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Sample search results for: a-inhibited guanine nucleotide-exchange

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1 Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange*
 

Summary:  Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange* Received... by Rho GTPase-activating proteins (GAPs).1 Guanine nucleotide exchange factors (GEFs) rapidly convert... critical for nucleotide ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
2 Identification of TRIO-GEFD1 chemical inhibitors using the Yeast Exchange Anne Blangy, *Nathalie Bouquier, *Ccile Gauthier-Rouvire, *Susanne
 

Summary:  -methyl coumarin CPEPD: 1,1'-(2-chloro-1,4-phenylene)bis(1H-pyrrole-2,5-dione) GEF: Guanine nucleotide exchange... )bis(1H-pyrrole-2,5-dione) RhoGEF: Rho GTPase guanine nucleotide exchange factor #12;3 Acknowledgements... cascades. Rho GTPase activation is catalyzed by ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
3 Molecular Biology of the Cell Vol. 16, 12131222, March 2005
 

Summary:  ., Chabre, M., Cherfils, J., and Antonny, B. (1998). A glutamic finger in the guanine nucleotide exchange... of alterna- tively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines... ). The membrane-tethering protein p115 interacts ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
4 Combinatorial Chemistry & High Throughput Screening, 2003, 6, 79-99 1 1386-2073/03 $41.00+.00 2003 Bentham Science Publishers Ltd.
 

Summary:  to each subfamily. Guanine nucleotide exchange factors (GEFs) activate GTPases, while GTPase activating... between GDP-bound "off" state and GTP-bound "on" states. Guanine nucleotide exchange factors (GEFs... the guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
5 Principal Investigator/Program Director (Last, first, middle): Sondek, John E. PHS 398/2590 (Rev. 09/04) Page 1 Biographical Sketch Format Page
 

Summary:  ). Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature 408, 682... , M.A., and Der, C.J. (2001). Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family... , J. and Der, C.J. (2001). Molecular basis for Rac1 ...

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill; Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine ; Mathematics

 
6 http://jbx.sagepub.com Journal of Biomolecular Screening
 

Summary:  nucleotide exchange factors (GEFs) stimulate guanine nucleotide exchange and the subsequent activation of Rho... localization to the plasma membrane and activation. Last, the guanine nucleotide exchange factors (GEFs... ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
7 AKAP-Lbc Anchors Protein Kinase A and Nucleates G 12-selective Rho-mediated Stress Fiber Formation*
 

Summary:  , Portland, Oregon 97201 Guanine nucleotide exchange factors of the Dbl family relay signals from membrane... ) and a Rho-selective guanine nucleotide exchange factor. Expression of AKAP-Lbc in fibroblasts favors... are a growing family of guanine ...

  

Source: Scott, John D. - Department of Pharmacology, University of Washington at Seattle

 

Collection: Biology and Medicine

 
8 Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF*S
 

Summary:  Real-time NMR Study of Guanine Nucleotide Exchange and Activation of RhoA by PDZ-RhoGEF*S Received... is intrinsically very slow in most GTPases but is significantly accelerated by guanine nucleotide exchange factors... GTPases, whereas guanine ...

  

Source: Ikura, Mitsuhiko - Division of Molecular and Structural Biology, University of Toronto

 

Collection: Biotechnology ; Biology and Medicine

 
9 Rho-family GTPases comprise a main branch of the Ras superfamily of small (~21 kDa) GTPases . So far,
 

Summary:  -defined GEF MEANS GO: TURNING ON RHO GTPases WITH GUANINE NUCLEOTIDE-EXCHANGE FACTORS Kent L. Rossman... * , Channing J. Der* and John Sondek*§ Abstract | Guanine nucleotide-exchange factors (GEFs) are directly... details that control the guanine nucleotide-exchange ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
10 The DH and PH Domains of Trio Coordinately Engage Rho GTPases for their Efficient Activation
 

Summary:  by the exchange of bound GDP for GTP, a process that is catalyzed by Dbl-family guanine nucleotide exchange... in engaging Rho GTPases directly for efficient guanine nucleotide exchange and support a parsimonious... stabilize cytosolic, inactive forms of the GTPases; ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
11 Cellular/Molecular cAMP Acts on Exchange Protein Activated by cAMP/cAMP-
 

Summary:  of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3... AMP-regulated guanine nucleotide exchange protein, is involved in the hormonal enhancement of synaptic transmission... isoform of cAMP-regulated ...

  

Source: Zucker, Robert S. - Department of Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine

 
12 SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC*S
 

Summary:  SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC*S Received... of Medicine, Chapel Hill, North Carolina 27599 SmgGDS is an atypical guanine nucleotide exchange factor (GEF... family guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
13 Molecular Biology of the Cell Vol. 19, 523535, February 2008
 

Summary:  , but had no impact on COPI and several Golgi markers. Surprisingly, brefeldin A­inhibited guanine... , brefeldin A­inhibited guanine nucle- otide exchange factor; COP, coat protein; ERES, ER exit sites; ERGIC... by small GTPases, which in turn are regulated by guanine ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
14 Real-time NMR Study of Three Small GTPases Reveals That
 

Summary:  -activating proteins (GAPs) and guanine nucleotide exchange factors, are affected by the presence of the fluorescent... -Ras. Guanine nucleotide exchange factor-catalyzed nucleotide exchange for both H-Ras and RhoA was ...

