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Sample search results for: abasic sites induced

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1 Oligonucleotides with Bistranded Abasic Sites Interfere with Substrate Binding and Catalysis by Human Apurinic/Apyrimidinic Endonuclease
 

Summary:  induced by the presence of a second abasic site might provide insight into how AP endo recognizes... Oligonucleotides with Bistranded Abasic Sites Interfere with Substrate Binding and Catalysis... DNA repair. The enzyme, which repairs abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
2 Molecular Cell, Vol. 13, 751762, March 12, 2004, Copyright 2004 by Cell Press Snapshots of Replication through
 

Summary:  B homolog) from two related Sulfolobus strains are able to extend primer strands past abasic sites... with the abasic site looped out and finger and little finger domains provides an entry channelthe incoming... when the abasic site remains extrahelical. incoming ...

  

Source: Ling, Hong - Department of Biochemistry, University of Alberta

 

Collection: Biology and Medicine

 
3 Submitted to J. Biol. Chem. Draft of July 13, 2001
 

Summary:  /apyrimidinic endonuclease; ASR, abasic site repair, bp, base pair; ds, double-stranded; ESR, electron spin resonance; HDP... structure, ss, single- stranded #12;3 Introduction Abasic site repair (ASR) refers to one of several repair... pathways that generate and repair an abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
4 Abasic Site Repair in Higher Eukaryotes Phyllis R. Strauss and Noreen E. O'Regan
 

Summary:  3 Abasic Site Repair in Higher Eukaryotes Phyllis R. Strauss and Noreen E. O'Regan 1. INTRODUCTION... of abasic sites generated per mammalian cell per day run as high as 106/cell/d (88). Abasic sites... the large number of abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
5 Clustered DNA damages induced in isolated DNA and in human cells by low doses of ionizing radiation
 

Summary:  , with a minority of radiation- induced abasic sites. The Nth protein cleaves regular abasic sites well, but seems... oxidized py- rimidine sites and ionizing radiation-induced regular abasic sites. ...

  

Source: Brookhaven National Laboratory, Environmental Chemistry Division, Department of Applied Science

 

Collection: Environmental Sciences and Ecology

 
6 Charge Transport in DNA Oligonucleotides with Various Base-Pairing Patterns Irena Kratochvilova,*,
 

Summary:  A, G, C, and T) and dSpacer CE Phosphoramidite (for abasic sites) were purchased from Glen Research... duplex interior at the abasic sites can partially compen- sate for the loss of overlap between the base... . Structurally and thermally much less stable abasic duplexes have still lower ...

  

Source: Kužel, Petr - Institute of Physics, Academy of Sciences of the Czech Republic

 

Collection: Physics

 
7 Notes & Tips A nonisotopic assay for unambiguous assignment of DNA
 

Summary:  but leave be- hind an abasic or apurinic/apyrimidinic (AP)1 site in DNA [4]. Thus, for the analysis... strand scission adjacent to the abasic site. The lack of current DNA glycosylase assays to concur- rently... denaturing PAGE, taking into account the inherent lability of abasic ...

  

Source: Boston University, Center for Advanced Biotechnology

 

Collection: Biotechnology

 
8 DNA Repair 3 (2004) 14471455 Novel role of tyrosine in catalysis by human AP endonuclease 1
 

Summary:  ) recognizes abasic sites in ds DNA and makes a single nick in the backbone 5 to the abasic site... . We show that Tyr128 and Tyr269 , which interact upstream and downstream of the abasic site... , respectively, are involved in recognition and binding of ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
9 Effect of Protein Binding on Ultrafast DNA Dynamics: Characterization of a DNA:APE1 Complex
 

Summary:  or chemically induced hydrolysis of the N-glycosidic bond (14,26,27). APE1 begins the repair of an abasic site... oligonucleotide at the abasic site opposite the coumarin with only a fourfold reduction in rate. In addition... in binding constant relative to a native oligonucleotide ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
10 Domain Mapping of Human Apurinic/Apyrimidinic Endonuclease STRUCTURAL AND FUNCTIONAL EVIDENCE FOR A DISORDERED AMINO TERMINUS AND A TIGHT
 

Summary:  induce a bend in the DNA, enabling the abasic site to become accessible to catalytic residues found... , became strikingly less accessible to protease digestion in the presence of abasic site-containing DNA... of the nuclease fold, there must be multiple means by which DNA containing an ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
11 Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases and REV1
 

Summary:  is a deoxycytidyl transferase that shows the highest catalytic activity opposite template guanines and abasic sites... (14, 15). Rev1 is primarily responsible for inserting dC residues opposite abasic sites during... oligonucleotide-based system was used in which the template strand contained a model ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
12 A Core Folding Model for Catalysis by the Hammerhead Ribozyme Accounts for Its Extraordinary Sensitivity to Abasic Mutations
 

Summary:  Sensitivity to Abasic Mutations Alessio Peracchi,,§ Alexander Karpeisky,| Lara Maloney,| Leonid Beigelman... ReceiVed April 17, 1998; ReVised Manuscript ReceiVed August 4, 1998 ABSTRACT: Introducing abasic... and larger ribozymes are described herein. The deleterious effects of the abasic mutations are not relieved

  

Source: Herschlag, Dan - Department of Biochemistry, Stanford University

 

Collection: Biology and Medicine

 
13 Noncovalent Spin Labeling DOI: 10.1002/anie.201002637
 

Summary:  ,7] The strategy for noncovalent labeling was to disconnect the glycosidic bond of C¸ to give an abasic site (F... ) and the free spin-labeled base ç (Figure 1). The spin label would bind in the abasic site through receptor... containing an abasic site with ç, a ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
14 Effect of lesions on the dynamics of DNA on the picosecond and nanosecond timescales using a
 

Summary:  that this abasic site does not induce a major structural change in the helix. This result contrasts with ®ndings... DNA: an abasic site and a helix terminus. Because these comparisons are looking for small effects... of the oligonucleotides (Fig. 1). When paired with a tetrahydrofuran ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
15 Dissociative electron attachment to abasic DNA Sylwia Ptasin ska* and Le on Sanche
 

Summary:  by the presence of an abasic site; in both XCAT and GCXT, the yield of detached bases was found to be up... by investigating anion desorption induced by 3­15 eV electrons on thin films of the abasic tetramers XCAT, GXAT... not depend very much on the presence of an abasic ...

