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Sample search results for: abc multidrug efflux

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1 List of publications 1. Poelarends, G.J., Mazurkiewicz, P., Putman, M., Cool, R.H., van Veen,
 

Summary:  .W., and Konings, W.N. (2000). An ABC-type multidrug transporter of Lactococcus lactis possesses an exceptionally... .N., and Poelarends, G.J. (2002). Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles... a heterodimeric ABC- type ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
2 [1] Nikaido,H. (1994) Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science, 264, 382-388.
 

Summary:  ,T., Mizushima,T., & Tsuchiya,T. (2003) Molecular cloning and characterization of an ABC multidrug efflux pump... ) The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs... . Microbiol., 11, 841-847. [11] ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
3 Reduced intracellular accumulation of calcein by overexpression of fluorescent protein fusions of the multidrug transporter Sp-ABCB1a, in sea urchin (Strongylocentrotus purpuratus) embryos.
 

Summary:  Scripps Institution of Oceanography, La Jolla, CA 92037 hamdoun@ucsd.edu Multidrug efflux transporters... of specific multidrug efflux transporter gene products in sea urchin embryos. The efflux activity is measured... -A-sensitive C-AM efflux activity. Previous ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
4 EFFLUX TRANSPORTERS: Newly Appreciated
 

Summary:  of the MRP (ABCC) family also contribute to multidrug ef- flux by acting like P-gp to efflux unmodified xeno... some ABC efflux transporters, P450 detoxification proteins, and as- sociated conjugating enzymes (9... . Crit. Rev. Toxicol. 1992, 22, 23­43. (22) Hamdoun, A. M.; et al. Activation of ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
5 1. Teuber, M. (1995) The genus Lactococcus, in The Lactic Acid Bacteria (Wood, B. J. B. and Holzapfel, W. H., Eds.) 1 ed., pp 173-234, Blackie Academic and Professional,
 

Summary:  , 587-593. 11. Paulsen, I. T., Brown, M. H., and Skurray, R. A. (1996) Proton-dependent multidrug efflux... -deficient Streptococcus pneumoniae strain panel to identify ABC-class multidrug transporters involved in intrinsic... . and Nikaido, H. (2003) 3D structure of AcrB: the archetypal ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
6 LmrCD is a major MDR transporter in Lactococcus lactis
 

Summary:  and characterization of an ABC multidrug efflux pump, VcaM, in Non- O1 Vibrio cholerae. Antimicrob Agents Chemother 47... ,E.W., Huda,M.N., Kuroda,T., Mizushima,T., and Tsuchiya,T. 2003b. EfrAB, an ABC multidrug efflux pump... in multidrug ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
7 Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus)
 

Summary:  . These multidrug (mdr) efflux transporters are members of the ATP Binding Cassette (ABC) super-family and actively... Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos... functional and molecular evidence for acquisition of ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
8 Efflux Pump, the Masked Side of -Lactam Resistance in Klebsiella pneumoniae Clinical Isolates
 

Summary:  [25]. In addition, the functional rotation mechanism evidenced for the multidrug efflux pump AcrB may... - lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nococomial outbreak. J... , Nordmann P, Page`s J-M (2004) Detection and prevalence of active drug ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
9 THEORETICAL STUDY ON SOME -LACTAMS AS SUBSTRATES OF THE BACTERIAL MULTIDRUG RESISTANCE ACRB PUMP
 

Summary:  B pump is a part of the most important multidrug efflux system of gram-negative bacteria, which excretes... THEORETICAL STUDY ON SOME -LACTAMS AS SUBSTRATES OF THE BACTERIAL MULTIDRUG RESISTANCE ACRB PUMP... (penicillins and cephalosporins) and their efflux rates (minimal inhibitor concentrations, MICs) caused

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
10 Published: July 19, 2011 r 2011 American Chemical Society 6132 dx.doi.org/10.1021/ac201690t |Anal. Chem. 2011, 83, 61326134
 

Summary:  , Ontario M3J 1P3, Canada bS Supporting Information Multidrug resistance (MDR) due to active drug efflux... -associated drug efflux is driven by a superfamily of ATP-binding cassette (ABC) plasma membrane transporters.2... : June 30, 2011 Accepted: July 19, 2011 ABSTRACT: Multidrug ...

  

Source: Krylov, Sergey - Department of Chemistry, York University (Toronto)

 

Collection: Biology and Medicine ; Chemistry

 
11 Conjugating Berberine to a Multidrug Resistance Pump Inhibitor Creates an
 

Summary:  Staphylococcus aureus plasmid encod- ing a multidrug efflux system, J. Bacteriol. 180, 3477­3479. 15. Gros, P... of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: Novel agents for combina- tion... . E. (2002) The multidrug efflux pump NorA ...

  

Source: Ausubel, Frederick M. - Department of Genetics, Harvard University

 

Collection: Biology and Medicine

 
12 Multidrug Efflux Transporters Limit Accumulation of Inorganic, but Not
 

Summary:  Multidrug Efflux Transporters Limit Accumulation of Inorganic, but Not Organic, Mercury in Sea... we examined the role of multidrug efflux transport in the differential accumulation of inorganic (Hg... typesofATP-BindingCassette(ABC)effluxtransporters(7-9), the ABCB/p-glycoprotein (P-gp) ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
13 General introduction General introduction
 

Summary:  to be resistant to several chemically unrelated drugs is termed the multidrug resistance (MDR) phenomenon... -emergence of the multidrug resistant tuberculosis bacterial strain (MDR-TB) which emphasizes the need for a new strategy... to the emergence of a new strain known as VRSA (vancomycin resistant S. aureus) (1). Molecular studies on ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
14 [CANCER RESEARCH 61, 66356639, September 15, 2001] Advances in Brief
 