  

Source: Ikura, Mitsuhiko - Division of Molecular and Structural Biology, University of Toronto

 

Collection: Biotechnology ; Biology and Medicine

 
15 Summary of current research interests Cell-cell adhesion in tissue formation and survival
 

Summary:  (2003) Identification of a tight junction-associated guanine nucleotide exchange factor that activates... cells. · Molecular characterisation of a tight junction-associated oncogene, a guanine nucleotide... exchange factor for Rho GTPases, that controls ...

  

Source: Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Geosciences

 
16 Molecular Cell Short Article
 

Summary:  and II, surrounding the nucleotide-binding site. GTPase-specific guanine nucleotide exchange factors... guanine nucleotide exchange for a number of Rab family GTPases has been explored both structurally... AND DISCUSSION Overview of the Structure The ...

  

Source: Reinisch, Karin Marion - Department of Cell Biology, Yale University

 

Collection: Biology and Medicine

 
17 Crystal structure of Rac1 in complex with the guanine nucleotide
 

Summary:  Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1 David K... ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
18 Quantitative Analysis of the Effect of Phosphoinositide Interactions on the Function of Dbl Family Proteins*
 

Summary:  catalyzed by members of the Dbl family of guanine nucleotide exchange factors (GEFs). This family of GEFs... -mail: sondek@med.unc.edu. 1 The abbreviations used are: GEF, guanine nucleotide exchange factor; DH, Dbl... were fit to a one-binding site model (30). ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
19 Presynaptic Effectors Contributing to cAMP-Induced Synaptic Potentiation in Drosophila
 

Summary:  ; guanine nucleotide exchange factor; forskolin; neuromuscular junction; synaptic transmission INTRODUCTION... guanine nucleotide exchange pro- teins, BFA (Morinaga et al., 1996), applied at a con- centration of 100 M... :205­ 215. Morinaga N, Tsai C, Moss J, Vaughan ...

  

Source: Zucker, Robert S. - Department of Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine

 
20 Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation*
 

Summary:  07103 Dbl family members are guanine nucleotide exchange factors specific for Rho guanosine... -linked immunosorbent assay; GEF, guanine nucleotide exchange factor; GST, glutathione S-transferase; HA, he... for regulated guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine


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21 A Critical Role of a Cellular Membrane Traffic Protein in Poliovirus RNA Replication
 

Summary:  ]. Conversion of Arf-GDP into Arf-GTP requires the activity of guanine nucleotide exchange factors (GEFs... nucleotide exchange factor for the small cellular GTPases, Arf, is responsible for the sensitivity of virus... secretory pathway. The inactive, cytoplasmic GDP-bound form of Arf, ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
22 Role of the C-Terminal SH3 Domain and N-Terminal Tyrosine Phosphorylation in Regulation of Tim and Related Dbl-Family Proteins
 

Summary:  ReceiVed May 12, 2008 ABSTRACT: Dbl-related oncoproteins are guanine nucleotide exchange factors (GEFs... triphosphatase; Tim, transform- ing immortalized mammary; GEF, guanine nucleotide exchange factor; DH, Dbl... ). Guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
23 The Guanine Nucleotide Exchange Factors Sec2 and PRONE: Candidate Synapomorphies for the Opisthokonta and the Archaeplastida
 

Summary:  The Guanine Nucleotide Exchange Factors Sec2 and PRONE: Candidate Synapomorphies... that 2 particular types of guanine nucleotide exchange factors (GEFs, i.e., cofactors of GTPases) might... , Lord EM, Yang Z. 2006. Members of a novel class of Arabidopsis Rho ...

  

Source: Charles University in Prague, Department of Botany, Phycology Research Group

 

Collection: Biology and Medicine

 
24 NEWS AND VIEWS Pimp my cell
 

Summary:  is controlled by guanine nucleotide exchange factors (GEFs), which exchange bound GDP for GTP, and GTPase... with synthetic guanine nucleotide exchange factors. Nature 447: 596­600. News and Views P Bastiaens 2 Molecular... activity in an in vitro ...

  

Source: Lim, Wendell - Departments of Cellular and Molecular Pharmacology & Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
25 The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin
 

Summary:  The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin K. Farid Ahmad... homology (DH) domain guanine nucleotide exchange factors (GEF) which control Rho- family GTPase signaling... , Lim WA (2010) The Minimal Autoinhibited Unit of the ...

  

Source: Lim, Wendell - Departments of Cellular and Molecular Pharmacology & Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
26 (159), ra8. [DOI: 10.1126/scisignal.2001446]4Science Signaling G. Dohlman and Alan M. Jones (8 February 2011)
 

Summary:  that have been ascribed to the helical domain are to interact with the guanine nucleotide exchange factor... domain that affect nucleotide exchange in animal G protein a subunits: the guanine nucleotide... a subunit AtGPA1 has a rapid spontaneous rate of ...