  

Source: Simons, Jack - Department of Chemistry, University of Utah

 

Collection: Chemistry

 
16 Human Apurinic/Apyrimidinic Endonuclease Is Processive, Daniel C. Carey and Phyllis R. Strauss*
 

Summary:  abasic sites in the base excision repair pathway. AP endo makes a single nick 5 to an abasic site... in double-stranded DNA. In this study, we investigated whether AP endo locates an abasic site through... a processive or a distributive mechanism. We used a linear ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
17 A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli
 

Summary:  pair or an abasic site, we found a small number of proteins that could recognize each type of probe... 7 N = Control A:C mismatch G:T mismatch Abasic site:G Abasic site:A Abasic site:C Abasic ...

  

Source: Chen, Chien-Sheng - Institute of Systems Biology and Bioinformatics, National Central University

 

Collection: Biology and Medicine

 
18 3-Methyladenine DNA glycosylases: structure,
 

Summary:  to produce an abasic site. The abasic site is then processed by one of two pathways, termed short... generates a DNA strand break at the abasic site and the abasic terminus is removed by deoxyribo- phosphatase... by a replicative polymerase.AP ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
19 Base Excision and DNA Binding Activities of Human Alkyladenine DNA Glycosylase Are Sensitive to the Base Paired with a Lesion*
 

Summary:  affinity of human alkylad- enine DNA glycosylase to a DNA product containing an abasic site was similar... , it had no effect when placed opposite G or A. Binding of hAAG 79 to DNA Duplexes Containing Abasic Sites... substrates containing a synthetic abasic site was ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
20 Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells
 

Summary:  of an abasic site (29, 30). To obtain clear evidence that leinamycin-induced DNA strand breaks may... to generate SSBs via a -elimination reaction that cleaves the O-P bond on the 3- side of the abasic site (22... spontaneously occur via -elimination reactions at aldehydic ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry


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21 Substrate Binding by Human Apurinic/Apyrimidinic Endonuclease Indicates a Briggs-Haldane Mechanism*
 

Summary:  Apurinic/apyrimidinic endonuclease (AP endo) makes a single nick 5 to a DNA abasic site. We have character... the abasic site during treatment with uracil-DNA glycosylase with a reducing agent. Otherwise, a 20-mer... M and 10 s 1 , respectively. Heat treatment of the abasic ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
22 INTRINSIC PROPERTIES OF THE TWO REPLICATIVE DNA POLYMERASES OF PYROCOCCUS ABYSSI IN REPLICATING ABASIC SITES: POSSIBLE ROLE IN DNA
 

Summary:  39 40 41 Spontaneous and induced abasic sites in hyperthermophiles DNA have long been suspected... ABASIC SITES: POSSIBLE ROLE IN DNA DAMAGE TOLERANCE ? 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20... , France. Running Tittle : DNA synthesis by Pabpols of DNA containing ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
23 Proliferating Cell Nuclear Antigen Promotes Translesion Synthesis by DNA Polymerase *
 

Summary:  by Pol on undamaged DNA. PCNA also stimulated translesion synthesis of a model abasic site by Pol... experimental conditions, facile by- pass of the abasic site was also detected by DNA polym- erase or (Rad30... Synthesis of a Model Abasic Site--To determine which ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
24 Cell, Vol. 95, 249258, October 16, 1998, Copyright 1998 by Cell Press Crystal Structure of a Human Alkylbase-DNA
 

Summary:  ., 1997; David and Williams, 1998). The resultingBoston, Massachusetts 02115 abasic (AP) sites are further... nucleotide to flip into the en- sylase reaction, a pyrrolidine abasic nucleotide, which zyme active site... ) on either side of the pyrrolidine site (Fig- either side of the ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
25 Molecular Cell, Vol. 20, 367375, November 11, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.molcel.2005.09.018 MRE11/RAD50 Cleaves DNA
 

Summary:  by deamination of cytosine to uracil, followed by removal of uracil to create an abasic (AP) site. We find... in the hypermutation mecha- nism, and that purified, recombinant MRE/RAD50 (MR) can cleave DNA at abasic sites... can cleave at abasic sites, we adopted a ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
26 DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG)
 

Summary:  to other glycosylase-DNA structures, the abasic ri- bose is not flipped into the TAG active site... a tetrahydrofuran (THF) abasic site analog. The THF moiety is isosteric with enzymatically generated apuri- nic... -chain and main- chain atoms from the HhH motif bind the phosphate groups 30 to the ...

  

Source: Eichman, Brandt F. - Department of Biological Sciences, Vanderbilt University

 

Collection: Biology and Medicine

 
27 Site-Directed Spin-Labeling of Nucleic Acids by Click Chemistry: Detection of Abasic Sites in Duplex DNA by EPR
 

Summary:  Site-Directed Spin-Labeling of Nucleic Acids by Click Chemistry: Detection of Abasic Sites... that can detect and identify local structural deformations in duplex DNA, in particular abasic sites... , for the first time, abasic sites in duplex DNA ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
28 Genome Biology 2004, 5:211 commentreviewsreportsdepositedresearchinteractionsinformationrefereedresearch
 

Summary:  removes U, leaving an abasic site. Subsequent steps generate single-strand breaks [17], which become... endonucleases to nick the abasic site so that new DNA synthe- sis can recreate the duplex [6]. Reasoning... , and that uracil-DNA glyco- sylase removes U to produce an abasic ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
29 Pure Appl. Chem., Vol. 83, No. 3, pp. 677686, 2011. doi:10.1351/PAC-CON-10-09-28
 

Summary:  on noncovalent interactions between a spin-labeled nucleobase and an abasic site in duplex DNA. Keywords: EPR... Postsynthetic spin labeling of nucleobases by click chemistry: Detection of abasic sites The success... been used to detect abasic sites in DNA [21], ...