Summary:  /BCRP/ABCP-overexpressing cells studied; all demonstrated mitox- antrone transport, whereas only two effluxed rhodamine 123. When... were able to efflux rhodamine 123, whereas cells having an arginine were not. A vaccinia virus... expression system confirmed that rhodamine as well as doxorubicin efflux is observed with R482T or ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
15 ABC transporters ABC transporter architecture and regulatory roles of
 

Summary:  (CFTR/ABCC7), an ABC-type chloride channel, and multidrug- resistance conferred to tumor cells by P... (van der Heide and Poolman, 2002). Architecture of ABC efflux systems In contrast to ABC uptake systems... , which are present in the cytoplasmic membrane of prokaryotic species ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
16 Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1
 

Summary:  efflux and ABC transporter inhibitors. As is seen in planta, AtPGP1 also appears to mediate some efflux... auxin specificity to PGP-mediated transport. Keywords: auxin, P-glycoprotein, multi-drug resistance, ABC... -mediated efflux is sensitive to auxin ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
17 Introduction to multidrug transporters, cellular resistance and lantibiotic production in Lactococcus lactis
 

Summary:  by expressing them in a drug sensitive E. coli strain (13). This strain lacks the major multidrug efflux system... AB operon, this major multidrug efflux system was shown to confer resistance to 19 of the 24 compounds... expressed at non- physiologically high levels. This apparent opportunistic ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
18 Develop. Growth Differ. (2006) 48, 559573 doi: 10.1111/j.1440-169x.2006.00893.x Blackwell Publishing Asia
 

Summary:  is similar to the multidrug resistance (MDR) activity mediated by ATP binding cassette (ABC) efflux... efflux transporters include the permeability glycoproteins (P-gp) and multidrug resistance associated... with protein translation. Determination of the type(s) of ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
19 Introduction General introduction
 

Summary:  -energy by ATP hydrolysis. Figure 4. Schematic representation of (1) secondary multidrug transporter and (2) ABC... -type multidrug transporters. #12;Chapter 1 22 ATP-dependent multidrug transporters ABC multidrug transporters... A and LmrB of L. lactis are so far the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
20 Applied Mathematics Letters 24 (2011) 12511256 Contents lists available at ScienceDirect
 

Summary:  to trigger the induction of ATP-Binding Cassette (ABC) transporters, responsible for the efflux of the drug... ]. The enhancement of ABC transporter expression in Abbreviations: MDR, Multidrug resistance; ABC transporter, ATP... the following model for mRNA and protein amounts of ...

  

Source: Clairambault, Jean - Biologie, Analyse Numérique, Géophysique Team, INRIA Paris-Rocquencourt

 

Collection: Biology and Medicine


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21 doi:10.1006/scdb.2001.0250, available online at http://www.idealibrary.com on seminars in CELL & DEVELOPMENTAL BIOLOGY, Vol. 0, 2001: pp. 110
 

Summary:  human cancers. Key words: ABC superfamily / chemotherapy / P-glyco- protein / multidrug resistance... of the ABC domains of one half of the transporter is coupled to drug efflux, operating similarly to a two... of mammalian P-glycoproteins involved in multidrug resistance Christine A. ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
22 Drug efflux mechanism by a secondary transporter LmrP
 

Summary:  Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport... Drug efflux mechanism by a secondary transporter LmrP of Lactococcus lactis #12;Rodzicom Cover... Partners Ipskamp, Enschede #12;Rijksuniversiteit Groningen Drug efflux mechanism by a secondary transporter Lmr

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
23 Candida Drug Resistance Protein 1, a Major Multidrug ATP Binding Cassette Transporter of Candida albicans, Translocates Fluorescent Phospholipids in a
 

Summary:  and efflux drugs. We note that only a few members of the ABC superfamily of Candida have a well-defined role... . Overexpression of the multidrug transporter Cdr1p (Can- dida drug resistance protein 1), a member of the ABC1... : Characterization of CDR2, a new multidrug ...

  

Source: Menon, Anant K. - Menon Lab, Weill Medical College, Cornell University

 

Collection: Biology and Medicine

 
24 Annu. Rev. Pharmacol. Toxicol. 1999. 39:36198 BIOCHEMICAL, CELLULAR,
 

Summary:  -dependent multidrug efflux pump, known as the multidrug transporter, or P-glycoprotein (P-gp). P-gp was first detected... OF THE MULTIDRUG TRANSPORTER1 Suresh V. Ambudkar, Saibal Dey, Christine A. Hrycyna, Muralidhara Ramachandra,+,2 Ira... .ramachandra@canjii.com; pasta@helix.nih.gov; and mgottesman@nih.gov ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
25 Sociedade Brasileira de Qumica ( SBQ) Reunio Anual da Sociedade Brasileira de Qumica
 

Summary:  Chemometric and QSAR prediction of the multidrug resistance of VmrA efflux pump from Vibrio parahaemolyticus... , multidrug resistance Introduction Multidrug resistance (MDR) of microbes and parasites as well as of cancer... and parasitic diseases and cancer, respectively. Among major mechanisms of ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
26 Hop Resistance in the Beer Spoilage Bacterium Lactobacillus brevis Is Mediated by the ATP-Binding
 

Summary:  HorA protein identified HorA as a new member of the ABC family of multidrug transporters. #12;CHAPTER... bacterial multidrug resistance proteins, LmrA is an ATP-binding cassette (ABC) transporter (Higgins, 1992... of the ABC multidrug transporter LmrA in L. lactis ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
27 Copyright 2004 by the American Society for Biochemistry and Molecular Biology, Inc. 1256 Journal of Lipid Research Volume 45, 2004 This article is available online at http://www.jlr.org
 

