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Sample search results for: a2a receptor antagonist

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1 J Neural Transm (2007) 114: 4975 DOI 10.1007/s00702-006-0589-0
 

Summary:  for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 ago... - nists) and depression (galanin receptor antagonists). The ...

  

Source: Chin-Sang, Ian - Department of Biology, Queen's University (Kingston)

 

Collection: Biology and Medicine

 
2 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Four different P1 receptor subtypes, A1, A2A, A2B, and A3, have been cloned. All are G... -protein-coupled receptors (GPCRs). At 318 amino acids in length, the A3 subtype is the shortest, while A2A is the longest... - ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
3 Stimulating electrode AMPA receptor
 

Summary:  GABAB receptor Agonist = baclofen Antagonist = phaclofen Antagonist = 2-amino-5-phosphonovaleric acid... (AP5 or APV) Antagonist = 6-cyano-7-nitro-quinoxaline- (CNQX) mGluR mGluR receptor: Agonist = 2-amino... 2,3-dione Glutamate Glu GABA NMDA AMPA Na+ Na+ & Ca++ K+ Stimulating ...

  

Source: Hasselmo, Michael - Department of Psychology & Computational Neurophysiology Laboratory, Boston University

 

Collection: Biology and Medicine

 
4 Bruce N. Cronstein, MD You Are Not Arthur Conan Doyle
 

Summary:  A2A receptors in fibrosis in tissues outside of the skin is less clear... laboratory and others indicate that adenosine A2A receptors play an important role... adenosine ...

  

Source: Wang, Da-Neng - Skirball Institute of Biomolecular Medicine & Department of Cell Biology, New York University

 

Collection: Biology and Medicine

 
5 The concept of purinergic neurotransmission was pro-posed in 1972 (REF. 1), after it was shown that adenosine
 

Summary:  to interact during locomotion71 . Specific A2A receptor antagonists are currently being investigated... disorders, highlighting specific purinergic receptor subtypes, most notably A2A , P2X4 and P2X7 ,that ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
6 Relating NMDA Receptor Function to Receptor Subunit Composition: Limitations of the Pharmacological Approach
 

Summary:  antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem... receptor field (Cull-Candy and Leszkiewicz, 2004). For this purpose, having subtype-selective antagonists... ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
7 ABSTRACT The concept of a purinergic sig-nalling system, using purine nucleotides and
 

Summary:  , cerebralischaemia, sleep apnoea, pain and inflammation32. A2A receptor antagonists are being investigated... were due to indirect action via P1 receptors. Four subtypes of P2 receptors were cloned, namely A1, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
8 Vol. 275, No. 3 Printed in U.S.A.
 

Summary:  .4, 5.1) 0.31 (2.8, 3.4) 3 3 5 3 NMDA receptor clones NR1A/2A NR1A/2B NR1N2C NR1A/2D (1 p.M glycmne... glutamate receptors expressed in Xenopus oocytes to ACEA-lOll (fig. 3). NR1A/2A receptors were most ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
9 Structure based prediction of subtype-selectivity for adenosine receptor antagonists
 

Summary:  . The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322... . Structure-based discovery of novel chemo- types for adenosine A(2A) receptor ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
10 P2 receptor web: Complexity and fine-tuning Cinzia Volont a,, Susanna Amadio a
 

Summary:  , zinc and copper and generic P2X receptor antagonists. Nevertheless, currents are relatively insensitive... ., 2002; Jacobson et al., 2004), a selective antagonist at P2 receptor versus other types of receptors... , but not a universal P2 receptor ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
11 Purinergic signalling: therapeutic potential* GEOFFREY BURNSTOCK
 

Summary:  SIGNALLING: THERAPEUTIC POTENTIAL 303 notion that A2A receptor antagonists may be useful for the treatment... receptors were cloned, namely A1, A2A, A2B and A3 and in 1985, Burnstock and Kennedy proposed a ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
12 Perspectives in Pharmacology P2 Purinergic Receptors: Modulation of Cell Function and
 

Summary:  this response. AMP gives rise to adenosine, which acti- vates the various P1 receptors (A1, A2A, A2B, A3... of available P2 receptor antagonists are relatively weak and only mar- ginally selective for one P2 receptor... and Knutsen, 2001). ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
13 REVIEW ARTICLE Chemokine receptors and other G protein-coupled receptors
 

Summary:  .6 Angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 2008; 322... of invertebrate rhodopsin, b1-adrenergic and b2-adrenergic receptors and the A2A-adenosine ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
14 Progress in Neurobiology 70 (2003) 387407 Kainate receptors and synaptic transmission
 

Summary:  of selective antagonists that allow for isolation of kainate receptor-mediated currents (Paternain et al., 1995... for kainate receptor analysis APV Competitive antagonist of NMDA receptors ATPA Agonist selective for GLUK5... antagonist of AMPA and kainate ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
15 Current Pharmaceutical Design, 2009, 15, 000-000 1 1381-6128/09 $55.00+.00 2009 Bentham Science Publishers Ltd.
 

