| Sample search results for: a2b antagonist mediate |
| 1 | Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists | ||
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Summary: log b b2 a2 b b2 a2 . (7) tions of antagonist. Each current is the sum of 500 single channel traces... a minor semiaxis, a, and a major semiaxis, b, with surface area given by (Levy, 1995) Area 2 b2 a2 b b2 a2... , of such an object is given by ... |
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Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 2 | NMDA receptor subunits: function and pharmacology Pierre Paoletti and Jacques Neyton | ||
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Summary: 2A>>2B>2C 2D - partial antagonist >100-fold (maximal inhibition ~70%) - glutamate affinity - low... "efficacy" on NR1/2A/2B and NR1/2A/2C triheteromeric receptors 2B>>2A 2C 2D - partial antagonist ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 3 | 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 53:281291 (2001) | ||
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Summary: -4), histamine (H1), serotonin (5-HT3) or adenosine (A1 and A2B) receptors [Lambrecht et al., 1992, 2000; Boyer... , a novel functionally selective antagonist of P2 purinoceptor- mediated responses. Eur J Pharmacol 217... can be altered at the pyridoxal and phenyl moieties to produce P2X1 ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 4 | Vol. 275, No. 3 Printed in U.S.A. | ||
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Summary: combi- nations of cloned rat NMDA receptors (NR1NNR2A, 2B, 2C or 2D) ranged from 0.4 to 8 M (1 M glycine... with either NR2A, 2B, 2C or 2D. Currents elicited by activation of cloned receptors were similar to those... .4, 5.1) 0.31 (2.8, 3.4) 3 3 5 3 NMDA receptor ... |
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Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 5 | GABAA and GABAB Antagonists Differentially Affect the Firing Pattern | ||
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Summary: a pacemaker pattern (A2). B: After application of picrotoxin, both neurons show a marked switch to a bursty... by local application of bicuculline (A2, B2, C2). A1, B1: No significant correlation was found between pre... GABAA and GABAB ... |
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Source: Tepper, James M. - Center for Molecular and Behavioral Neuroscience, Rutgers University at Newark |
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Collection: Biology and Medicine |
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| 6 | ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and | ||
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Summary: , A2B and A3, and, in 1985, Burnstock and Kennedy proposed a basis for distinguishing between two... of adenosine triphosphate, adenosine diphosphate, uridine triphosphate and adeno- sine. These molecules mediate... . The antithrombotic action of clopidogrel (Plavix), a P2Y12 receptor ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 7 | Transient Plasticity of Hippocampal CA1 Neuron Glutamate Receptors Contributes to Benzodiazepine | ||
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Summary: antagonists. Neurons were voltage-clamped from À80 to þ 40 mV in cSEVC. NMDAR-mediated EPSCs were elicited... M, perhaps sufficient to potentiate GABAR-mediated inhibition. Therefore, the effect of the BZ antagonist... receptor (AMPAR)-mediated and reduced NMDA receptor ... |
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Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo |
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Collection: Biology and Medicine |
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| 8 | Benzodiazepine-induced hippocampal CA1 neuron alph...[Behav Pharmacol. 2007] -PubMed Result Behav Pharmacol. 2007 Sep;18(5-6):447-60. Links | ||
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Summary: AMPAR-mediated neuronal overexcitation. NMDAR antagonist administration (MK-801, 0.25 mg/ kg... was observed between increased AMPAR-mediated mEPSC amplitude and anxiety-like behavior in 1-day FZP... -withdrawn rats. These effects were disrupted by systemic AMPAR antagonist administration (GYKI-52466, 0.5 mg/ ... |
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Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo |
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Collection: Biology and Medicine |
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| 9 | Summary and conclusions Summary and conclusions | ||
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Summary: as the development of specific receptor antagonists with serotonin reuptake inhibition (nefazodone, trazodone). More... interaction which can mediate antidepressant effects (glucocorticoids, corticotrophin releasing factor... of action. It is hoped that some of the data may lead to a better understanding of how SSRIs mediate |
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Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 10 | Rational discovery of novel nuclear hormone receptor antagonists | ||
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Summary: light on the LBD structural changes mediated by NR antagonists (11, 12): ER agonists and antagonists... Rational discovery of novel nuclear hormone receptor antagonists Matthieu Schapira* , Bruce M... , with the exception of the human estrogen receptor- , the lack of antagonist-bound ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 11 | NPY signaling through Y1 receptors modulates thalamic oscillations | ||
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Summary: antagonists; Fig. 3A2, B2 and C2 show single oscillations under all experimental conditions. Results were... . Oscillations grow weaker over time and eventually stop (see traces in Figs. 2 and 3 A2, B2 and C2... of the three Y receptor agonists. ... |
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Source: Huguenard, John R. - Department of Neurology and Neurological Sciences, Stanford University |
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Collection: Biology and Medicine |
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| 12 | doi: 10.1098/rstb.2005.1788 , 277-2853612006Phil. Trans. R. Soc. B | ||
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Summary: coevolution Detecting sexual conflict and sexually antagonistic References http... antagonistic coevolution Locke Rowe1,2,* and Troy Day3,4 1 Department of Zoology, University of Toronto... conflict and resultant sexually antagonistic coevolution. We then use published empirical examples |
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Source: Rowe, Locke - Department of Ecology and Evolutionary Biology, University of Toronto |
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Collection: Environmental Sciences and Ecology |
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| 13 | Novel Treatment for Stroke, Brain Trauma, Alzheimer's Disease and | ||
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Summary: cell death, unlike previous non-specific NMDA receptor antagonists Principal Inventor(s): Dr. Yu Tian... Wang Publications/References: Liu Y, et al. NMDA receptor subunits have differential roles in mediating... damage following stroke or brain trauma is largely due to excitoxicity mediated by excessive release |
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Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia |
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Collection: Engineering |
