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Sample search results for: a2b receptor based

Page:   2  3  4  5 
 
1 In this thesis a combined approach is described to investigate the constitutive activity of G protein protein-coupled receptors (GPCRs) using human adenosine A2B receptors and to
 

Summary:  selected based on an adenosine A2B receptor model using the structure of bovine rhodopsin as a template... receptor. Comparison of the two A2B receptor models ...

  

Source: van den Brink, Jeroen - Leiden Institute of Physics, Universiteit Leiden

 

Collection: Physics

 
2 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... are positively coupled to adenylate cy- clase through Gs. The human A2B receptor has also been observed to couple... - ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
3 Agonist-induced polarized trafficking and surface expression of the adenosine 2b receptor in intestinal epithelial cells: role of SNARE proteins
 

Summary:  July 15, 2004; doi:10.1152/ ajpgi.00164.2004.--Adenosine, acting through the A2b receptor, in- duces... in the recruitment of the A2b receptor to the plasma membrane. In this study, we examined domain specificity... in the ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
4 The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
 

Summary:  endogenous P2Y receptors in addition to the P1 adenosine receptors A2A and A2B, which might complicate... are influenced by a physical interaction between GPR80/GPR99 and endogenous P2Y or A2B receptors, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
5 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  of the first indications of intramembrane receptor­receptor interactions based on neuropeptide induced changes... to filter incoming signals to one receptor based on the state of the target cell and the activity of other... 's disease (PD) based on the A2A=D2 ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
6 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as well... Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance STEVEN C... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
7 Purine and pyrimidine receptors G. Burnstock
 

Summary:  by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B and A3, have been cloned and charac- ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
8 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... ]. The human A2B receptor has also been observed to couple through Gq/11 to regulate phospholipase C activity... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
9 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... inhibited, whereas A2 receptors potentiated synthesis of cAMP. In primary cultures of rat astrocytes, A2B... ]; in others, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
10 Shape-Selective Recognition and Self-Assembly of mm-Scale Components
 

Summary:  on chirality. The pairs of receptors (2a/2b and 3a/3b) and ligands (4a/4b and 5a/5b) were enantiomeric (Figure... encounter than did the receptors 2a/2b; in the system comprising 3 and 5, no mismatched complexes were... them. ...

  

Source: Prentiss, Mara - Department of Physics, Harvard University

 

Collection: Physics

 
11 Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking*
 

Summary:  constructs were kindly provided by Ken Minneman (Emory University School of Medicine). 2A-, 2B-, and 2C... Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking... inhibitory signaling in the brain via stimula- tion of both GABAA ...

  

Source: Teissére, Jeremy Alden - Biology Department, Muhlenberg College

 

Collection: Biology and Medicine

 
12 Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking*
 

Summary:  by Ken Minneman (Emory University School of Medicine). 2A-, 2B-, and 2C-adrenergic receptor constructs... Hetero-oligomerization between GABAA and GABAB Receptors Regulates GABAB Receptor Trafficking... inhibitory signaling in the brain via stimula- tion of both GABAA ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
13 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... 58261 Gs : cAMP A2B Large intestine, bladder NECA Enprofylline Gs : cAMP A3 Lung, liver, brain, testis... examining ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
14 doi:10.1152/ajpgi.00147.2006 291:605-610, 2006. First published May 4, 2006;Am J Physiol Gastrointest Liver Physiol
 

Summary:  50: 870­877, 1996. 23. Murthy KS, McHenry L, Grider JR, and Makhlouf GM. Adenosine A1 and A2b... ). Current understanding of G protein coupling of S1P recep- tors is based on receptor expression studies... marker together with siRNA for S1P1 or S1P2 receptors were ...

  

Source: Hu, Wen-Hui - Department of Physiology, Virginia Commonwealth University

 

Collection: Biology and Medicine

 
15 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... receptor subtypes based on Northern blot and in situ hybridiza- tion studies [Collo et al., 1996] have been... . Further subclassification of ATP ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
16 Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
 

Summary:  that NR1/2A/2B triheteromeric receptors are present in vivo in forebrain neurons (Sheng et al., 1994... of inhibition. hal-00139989,version1-4Apr2007 #12;10 Inhibition of triheteromeric NR1/2A/2B receptors... that the maximal ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
17 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... Publishers Ltd. Purinergic Receptors and Pain Geoffrey Burnstock* Autonomic Neuroscience Centre, Royal Free... , release and ectoenzymatic breakdown and of the current classification of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
18 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  depression A2A Brain, heart, lungs, spleen Facilitates neurotransmission; smooth muscle relaxation A2B Large... the peripheral and central nervous systems4 . Separate membrane receptors for adenosine (ADO) and ATP were... identified in 1978 and called P1 and P2 receptors, respectively5 . ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 Current Topics in Medicinal Chemistry 2004, 4, 793-803 793 1568-0266/04 $45.00+.00 2004 Bentham Science Publishers Ltd.
 

