An epoxide hydrolase inhibitor, ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology


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21 DIFFERENTIAL SUBSTRATE SELECTIVITY OF MURINE HEPATIC CYTOSOLIC AND MICROSOMAL EPOXIDE
 

Summary:  to be reasonable inhibitors of the cytosolic epoxide hydrolase, indicating that the structural requirements... epoxide hydrolase. Fat instance. the best inhibitor, tmns-stilbene oxide. has a K, of 1 x lo-`M compared... . Trichloropropene oxide (16) has been widely used as an inhibitor of ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
22 Exploration of a fundamental substituent effect of a-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase
 

Summary:  and selective inhibitors of fatty acid amide hydrolase Jessica K. DeMartino, Joie Garfunkle, Dustin G... -ketooxazoles were examined as inhibitors of the serine hydrolase fatty acid amide hydrolase in efforts that further... Li Scheme 1. H Br Cl I CH3 SCH3 CHO COCH3 CF3CO CO2CH3 48 3.0 4.0 ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
23 General introduction into Nudix hydrolase proteins General introduction into Nudix hydrolase proteins
 

Summary:  11 Chapter 1 General introduction into Nudix hydrolase proteins #12;12 #12;General introduction... into Nudix hydrolase proteins 13 Different chemical and physical forces constantly threaten the integrity... ). The MutT or Nudix hydrolase protein family In an amino acid comparison of the E. coli MutT sequence

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
24 Profiling Serine Hydrolase Activities in Complex Proteomes Dana Kidd, Yongsheng Liu, and Benjamin F. Cravatt*
 

Summary:  hydrolase inhibitors directly in complex proteomes. Finally, a general method for the avidin-based affinity... selectivity of reversible serine hydrolase inhibitors directly in complex proteomes, and (iii) isolate... Vity of ReVersible Serine Hydrolase Inhibitors in ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
25 FEBS Letters 338 (1994) 251-256 Sequence similarity of mammalian epoxide hydrolases to the bacterial
 

Summary:  acetyltransferdse hpase magnesmm chelatase luciferase bromoperoxldase leukotnene A4 hydrolase Rattus norvegicus... of mammalian epoxide hydrolases to the bacterial haloalkane dehalogenase and other related proteins Implication... and soluble epoxlde hydrolase superficially mdlcates that ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
26 Human soluble epoxide hydrolase: Structural basis of inhibition by
 

Summary:  epoxide hydrolase. (B) General binding mode of a dialkylurea inhibitor, which mimics the transition state... . Data from Kim et al. 2004. Table 1. Epoxide hydrolase inhibitors www.proteinscience.org 59 Human... epoxide hydrolase­inhibitor complexes #12;inhibitor ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
27 MOLECULAR, CELLULAR, AND DEVELOPMENTAL BIOLOGY The Cloning and Characterization of a Soluble Epoxide Hydrolase in Chicken
 

Summary:  EPOXIDE HYDROLASE IN CHICKEN 279 thelial cells using an sEH inhibitor (Fang et al., 2001). In vivo... ;CHARACTERIZATION OF A SOLUBLE EPOXIDE HYDROLASE IN CHICKEN 285 Figure 4. IC50 values for the urea-based inhibitors... . Hammock. 2005. Epoxide hydrolases: Mechanisms, ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
28 Introduction Amidohydrolases
 

Summary:  -peptide amidohydrolases is formed by the serine hydrolases; it makes use of a nucleophilic serine that attacks... the scissile amide bond. A classic catalytic scaffold for serine-hydrolases consists of a catalytic triad... in chymotrypsin by Blow et al. (1969), and similar catalytic triads were found later in other peptide ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
29 Inhibitor SourceBookTM Your #1 Resource for Quality Inhibitors
 

Summary:  Inhibitor SourceBookTM Your #1 Resource for Quality Inhibitors Includes inhibitors... /Dephosphorylation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3 Akt (Protein Kinase B) Inhibitors... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
30 Inactivation of epoxide hydrolase by vicinal diols
 

Summary:  . Vicinal diols are competitive inhibitors of this epoxide hydrolase (Baldascini et al., 2001). During... ;Chapter 4 since at high concentrations it is a competitive inhibitor of epoxide hydrolase. Conversion... , a strong inhibitor of epoxide hydrolase, was tested by ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
31 Comp. Biochem.Physiol.Vol. 87B,No. 1, pp. 95-102, 1987 0305-0491/87 $3.00+ 0.00 Printed in Great Britain 1987PergamonJournalsLtd
 