Summary:  1, A2A, A2B, and A3 (see [53]). All P1 adenosine receptors couple to G proteins and, in common... and specific- ity. Specific agonists and antagonists are available for the P1 receptor subtypes [54]. P2X... receptors can be distinguished with ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
16 Enhancement of the surface expression of G protein-coupled receptors
 

Summary:  receptors [49], Usp4, which increases plasma membrane expression of adenosine A2A receptors [50], ATBP50... surface level of the A2a receptor. Mol. Pharmacol. 69, 1083­1094 51 Wruck, C.J. et al. (2005) ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
17 The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor
 

Summary:  endogenous P2Y receptors in addition to the P1 adenosine receptors A2A and A2B, which might complicate... antagonist. It is in fact a D2 receptor and b2-adrenoceptor agonist. In the section `GABA receptors' on p... . 574, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
18 Purine and pyrimidine receptors G. Burnstock
 

Summary:  by ectonucleotidases. Four subtypes have been identified, A1, A2A, A2B and A3 receptors. P2 receptors are activated... different P1 receptor subtypes, A1, A2A, A2B and A3, have been cloned and charac- ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
19 Purine and pyrimidine receptors G. Burnstock
 

Summary:  , shortly after, the A3 subtype was identified [21]. Four different P1 receptor subtypes, A1, A2A, A2B and A... transmembrane domain. Polymorphisms have been observed in the A1 and the A2A receptors. P1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
20 Heterodimerization of G Protein-Coupled Receptors: Specificity and Functional Significance
 

Summary:  GPCRs (A1, A2A, A2b, and A3), whereas ATP activates P2X receptors, which are ion channels, as well... . (2003) Adenosine A2A-dopamine D2 receptor- receptor heteromerization: qualitative and quantitative... ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine


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21 ABBREVIATIONS: NMDA, N-methyl-D-aspartic acid; ACPD, 1-aminocyclopentane-1 ,3-dicarboxylic acid; AMPA,a-amino-3-hydroxy-5-methyli-soxazole-4-propionic acid; BAPTA, 1 ,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; DMSO, dimethylsulfoxide; DNQX, 6
 

Summary:  : NMDA receptor (NR)1 A/2A, 29 nM; NR1 A/2B, 300 nM; NR1A/2C, 120 nM; NR1A/2D, 1500 nM. Measurement of EC... the receptors expressed by rat brain poly(AY RNA, NR1A/2A and NR1AJ2B responses showed progressive run-down upon... ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
22 pubs.acs.org/jmcPublished on Web 01/22/2010r 2010 American Chemical Society J. Med. Chem. 2010, 53, 17991809 1799
 

Summary:  recently of human A2A adenosine receptor35 (A2AAR) in com- plex with antagonist 1 (ZM24138536 ), open... and 3a) of A2A Adenosine Receptor Figure 1. Binding of known antagonists into ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
23 P2 receptors in cardiovascular regulation and disease David Erlinge & Geoffrey Burnstock
 

Summary:  phase hyperaemia mediated via A2A receptors on smooth muscle cells. Red blood cells as regulators... . However, drugs with antagonistic effects on P2Y12 receptors that reach the peripheral circulation (AZD6140... phase of the reactive hyperaemia as has been shown by ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
24 JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. 24, No. 3, pp. 165205, 2004
 

Summary:  or antagonists at the phospholipase C-coupled receptor, whereas the drug SKF83959 has little efficacy... antagonist ligand of the Gq- and phospholipase C-coupled D1-like receptor. D1-Like Receptor Regulation of Ion... JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION Vol. ...

  

Source: Neve, Kim A. - Department of Behavioral Neuroscience, Oregon Health and Science University

 

Collection: Biology and Medicine

 
25 Rational discovery of novel nuclear hormone receptor antagonists
 

Summary:  Rational discovery of novel nuclear hormone receptor antagonists Matthieu Schapira* , Bruce M... , with the exception of the human estrogen receptor- , the lack of antagonist-bound ``inactive'' receptor structures... receptor- by using informa- tion derived from ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
26 UCB Pharma research day--25 October 2007 `Glia-neuron interactions and purinergic receptors
 

Summary:  . In the early 1990s, P1 and P2 receptors were cloned and characterised: four P1 receptor subtypes (A1, A2A, A2B... and antagonists of old and new P2 receptors'. Extracellular purine and pyrimidine nucleotides are ubiquitous... ) and P2X1 ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
27 doi:10.1152/ajpcell.00025.2006 291:254-265, 2006. First published Mar 29, 2006;Am J Physiol Cell Physiol
 

Summary:  of this process are known. Western blot analysis established that all four aden- osine receptors (A1, A2a, A2b... membrane of the umbrella cell layer, whereas A2a, A2b, and A3 receptors were localized intracellularly... ...

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collection: Biology and Medicine

 
28 Novel Treatment for Stroke, Brain Trauma, Alzheimer's Disease and
 

Summary:  cell death, unlike previous non-specific NMDA receptor antagonists Principal Inventor(s): Dr. Yu Tian... survival. This explains why previous non-specific NMDA receptor antagonists have failed in all clinical... while co-administering glycine (the co-agonist of NMDA receptors) and an ...

