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Sample search results for: a2b antagonist mediate

Page:   2  3  4  5 
 
1 Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists
 

Summary:  log b b2 a2 b b2 a2 . (7) tions of antagonist. Each current is the sum of 500 single channel traces... a minor semiaxis, a, and a major semiaxis, b, with surface area given by (Levy, 1995) Area 2 b2 a2 b b2 a2... , of such an object is given by ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
2 NMDA receptor subunits: function and pharmacology Pierre Paoletti and Jacques Neyton
 

Summary:  2A>>2B>2C 2D - partial antagonist >100-fold (maximal inhibition ~70%) - glutamate affinity - low... "efficacy" on NR1/2A/2B and NR1/2A/2C triheteromeric receptors 2B>>2A 2C 2D - partial antagonist ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
3 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 53:281291 (2001)
 

Summary:  -4), histamine (H1), serotonin (5-HT3) or adenosine (A1 and A2B) receptors [Lambrecht et al., 1992, 2000; Boyer... , a novel functionally selective antagonist of P2 purinoceptor- mediated responses. Eur J Pharmacol 217... can be altered at the pyridoxal and phenyl moieties to produce P2X1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
4 Vol. 275, No. 3 Printed in U.S.A.
 

Summary:  combi- nations of cloned rat NMDA receptors (NR1NNR2A, 2B, 2C or 2D) ranged from 0.4 to 8 M (1 M glycine... with either NR2A, 2B, 2C or 2D. Currents elicited by activation of cloned receptors were similar to those... .4, 5.1) 0.31 (2.8, 3.4) 3 3 5 3 NMDA receptor ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
5 GABAA and GABAB Antagonists Differentially Affect the Firing Pattern
 

Summary:  a pacemaker pattern (A2). B: After application of picrotoxin, both neurons show a marked switch to a bursty... by local application of bicuculline (A2, B2, C2). A1, B1: No significant correlation was found between pre... GABAA and GABAB ...

  

Source: Tepper, James M. - Center for Molecular and Behavioral Neuroscience, Rutgers University at Newark

 

Collection: Biology and Medicine

 
6 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  , A2B and A3, and, in 1985, Burnstock and Kennedy proposed a basis for distinguishing between two... of adenosine triphosphate, adenosine diphosphate, uridine triphosphate and adeno- sine. These molecules mediate... . The antithrombotic action of clopidogrel (Plavix), a P2Y12 receptor ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
7 Transient Plasticity of Hippocampal CA1 Neuron Glutamate Receptors Contributes to Benzodiazepine
 

Summary:  antagonists. Neurons were voltage-clamped from À80 to þ 40 mV in cSEVC. NMDAR-mediated EPSCs were elicited... M, perhaps sufficient to potentiate GABAR-mediated inhibition. Therefore, the effect of the BZ antagonist... receptor (AMPAR)-mediated and reduced NMDA receptor ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
8 Benzodiazepine-induced hippocampal CA1 neuron alph...[Behav Pharmacol. 2007] -PubMed Result Behav Pharmacol. 2007 Sep;18(5-6):447-60. Links
 

Summary:  AMPAR-mediated neuronal overexcitation. NMDAR antagonist administration (MK-801, 0.25 mg/ kg... was observed between increased AMPAR-mediated mEPSC amplitude and anxiety-like behavior in 1-day FZP... -withdrawn rats. These effects were disrupted by systemic AMPAR antagonist administration (GYKI-52466, 0.5 mg/ ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
9 Summary and conclusions Summary and conclusions
 

Summary:  as the development of specific receptor antagonists with serotonin reuptake inhibition (nefazodone, trazodone). More... interaction which can mediate antidepressant effects (glucocorticoids, corticotrophin releasing factor... of action. It is hoped that some of the data may lead to a better understanding of how SSRIs mediate

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
10 Rational discovery of novel nuclear hormone receptor antagonists
 

Summary:  light on the LBD structural changes mediated by NR antagonists (11, 12): ER agonists and antagonists... Rational discovery of novel nuclear hormone receptor antagonists Matthieu Schapira* , Bruce M... , with the exception of the human estrogen receptor- , the lack of antagonist-bound ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
11 NPY signaling through Y1 receptors modulates thalamic oscillations
 

Summary:  antagonists; Fig. 3A2, B2 and C2 show single oscillations under all experimental conditions. Results were... . Oscillations grow weaker over time and eventually stop (see traces in Figs. 2 and 3 A2, B2 and C2... of the three Y receptor agonists. ...