  

Source: Sigurdsson, Snorri Thor - Chemistry Division, Science Institute, University of Iceland.

 

Collection: Chemistry

 
30 DNA Damage Induced by Low-Energy Electrons: Electron Transfer and Diffraction Yi Zheng, J. Richard Wagner, and Leon Sanche*
 

Summary:  of GCXTand XCATwhere X represents a stable abasic site in which the base is replaced by a hydrogen atom... of the backbone at sites that are distant from the abasic site (i.e., in the yield functions pCXT, Gp, p... , the 10 eV resonance at sites 8 and 9 associated ...

  

Source: Simons, Jack - Department of Chemistry, University of Utah

 

Collection: Chemistry

 
31 Single-Turnover Analysis of Mutant Human Apurinic/Apyrimidinic Endonuclease, Julie A. Lucas, Yuji Masuda,|, Richard A. O. Bennett,| Nathaniel S. Strauss,,@ and Phyllis R. Strauss*,
 

Summary:  and cleavage of abasic site-containing DNA. Apurinic/apyrimidinic endonuclease (AP endo) is a human enzyme... that is critical to the repair of abasic sites in DNA arising through either base excision repair or oxidative... damage. AP endo recognizes abasic sites in ...

  

Source: Strauss, Phyllis R. - Department of Biology, Northeastern University

 

Collection: Biology and Medicine

 
32 DNA Repair 1 (2002) 645659 The S. cerevisiae Mag1 3-methyladenine DNA glycosylase
 

Summary:  the galactose-inducible GAL1 pro- moter leads to increased abasic site-induced point mutations [32]. Thus, we... , suggesting that uncleaved abasic sites generated by MAG1 can induce recombination. Nevertheless, it remains... pos- sible that single strand breaks, ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
33 Two distinct modes of RecA action are required for DNA polymerase V-catalyzed translesion synthesis
 

Summary:  in nucleotide incor- poration either directly opposite a lesion or at undamaged tem- plate sites... , and subsequently at a site immediately downstream of the lesion, where RecA mode 2 cocatalyzes lesion bypass. We... to a site of DNA damage and to stabilize the pol V-RecA interaction at the lesion. However, it is only a Rec

  

Source: Cox, Michael M. - Department of Biochemistry, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
34 An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals
 

Summary:  Backbone 1749 2.4. Properties of Abasic Sites Arising from Depurination 1749 3. Overview: Common Reactions... ). The oxocarbenium ion undergoes subsequent hydrolysis to yield an abasic site 7 (often referred to as an apurinic... site or AP site). It is calculated that ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
35 Investigating the Role of the Little Finger Domain of Y-family DNA Polymerases in Low Fidelity Synthesis and Translesion Replication*
 

Summary:  an abasic site and a thymine-thymine cyclobutane pyrimidine dimer, and predominantly makes base pair... -thymine cyclobutane pyrimidine dimers (CPDs) (15, 18, 19) and abasic sites (15, 20). In contrast, Dbh is a much more... , and bypasses an abasic site with very low ...

  

Source: Ling, Hong - Department of Biochemistry, University of Alberta

 

Collection: Biology and Medicine

 
36 NATURE BIOTECHNOLOGY VOL 17 JULY 1999 http://biotech.nature.com 639 When Cinderella disappeared in great haste
 

Summary:  . In their experiments, a comparison was made between incorporation efficien- cies of pyrene opposite the abasic site... -pair analog consisting of pyrene opposite an abasic site in B-form geometry (Courtesy E.T. Kool). © 1999... to be useful in an in vivo fluorescence assay, both for quantitative analysis of ...

  

Source: Gray, Jeffrey J. - Department of Biomolecular and Chemical Engineering, Johns Hopkins University; Ostermeier, Marc - Department of Biomolecular and Chemical Engineering, Johns Hopkins University

 

Collection: Biology and Medicine ; Biotechnology ; Chemistry

 
37 DNA polymerases in adaptive immunity Jean-Claude Weill and Claude-Agns Reynaud
 

Summary:  . Effectively, the action of UNG is restricted to uracil excision, giving rise to abasic sites, and... lesions that induce a stalling (pausing) of the replication fork. Because of their relaxed catalytic sites... -passing abasic sites, one should expect that ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
38 Chemistry & Biology, Vol. 12, 357369, March, 2005, 2005 Elsevier Ltd All rights reserved. DOI 10.1016/j.chembiol.2004.12.011 Delineation of the Chemical Pathways Underlying
 

Summary:  breaks, abasic sites, and base lesions induced and effective measure of recombination at a single lo... of induced recombination appears to decline cally induced single-strand breaks, abasic sites, and (compare 0... induce ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
39 Direct Real Time Observation of Base Flipping by the EcoRI DNA Methyltransferase*
 

Summary:  for the binding of the methyltransferase to DNA containing abasic sites or base analogs incorpo- rated... (purine), or a stable abasic site (spacer)); bot- tom strands, d(CCGCGAATTCCGCC), d(CCGCGAATTCCGCC), and d... active site. The ener- getics and kinetics of base flipping by the EcoRI ...

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine

 
40 The Coupling of Tight DNA Binding and Base Flipping IDENTIFICATION OF A CONSERVED STRUCTURAL MOTIF IN BASE FLIPPING ENZYMES*
 

Summary:  for the binary structure with AdoMet and the tertiary structure with an abasic target site (see red and black... -crystal structure of the cognate cytosine target site (3MHT) and the abasic target site (9MHT), and this net... 3 Ala mutant and the tight binding of ...