Summary:  -5881. McGee J. and Fitzpatrick F. (1985) Enzymatichydration of lenkotrine A4. J. biol. Chem. 260, 12832... Britain © 1987PergamonJournalsLtd AFFINITY PURIFICATION OF CYTOSOLIC EPOXIDE HYDROLASE FROM HUMAN, RHESUS... 1986) Abstract--1. An affinity purification system based on elution of cytosolic epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
32 Inhibition of Microsomal Epoxide Hydrolases by Ureas, Amides, and Amines
 

Summary:  if it is used as a mEH inhibitor. We recently developed new inhibitors for the soluble epoxide hydrolase (s... ) 1,2-Epoxycyclo- alkanes: substrates and inhibitors of microsomal and cytosolic epoxide hydrolases... of potent inhibitors of human microsomal epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
33 Summary and concluding remarks In this chapter the main findings of the work described in this thesis,
 

Summary:  of diols on epoxide hydrolase activity Vicinal diols are competitive inhibitors of epoxide hydrolase. We... an epoxide hydrolase originally isolated from the organism Agrobacterium radiobacter AD1 (van den Wijngaard... . Inactivation of epoxide hydrolase was found to be caused by direct ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
34 Integrative Physiology Redox Regulation of Soluble Epoxide Hydrolase by
 

Summary:  is a sEH inhibitor using an established epoxide hydrolase spectrophotometric activity assay. These s... distinct pharmacological inhibitors of this hydrolase (AUDA or t-AUCB) themselves indepen- dently induced... These past inconsistencies along with the fact that hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
35 Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble
 

Summary:  levels, the hydrolase domain lowered cholesterol levels. Hydrolase inhibitor treatment ins... hydrolase inhibitor- treated male and female sEH-WT mice as compared with sEH-KO. n four animals... mechanisms. For example, the effect of the hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
36 Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling
 

Summary:  Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein... -based proteomics Biosynthesis Endocannabinoid Inhibitor Lipase a b s t r a c t The endocannabinoid 2... on pharmacological studies using inhibitors of the 2-AG biosynthetic enzymes diacyglycerol lipase a and b (DAGL

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
37 Fatty acid amide hydrolase: an emerging therapeutic target in the endocannabinoid system
 

Summary:  -tissue proteomes, FAAH inhibitors were tested for their ability to slow the rate of labeling of serine hydrolases... : Bisarylimidazolyl fatty acid amide hydrolase inhibitors. Patent application W0 02/087569, 2002. This patent... Fatty acid amide hydrolase: an emerging therapeutic target ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
38 Protease Inhibitors -Application Table Protease Inhibitors -Application Table
 

Summary:  ) and leucine aminopeptidase. Inhibitor of leukotriene A4 hydrolase and of enkephalin degradation in cell... Protease Inhibitors - Application Table Protease Inhibitors - Application Table The following table... gives an overview on the use and application of ...

  

Source: Lebendiker, Mario - Wolfson Centre for Applied Structural Biology, Hebrew University of Jerusalem

 

Collection: Biotechnology ; Biology and Medicine

 
39 Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders
 

Summary:  the name fatty acid amide hydrolase (FAAH) (5). Another prominent substrate-derived inhibitor is MAFP (6... irreversible inhibitor of FAAH and several other serine hydrolases (52,63,64). As described in section 7... , activity- based probes to profile the proteomic selectivity of FAAH ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
40 Current Pharmaceutical Biotechnology, 2009, 10, 589-599 589 1389-2010/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  epoxide hydrolase, tryptophan fluorescence quenching, enzyme inhibitors, inhibitor detection. INTRODUCTION... hydrolases: mechanisms, inhibitor designs, and biological roles. Ann. Rev. Pharmacol. Toxicol., 45, 311... - lurea inhibitors to epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology


Page:   1  2  3  4  5 
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41 Many of the enzymes, receptors and eicosanoid metabo-lites of the arachidonate cascade (FIG. 1) are key thera-
 