  

Source: Michelson, David G. - Department of Electrical and Computer Engineering, University of British Columbia

 

Collection: Engineering

 
29 Spinal neurons are sensitized following stimuli that activate nociceptors. This central sensitization is
 

Summary:  ), a 5-HT2A/2C receptor agonist; and MK-212, a 5-HT2C receptor agonist. The 5-HT receptor antagonists... used were WAY-100635, a 5-HT1A receptor antagonist; normethyl clozapine, a 5-HT2A/2C receptor... antagonist; and ...

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
30 INTERACTION BETWEEN ATP AND NERVE GROWTH FACTOR SIGNALLING IN THE SURVIVAL AND NEURITIC OUTGROWTH FROM
 

Summary:  for adenosine (A1, A2A, A2B and A3 subtypes, all G-protein-coupled) and P2 receptors for ATP (P2X ionotropic... ., 2001. Activation of protein kinase A and atypical protein kinase C by A2A adenosine receptors... AbstractöIn a ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
31 TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001 http://tips.trends.com 0165-6147/01/$ see front matter 2001 Elsevier Science Ltd. All rights reserved. PII: S0165-6147(00)01643-6
 

Summary:  , four subtypes of adenosine (P1) receptors were cloned [A1 , A2A , A2B and A3 (Ref. a)]. P2X receptor... but the two receptors can be distinguished with antagonists (i.e. suramin blocks P2Y2 receptors and Reactive... adenine ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
32 Pharmacology of Pain edited by Pierre Beaulieu, David Lussier, Frank Porreca, and Anthony H. Dickenson
 

Summary:  as purines [26,128] (see Table I). Four subtypes of P1 receptors have been cloned--A1, A2A, A2B, and A3 (see... receptors lead to suppression of pain signaling, while A2A receptors lead to pain ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
33 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  bound to the antagonist cyanopindolol24 ; the human A2A adenosine receptor bound to the antagonist ZM... --the human 2 adrenergic receptor (2AR), the avian 1AR and the human A2A ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
34 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  energies (kcal/mol) to the human A2A adenosine receptor of the eight antagonists listed in Table 2 compared... of a human A2A adenosine receptor bound to an antagonist. Science 322, ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
35 The behavioral pharmacology of hallucinogens William E. Fantegrossi a,
 

Summary:  antagonists are available for relevant serotonergic receptors, the majority of which have now been cloned... induce this effect [18­25], and that 5-HT2 receptor antagonists selectively block the HTR [26... phenethylamines and tryptamines could be blocked by 5-HT2 receptor ...

  

Source: Howell, Leonard L. - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
36 BI-DIRECTIONAL MODULATION OF BED NUCLEUS OF STRIA TERMINALIS NEURONS BY 5-HT: MOLECULAR EXPRESSION AND
 

Summary:  receptor antagonist, WAY 100635 (200 nM) evoked only a monophasic inward current (Fig. 2A) with a reversal... is not a selective 5-HT2 receptor antagonist Fig. 2. Monophasic inward current to 5-HT unmasked by the 5-HT1A... . Consequently, we next examined the ability of more selective 5-HT ...

  

Source: Rainnie, Donald "Tig" - Yerkes National Primate Research Center, Emory University

 

Collection: Biology and Medicine

 
37 The past two years have seen remarkable advances in the structural biology of G-protein-coupled receptors (GPCRs). Highlights have
 

Summary:  ; the human A2A adenosine receptor bound to the antagonist ZM241385 (ref. 25); and bovine rhodopsin26... . The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an ...

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collection: Biology and Medicine

 
38 Neuropharmacology 43 (2002) 13131323 www.elsevier.com/locate/neuropharm
 

Summary:  subdivisions of P1 recep- tors, into A1, A2A, A2B and A3 and of P2 receptors into P2X and P2Y families... responses were inhibited by the P2Y1-selective antagonist MRS 2179, and suramin. P2Y1 receptors were... antagonists, immunostain- ing and in ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
39 Purinergic signalling *Geoffrey Burnstock
 

Summary:  /ADP, respectively, was proposed (Burnstock, 1978). Four subtypes of P1 receptors have been cloned, namely A1, A2A, A... . Adenosine, via A2A receptors, has a protective effect in a rat model of Parkinson's disease, perhaps... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
40 Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co-localization with the metabotropic glutamate receptor 5 in the striatum
 

Summary:  Title Page Adenosine A2A receptor in the monkey basal ganglia: ultrastructural localization and co... ; Accepted: Aug 12, 2011 #12;Abstract The adenosine A2A receptor (A2AR) is a potential drug target... neuromodulator that ...

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine


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41 2001 Wiley-Liss, Inc. DRUG DEVELOPMENT RESEARCH 52:110 (2001)
 

Summary:  were cloned, namely, A1, A2A, A2B, and A3 [Ralevic and Burnstock, 1998]. P2X Receptor Family P2X... ,-methylene ATP (,-meATP), and there are now very potent selective antagonists for this receptor... , Frelin C. 1998. ATP derivatives are ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
42 Provided for non-commercial research and educational use only. Not for reproduction, distribution or commercial use.
 