  

Source: Jones, Alan M. - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
27 Gq Directly Activates p63RhoGEF and Trio via a Conserved Extension of the DH-associated PH Domain
 

Summary:  . Recently, the Dbl-family guanine nucleotide exchange factor (GEF) p63RhoGEF/GEFT has been described... ). Guanine nucleotide exchange factors (GEFs) activate G proteins by promoting the release of bound GDP... guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
28 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  surrogate peptide (KB-752).22 Each of these peptides can act as a G guanine nucleotide exchange factor (GEF... nucleotide exchange factor; FCS, fetal calf serum. doi:10.1016/j.jmb.2009.08.043 J. Mol. Biol. (2009) 393... -inde- pendent basal nucleotide-exchange rate. ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
29 PHS 398/2590 (Rev. 09/04) Page Biographical Sketch Format Page Principal Investigator/Program Director (Last, First, Middle)
 

Summary:  .L. and Der, C.J. (2001). Structural basis for Rac1 recognition by guanine nucleotide exchange factors. Nature... , a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J. Biol. Chem. 277:42964-42972. Booden... , M.A., Siderovski, D.P and Der, C.J. ...

  

Source: Elston, Timothy C. - Department of Pharmacology, University of North Carolina at Chapel Hill

 

Collection: Mathematics ; Biology and Medicine

 
30 A Molecular Redox Switch on p21ras STRUCTURAL BASIS FOR THE NITRIC OXIDE-p21ras
 

Summary:  -nitrosylation event on full- length p21ras with enhanced guanine nucleotide exchange (17). In the present in vitro... radicals induce guanine nucleotide exchange on p21ras in cells and in vitro (17­19). Therefore, we examined... for NO-induced ...

  

Source: Chait, Brian T. - Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University

 

Collection: Biology and Medicine

 
31 COMMUNICATION Tyr39 of Ran Preserves the RanGTP Gradient by
 

Summary:  nucleotide-exchange factor RCC1,4 the GTPase- activating protein (GAP) Rna1p5 and is stabilized by the Ran... and the active GTP-bound form. Ran, a Ras-like guanine nucleo- tide-binding protein, is a key regulator... formation and nuclear envelope assembly of eukaryotic cells during mitosis.3 Ran is regulated by the guanine

  

Source: Gerwert, Klaus - Fakultät für Biologie, Ruhr-Universität Bochum

 

Collection: Biology and Medicine

 
32 All cancers are characterized by an abnormal control of cell proliferation. This is caused by mutation or mis-
 

Summary:  activating mutations in guanine-nucleotide exchange factors (GEFs) or inactiva- tion of GTPase... state.Guanine-nucleotide exchange factors (GEFs) facilitate the exchange of GDP for GTP to generate... ).Activation (exchange of GDP by GTP) is promoted by guanine-nucleotide ...

  

Source: Roberts, James M. - Basic Sciences Division, Fred Hutchinson Cancer Research Center

 

Collection: Biology and Medicine

 
33 Biochem. J. (2006) 400, 563572 (Printed in Great Britain) doi:10.1042/BJ20061020 563 The Dbs PH domain contributes independently to membrane targeting and
 

Summary:  domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange... (guanine nucleotide-exchange factors) for the Rho GTPases almost invariably contain a PH (pleckstrin homo... domain. Key words: Dbl's big sister (Dbs), guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
34 Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo
 

Summary:  GTPases is promoted by guanine nucleotide exchange factors (GEFs), which promote the GDP-GTP exchange. GEF... that Rac1 and Cdc42 promote neurite outgrowth, while RhoA inhibits outgrowth (Luo, 2002). However, we have... , it is possible that imbalanced RhoA ...

  

Source: Bendlin, Barbara - Neuroscience Training Program & Wisconsin Alzheimers Disease Research Center, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
35 Structure, Vol. 12, 10791086, June, 2004, 2004 Elsevier Ltd. All rights reserved. DOI 10.1016/j.str.2004.03.021 Crystal Structure of the DH/PH Fragment
 

Summary:  , the conformationally vari-Dbl proteins are guanine nucleotide exchange factors able switch regions of the Rho GTPases... , 2003). However, in contrast to Activation is catalyzed by guanine nucleotide exchange Dbs, the crystal... of unbound Dbs is similar, though not ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
36 Molecular Biology of the Cell Vol. 19, 34883500, August 2008
 

Summary:  to a membrane allows activation by a guanine nucleotide exchange factor (GEF). Subsequent inactivation of Arf... , Golgi-specific brefeldin A resistance factor 1; GEF, guanine nucleotide exchange factor; GFP, green flu... prevents GBF1 release from membranes and led ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
37 MOLECULAR AND CELLULAR BIOLOGY, Oct. 2002, p. 68956905 Vol. 22, No. 19 0270-7306/02/$04.00 0 DOI: 10.1128/MCB.22.19.68956905.2002
 

Summary:  for modification 3 April 2002/Accepted 28 June 2002 Dbs is a Rho-specific guanine nucleotide exchange factor (Rho... is a Rho-specific guanine nucleotide exchange factor (RhoGEF) that was identified in a screen for c... , and tumorigenicity in nude mice. Since ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
38 An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg2+
 

Summary:  suggest that guanine nucleotide exchange factor may utilize this feature to generate an open conformation... ­915 BBRC #12;(GAPs) and guanine nucleotide exchange factors (GEFs) [11]. The active GTP bound form... . 263 (1988) 11792­11799. [16] A. Hall, A.J. Self, The ...