Summary:  of hypertension. Figure 2 | soluble epoxide hydrolase inhibitor (seHi) structures and binding to the enzymatic... | Antihypertensive and end-organ protective actions of soluble epoxide hydrolase inhibitors (seHis). a | The increase... -inflammatory drugs (NSAIDs), including inhibitors of ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
42 Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity
 

Summary:  Novel Mechanistic Class of Fatty Acid Amide Hydrolase Inhibitors with Remarkable Selectivity... of serine hydrolase inhibitors including fluorophosphonates (21), trifluoromethyl ketones (22), R... a global view of the proteome-wide selectivity of serine hydrolase ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
43 Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence for an Unprecedented
 

Summary:  Reversible Inhibitors of Fatty Acid Amide Hydrolase That Promote Analgesia: Evidence... for evaluating the potency and selectivity of serine hydrolase inhibitors in whole proteomes (Leung et al., 2003... )] determined by activity-based protein profiling for serine hydrolases sensitive to ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
44 Structural Characterization of Enterobactin Hydrolase IroE, N. A. Larsen, H. Lin,, R. Wei, M. A. Fischbach,,| and C. T. Walsh*,
 

Summary:  fluorophosphonate (DFP, a potent serine hydrolase inhibitor) were determined at 2.3 and 1.4 Å resolution... the ferric ion into the cytoplasm (Figure 2A) (4). Despite the high affinity of Ent for iron, the efficiency... Articles Structural Characterization of Enterobactin Hydrolase IroE, ...

  

Source: Walsh, Christopher T.- Department of Biological Chemistry and Molecular Pharmacology, Harvard University

 

Collection: Biology and Medicine

 
45 Identification of the catalytic residues of -amino acid ester hydrolase from Acetobacter turbidans by labeling and site-
 

Summary:  aminopeptidase. The serine hydrolase inhibitor p-nitrophenyl-p' -guanidino- benzoate appeared to be an active... of a histidine for the catalytic activity of AEH (Ryu and Ryu, 1988). However, common serine hydrolase inhibitors... with the serine hydrolase inhibitor ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
46 Prostaglandins & other Lipid Mediators 82 (2007) 4249 Soluble epoxide hydrolase inhibition reveals novel biological
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 45 Abbreviations: EET, epoxyeicosatrienoic acid; sEH, soluble epoxide hydrolase; sEHI, sEH inhibitors... 1995;270:7968­74. [18] Morisseau C, Hammock BD. Epoxide hydrolases: mechanisms, inhibitor ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
47 pubs.acs.org/jmcPublished on Web 09/02/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 70677075 7067
 

Summary:  relationships as inhibitors of the human and murine soluble epoxide hydrolase (sEH). Oral administration of 13 1... by soluble epoxide hydrolase inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 18733­18738. (9) Morisseau... , C.; Hammock, B. D. Epoxide hydrolases: mechanisms, ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
48 Structure-guided inhibitor design for human FAAH by interspecies active site conversion
 

Summary:  hydrolase inhibitors [e.g., trifluoromethyl ketones (23, 24), flu- orophosphonates (25), -ketoheterocycles... to other lipid hydrolases. More recently, FAAH inhibitors with greatly improved selectivity have been... to determine the crystal structure of FAAH in complex with the general serine ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
49 The Putative Endocannabinoid Transport Blocker LY2183240 Is a Potent Inhibitor of FAAH and Several Other Brain Serine
 

Summary:  2183240 Is a Potent, Covalent Inhibitor of FAAH and Several Other Brain Serine Hydrolases. In the original... of heterocyclic ureas as inhibitors of serine hydrolases, including peptidases31 and hormone-sensitive li- pase.32... ) screen, the selectivity of an inhibitor for members of the ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
50 Chemistry & Biology Characterization of Monoacylglycerol Lipase
 

Summary:  by Irreversible Active-Site Carbamoylation Carbamate inhibitors typically inactivate serine hydrolases... Da, JZL184-sensitive band by gel-based ABPP in every tissue proteome analyzed (Figures 4A­4I). In brain... .05) of AEA in any of the tissues in this analysis (Figures ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
51 Discovery of a Potent, Selective, and Efficacious Class of Reversible r-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Effective as
 