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| 14 | Detecting sexual conflict and sexually antagonistic coevolution | ||
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Summary: Detecting sexual conflict and sexually antagonistic coevolution Locke Rowe1,2,* and Troy Day3,4 1... approaches for detecting interlocus sexual conflict and resultant sexually antagonistic coevolution. We... attributes emerge. First, the dynamics of sexually antagonistic coevolution may obscure the conflict itself |
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Source: Day, Troy - Departments of Mathematics and Statistics & Biology, Queen's University (Kingston) |
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Collection: Environmental Sciences and Ecology |
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| 15 | Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK | ||
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Summary: receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... pathophysiological roles of ATP, ADP, UTP and adenosine. These molecules mediate short-term (acute) signalling... receptor antagonist, has been shown to be particularly useful in the ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 16 | The Novel Antipsychotic Drug Lurasidone Enhances NMDA Receptor-Mediated Synaptic Responses | ||
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Summary: subunits remained similar in saline- vs. lurasidone-injected animals (total NR2A/2B/1: 0.9±0.2 fold... MOL #76141 The Novel Antipsychotic Drug Lurasidone Enhances NMDA Receptor- Mediated Synaptic... produced a significant and selective enhancement of NMDAR-mediated synaptic responses and ... |
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Source: Yan, Zhen - Department of Physiology and Biophysics, State University of New York at Buffalo |
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Collection: Biology and Medicine |
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| 17 | BRIEF COMMUNICATION doi:10.1111/j.1558-5646.2010.01100.x | ||
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Summary: are the frequencies of the A2B1 haplotype; and x4, y4 are the frequencies of the A2B2 haplotype. We assemble... and male parent, respectively. A1B1 A1B2 A2B1 ... |
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Source: Úbeda, Francisco - Department of Ecology and Evolutionary Biology, University of Tennessee |
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Collection: Biology and Medicine |
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| 18 | Cellular/Molecular Calcium Increases in Retinal Glial Cells Evoked by Light- | ||
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Summary: . In the presence of 2 M NECA, the A2B receptor antagonist MRS 1706 (1 M) reduced the light-evoked Mu¨ller cell... that adenosine potentiation of Mu¨ller cell Ca2 responses is mediated primarily by A2B receptors, in ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 19 | The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine | ||
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Summary: depression A2A Brain, heart, lungs, spleen Facilitates neurotransmission; smooth muscle relaxation A2B Large... in neurotransmission and neuromodulation, with their effects being mediated by the purine and pyrimidine receptor... of methylxanthine antagonists21 . ADO also exerts central ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 20 | Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking | ||
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Summary: of Antagonist 1-850 and Derivatives on the T3-Mediated Binding of TR to the Coactivator NRC in Vitro. Full... by using a PhosphorImager. The results shown in Fig. 5 indicate that the antagonists block the T3-mediated... Discovery of diverse thyroid hormone receptor antagonists by ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 21 | Nonpeptide antagonists of neuropeptide receptors: Tools for research and therapy | ||
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Summary: antagonists interfere only with the actions of angiotensin II mediated by AT1 receptors. This might result... receptor mediated dopamine release from rat striatum6 . Both SR48968 and another NK2 antagonist, GR159897... Nonpeptide antagonists of neuropeptide receptors: Tools for research ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 22 | Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and | ||
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Summary: this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... of available P2 receptor antagonists are relatively weak and only mar- ginally selective for one P2 receptor... subtype over another. These antagonists also interact with other ATP ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 23 | Norepinephrine Modulates Glutamatergic Transmission in the Bed Nucleus of the Stria Terminalis | ||
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Summary: that it is mediated primarily via the a2A-AR, and to some degree the a2B and/or a2C-ARs. In the dBNST, both... .675.1% depression; n ¼ 6, po0.05, Figure 3d, f), suggesting the involvement of the a2B-AR and/or a2C-AR. b... the additional potential ... |
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Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University |
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Collection: Biology and Medicine |
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| 24 | Current Topics in Medicinal Chemistry 2004, 4, 1485-1495 1485 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd. | ||
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Summary: Disc. 2003, 2, 703-716. [13] Giblin, P.A., and Kelly, T.A. Antagonists of 2 integrin-mediated cell... Bentham Science Publishers Ltd. Therapeutic Antagonists and the Conformational Regulation of the 2... of small molecule inhibitors, termed I allosteric and / I-like allosteric antagonist, have recently been |
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Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University |
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Collection: Biology and Medicine |
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| 25 | DEPENDENCE ON METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION BUT ENTRY IN THE GENESIS OF NOVEL CONVULSANT-INDUCED | ||
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Summary: forms of synchronous bursting throughout the spinal neuraxis: (1) bursting mediated via electrical... transmission, independent of ionotropic receptors, and (2) bursting mediated chemically in the absence... -spectrum mGluR antagonist MCPG (n=3/3) & the group I mGluR subtype 1 antagonist AIDA (n=3/4). (2) ... |
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Source: Hochman, Shawn - Department of Physiology, Emory University |
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Collection: Biology and Medicine |
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| 26 | Hypocretins (1 and 2, aka. Orexin A and B) are neuropeptides synthesized in the lateral hypothalamus and are important contributors to arousal state, thermoregulation and | ||
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Summary: antagonist, 3nM) on baseline fictive ventilation (5% CO2) and on the response to hypercapnia (10% CO2 ) were... for hypocretinergic modulation. Hypocretin-1 and hcrt-r antagonists in vitro · Exogenous application of hypocretin-1... preparation, nor does it alter the hypercapnic response in situ. · Hcrt-r1 antagonists reduce ... |