Summary:  receptors and a P2Y family of G protein-coupled purinoceptors, based on studies of transduction mechanisms... The distribution of P2X receptor subtypes based on Northern blot and in situ hybridization studies [45] has been... , P. Further subclassification of ATP receptors ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
20 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... receptor classes and signal transduction systems (Bhagwat and Williams, 1997). Based on agonist efficacy... E-mediated mast cell histamine release, effects ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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21 UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors
 

Summary:  . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... specificity could not be predicted simply based on its phylogenetic position. It was shown that this receptor... UCB Pharma research ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
22 Research Signpost 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India
 

Summary:  the pig ureter, while intravesical adenosine via A2B receptors on smooth muscle [6]. ATP and adenosine... molecule. Receptors for ATP have been cloned and characterised, including seven P2X ionotropic and eight P2... Y metabotropic receptor subtypes, as well as four ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
23 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  , A2B and A3, and, in 1985, Burnstock and Kennedy proposed a basis for distinguishing between two... . The antithrombotic action of clopidogrel (Plavix), a P2Y12 receptor antagonist, has been shown to be particularly... and CURE). The role of P2X3 receptors in noci- ception and a new ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
24 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a basis... receptor antagonist, has been shown to be particularly useful in the prevention of recurrent strokes... and heart attacks in recent clinical trials. The role of P2X3 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
25 Role of delivery and trafficking of d-opioid peptide receptors in opioid
 

Summary:  of morphine tolerance (Figure 2). Based on these findings, we propose that the ratio of DOP:MOP receptors... Role of delivery and trafficking of d-opioid peptide receptors in opioid analgesia and tolerance Xu... for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Changes in the number of ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
26 International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors
 

Summary:  channel that are important in receptor-based reg- ulation of neuronal activity, the Ca2 channel of the N... 2Y1 or P2Y2 receptors can display in neurons a channel-based transduction that is highly PTX... International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian-Specific
 

Summary:  copy. Three of these pairs (pufferfish a2, b4 and r1) are composed of very similar genes that have... Early Evolution of Ionotropic GABA Receptors and Selective Regimes Acting on the Mammalian... in the central nervous system (CNS) of both invertebrates and vertebrates. Receptors of this ...

  

Source: Aris-Brosou, Stéphane - Department of Biology, University of Ottawa

 

Collection: Biology and Medicine

 
28 Probing the Mg2 Blockade Site of an
 

Summary:  . (nA) K0.5 (0 mV) (mM) Wild-type NR1a/2B 76 5.5 32.6 7 850 0.74 0.11 3.7 2.9 NR1a/2B607TAG W 82 22 32... .6 6 102 0.77 0.07 11 3.2 NR1a/2B607TAG 2-Nap 37 4 28.9 5 102 0.54 0.15 0.5 0.3 ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
29 Complex expression of natural killer receptor genes in single natural killer cells ZAHEED HUSAIN,*{{ CHESTER A. ALPER,{1 EDMOND J. YUNIS*{ &
 

Summary:  : HLA-A2, A2, B7, B7, Cw7, Cw7 and donor B: HLA-A1, A1, B8, B8, Cw7, Cw7) and donor C was heterozygous... but associate with DAP12 to form an activating receptor which contains an immunoreceptor tyrosine-based... strategy based on 3k-end amplification and cDNA ...

  

Source: Alper, Chester A. - Immune Disease Institute, Harvard University

 

Collection: Biology and Medicine

 
30 JournalofPhysiology The GABAA receptor constitutes a major inhibitory force
 

Summary:  concentrations (>100 mM, 0.6%) of ethanol are known to potentiate a2b1 and a2b1g2 subunit-containing receptors... JournalofPhysiology The GABAA receptor constitutes a major inhibitory force in the central nervous... , the ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
31 NMDA receptor subunits: function and pharmacology Pierre Paoletti and Jacques Neyton
 

Summary:  "efficacy" on NR1/2A/2B and NR1/2A/2C triheteromeric receptors 2B>>2A 2C 2D - partial antagonist ifenprodil... selectivity limitations (R)-AP5 NR2-ABD 0.3 0.5 1.6 3.7 2A 2B>2C 2D (R)-AP7 NR2-ABD 0.5 4.0 6.0 17 ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
32 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... to the Gi/o family of G proteins inhibiting cyclic AMP (cAMP) production, whereas A2A and A2B stimulate c... , D-60439, Frankfurt am Main, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
33 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... Signaling The Periphery Adenosine A1, A2A, A2B, and A3 receptors (ARs) are all present at peripheral sites... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
34 Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation
 

Summary:  ,23­25 and it is currently recognised that there are four subtypes of P1 receptors (A1, A2A, A2B and A3), seven subtypes of P... inflammatory response (vi) Sensory phenotype: decreased pain threshold107­111 A2B (i) Immunological phenotype... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
35 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... Neuropharmacology 43 (2002) 1313­1323 www.elsevier.com/locate/neuropharm P2 receptors in the murine... . The localization of P2Y1, P2Y2, P2Y4, P2X1 and P2X2 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
36 Academic Year 20052006 Biologie Molculaire et Cellulaire (BMC)
 

Summary:  . #12;DNA Cofactor TGFß TßRII TßRI early endosome Nucleus 1 2a 2b AP2 P P P P P Smad4 dynamin clathrin P... in animal as well as plant cells. Signalling in mammalian cells is based on a great diversity of receptor... and signalling of RSTKs based on the ...