Summary:  - tive lipid uptake of cholesteryl esters from lipid-rich HDL to cells and the efflux of unesterified... cholesterol from cells to HDL. ABCA1 mediates the efflux of unesterified choles- terol and phospholipids from... -naphthalen-2-yl- urea] (BLT-4), blocked ABCA1-mediated cholesterol efflux to lipid-poor apoA-I at a potency

  

Source: Kirchhausen, Tomas - Immune Disease Institute & Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
28 Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport of lipophilic cationic
 

Summary:  Chapter 2 Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles... SUMMARY The proton motive force-driven efflux pump LmrP confers multidrug resistance on Lactococcus lactis... residues involved in multidrug recognition aureus. These closely related ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
29 The crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmR
 

Summary:  that overexpress multidrug efflux pumps such as the prominent drug-proton antiporter, MexAB-OprM. The primary... multidrug efflux pumps confer widespread antibi- otic resistance by actively purging their cells... mechanism responsible for derepressing production of MexAB­OprM, the major ...

  

Source: McIntosh, Lawrence P. - Department of Biochemistry and Molecular Biology, University of British Columbia

 

Collection: Biotechnology ; Biology and Medicine

 
30 LmrR is a transcriptional repressor of the expression of the Multidrug ABC transporter LmrCD in
 

Summary:  Chapter LmrR is a transcriptional repressor of the expression of the Multidrug ABC transporter Lmr... in Lactococcus lactis 62 SUMMARY LmrCD is an ABC-type multidrug transporter of Lactococcus lactis. LmrR encodes... ,22). The overexpression of multidrug efflux pump(s) ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
31 Function of prokaryotic and eukaryotic ABC proteins in lipid transport Antje Pohla,b
 

Summary:  to the occurrence of multidrug resistant strains. Specific attention will be given here to ABC proteins found... of Leishmania [163]. LtrABC1.1 expres- sion appears to be uncorrelated with multidrug resistance... Review Function of prokaryotic and eukaryotic ABC proteins in lipid ...

  

Source: Institut de Biologie Physico-Chimique CNRS, Physico-Chimie Moléculaire des Membranes Biologiques

 

Collection: Chemistry ; Biology and Medicine

 
32 Sociedade Brasileira de Qumica ( SBQ ) Reunio Anual da Sociedade Brasileira de Qumica
 

Summary:  Quantitative Drug Structure ­ Complex Geometry Relationships in - Lactam Efflux by Bacterial Multidrug... descriptors, drug ­ pump geometry descriptors, molecular graphics Introdução Multidrug Resistance (MDR... people. One of the most frequent MDR mechanisms is the drug efflux from bacteria cells by ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
33 Regulation of multidrug resistance in Lactococcus Herfita Agustiandari
 

Summary:  ., Driessen, A. J. M. 2008. The ABC-type multidrug resistance transporter LmrCD is responsible... R is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis. J. Bacteriol... of the Multidrug ABC transporter LmrCD in ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
34 Bock et al. 2006 Family Summary 1.A.1 Voltage-gated Ion ChannVIC 36 34 2
 

Summary:  17 putative MATE-related efflux carrier DTX 51 46 694 2.A.66 Multidrug/Oligosaccharidy MATE 365... putative MATE-related efflux carrier DTX 2 2 745 2.A.66 Multidrug/Oligosaccharidy MATE 513 putative MATE... 107 93 957 3.A.1.201 Multidrug Resistance ExpoABC 102 ...

  

Source: Sze, Heven - Department of Cell Biology and Molecular Genetics, University of Maryland at College Park

 

Collection: Biology and Medicine

 
35 Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized CellsS
 

Summary:  ) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev... in their basolateral membrane and the recombinant ATP-driven efflux pump ABCC2 in their apical membrane. These double... on filter membranes and efflux experiments in cells preloaded with BSP were ...

  

Source: Timmer, Jens - Freiburger Zentrum für Datenanalyse und Modellbildung & Physikalisches Institut, Albert-Ludwigs-Universität Freiburg

 

Collection: Physics

 
36 Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized CellsS
 

Summary:  ) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev... in their basolateral membrane and the recombinant ATP-driven efflux pump ABCC2 in their apical membrane. These double... on filter membranes and efflux experiments in cells preloaded with BSP were ...

  

Source: Timmer, Jens - Freiburger Zentrum für Datenanalyse und Modellbildung & Physikalisches Institut, Albert-Ludwigs-Universität Freiburg

 

Collection: Physics

 
37 PharmGKB Submission Update: IV. PMT Submissions of Genetic Variations in ATP-
 

Summary:  IDs. Pharmacogenetic Significance: Genetic variation in the ATP-binding cassette (ABC) family... of efflux trans- porters may result in altered expression and/or function of the encoded proteins. Resulting... . Pharmacological Significance: ABC transporters are expressed in the basolateral (blood-facing) or api- cal (lumen

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
38 Lipid rafts : dream or reality for cholesterol transporters ? Stphane ORLOWSKI1
 

Summary:  remain to be clarified. Keywords: lipid rafts, cholesterol transport, ABC proteins, SR-BI, NPC1L1... , intestinal absorption. Abbreviations: ABC: ATP-binding cassette; ACAT: acyl-coenzyme A... : low density lipoprotein; LXR: liver X receptor ; (M)CD: (methyl)-cyclodextrin; MDR: multidrug

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
39 Genome Biology 2004, 5:R15 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation
 