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Source: Wagner, Diane - Institute of Arctic Biology, Department of Biology and Wildlife, University of Alaska Fairbanks |
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Collection: Environmental Sciences and Ecology |
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| 27 | Department of Biology Sponsor: American Cancer Society | ||
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Summary: is mediated by the human estrogen receptors (ERs), and these breast cancers are treatable by ER antagonists... Amount: $687,000 Aptamer-Mediated Sub-Molecular Modulation of Estrogen Receptor Activities More than half... . Currently, all ER antagonists in clinical use bind to one site on ER. This project will ... |
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Source: Knuth, Kevin H. - Department of Physics, State University of New York at Albany |
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Collection: Physics |
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| 28 | Neuropharmacology of alcohol addiction V Vengeliene, A Bilbao, A Molander and R Spanagel | ||
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Summary: oxide; NPY, neuropeptide Y; NR1, NMDA receptor subunit 1; NR2AD, NMDA receptor subunits 2A, 2B, 2C... , 1999). Furthermore, alcohol concentrations lower than 100 mM are known to potentiate only a2b4, a4b4, a... ... |
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Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health, |
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Collection: Computer Technologies and Information Sciences ; Biology and Medicine |
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| 29 | P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock | ||
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Summary: antagonist [61, 62]; ADP has been shown to mediate the mid-portion and peak of coronary reactive hyperaemia... are mediated by an increase of cAMP and antagonists of these receptors are important drugs for the treatment... contraction varies between vascular beds [25]. For example, it may ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 30 | Selective Blockade of the Mineralocorticoid Receptor Impairs Hypothalamic-Pituitary-Adrenal Axis Expression of Habituation | ||
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Summary: injected s.c. with either vehicle (propylene glycol) or one of three corticosteroid receptor antagonist... treatments: selective MR antagonist (RU28318 or spironolactone), selective GR antagonist (RU40555), or both... MR and GR antagonists combined (RU28318+RU40555). Blood samples were collected for ... |
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Source: Spencer, Robert L. - Department of Psychology, University of Colorado at Boulder |
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Collection: Biology and Medicine |
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| 31 | Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red | ||
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Summary: microelectrode, voltage- clamp techniques (Axoclamp 2A & 2B amplifiers; Axon Instruments, Union City, CA, U... , purified of lipophilic contaminants, blocked P2X1R and P2X3R by acting as an insurmountable antagonist. 3... antagonist at P2X1R (IC50, 1.4 mM), whereas extract B was a ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 32 | ABBREVIATIONS: NMDA, N-methyl-D-aspartic acid; ACPD, 1-aminocyclopentane-1 ,3-dicarboxylic acid; AMPA,a-amino-3-hydroxy-5-methyli-soxazole-4-propionic acid; BAPTA, 1 ,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; DMSO, dimethylsulfoxide; DNQX, 6 | ||
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Summary: : NMDA receptor (NR)1 A/2A, 29 nM; NR1 A/2B, 300 nM; NR1A/2C, 120 nM; NR1A/2D, 1500 nM. Measurement of EC... :1 mixtures of cRNA (NR1A plus NR2A, -2B, -2C, or -2D; -2, 5, or 20 ng of RNA encoding each receptor subunit... was combined with a single NR2 subunit, either ... |
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Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 33 | Calcium Signaling in Specialized Glial Cells MONICA R. METEA AND ERIC A. NEWMAN* | ||
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Summary: increases (Fries et al., 2005; Reifel Saltzberg et al., 2003). Activation of A2B aden- osine receptors... is mediated by release of ATP. Waves are blocked by P2Y receptor antagonists but not by TTX or by glutamate... . Neuron to Muller cell signaling is mediated by ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 34 | ARE UNCONVENTIONAL NMDA RECEPTORS INVOLVED IN SLOWLY ADAPTING TYPE I MECHANORECEPTOR RESPONSES? | ||
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Summary: for NR2A/2B was identified with CK 20-stained Mer- kel cells. Staining for NF70 allowed selective... /kai- nate receptor antagonists (CNQX and NBQX, 100 M) had no effect, nor did classical competitive NMDA... receptor antago- nists, D-AP5 (600 M) and R-CPP (100 M), nor the NMDA glycine site ... |
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Source: Cahusac, Peter - Department of Psychology, University of Stirling |
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Collection: Biology and Medicine |
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| 35 | Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins | ||
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Summary: in the agonist-mediated recruitment of the A2b receptor to the membrane. The colonic epithelial cell line T84... and SNAP-23, participate in the recruitment of the A2b receptor; and 4) the SNARE-mediated recruitment... in ... |
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Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 36 | This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the | ||
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Summary: affinity. The most selective A2B recep- tor antagonist is MRS1754. MRE3008-F20 is the most selective human... Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... are negatively coupled to adenylate cyclase ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 37 | 470 nature neuroscience volume 1 no 6 october 1998 In the cerebral cortex, extrinsic and intrinsic excitatory | ||
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Summary: illustrated in Fig. 6a2. (b) O-LM interneuron illustrated in Fig. 6a3. a b Time (s) APrate(Hz) ATPA I(pA) V... and to the local inhibitory interneurons. Fast glutamatergic neurotransmis- sion is mediated by three classes... of ionotropic receptors, namely NMDA, AMPA and kainate receptors. Fast GABAergic ... |
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Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm |
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Collection: Biology and Medicine |
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| 38 | Brain Research 932 (2002) 9198 www.elsevier.com/locate/bres | ||
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Summary: subtype as compared to the 5-HT and changes were again used for quantitative purposes. In each2A 2B 5-HT... receptor3 2 classification. We examined this possibility by using a selective agonist and two antagonists... of the vertebrate 5-HT receptor subtypes.2 The antagonist ketanserin ... |
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Source: Cooper, Robin L. - Department of Biology, University of Kentucky |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 39 | Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion | ||