  

Source: Gaude, Thierry - Département de Biologie, Ecole Normale Supérieure de Lyon

 

Collection: Biology and Medicine

 
37 Purinergic signalling *Geoffrey Burnstock
 

Summary:  2B and A3 (see Ralevic & Burnstock, 1998). All P1 adenosine receptors are typical G protein... /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... resistance for the next 20 years. In the early 1990s, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
38 The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1
 

Summary:  receptors is also thought to be a re-entrant loop based on the pattern of accessibility from both sides... structure for glu- tamate receptors based on the size of chemically cross- linked NMDA receptor protein... above that multiple subtypes exist within the AMPA and NMDA ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
39 Dual Palmitoylation of NR2 Subunits Regulates NMDA Receptor Trafficking
 

Summary:  Palmitoylation (A) GODZ increases palmitoylation of NMDA receptors on the NR2A/2B subunit Cys cluster II region... ) Palmitoylation of the NMDA receptor on the NR2A/2B subunit Cys cluster I ([I] palm-NR2) ensures proper ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
40 Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate
 

Summary:  protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate in urological... receptors'. Discovery of the trophic ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine


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41 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  REVIEW P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock... protein- coupled) receptors. In this article we consider the dual role of ATP in regulation of vascular... - lular nucleotides and their cardiovascular P2 receptors are now entering the phase of clinical

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
42 2C-Adrenergic Receptors Exhibit Enhanced Surface Expression and Signaling upon Association with
 

Summary:  (Emory University School of Medicine, Atlanta, GA). 2A-, 2B-, and 2C-Adrenergic receptor constructs were... 2C-Adrenergic Receptors Exhibit Enhanced Surface Expression and Signaling upon Association with 2... -Adrenergic Receptors Steven C. Prinster,1 Tomas G. ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
43 BENZODIAZEPINE-MEDIATED REGULATION OF a1, a2, b13 AND g2 GABAA RECEPTOR SUBUNIT PROTEINS IN THE RAT BRAIN HIPPOCAMPUS AND
 

Summary:  BENZODIAZEPINE-MEDIATED REGULATION OF a1, a2, b1­3 AND g2 GABAA RECEPTOR SUBUNIT PROTEINS... GABAA receptor subunit proteins (a1, a2, b1­3 and g2). This relationship was investigated after... receptor ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
44 Modified Receptor Internalization upon Co-expression of 5-HT1B Receptor and 5-HT2B Agnes Janoshazi*, Maud Deraet*, Jacques Callebert, Vincent Setola, Silke Guenther, Bruno
 

Summary:  al., 2003), an idea supported by the efficacy of 5-HT1B receptor agonist-based antimigraine therapy... proteins of the mouse 5-HT2B and 5-HT1B receptors were generated by PCR-based sub-cloning. The receptor... with different combination of receptor expression insured ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
45 Structure based prediction of subtype-selectivity for adenosine receptor antagonists
 

Summary:  into the structural basis of ligand subtype selectivity within the family of adenosine receptors (AR: A1, A2A, A2B... ) of ligand and decoy sets were similar. 2.2. Homology modeling of A1, A2B and A3 adenosine receptor ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
46 SPECIAL ISSUE Glycine receptors: recent insights into their
 

Summary:  a stoichiometry of 3a : 2b (reviewed in Laube et al. 2002). A recent study of recombinant GlyRs using co... . and Kristiansen U. (2004) Functional characterisation of human glycine receptors in a fluorescence-based high... fluorescent protein-based assay for ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
47 Perspectives in Pharmacology In Vivo Gene Modification Elucidates Subtype-Specific
 

Summary:  , and as adjuncts to general anesthesia. 2-Adrenergic receptors have been divided into three subtypes ( 2A, 2B... -selective pharmacological agents. Mice with a deletion (knockout) of the 2A-, 2B-, or 2C-gene as well as a point mutation... in the ...