  

Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University

 

Collection: Biology and Medicine

 
12 doi: 10.1098/rstb.2005.1788 , 277-2853612006Phil. Trans. R. Soc. B
 

Summary:  coevolution Detecting sexual conflict and sexually antagonistic References http... antagonistic coevolution Locke Rowe1,2,* and Troy Day3,4 1 Department of Zoology, University of Toronto... conflict and resultant sexually antagonistic coevolution. We then use published empirical examples

  

Source: Rowe, Locke - Department of Ecology and Evolutionary Biology, University of Toronto

 

Collection: Environmental Sciences and Ecology

 
13 Novel Treatment for Stroke, Brain Trauma, Alzheimer's Disease and
 

Summary:  cell death, unlike previous non-specific NMDA receptor antagonists Principal Inventor(s): Dr. Yu Tian... Wang Publications/References: Liu Y, et al. NMDA receptor subunits have differential roles in mediating... damage following stroke or brain trauma is largely due to excitoxicity mediated by excessive release

  

Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia

 

Collection: Engineering

 
14 Detecting sexual conflict and sexually antagonistic coevolution
 

Summary:  Detecting sexual conflict and sexually antagonistic coevolution Locke Rowe1,2,* and Troy Day3,4 1... approaches for detecting interlocus sexual conflict and resultant sexually antagonistic coevolution. We... attributes emerge. First, the dynamics of sexually antagonistic coevolution may obscure the conflict itself

  

Source: Day, Troy - Departments of Mathematics and Statistics & Biology, Queen's University (Kingston)

 

Collection: Environmental Sciences and Ecology

 
15 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... pathophysiological roles of ATP, ADP, UTP and adenosine. These molecules mediate short-term (acute) signalling... receptor antagonist, has been shown to be particularly useful in the ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
16 The Novel Antipsychotic Drug Lurasidone Enhances NMDA Receptor-Mediated Synaptic Responses
 

Summary:  subunits remained similar in saline- vs. lurasidone-injected animals (total NR2A/2B/1: 0.9±0.2 fold... MOL #76141 The Novel Antipsychotic Drug Lurasidone Enhances NMDA Receptor- Mediated Synaptic... produced a significant and selective enhancement of NMDAR-mediated synaptic responses and ...

  

Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo

 

Collection: Biology and Medicine

 
17 BRIEF COMMUNICATION doi:10.1111/j.1558-5646.2010.01100.x
 

Summary:  are the frequencies of the A2B1 haplotype; and x4, y4 are the frequencies of the A2B2 haplotype. We assemble... and male parent, respectively. A1B1 A1B2 A2B1 ...

  

Source: Úbeda, Francisco - Department of Ecology and Evolutionary Biology, University of Tennessee

 

Collection: Biology and Medicine

 
18 Cellular/Molecular Calcium Increases in Retinal Glial Cells Evoked by Light-
 

Summary:  . In the presence of 2 M NECA, the A2B receptor antagonist MRS 1706 (1 M) reduced the light-evoked Mu¨ller cell... that adenosine potentiation of Mu¨ller cell Ca2 responses is mediated primarily by A2B receptors, in ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
19 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  depression A2A Brain, heart, lungs, spleen Facilitates neurotransmission; smooth muscle relaxation A2B Large... in neurotransmission and neuromodulation, with their effects being mediated by the purine and pyrimidine receptor... of methylxanthine antagonists21 . ADO also exerts central ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
20 Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking
 

Summary:  of Antagonist 1-850 and Derivatives on the T3-Mediated Binding of TR to the Coactivator NRC in Vitro. Full... by using a PhosphorImager. The results shown in Fig. 5 indicate that the antagonists block the T3-mediated... Discovery of diverse thyroid hormone receptor antagonists by ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine


Page:   2  3  4  5 
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21 Nonpeptide antagonists of neuropeptide receptors: Tools for research and therapy
 

Summary:  antagonists interfere only with the actions of angiotensin II mediated by AT1 receptors. This might result... receptor mediated dopamine release from rat striatum6 . Both SR48968 and another NK2 antagonist, GR159897... Nonpeptide antagonists of neuropeptide receptors: Tools for research ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
22 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... of available P2 receptor antagonists are relatively weak and only mar- ginally selective for one P2 receptor... subtype over another. These antagonists also interact with other ATP ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 Norepinephrine Modulates Glutamatergic Transmission in the Bed Nucleus of the Stria Terminalis
 

Summary:  that it is mediated primarily via the a2A-AR, and to some degree the a2B and/or a2C-ARs. In the dBNST, both... .675.1% depression; n ¼ 6, po0.05, Figure 3d, f), suggesting the involvement of the a2B-AR and/or a2C-AR. b... the additional potential ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine

 
24 Current Topics in Medicinal Chemistry 2004, 4, 1485-1495 1485 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  Disc. 2003, 2, 703-716. [13] Giblin, P.A., and Kelly, T.A. Antagonists of 2 integrin-mediated cell... Bentham Science Publishers Ltd. Therapeutic Antagonists and the Conformational Regulation of the 2... of small molecule inhibitors, termed I allosteric and / I-like allosteric antagonist, have recently been

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
25 DEPENDENCE ON METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION BUT ENTRY IN THE GENESIS OF NOVEL CONVULSANT-INDUCED
 

Summary:  forms of synchronous bursting throughout the spinal neuraxis: (1) bursting mediated via electrical... transmission, independent of ionotropic receptors, and (2) bursting mediated chemically in the absence... -spectrum mGluR antagonist MCPG (n=3/3) & the group I mGluR subtype 1 antagonist AIDA (n=3/4). (2) ...