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Summary: was abolished by the A1 antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) but was unaffected by A2a , A2b... and the amplitude of NECA-evoked current. D, E, Antagonists to A2A (ZM 241385), A2B (MRS 1706), and A3 (MRS ... |
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Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota |
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Collection: Biology and Medicine |
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| 40 | pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799 | ||
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Summary: (A1, A2A, A2B, and A3) have been considered as poten- tial therapies for neurodegenerative,4... ligands was also assessed for A1 and A3 AR subtypes expressed in mammalian cells (A2B subtype selec... Receptor Antagonists Vsevolod Katritch,*,,,§ ... |
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Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 41 | Blockade of the NPY Y5 receptor potentiates circadian responses to light: complementary in vivo and in vitro studies | ||
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Summary: effect was probably mediated by the Y5 receptor, since co-application of Y5 receptor antagonists... an antagonist to NPY receptors can be used to potentiate photic phase shifts late in the subjective night. First... completely reversed the effect of NPY, while application of a Y1 receptor antagonist had no ... |
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Source: Harrington, Mary - Department of Psychology, Smith College |
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Collection: Biology and Medicine |
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| 42 | GLUTAMATE-ASSOCIATED PLASTICITY IN THE VENTRAL TEGMENTAL AREA IS NECESSARY FOR CONDITIONING | ||
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Summary: antagonists observed here are mediated by blockade of DA release. For example, glutamate antagonists have... -VTA glutamate antagonist ad- ministration observed here may be mediated outside the VTA in one of many VTA... of either the NMDA antagonist AP5 (0.48 nmol/0.3 ... |
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Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina |
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Collection: Biology and Medicine |
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| 43 | Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson | ||
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Summary: as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... relaxation A2B Large intestine, bladder Role in allergic and inflammatory disorders; vasodilatation A3 Lung... Signaling The Periphery Adenosine A1, A2A, ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 44 | INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM | ||
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Summary: for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... AbstractöIn a previous study we used P2 receptor antagonists to inhibit diverse responses that nerve growth... was excluded, whereas various antagonists of P2 receptors were ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 45 | BIOLOGY OF REPRODUCTION 78, 688696 (2008) Published online before print 12 December 2007. | ||
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Summary: some actions of PGF2a may not be mediated by EDN1, because the concentration of EDNRA antagonist used... .1095/biolreprod.107.064105 Effects of Endothelin Receptor Type-A and Type-B Antagonists on Prostaglandin F2alpha... by sustained administration of a type-A endothelin (EDNRA) or type-B endothelin (EDNRB) ... |
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Source: Wells, Jeffrey D. - Department of Biology, West Virginia University |
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Collection: Biology and Medicine |
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| 46 | J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW | ||
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Summary: in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... of antagonists to P2X4 and P2X7 receptors expressed by microglial cells in neuropathic and inflammatory pain... ; and the complex actions mediated by P2X7 receptors. Some ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 47 | Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd. | ||
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Summary: , immune responses, inflammation, pain, platelet aggregation, endothelial-mediated vasodilatation, cell... subtypes expressed in oocytes or other cell types is often different from the pharmacology of P2Y-mediated... of mammalian P2Y1 receptors [34], and MRS 2179 is a potent antagonist [35]; MRS 2269 and MRS 2286 have been |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 48 | Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm | ||
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Summary: subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... -induced relaxations to the P1 receptor antagonist 8pSPT suggests that the effect of ATP may be partly mediated through... adenosine. This is suggestive of ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 49 | Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd. | ||
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Summary: 1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... on the central projections of primary afferent neurons in lamina II of the dorsal horn mediate facilitation... and specific- ity. Specific agonists and antagonists are available for the P1 ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 50 | Published: February 07, 2011 r 2011 American Chemical Society 420 dx.doi.org/10.1021/ci100375b |J. Chem. Inf. Model. 2011, 51, 420433 | ||
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Summary: receptors (2A, 2B, and 2C) are major drug targets for schizophrenia, feeding disorders, perception, depres... for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors Soo-Kyung Kim, Youyong Li, Ravinder... to highly potent and selective 5-HT2B antagonist PRX-08066 3, ... |
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Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology |
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Collection: Materials Science |
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| 51 | The Sexually Antagonistic Genes of Drosophila melanogaster | ||
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Summary: The Sexually Antagonistic Genes of Drosophila melanogaster Paolo Innocenti*, Edward H. Morrow... forces are said to be sexually antagonistic. Although the phenotypic effect of these genes has been... genetic framework, we identified a group of candidate genes experiencing sexually antagonistic selection |
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Source: Jackman, Todd - Biology Department, Villanova University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 52 | Anna Zachariou, Tencho Tenev, Lakshmi Goyal1 | ||
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Summary: . In cells destined to die this IAP-mediated inhibition of caspases is overcome by IAP-antagonists. Genetic... evi- dence indicates that IAP-antagonists are non-equiva- lent and function synergistically to promote... and Jafrac2. We ®nd that these IAP-antagonists display differential and selective binding to ... |