Summary:  crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 2008;Oct 2 [Epub ahead... pathway for diffusible ligands. The structure of an engi- neered human A2A adenosine receptor ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
43 BRADSHAW 978-0-12-374145-5 00388 Multi-Pass Receptors
 

Summary:  - neered human A2A adenosine receptor in complex with the subtype specific antagonist ZM241385 provides... a number of additional surprises. The ligand binds to the A2A ade- nosine receptor in an ...

  

Source: Sakmar, Thomas P. - Laboratory of Molecular Biology and Biochemistry, Rockefeller University

 

Collection: Biology and Medicine

 
44 Neuropharmacology of alcohol addiction V Vengeliene, A Bilbao, A Molander and R Spanagel
 

Summary:  , the response to the glutamate/NMDA receptor (NMDAR) antagonist ketamine was altered, as opposed to the response... -preferring counterpart lines (McBride and Li, 1998). In agreement, 5-HT3 receptor antagonists were shown to suppress... opioids are crucial for mediating alcohol- induced reward. The opioid ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine

 
45 BIOLOGY COLLOQUIUM Monday, October 31, 2011
 

Summary:  weeks (flare effect) followed by an overall antagonist effect resulting from receptor down... and can lead to increased side-effects such as lower bone density. A full receptor antagonist is expected... on a campaign to discover small molecule antagonists of the GnRH ...

  

Source: Heller, Barbara - Department of Applied Mathematics, Illinois Institute of Technology

 

Collection: Mathematics

 
46 *National Institute of Child Health and Human
 

Summary:  - prises the A1 , A2A , A2B and A3 adenosine receptors, which were identified by convergent data from... and locomotor depressant effects85 . The most well-known signal transduction mecha- nism for A2A receptors... is the ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
47 Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists
 

Summary:  Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists Mathew V... and unbinding kinetics of GABAA receptor agonists and antagonists in outside-out patches from rat hippocampal... after each experiment. GABAA receptor agonists and ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
48 J Physiol 586.14 (2008) pp 33073312 3307 TOPICAL REVIEW
 

Summary:  in purinergic signalling 3309 purines and pyrimidines have been identified: P1 adenosine receptors (A1, A2A, A2B... of antagonists to P2X4 and P2X7 receptors expressed by microglial cells in neuropathic and inflammatory pain... .) inflammatory pain (see Jarvis, 2003). ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
49 Purinoceptors on Neuroglia Alexei Verkhrasky & Oleg A. Krishtal &
 

Summary:  to several families of Gi and Go proteins. Four types of adenosine receptors (A1, A2A, A2B and A3... , induced [Ca2+ ]i elevation via activation of A2A receptors [77]. In cultured mouse astrocytes adenosine... -dependent ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
50 For personal use only. Not to be reproduced or distributed without permission from Prous Science. Drug News Perspect 16(3), April 2003 2003 Prous Science CCC: 02140934/2003 133
 

Summary:  (A 1, A2A, A2B, A3), are activated by adenosine. 1 There are two distinct families of receptors... ,38 Mice lacking the adeno- sine A2A receptor were found to have an increase in heart rate and high blood... pressure (as well ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
51 Myoclonus and Paroxysmal Dyskinesias, Advances in Neurology, Vol. 99, edited by S.
 

Summary:  acid receptor antagonist strychnine (a glycine receptor antagonist) or bicuculline (a GABAA receptor... ,B,respectively). Similarly, the high-affinity 5-HT2 receptor antagonist mianserin failed to block synchronous motor activity... (Fig. 7B; n = ...

  

Source: Manitoba, University of - Spinal Cord Research Centre

 

Collection: Biology and Medicine

 
52 This article was originally published in the Encyclopedia of Neuroscience published by Elsevier, and the attached copy is provided by Elsevier for the
 

Summary:  Encyclopedia of Neuroscience (2009), vol. 1, pp. 105-113 Author's personal copy #12;A2A (P1) receptors... and to hypertrophic and hyperplasic responses. P2Y receptor antagonists have been pro- posed as potential... primary afferents. There is an urgent need for ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
53 Nonpeptide antagonists of neuropeptide receptors: Tools for research and therapy
 

Summary:  Nonpeptide antagonists of neuropeptide receptors: Tools for research and therapy Catalina Betancur... @adr.st-antoine.inserm.fr Running title: Nonpeptide antagonists of peptide receptors Key words: nonpeptide antagonist, peptide... the discovery of the first nonpeptide ...