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
26 Hypocretins (1 and 2, aka. Orexin A and B) are neuropeptides synthesized in the lateral hypothalamus and are important contributors to arousal state, thermoregulation and
 

Summary:  antagonist, 3nM) on baseline fictive ventilation (5% CO2) and on the response to hypercapnia (10% CO2 ) were... for hypocretinergic modulation. Hypocretin-1 and hcrt-r antagonists in vitro · Exogenous application of hypocretin-1... preparation, nor does it alter the hypercapnic response in situ. · Hcrt-r1 antagonists reduce ...

  

Source: Wagner, Diane - Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks

 

Collection: Environmental Sciences and Ecology

 
27 Department of Biology Sponsor: American Cancer Society
 

Summary:  is mediated by the human estrogen receptors (ERs), and these breast cancers are treatable by ER antagonists... Amount: $687,000 Aptamer-Mediated Sub-Molecular Modulation of Estrogen Receptor Activities More than half... . Currently, all ER antagonists in clinical use bind to one site on ER. This project will ...

  

Source: Knuth, Kevin H. - Department of Physics, State University of New York at Albany

 

Collection: Physics

 
28 Neuropharmacology of alcohol addiction V Vengeliene, A Bilbao, A Molander and R Spanagel
 

Summary:  oxide; NPY, neuropeptide Y; NR1, NMDA receptor subunit 1; NR2A­D, NMDA receptor subunits 2A, 2B, 2C... , 1999). Furthermore, alcohol concentrations lower than 100 mM are known to potentiate only a2b4, a4b4, a... ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
29 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  antagonist [61, 62]; ADP has been shown to mediate the mid-portion and peak of coronary reactive hyperaemia... are mediated by an increase of cAMP and antagonists of these receptors are important drugs for the treatment... contraction varies between vascular beds [25]. For example, it may ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
30 Selective Blockade of the Mineralocorticoid Receptor Impairs Hypothalamic-Pituitary-Adrenal Axis Expression of Habituation
 

Summary:  injected s.c. with either vehicle (propylene glycol) or one of three corticosteroid receptor antagonist... treatments: selective MR antagonist (RU28318 or spironolactone), selective GR antagonist (RU40555), or both... MR and GR antagonists combined (RU28318+RU40555). Blood samples were collected for ...

  

Source: Spencer, Robert L. - Department of Psychology, University of Colorado at Boulder

 

Collection: Biology and Medicine

 
31 Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red
 

Summary:  microelectrode, voltage- clamp techniques (Axoclamp 2A & 2B amplifiers; Axon Instruments, Union City, CA, U... , purified of lipophilic contaminants, blocked P2X1R and P2X3R by acting as an insurmountable antagonist. 3... antagonist at P2X1R (IC50, 1.4 mM), whereas extract B was a ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
32 ABBREVIATIONS: NMDA, N-methyl-D-aspartic acid; ACPD, 1-aminocyclopentane-1 ,3-dicarboxylic acid; AMPA,a-amino-3-hydroxy-5-methyli-soxazole-4-propionic acid; BAPTA, 1 ,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; DMSO, dimethylsulfoxide; DNQX, 6
 

Summary:  : NMDA receptor (NR)1 A/2A, 29 nM; NR1 A/2B, 300 nM; NR1A/2C, 120 nM; NR1A/2D, 1500 nM. Measurement of EC... :1 mixtures of cRNA (NR1A plus NR2A, -2B, -2C, or -2D; -2, 5, or 20 ng of RNA encoding each receptor subunit... was combined with a single NR2 subunit, either ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
33 Calcium Signaling in Specialized Glial Cells MONICA R. METEA AND ERIC A. NEWMAN*
 

Summary:  increases (Fries et al., 2005; Reifel Saltzberg et al., 2003). Activation of A2B aden- osine receptors... is mediated by release of ATP. Waves are blocked by P2Y receptor antagonists but not by TTX or by glutamate... . Neuron to Muller cell signaling is mediated by ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
34 ARE UNCONVENTIONAL NMDA RECEPTORS INVOLVED IN SLOWLY ADAPTING TYPE I MECHANORECEPTOR RESPONSES?
 

Summary:  for NR2A/2B was identified with CK 20-stained Mer- kel cells. Staining for NF70 allowed selective... /kai- nate receptor antagonists (CNQX and NBQX, 100 M) had no effect, nor did classical competitive NMDA... receptor antago- nists, D-AP5 (600 M) and R-CPP (100 M), nor the NMDA glycine site ...