Summary:  with multidrug resistance (MDR). Decottignies and Goffeau [6] catalogued the entire ABC transporter family... commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation Open Access2004Shepset al.Volume 5, Issue 3, Article R15Research The ABC transporter gene family... of Caenorhabditis elegans has implications ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
40 Multidrug and peptide export in Lactococcus lactis
 

Summary:  Multidrug and peptide export in Lactococcus lactis Bart van den Berg van Saparoea 2009 #12;The work... ;RIJKSUNIVERSITEIT GRONINGEN Multidrug and peptide export in Lactococcus lactis Proefschrift ter verkrijging van het... in Lactococcus lactis 7 Chapter 2 Heterologously expressed bacterial and human multidrug resistance proteins

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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41 Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric Dimers
 

Summary:  of the ATP binding cassette (ABC) transporter superfamily, is overexpressed in numerous multidrug... Oligomerization of the Human ABC Transporter ABCG2: Evaluation of the Native Protein and Chimeric... . Human ABCG2, also known as MXR/BCRP/ABCP, is a member of the ATP binding cassette (ABC)1 transporter

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
42 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  -binding cassette efflux transporters at the blood-brain barrier are P-glycoprotein (P-gp), multidrug resistance... -gp. Efflux transporters of the ATP-binding cassette (ABC) family block the entry into cells of many diverse... -brain barrier, the three most prevalent ABC transporters are ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
43 N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the
 

Summary:  -binding cassette efflux transporters at the blood-brain barrier are P-glycoprotein (P-gp), multidrug resistance... -gp. Efflux transporters of the ATP-binding cassette (ABC) family block the entry into cells of many diverse... -brain barrier, the three most prevalent ABC transporters are ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
44 Short communication The sea urchin embryo as a model for studying
 

Summary:  analysis of calcein and calcein- acetoxymethylester efflux mediated by the multidrug resistance protein... .R., Epel, D., 2004. Activation of multidrug efflux transporter activity at fertilization in sea urchin... Short communication The sea urchin embryo as a model for studying efflux ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
45 QSAR Study of -Lactam Antibiotic Efflux by the Bacterial Multidrug Resistance Pump AcrB Mrcia Miguel Castro Ferreira (PQ) and Rudolf Kiralj (PQ)
 

Summary:  QSAR Study of -Lactam Antibiotic Efflux by the Bacterial Multidrug Resistance Pump AcrB Márcia... antibiotics (penicillins and cephalosporins) as substrates of multidrug resistance efflux membrane pump Acr... M. M. C., Kiralj R., "QSAR study of -lactam antibiotic efflux by the bacterial ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
46 Distinct mechanisms of LmrR mediated gene regulation of multidrug resistance
 

Summary:  from Listeria monocytogenes, negatively regulates the expression of the multidrug efflux pump Mdr... . Neyfakh,A.A., Bidnenko,V.E., and Chen,L.B. 1991. Efflux-mediated multidrug resistance in Bacillus subtilis... is a multidrug efflux transporter. Antimicrob Agents ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
47 Functional hot spots in human ATP-binding cassette transporter
 

Summary:  review implicated 12 ABC transporters from four families in in vitro multidrug resistance in tissue... , and the TMD of the structure of the Staphylococcus aureus multidrug ABC transporter Sav1866 in light blue... in Human ABC Transporters #12;transfection of HEK293T cells.29 Here, we ...

  

Source: Sali, Andrej - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine ; Biotechnology

 
48 Sociedade Brasileira de Qumica SBQ Reunio Anual da Sociedade Brasileira de Qumica -SBQ -26 a 29 de Maio de 2003
 

Summary:  as Substrates of the Multidrug Resistance Efflux AcrB Pump Rudolf Kiralj (PQ), Márcia Miguel Castro Ferreira (PQ... , Brasil Palavras Chave: multidrug resistance efflux, AcrB bacterial pump, chemometrics Introdução Acr... AB-TolC is the most important multidrug resistance ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
49 UNIVERSIT PARIS XI FACULT DE PHARMACIE DE CHTENAY-MALABRY
 

Summary:  récapitulatif de l'effet des antirétroviraux sur l'efflux médié par les transporteurs ABC Tableau 10 : Tableau... THÉRAPIES ANTI-VIH : Rôle des transporteurs d'efflux sur le passage transmembranaire des antirétroviraux au... transporteurs ABC 63 CHAPITRE 3 : Les transporteurs ABC ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
50 Aquatic Toxicology 61 (2002) 127140 www.elsevier.com/locate/aquatox Tolerance to biodegraded crude oil in marine invertebrate
 

Summary:  as multidrug resistance, MDR). This mechanism is primarily mediated by ATP-dependent, efflux pumps that extrude... to express MXR efflux protein nor MXR mediated dye efflux capacity. In contrast, BWSF acts as a competitive... inhibitor of MXR transport-mediated dye efflux in Urechis ...

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
51 Mutation Research 552 (2004) 101117 Emerging contaminants--pesticides, PPCPs, microbial
 

Summary:  and toxic effects of other xenobiotics normally effluxed by MXRtransportproteins... as a "first line of defense" [2] against endogenous and exogenous toxicants. MXR results from the rapid efflux... which can act as specific inhibitors. These chemicals have the potential to block this active efflux

  

Source: 

 

Collection: Environmental Sciences and Ecology

 
52 Summary and concluding remarks Summary and concluding remarks
 

Summary:  for the intrinsic multidrug resistance in L. lactis. These are ABC half-transporter that heterodimerize to form... . The transmembrane domains of the ABC multidrug transporter LmrA form a cytoplasmic exposed, aqueous chamber within... Chapter Summary and concluding remarks #12;Summary and concluding remarks ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
53 Bivalent Probes of the Human Multidrug Transporter P-Glycoprotein Marcos M. Pires, Christine A. Hrycyna,* and Jean Chmielewski*
 