  

Source: Chen, Liqing - Department of Chemistry, University of Alabama in Huntsville

 

Collection: Chemistry ; Biotechnology

 
39 dendritic spine development The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent
 

Summary:  dendritic spine development The Rac1 guanine nucleotide exchange factor Tiam1 mediates Eph... .pnas.org/misc/reprints.shtml To order reprints, see: Notes: #12;The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor... understood. Here, we report that ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
40 Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
 

Summary:  , kinetic analysis of Cdc42 guanine-nucleotide exchange confirmed this notion. Map induced the release... mutations in Map on the Cdc42 guanine nucleotide- exchange of GTPgS35 catalyzed by 0.5 mM Map (or mutants... simultaneously main- tained a universal guanine ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine


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41 The Structural Basis for Activation of the Rab Ypt1p by the TRAPP
 

Summary:  also functions as a guanine nucleotide exchange factor (GEF) for the Rab GTPase Ypt1p (Sacher et al... ) allows us to propose a mechanism for guanine nucleotide exchange in which each subunit in the TRAPPI... role in guanine ...

  

Source: Reinisch, Karin Marion - Department of Cell Biology, Yale University

 

Collection: Biology and Medicine

 
42 Mechanism of Association and Reciprocal Activation of Two GTPases
 

Summary:  -activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Two homologous GTPases, one in the signal... -activating protein; GEF, guanine nucleotide exchange factor; GMPPNP, 59-guanylylimidodiphosphate; RNC... . Determination of Complex Formation ...

  

Source: Walter, Peter - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
43 Mechanism of Association and Reciprocal Activation of Two GTPases
 

Summary:  -activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs). Two homologous GTPases, one in the signal... -activating protein; GEF, guanine nucleotide exchange factor; GMPPNP, 59-guanylylimidodiphosphate; RNC... . Determination of Complex Formation ...

  

Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
44 MOLECULAR AND CELLULAR BIOLOGY, Mar. 1993, p. 1345-1352 0270-7306/93/031345-08$02.00/0
 

Summary:  and closely homologous genes in other eukaryotes encode guanine nucleotide exchange factors for Ras proteins... by proteins referred to as guanine nucleotide exchange factors (also referred to as guanine nucleotide... -specific ...

  

Source: Boguski, Mark S. - Center for Biomedical Informatics, Harvard University

 

Collection: Mathematics ; Biology and Medicine

 
45 Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling
 

Summary:  an essential, conserved function in the regulation of the intrinsic guanine nucleotide exchange activity... -L. Surprisingly, we found that the PH domain was dispensable for guanine nucleotide exchange activity on Cdc42... the h- Fig. 2. ITSN-L DH and DH­PH domain ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
46 www.landesbioscience.com Autophagy 17 Autophagy 7:1, 17-26; January 2011; 2011 Landes Bioscience
 

Summary:  -to-Golgi intermediate compartment; GEF, guanine nucleotide exchange factor; LAMP-1, lysosome- associated membrane... ) complexes act as guanine nucleotide exchange factors (GEFs) to activate Ypt1 in yeast35-37 and play... complex (TRAPPIII) in yeast that functions as ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
47 Structure, Vol. 12, 19551965, November, 2004, 2004 Elsevier Ltd. All rights reserved. DOI 10.1016/j.str.2004.09.003 The Crystal Structure of RhoA in Complex with the
 

Summary:  to that described in the Dbs complex (Snyder et al., 2002). Figure 2. Guanine Nucleotide Exchange Activity of Rho... . Multidomain averagingGuanine Nucleotide Exchange Assay Fluorescence spectroscopic analysis using the N... , C.J. (2001). Molecular basis for Rac1 ...

  

Source: Wlodawer, Alexander - Macromolecular Crystallography Laboratory, National Cancer Institute

 

Collection: Chemistry ; Biology and Medicine

 
48 Introduction Many metazoan cell types for example, fibroblasts or
 

Summary:  use to regulate Rho protein activity appears to be the regulation of their corresponding guanine-nucleotide-exchange... 321, 788-790. Bateman, J. and Van Vactor, D. (2001). The Trio family of guanine- nucleotide-exchange... cell line, however, activation of RhoA inhibits growth-factor- ...

  

Source: Waterman, Clare M - Laboratory of Cell and Tissue Morphodynamics, National Heart Lung and Blood Institute

 

Collection: Biology and Medicine

 
49 A R T I C L E S 756 VOLUME 11 NUMBER 8 AUGUST 2004 NATURE STRUCTURAL & MOLECULAR BIOLOGY
 

Summary:  guanine nucleotide exchange factors (GEF) for Rho family GTPases and are linked to multiple biological... produced GST-Rac in the presence of 10 mM EDTA. Radioactivity-based guanine nucleotide exchange assays... of at least five independent experiments. ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
50 Proc. Natl. Acad. Sci. USA Vol. 95, pp. 1327813283, October 1998
 

Summary:  activate MAP kinase. Rap and Ras proteins both can be activated through guanine nucleotide exchange factors... characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. Because... - and dia- cylglycerol-regulated ...

  

Source: Graybiel, Ann M. - McGovern Institute for Brain Research & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
51 Neuron, Vol. 26, 14, April, 2000, Copyright 2000 by Cell Press And thus Trio enters the picture. Originally identified asTrio Quartet in D. (melanogaster)
 

Summary:  Trio, a they also identified new mutants in Dock, an adaptor guanine nucleotide exchange factor (GEF... the active and inactive forms. The guanine nucleotide exchange factors (GEFs) help con- Trio (again pointing... , guanine ...