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine


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41 Z .Mutation Research 460 2000 201210 www.elsevier.comrlocaterdnarepair
 

Summary:  then expose the target nu- cleotide and cleave the glycosylic bond. The result- ing abasic site is processed... out 1-azaribose abasic nucleotide in the active site of AlkA shows that the 3-methyl- adenine base... , abasic site, base mismatch the probe, Leu125 in AlkA ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
42 A Ubiquitin-binding Motif in the Translesion DNA Polymerase Rev1 Mediates Its Essential Functional Interaction with
 

Summary:  and abasic sites (30, 31). This enzyme is primarily respon- sible for inserting dC residues opposite abasic... sites during mutagenesis (25, 32, 33). Although the requirement for PCNA mono-ubiquitination in damage-induced... such on the template that Rev1 has to insert one dCMP opposite ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
43 DEMETER DNA Glycosylase Establishes MEDEA Polycomb Gene Self-Imprinting
 

Summary:  -glycosylic bond, creating an abasic site, whereas the lyase activity nicks the DNA. An AP endonuclease generates... of the phospho- diester bonds (Figure 3A). Cleavage 50 to the abasic site of the b or d elimination produced... , perhaps due to the formation of mutagenic abasic ...

  

Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
44 Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase*S
 

Summary:  at the pause sites. Pre-steady State Kinetic Studies of Abasic Lesion Bypass MARCH 16, 2007·VOLUME 282·NUMBER... Mechanism of Abasic Lesion Bypass Catalyzed by a Y-family DNA Polymerase*S Received for publication... in vivo. These unrepaired abasic lesions are expected to be bypassed by Dpo4, the only ...

  

Source: Suo, Zucai - Department of Biochemistry, Ohio State University

 

Collection: Biology and Medicine

 
45 Molecular basis for discriminating between normal and damaged bases by the human alkyladenine
 

Summary:  be distinguished from normal DNA bases in the enzyme active site. Mutational analyses of residues contacting... , and the resulting abasic nucleotide is excised and replaced with a normal nucleotide by the sequential action... , the pyrrolidine abasic nucleotide (pyr; PDB ID code 1bnk; refs. 15 and 16). In the AAG pyr-DNA complex, ...

  

Source: Lau, Albert Y. - Department of Biophysics and Biophysical Chemistry, Johns Hopkins University

 

Collection: Biology and Medicine

 
46 Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction1
 

Summary:  at a defined position in the oligonucleotide), processing of the abasic site, incorporation of the new... ) and processing of the resulting abasic site by AP endonuclease. These activities were measured as percent... controls (Fig. 1). 2. Caloric restriction induces subtle increases in ...

  

Source: Stuart, Jeffrey A. - Department of Biological Sciences, Brock University

 

Collection: Biology and Medicine

 
47 Guidelines for Research Studies in the Emergency Department A primary goal of the Arizona Emergency Medicine Research Center (AEMRC) is to
 

Summary:  of Emergency Department and AEMRC expenses. Obtain site authorization for the study from the AEMRC. Prior... in such a way that it does not represent an inappropriate inducement leading to care providers being coercive... and will include at least 10 patients. Core cost calculations are abased on 45 minutes per 15 participating

  

Source: Arizona, University of - Center for Gamma-Ray Imaging

 

Collection: Engineering ; Biology and Medicine

 
48 ANRV260-GE39-03 ARI 21 June 2005 22:14 Immunoglobulin Gene
 

Summary:  , abasic endonucleases nick the phosphodi- ester backbone at the abasic site, DNA poly- merase synthesizes... the phosphodiester backbone at the abasic site, and DNA polymerase and ligases repair the gap. AID Deaminates Single... is the fate of the abasic ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
49 Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase
 

Summary:  is replaced with an abasic site (Table 2). F84A is decreased dramatically in catalysis as well (Table 3, 1000... -GGGAATTCATGG^GCAGTGGGTGGATCCAG-3 3-CCCTTAAGTACCGCMe GTCACCCACCTAGGTC-5 (caret=abasic site) were used... by disrupting interactions at a hydrophobic interface between the active ...

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine

 
50 Small interfering RNAs (siRNAs) can target the RNA interference (RNAi)
 

Summary:  or uracil from G·T and G·U mismatches and remains stably bound to the resulting abasic site until... the abasic site, and the 2.1-Å-resolution crystal structure of the central region of human TDG conjugated... - mosomal regions where it induces chromatin modifications and tran- ...

  

Source: Nelson, Celeste M. - Departments of Molecular Biology & Chemical Engineering, Princeton University

 

Collection: Biology and Medicine ; Biotechnology

 
51 Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
 

Summary:  to be a promising candidate for replication by base filling since the abasic reaction site is a versatile secondary... -PNA duplexes.8,9 We found that incorporation of an abasic site had a parallel, though more dramatic effect... of the duplex) (Table 1). Next we tested the ability of PNA bases to fill a ...

  

Source: Liu, David R. - Department of Chemistry and Chemical Biology, Harvard University

 

Collection: Chemistry ; Biology and Medicine

 
52 Oxidative DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)
 

Summary:  (endo IV), and abasic sites (exo III and endo IV) into strand breaks (Fig. 1).23,25,26 The base excision... duplex DNA (Fig. 1) and also catalyze subsequent strand clea- vage at the resulting abasic site (Scheme 2... that abasic sites and/or C10 -oxidized ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
53 New Programs From Old G. RAMALINGAM and THOMAS REPS
 

Summary:  by G/s, is a graph induced by all vertices on which s has a transitive flow or control dependence... program­modification operations; D (a,base) yields the program modification performed on base to obtain... apply( D (a,base) + D (b,base), base). The UNIX 2 utility diff yields a simple example of a modification

  

Source: Liblit, Ben - Department of Computer Sciences, University of Wisconsin at Madison

 