Summary:  ) Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview, AdV. Drug Deli... Bivalent Probes of the Human Multidrug Transporter P-Glycoprotein Marcos M. Pires, Christine A... library of bivalent agents was designed to probe the substrate binding sites of the human multidrug

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
54 Reference list Ainsa, J. A., Blokpoel, M. C., Otal, I., Young, D. B., De Smet, K. A. and Martin, C. (1998). Molecular cloning and
 

Summary:  , a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis. J... , M. H., Jr. (2000). A broad-specificity multidrug efflux pump requiring a pair of homologous SMR... multidrug efflux system of Pseudomonas aeruginosa. ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
55 Molecular Biology of the Cell Vol. 7, 1485-1498, October 1996
 

Summary:  -stimulated ATPase activity, efflux of rhodamine 123, and accumulation of radiolabeled vinblastine and colchicine... . No differences were seen in verapamil-inhibited rhodamine 123 efflux, but the rate of accumulation was slower... man multidrug resistance (MDR1) gene (Gottesman Research. © 1996 by The American Society for Cell

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
56 Summary and concluding remarks Introduction
 

Summary:  (ABC) transporters MsbA, a lipid efflux system that was crystallized in three conformations... . coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science 293, 1793... -1800. Chang, G. (2003) Structure of MsbA from Vibrio cholera: a multidrug resistance ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
57 QSAR study of structurally unrelated substrates of MDR efflux pump VmrA from V. parahaemolyticus Rudolf Kiralj and Mrcia Miguel Castro Ferreira. marcia@iqm.unicamp.br, rudolf@iqm.unicamp.br, http://lqta.iqm.unicamp.br
 

Summary:  of the Na+/multidrug transporter VmrA and VmrA- mediated drug efflux from the cytoplasm to periplasm... , ITS MULTIDRUG RESISTANCE (MDR) EFFLUX MECHANISM, AND ITS SUBSTRATES The HCA dendograms with samples... QSAR study of structurally unrelated substrates of MDR efflux pump VmrA from V. ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
58 10.1110/ps.051998406Access the most recent version at doi: 2006 15: 1597-1607Protein Sci.
 

Summary:  , G. 2003. Structure of MsbA from Vibrio cholera: A multidrug resistance ABC transporter homolog... . coli: A homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science 293: 1793... transporter-mediated multidrug efflux. FEBS Lett. 580: ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
59 JOURNAL OF BACTERIOLOGY, Aug. 2007, p. 54415451 Vol. 189, No. 15 0021-9193/07/$08.00 0 doi:10.1128/JB.00543-07
 

Summary:  Modulator of Multidrug Efflux Gene Expression in Pseudomonas aeruginosa Denis M. Daigle,2 Lily Cao,1... enhanced expression of the mexAB-oprM multidrug efflux system as a direct result of the production of a ca... with MexR. Multidrug efflux systems of the ...

  

Source: Strynadka, Natalie - Department of Biochemistry and Molecular Biology, University of British Columbia

 

Collection: Biology and Medicine

 
60 Discussion and concluding remarks General introduction
 

Summary:  cellular components modulate the activity of OpuA and other ABC transporters, and thereby cause efflux... transporters are the low-resolution structures of the human multi-drug resistance (MDR) ABC transporters P... -permeable lipid membrane, only permeable to water and small hydrophobic molecules, water ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology


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61 Summary and concluding ESEARCH on the structure and function of substrate-binding proteins (SBPs)
 

Summary:  (Hvorup et al., 2007; Kadaba et al., 2008). Information on ABC-type efflux systems has become available... , and have diverse functions. Many, like Sav1866 and P-gp are involved in multi-drug extrusion. ABC importers... -binding proteins (SBPs) of ATP Binding Cassette (ABC) transporters ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
62 The Rockefeller University Press, 0021-9525/98/11/645/13 $2.00 The Journal of Cell Biology, Volume 143, Number 3, November 2, 1998 645657
 

Summary:  to activate ATP efflux (wtCFTR, Cl Br; R347P, Cl Br; R347E, Br Cl; R334W, Cl Br). We hypothesize that residues... for activation of ATP efflux in re- sponse to increases of extracellular Cl . In summary, these findings suggest... chloride concentration by modulating the activity of an unidentified ATP efflux pathway. This ...

  

Source: Engelhardt, John F. - Department of Anatomy and Cell Biology, University of Iowa

 

Collection: Biology and Medicine

 
63 368 VOLUME 86 NUMBER 4 | OCTOBER 2009 | www.nature.com/cpt STATE ART nature publishing group
 

Summary:  to image the function of the ABC trans- porter ABCC1 (multidrug-resistance protein, or MRP1) in wild... Transporters belonging to the adenosine triphosphate (ATP)- binding cassette (ABC) superfamily maintain... of concentration gradient. The ABC transporters are encoded by 48 genes in the human genome and ...

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
64 The role of multixenobiotic transporters in predatory marine molluscs as counter-defense mechanisms against dietary allelochemicals
 

Summary:  -gp and multidrug resistance-associated protein (MRP) families of ABC transporters in T. hamnerorum. In addition, we... Available online 21 May 2010 Keywords: ABC transporter Allelochemical Calcein-AM Gorgonian MK571 MRP P... and molecular evidence for multixenobiotic transporter-mediated efflux activity and ...