  

Source: Ecole Polytechnique, Centre de mathématiques

 

Collection: Mathematics

 
54 Ligand Stabilization of the 2 Adrenergic Receptor: Effect of DTT on Receptor Conformation Monitored by Circular Dichroism and Fluorescence Spectroscopy
 

Summary:  . The change in emission spectrum correlated with a loss in the ability of the receptor to bind antagonist... conformational change was examined by preincu- bation of 1 µM receptor with 2 µM antagonists ICI 118551... ., 1995). The agonist- or antagonist- bound ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
55 Purinergic signalling in the nervous system: an overview
 

Summary:  adenosine receptors A1, A2A, A2B and A3 are G- protein coupled (Figure 1). Typically, A1 and A3 couple... to the Gi/o family of G proteins inhibiting cyclic AMP (cAMP) production, whereas A2A and A2B stimulate c... , ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
56 Pharmacology of ionotropic glutamate receptors: A structural perspective Philipp Stawski, Harald Janovjak, Dirk Trauner
 

Summary:  receptors AMPA receptors Kainate receptors NMDA receptors Neurotransmitter Clamshell Agonist Antagonist... (agonists, antagonists and modulators) for iono- tropic glutamate receptors is reviewed. Ó 2010 Published... . . . . . . . . . . . . . . . ...

  

Source: Trauner, Dirk - Department Chemie, Ludwig Maximilians Universität München

 

Collection: Chemistry

 
57 Conserved waters mediate structural and functional activation of family A (rhodopsin-like)
 

Summary:  .6 ångstro¨ m crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322... , engineered A2A-adenosine, 1- and 2-adrenergic receptors, permits comparative analysis of features ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
58 Perspectives in Pharmacology In Vivo Gene Modification Elucidates Subtype-Specific
 

Summary:  -adrenergic receptor expression. Mice with a deletion of the 2A- ( 2A-knockout [KO]), 2B- ( 2B-KO), or 2C... , moxonidine was 2-fold less po- tent in 2A-D79N mice. Both the 2-adrenergic receptor-se- lective antagonist SK... treated acutely with the 2-adrenergic ...

  

Source: Kable, Joe - Center for Cognitive Neuroscience & Department of Psychology, University of Pennsylvania

 

Collection: Biology and Medicine

 
59 The potent pharmacological effects of opiates have been recognized by humans since ancient times. Today,
 

Summary:  in the infant rat. In contrast to data obtained in adults, NMDA receptor antagonists are neither effective... differ. Of particular interest is the recent finding that the NMDA receptor antagonist MK801... indicate that NMDA receptor antagonists are not effective in ...

  

Source: Barr, Gordon A. - Department of Psychology, Hunter College, City University of New York

 

Collection: Biology and Medicine

 
60 Neuropharmacology 40 (2001) 749760 www.elsevier.com/locate/neuropharm
 

Summary:  antagonist against NMDA-induced currents in Xenopus oocytes expressing NR1-1a/2A or NR1-1a/2B receptors... acamprosate acts as a weak NMDA- receptor antagonist, but modulates NMDA-receptor subunit expression similar... - ...

  

Source: Durstewitz, Daniel - Research Group Computational Neuroscience, Central Institute of Mental Health,

 

Collection: Computer Technologies and Information Sciences ; Biology and Medicine


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61 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS Predicted structures of agonist and
 

Summary:  that the predicted binding energies of eight antagonists to the predicted structure of A2A were found to correlate... Alignments of the four adenosine receptor (AR) subtypes, A1, A2A, A2B, and A3 from the PredicTM method... ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
62 Functional Contribution of a3L80 Neuronal Nicotinic a3 Receptor
 

Summary:  receptors. Similarly, significant changes in antagonist potency were produced by the Ala and Ser... antagonist; two-electrode voltage clamp The muscle and neuronal nicotinic acetylcholine receptor (n... described, a2­ a10 and b2­b4 (Hogg et ...

  

Source: Lasalde Dominicc, Jose A. - Department of Biology, Universidad de Puerto Rico - Rio Piedras

 

Collection: Biology and Medicine

 
63 GPCR agonist binding revealed by modeling and crystallography
 

Summary:  structure of a human A2A adenosine receptor bound to an antagonist. Science 322, 1211­1217 10 Wu, B. et al... . et al. (2010) Structure-based discovery of novel chemotypes for adenosine A(2A) receptor ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
64 Desensitized nicotinic receptors in brain Hai Wanga,*, Xiulan Sunb
 

Summary:  subtypes because they contain no g, y or e subunits, and consist of various complements of a2­a10 and h2­h4... subunits [153]. Additionally, a2­a10 and h2­h4 subunits have been identified and cloned from human brain... be prevented by a´-bungarotoxin or MLA, ...

  

Source: Cooper, Robin L. - Department of Biology, University of Kentucky

 

Collection: Environmental Sciences and Ecology ; Biology and Medicine

 
65 proteinsSTRUCTURE O FUNCTION O BIOINFORMATICS GPCR 3D homology models for ligand
 

Summary:  learned from blind predictions of adenosine A2a receptor complex Vsevolod Katritch,1 Manuel Rueda,2 Polo... - mined high resolution structures of b-adrenergic (b2AR,6,7 b1AR8) and adenosine A2a receptors... Abbreviations: ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
66 Norepinephrine Modulates Glutamatergic Transmission in the Bed Nucleus of the Stria Terminalis
 

Summary:  . In addition, this increase is also reduced by the a2-AR antagonist yohimbine and is absent in the a2A... -adrenergic receptor (b-AR) antagonists or a2-adrenergic receptor (a2-AR) agonists can inhibit footshock... transmission in both dBNST and ...