  

Source: Kable, Joe - Center for Cognitive Neuroscience & Department of Psychology, University of Pennsylvania

 

Collection: Biology and Medicine

 
48 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 53:281291 (2001)
 

Summary:  -4), histamine (H1), serotonin (5-HT3) or adenosine (A1 and A2B) receptors [Lambrecht et al., 1992, 2000; Boyer... -phosphonate based agonists, ,-meATP and ,-meATP. One drawback to the use of PPADS as an antago- nist at P2 receptors... of a Series of PPADS Analogs at ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 Special issue: Allosterism and Collateral Efficacy Conformational complexity of
 

Summary:  ) Chimeric a2,b2-adrenergic receptors: delineation of domains involved in effector coupling and ligand... -protein-coupled receptors Brian K. Kobilka1 and Xavier Deupi2 1 Stanford University School of Medicine, 157 Beckman Center... -protein-coupled receptors (GPCRs) ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
50 Cellular/Molecular Galantamine Activates Muscle-Type Nicotinic Acetylcholine
 

Summary:  b8 B k b k d A2B . (Scheme 1) According to Scheme 1, the closed, unliganded receptor (C) binds two... in the emergence of a new nonconducting state (A2B); the preva- lence of this state, but not the duration, depended... .g., ...

  

Source: Steinbach, Joe Henry - Washington University Pain Center & Department of Anesthesiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
51 Noradrenergic Regulation of GABAergic Inhibition of Main Olfactory Bulb Mitral Cells Varies as a Function of Concentration and Receptor Subtype
 

Summary:  the enhancement decreased at higher concentrations ( 30 M); all IPSCs were blocked by 10 M gabazine (A2). B... as a Function of Concentration and Receptor Subtype Qiang Nai,1 Hong-Wei Dong,1 Abdallah Hayar,2 Christiane... olfactory bulb mitral cells varies as a function of concentration and ...

  

Source: Hayar, Abdallah - Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences

 

Collection: Biology and Medicine

 
52 470 nature neuroscience volume 1 no 6 october 1998 In the cerebral cortex, extrinsic and intrinsic excitatory
 

Summary:  illustrated in Fig. 6a2. (b) O-LM interneuron illustrated in Fig. 6a3. a b Time (s) APrate(Hz) ATPA I(pA) V... receptors has dis- inhibitory effects on pyramidal neurons19. This hypothesis is based on the observation... of ionotropic receptors, namely NMDA, AMPA and ...

  

Source: Cossart, Rosa - Institut de Neurobiologie de la Méditerranée, Inserm

 

Collection: Biology and Medicine

 
53 Dynamic Complexes of 2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role of Gravin*
 

Summary:  with separate cell lysates. FIG. 2. Association of -adrenergic receptors with protein phosphatase 2A, 2B... Dynamic Complexes of 2-Adrenergic Receptors with Protein Kinases and Phosphatases and the Role... -8661 Signals mediated by G-protein-linked receptors display ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
54 Heterodimerization with 2-Adrenergic Receptors Promotes Surface Expression and Functional Activity of 1D-Adrenergic
 

Summary:  , Japan). HA-tagged 2A-, 2B-, and 2C-AR cDNAs were kindly provided by Lee Limbird (Vanderbilt University... receptors that might traffic 1D-AR to the plasma membrane, we used a luminometer- based surface expression... Heterodimerization with 2-Adrenergic Receptors ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
55 Endocytosis and Intracellular Trafficking of Human Natural Killer Cell Receptors
 

Summary:  Endocytosis and Intracellular Trafficking of Human Natural Killer Cell Receptors Madhan Masilamani1... Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious... of signals from a broad array of activation and inhibitory receptors. Key to generating the input level

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
56 Critical ReviewsTM in Neurobiology, 16(3)187224 [2004] 0892-0915/04 $20.00 2004 by Begell House, Inc. 187
 

Summary:  to each other than to NMDA receptors, based on sequence homology. Nonetheless, there are important... , Inc. 187 Glutamate Receptor Gating Kevin Erreger,¹ Philip E. Chen,² David J.A. Wyllie,² & Stephen F... 30322-3090; kerrege@emory.edu ABSTRACT: Ionotropic glutamate receptors (iGluRs) mediate the vast

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
57 ( )A.A. Roberts, C.K. KelloggrDeelopmental Brain Research 119 2000 2132 GABA receptor subtypes that differ in subunit combina-A
 

Summary:  RNAs across rat brain regions. Relative levels of a1, a2, b1, b2, g2L, and g2S subunitA Z . Z . Z .m... of these experiments demonstrate regional heterogeneity of zolpidem binding sites, and a1, a2, b1, b2, g2S and g2L m... , values expressed indicate the mean value ...