  

Source: Sotka, Erik - Grice Marine Laboratory, College of Charleston

 

Collection: Environmental Sciences and Ecology

 
65 Drug efflux mechanism by a secondary transporter LmrP
 

Summary:  Acidic residues in the lactococcal multidrug efflux pump LmrP play critical roles in transport... Drug efflux mechanism by a secondary transporter LmrP of Lactococcus lactis #12;Rodzicom Cover... Partners Ipskamp, Enschede #12;Rijksuniversiteit Groningen Drug efflux mechanism by a secondary transporter Lmr

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
66 Multidrug and peptide export in Lactococcus lactis
 

Summary:  by expressing them in a drug sensitive E. coli strain (13). This strain lacks the major multidrug efflux system... AB operon, this major multidrug efflux system was shown to confer resistance to 19 of the 24 compounds... expressed at non- physiologically high levels. This apparent opportunistic ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
67 AnmtRev, Genct.1995, 29:607-49 Copyright1995by AnnualReviewsInc. All rights reserved
 

Summary:  as the multidrug transporter, or P-glycoprotein (P-gp), which blocks uptake and in- creases efflux of natural... ATP-dependent plasmamembranetransport system,knownas P-glyeoprotein,or the multidrug transporter... ................... 608 Identification and Characterization of the Multidrug Transporter ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
68 Structure of the transcriptional regulator LmrR and its mechanism of multi-drug recognition
 

Summary:  R-related transcriptional repressor that regulates the production of LmrCD, a major multidrug ABC transporter in Lactococcus... of the heterodimeric ABC transporter LmrCD, which is a major multidrug transporter in Lactococcus lactis (22... structure of a transcription factor regulating the expression of a ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
69 Published on Web Date: October 21, 2010 r 2010 American Chemical Society 82 DOI: 10.1021/cn100078a |ACS Chem. Neurosci. (2011), 2, 8289
 

Summary:  (MRP1 inhibitor). Table 1. Effect of Tariquidar on the Cytotoxicity of Drugs Effluxed by Three ABC... of the multidrug resistance-linked ABC drug transporter, ABCG2. Biochemistry 45, 8940­8951. 33. Ambudkar, S. V... , Bethesda, Maryland, United States Abstract Tariquidar was developed as a specific inhibitor ...

  

Source: Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
70 Abstract Incubation of PC12 cells with the sulfonylurea drug, glipizide (1100 M), increased intracellular levels
 

Summary:  efflux from PC12 cells. Both CFTR and the ABC1 protein are blocked by the sulfonylureas (Sheppard... confers multidrug resistance as- sociated with increased drug efflux and altered intracellular drug... or by tetrodotoxin and blocked by drugs that interact with the multidrug-resistance ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
71 N d'ordre : 270-2007 Anne 2007 prsente devant
 

Summary:  ........................................................ 17 2. Les transporteurs ABC chez l... ............................................................................................. 36 3.2. Evolution de la branche « C » de la superfamille ABC... .10.2. Fonctionnement coopératif des NBD des protéines ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
72 Transmembrane Inhibitors of P-Glycoprotein, an ABC Transporter Nadya I. Tarasova,*, Rishi Seth, Sergey G. Tarasov, Teresa Kosakowska-Cholody, Christine A. Hrycyna,#,
 

Summary:  . H. Reversing agents for ATP-binding cassette (ABC) transporters: application in modulating multidrug... . Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) trans... Transmembrane Inhibitors of P-Glycoprotein, an ABC Transporter Nadya I. ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
73 Effect of the calcium channel blocker verapamil on drug-extrusion and resistance mediated by the
 

Summary:  mediated by the multidrug resistance protein LmrP of Lactococcus lactis H. Bart van den Berg van Saparoea... the transport of the fluorescent model substrates Hoechst 33342 and ethidium by the lactococcal multidrug... is an unreliable diagnostic tool to study multidrug resistance transporters in vivo. #12;52 Introduction Lmr

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
74 UNIVERSITE PARIS DESCARTES FACULTE DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES
 

Summary:  antibiotiques MDR (multidrug-resistance ; Poole, 2004). Les pompes d'efflux sont des transporteurs actifs. Il... superfamilly ; SMR-small multidrug resistance ; MATE-multidrug and toxic compound extrusion ; ABC-atp binding... transmembranaire Domaine ABC Monomère ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
75 OAK RIDGE NATIONAL LABORATORY U. S. DEPARTMENT OF ENERGY
 

Summary:  and heavy metal efflux pumps, proteins involved in osmotic adaptation, sulfate ABC transporters... to be hypersensitive to SrCl2 exposure, compared to parental and wild-type strains. Transcripts encoding multidrug

  

Source: Oak Ridge National Laboratory Fossil Energy Program

 

Collection: Fossil Fuels

 
76 The Elementary Mass Action Rate Constants of P-gp Transport for a Confluent Monolayer of MDCKII-hMDR1 Cells
 

Summary:  parameters show how P-gp efflux of a wide range of xenobiotics has been maximized. INTRODUCTION Multi-drug... ABSTRACT The human multi-drug resistance membrane transporter, P-glycoprotein, or P-gp, has been... monolayer, drug dissociation back into the apical membrane inner monolayer, and drug efflux from P

  

Source: Mittal, Aditya - School of Biological Sciences, Indian Institute of Technology, Delhi

 

Collection: Biotechnology ; Biology and Medicine

 
77 Dynamical Determinants of Drug-Inducible Gene Expression in a Single Bacterium
 

Summary:  to environmental signals. Here, we investigate how multidrug efflux pump systems mediate the dynamics of a simple... of the acrAB-TolC multidrug efflux pump system. When cells are exposed to constant level... emerging from the dependence of drug-inducible transcription on multidrug ...