Collection: Computer Technologies and Information Sciences

 
54 Homologous recombination prevents methylation-induced toxicity in Escherichia coli
 

Summary:  glycosylases remove methylated bases (filled circle) and the resulting abasic site is recognized and cleaved... formation. (C) Depurination of methylated bases results in the formation of abasic sites which... -endonucleases presumably owing to the pres- ence of abasic ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
55 MOLECULAR AND CELLULAR BIOLOGY, Sept. 2002, p. 64806486 Vol. 22, No. 18 0270-7306/02/$04.00 0 DOI: 10.1128/MCB.22.18.64806486.2002
 

Summary:  endonuclease activity and functions in the removal of abasic sites from DNA. Here, we provide evidence... - ified miscoding bases, abasic (AP) sites, and DNA strand breaks. AP sites are some of the most common... tetrahydrofuran, an abasic site ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
56 New Programs From Old G. RAMALINGAM and THOMAS REPS
 

Summary:  to s, denoted by G/s, is a graph induced by all vertices on which s has a transitive flow or control... program­modification operations; D (a,base) yields the program­modification performed on base to obtain... = apply( D (a,base) + D (b,base), base). The UNIX 2 utility diff yields a simple example of a modification

  

Source: Liblit, Ben - Department of Computer Sciences, University of Wisconsin at Madison

 

Collection: Computer Technologies and Information Sciences

 
57 Molecular Cell, Vol. 15, 607620, August 27, 2004, Copyright 2004 by Cell Press The Fanconi Anaemia Gene FANCC Promotes
 

Summary:  approach to identifyenously generated abasic sites. Moreover in these ver- the type of repair defect in FA... for the repair of endogenously generated abasic sites in theseen in human FA cells. FANCC knockout (KO) cells... Lines Have Reduced Templated and Untemplated Changes in Response to Endogenously ...

  

Source: Patel, KJ - Laboratory of Molecular Biology, MRC

 

Collection: Biology and Medicine

 
58 A novel function of DNA polymerase f regulated Matthew R Northam1,3
 

Summary:  the catalytic activity of Rev1 normally functions during TLS, particularly during abasic site bypass, Received... polymerase active site abolish DNA damage-induced mutagenesis (Pavlov et al, 2001b). Biochemical studies have... of UV-damage, we next investigated bypass of a model abasic ...

  

Source: Burgers, Peter M. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
59 PRINCIPAL ANGLES BETWEEN SUBSPACES IN AN A-BASED SCALAR PRODUCT: ALGORITHMS AND PERTURBATION
 

Summary:  PRINCIPAL ANGLES BETWEEN SUBSPACES IN AN A-BASED SCALAR PRODUCT: ALGORITHMS AND PERTURBATION... the method to the computation of principal angles in an A-based scalar product for a symmetric and positive... · denotes the standard Euclidean norm of a vector or, when applied to a matrix, the corresponding induced

  

Source: Knyazev, Andrew - Department of Mathematics, University of Colorado at Denver

 

Collection: Mathematics

 
60 Site-selective depurination by a periodate-dependent deoxyribozyme{ Claudia Hobartner, P. I. Pradeepkumar and Scott K. Silverman*
 

Summary:  amination of the 39-NH2 oligonucleotide with the resulting abasic site (1). The initially unmasked aldehyde... nucleobase of G2 could be lost, leading to an abasic site that cannot be oxidized to a dialdehyde (2). Third... /z value. Therefore, we conclude that NaIO4 induces ...

  

Source: Pradeepkumar, P. I. - Department of Chemistry, Indian Institute of Technology Bombay; Silverman, Scott K. - Department of Chemistry, University of Illinois at Urbana-Champaign

 

Collection: Biology and Medicine ; Chemistry


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61 dna repair 5 ( 2 0 0 6 ) 294302 available at www.sciencedirect.com
 

Summary:  , oxidative base damage, covalent base modifications by enzymes, and spontaneously generated abasic sites... spontaneous mutations [34]. DNA polymerase efficiently bypasses abasic site, 2-acetyl- aminofluorene (AAF... is biased toward generation of frameshift mutations [53­55]. They proficiently bypass ...

  

Source: Bielas, Jason H. - Bielas, Jason H. - Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington at Seattle

 

Collection: Biology and Medicine

 
62 Multiple Cleavage Activities of Endonuclease V from Thermotoga maritima: Recognition and Strand Nicking Mechanism
 

Summary:  , an inducible AP endonuclease in E. coli, recognizes a doubly flipped AP site; i.e., both the abasic sugar... the uracil base and with AP endonucleases and other enzymes to repair the subsequent abasic site (4, 5... that E. coli endoV plays a significant role in deoxyinosine and ...

  

Source: Barany, Francis - Biochemistry and Structural Biology Program, Weill Cornell Graduate School of Medical Sciences

 

Collection: Biology and Medicine

 
63 In vivo Recombination After Chronic Damage Exposure Falls to Below Spontaneous Levels in ``Recombomice''
 

Summary:  of recombinogenic strand breaks and abasic sites. As a first step toward revealing the molecular basis... #12;yield abasic sites that are subsequently repaired by downstream BER enzymes (44). It is well... established that conditions that result in increased levels of BER intermediates, such as ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
64 JOURNAL OF BACTERIOLOGY, July 2002, p. 35013507 Vol. 184, No. 13 0021-9193/02/$04.00 0 DOI: 10.1128/JB.184.13.35013507.2002
 

Summary:  and the deoxyribose, resulting in an abasic (AP) site. Subsequently, AP endonucleases incise the DNA backbone... sites must be above a certain threshold in order to be toxic. Ung and Fpg convert NO. -induced base... ). Both AP sites and single-strand breaks can induce ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
65 Cell, Vol. 110, 3342, July 12, 2002, Copyright 2002 by Cell Press DEMETER, a DNA Glycosylase Domain Protein,
 

Summary:  that generates an abasic site by carrying out a base excision reaction. The next step in DNA repair is single... -stranded DNA cleavage (nicking) 5 to the abasic site by an AP endonu- clease (Bruner et al., 2000; Jiricny... gene in an abasic site that is mutagenic and ...