  

Source: Kellogg, Carol K. - Department of Brain and Cognitive Sciences, University of Rochester

 

Collection: Biology and Medicine

 
58 JOURNAL OF VIROLOGY, Sept. 1995, p. 58695874 Vol. 69, No. 9 0022-538X/95/$04.00 0
 

Summary:  E5 Transforming Protein and the Endogenous Receptor for Platelet-Derived Growth Factor in Mouse C127... a stable complex with the endogenous platelet-derived growth factor (PDGF) receptor in rodent and bovine... fibro- blasts, resulting in sustained receptor activation and cell transformation. We report here

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
59 Cell, Vol. 100, 693702, March 17, 2000, Copyright 2000 by Cell Press A Novel Family of Mammalian Taste Receptors
 

Summary:  Taste Receptors 699 Figure 6. Many T2Rs Are Coexpressed in the Same Taste Receptor Cell Mixtures of (a... ) 2, (b) 5, or (c) 10 T2R probes hybridized to only very few more cells than detected by any... Taste Receptors Kinnamon et al., 1988; Gilbertson et al., 1992). ...

  

Source: Zuker, Charles - Department of Biochemistry and Molecular Biophysics, Columbia University

 

Collection: Biology and Medicine

 
60 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165­205, 2004 Dopamine Receptor... The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling... properties that contribute to the definition of the receptor class, although some differences among ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine


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61 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  -terminus and an intracellular C- terminus. The architecture of P2Y receptors was studied by structural comparison based... P2 receptor web: Complexity and fine-tuning Cinzia Volonté a,, Susanna Amadio a , Nadia D... Street, London NW3 2PF, UK Abstract The present review offers a new perspective on a family of ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
62 Channel Opening by Anesthetics and GABA Induces Similar Changes in the GABAA Receptor M2 Segment
 

Summary:  sub- units assembled around the central channel (14). A common in vivo subunit stoichiometry is 2a:2b... -subunits with evidence supporting a stoichi- ometry of 2a:3b (17­19) and of 3a:2b (20,21). Each subunit has an ;200 amino... Channel Opening by Anesthetics and ...

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collection: Biology and Medicine

 
63 The Mutant Growth Hormone-Releasing Hormone (GHRH) Receptor of the Little Mouse Does Not
 

Summary:  . As expected (based on the binding data), cells expressing the little mouse GHRH receptor did not accumulate c... to a higher negative charge in the human receptor (six more negative charges are expected, based... The Mutant Growth Hormone-Releasing Hormone (GHRH) Receptor of the Little ...

  

Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

 

Collection: Biology and Medicine

 
64 ABBREVIATIONS: NMDA, N-methyl-D-aspartic acid; ACPD, 1-aminocyclopentane-1 ,3-dicarboxylic acid; AMPA,a-amino-3-hydroxy-5-methyli-soxazole-4-propionic acid; BAPTA, 1 ,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; DMSO, dimethylsulfoxide; DNQX, 6
 

Summary:  : NMDA receptor (NR)1 A/2A, 29 nM; NR1 A/2B, 300 nM; NR1A/2C, 120 nM; NR1A/2D, 1500 nM. Measurement of EC... :1 mixtures of cRNA (NR1A plus NR2A, -2B, -2C, or -2D; -2, 5, or 20 ng of RNA encoding each receptor subunit... ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
65 Purinergic Signaling and Vascular Cell Proliferation and Death Geoffrey Burnstock
 

Summary:  established.1,2 P1 receptors for adenosine, of which four subtypes (A1, A2A, A2B, and A3) have been identified... muscle cells via A2B receptors.26 Later, it was demonstrated that adenosine, acting through ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
66 The potent pharmacological effects of opiates have been recognized by humans since ancient times. Today,
 

Summary:  exposure and are prominent examples of neural plasticity2,3. The NMDA receptor has a well-established role... plasticity. Indeed, the past ten years have seen an explosion of evidence to indicate that the NMDA receptor... interacts with NMDA receptors such that activation of the mu opioid receptor results in ...

  

Source: Barr, Gordon A. - Department of Psychology, Hunter College, City University of New York

 

Collection: Biology and Medicine

 
67 Membrane Associated Non-receptors and Morphogen Gradients
 

Summary:  )c (0 x 1) (12) with the boundary conditions x = 0 : a t = 0 a x - [h0a(2 - b) - f0b] - [¯h1Za(2 z... Membrane Associated Non-receptors and Morphogen Gradients A.D. Lander, Department of Developmental... of morphogen gradient formation to include reversible binding of morphogens (ligands) with membrane ...

  

Source: Wan, Frederic Yui-Ming - Department of Mathematics, University of California, Irvine

 

Collection: Mathematics

 
68 a-Conotoxins as selective probes for nicotinic acetylcholine receptor subclasses
 

Summary:  of these receptors takes the form (a)2(b)3, but different a and b subunits can be involved in creating one receptor... , blocking was observed against a2b4 and a7 receptors, but BuIA showed limited activity ...