  

Source: Luo, Liqun - Department of Biology, Stanford University

 

Collection: Biology and Medicine

 
52 Molecular Biology of the Cell Vol. 3, 1015-1024, September 1992
 

Summary:  .M. (1991). Rasl and a putative guanine nucleotide exchange factor perform crucial steps in signaling... to actin by blocking its dissociation, while profilin catalytically promotes nucleotide exchange. Be- cause... the inhibitory effects of high concentrations of thymosinfl4 on the ...

  

Source: Pollard, Thomas D.- Department of Molecular, Cellular and Developmental Biology, Yale University

 

Collection: Biology and Medicine

 
53 The signal recognition particle (SRP) and the SRP receptor (SR) mediate the co-translational targeting of nascent pro-
 

Summary:  the N/G interface could allow regulation of nucleotide exchange by prying open the active site (`guanine... nucleotide exchange factor, the SRP GTPases have a low affinity for GDP in vitro. Moser et al.13 have... of the protein and therefore help to drive nucleotide ...

  

Source: Stroud, Robert - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
54 The signal recognition particle (SRP) and the SRP receptor (SR) mediate the co-translational targeting of nascent pro-
 

Summary:  the N/G interface could allow regulation of nucleotide exchange by prying open the active site (`guanine... nucleotide exchange factor, the SRP GTPases have a low affinity for GDP in vitro. Moser et al.13 have... of the protein and therefore help to drive nucleotide ...

  

Source: Walter, Peter - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
55 Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression
 

Summary:  ,2 Autoinhibition of the Rho guanine nucleotide exchange factor ASEF is relieved by interaction with the APC tumor... nucleotide exchange factor (RhoGEF) `APC-stimulated guanine nucleotide exchange factor' (ASEF, also called... ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
56 Z .Molecular Brain Research 48 1997 140144 Short communication
 

Summary:  Abstract Z .In rodents, the Ras-specific guanine-nucleotide exchange factor Ras-GRF is expressed... -Donini, The Ras guanine nucleotide exchange factor CDC25Mm is present at synaptic junctions, Exp. Z .Cell Res... nucleotide exchange Z .factors ...

  

Source: Vogel, Zvi - Department of Neurobiology, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
57 Molecular Biology of the Cell Vol. 18, 22442253, June 2007
 

Summary:  ). A glutamic finger in the guanine nucleotide exchange Active Arf6 Recruits ARNO GEFs to the PM Vol. 18, June... -specific guanine nucleotide exchange factor Dbs by Rac1. J. Biol. Chem. 279, 12786­12793. Cherfils, J., Menetrey, J... -domain ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
58 Histochem Cell Biol (2008) 129:129151 DOI 10.1007/s00418-007-0363-x
 

Summary:  et al. 2004). This provides further evidence for nucleotide exchange by Sec12p being responsible... nucleotide exchange on the truncated form of Sar1. Altogether results show that mem- brane insertion by the N

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
59 Biochem. J. (2008) 414, 471484 (Printed in Great Britain) doi:10.1042/BJ20080149 471 The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between
 

Summary:  by its inhibition of GEFs (guanine-nucleotide- exchange factors) that act on the small GTPases of the ARF... )hydrazone benzaldehyde; FCS, foetal calf serum; GalT, galactosyltransferase; Gb3, globotriaosylceramide; GEF, guanine-nucleotide-exchange

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
60 Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif*
 

Summary:  27599-7295 Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho... , and proliferative disorders (3). The Dbl-family of guanine nucleotide exchange factors (GEFs)5 are the largest group... , guanine ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine


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61 bacterium). Regions of the monomer are now more accessible for designing posi-
 

Summary:  of Hsp110:Hsp70 complexes that reveal a compelling picture for the mechanism of nucleotide exchange... , nucleotide exchange in Hsp70s is affected by nucleotide exchange factors (NEFs). Various Hsp70 NEFs have been... by which Hsp110s elicit ...

  

Source: Hendrickson, Wayne A. - Department of Biochemistry and Molecular Biophysics, Columbia University

 

Collection: Biology and Medicine

 
62 THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
 

Summary:  , guanine nucleotide exchange factor; GST-RBD, GST­Rhotekin Rho binding domain; MEF, mouse embryonic... by extended RhoA reactivation (Ren et al., 1999). Rho GTPases are activated by guanine nucleotide exchange... A GTPases facilitate FA formation, yet FA-associated ...

  

Source: Gardel, Margaret - Department of Physics, University of Chicago

 

Collection: Biology and Medicine ; Physics

 
63 Summary of current research interests Functional analysis of tight junctions
 

Summary:  , such as erbB-2, PCNA and cyclin D1 · Discovery of a tight junction-associated guanine nucleotide exchange

  

Source: Saunders, Mark - Benfield Hazard Research Centre, Department of Space and Climate Physics, University College London

 

Collection: Geosciences

 
64 . search engine basics . bibliometric and related methods
 

Summary:  guanine nucleotide exchange factor Sos Ras guanine nucleotide exchange factor Sos #12; 11 Recognizing

  

Source: Belew, Richard K. - Departments of Computer Science and Engineering & Cognitive Science, University of California at San Diego

 

Collection: Computer Technologies and Information Sciences

 
65 Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
 

Summary:  LETTERS Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors... : turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Rev. Mol. Cell Biol. 6, 167... , 468­475 (2002). 11. Zamanian, J. L. & Kelly, R. B. Intersectin 1L ...