  

Source: Goldberg, Robert B. - Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles

 

Collection: Biology and Medicine

 
66 Number 23 1995 Los Alamos Science Radiation, Cell Cycle, and Cancer
 

Summary:  carcinogens, and its ability to induce cancer is not in doubt. The tragic experiences of the radium... of radiation well below the lethal dose can induce behavior that will eventually lead to the death of an entire... capacity to induce genetic mutations, can bring about a change in the basic nature of the cell. The cell

  

Source: Massey, Thomas N. - Department of Physics and Astronomy, Ohio University

 

Collection: Physics

 
67 University of Maryland Baltimore Graduate School Announcement of Doctoral Dissertation Defense
 

Summary:  of these damaged bases result in the formation of an abasic or AP site, allowing the next enzyme in the pathway... , Apurinic/Apyrimidinic Endonuclease 1 (APE1), to hydrolytically cleave the DNA backbone 5' to the AP site... binding sites for two redox (another APE1 function) inhibitors of APE1, one of which ...

  

Source: Weber, David J. - Department of Biochemistry and Molecular Biology, University of Maryland-Baltimore

 

Collection: Biology and Medicine

 
68 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  bulky DNA adducts (i.e. benzopyrenes) [49], whereas thiamine dimers, abasic sites, and ROS- mediated... of the enzyme. A potentially mutagenic and/or cytotoxic abasic site (lack- ing the base moiety) is generated... endonucleases, DNA ligase, and DNA polymerases. Furthermore, if abasic ...

  

Source: Collins, James J. - Wyss Institute for Biologically Inspired Engineering & Department of Biomedical Engineering, Boston University

 

Collection: Engineering ; Biotechnology

 
69 Chemical Properties of the Leinamycin-Guanine Adduct Tony Nooner, Sanjay Dutta, and Kent S. Gates*
 

Summary:  sites in DNA under physi- ological conditions. Abasic sites, and the strand breaks... of the abasic sites generated by depurination of the leina- mycin-guanine adduct. This suggestion is spurred... ), thus render- ing cells hypersensitive to the effects of abasic ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
70 JOURNAL OF BACTERIOLOGY, 0021-9193/01/$04.00 0 DOI: 10.1128/JB.183.1.131138.2001
 

Summary:  of abasic sites is critical for defense against NO. In addition, recA mutant cells were exquisitely... /apurinic (AP) endonucleases at the abasic site. This results in a 3 -OH terminus, which can act as a primer... - nates, with a half-life of 4 h, to form abasic sites ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
71 RNA folding and the origins of catalytic activity in the hairpin ribozyme Timothy J. Wilson a
 

Summary:  activity [26], while 10,000-fold loss of activity resulted from an abasic site at position 38 [27... 756 to the site of cleavage in the substrate was demonstrated by the formation of a UV-induced... of abasic sites in the core of the hammerhead ribozyme showed that ...

  

Source: Ha, Taekjip - Department of Physics, University of Illinois at Urbana-Champaign

 

Collection: Physics ; Chemistry ; Biology and Medicine

 
72 AID in antibody perfection A.C. Vallura
 

Summary:  an abasic site for further repair. Neuberger and colleagues reasoned that if AID deaminates DNA directly... opposite U, at abasic sites, or in the course of repair [58]. However, there is no evidence thus far... ­14, 59, 60] or another uracil DNA glycosylase, SMUG1 [61] generates an ...

  

Source: Maizels, Nancy - Department of Biochemistry, University of Washington at Seattle

 

Collection: Biology and Medicine

 
73 Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis
 

Summary:  in the active site is near-native. When tested with an abasic or CPD lesions, the effects of Mn2 þ on relaxing... extension. Bypass of (C) a synthetic abasic site and (D) a cis-syn CPD. (E) Terminal nucleotidyl transferase... incoming nucleotide with its preformed and open active site. ...

  

Source: Ling, Hong - Department of Biochemistry, University of Alberta

 

Collection: Biology and Medicine

 
74 Correlation of mitochondrial superoxide dismutase and DNA polymerase b in mammalian dermal fibroblasts with species maximal lifespan
 

Summary:  in parallel to APE activity assays: the addition of control oligonucleotide (no abasic site analogue); no cell... damage, abasic sites, and single strand breaks, are removed via the short-patch BER pathway. In mammals... , is responsible for further processing abasic ...

  

Source: Stuart, Jeffrey A. - Department of Biological Sciences, Brock University

 

Collection: Biology and Medicine

 
75 Advertisements Info for Advertisers
 

Summary:  -Based Detection of C4-Oxidized Abasic Sites at Specific Positions in DNA Fragments Goutam Chowdhury and F. Peter... 700164y Fluorescence Probing of Aminofluorene-Induced Conformational Heterogeneity in DNA Duplexes Nidhi... Jain, Yana K. Reshetnyak, Lan Gao, M. Paul Chiarelli and Bongsup P. Cho DOI: 10.1021/tx7003536 ...

  

Source: Gates, Kent. S. - Departments of Chemistry & Biochemistry, University of Missouri-Columbia

 

Collection: Chemistry

 
76 The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI
 

Summary:  exploit complex structural mechanisms to gain access to the target site of catalysis, including DNA... methods.11­13 S-Adenosyl-L-methionine (AdoMet)-dependent sequence-specific DNA methyltransferases induce... into DNA,2,15,16 and exploit base flipping in their site-specific modifica- tion of DNA.17,18 The first

  

Source: Reich, Norbert O. - Department of Chemistry and Biochemistry, University of California at Santa Barbara

 

Collection: Chemistry ; Biology and Medicine

 
77 Majorization for Changes in Ritz Values and Canonical Angles Between Subspaces
 

Summary:  between Subspaces in an A-Based Scalar Product: Algorithms and Perturbation Estimates, SIAM Journal... . Generalization to an A­Based Scalar Product 4. Numerical Examples 5. Conclusions #12;4 1. Angles Between... )/k, if k = 0, k = 1, . . . , q. #12;10 3. Generalization to an A­Based Scalar Product Let A Rn

  

Source: Knyazev, Andrew - Department of Mathematics, University of Colorado at Denver

 

Collection: Mathematics

 
78 Proc. Natl. Acad. Sci. USA Vol. 94, pp. 1308713092, November 1997
 

Summary:  is followed by strand cleavage in the vicinity of the abasic site (by AP endonuclease or AP lyase... -mercaptoethanol in a total volume of 30 L. DNA was chemically cleaved at abasic sites (0.1 N NaOH, 90°C, 4 min... at abasic sites and analyzed by denaturing PAGE. ...