  

Source: Janes, Bob - School of Biological and Chemical Sciences, Queen Mary, University of London

 

Collection: Biology and Medicine

 
69 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... 241385, KW 6002 GS1cAMP A2B Large intestine, bladder NECA (nonselective) Enprofylline, MRE2029- F20, MRS... subtype ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
70 TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3, BUT NOT a2, a4, a5, a6, b1 OR g2 GABAA RECEPTOR SUBUNIT
 

Summary:  with unknown stoichiometry, though it is probably composed of 2a, 2b and a g (or d) subunit.2,9,39 Multiple... in a1 and b3, but not a2, b1 or g2, subunit protein in the same brain regions.11 Quantitative... TEMPORAL AND REGIONAL REGULATION OF a1, b2 AND b3, BUT NOT ...

  

Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo

 

Collection: Biology and Medicine

 
71 J Physiol 563.2 (2005) pp 345358 345 Subunit-specific gating controls rat NR1/NR2A
 

Summary:  is relative to the rate for the NR2B subunit. %diff = 100 × (2A­2B)/2B. The log likelihood for global fits... /kon. Percentage difference is relative to the rate for the NR2B subunit. %diff = 100 × (2A­2B)/2B. predictions... receptor subunits ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
72 The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not
 

Summary:  The membrane proximal disulfides of the EGF receptor extracellular domain are required for high... affinity binding and signal transduction but do not play a role in the localization of the receptor... Available online 13 May 2006 Abstract The EGF receptor is a transmembrane receptor tyrosine kinase

  

Source: Pike, Linda J. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
73 The birth and postnatal development of purinergic signalling G. Burnstock,1
 

Summary:  ),Svenningssonetal.(1995), Sebastiao&Ribeiro(1996),Svenningssonetal.(1997a,b,2000),Huangetal. (2005) A2B,A3Unknown P2... ;Table1(Continued) TissuePurinoceptorsMainfunctionalroleReferences OligodendrogliaA1,A2A,A2B,A3... .(2001),Matuteetal. (2007) ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
74 Appendix Chapter 8 8.1 Summary
 

Summary:  pharmacological profiles. The design of new 5-HT7 receptor agonists was based on a pilot study on the limited... no affinity for the 5-HT7 receptor at all. Apparently, the initial pharmacophore model, based on a limited... located at the binding site of the receptor. The correlation ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
75 Minireview: Neuronal Steroid Hormone Receptors: They're Not Just for Hormones Anymore
 

Summary:  Minireview: Neuronal Steroid Hormone Receptors: They're Not Just for Hormones Anymore JEFFREY D... , by interac- tion with intracellular steroid hormone receptors acting as reg- ulators of transcription... . These intracellular steroid hormone receptors have often been considered to be activated solely by cognate hormone

  

Source: Blaustein, Jeffrey D. - Center for Neuroendocrine Studies, University of Massachusetts at Amherst

 

Collection: Biology and Medicine

 
76 Copyright C Blackwell Munksgaard 2002 Traffic 2002; 3: 866877
 

Summary:  -9219 Constitutive Activation and Endocytosis of the Complement Factor 5a Receptor: Evidence for Multiple Activated... Conformations of a G Protein-Coupled Receptor Jennifer L. Whistler1, *, Basil O. Gerber4 , Elaine C. Meng2... . Whistler, shooz2@itsa.ucsf.edu Serpentine receptors relay hormonal or sensory stimuli to ...

  

Source: Bourne, Henry - Department of Cellular and Molecular Pharmacology, University of California at San Francisco

 

Collection: Biology and Medicine

 
77 Identification of Binding Domains of the Growth Hormone-Releasing
 

Summary:  Identification of Binding Domains of the Growth Hormone-Releasing Hormone Receptor by Analysis... of Mutant and Chimeric Receptor Proteins Venita I. DeAlmeida and Kelly E. Mayo Department of Biochemistry... and activation of the GHRH receptor, which belongs to the family of G protein- coupled receptors. The ...

  

Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University

 

Collection: Biology and Medicine

 
78 Revised November 2003 Xenobiotic Receptors in Fishes
 

Summary:  Revised November 2003 Xenobiotic Receptors in Fishes: Structural and Functional Diversity... -289-3242 Fax: 508-457-2134 Email: mhahn@whoi.edu #12;Xenobiotic receptors in fish 2 Summary Many xenobiotic... xenobiotic responses in mammals: basic-helix-loop-helix/Per-ARNT-Sim (bHLH-PAS) proteins, nuclear receptors

  

Source: Hahn, Mark E. - Biology Department, Woods Hole Oceanographic Institution

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
79 Neuron, Vol. 48, 977985, December 22, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.neuron.2005.11.030 Photoinactivation of Native AMPA Receptors
 

Summary:  .neuron.2005.11.030 Photoinactivation of Native AMPA Receptors Reveals Their Real-Time Trafficking Hillel... , San Francisco San Francisco, California 94143 Summary AMPA receptors mediate the majority of the fast... trafficking of AMPA receptors into and out of the postsynaptic mem- brane underlies changes in synaptic

  

Source: Vosshall, Leslie - L:aboratory of Neurogenetics and Behavior, Rockefeller University

 

Collection: Biology and Medicine

 
80 Robust, Bistable, BMP Dependent Patterning of the Drosophila Blastoderm Embryo
 

Summary:  : Receptor interactions and positive feedback 7 4.1 Receptor role in the formation and interpretation... of the extracellular gradient 7 4.2 Receptor binding (Case 1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8... 4.3 Receptor-mediated degradation (Case 2) . . . . . . . . . . . . . . . . . . . . ...