Summary:  (() are provided in Supporting Informa- tion. Inhibitors of Fatty Acid Amide Hydrolase Journal of Medicinal... the serine hydrolase superfamily applicable to defining the selectivity of FAAH inhibitors was developed.42... profiling of the inhibitors against all proteome serine ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
52 BIOCHEMISTRY Analytical Biochemistry 355 (2006) 7180
 

Summary:  epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt... epoxide hydrolase inhibitor, Proc. Natl. Acad. Sci. USA 102 (2005) 2186­2191. [11] X. Zhao, T. Yamamoto, J... , An epoxide hydrolase inhibitor, 12-(3-adamantan-1- ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
53 Published: October 19, 2010 r 2010 American Chemical Society 2816 dx.doi.org/10.1021/jf102559q |J. Agric. Food Chem. 2011, 59, 28162824
 

Summary:  hydrolase inhibitors joined samples of EETs being delivered to laboratories around the world. An early... . Epoxide hydrolases: mechan- isms, inhibitor designs, and biological roles. Annu. Rev. Pharmacol. Toxicol... . R.; Hammock, B. D. Potent urea and carbamate inhibitors of soluble ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
54 Original article Pharmacophore-based virtual screening and Bayesian model for the identification
 

Summary:  of potential human leukotriene A4 hydrolase inhibitors Sundarapandian Thangapandian, Shalini John, Sugunadevi... screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors... ...

  

Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University

 

Collection: Biotechnology ; Biology and Medicine

 
55 Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and s-adenosyl methionine provide neuroprotection against multiple consequences of
 

Summary:  , including the S-adenosyl homocysteine hydrolase inhibitor, 3-deaza adenosine, the methyl donor S

  

Source: Graves, Michael V. - Department of Biological Sciences, University of Massachusetts at Lowell

 

Collection: Biology and Medicine

 
56 Diversity of serine hydrolase activities of unchallenged and Botrytis-infected Arabidopsis thaliana
 

Summary:  moiety in the broad-range serine hydrolase inhibitor DFP (diisopropyl fluorophosphonate). When used... plants. FP profiling can also be used to select for specific inhibitors of serine hydrolases. Specific... of serine hydrolases with reactive phosphonate inhibitors. ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
57 Development of Metabolically Stable Inhibitors of Mammalian Microsomal Epoxide Hydrolase
 

Summary:  Development of Metabolically Stable Inhibitors of Mammalian Microsomal Epoxide Hydrolase Christophe... ) KI of 430 ( 70, 72 ( 5, and 118 Inhibitors of Mammalian Microsomal Epoxide Hydrolase Chem. Res... determination of soluble epoxide hydrolase inhibitors in rat ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
58 Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase
 

Summary:  and a larger C-terminal which processes classical a/b-hydrolase activity.12,13 sEH inhibitors act through inhi... with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci USA 2005;102:2186­2191. 12. Newman JW, Morisseau C... , Hammock BD. Orally bioavailable potent soluble epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
59 Biochemical Evidence for the Involvement of Tyrosine in Epoxide Activation during the Catalytic Cycle of Epoxide Hydrolase*
 

Summary:  , wild-type (2.5 g); lane 2, Y381F (1.3 g); lane 3, Y465F (2.5 g); lane 4, Y465A (4.5 g); lane 5, Y381F... Cycle of Epoxide Hydrolase* Received for publication, February 22, 2000, and in revised form, May 3... , Pennsylvania 19104-6323 Epoxide hydrolases (EH) catalyze the hydrolysis of epoxides and arene ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
60 Polymorphisms in Human Soluble Epoxide Hydrolase BEATA D. PRZYBYLA-ZAWISLAK, PUNIT K. SRIVASTAVA, JOHANA V AZQUEZ-MATIAS, HARVEY W. MOHRENWEISER,
 

Summary:  A4 hydrolase, cholesterol EH, and microsomal EH), which differ in molec- ular weight, subcellular... , Hammock BD, and Christian- son DW (2000) Binding of alkylurea inhibitors to epoxide hydrolase implicates... Polymorphisms in Human Soluble Epoxide Hydrolase BEATA D. ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology


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61 Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis,
 

Summary:  inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation, J. Biol. Chem. 275... and carbamate inhibitors of soluble epoxide hydrolases, Proc. Natl. Acad. Sci. U.S.A. 96, 8849-8854. 34. Mc... ) Structural refinement of inhibitors of urea-based soluble ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
62 Chemical Strategies for Functional Proteomics* Gregory C. Adam, Erik J. Sorensen, and Benjamin F. Cravatt
 