  

Source: Blakely, Randy - Department of Pharmacology, Vanderbilt University

 

Collection: Biology and Medicine

 
67 The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1
 

Summary:  )2 receptor antagonist, D-AP5, has neuroprotective and anticonvulsant proper- ties (reviewed by Choi... an antagonist molecule dissociated from the receptor. The authors proposed a model whereby the dissociation... The Glutamate Receptor Ion Channels RAYMOND DINGLEDINE,1 KARIN BORGES, ...

  

Source: Traynelis, Stephen F. - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
68 ASSOCIATE EDITOR: DIANNE M. PEREZ The Significance of G Protein-Coupled Receptor
 

Summary:  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 925 4. A2a-adenosine receptor structure... (Warne et al., 2008, 2011), A2a-adenosine (Jaakola et al., 2008; Xu et al., 2011), chemokine C... ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
69 Cellular/Molecular Glutamate Spillover in the Striatum Depresses Dopaminergic
 

Summary:  ). Similarly, neither the adenosine A1 receptor antagonist DPCPX (1 M) nor the A2a receptor antagonist ZM241385... ) nor the A2a receptor ...

  

Source: Sulzer, David - Departments of Neurology & Psychiatry, Columbia University

 

Collection: Biology and Medicine

 
70 Development/Plasticity/Repair Spinal Adenosine A2a Receptor Activation Elicits Long-
 

Summary:  rats, MSX-3 (130 ng kg 1 ; 10 M dissolved in DMSO; Sigma-Aldrich), a specific A2a receptor antagonist... caused by C4 spinal A2a a receptor activation. The dose of ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine

 
71 Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1401-1405, February 1996
 

Summary:  -cell receptor antagonists. Results of recent experiments with altered peptide ligands compare favorably with T... with complete T-cell receptor phos- phorylation and activation of the tyrosine kinase ZAP-70, whereas antagonist... on this idea by proposing that incomplete receptor ...

  

Source: Rabinowitz, Joshua D. - Lewis-Sigler Institute for Integrative Genomics & Department of Molecular Biology, Princeton University

 

Collection: Biology and Medicine ; Biotechnology

 
72 Binding, gating, anity and ecacy The nature of the problem
 

Summary:  -Katz mechanism Two states and constitutve activity Haemoglobin as a receptor What does `allosteric' mean? What... antagonists? Two more direct approaches to the binding site The substituted cysteine accessibility method... nicotinic acetylcholine receptor Eect of dierent agonists ont he frog endplate ...

  

Source: Colquhoun, David - Department of Pharmacology, University College London

 

Collection: Biology and Medicine

 
73 Engineering G protein-coupled receptor expression in bacteria
 

Summary:  -evolving stability and conformational homogeneity of the human adenosine A2a receptor. Proc Natl Acad Sci USA 105... Engineering G protein-coupled receptor expression in bacteria Georgios Skretas* and George Georgiou... receptors called G protein- coupled ...

  

Source: Georgiou, George - Departments of Biomedical Engineering, & Chemical Engineering, University of Texas at Austin

 

Collection: Engineering ; Biotechnology

 
74 Published: February 07, 2011 r 2011 American Chemical Society 420 dx.doi.org/10.1021/ci100375b |J. Chem. Inf. Model. 2011, 51, 420433
 

Summary:  -6 and human A2A adenosine receptors (hAA2AR).7 Inadditionthestructures for turkey1 (t1AR),8 bovine rhodopsin... for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors Soo-Kyung Kim, Youyong Li, Ravinder... ). We examine the dynamics for the ...

  

Source: Goddard III, William A. - Materials and Process Simulation Center & Department of Chemistry, California Institute of Technology

 

Collection: Materials Science

 
75 Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors
 

Summary:  receptors is based mainly on effects of ETA-specific antagonists. The contribution of ETB... the injection. To achieve ET receptor inhibition, saline was replaced by an infusion of an antagonist (7 nmol... using the same protocol, except that the ETB-receptor ...

  

Source: Just, Armin - Physiologisches Institut I, Albert-Ludwigs-Universität Freiburg

 

Collection: Biology and Medicine

 
76 Adenosine triphosphate as a neurotransmitter and neuromodulator Geoffrey Burnstock
 

Summary:  of receptor cloning and selective agonists and antagonists, four subclasses of P1-purinoceptors are recognized... so far, namely A1, A2a, A2b, and A3. The first subclasses for P2-purinoceptors, proposed by Burnstock... , Le Moine C, Fisone G, et al. (1999): Distribution, biochemistry and ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
77 REVIEW ARTICLE The journey to establish purinergic signalling in the gut
 

Summary:  cloned, namely, A1, A2A, A2B, and A3. Seven subtypes of P2X receptors have been identified... and P2Y12 receptors were demonstrated on enteric neurons. Differential gene expression of A1, A2A, A2B... of adenosine A1, ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
78 JOURNAL OF CELLULAR PHYSIOLOGY 200:309317 (2004) Significance of N-Methyl-D-Aspartate (NMDA)
 

Summary:  to MK-801 (NMDA receptor antagonist) and express NR1 mRNA (Morhenn et al., 1994). The BSCs also display... Ca2þ responses and antagonists to the NMDA receptor block them. Moreover, NMDA-evoked Ca2þ responses... and Taichman, 1994). These suprabasal cells are also found to express atypical integrins ...