  

Source: Othmer, Hans - School of Mathematics, University of Minnesota

 

Collection: Mathematics


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81 Neuropharmacology of alcohol addiction V Vengeliene, A Bilbao, A Molander and R Spanagel
 

Summary:  oxide; NPY, neuropeptide Y; NR1, NMDA receptor subunit 1; NR2A­D, NMDA receptor subunits 2A, 2B, 2C... , 1999). Furthermore, alcohol concentrations lower than 100 mM are known to potentiate only a2b4, a4b4, ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
82 Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system
 

Summary:  and calculated from the others based on the principle of microscopic equilibrium. The concentration of receptor... of receptor levels within a given population. This fact is un- avoidable when working in a cell-based system... July 27, 2007) Scatchard analysis of the binding of EGF to its ...

  

Source: Pike, Linda J. - Department of Biochemistry and Molecular Biophysics, Washington University in St. Louis

 

Collection: Biology and Medicine

 
83 D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties*
 

Summary:  D2/D3 Dopamine Receptor Heterodimers Exhibit Unique Functional Properties* Received for publication... for heterodimerization has recently been provided for dopamine D1 and adenosine A1 receptors as well as for dopamine D2... and somatostatin SSTR5 recep- tors. In this paper, we have studied the possibility that D2 and D3 ...

  

Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
84 Bulletin of Mathematical Biology (2007) 69: 3354 DOI 10.1007/s11538-006-9152-2
 

Summary:  x 1) (12) with the boundary conditions x = 0 : a t = 0 a x - [h0a(2 - b) - f0b] - ¯h1 Za 2 z - c... Membrane-Associated Non-Receptors and Morphogen Gradients A.D. Landera , Q. Nieb , F.Y.M. Wanb... that allows for reversible binding of morphogens (aka ligands) with signaling ...

  

Source: Wan, Frederic Yui-Ming - Department of Mathematics, University of California, Irvine

 

Collection: Mathematics

 
85 Bulletin of Mathematical Biology (2006) DOI 10.1007/s11538-006-9152-2
 

Summary:  conditions x = 0 : a t = 0 a x - [h0a(2 - b) - f0b] - ¯h1 Za 2 z - c - f1 Zc + 0 (13) x = 1 : a = 0 (14) all... -Associated Non-Receptors and Morphogen Gradients A.D. Landera , Q. Nieb , F.Y.M. Wanb, a Department... ligands) with signaling receptors, degradation of bound mor- phogens and ...

  

Source: Nie, Qing - Department of Mathematics, University of California, Irvine

 

Collection: Mathematics

 
86 Neuropharmacology 40 (2001) 749760 www.elsevier.com/locate/neuropharm
 

Summary:  antagonist against NMDA-induced currents in Xenopus oocytes expressing NR1-1a/2A or NR1-1a/2B receptors... oocytes The rat cRNAs encoding the subunit NR1-1a and the subtypes NR2A/2B were obtained from JP... the physiologically distinct NR1-1a/2A ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
87 ARTICLE Communicated by Florian Luisier Bayes-Optimal Chemotaxis
 

Summary:  to the magnitudes of the two gradient steepnesses: P(a|B1, B2) = 0 d1 0 d2 P(a)P(|1|)P(|2|)P(a|1|, a|2| B1, B2... of receptor binding, leading to a constantly fluctuating binding pattern across the cell's array of receptors... of receptors in both one and two ...

  

Source: Dayan, Peter - Gatsby Computational Neuroscience Unit, University College London

 

Collection: Biology and Medicine

 
88 Ligand Stabilization of the 2 Adrenergic Receptor: Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy
 

Summary:  Articles Ligand Stabilization of the 2 Adrenergic Receptor: Effect of DTT on Receptor Conformation... : Treatment of the 2 adrenergic receptor with the reducing agent dithiothreitol (DTT) is known to abolish... ligand binding to the receptor. Interestingly, the loss of binding can be prevented by preoccupation

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
89 Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors
 

Summary:  receptors is based mainly on effects of ETA-specific antagonists. The contribution of ETB... Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation... : interactions with ETA receptors Armin Just, Andrea J. M. Olson, and William J. Arendshorst Department of Cell

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
90 Enhancement of the surface expression of G protein-coupled receptors
 

Summary:  Enhancement of the surface expression of G protein-coupled receptors Jill H. Dunham and Randy A... 30322, USA G protein-coupled receptors (GPCRs) mediate physio- logical responses to a diverse array... , including addition/ deletion of receptor sequences, co-expression with interacting proteins, and treatment

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
91 research>>research>> Prof. Philip Lazarovici
 

Summary:  of anti-metastatic peptidomimetic lead compounds based on specific integrin-receptor antagonism; (iii... ) Development of a diagnostic kit based on nerve growth factor receptor, TrkA, activity for carcinoma staging... based on human umbilical cord blood neural stem cell for cell therapy ...