  

Source: Cluzel, Philippe - Department of Molecular and Cellular Biology, Harvard University; Emonet, Thierry - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Biology and Medicine ; Physics

 
78 Heavy Metal Tolerance in Stenotrophomonas maltophilia Delphine Pages1,2,3
 

Summary:  ], and expression of efflux pumps. Two RND efflux systems have been identified, SmeABC [13] and SmeDEF [14... membrane multidrug efflux protein of Stenotrophomonas maltophilia. Antimicrob Agents Chemother 46: 333... ­43. 14. Alonso A, Martinez JL (2000) Cloning and characterization of ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
79 Structure and Dynamics of Large Biological Molecules: ATP-Binding Cassette (ABC) Transporters
 

Summary:  -glycoprotein) contribute to multidrug resistance of cancer cells, and ABC proteins are also associated with cystic fibrosis... helices. Selective uptake and efflux by ABC transporters is driven against concentration gradi- ents using... . Dawson and K. P. Locher, Structure of a bacterial ...

  

Source: Jones, R. O.- Institut für Festkörperforschung, Forschungszentrum Jülich

 

Collection: Materials Science

 
80 Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A
 

Summary:  ABSTRACT Several ATP-binding cassette (ABC) transporters can confer multidrug resistance to cancer cells... by functioning as energy- dependent efflux pumps. The half-transporter ABCG2 and the widely studied P... -glycoprotein (P-gp) are two ABC transporters that, when overexpressed, are capable of extruding ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry


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81 General introduction I. General features of cell volume control
 

Summary:  .g. the multiple-drug resistance (MDR) transporters. Well-studied ABC-type efflux systems are the human multidrug... in the millimolar range. It cannot be excluded, however, that osmoregulated ABC transporters facilitate efflux... the whole ABC-superfamily. In this ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
82 European Journal of Pharmaceutical Sciences 37 (2009) 106114 Contents lists available at ScienceDirect
 

Summary:  kinetics Efflux mechanisms Non-linear absorption Three-compartment model Michaelis­Menten a b s t r a c... . The results were applied to an absorption experiment with multidrug transporter-affected antibiotic CNV97100... mathematical model with efflux pump indicated on apical side (right). substance should have low lipophilicity

  

Source: Toral, Raúl - Mediterranean Institute for Advanced Studies & Departament de Física, Universitat de les Illes Balears

 

Collection: Materials Science ; Physics

 
83 JOURNAL OF BACTERIOLOGY, Nov. 2002, p. 62256234 Vol. 184, No. 22 0021-9193/02/$04.00 0 DOI: 10.1128/JB.184.22.62256234.2002
 

Summary:  37 EvgA-activated genes, including acid resistance-related genes gadABC and hdeAB, efflux pump genes... survival rates com- parable to that of MG1655. Identification of the efflux pump responsible for multidrug... ). To identify the efflux pump(s) responsible for the ...

  

Source: Church, George M. - Wyss Institute for Biologically Inspired Engineering & Department of Genetics, Harvard University

 

Collection: Biotechnology

 
84 Energetics of wild-type and mutant multidrug resistance secondary transporter LmrP of Lactococcus lactis
 

Summary:  membrane. Besides the specific drug efflux systems (SDRs), multidrug resistance (MDR) transporters... Chapter 4 Energetics of wild-type and mutant multidrug resistance secondary transporter Lmr... P of Lactococcus lactis Piotr Mazurkiewicz, Arnold J.M. Driessen and Wil N. Konings SUMMARY LmrP, a ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
85 Pour obtenir le grade de DOCTEUR DE L'UNIVERSIT DE GRENOBLE
 

Summary:  to chemotherapeutic agents (Multidrug Resistance or MDR) is characterized by the overexpression of membrane ABC... ) membranaires, membres de la superfamille des transporteurs ABC et notamment les transporteurs MRP1 (Multidrug... Fonction ABCA1 ABC1 9q31.1 Nombreux tissus ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
86 What do the proton motive force-driven multidrug resistance transporters have in common?
 

Summary:  Chapter 1 What do the proton motive force-driven multidrug resistance transporters have in common... sequencing projects in recent years has demonstrated that multidrug resistance (MDR) transporters are widely... of multidrug recognition and the transport mechanisms will allow a more rational design of new drugs which

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
87 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, July 2008, p. 26162625 Vol. 52, No. 7 0066-4804/08/$08.00 0 doi:10.1128/AAC.01643-07
 

Summary:  . Whole-Genome Pyrosequencing of an Epidemic Multidrug-Resistant Acinetobacter baumannii Strain Belonging... /Accepted 8 April 2008 The whole-genome sequence of an epidemic, multidrug-resistant Acinetobacter baumannii... is the main advantage of A. baumannii in the nosocomial environment (15). Multidrug- resistant clones of A

  

Source: Dever, Jennifer A. - Biology Department, University of San Francisco

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
88 ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 0066-4804/00/$04.00 0
 

Summary:  -Laslop, and A. A. Neyfakh. 1994. A protein that activates expression of a multidrug efflux transporter upon... -dependent multidrug efflux systems. Microbiol. Rev. 60:575­608. 12. Yanisch-Perron, C., J. Vieira, and J. Messing... Represses the Escherichia coli emrRAB Multidrug Resistance ...

  

Source: Matin, A.C. - Department of Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine ; Environmental Management and Restoration Technologies

 
89 Relationships between MDR proteins, bacteriocin production and proteolysis in Lactococcus lactis
 

Summary:  -energy by ATP hydrolysis. Figure 4. Schematic representation of (1) secondary multidrug transporter and (2) ABC... -type multidrug transporters. #12;Chapter 1 22 ATP-dependent multidrug transporters ABC multidrug transporters... A and LmrB of L. lactis are so far the ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
90 Copyright 2007 by the Genetics Society of America DOI: 10.1534/genetics.106.066720
 

Summary:  resistance. The PGP1 protein is a broad- spectrum multidrug efflux pump with the common ABC protein structure... Accepted for publication December 24, 2006 ABSTRACT ABC transporters constitute one of the largest gene... previously demonstrated that the Caenorhabditis elegans ABC family ...