  

Source: Lim, Wendell - Departments of Cellular and Molecular Pharmacology & Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
66 THEJOURNALOFCELLBIOLOGY JCB: ARTICLE
 

Summary:  , guanine nucleotide exchange factor; HOPS, homotypic fusion and vacuole protein sorting; rGdi1, recombinant... are activated by guanine nucleotide exchange fac- tors (GEFs) that eject GDP to promote GTP binding and are in... but two Vps-C/HOPS subunits: Vps39, a ...

  

Source: Fields, Stan - Department of Genome Sciences, University of Washington at Seattle

 

Collection: Biology and Medicine

 
67 587Commentary Introduction
 

Summary:  , RanBP10, can act as a microtubule-binding cytoplasmic guanine-nucleotide exchange factor for Ran (Ran... is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J. Biol. Chem. 283... are strongly dependent on its ...

  

Source: Fainzilber, Michael - Department of Biological Chemistry, Weizmann Institute of Science

 

Collection: Biology and Medicine

 
68 Supplemental Data October 2005 Developmental Cell
 

Summary:  the guanine- nucleotide exchange factor Cdc24 at sites of polarization. Embo J 21, 1565-1576. Irazoqui, J. E... of the S. cerevisiae Cdc24p guanine nucleotide exchange factor. Curr Genet 45, 257-264. Wedlich-Soldner, R... , 1062-1070. Shimada, Y., Wiget, P., Gulli, M. ...

  

Source: van Oudenaarden, Alexander - Department of Physics, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine ; Physics

 
69 Biochemistry and cell signaling taught by bacterial effectors
 

Summary:  and GDP-bound `off' states, catalyzed by gua- nine-nucleotide exchange factors (GEFs) and GTPase... in the active state following nucleotide exchange-mediated activation by its Rab1-activation domain, which... 152, 2809­2818 21 Trosky, J.E. et al. (2007) VopA ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
70 Modifications to the C-terminus of Arf1 alter cell functions and protein interactions
 

Summary:  ) in vitro nucleotide exchange, and (iii) interaction with guanine nucleotide exchange factors and GTPase... ­12). For example, the Arfs can use at least 16 different guanine nucleotide exchange factors (ArfGEFs; that each... , ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
71 Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA
 

Summary:  M-induced drastic displacement of switch I of Rab1. GDI-displacement factor | guanine nucleotide exchange factor... -bound state to the other is catalyzed by guanine nucleotide exchange factors (GEFs) and GTPase... ) The Legionella pneumophila effector protein DrrA is a ...

  

Source: National Institute of Biological Sciences, Beijing

 

Collection: Biology and Medicine

 
72 CONSTITUTIVELY ACTIVE Mutant proteins that remain
 

Summary:  act by titrating guanine nucleotide exchange factors.The specificity of a dominant-negative mutant... .Two classes of protein facilitate the switch between these two states.Guanine nucleotide exchange factors... Guanine ...

  

Source: Luo, Liqun - Department of Biology, Stanford University

 

Collection: Biology and Medicine

 
73 Rewiring Cellular Morphology Pathways With Synthetic Guanine Nucleotide Exchange Factors
 

Summary:  Rewiring Cellular Morphology Pathways With Synthetic Guanine Nucleotide Exchange Factors Brian J... - and Gbetagamma-regulated guanine- nucleotide exchange factor for Rac. Cell 108, 809-821 (2002). doi: 10... into 20 mM Tris, 50 mM NaCl, 2 mM DTT, pH 7.5 (for in vitro ...

  

Source: Lim, Wendell - Departments of Cellular and Molecular Pharmacology & Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
74 Nuclear export of proteins and RNAs Sara Nakielny and Gideon Dreyfuss*
 

Summary:  . As mammalian cells with a temperature-sensitive mutation in a guanine nucleotide exchange factor for Ran, RCCl... guanine nucleotide exchange factor (RCCI) is exclusively nuclear, while its GTPase-activating protein (Rna... , apparently because its ...

  

Source: Dreyfuss, Gideon - Department of Biochemistry and Biophysics, University of Pennsylvania

 

Collection: Biology and Medicine

 
75 Biochem. J. (2008) 414, e1e2 (Printed in Great Britain) doi:10.1042/BJ20081438 e1 Arfs and membrane lipids: sensing, generating and responding to
 

Summary:  in the membrane and opens up the Arf structure to facilitate nucleotide exchange under physiological conditions (i... exchange with liposomes of increasing curvature, i.e. smaller diameter. Optimal nucleotide exchange... nucleotide exchange at ...

  

Source: McMahon, Harvey - Laboratory of Molecular Biology, MRC

 

Collection: Biology and Medicine

 
76 Inhibition of the Mitochondrial KATP Channel by Long-chain Acyl-CoA Esters and Activation by Guanine Nucleotides*
 

Summary:  with two binding sites for gua- nine nucleotides. We also found that palmitoyl-CoA and oleoyl-CoA inhibited... - CoA inhibit mitoKATP with high potency, and this inhibition is also reversed by GTP... inhibited with K1/2 80 nM and Hill coef- ficient of 1.7. ...

  

Source: Garlid, Keith - Department of Biology, Portland State University

 

Collection: Biology and Medicine

 
77 Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation
 

Summary:  , insertion into membranes and GTP exchange. To facilitate GTP exchange, guanine nucleotide exchange factors... to undergo guanine nucleotide exchange. FLAG­Rab7 was immunopurified from HEK293T cell lysates... Disease mutations in Rab7 result in unregulated ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
78 Paternal genome effects on aging: Evidence for a role of Rasgrf1 in longevity determination?
 