  

Source: Cahusac, Peter - Department of Psychology, University of Stirling

 

Collection: Biology and Medicine

 
35 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  in the agonist-mediated recruitment of the A2b receptor to the membrane. The colonic epithelial cell line T84... and SNAP-23, participate in the recruitment of the A2b receptor; and 4) the SNARE-mediated recruitment... in ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
36 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  affinity. The most selective A2B recep- tor antagonist is MRS1754. MRE3008-F20 is the most selective human... Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... are negatively coupled to adenylate cyclase ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
37 470 nature neuroscience volume 1 no 6 october 1998 In the cerebral cortex, extrinsic and intrinsic excitatory
 

Summary:  illustrated in Fig. 6a2. (b) O-LM interneuron illustrated in Fig. 6a3. a b Time (s) APrate(Hz) ATPA I(pA) V... and to the local inhibitory interneurons. Fast glutamatergic neurotransmis- sion is mediated by three classes... of ionotropic receptors, namely NMDA, AMPA and kainate receptors. Fast GABAergic ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
38 Brain Research 932 (2002) 9198 www.elsevier.com/locate/bres
 

Summary:  subtype as compared to the 5-HT and changes were again used for quantitative purposes. In each2A 2B 5-HT... receptor3 2 classification. We examined this possibility by using a selective agonist and two antagonists... of the vertebrate 5-HT receptor subtypes.2 The antagonist ketanserin ...

  

Source: Cooper, Robin L. - Department of Biology, University of Kentucky

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
39 Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion
 

Summary:  was abolished by the A1 antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) but was unaffected by A2a , A2b... and the amplitude of NECA-evoked current. D, E, Antagonists to A2A (ZM 241385), A2B (MRS 1706), and A3 (MRS ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
40 pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799
 

Summary:  (A1, A2A, A2B, and A3) have been considered as poten- tial therapies for neurodegenerative,4... ligands was also assessed for A1 and A3 AR subtypes expressed in mammalian cells (A2B subtype selec... Receptor Antagonists Vsevolod Katritch,*,,,§ ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
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41 Blockade of the NPY Y5 receptor potentiates circadian responses to light: complementary in vivo and in vitro studies
 

Summary:  effect was probably mediated by the Y5 receptor, since co-application of Y5 receptor antagonists... an antagonist to NPY receptors can be used to potentiate photic phase shifts late in the subjective night. First... completely reversed the effect of NPY, while application of a Y1 receptor antagonist had no ...

  

Source: Harrington, Mary - Department of Psychology, Smith College

 

Collection: Biology and Medicine

 
42 GLUTAMATE-ASSOCIATED PLASTICITY IN THE VENTRAL TEGMENTAL AREA IS NECESSARY FOR CONDITIONING
 

Summary:  antagonists observed here are mediated by blockade of DA release. For example, glutamate antagonists have... -VTA glutamate antagonist ad- ministration observed here may be mediated outside the VTA in one of many VTA... of either the NMDA antagonist AP5 (0.48 nmol/0.3 ...

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collection: Biology and Medicine

 
43 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... relaxation A2B Large intestine, bladder Role in allergic and inflammatory disorders; vasodilatation A3 Lung... Signaling The Periphery Adenosine A1, A2A, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
44 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... AbstractöIn a previous study we used P2 receptor antagonists to inhibit diverse responses that nerve growth... was excluded, whereas various antagonists of P2 receptors were ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
45 BIOLOGY OF REPRODUCTION 78, 688696 (2008) Published online before print 12 December 2007.
 

Summary:  some actions of PGF2a may not be mediated by EDN1, because the concentration of EDNRA antagonist used... .1095/biolreprod.107.064105 Effects of Endothelin Receptor Type-A and Type-B Antagonists on Prostaglandin F2alpha... by sustained administration of a type-A endothelin (EDNRA) or type-B endothelin (EDNRB) ...

  

Source: Wells, Jeffrey D. - Department of Biology, West Virginia University

 

Collection: Biology and Medicine

 
46 J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW
 

Summary:  in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... of antagonists to P2X4 and P2X7 receptors expressed by microglial cells in neuropathic and inflammatory pain... ; and the complex actions mediated by P2X7 receptors. Some ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  , immune responses, inflammation, pain, platelet aggregation, endothelial-mediated vasodilatation, cell... subtypes expressed in oocytes or other cell types is often different from the pharmacology of P2Y-mediated... of mammalian P2Y1 receptors [34], and MRS 2179 is a potent antagonist [35]; MRS 2269 and MRS 2286 have been

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
48 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... -induced relaxations to the P1 receptor antagonist 8pSPT suggests that the effect of ATP may be partly mediated through... adenosine. This is suggestive of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... on the central projections of primary afferent neurons in lamina II of the dorsal horn mediate facilitation... and specific- ity. Specific agonists and antagonists are available for the P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
50 Published: February 07, 2011 r 2011 American Chemical Society 420 dx.doi.org/10.1021/ci100375b |J. Chem. Inf. Model. 2011, 51, 420433
 

Summary:  receptors (2A, 2B, and 2C) are major drug targets for schizophrenia, feeding disorders, perception, depres... for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors Soo-Kyung Kim, Youyong Li, Ravinder... to highly potent and selective 5-HT2B antagonist PRX-08066 3, ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
51 The Sexually Antagonistic Genes of Drosophila melanogaster
 

Summary:  The Sexually Antagonistic Genes of Drosophila melanogaster Paolo Innocenti*, Edward H. Morrow... forces are said to be sexually antagonistic. Although the phenotypic effect of these genes has been... genetic framework, we identified a group of candidate genes experiencing sexually antagonistic selection

  

Source: Jackman, Todd - Biology Department, Villanova University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
52 Anna Zachariou, Tencho Tenev, Lakshmi Goyal1
 

Summary:  . In cells destined to die this IAP-mediated inhibition of caspases is overcome by IAP-antagonists. Genetic... evi- dence indicates that IAP-antagonists are non-equiva- lent and function synergistically to promote... and Jafrac2. We ®nd that these IAP-antagonists display differential and selective binding to ...