  

Source: Lelkes, Peter I. - School of Biomedical Engineering, Drexel University

 

Collection: Materials Science ; Biology and Medicine

 
92 Mini Review The platelet-derived growth factor receptor as a target of the
 

Summary:  Mini Review The platelet-derived growth factor û receptor as a target of the bovine papillomavirus... the platelet-derived growth factor û receptor in a ligand-independent fashion. The E5 protein induces receptor... activation by forming a stable complex with the receptor, thereby inducing ...

  

Source: DiMaio, Daniel - Departments of Genetics & Molecular Biophysics and Biochemistry, Yale University

 

Collection: Biology and Medicine

 
93 C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes
 

Summary:  loops [10]. Homology models of the melatonin receptors are based on the crystal structure of rhodopsin... C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization... effects via G-protein-coupled melatonin receptors, MT1 and MT2 [2, 3]; however, it can modulate quinone

  

Source: Pollock, John Archie - Department of Biological Sciences, Duquesne University

 

Collection: Biology and Medicine

 
94 REVIEW PAPER GnRH and GnRH receptors: distribution, function
 

Summary:  RH-R subfami- lies (a1, a2, b1 and b2) corresponding to a set of three conserved amino acids (PEY, SDP, PPS... was not uniformly supported. In another scheme, two main groups of GnRH receptors were identified, based on the size... SUBFAMILIES Flanagan et al. (2007) proposed two main ...

  

Source: Fernald, Russell - Department of Biology, Stanford University

 

Collection: Biology and Medicine

 
95 Brain Research 932 (2002) 9198 www.elsevier.com/locate/bres
 

Summary:  subtype as compared to the 5-HT and changes were again used for quantitative purposes. In each2A 2B 5-HT... cascade which suggests the presence of a 5-HT receptor subtype; however, this is based on vertebrate 5-HT... similarities to the vertebrate receptor the ...

  

Source: Cooper, Robin L. - Department of Biology, University of Kentucky

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
96 Synthetic Mimics of Small Mammalian Cell Surface Receptors Siwarutt Boonyarattanakalin, Scott E. Martin, Sheryl A. Dykstra, and
 

Summary:  mediated by the higher affinity DNP-based receptors 2-5, the magnitude and kinetics of delivery of a green... -associated DNP and NBD-based receptors, this compound (10) binds proteins in cell culture media and can... Synthetic Mimics of Small Mammalian Cell Surface Receptors Siwarutt ...

  

Source: Peterson, Blake R. - Department of Medicinal Chemistry, University of Kansas

 

Collection: Chemistry

 
97 Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
 

Summary:  , as discussed below, ifenprodil not only affects NR1/NR2B receptors but also triheteromeric NR1/2A/2B receptors... antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
98 Associate editor: Neve Sensitization of adenylate cyclase by Gai/o-coupled receptorsB
 

Summary:  Associate editor: Neve Sensitization of adenylate cyclase by Gai/o-coupled receptorsB Val J. Wattsa... , and Research Service, Veterans Affairs Medical Center, Portland, OR 97239, USA Abstract Activation of receptors... , persistent activation of Gai/o-coupled receptors produces a paradoxical enhancement of adenylate cyclase

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
99 YOUNG INVESTIGATOR PERSPECTIVES Nuclear Receptor Coactivators in Neuroendocrine Function
 

Summary:  of transcriptional activators that can be divided into subfamilies based on phylogenetic analysis. Receptors... YOUNG INVESTIGATOR PERSPECTIVES Nuclear Receptor Coactivators in Neuroendocrine Function M. J... of Massachusetts, Amherst, MA, USA. Key words: steroid hormones, reproductive behaviour, SRC-1, oestrogen ...

  

Source: Tetel, Marc J. - Department of Biological Sciences, Wellesley College

 

Collection: Biology and Medicine

 
100 Annu. Rev. Neurosci. 2003. 26:50963 doi: 10.1146/annurev.neuro.26.010302.081139
 

Summary:  the possibility that the adenosine A2b receptor may fulfill such a function is of great interest. Certain... pharmacological experiments sug- gest that the A2b receptor is required for netrin-1-promoted outgrowth of dorsal... ...

  

Source: Cloutier, Jean-François - Montreal Neurological Institute

 

Collection: Biology and Medicine


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