  

Source: Engelward, Bevin - Division of Bioengineering, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
79 RecA acts in trans to allow replication of damaged DNA by DNA polymerase V
 

Summary:  . 1b, lane 3). Pol V typically copies past DNA lesions--for example, abasic sites ("X" in Fig. 1c... of the DNA lesion (an abasic site). d, Transactivation of pol V synthesis on a DNA hairpin containing a 50... was calculated by dividing the number of hairpins extended past the abasic ...

  

Source: Cox, Michael M. - Department of Biochemistry, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
80 DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from
 

Summary:  , followed by abasic site processing, gap-®lling and ligation of the DNA strand. Mammalian mitochondria... endonuclease IV, to ensure complete cleavage of abasic sites. Reactions were terminated by addition of 20 ml... - stranded, containing an 8-oxodG; THF = double-stranded, containing a THF ...

  

Source: Stuart, Jeffrey A. - Department of Biological Sciences, Brock University

 

Collection: Biology and Medicine


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81 Molecular dynamics of B DNA Supplementary Animations
 

Summary:  entirely out of the double helical stack, thereby eliminating the (A·T)13 base pair and forming an abasic... and TTCC B half sites which together comprise the nonameric 5' AGAANTTCC3' DNA recognition element for (c

  

Source: Mura, Cameron - Department of Chemistry, University of Virginia

 

Collection: Chemistry

 
82 TheJournalofExperimentalMedicine JEM The Rockefeller University Press $8.00
 

Summary:  that ensure the replication bypass of abasic sites that failed to be corrected by the classical base excision... the uracils or the abasic sites generated by uracil glycosylase, both events occurring on the DNA strand... opposed to the lesion and without repair. Replication over the ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
83 Formal Verification of Control Software: A Case Study
 

Summary:  to be halted while a technician travels to the site to repair the problem. The design of concurrent software... with a set of properties to Java. #12;1 SEQUENCE Handling 2 3 STEP A.Base_0: 4 Hold1.Base(); 5 Hold2.Base... (); 6 NEXT_STEP; 7 8 9 STEP A.Base_1: 10 IF Hold1.InBase() AND 11 Hold2.InBase() THEN 12 Vert.Work(); 13

  

Source: Technische Universität Graz, Institute for Software Technology

 

Collection: Computer Technologies and Information Sciences

 
84 Integration Requires a Specific Interaction of the Donor DNA Terminal 5 -Cytosine with Glutamine 148 of the HIV-1
 

Summary:  binding by 5CITEP was examined by using 5 -32 P-labeled oligonucleotide containing an abasic site (X... substrates are described in B and D (full-length and precleaved upper strand, respectively). An abasic site... integrase and an abasic site substitution for the ...

  

Source: Santos, Webster L. - Department of Chemistry, Virginia Tech

 

Collection: Chemistry

 
85 Analysis of the RNA-Editing Reaction of ADAR2 with Structural and Fluorescent Analogues of the GluR-B R/G Editing Site
 

Summary:  for an ADAR-induced base flipping. Herein we describe the generation of R/G editing site analogues from Glu... both strands of duplex DNA over the 6 bp that surround an abasic site, where it flips out both... the abasic nucleotide and the nucleotide across the duplex, cleaving the strand ...

  

Source: Beal, Peter A. - Department of Chemistry, University of Utah

 

Collection: Chemistry

 
86 ALGEBRAIC L-T}~0RY III. TWISTED LAUREI~ EXTENSIONS
 

Summary:  the inclusion of A in A , and C is induced by I-~ . For A = Z[~] it is possible to identify L~(~) = Vn(Z[x 2... ',x,a)~----+a'.x.f(a) The induced functor f .p(A) .... ~(~) ; is such that and e A'). ~p I -~fp = A'@Ap ~geliomA(P,~) ~ I ®g6Hom A... -preserving morphism of rinks with involution f : A ~.A' induces morphisms_of abelian ...

  

Source: Ranicki, Andrew - School of Mathematics, University of Edinburgh

 

Collection: Mathematics

 
87 New Concepts in Biochemistry Deoxyribose Phosphate Excision by the N-Terminal Domain of the Polymerase
 

Summary:  : enforced contacts between 8 kDa domain and the 5 dRP group of the AP site and an induced fit mechanism... tripeptide of the sequence Lys-Trp(Tyr)-Lys can promote -elimination at an aldehydic abasic site in DNA... an activity for excising a 5-deoxyribose phosphate (dRP) group from preincised ...

  

Source: Crasto, Chiquito - Department of Genetics, University of Alabama at Birmingham

 

Collection: Biology and Medicine

 
88 Role of the Arabidopsis DNA glycosylase lyase ROS1 in active DNA demethylation
 

Summary:  - and -elimination reactions at the abasic site, after it removes the methylated cytosine base. A weak cleavage... activity then nicks the DNA backbone at the abasic site. Our results suggest that this lyase activity... removes the deoxyribose from the nicked abasic ...

  

Source: Zhu, Jian-Kang - Institute for Integrated Genome Biology, University of California at Riverside

 

Collection: Biotechnology

 
89 Molecular Cell Deubiquitination of FANCD2 Is Required
 

Summary:  by abasic sites formed by the concerted action of activation-induced deaminase (AID) and uracil DNA... glycosylase (UNG) (Di Noia and Neu- berger, 2002; Di Noia et al., 2006). Abasic-site-induced gene conversion... et al., 2004). Point mutation is dependent on mutagenic bypass of the ...