Summary:  - ine hydrolases sensitive to trifluoromethyl ketone inhibitors of fatty acid amide hydrolase... of a mechanism-based reactive group (a 4-fluoromethyl-1-phosphophenyl substituent (50)), a diethyl- ene glycol... that target, for example, serine hydrolases (29, 30) and ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
63 A novel meta-cleavage product hydrolase from Flavobacterium sp. Syed Khajamohiddin a
 

Summary:  A novel meta-cleavage product hydrolase from Flavobacterium sp. ATCC27551 Syed Khajamohiddin... open-read- ing frame, orf243. This was predicted to encode an a/b hydrolase distantly related... to the meta-fission product (MFP) hydrolases such as XylF, PhnD, and CumD. By homology modeling Orf243 has

  

Source: Merrick, Mike - Department of Molecular Microbiology, John Innes Centre

 

Collection: Biology and Medicine

 
64 Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
 

Summary:  serine hydrolase inhibitors that block MAGL (along with several other enzymes, including FAAH... -based proteomic methods to broadly evaluate and optimize the selectivity of inhibitors across the serine hydrolase... 184 The pursuit of selective inhibitors for serine ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
65 Enantioselective Biocatalytic Conversions of Epoxides
 

Summary:  hydrolase (mEH), soluble epoxide hydrolase (sEH), cholesterol epoxide hydrolase, leukotriene A4 epoxide... . Ik wil Rick, Jaap en Bert (epoxide hydrolase), Johan, Lixia en Ghannia (haloalcohol dehalogenase... hydrolase discussions. Yvonne Genzel ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
66 Crystal structure of carboxylesterase from Pseudomonas fluorescens, an a/b hydrolase with broad substrate specificity
 

Summary:  and inhibitor- bound structures. Conclusions: Carboxylesterase from P. fluorescens has the / hydrolase fold... hydrolase inhibitors such as phenylmethylsul- fonyl fluoride (PMSF). This is consistent with the pres- ence... with the inhibitor PMSF. Each subunit of the enzyme has the / ...

  

Source: Suh, Se Won - School of Chemistry, Seoul National University

 

Collection: Chemistry ; Biotechnology

 
67 DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism
 

Summary:  -CdR treatment in a dose-dependent manner (Fig. 2A); 4 M 5-Aza-CdR switched most methylated sites to unmethylated... competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase... DNA methylation of the promoter of soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
68 Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid
 

Summary:  . hydrolase inhibitor metabolism N-arachidonoyl ethanolamine (anandamide or AEA) (1) and 2... agonists and endocannabinoid hydrolase inhibitors are potentially exciting from a therapeutic perspective... -selective inhibitor JZL184, and dual FAAH-MAGL inhibitors. (B) ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
69 Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate Activation*
 

Summary:  Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate... The structures of two alkylurea inhibitors complexed with murine soluble epoxide hydrolase have been deter- mined... 381 is conserved among the soluble epoxide hydrolases. In one ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
70 Lipid Sulfates and Sulfonates Are Allosteric Competitive Inhibitors of the N-Terminal Phosphatase Activity of the Mammalian Soluble Epoxide Hydrolase
 

Summary:  . Morisseau, C., and Hammock, B. D. (2005) Epoxide hydrolases: mechanisms, inhibitor designs and biological... ) Potent urea and carbamate inhibitors of soluble epoxide hydrolases, Proc. Natl. Acad. Sci. U.S.A. 96... Lipid Sulfates and Sulfonates Are Allosteric Competitive Inhibitors of the ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
71 Structural renement of inhibitors of urea-based soluble epoxide hydrolases
 

Summary:  Structural re®nement of inhibitors of urea-based soluble epoxide hydrolases Christophe Morisseaua... . Keywords: Epoxide hydrolase; Blood pressure; Immune response; Urea inhibitors; Structure... JR, Hammock BD. Potent urea and carbamate inhibitors of soluble epoxide ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
72 Interfacial inactivation of epoxide hydrolase in a two-liquid-phase system
 