  

Source: Steller, Hermann - Laboratory of Apoptosis and Cancer Biology, Rockefeller University

 

Collection: Biology and Medicine

 
53 Corresponding author: Didier PELAPRAT Neurotensin receptor antagonist administered during cocaine withdrawal
 

Summary:  of the drug, followed by a one- week drug-free period and a subsequent cocaine challenge (Figs. 1A, 1B, 2A, 2B... Corresponding author: Didier PELAPRAT 1 Neurotensin receptor antagonist administered during cocaine... in these phenomena. We and others have reported that SR 48692, a neurotensin receptor ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
54 Perspectives in Pharmacology In Vivo Gene Modification Elucidates Subtype-Specific
 

Summary:  -selective pharmacological agents. Mice with a deletion (knockout) of the 2A-, 2B-, or 2C-gene as well as a point mutation... , and as adjuncts to general anesthesia. 2-Adrenergic receptors have been divided into three subtypes ( 2A, 2B... with these mice indicate that ...

  

Source: Kable, Joe - Center for Cognitive Neuroscience & Department of Psychology, University of Pennsylvania

 

Collection: Biology and Medicine

 
55 Adenosine Receptor, Protein Kinase G, and p38 Mitogen-Activated Protein Kinase-Dependent Up-Regulation of
 

Summary:  to inhibitory Gi/o proteins (A1 and A3 receptors), stimulatory Gs proteins (A2A and A2B receptors), as well... as Gq protein-linked PLC (A1, A2B, and A3 receptors) (Feoktistov and Biaggioni, 1997; Fred- holm et al... cells can produce AR-stimulated SERT activity in a ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine

 
56 APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Dec. 2010, p. 82558258 Vol. 76, No. 24 0099-2240/10/$12.00 doi:10.1128/AEM.00499-10
 

Summary:  to additional screening. We identified nine antagonists (X2 to X10) and 14 agonists (A1 to A14) of LasR-mediated... , we have identified nine nonnative antagonists and 14 nonnative agonists of LasR-mediated gene... in a cell-density-dependent manner to regulate gene expression (15). Archetypal ...

  

Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
57 Purinergic signalling *Geoffrey Burnstock
 

Summary:  2B and A3 (see Ralevic & Burnstock, 1998). All P1 adenosine receptors are typical G protein... roles in exocrine and endocrine secretion, platelet aggregation, vascular endothelial cell-mediated... that autonomic control of smooth muscle consisted of antagonistic sympathetic noradrenergic and ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
58 PLATELET-ACTIVATING FACTOR AFFECTS NOCICEPTION IN RATS AT CEREBRAL SITES OF ACTION
 

Summary:  platelet-activating factor (PAF) antagonists that block either plasma membrane or intracellular PAF binding... sites attenuate the late-phase nociceptive response to formalin in rats. Inasmuch as these antagonists... suggested that PAF may be an important central mediator of inflammatory-based pain. In the present study we

  

Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
59 R E V I E W S NATURE REVIEWS | DRUG DISCOVERY VOLUME 2 | SEPTEMBER 2003 | 703
 

Summary:  of the integrin family of adhesion molecules are non-covalently-associated / heterodimers that mediate cell... efforts have been directed towards the discovery and develop- ment of integrin antagonists for clinical... not only on antagonists of integrins as promising therapeutics,but also on what the drug discovery litera

  

Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University

 

Collection: Biology and Medicine

 
60 Neuropharmacology 40 (2001) 749760 www.elsevier.com/locate/neuropharm
 

Summary:  antagonist against NMDA-induced currents in Xenopus oocytes expressing NR1-1a/2A or NR1-1a/2B receptors... oocytes The rat cRNAs encoding the subunit NR1-1a and the subtypes NR2A/2B were obtained from JP... the physiologically distinct NR1-1a/2A ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine


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61 Behavioral/Systems/Cognitive Steroid Hormones Act Transsynaptically within the
 

Summary:  ,Spontaneousfiringrate(mean SEM).A2,B2,Cumulativefrequency distributions of firing rates (see Results for statistical... com- paredwiththenoninfusedhemisphere.A2,B2,C2... . A2, B2, The cumulative frequency ...