  

Source: Patel, KJ - Laboratory of Molecular Biology, MRC

 

Collection: Biology and Medicine

 
90 Coumarin base-pair replacement as a fluorescent probe of ultrafast DNA dynamics
 

Summary:  was covalently attached in silico via C4 to the C10 position of an opposed abasic-site tetrahydro- furan analog... Figure 1. Structure of photoprobe Coumarin 102. O O O O O O NOO -C-glycoside abasic site 4 1 Figure 2... . Coumarin C-glycoside/abasic-site tetrahydrofuran. 3451R. S. Coleman et al. / Tetrahedron ...

  

Source: Coleman, Robert S. - Department of Chemistry, Ohio State University

 

Collection: Chemistry

 
91 Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2
 

Summary:  of 10-3 to 10-4 when synthesizing undamaged DNA and can traverse various lesions, such as abasic sites... - plex with an abasic site (Ling et al. 2004a). While recent pre-steady-state kinetic data (Fiala and Suo... of Dpo4 with DNA and incoming nucleotide ddATP opposite an abasic ...

  

Source: Schlick, Tamar - Department of Chemistry, New York University

 

Collection: Chemistry

 
92 Math. Z. (2007) 255:451491 DOI 10.1007/s00209-006-0004-4 Mathematische Zeitschrift
 

Summary:  R( ·) is the space of closed forms. On the level of cohomology, z induces an algebra homomorphism w : S(g )G H d... -differen- tial algebra W(h) (P), which induces a map zBT : S(g)G W(h) (M) H-basic . On the other hand, P can... -connection. Our construction in Sect. 6 induces a map z : S(g)G Z((H × M)·). We have Theorem C ...

  

Source: Tu, Jean-Louis - Laboratoire et Département de Mathématiques, Université de Metz

 

Collection: Mathematics

 
93 2000 Macmillan Magazines Ltd letters to nature
 

Summary:  abasic site analogs and site-directed mutagenesis. J. Mol. Biol. 290, 447±457 (1999). 13. Izumi, T. et al... . & Grollman, A. P. Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA... , J. P., Barsky, D., Scharer, O. D., Colvin, M. E. & Wilson, D. M. ...

  

Source: Engelman, Donald M.- Department of Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
94 DNA Distortion and Specificity in a Sequence-Specific Endonuclease
 

Summary:  titration did not provide sufficient signal. Therefore, DNA containing abasic sites within the cognate... an abasic site on each strand in the HincII recognition sequence. Figure 6b shows the change in polarization... using the same HEX-labeled abasic site duplex at ...

  

Source: Horton, Nancy C. - Department of Chemistry and Biochemistry, University of Arizona

 

Collection: Biology and Medicine ; Chemistry

 
95 ANRV329-GE41-06 ARI 4 June 2007 17:56 Immunoglobulin Somatic
 

Summary:  June 2007 17:56 traverses UNG-induced abasic sites to pro- mote transversions at C:G pairs (22... from the DNA backbone results in a noninstruc- tive abasic site, replication of which allows... ), and that the low-fidelity polymerase (pol) can in- troduce both transitions and ...

  

Source: Papavasiliou, F. Nina - Laboratory of Lymphocyte Biology, Rockefeller University

 

Collection: Biology and Medicine

 
96 Mitochondrial DNA maintenance and bioenergetics Jeffrey A. Stuart , Melanie F. Brown
 

Summary:  with streptozotocin, an alkylating antibiotic [63]. Complete repair of abasic sites has been demonstrated in vitro... -endonuclease (or alternative mechanism for processing abasic sites), DNA polymerase and DNA ligase. During... the first step of this pathway, a DNA glycosylase removes the damaged base ...

  

Source: Stuart, Jeffrey A. - Department of Biological Sciences, Brock University

 

Collection: Biology and Medicine

 
97 arXiv:math.DG/0401420v29Feb2004 Chern-Weil map for principal bundles over groupoids
 

Summary:  R(·) is the space of closed forms. On the level of cohomology, z induces an algebra homomorphism w : S(g )G H d... precisely, they constructed an H-basic connection on the G-differential algebra W(h) (P), which induces... the transformation groupoid H × M M, and (P) g as a pseudo-connection. Our construction in Section 6 ...

  

Source: Laurent, Camille - Laboratoire de Mathématiques et Applications, Université de Poitiers

 

Collection: Mathematics

 
98 Introduction More than 50 years ago, Weigle made the pivotal dis-
 

Summary:  A binding sites lose the LexA repressor last and are induced later in the response. Among these genes... , Witkin proposed that this phenomenon was evidence of a damage-induced DNA repair system in bacterial... A and recA gene functions that can account for UV-induced mutations of phage and E. coli, which he ...

  

Source: Cox, Michael M. - Department of Biochemistry, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
99 Supplementary information for The structural basis of RNA-catalyzed RNA polymerization
 

Summary:  structures) might be explained if inner-sphere coordination of Cd2+ induced a tautomeric shift... of these results assumes that the purines can be accommodated within the active site such that the N6 exocyclic... proposed in the active sites of the HDV and VS ribozymes37,39,40. Previous results from a modification

  

Source: Bartel, David - Whitehead Institute for Biomedical Research & Department of Biology, Massachusetts Institute of Technology (MIT)

 

Collection: Biotechnology ; Biology and Medicine

 
100 Forma: A Framework for Safe Automatic Array University of Alberta
 

Summary:  [k].satfield) &(Asati [k].satfield') 7 allocation site: Abase=new(N*E) A=new(N*E) for i [1, SatNum] Asati = Abase... [k].pointeri satfield') 7 allocation site: Abase=new(N*NewE) A=new(N*E) for i [1, SatNum] for j [0, N-1] Abase... of the original array. From ...

  

Source: Amaral, José Nelson - Department of Computing Science, University of Alberta

 

Collection: Computer Technologies and Information Sciences


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