Summary:  concentrations it is a competitive inhibitor of epoxide hydrolase. Conversion curves were either numerically... Chapter 3 Interfacial inactivation of epoxide hydrolase in a two-liquid-phase system Abstract... Enantioselective epoxide hydrolases are useful biocatalysts for the preparation of enantiopure ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
73 Activity-based protein profiling: The serine hydrolases Yongsheng Liu, Matthew P. Patricelli, and Benjamin F. Cravatt*
 

Summary:  probe for serine hydrolases. Powers and colleagues had generated isocoumarin inhibitors coupled... to biotin as serine hydrolase inhibitors (19, 20). Al- though these isocoumarins reacted with a greater... hydrolase (FAAH) (24). As expected, FP-biotin behaved as a potent irreversible ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
74 doi:10.1152/ajprenal.00098.2009 297:740-748, 2009. First published Jun 24, 2009;Am J Physiol Renal Physiol
 

Summary:  , and the sEH inhibitors inhibit the epoxide hydrolase activity of the C-terminal domain without affecting... . To determine that renal protection resides within the hydrolase domain of the Ephx2 gene, sEH inhibitor studies... / DOCA-salt mice were treated with tAUCB, a sEH inhibitor that ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
75 Soluble Epoxide Hydrolase Inhibition Lowers Arterial Blood Pressure in Angiotensin II Hypertension
 

Summary:  epoxide hydrolase regulation in Ang II hypertension and the ability of epoxide hydrolase inhibitors... in the same manner. Following the measurement of blood pressure, the epoxide hydrolase inhibitors (3 mg/d IP... injection of epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
76 The -amylase family: Transglycosylation and Hydrolysis Reaction Specificity
 

Summary:  /hydrolysis specificity of -amylase family enzymes, as this distance is larger in a maltosyltransferase (a 4--gluca... distinct reaction specificities. The maltosyltransferase (a 4--glucanotransferase) from Thermotoga maritima... by a large collection of enzymes involved in carbohydrate processing. Glycoside ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
77 Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)
 

Summary:  Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma... Available online 6 February 2010 Keywords: Hydrolase Inhibitor Screening Proteomics a b s t r a c t We... hydrolases,8,9 of our most potent inhibitor 18 to potentially further ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
78 S P O T L I G H T O N H E A R T F A I L U R E T R A N S L A T I O N A L R E S E A R C H George W. Booz, PhD
 

Summary:  by application of soluble epoxide hydrolase (sEH) inhibitors in a murine MI model. 20-Hydroxyeicosatetraenoic... therapeutic aspects of soluble epoxide hydrolase inhibitors. Cardiovasc Drug Rev. 2006;24:169­188. 34 Larsen... , Davis BB, Tsai HJ, et al. Soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
79 0 1993 hy The American Society for Biochemistry and Molecular Biology, Inc. THEJOURNALOF BIOLOGICALCHEMISTRY Vol. 268, No. 23, Issue of August 15, pp. 17628-17633, 1993
 

Summary:  - ceeds by a different mechanism than that of the sEH and is very specific for leukotrieneA4... and Expressionof Murine Liver Soluble Epoxide Hydrolase* (Received for publication, March 2, 1993) David F. Grant... prepared and used to isolate the coding sequence for soluble epoxide hydrolase. A 1668-base pair ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
80 RESEARCH PAPER Pharmacokinetic optimization of four soluble
 

Summary:  RESEARCH PAPER Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use... of California, Davis, CA, USA Background and purpose: Early soluble epoxide hydrolase inhibitors (s... , pharmacokinetic; sEH, soluble epoxide hydrolase; sEHI, sEH ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology


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81 RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia
 

Summary:  RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia David J... -associated serine hydrolase that displays elevated activity in pancreatic carcinomas. Whereas RBBP9 is expressed... unknown role for a serine hydrolase in cancer biology. Conversely, loss of endogenous RBBP9 or expression

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
82 Biochemical Characterization -Amino Acid Ester Hydrolases
 

Summary:  Biochemical Characterization of -Amino Acid Ester Hydrolases #12;The cover picture... is a photomicrograph of amoxicillin crystals, one of the antibiotics the -amino acid ester hydrolases can make... ;Rijksuniversiteit Groningen Biochemical Characterization of -Amino Acid Ester Hydrolases Proefschrift ter

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
83 doi:10.1152/ajpheart.00543.2009 298:795-806, 2010. First published Dec 24, 2009;Am J Physiol Heart Circ Physiol
 