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Source: Steller, Hermann - Laboratory of Apoptosis and Cancer Biology, Rockefeller University |
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Collection: Biology and Medicine |
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| 53 | Corresponding author: Didier PELAPRAT Neurotensin receptor antagonist administered during cocaine withdrawal | ||
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Summary: of the drug, followed by a one- week drug-free period and a subsequent cocaine challenge (Figs. 1A, 1B, 2A, 2B... Corresponding author: Didier PELAPRAT 1 Neurotensin receptor antagonist administered during cocaine... in these phenomena. We and others have reported that SR 48692, a neurotensin receptor ... |
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Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 54 | Perspectives in Pharmacology In Vivo Gene Modification Elucidates Subtype-Specific | ||
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Summary: -selective pharmacological agents. Mice with a deletion (knockout) of the 2A-, 2B-, or 2C-gene as well as a point mutation... , and as adjuncts to general anesthesia. 2-Adrenergic receptors have been divided into three subtypes ( 2A, 2B... with these mice indicate that ... |
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Source: Kable, Joe - Center for Cognitive Neuroscience & Department of Psychology, University of Pennsylvania |
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Collection: Biology and Medicine |
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| 55 | Adenosine Receptor, Protein Kinase G, and p38 Mitogen-Activated Protein Kinase-Dependent Up-Regulation of | ||
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Summary: to inhibitory Gi/o proteins (A1 and A3 receptors), stimulatory Gs proteins (A2A and A2B receptors), as well... as Gq protein-linked PLC (A1, A2B, and A3 receptors) (Feoktistov and Biaggioni, 1997; Fred- holm et al... cells can produce AR-stimulated SERT activity in a ... |
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Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University |
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Collection: Biology and Medicine |
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| 56 | APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Dec. 2010, p. 82558258 Vol. 76, No. 24 0099-2240/10/$12.00 doi:10.1128/AEM.00499-10 | ||
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Summary: to additional screening. We identified nine antagonists (X2 to X10) and 14 agonists (A1 to A14) of LasR-mediated... , we have identified nine nonnative antagonists and 14 nonnative agonists of LasR-mediated gene... in a cell-density-dependent manner to regulate gene expression (15). Archetypal ... |
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Source: Handelsman, Jo - Department of Molecular, Cellular and Developmental Biology, Yale University |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 57 | Purinergic signalling *Geoffrey Burnstock | ||
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Summary: 2B and A3 (see Ralevic & Burnstock, 1998). All P1 adenosine receptors are typical G protein... roles in exocrine and endocrine secretion, platelet aggregation, vascular endothelial cell-mediated... that autonomic control of smooth muscle consisted of antagonistic sympathetic noradrenergic and ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 58 | PLATELET-ACTIVATING FACTOR AFFECTS NOCICEPTION IN RATS AT CEREBRAL SITES OF ACTION | ||
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Summary: platelet-activating factor (PAF) antagonists that block either plasma membrane or intracellular PAF binding... sites attenuate the late-phase nociceptive response to formalin in rats. Inasmuch as these antagonists... suggested that PAF may be an important central mediator of inflammatory-based pain. In the present study we |
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Source: Wurtman, Richard - Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT) |
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Collection: Biology and Medicine |
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| 59 | R E V I E W S NATURE REVIEWS | DRUG DISCOVERY VOLUME 2 | SEPTEMBER 2003 | 703 | ||
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Summary: of the integrin family of adhesion molecules are non-covalently-associated / heterodimers that mediate cell... efforts have been directed towards the discovery and develop- ment of integrin antagonists for clinical... not only on antagonists of integrins as promising therapeutics,but also on what the drug discovery litera |
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Source: Springer, Timothy A. - Immune Disease Institute & Department of Pathology, Harvard University |
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Collection: Biology and Medicine |
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| 60 | Neuropharmacology 40 (2001) 749760 www.elsevier.com/locate/neuropharm | ||
|
Summary: antagonist against NMDA-induced currents in Xenopus oocytes expressing NR1-1a/2A or NR1-1a/2B receptors... oocytes The rat cRNAs encoding the subunit NR1-1a and the subtypes NR2A/2B were obtained from JP... the physiologically distinct NR1-1a/2A ... |
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Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health, |
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Collection: Computer Technologies and Information Sciences ; Biology and Medicine |
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| 61 | Behavioral/Systems/Cognitive Steroid Hormones Act Transsynaptically within the | ||
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Summary: ,Spontaneousfiringrate(mean SEM).A2,B2,Cumulativefrequency distributions of firing rates (see Results for statistical... com- paredwiththenoninfusedhemisphere.A2,B2,C2... . A2, B2, The cumulative frequency ... |
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Source: Hopkins, William A. - Department of Fisheries and Wildlife Sciences, Virginia Tech |
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Collection: Environmental Sciences and Ecology ; Biology and Medicine |
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| 62 | Augmentation of antidepressive effects of SSRIs by co-administration of 5-HT2C antagonists. Augmentation of antidepressive effects of SSRIs | ||
|
Summary: Augmentation of antidepressive effects of SSRIs by co-administration of 5-HT2C antagonists. 185... Chapter 9 Augmentation of antidepressive effects of SSRIs by co-administration of 5-HT2C antagonists. #12... of antidepressant treatment by co-administration of an SSRI with a 5-HT2C antagonist. Initially we observed |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 63 | UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors | ||
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Summary: . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... gap junction-mediated buffering of K+ and metabolites, leading to prolonged activation of cells... or protracted, in the release of proinflammatory mediators, amongst which ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 64 | nature neuroscience volume 4 no 4 april 2001 417 Glutamate is the predominant excitatory neurotransmitter in | ||
|
Summary: found no effect of an mGluR1 antagonist on peripheral mGluR-mediated mechanical hyper- articles Fig. 6... GluR antagonists attenuate nociceptive scores during the for- malin test, a model used to study inflammatory pain... suggest that glutamate is a true peripheral inflammatory mediator released after tissue ... |