  

Source: Baillie, David - Department of Molecular Biology and Biochemistry, Simon Fraser University

 

Collection: Biology and Medicine

 
91 Quantitative Drug Structure Complex Geometry Relationships in -Lactam Efflux by Bacterial Multidrug Resistance Pump AcrAB-TolC
 

Summary:  cavity of the multidrug efflux pump AcrB (a component of AcrAB-TolC membrane transporter) that exists... . BACTERIAL MULTIDRUG RESISTANCE VIA ACTIVE DRUG EFFLUX BY MEANS OF A PROTON-DEPENDENT AcrAB-TolC PUMP... Quantitative Drug Structure ­ Complex Geometry Relationships in -Lactam Efflux ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
92 Prediction of -lactam position and orientation in the central cavity of the component of bacterial AcrAB-TolC multidrug efflux pump AcrB
 

Summary:  AcrAB-TolC multidrug efflux pump AcrB Márcia Miguel Castro Ferreira and Rudolf Kiralj Laboratório de... -lactam antibiotics in the central cavity of the multidrug efflux pump AcrB (a component of Acr... Relationships. BACTERIAL MULTIDRUG RESISTANCE VIA ACTIVE DRUG ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
93 P-Glycoprotein Function at the BloodBrain Barrier in Humans Can Be Quantified with
 

Summary:  studied ABC transporters is ABCB1, which is the product of the multidrug resistance gene, more commonly... Center, National Institutes of Health, Bethesda, Maryland Permeability-glycoprotein (P-gp), an efflux... to estimate the rates of entry into (K1) and efflux from (k2) the brain. Results: Brain uptake

  

Source: Innis, Robert B. - Molecular Imaging Branch, National Institute of Mental Health; Pike, Victor W. - Molecular Imaging Branch, National Institute of Mental Health

 

Collection: Biology and Medicine

 
94 Extensive Chemometric Investigations of the Multidrug Resistance in Strains of the Phytopathogenic Fungus Penicillium Digitatum
 

Summary:  analyses. Genome descriptors for fungal cytochrome P450 sterol 14a-demethylase and multidrug efflux pump... such as cytochromes, efflux pumps, and regulatory proteins which activate fungal multidrug resistance. 1 Introduction... mediated by efflux pumps from the ATP-binding cassette ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry

 
95 N-Linked Glycosylation of the Human ABC Transporter ABCG2 on Asparagine 596 Is Not Essential for Expression, Transport Activity, or Trafficking to the
 

Summary:  into or out of cells (3). ABC transporters known to be involved in mammalian multidrug resistance are P... neither the drug transport function of ABC multidrug transporters, P-gp and MRP1, nor the substrate... . Ejendal, K. F., and Hrycyna, C. A. (2002) Multidrug resistance and cancer: ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
96 UNIVERSITE JOSEPH FOURIER -GRENOBLE I ECOLE DOCTORALE CHIMIE ET SCIENCES DU VIVANT
 

Summary:  'antibiotiques .................................................................................................................................42 4. Transporteurs ABC bactériens impliqués dans l'efflux de multiples drogues caractérisés au... Biologie Structurale et Nanobiologie Carmen GALIÁN BARRUECO Caractérisation de 2 transporteurs ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
97 4104-8--Templeton--Ch21--R1--07-24-03 16:17:03--Selectable Markers for Gene Therapy2
 

Summary:  dependent transporters (ABC transporters), including the 32 human multidrug resistance gene MDR1 (ABC B1) (3... ,5,6), 33 MRP1 (ABC C1), the multidrug resistance-associated protein 34 (7) and other MRP family members (8... ), and MXR (ABC G2) 35 (9). MDR1 encodes the ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
98 Substrate Overlap between Mrp4 and Abcg2/Bcrp Affects Purine Analogue Drug Cytotoxicity and Tissue Distribution
 

Summary:  was first attributed to the efflux capabilities of the ABC transporter Mrp4 (ABCC4; refs. 5, 18, 27, 28... , our results not only extend the list of ABC transporters that efflux purine analogues to include Abcg2... -binding cassette (ABC) transporter knockout (KO) animals may facilitate ...

  

Source: Hrycyna, Christine A. - Department of Chemistry, Purdue University

 

Collection: Biology and Medicine ; Chemistry

 
99 RESVERATROL IN HUMAN HEPATOMA HEPG2 CELLS: METABOLISM AND INDUCIBILITY OF DETOXIFYING ENZYMES
 

Summary:  inhibitor, strongly suggests the involvement of this ABC transporter family in the efflux of resveratrol... : sulfotransferase; MDR: multi-drug resistance; MRP: multi-drug resistance-associated protein; RT-PCR: reverse... and the efflux of resveratrol were studied in the human ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
100 Quantitative relationships between -lactam molecular properties and -lactam/AcrAB-TolC complex geometry as determinants of MDR efflux
 

Summary:  the position and orientation of 16 -lactam antibiotics in the central cavity of the multidrug efflux pump Acr... Relationships + Exploratory Analysis. THE AcrAB-TolC PUMP, ITS MULTIDRUG RESISTANCE (MDR) EFFLUX MECHANISM... geometry as determinants of MDR efflux Márcia Miguel Castro ...

  

Source: Ferreira, Márcia M. C. - Instituto de Química, Universidade Estadual de Campinas

 

Collection: Chemistry


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