Summary:  , Hammock BD, Weiss RH. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell... , Hammock BD, Imig JD. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ure- ido)dodecanoic acid (AUDA... urea-derived soluble epoxide hydrolase inhibitors. J ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
84 EVOLUTION OF ENANTIOSELECTIVITY SELECTION OF IMPROVED HYDROLASE VARIANTS
 

Summary:  EVOLUTION OF ENANTIOSELECTIVITY SELECTION OF IMPROVED HYDROLASE VARIANTS #12;#12;RIJKSUNIVERSITEIT... GRONINGEN Evolution of Enantioselectivity Selection of Improved Hydrolase Variants Proefschrift ter... : Directed evolution of Bacillus subtilis lipase A using enantiomeric phosphonate inhibitors: crystal

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
85 Vascular localization of soluble epoxide hydrolase in the human kidney Zhigang Yu,1
 

Summary:  Vascular localization of soluble epoxide hydrolase in the human kidney Zhigang Yu,1 Benjamin B... L. Kroetz, and Robert H. Weiss. Vascular localization of soluble epoxide hydrolase in the human... proliferation, and inflammation. Epoxyeicosatrienoic acids are converted by soluble epoxide hydrolase

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
86 Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies
 

Summary:  and carbamate inhibitors of soluble epoxide hydrolases, Proc. Natl. Acad. Sci. USA 96 (1999) 8849­8854. [15] C... of inhibitors of urea-based soluble epoxide hydrolases, Biochem. Pharmacol. 63 (2002) 1599­1608. [16] Y... Fluorescent substrates for soluble epoxide hydrolase and ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
87 A putative novel alpha/beta hydrolase ORFan family in Bacillus Naomi Siewa,b
 

Summary:  in the templatesÕ sequences that have no matching sequence in Banthracis were omitted: the beginning of a4, the end... . Additional elements are marked with an apostrophe (a b strand after b3 and an a helix after a4). The multiple... A putative novel alpha/beta hydrolase ORFan family in ...

  

Source: Fischer, Daniel - Center of Excellence in Bioinformatics and Life Sciences & Department of Computer Science and Engineering, State University of New York at Buffalo

 

Collection: Computer Technologies and Information Sciences ; Biotechnology ; Biology and Medicine

 
88 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  , Development of metabolically stable inhibitors of mammalian microsomal epoxide hydrolase, Chem. Res. Toxicol... 's personal copy Development of fluorescent substrates for microsomal epoxide hydrolase and application... epoxide hydrolase Fluorescent substrate a-Cyanocarbonate Xenobiotic metabolism a b s t r a ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
89 Aminopeptidase Fingerprints, an Integrated Approach for Identification of Good Substrates and Optimal Inhibitors*S
 

Summary:  of leukotriene A4 hydrolase/aminopeptidase, which belongs to the same family as APN (32). Leukotriene A4... and Optimal Inhibitors*S Received for publication,August 27, 2009, and in revised form, November 10, 2009... inhibitors, and more ...

  

Source: Bogyo, Matthew - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
90 ORIGINAL ARTICLE Inhibition of Soluble Epoxide Hydrolase by trans-4-
 

Summary:  by soluble epoxide hydrolase (sEH). To study the effects of pharmacological inhibitor of sEH (sEHi), C57BL6... ;295: H2128­H2134. 16. Morisseau C, Hammock BD. Epoxide hydrolases: mechanisms, inhibitor designs... . Li J, Carroll MA, Chander PN, et al. Soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
91 Molecular Docking and Pharmacophore Filtering in the Discovery of Dual-Inhibitors for Human Leukotriene A4 Hydrolase and Leukotriene C4 Synthase
 

Summary:  A4 hydrolase inhibitor in comparison with the 5-lipoxy- genase inhibitor Zileuton. J. Pharmacol. Exp... Leukotriene A4 Hydrolase and Leukotriene C4 Synthase Sundarapandian Thangapandian, Shalini John, Sugunadevi... structure ...