  

Source: Hopkins, William A. - Department of Fisheries and Wildlife Sciences, Virginia Tech

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
62 Augmentation of antidepressive effects of SSRIs by co-administration of 5-HT2C antagonists. Augmentation of antidepressive effects of SSRIs
 

Summary:  Augmentation of antidepressive effects of SSRIs by co-administration of 5-HT2C antagonists. 185... Chapter 9 Augmentation of antidepressive effects of SSRIs by co-administration of 5-HT2C antagonists. #12... of antidepressant treatment by co-administration of an SSRI with a 5-HT2C antagonist. Initially we observed

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
63 UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors
 

Summary:  . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... gap junction-mediated buffering of K+ and metabolites, leading to prolonged activation of cells... or protracted, in the release of proinflammatory mediators, amongst which ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
64 nature neuroscience volume 4 no 4 april 2001 417 Glutamate is the predominant excitatory neurotransmitter in
 

Summary:  found no effect of an mGluR1 antagonist on peripheral mGluR-mediated mechanical hyper- articles Fig. 6... GluR antagonists attenuate nociceptive scores during the for- malin test, a model used to study inflammatory pain... suggest that glutamate is a true peripheral inflammatory mediator released after tissue ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
65 CANCER CELL : JANUARY 2004 VOL. 5 COPYRIGHT 2004 CELL PRESS 1 Ever since the discovery of caspases as
 

Summary:  caspases, caspase-3 and -7 (Figure 1). By doing so, it acts as a brake on caspase-mediated cellular... molecule combinatorial libraries for compounds that relieve XIAP-mediated caspase-3 inhibition. At least... . These com- pounds specifically reversed XIAP- mediated inhibition of caspase-3 and caspase-7

  

Source: Wu, Hao - Department of Biochemistry, Cornell University

 

Collection: Biology and Medicine

 
66 Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India
 

Summary:  the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... nervous system. P2X3 receptor antagonists are being explored for alleviating renal colic. ATP contracts... neurons, which was mimicked by ATP and reduced by ATP antagonists [15] ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
67 RESEARCH PAPER Role of ATP and related purines in inhibitory
 

Summary:  , Table 3). Effects of A1, A2A, A2B and A3 receptor antagonists on relaxations to EFS, adenosine and NECA... M) and MRS1220 (10 mM), A1, A2B and A3 receptor antagonists, respectively, failed to modify these responses... MV, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
68 Kidney International, Vol. 64 (2003), pp. 13891397 Unusual absence of endothelium-dependent or -independent
 

Summary:  - sions followed: P1 receptors into A1, A2A, A2B, and A3 and P2 receptors into P2X and P2Y subtypes based... [38, 39]. Simi- larly, an inhibitory adenosine A2b receptor located on rat renal endothelial cells... of antagonists to P2X receptors and ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
69 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 ago... - nists) and depression (galanin receptor antagonists). The A2A=D2, A2A=D3 and A2A=mGluR5 heteromers... of high affinity 3H-5-HT binding sites and D2 antagonist binding sites, respectively in membrane prepara

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
70 Long-acting Opioid Antagonists Disrupt Receptor Signaling and Produce Noncompetitive Effects by Activating c-Jun
 

Summary:  as an antagonist for KOR-mediated signal transduction (6, 8, 10). For example norBNI has been shown to block... Long-acting Opioid Antagonists Disrupt Receptor Signaling and Produce Noncompetitive Effects... (KOR) antagonists having very long durations of action in vivo despite binding non-covalently in vitro

  

Source: Bruchas, Michael R. - Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
71 PharmacologyBiochemistry&Behavior,Vol.33, pp. 273-279. PergamonPressplc, 1989.Printedin the U.S.A. 0091-3057/89$3.00 + .00 The Effects of Selective Dopamine
 

Summary:  with inter- mediate to high doses of the D2 antagonist produced significant place preferences. Recently... .S.A. 0091-3057/89$3.00 + .00 The Effects of Selective Dopamine D1 or D2 Receptor Antagonists... ability of the dopamine D1 antagonist, SCH 23390 (0.01, 0.1, 1.0, 2.0 mg/kg) or the D2 ...

  

Source: Beninger, Richard J. - Department of Psychology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
72 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  -selective antagonists used were DPCPX (A1 selective; Ki 0.3­4.0 nM), ZM-241385 (A2a selective; Ki 0.5 nM), MRS-1754 (A2b... -241385 (0.03 M), the A2b-selective an- tagonist MRS-1754 (0.08 M), or the A3-selec- tive antagonist ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
73 Multiple Limbic Regions Mediate the Disruption of Prepulse Inhibition Produced in Rats by the Noncompetitive NMDA
 

Summary:  . The neuroanatomical substrates mediating the PPI-disruptive effects of noncompetitive NMDA antagonists are unknown... indicate that multiple limbic forebrain regions mediate the ability of noncompetitive NMDA antagonists... . The neuroanatomical substrates mediating the PPI-disruptive ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
74 Open Access Available online http://arthritis-research.com/content/8/4/R114
 