Summary:  is a guanine-nucleotide exchange factor, highly expressed in the central nervous system, that induces Ras... body weight and extended lifespan of bi-maternal mice. Rasgrf1 is a neuronal guanine- nucleotide... exchange factor that induces Ras signaling in a calcium-dependent manner and ...

  

Source: de Magalhães, João Pedro - School of Biological Sciences, University of Liverpool

 

Collection: Biology and Medicine

 
79 Biochem. J. (2010) 426, 281292 (Printed in Great Britain) doi:10.1042/BJ20091351 281 Molecular mechanism of elongation factor 1A inhibition by a Legionella
 

Summary:  ), inhibition of activation by GEFs (guanine-nucleotide-exchange factors), inhibition of the membrane... , elongation factor 1A; GEF, guanine nucleotide exchange factor; GST, glutathione transferase; HEK, human... mechanism of elongation factor 1A inhibition by a ...

  

Source: van Aalten, Daan - Division of Biological Chemistry and Molecular Microbiology, University of Dundee

 

Collection: Biology and Medicine

 
80 JOURNAL OF VIROLOGY, Jan. 2007, p. 558567 Vol. 81, No. 2 0022-538X/07/$08.00 0 doi:10.1128/JVI.01820-06
 

Summary:  for guanine nucleotide exchange (23). All Arf GEFs are peripherally associated membrane proteins either... . Cher- fils, and B. Antonny. 1998. A glutamic finger in the guanine nucleotide exchange factor ARNO... of guanine-nucleotide-exchange ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine


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81 APTAMER-DERIVED PEPTIDES AS POTENT INHIBITORS OF THE ONCOGENIC RHOGEF TGAT
 

Summary:  ) 391-400" DOI : 10.1016/j.chembiol.2009.02.006 #12;2 SUMMARY Guanine nucleotide exchange factors (GEFs... by the Dbl family of Rho Guanine Nucleotide Exchange Factors (RhoGEFs), which accelerates their GDP... , including a Dbl Homology (DH) domain responsible for ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
82 NATURE |VOL 410 |1 MARCH 2001 |www.nature.com 89 letters to nature
 

Summary:  characteristic of guanine nucleotide exchange factors for the Rho family of G proteins, and two proline... antibodies were used at dilutions of 1:200. Guanine nucleotide exchange assay Small G proteins GST±RhoA, GST... 12, 1331±1343 (1994). 16. Hart, M. J. et al. ...

  

Source: Blackshaw, Seth - Department of Neuroscience, Johns Hopkins University

 

Collection: Biology and Medicine

 
83 Special issue: Membrane Dynamics Online Article: Insights into COPI coat
 

Summary:  GTPase Arf1. This is mediated by guanine nucleotide exchange factors (GEFs) that convert Arf1 to its... , C.L. and Casanova, J.E. (2000) Turning on ARF: the Sec7 family of guanine-nucleotide-exchange... -resistant guanine nucleotide exchange factor ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
84 Molecular Biology of the Cell Vol. 20, 42054215, October 1, 2009
 

Summary:  Golgi traffic. The guanine nucleotide exchange factor (GEF) or factors that activate Rab1... exchange activity on Rab1. We found that mTRAPPII stimulated the guanine nucleotide exchange activity... Rab1 but not Rab11, Rab4, or Rab7. Anti-mBet3 ...

  

Source: Lippincott-Schwartz, Jennifer - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development

 

Collection: Biology and Medicine

 
85 Epac: effectors and biological Sara S. Roscioni, Carolina R.S. Elzinga, Martina
 

Summary:  -bound state and an active GTP-bound state. Guanine nucleotide exchange factors (GEFs) stimulate the GDP... ; GEFs, guanine nucleotide exchange factors. B, Schematic representation of the domain organization... AMP-regulated guanine ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
86 Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
 

Summary:  . The exchange of GDP for GTP is promoted by guanine nucleotide exchange factors (GEFs) that include Dbl family... transformation. Results Rac1b exhibits a high intrinsic guanine nucleotide exchange activity that is not further... determined that Rac1b exhibited a ...

  

Source: Sondek, John - Departments of Pharmacology & Biochemistry and Biophysics, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
87 Induced nucleotide specificity in a GTPase Shu-ou Shan and Peter Walter
 

Summary:  the active and inactive forms is modulated by external factors, such as guanine nucleotide exchange factors... GTPases. Unlike canonical GTPases that bind guanine nucleotides tightly and require nucleotide exchange... to the requirement for ...

  

Source: Walter, Peter - Department of Biochemistry and Biophysics, University of California at San Francisco

 

Collection: Biology and Medicine

 
88 Redistribution of membrane proteins between the Golgi apparatus and endoplasmic reticulum in plants is reversible
 

Summary:  guanine nucleotide exchange factors (GEF, Mansour et al., 1999; Robineau etal., 2000). Speci®c residues

  

Source: 

 

Collection: Biology and Medicine

 
89 Available online at www.sciencedirect.com Recent mechanistic insights into eukaryotic ribosomes
 

Summary:  of GDP from eEF1A is accelerated by a guanine nucleotide exchange factor (GEF), eEF1B, which is composed... -termination complex containing RF1 or RF2 acts as a guanine nucleotide exchange factor for RF3 [62]. The mechanism... in EF-Tu for guanine ...