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Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 65 | CANCER CELL : JANUARY 2004 VOL. 5 COPYRIGHT 2004 CELL PRESS 1 Ever since the discovery of caspases as | ||
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Summary: caspases, caspase-3 and -7 (Figure 1). By doing so, it acts as a brake on caspase-mediated cellular... molecule combinatorial libraries for compounds that relieve XIAP-mediated caspase-3 inhibition. At least... . These com- pounds specifically reversed XIAP- mediated inhibition of caspase-3 and caspase-7 |
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|
Source: Wu, Hao - Department of Biochemistry, Cornell University |
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Collection: Biology and Medicine |
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| 66 | Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India | ||
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Summary: the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... nervous system. P2X3 receptor antagonists are being explored for alleviating renal colic. ATP contracts... neurons, which was mimicked by ATP and reduced by ATP antagonists [15] ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 67 | RESEARCH PAPER Role of ATP and related purines in inhibitory | ||
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Summary: , Table 3). Effects of A1, A2A, A2B and A3 receptor antagonists on relaxations to EFS, adenosine and NECA... M) and MRS1220 (10 mM), A1, A2B and A3 receptor antagonists, respectively, failed to modify these responses... MV, ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 68 | Kidney International, Vol. 64 (2003), pp. 13891397 Unusual absence of endothelium-dependent or -independent | ||
|
Summary: - sions followed: P1 receptors into A1, A2A, A2B, and A3 and P2 receptors into P2X and P2Y subtypes based... [38, 39]. Simi- larly, an inhibitory adenosine A2b receptor located on rat renal endothelial cells... of antagonists to P2X receptors and ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 69 | J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0 | ||
|
Summary: for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 ago... - nists) and depression (galanin receptor antagonists). The A2A=D2, A2A=D3 and A2A=mGluR5 heteromers... of high affinity 3H-5-HT binding sites and D2 antagonist binding sites, respectively in membrane prepara |
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Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 70 | Long-acting Opioid Antagonists Disrupt Receptor Signaling and Produce Noncompetitive Effects by Activating c-Jun | ||
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Summary: as an antagonist for KOR-mediated signal transduction (6, 8, 10). For example norBNI has been shown to block... Long-acting Opioid Antagonists Disrupt Receptor Signaling and Produce Noncompetitive Effects... (KOR) antagonists having very long durations of action in vivo despite binding non-covalently in vitro |
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|
Source: Bruchas, Michael R. - Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 71 | PharmacologyBiochemistry&Behavior,Vol.33, pp. 273-279. PergamonPressplc, 1989.Printedin the U.S.A. 0091-3057/89$3.00 + .00 The Effects of Selective Dopamine | ||
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Summary: with inter- mediate to high doses of the D2 antagonist produced significant place preferences. Recently... .S.A. 0091-3057/89$3.00 + .00 The Effects of Selective Dopamine D1 or D2 Receptor Antagonists... ability of the dopamine D1 antagonist, SCH 23390 (0.01, 0.1, 1.0, 2.0 mg/kg) or the D2 ... |
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|
Source: Beninger, Richard J. - Department of Psychology, Queen's University (Kingston) |
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Collection: Biology and Medicine |
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| 72 | doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol | ||
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Summary: -selective antagonists used were DPCPX (A1 selective; Ki 0.34.0 nM), ZM-241385 (A2a selective; Ki 0.5 nM), MRS-1754 (A2b... -241385 (0.03 M), the A2b-selective an- tagonist MRS-1754 (0.08 M), or the A3-selec- tive antagonist ... |
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Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh |
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Collection: Biology and Medicine |
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| 73 | Multiple Limbic Regions Mediate the Disruption of Prepulse Inhibition Produced in Rats by the Noncompetitive NMDA | ||
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Summary: . The neuroanatomical substrates mediating the PPI-disruptive effects of noncompetitive NMDA antagonists are unknown... indicate that multiple limbic forebrain regions mediate the ability of noncompetitive NMDA antagonists... . The neuroanatomical substrates mediating the PPI-disruptive ... |
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|
Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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Collection: Biology and Medicine |
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| 74 | Open Access Available online http://arthritis-research.com/content/8/4/R114 | ||
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Summary: -lymphocyte function with tumour necrosis factor antagonists Haïfa Hamdi1*, Xavier Mariette2*, Véronique Godot1, Karin... understood. We evaluated the effect of the TNF antagonists infliximab (Ifx), adalimumab (Ada) and etanercept... treated with TNF antagonists and with the in vitro addition of TNF ... |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 75 | Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal Neurons | ||
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Summary: equally by competitive antagonists. If the two forms of inhibitory conductance are mediated by separate... Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal... of Medicine, Los Angeles, California 90095 A tonic inhibitory conductance mediated by GABAA receptors |
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|
Source: Journal Neuroscience -- Rapid Communications |
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Collection: Biology and Medicine |
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| 76 | International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors | ||
|
Summary: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 V. Agonists and antagonists... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291 A. Chemical structure of agonist and antagonist ligands... of selective agonists ... |
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Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 77 | A. Specific Aims Presynaptic terminals are key sites for neural integration every bit as complex as their postsynaptic targets and | ||
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Summary: and Ca2+ -synaptotagmin show a mutually antagonistic competition for interaction with the SNARE complex... . We seek to demonstrate that, because G competes with Ca2+ -synaptotagmin binding, GPCR- mediated... the antagonistic interaction between G and Ca2+ -synaptotagmin at SNARE complexes. We will perform |
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Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago |
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Collection: Biology and Medicine |
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| 78 | NMDA Receptor Hypofunction Leads to Generalized and Persistent Aberrant c Oscillations Independent of | ||
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Summary: increased the power of c oscillations all over the recorded cortical areas (Fig. 3A2,B2; N = 6 rats). 3... receptor (NMDAr) antagonists, induce cognitive impairment and aggravate schizophrenia symptoms... ) electrocorticogram (ECoG). This study investigated whether NMDAr ... |
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|
Source: Ecole Polytechnique, Centre de mathématiques |
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Collection: Mathematics |
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| 79 | Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes | ||
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Summary: Michelob_x is the missing inhibitor of apoptosis protein antagonist in mosquito genomes Lei Zhou1... of extensive sequence divergence, no orthologue was identified for the reaper/grim-like IAP antagonist genes... identified michelob_x(mx), a gene not predicted by the genome project, as the missing IAP antagonist |
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|
Source: Severson, David - Department of Biological Sciences, University of Notre Dame |
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Collection: Biology and Medicine |
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| 80 | vol. 162, no. 2 the american naturalist august 2003 Coevolution in Temporally Variable Environments | ||
|
Summary: and p2 are given by T 1 p p , (A2a)1,T 1,0 ( )1 c T 1 p p , (A2b)2,T 2,0 tp0 1 bt where... ; Kapan 2001; Thompson et al. 2002) or by selection that may be antagonistic at certain points in time... - tualistic and antagonistic selection have considered only spatial variation. This work ... |
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|
Source: Gomulkiewicz, Richard - School of Biological Sciences, Washington State University; Nuismer, Scott L. - Department of Biological Sciences, University of Idaho |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology ; Mathematics |
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| 81 | The Journal of Neuroscience, December 1991, f f(12): 39303939 Opiate Withdrawal-induced Hyperactivity of Locus Coeruleus | ||
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Summary: -induced Hyperactivity of Locus Coeruleus Neurons Is Substantially Mediated by Augmented Excitatory Amino Acid Input... of the opiate antagonist naloxone (0.1 mg/kg, i.v.) robustly increased the activity of LC neurons. Local... of kynurenate, a broad- spectrum antagonist of excitatory amino acids (EAAs), sub- stantially but ... |
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Source: Aston-Jones, Gary - Department of Neurosciences, Medical University of South Carolina |
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Collection: Biology and Medicine |
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| 82 | Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit in Brain | ||
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Summary: Corticotropin-Releasing Factor-1 Receptor Activation Mediates Nicotine Withdrawal-Induced Deficit... that blockade of corticotropin-releasing factor (CRF) receptors with a nonspecific CRF1/CRF2 receptor antagonist... , the nicotinic receptor antagonist mecamylamine elevated the brain reward thresholds of the nicotine- dependent |
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|
Source: Príncipe, José Carlos - Computational NeuroEngineering Laboratory, University of Florida |
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Collection: Engineering ; Computer Technologies and Information Sciences |
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| 83 | ELSEVIER Neuroscience Letters 175 (1994) 166--170 NHROSClENCE | ||
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Summary: activity at the a2B- adrenergic receptor [9], in addition to its well-described action at al... , who used a larger number of antagonists, and con- cluded that NE sensitization is mediated through... mechanical threshold. In the presence of the ~2-adrenergic ... |
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|
Source: Guo, Ming - Brain Research Institute, University of California at Los Angeles |
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Collection: Biology and Medicine |
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| 84 | Summary and conclusions Summary and Conclusions | ||
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Summary: inhibition in one molecule (e.g. #12;Chapter 10 202 venlafaxine) or serotonin receptor antagonists that also... investigated for their use in the clinic (e.g. substance P antagonists, corticosteroid (releasing factor... ) antagonists and the herbal preparation St. John Worth), but these fall beyond the scope of this thesis. By ... |
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|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 85 | Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure in Endotoxemic Mice | ||
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Summary: Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure... (TxA2) may mediate decreases of renal blood flow (RBF) and/or GFR associated with LPS- induced sepsis... or a selective TP receptor antagonist (SQ29,548), would alleviate LPS-induced renal vasoconstriction and ARF |
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|
Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg |
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Collection: Biology and Medicine |
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| 86 | Molecular Psychiatry (2001) 6, 615617 2001 Nature Publishing Group All rights reserved 1359-4184/01 $15.00 | ||
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Summary: pain mediator, and that inhibitors of glu- tamate release, glutamate receptors, or inhibitors... and neuropathic pain states, since antagonists of mGluR1 and 5 reduce hyp- eralgesia following peripheral... , and that these receptors might mediate a component of inflammatory hyperal- gesia. As predicted, the expression of mGluR5 |
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|
Source: Gereau, Robert W. IV - Basic Research Division, Pain Center & Department of Anesthesiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 87 | Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies Augmentation of SSRI effects on serotonin by 5- | ||
|
Summary: antagonists are observed during basal conditions, this receptor is only mediating an effect on #12;Chapter 4... (2):83-91. Slattery DA, Desrayaud S, Cryan JF (2005) GABAB receptor antagonist-mediated antidepressant- like behavior... Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic ... |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 88 | Structure based prediction of subtype-selectivity for adenosine receptor antagonists | ||
|
Summary: )phenylxanthines: development and character- ization of adenosine A2B receptor antagonists and a new radioligand with sub... -deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor. Bioorg. Med. ... |
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|
Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 89 | Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum | ||
|