  

Source: Bear, Mark - Picower Institute for Learning and Memory & Department of Brain and Cognitive Science, Massachusetts Institute of Technology (MIT)

 

Collection: Biology and Medicine

 
79 EDITED B'r' Bertha K. Madras Harvard Medical School
 

Summary:  , and serotonin (5-HT3) receptors. Currently, 12 neu- ronal nAChR subunits have been identified (a2--a1 0 and 132... receptors as a7 because long-term potentiation was blocked by methyllycaconitine, an a7-specific antagonist... Francisco #12;Neuronal Nicotinic ...

  

Source: Lester, Henry - Division of Biology, California Institute of Technology

 

Collection: Biology and Medicine

 
80 Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking
 

Summary:  Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking Matthieu... hormone receptor (TR) ligand-binding domain in its predicted antagonist-bound conformation and used... by transfection and receptor binding experiments. The extreme structural diversity of the ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine


Page:   1  2  3  4  5 
Page:   1  2  3  4  5 
 
81 Summary and conclusions Summary and conclusions
 

Summary:  as the development of specific receptor antagonists with serotonin reuptake inhibition (nefazodone, trazodone). More... antagonist SB242084. We hypothesised that there may be 5-HT2C receptors on GABA neurons located in terminal... recently there have been studies into neuropeptides and targets located ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
82 Role of delivery and trafficking of d-opioid peptide receptors in opioid
 

Summary:  and simultaneously attenuate DOP receptor activity by either blocking surface DOP receptors with antagonists... Role of delivery and trafficking of d-opioid peptide receptors in opioid analgesia and tolerance Xu... for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Changes in the ...

  

Source: Tian, Weidong - Institute of Biochemistry and Cell Biology, Shanghai Institute of Biological Sciences

 

Collection: Biology and Medicine

 
83 ARTICLE doi:10.1038/nature10236 Structure of the human histamine H1
 

Summary:  for adenosine A2A receptor antagonists. J. Med. Chem. 53, 1799­1809 (2010). 26. Rosenbaum, D. M. et al. GPCR... ­491 (2008). 20. Jaakola, V. P. et al. The 2.6 angstrom crystal structure of a human A2A adenosine ...

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collection: Biology and Medicine

 
84 oo26-895x196/o3o54o-o7$3.oo/o Copyright by The American Society for Pharmacology and Experimental Therapeutics
 

Summary:  with a Kb of 6 p.M while inhibiting AMPA receptors with a Kb of >100 p.M. The remaining antagonists showed... competitive antagonists block native AMPA and kainate receptors with approximately similar potencies, which... receptor subtypes is based largely on studies involving ...

  

Source: Huettner, James E. - Department of Cell Biology and Physiology, Washington University in St. Louis

 

Collection: Biology and Medicine

 
85 Review Article Purinergic receptor-mediated effects of adenosine 5 -triphosphate
 

Summary:  protein-coupled P1 receptor subtypes have been cloned: A1, A2A, A2B and A3.19 P2 receptors are subdivided... purinergic receptor agonists and antagonists. There are a growing number of selective antagonists to help... ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
86 Purines and Sensory Nerves Geoffrey Burnstock
 

Summary:  levels in the endo- lymph has been demonstrated during sound exposure. The P2 receptor antagonist PPADS... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 380 Abstract P2X and P2Y nucleotide receptors are described on sensory neurons and their ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
87 Subtype-Specific Dimerization of 1-Adrenoceptors: Effects on Receptor Expression and Pharmacological Properties
 

Summary:  Subtype-Specific Dimerization of 1-Adrenoceptors: Effects on Receptor Expression... was examined using coimmunoprecipitation of epitope-tagged receptors. Human 1-adrenoceptor subtypes ( 1A, 1B, 1... of receptors with different tags and was not altered by norepinephrine treatment. Heterodimer forma- tion

  

Source: Hall, Randy A - Department of Pharmacology, Emory University

 

Collection: Biology and Medicine

 
88 RESEARCH PAPER Role of ATP and related purines in inhibitory
 

Summary:  , Table 3). Effects of A1, A2A, A2B and A3 receptor antagonists on relaxations to EFS, adenosine and NECA... ZM241385 (0.1 mM), a selective A2A receptor antagonist, reduced relaxations ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
89 1999 Macmillan Magazines Ltd 7. Carter, C. S. et al. Anterior cingulate cortex, error detection, and the on-line monitoring of
 

Summary:  ±5 ; however, the individual roles of the three highly homologous a2-adrenergic-receptor subtypes (a2A, a2B, a2... the genes encoding the three a2- adrenergic-receptor subtypes were disrupted. Here we show that both the a2A... ...