Summary:  -lymphocyte function with tumour necrosis factor antagonists Haïfa Hamdi1*, Xavier Mariette2*, Véronique Godot1, Karin... understood. We evaluated the effect of the TNF antagonists infliximab (Ifx), adalimumab (Ada) and etanercept... treated with TNF antagonists and with the in vitro addition of TNF ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
75 Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal Neurons
 

Summary:  equally by competitive antagonists. If the two forms of inhibitory conductance are mediated by separate... Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal... of Medicine, Los Angeles, California 90095 A tonic inhibitory conductance mediated by GABAA receptors

  

Source: Journal Neuroscience -- Rapid Communications

 

Collection: Biology and Medicine

 
76 International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 V. Agonists and antagonists... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291 A. Chemical structure of agonist and antagonist ligands... of selective agonists ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
77 A. Specific Aims Presynaptic terminals are key sites for neural integration every bit as complex as their postsynaptic targets and
 

Summary:  and Ca2+ -synaptotagmin show a mutually antagonistic competition for interaction with the SNARE complex... . We seek to demonstrate that, because G competes with Ca2+ -synaptotagmin binding, GPCR- mediated... the antagonistic interaction between G and Ca2+ -synaptotagmin at SNARE complexes. We will perform

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
78 NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant c Oscillations Independent of
 

Summary:  increased the power of c oscillations all over the recorded cortical areas (Fig. 3A2,B2; N = 6 rats). 3... receptor (NMDAr) antagonists, induce cognitive impairment and aggravate schizophrenia symptoms... ) electrocorticogram (ECoG). This study investigated whether NMDAr ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
79 Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes
 

Summary:  Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes Lei Zhou1... of extensive sequence divergence, no orthologue was identified for the reaper/grim-like IAP antagonist genes... identified michelob_x(mx), a gene not predicted by the genome project, as the missing IAP antagonist

  

Source: Severson, David - Department of Biological Sciences, University of Notre Dame

 

Collection: Biology and Medicine

 
80 vol. 162, no. 2 the american naturalist august 2003 Coevolution in Temporally Variable Environments
 

Summary:  and p2 are given by T 1 p p , (A2a)1,T 1,0 ( )1 c T 1 p p , (A2b)2,T 2,0 tp0 1 bt where... ; Kapan 2001; Thompson et al. 2002) or by selection that may be antagonistic at certain points in time... - tualistic and antagonistic selection have considered only spatial variation. This work ...

  

Source: Gomulkiewicz, Richard - School of Biological Sciences, Washington State University; Nuismer, Scott L. - Department of Biological Sciences, University of Idaho

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology ; Mathematics


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81 The Journal of Neuroscience, December 1991, f f(12): 39303939 Opiate Withdrawal-induced Hyperactivity of Locus Coeruleus
 

Summary:  -induced Hyperactivity of Locus Coeruleus Neurons Is Substantially Mediated by Augmented Excitatory Amino Acid Input... of the opiate antagonist naloxone (0.1 mg/kg, i.v.) robustly increased the activity of LC neurons. Local... of kynurenate, a broad- spectrum antagonist of excitatory amino acids (EAAs), sub- stantially but ...

  

Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina

 

Collection: Biology and Medicine

 
82 Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain
 

Summary:  Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit... that blockade of corticotropin-releasing factor (CRF) receptors with a nonspecific CRF1/CRF2 receptor antagonist... , the nicotinic receptor antagonist mecamylamine elevated the brain reward thresholds of the nicotine- dependent

  

Source: Príncipe, José Carlos - Computational NeuroEngineering Laboratory, University of Florida

 

Collection: Engineering ; Computer Technologies and Information Sciences

 
83 ELSEVIER Neuroscience Letters 175 (1994) 166--170 NHROSClENCE
 

Summary:  activity at the a2B- adrenergic receptor [9], in addition to its well-described action at al... , who used a larger number of antagonists, and con- cluded that NE sensitization is mediated through... mechanical threshold. In the presence of the ~2-adrenergic ...

  

Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles

 

Collection: Biology and Medicine

 
84 Summary and conclusions Summary and Conclusions
 

Summary:  inhibition in one molecule (e.g. #12;Chapter 10 202 venlafaxine) or serotonin receptor antagonists that also... investigated for their use in the clinic (e.g. substance P antagonists, corticosteroid (releasing factor... ) antagonists and the herbal preparation St. John Worth), but these fall beyond the scope of this thesis. By ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
85 Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure in Endotoxemic Mice
 

Summary:  Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure... (TxA2) may mediate decreases of renal blood flow (RBF) and/or GFR associated with LPS- induced sepsis... or a selective TP receptor antagonist (SQ29,548), would alleviate LPS-induced renal vasoconstriction and ARF

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
86 Molecular Psychiatry (2001) 6, 615617 2001 Nature Publishing Group All rights reserved 1359-4184/01 $15.00
 

Summary:  pain mediator, and that inhibitors of glu- tamate release, glutamate receptors, or inhibitors... and neuropathic pain states, since antagonists of mGluR1 and 5 reduce hyp- eralgesia following peripheral... , and that these receptors might mediate a component of inflammatory hyperal- gesia. As predicted, the expression of mGluR5