  

Source: Joseph, Simpson - Department of Chemistry and Biochemistry, University of California at San Diego

 

Collection: Biology and Medicine ; Chemistry

 
90 Novel Interaction between the M4 Muscarinic Acetylcholine Receptor and Elongation Factor 1A2*
 

Summary:  AChR, but not with the en- dogenous M1 mAChR. In our in vitro model, M4 dramat- ically accelerates nucleotide exchange of e... interac- tions on eEF1A2 nucleotide exchange. Next, we tested the hypothesis that the M4i3 loop behaves... . This demonstrates the ability of eEF1B to accelerate the ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
91 Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
 

Summary:  by a guanine nucleotide exchange factor (GEF; Fig. 3a, step 3), or the association of Cdc42 with PIP2 liposomes... ,2). Guanine nucleotide exchange factor (GEF) catalyzes GDP release (step 3). GTPase activating protein (GAP... . & Zheng, Y. The role of Mg2+ ...

  

Source: Kirchhausen, Tomas - Immune Disease Institute & Department of Cell Biology, Harvard University

 

Collection: Biology and Medicine

 
92 Crk Activation of JNK via C3G and R-Ras* (Received for publication, August 24, 1999, and in revised form, January 27, 2000)
 

Summary:  , at least, required for the transformation by v-Crk (4). C3G promotes the guanine nucleotide exchange... -Jun-dependent Transcription by the Guanine Nucleotide Exchange Proteins--To exclude the in- volvement of Rap1 from the C3G... -dependent activation of JNK, we ...

  

Source: Graybiel, Ann M. - McGovern Institute for Brain Research & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
93 Touch and go: guidance cues signal to the growth cone cytoskeleton
 

Summary:  understood. Now, two recent studies [55 ,56] have identified guanine nucleotide exchange factors (GEFs... regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 2001, 105... actin filament polymerization and increasing ...

  

Source: Kalil, Katherine - Department of Anatomy, University of Wisconsin at Madison; Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
94 provided as Supplementary Information (http://www.nature.com/nature). When the
 

Summary:  of a signalling complex composed of Ras, a guanine-nucleotide-exchange factor and perhaps the receptor. In PC12... (reviewedinref.5). For Ras, these results are expected. Gen- erally, a guanine-nucleotide-exchange fac- tor, Sos... are shown. GEF, guanine-nucleotide-exchange factor; PtdIns-3-OH kinase, phosphatidylinositol-3-OH ...

  

Source: Kahn, Joseph M. - Department of Electrical Engineering, Stanford University

 

Collection: Engineering

 
95 http://genomebiology.com/2002/3/3/reports/4006.1 commentreviewsreportsdepositedresearchinteractionsinformationrefereedresearch
 

Summary:  by the Dot/Icm secretion apparatus and to act as a guanine-nucleotide exchange factor for ARF1. Furthermore... domain, the common sequence between the known highly divergent ARF guanadine-nucleotide exchange factors

  

Source: Theriot, Julie - Departments of Biochemistry & Microbiology and Immunology, Stanford University

 

Collection: Biology and Medicine

 
96 GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling
 

Summary:  proposed that AtRGS1 could be a guanine-nucleotide exchange factor (GEF) and/or a GTPase... ; GEF, guanine-nucleotide exchange factor; GPCR, G protein-coupled receptor. ¶To whom correspondence... that is constitutively GTP-bound given its high spontaneous nucleotide ...

  

Source: Jones, Alan M. - Department of Biology, University of North Carolina at Chapel Hill

 

Collection: Biology and Medicine

 
97 RhoE controls myoblast alignment prior fusion through RhoA and ROCK Running title: RhoE is a regulator of myoblast fusion
 

Summary:  , GAPs: GTPase-activating proteins, GEFs: guanine nucleotide-exchange factors, GM: growth medium, MLCK... is controlled by guanine nucleotide-exchange factors (GEFs), whereas their inactivation is promoted by GTPase... GAP activation and RhoA inhibition at the onset of ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
98 Annu. Rev. Neurosci. 2003. 26:50963 doi: 10.1146/annurev.neuro.26.010302.081139
 

Summary:  nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) (Figure 2). GEFs facilitate... by the combined action of Rho GTPase­activating proteins (Rho GAPs) and Rho GTPase nucleotide exchange factors... , Rho GTPases cycle between active and inactive states through the binding of ...

  

Source: Cloutier, Jean-François - Montreal Neurological Institute

 

Collection: Biology and Medicine

 
99 Gureasko et al., Supplementary Information Supplementary Information
 

Summary:  - catalyzed nucleotide exchange for Ras coupled to lipid vesicles when fluorescently labeled mant... molecules, but only catalyzes nucleotide exchange at the catalytic site. We use a convention where "Ras... (empty allosteric site) kslow = nucleotide exchange rate ...

  

Source: Kuriyan, John - Howard Hughes Medical Institute & Departments of Chemistry & Molecular and Cell Biology, University of California at Berkeley

 

Collection: Biology and Medicine ; Chemistry

 
100 Name Katsura Asano Title Associate Professor
 

Summary:  -activating and guanine-nucleotide exchange factors in translation initiation, mediate binding to their common substrate e... , and Katsura Asano. An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation

  

Source: Kaufman, Glennis A. - Division of Biology, Kansas State University

 

Collection: Environmental Sciences and Ecology


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