  

Source: Kobilka, Brian - Department of Molecular and Cellular Physiology, Stanford University

 

Collection: Biology and Medicine

 
90 Kidney International, Vol. 64 (2003), pp. 13891397 Unusual absence of endothelium-dependent or -independent
 

Summary:  - sions followed: P1 receptors into A1, A2A, A2B, and A3 and P2 receptors into P2X and P2Y subtypes based... of antagonists to P2X receptors and 1-adrenoceptors was examined. Concentration- response curves were constructed... stimulation induced ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
91 This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research
 

Summary:  t Caffeine is an antagonist at A1 and A2A adenosine receptors and epidemiological evidence suggests... -inflammatory influence of A2A receptor activation to proinflammatory [8]. Caffeine is an ...

  

Source: Wenk, Gary - Departments of Psychology & Neuroscience, Ohio State University

 

Collection: Biology and Medicine

 
92 Oligomeric forms of G protein-coupled receptors (GPCRs)
 

Summary:  found in crystals of engineered human b2-adrenergic receptor [29] and an engineered human A2A adenosine... ­1265 30 Jaakola, V.P. et al. (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor... Oligomeric ...

  

Source: Palczewski, Krzysztof - Department of Pharmacology, Case Western Reserve University

 

Collection: Biology and Medicine

 
93 Introduction Chapter 1 1 Introduction
 

Summary:  ; however, the receptors were not susceptible to blockade by selective 5-HT2 and 5-HT3 antagonists19... receptor selective antagonist, revealed that this receptor subtype is not likely to act as an autoreceptor... receptor antagonist was unable to ...

  

Source: Groningen, Rijksuniversiteit - Centre for Ecological and Evolutionary Studies, Department of Marine Benthic Ecology and Evolution,

 

Collection: Biology and Medicine ; Environmental Sciences and Ecology

 
94 BioMed Central Page 1 of 12
 

Summary:  -Zahn EM: Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision... with mechanosensory transduction in the organs considered, including P2X3 and P2X2/3 receptor antagonists... responses consisted of both fast and slow components. ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
95 Blockade of the NPY Y5 receptor potentiates circadian responses to light: complementary in vivo and in vitro studies
 

Summary:  an antagonist to NPY receptors can be used to potentiate photic phase shifts late in the subjective night. First... effect was probably mediated by the Y5 receptor, since co-application of Y5 receptor antagonists... completely reversed the effect of NPY, while application of a Y1 ...

  

Source: Harrington, Mary - Department of Psychology, Smith College

 

Collection: Biology and Medicine

 
96 DEPENDENCE ON METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION BUT ENTRY IN THE GENESIS OF NOVEL CONVULSANT-INDUCED
 

Summary:  DEPENDENCE ON METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION BUT NOT CA2+ ENTRY IN THE GENESIS OF NOVEL... transmission, independent of ionotropic receptors, and (2) bursting mediated chemically in the absence... receptor blockers CNQX/APV re-emerged after applying TEA/4AP. Activity block by carbenoxolone implicated

  

Source: Hochman, Shawn - Department of Physiology, Emory University

 

Collection: Biology and Medicine

 
97 Cellular/Molecular Adenosine-Evoked Hyperpolarization of Retinal Ganglion
 

Summary:  was abolished by the A1 antagonist 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) but was unaffected by A2a , A2b... receptors to decrease neurotransmitter release or A2A receptors to potentiate neuro- ...

  

Source: Newman, Eric A. - Department of Neuroscience, University of Minnesota

 

Collection: Biology and Medicine

 
98 The birth and postnatal development of purinergic signalling G. Burnstock,1
 

Summary:  ),Chesselletal.(1997a),Laloetal.(1998), Ralevicetal.(1999),Brown&Dale(2002),Vasiljevetal.(2003) AstrogliaA1,A2A... ;Table1(Continued) TissuePurinoceptorsMainfunctionalroleReferences OligodendrogliaA1,A2A,A2B,A3... .(2001),Matuteetal. (2007) ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
99 Physiology and Pathophysiology of Purinergic Neurotransmission
 

Summary:  receptors Four subtypes of P1 receptors have been cloned, namely, A1, A2A, A2B, and A3 (see Refs. 370, 423... agonists and antagonists are available for the P1 receptor subtypes (817; Table 2). For a specific review... , WRC-0571 Gi/Go2cAMP ...

  

Source: Burnstock, Geoffrey - Autonomic Neuroscience Centre, University College London

 

Collection: Biology and Medicine

 
100 Purinergic receptors modulate MAP kinases and transcription factors that control microglial inflammatory gene expression
 

Summary:  .R., Shanley, T.P., 2002. The A2A receptor mediates an endogen- ous regulatory pathway of cytokine expression... . For example, pretreatment of J774 murine macrophages with oxidized ATP (oATP), a P2X7 receptor antagonist... are also observed in astrocytes where ...

  

Source: Kalil, Ronald E. - Neuroscience Training Program & W.M. Keck Laboratory for Biological Imaging, University of Wisconsin at Madison

 

Collection: Biology and Medicine


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