  

Source: Gereau, Robert W. IV - Basic Research Division, Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
87 Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies Augmentation of SSRI effects on serotonin by 5-
 

Summary:  antagonists are observed during basal conditions, this receptor is only mediating an effect on #12;Chapter 4... (2):83-91. Slattery DA, Desrayaud S, Cryan JF (2005) GABAB receptor antagonist-mediated antidepressant- like behavior... Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
88 Structure based prediction of subtype-selectivity for adenosine receptor antagonists
 

Summary:  )phenylxanthines: development and character- ization of adenosine A2B receptor antagonists and a new radioligand with sub... -deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor. Bioorg. Med. ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
89 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  neuromodulator that binds to at least four known G-protein- coupled receptors in the brain (A1, A2A, A2B, and A3... adenosinergic system, and to characterize potential target sites where A2AR and mGluR5 antagonists could mediate... be mediated, pre-embedding electron ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
90 Allosteric Modulation of 2-Adrenergic Receptor by Zn2 GAYATHRI SWAMINATH, JACQUELINE STEENHUIS, BRIAN KOBILKA, and TAE WEON LEE
 

Summary:  function in vivo. The 2-adrenergic receptor ( 2AR) mediates adrenergic responses in both the central... and Bmax values for the antagonist dihydroalprenolol (DHA). These results demonstrate that Zn2... previously (Kobilka, 1995). Membrane Binding Assays. Antagonist binding assays were done with membranes

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
91 oo26-895x196/o3o54o-o7$3.oo/o Copyright by The American Society for Pharmacology and Experimental Therapeutics
 

Summary:  ; Accepted November 28, 1995 SUMMARY Whole-cell recordings were used to study the antagonist phar- macology... with a Kb of 6 p.M while inhibiting AMPA receptors with a Kb of >100 p.M. The remaining antagonists showed... competitive antagonists block native AMPA and kainate receptors with approximately similar potencies, which

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
92 Vas deferens A model used to establish sympathetic cotransmission
 

Summary:  release via A2A receptors in the epididymal portion and via A2B receptors in the prostatic portion... receptors in the epididymal portion and adenosine A2B receptors in the prostatic portion of the rat vas... , although P- and Q-type channels also ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
93 Genetica 116: 179188, 2002. 2002 Kluwer Academic Publishers. Printed in the Netherlands.
 

Summary:  The evolution of hybrid infertility: perpetual coevolution between gender-specific and sexually antagonistic... of experimental research from Drosophila melanogaster that demonstrate that sexually antagonistic fitness... states that the expression of sexually antagonistic genes leads to a `gender-load' in each sex

  

Source: Rice, William - Department of Ecology, Evolution, and Marine Biology, University of California at Santa Barbara

 

Collection: Environmental Sciences and Ecology

 
94 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... 58261 Gs : cAMP A2B Large intestine, bladder NECA Enprofylline Gs : cAMP A3 Lung, liver, brain, testis... of purine-mediated signalling has ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
95 Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets
 

Summary:  was assessed by measuring the median platelet volume (MPV). The P2Y1 receptor antagonist MRS 2179 (1.06 À 10... antagonist AR-C69931MX significantly inhibited (at 10s, P ¼ 0.009; 15 s, P ¼ 0.001 and 30 s, P ¼ 0.015) ADP... -induced PSC. The P2X1 receptor antagonist TNP-ATP had no significant effect on ADP- or ADP þ ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
96 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  proliferation is mediated by A2A and A2B receptors, and some of the mitogenic effects are mediated via... (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... - stration that ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
97 Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies Augmentation of antidepressant effects of SSRIs by
 

Summary:  . Slattery, S. Desrayaud, and J. F. Cryan. GABA(B) receptor antagonist-mediated antidepressant- like behavior... Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies 205... Chapter 8 Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies #12

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
98 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS GPCR 3D homology models for ligand
 

Summary:  3, (no sufficient data for A2b subtype), as well as to select AA2AR antagonists ver- sus AA2AR... structure of AA2AR in selecting known antagonists from decoys, as well as from antagonists for other... Wiley-Liss, Inc. Key words: adenosine receptor; GPCR structure; ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
99 PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Thangapandian, Sundarapandian]
 

Summary:  and are themselves modulated upon the effects of histamine [7­9]. Histamine was discovered as a mediator... . Histamine mediates its function through four receptor subtypes namely, H1, H2, H3 and H4 [10... to specific agonists and antagonists and by their molecular weight [12­14]. Each receptor subtype is expressed

  

Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University

 

Collection: Biotechnology ; Biology and Medicine

 
100 CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate
 

Summary:  synapses this may be mediated by endocannabinoids. We evaluated whether the selective cannabinoid type 1... (CB1) receptor antagonists SR 141716 or AM 251 could modify induction of epileptiform activity... reduced by CB1 receptor antagonists, SR 141716 or AM 251. Minimal effects on epileptiform activity were

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine


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