  

Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University

 

Collection: Biotechnology ; Biology and Medicine

 
92 Attenuation of Vascular Smooth Muscle Cell Proliferation by 1-Cyclohexyl-3-dodecyl Urea Is Independent of Soluble
 

Summary:  of their regulatory enzyme, soluble epoxide hydrolase (sEH), can mimic these effects. For this reason, sEH inhibitors... epoxide hydrolase inhibitor. Proc Natl Acad Sci USA 102:2186­ 2191. Sun J, Sui X, Bradbury JA, Zeldin DC... Is Independent of Soluble Epoxide Hydrolase Inhibition ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
93 The Crystal Structure of the Hydrolase Domain of 10-Formyltetrahydrofolate Dehydrogenase
 

Summary:  The Crystal Structure of the Hydrolase Domain of 10-Formyltetrahydrofolate Dehydrogenase MECHANISM... biosynthesis, to tetrahydrofolate. The protein com- prises two functional domains: a hydrolase domain... - zyme, we have determined the crystal structure of the hydrolase domain of FDH from rat, solved to 2.3-Å

  

Source: Davies, Christopher - Department of Biochemistry and Molecular Biology, Medical University of South Carolina

 

Collection: Biology and Medicine

 
94 Insect Biochemistry and Molecular Biology 32 (2002) 17411756 www.elsevier.com/locate/ibmb
 

Summary:  and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm (Manduca sexta... 2002 Abstract A new class of inhibitors of juvenile hormone epoxide hydrolase (JHEH) of Manduca sexta... epoxide hydrolases. The best inhibitors against ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
95 Synthesis of New Carboxylesterase Inhibitors and Evaluation of Potency and Water Solubility
 

Summary:  aluminum hydride (1.85 mmol, 3.7 mL) was added to a stirred solution of 2a (4.0 mmol, 1.02 g) in diethyl... .46 4a 6.63 1b 1.17 4b 4.34 2a 4.51 5a 2.91 2b 2.23 5b 0.62 3a 5.57 JH IIIb 4.35 3b 3.28 a Clog... Articles Synthesis of New Carboxylesterase Inhibitors and Evaluation of Potency and ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
96 QSAR and Classification of Murine and Human Soluble Epoxide Hydrolase Inhibition by Urea-Like Compounds
 

Summary:  and Predicted log IC50 (µM) Values and Predicted Class Labels for Soluble Epoxide Hydrolase Inhibitors no. seta... murine cls. calcde 1 3,4 Aldrich N/A x - N/A - 2 3,4 Aldrich N/A x - N/A - 3 3,4 Aldrich N/A x - N/A - 4... quantitative model (human soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
97 Stable and enantioselective cross-linked epoxide hydrolase crystals
 

Summary:  . It is possible that co-cross-linking with a competitive 112 #12;Cross-linked epoxide hydrolase crystals inhibitor... Chapter 5 Stable and enantioselective cross-linked epoxide hydrolase crystals Abstract... In this chapter the formation and application of cross-linked crystals of epoxide hydrolase to the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
98 Chemical Biology ()-FR182877 Is a Potent and Selective Inhibitor
 

Summary:  for serine hydrolases[29] and can been used to evaluate the potency and selectivity of inhibitors that target... of lactone natural products serving as inhibitors of serine hydrolases are known. For example, lipstatin... and selective inhibitors of many members of the serine ...

  

Source: Cravatt, Benjamin - Department of Cell Biology, Scripps Research Institute

 

Collection: Biology and Medicine

 
99 Published: February 21, 2011 r 2011 American Chemical Society 1752 dx.doi.org/10.1021/jm101431v |J. Med. Chem. 2011, 54, 17521761
 

Summary:  of Cycloalkylamide Derivatives as Inhibitors of the Soluble Epoxide Hydrolase In-Hae Kim, Yong-Kyu Park, Bruce D... .; Hammock, B. D. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal... inflammation by treatment with a soluble epoxide hydrolase ...

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology

 
100 Life Sciences, Vol. 32, pp. 2693-2700 Pergamon Press Printed in the U.S.A.
 

Summary:  EPOXIDE HYDROLASES IN RHESUS MONKEY LIVER, AND IN NORMAL AND NEOPLASTIC HUMAN LIVER Sarjeet S. Gill... (Received in final form March 25, 1983) Summary The cytosolic epoxide hydrolase (EH-LC) was observed... in rhesus monkey liver cytosol, and in both normal and neoplastic human liver. Microsomal epoxide hydrolase

  

Source: Hammock, Bruce D. - Department of Entomology, University of California, Davis

 

Collection: Biotechnology


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