Summary: neuromodulator that binds to at least four known G-protein- coupled receptors in the brain (A1, A2A, A2B, and A3... adenosinergic system, and to characterize potential target sites where A2AR and mGluR5 antagonists could mediate... be mediated, pre-embedding electron ... |
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|
Source: Hall, Randy A - Department of Pharmacology, Emory University |
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Collection: Biology and Medicine |
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| 90 | Allosteric Modulation of 2-Adrenergic Receptor by Zn2 GAYATHRI SWAMINATH, JACQUELINE STEENHUIS, BRIAN KOBILKA, and TAE WEON LEE | ||
|
Summary: function in vivo. The 2-adrenergic receptor ( 2AR) mediates adrenergic responses in both the central... and Bmax values for the antagonist dihydroalprenolol (DHA). These results demonstrate that Zn2... previously (Kobilka, 1995). Membrane Binding Assays. Antagonist binding assays were done with membranes |
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Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University |
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Collection: Biology and Medicine |
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| 91 | oo26-895x196/o3o54o-o7$3.oo/o Copyright by The American Society for Pharmacology and Experimental Therapeutics | ||
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Summary: ; Accepted November 28, 1995 SUMMARY Whole-cell recordings were used to study the antagonist phar- macology... with a Kb of 6 p.M while inhibiting AMPA receptors with a Kb of >100 p.M. The remaining antagonists showed... competitive antagonists block native AMPA and kainate receptors with approximately similar potencies, which |
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|
Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis |
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Collection: Biology and Medicine |
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| 92 | Vas deferens A model used to establish sympathetic cotransmission | ||
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Summary: release via A2A receptors in the epididymal portion and via A2B receptors in the prostatic portion... receptors in the epididymal portion and adenosine A2B receptors in the prostatic portion of the rat vas... , although P- and Q-type channels also ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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Collection: Biology and Medicine |
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| 93 | Genetica 116: 179188, 2002. 2002 Kluwer Academic Publishers. Printed in the Netherlands. | ||
|
Summary: The evolution of hybrid infertility: perpetual coevolution between gender-specific and sexually antagonistic... of experimental research from Drosophila melanogaster that demonstrate that sexually antagonistic fitness... states that the expression of sexually antagonistic genes leads to a `gender-load' in each sex |
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|
Source: Rice, William - Department of Ecology, Evolution, and Marine Biology, University of California at Santa Barbara |
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Collection: Environmental Sciences and Ecology |
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| 94 | TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6 | ||
|
Summary: , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... 58261 Gs : cAMP A2B Large intestine, bladder NECA Enprofylline Gs : cAMP A3 Lung, liver, brain, testis... of purine-mediated signalling has ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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|
Collection: Biology and Medicine |
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| 95 | Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets | ||
|
Summary: was assessed by measuring the median platelet volume (MPV). The P2Y1 receptor antagonist MRS 2179 (1.06 À 10... antagonist AR-C69931MX significantly inhibited (at 10s, P ¼ 0.009; 15 s, P ¼ 0.001 and 30 s, P ¼ 0.015) ADP... -induced PSC. The P2X1 receptor antagonist TNP-ATP had no significant effect on ADP- or ADP þ ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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|
Collection: Biology and Medicine |
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| 96 | For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133 | ||
|
Summary: proliferation is mediated by A2A and A2B receptors, and some of the mitogenic effects are mediated via... (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... - stration that ... |
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|
Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London |
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|
Collection: Biology and Medicine |
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| 97 | Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies Augmentation of antidepressant effects of SSRIs by | ||
|
Summary: . Slattery, S. Desrayaud, and J. F. Cryan. GABA(B) receptor antagonist-mediated antidepressant- like behavior... Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies 205... Chapter 8 Augmentation of antidepressant effects of SSRIs by GABAB antagonists: mechanistic studies #12 |
|||
|
Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution, |
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Collection: Biology and Medicine ; Environmental Sciences and Ecology |
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| 98 | proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS GPCR 3D homology models for ligand | ||
|
Summary: 3, (no sufficient data for A2b subtype), as well as to select AA2AR antagonists ver- sus AA2AR... structure of AA2AR in selecting known antagonists from decoys, as well as from antagonists for other... Wiley-Liss, Inc. Key words: adenosine receptor; GPCR structure; ... |
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|
Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego |
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Collection: Biology and Medicine |
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| 99 | PLEASE SCROLL DOWN FOR ARTICLE This article was downloaded by: [Thangapandian, Sundarapandian] | ||
|
Summary: and are themselves modulated upon the effects of histamine [79]. Histamine was discovered as a mediator... . Histamine mediates its function through four receptor subtypes namely, H1, H2, H3 and H4 [10... to specific agonists and antagonists and by their molecular weight [1214]. Each receptor subtype is expressed |
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|
Source: Lee, Keun Woo - Department of Biochemistry, Gyeongsang National University |
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Collection: Biotechnology ; Biology and Medicine |
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| 100 | CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate | ||
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Summary: synapses this may be mediated by endocannabinoids. We evaluated whether the selective cannabinoid type 1... (CB1) receptor antagonists SR 141716 or AM 251 could modify induction of epileptiform activity... reduced by CB1 receptor antagonists, SR 141716 or AM 251. Minimal effects on epileptiform activity were |
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|
Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison |
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|
Collection: Biology and Medicine |
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